Search Result

Results for "

oxidase

" in MCE Product Catalog:

By Targets:	Monoamine Oxidase (128) NADPH Oxidase (16) Xanthine Oxidase (37) 5-HT Receptor (2) Acyltransferase (1) Adenosine Receptor (2) Adrenergic Receptor (6) Akt (3) AMPK (1) Amyloid-β (2) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (3) Apoptosis (15) Aryl Hydrocarbon Receptor (1) Autophagy (4) Bacterial (16) Biochemical Assay Reagents (2) c-Met/HGFR (4) Cholinesterase (ChE) (7) COMT (2) COX (1) Cytochrome P450 (1) DNA Stain (1) DNA/RNA Synthesis (1) Dopamine Transporter (1) Dopamine β-hydroxylase (1) Drug Metabolite (8) EGFR (1) Endogenous Metabolite (33) Estrogen Receptor/ERR (1) Ferroptosis (3) Fluorescent Dye (3) Formyl Peptide Receptor (FPR) (5) Guanylate Cyclase (3) HBV (1) HDAC (1) Histamine Receptor (1) Histone Demethylase (9) HIV (2) HSV (1) iGluR (1) Imidazoline Receptor (3) Influenza Virus (2) Isotope-Labeled Compounds (2) JAK (1) Liposome (1) Lipoxygenase (1) Microtubule/Tubulin (2) Mitochondrial Metabolism (1) NF-κB (1) NO Synthase (5) Nucleoside Antimetabolite/Analog (7) Parasite (5) PARP (1) Phosphatase (1) Phosphodiesterase (PDE) (2) PI3K (2) PKC (1) Reactive Oxygen Species (12) Reverse Transcriptase (1) Small Interfering RNA (siRNA) (2) Sodium Channel (1) TGF-beta/Smad (1) TNF Receptor (1) Toll-like Receptor (TLR) (3) TRP Channel (1) Tyrosinase (1)
By Research Areas:	Cancer (64) Cardiovascular Disease (23) Endocrinology (7) Infection (34) Inflammation/Immunology (56) Metabolic Disease (56) Neurological Disease (100)

By Targets:

Monoamine Oxidase (128)

NADPH Oxidase (16)

Xanthine Oxidase (37)

5-HT Receptor (2)

Acyltransferase (1)

Adenosine Receptor (2)

Adrenergic Receptor (6)

Akt (3)

AMPK (1)

Amyloid-β (2)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (3)

Apoptosis (15)

Aryl Hydrocarbon Receptor (1)

Autophagy (4)

Bacterial (16)

Biochemical Assay Reagents (2)

c-Met/HGFR (4)

Cholinesterase (ChE) (7)

COMT (2)

COX (1)

Cytochrome P450 (1)

DNA Stain (1)

DNA/RNA Synthesis (1)

Dopamine Transporter (1)

Dopamine β-hydroxylase (1)

Drug Metabolite (8)

EGFR (1)

Endogenous Metabolite (33)

Estrogen Receptor/ERR (1)

Ferroptosis (3)

Fluorescent Dye (3)

Formyl Peptide Receptor (FPR) (5)

Guanylate Cyclase (3)

HBV (1)

HDAC (1)

Histamine Receptor (1)

Histone Demethylase (9)

HIV (2)

HSV (1)

iGluR (1)

Imidazoline Receptor (3)

Influenza Virus (2)

Isotope-Labeled Compounds (2)

JAK (1)

Liposome (1)

Lipoxygenase (1)

Microtubule/Tubulin (2)

Mitochondrial Metabolism (1)

NF-κB (1)

NO Synthase (5)

Nucleoside Antimetabolite/Analog (7)

Parasite (5)

PARP (1)

Phosphatase (1)

Phosphodiesterase (PDE) (2)

PI3K (2)

PKC (1)

Reactive Oxygen Species (12)

Reverse Transcriptase (1)

Small Interfering RNA (siRNA) (2)

Sodium Channel (1)

TGF-beta/Smad (1)

TNF Receptor (1)

Toll-like Receptor (TLR) (3)

TRP Channel (1)

Tyrosinase (1)

By Research Areas:

Cancer (64)

Cardiovascular Disease (23)

Endocrinology (7)

Infection (34)

Inflammation/Immunology (56)

Metabolic Disease (56)

Neurological Disease (100)

306

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Xanthine Oxidase NADPH Oxidase Monoamine Oxidase

Cat. No.	Product Name	Target	Research Areas

HY-W176012

*Glycolate oxidase-IN-1*	Others	Metabolic Disease
Glycolate oxidase-IN-1(compound 26), a salicylic acid derivative, is a glycolate oxidase (GO) inhibitor with an IC₅₀ of 38.2 μM. Glycolate oxidase-IN-1 has the ability to reduce oxalate production in hyperoxalate hepatocytes and can be used in the study of primary hyperoxaluria type 1 (PH1).

