ovariectomized

By Targets:	Angiotensin-converting Enzyme (ACE) (1) Apoptosis (3) Autophagy (1) Bcl-2 Family (1) Caspase (1) Cytochrome P450 (2) Epigenetic Reader Domain (1) ERK (1) Estrogen Receptor/ERR (3) HDAC (1) Monoamine Oxidase (2) NF-κB (1) p38 MAPK (1) PARP (1) PKA (1) RAR/RXR (2) Reactive Oxygen Species (1)
By Research Areas:	Cancer (6) Endocrinology (1) Inflammation/Immunology (4) Metabolic Disease (5)
Click Chemistry:	Alkynes (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-121149

Droloxifene 1 Publications Verification 3-Hydroxytamoxifen	Estrogen Receptor/ERR Apoptosis	Cancer
Droloxifene, a Tamoxifen derivative, is an orally active and selective estrogen receptor modulator. Droloxifene shows antiestrogenic and anti-implantation effects. Droloxifene induces p53 expression and apoptosis in MCF-7 cells. Droloxifene prevents bone loss in ovariectomized rats .

HY-N0260

Epmedin C

2 Publications Verification

Epimedin-C; Baohuoside-VI
Others Inflammation/Immunology

Epmedin C, a natural product, has estrogen-like effects for ovariectomized mice.

Epmedin C 2 Publications Verification Epimedin-C; Baohuoside-VI	Others	Inflammation/Immunology
Epmedin C, a natural product, has estrogen-like effects for ovariectomized mice.

HY-110218

CW 008	PKA Epigenetic Reader Domain	Others
CW 008, a derivative of pyrazole-pyridine, is a CREB or PKA pathway agonist. CW 008 also is a stem cell differentiating agent. CW 008 stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion .

HY-119395B

Kynuramine dihydrochloride

Monoamine Oxidase Metabolic Disease

Kynuramine, an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase .
HY-121528

Nilestriol

Nylestriol; EE3CPE
Estrogen Receptor/ERR Endocrinology

Nilestriol is a estriol derivative, which inhibits osteoporosis on ovariectomized rats or postmenopausal women .
HY-119395A

Kynuramine dihydrobromide

Monoamine Oxidase Metabolic Disease

Kynuramine dihydrobromide, an endogenously occurring amine, is a fluorescent substrate of plasma amine oxidase .

Kynuramine dihydrochloride	Monoamine Oxidase	Metabolic Disease
Kynuramine, an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase .

Nilestriol Nylestriol; EE3CPE	Estrogen Receptor/ERR	Endocrinology
Nilestriol is a estriol derivative, which inhibits osteoporosis on ovariectomized rats or postmenopausal women .

Kynuramine dihydrobromide	Monoamine Oxidase	Metabolic Disease
Kynuramine dihydrobromide, an endogenously occurring amine, is a fluorescent substrate of plasma amine oxidase .

HY-106019C

Liarozole dihydrochloride R75251 dihydrochloride	Cytochrome P450 RAR/RXR	Metabolic Disease Inflammation/Immunology Cancer
Liarozole (R75251) dihydrochloride is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA). Liarozole dihydrochloride inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of RA (IC₅₀=7 μM), resulting in increased tissue levels of RA. Liarozole dihydrochloride shows antitumoral properties .

HY-106019

Liarozole R75251	Cytochrome P450 RAR/RXR	Metabolic Disease Inflammation/Immunology Cancer
Liarozole (R75251; R85246) is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA). Liarozole inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of retinoic acid (IC₅₀=7 μM), resulting in increased tissue levels of retinoic acid. Liarozole shows antitumoral properties .

HY-W009732

Sinapinic acid 3 Publications Verification Sinapic acid	HDAC Angiotensin-converting Enzyme (ACE) Reactive Oxygen Species Apoptosis	Metabolic Disease Cancer
Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Rhizome, acts as an inhibitor of HDAC, with an IC₅₀ of 2.27 mM , and also inhibits ACE-I activity . Sinapinic acid posssess potent anti-tumor activity, induces apoptosis of tumor cells . Sinapinic acid shows antioxidant and antidiabetic activities . Sinapinic acid reduces total cholesterol, triglyceride, and HOMA-IR index, and also normalizes some serum parameters of antioxidative abilities and oxidative damage in ovariectomized rats .

HY-13738

Raloxifene Maximum Cited Publications 9 Publications Verification Keoxifene; LY156758 free base; LY139481	Estrogen Receptor/ERR	Cancer
Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research .

HY-N0213

Peiminine 3 Publications Verification Verticinone; Raddeanine	Autophagy Caspase Bcl-2 Family PARP p38 MAPK ERK NF-κB Apoptosis	Inflammation/Immunology Cancer
Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0260

Epmedin C 2 Publications Verification Epimedin-C; Baohuoside-VI	Flavonols Flavonoids Monophenols Classification of Application Fields Source classification Phenols Epimedium brevicornu Maxim. Plants Berberidaceae Disease Research Fields Inflammation/Immunology	Others
Epmedin C, a natural product, has estrogen-like effects for ovariectomized mice.

HY-W009732

Sinapinic acid 3 Publications Verification Sinapic acid	Monophenols other families Classification of Application Fields Simple Phenylpropanols Source classification Phenols Metabolic Disease Phenylpropanoids Plants Disease Research Fields	HDAC Angiotensin-converting Enzyme (ACE) Reactive Oxygen Species Apoptosis
Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Rhizome, acts as an inhibitor of HDAC, with an IC₅₀ of 2.27 mM , and also inhibits ACE-I activity . Sinapinic acid posssess potent anti-tumor activity, induces apoptosis of tumor cells . Sinapinic acid shows antioxidant and antidiabetic activities . Sinapinic acid reduces total cholesterol, triglyceride, and HOMA-IR index, and also normalizes some serum parameters of antioxidative abilities and oxidative damage in ovariectomized rats .

HY-N0213

Peiminine 3 Publications Verification Verticinone; Raddeanine	Alkaloids Piperidine Alkaloids Structural Classification Liliaceae Fritillaria thunbergii Miq. Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Autophagy Caspase Bcl-2 Family PARP p38 MAPK ERK NF-κB Apoptosis
Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models .

Cat. No.	Product Name		Classification

HY-121528

Nilestriol

Nylestriol; EE3CPE
Alkynes

Nilestriol is a estriol derivative, which inhibits osteoporosis on ovariectomized rats or postmenopausal women .

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