HY-N10432

Xanthine oxidase-IN-8
Icarisids J
Xanthine Oxidase Metabolic Disease

Xanthine oxidase-IN-8 (Icarisids J) (Compound 7) is a XOD inhibitor with an IC₅₀ of 29.71 μM.

*Xanthine oxidase-IN-8* Icarisids J	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-8 (Icarisids J) (Compound 7) is a XOD inhibitor with an IC₅₀ of 29.71 μM.

HY-P2742

Ascorbate oxidase ASO	Endogenous Metabolite	Metabolic Disease
Ascorbate oxidase, also known as vitamin C oxidase, is a REDOX enzyme involved in the regulation of extracellular matrix. Ascorbate oxidase catalyzes the reaction of ascorbic acid and oxygen to produce dehydroascorbic acid.

HY-P2891

Pyruvate oxidase PoxB	Endogenous Metabolite	Others
Pyruvate oxidase (PoxB) is a thiamine pyrophosphate-dependent oxidase that catalyzes the oxidative decarboxylation of pyruvate to acetyl phosphate, carbon dioxide and water. Pyruvate oxidase is an important enzyme in bacterial metabolism and is often used in biochemical research.

HY-P2888

Bilirubin oxidase BOD	Endogenous Metabolite	Metabolic Disease
Bilirubin oxidase (BOD) is a multi-copper oxidase that catalyzes the oxidation of bilirubin to biliverdin and reduces molecular oxygen to water. Bilirubin oxidase can participate in the metabolism of porphyrin and chlorophyll, and is widely used in biochemical research as a catalyst for oxygen reduction.

HY-P2743

Choline oxidase	Biochemical Assay Reagents	Others
Choline oxidase catalyzes the oxidation of choline to glycine betaine via betaine aldehyde in glycine betaine biosynthesis and betaine acts as an osmolyte. Choline oxidase has potential in enzymatic betaine production.

HY-146273

*Xanthine oxidase-IN-7*	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-7 (compound1h) is a potent andorally active XO (xanthine oxidase) inhibitor with an IC₅₀ of 0.36 µM. Xanthine oxidase-IN-7 effectively reduces serum uric acid levels. Xanthine oxidase-IN-7 has the potential for the research of hyperuricemia and gout.

HY-P2910

Galactose oxidase GOase	Endogenous Metabolite	Others
Galactose oxidase (GOase) from fungus is often used in biochemical studies. Galactose oxidase is a type II copper metalloenzyme, and it containing a single polypeptide. Galactose oxidase catalyzes two-electron oxidation of primary alcohols to their corresponding aldehydes, coupling with the reduction of dioxygen to hydrogen peroxide.

HY-144303

*Xanthine oxidase-IN-4*	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-4 (compound 19a) is an orally active and potent *xanthine oxidase* (XO) inhibitor, with an IC₅₀** of 0.039 μM. Xanthine oxidase-IN-4 exhibits hypouricemic potency in potassium oxonate induced hyperuricemia rats. Xanthine oxidase-IN-4 can be used for hyperuricemia and gout research.

HY-P2733

Glycerol-3-phosphate oxidase GPO	Endogenous Metabolite	Metabolic Disease
Glycerol-3-phosphate oxidase is a key intermediate in glycerol metabolism. Glycerol-3-phosphate oxidase can be extracted from Escherichia coli. Glycerol-3-phosphate oxidase is the skeleton of phospholipids in membrane lipids, and also the substrate of respiratory chain. Glycerol-3-phosphate oxidase produces electrons through oxidation.

HY-P2921

Urate oxidase Uox	Endogenous Metabolite	Others
Urate oxidase (Uox), i.e., uricase, is often used in biochemical studies. Urate oxidase is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most mammals.

HY-P2986

D-Amino acid oxidase	Endogenous Metabolite	Metabolic Disease
D-Amino acid oxidase is an enzyme to metabolize exogenous D-amino acids in animals for detoxifying action. D-Amino acid oxidase also modulates the level of D-serine in brain.

HY-146560

*Xanthine oxidase-IN-6*	Xanthine Oxidase NF-κB Toll-like Receptor (TLR) TNF Receptor	Metabolic Disease Inflammation/Immunology
Xanthine oxidase-IN-6 (Compound 6c) is a potent, orally active, mixed-type xanthine oxidase (XOD) inhibitor with an IC₅₀ value of 1.37 µM. Xanthine oxidase-IN-6 shows strong anti-hyperuricemia and renal protective activity.

HY-144456

*Xanthine oxidase-IN-5*	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-5 is an effective and orally active xanthine oxidase (XO) inhibitor with IC₅₀ value of 0.70 μM. Xanthine oxidase-IN-5 displays favorable agent-like properties with ligand efficiency (LE) and lipophilic ligand efficiency (LLE) values of 0.33 and 3.41, respectively. Xanthine oxidase-IN-5 shows potent hypouricemic effects in hyperuricemic rat model.

HY-P2848

Cholesterol oxidase ChOx	Endogenous Metabolite	Others
Cholesterol oxidase (ChOx) is a bacterial flavin oxidase containing FAD, commonly used in biochemical research. Cholesterol oxidase catalyzes the oxidation of the C(3)-OH group of cholesterol (and other sterols) to cholest-5-en-3-one and isomerizes it to cholest-4-en-3-one.

HY-P2987

L-Amino acid oxidase	Endogenous Metabolite	Metabolic Disease
L-Amino acid oxidase is a homodimeric proteins containing flavin adenine dinucleotide. L-Amino acid oxidase can catalyze the stereospecific oxidative deamination of L-amino acids to α-keto acids and ammonia.

HY-151549

*Mtb-cyt-bd oxidase-IN-2*	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-2 is an inhibitor of Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) with an IC₅₀ value of 0.67 μM. Mtb-cyt-bd oxidase-IN-2 inhibits the growth of Mycobacterium tuberculosis with a MIC value of 256 μM. Mtb-cyt-bd oxidase-IN-2 can be used for the research of infection.

HY-E70074

Monoamine oxidase	Monoamine Oxidase	Neurological Disease
Monoamine oxidase is an enzyme composed of different polypeptides. Monoamine oxidation catalyzes the oxidative deamination of various biological amines in brain and peripheral tissues by producing hydrogen peroxide. Monoamine oxidase plays an important role in maintaining the regulation of synaptic transmission, emotional behavior and other brain functions.

HY-152026

*NADPH oxidase-IN-1*	NADPH Oxidase	Neurological Disease
NADPH oxidase-IN-1 is an orally active NADPH oxidase (Nox) inhibitor, related with neuronal inflammation. NADPH oxidase-IN-1 can cross the blood-brain barrier (BBB), inhibits Nox2 and Nox4 with IC₅₀s of 1.9 μM and 2.47 μM, respectively. NADPH oxidase-IN-1 suppresses pro-inflammatory cytokines production and LPS-mediated microglial migration, also has in vivo efficacy.

HY-151548

*Mtb-cyt-bd oxidase-IN-1*	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-1 (compound 1x) is a Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) inhibitor with an IC₅₀ value of 0.13 μM. Mtb-cyt-bd oxidase-IN-1 can be used in tuberculosis research.

HY-151553

*Mtb-cyt-bd oxidase-IN-6*	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-6 is a potent Mycobacterium tuberculosis (Mtb) cytochrome bd (cyt-bd) oxidase (MtbCyt-bd Oxidase) inhibitor with an IC₅₀ value of 0.35 μM. Mtb-cyt-bd oxidase-IN-6 can effectively inhibit the growth of Mtb (MIC= 4 μM). Mtb-cyt-bd oxidase-IN-6 can be used in the study of tuberculosis.

HY-151550

*Mtb-cyt-bd oxidase-IN-3*	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-3 (compound 1u) is a Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) inhibitor with an IC₅₀ value of 0.36 μM. Mtb-cyt-bd oxidase-IN-3 inhibits the growth of Mycobacterium tuberculosis (MIC=32 μM). Mtb-cyt-bd oxidase-IN-3 can be used in tuberculosis research.

HY-151551

*Mtb-cyt-bd oxidase-IN-4*	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-4 (compound 1g) is a Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) inhibitor with an IC₅₀ value of 0.25 μM. Mtb-cyt-bd oxidase-IN-4 inhibits the growth of Mycobacterium tuberculosis (MIC=8 μM). Mtb-cyt-bd oxidase-IN-4 can be used in tuberculosis research.

HY-151552

*Mtb-cyt-bd oxidase-IN-5*	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-5 (compound 1k) is a Mycobacterium tuberculosis (Mtb) cytochrome bd (cyt-bd) oxidase (MtbCyt-bd Oxidase) inhibitor with an IC₅₀ value of 0.37 μM. Mtb-cyt-bd oxidase-IN-5 can effectively inhibit the growth of Mtb (MIC= 256 μM). Mtb-cyt-bd oxidase-IN-5 can be used in the study of tuberculosis.

HY-22166

Glycolic acid oxidase inhibitor 1
Others Metabolic Disease

Glycolic acid oxidase inhibitor 1 is a glycolate oxidase inhibitor, extracted from patent EP0021228A1, in Table IV.

*Glycolic acid oxidase* inhibitor 1**	Others	Metabolic Disease
Glycolic acid oxidase inhibitor 1 is a glycolate oxidase inhibitor, extracted from patent EP0021228A1, in Table IV.

HY-151956

*Mtb-cyt-bd oxidase-IN-7*	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-7 is a *cytochrome bd terminal oxidase* (Cyt-bd) inhibitor with a K_d** value of 4.17 μM. Mtb-cyt-bd oxidase-IN-7 shows anti-tuberculosis activities.

HY-144824

*Monoamine oxidase/Aromatase-IN-1*	Cytochrome P450 Monoamine Oxidase	Cancer Neurological Disease
Monoamine oxidase/Aromatase-IN-1 (compound 2q) is a highly potent *monoamine oxidase* (MAO) and aromatase dual inhibitor with IC₅₀*s of 39 nM and 31 nM for MAO-B and aromatase, respectively. Monoamine oxidase*/Aromatase-IN-1 can be used for researching neurological disorder and breast cancer.

HY-P2902

Glucose oxidase	Endogenous Metabolite	Cancer
Glucose oxidase is used in the food and beverage industry as a preservative and stabilizer and is commonly derived from the fungus Aspergillus niger. Glucose oxidase can react with intracellular glucose and oxygen (O₂) to produce hydrogen peroxide (H₂O₂) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation.

HY-N10433

*Xanthine oxidase-IN-9* Icarisids E	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-9 (Icarisids E) (Compound 2) is a potent *xanthine oxidase* (XOD) inhibitor with an IC₅₀** of 31.81 μM.

HY-143245

*Monoamine Oxidase* B inhibitor 2**	Monoamine Oxidase	Neurological Disease
Monoamine Oxidase B inhibitor 2 is a potent, reversible, orally active and selective *monoamine oxidase* B (MAO-B) inhibitor with an IC₅₀** of 1.33 nM. Monoamine Oxidase B inhibitor 2 has antioxidant and anti-neuroinflammatory activities. Monoamine Oxidase B inhibitor 2 can across the blood-brain barrier (BBB), and can be used for Parkinson’s disease study.

HY-143244

*Monoamine Oxidase* B inhibitor 1**	Monoamine Oxidase	Neurological Disease
Monoamine Oxidase B inhibitor 1 is a potent, reversible, orally active and selective *monoamine oxidase* B (MAO-B) inhibitor with an IC₅₀** of 0.02 nM. Monoamine Oxidase B inhibitor 1 has antioxidant and anti-neuroinflammatory activities. Monoamine Oxidase B inhibitor 1 can across the blood-brain barrier (BBB), and can be used for Parkinson’s disease study.

HY-P2755

Xanthine oxidase	Reactive Oxygen Species	Endocrinology Inflammation/Immunology
Xanthine oxidase is a xanthine oxidoreductase enzyme that generates reactive oxygen species (ROS), catalyzes the oxidation of hypoxanthine to xanthine, and further catalyzes the oxidation of xanthine to uric acid.

HY-P2756

Alcohol oxidase
AO; AOX
Endogenous Metabolite Metabolic Disease

Alcohol oxidase is a functional enzyme of methanol utilization pathway and can be isolated from yeast peroxisome.

Alcohol oxidase AO; AOX	Endogenous Metabolite	Metabolic Disease
Alcohol oxidase is a functional enzyme of methanol utilization pathway and can be isolated from yeast peroxisome.

HY-125860

Tyrosinase Polyphenol oxidase	Tyrosinase	Metabolic Disease
Tyrosinase (Polyphenol oxidase) is a rate-limiting enzyme that controls the production of melanin and is encoded by TYR gene. Tyrosinase is mainly found in melanosomes synthesized by skin melanocytes.

HY-P2861

Sarcosine oxidase SAO	Endogenous Metabolite	Others
Sarcosine oxidase (SAO) can catalyze the oxidative demethylation of sarcosine to generate glycine, H₂O₂, 5,10-CH₂-tetrahydrofolate, which are often used in biochemical reactions.

HY-U00288

*Xanthine oxidase-IN-1* 4-(3-Cyano-5,6-difluoroindol-1-yl)-2-hydroxybenzoic acid	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-1 is a xanthine oxidase inhibitor extracted from patent WO2008126898A1, page 68, compound example 3, with an IC₅₀ of 6.5 nM.

HY-106506

Desciclovir BW A515U	Others	Infection
Desciclovir is a potent and orally active proagent of the antiherpetic agent Acyclovir (ACV). Desciclovir is converted to acyclovir in vivo by xanthine oxidase.

HY-N7397

Forsythoside F
Arenarioside
Xanthine Oxidase Metabolic Disease

Forsythoside F (Arenarioside) is a xanthine oxidase inhibitor and possesses antihyperuricemic effects in vivo.

Forsythoside F Arenarioside	Xanthine Oxidase	Metabolic Disease
Forsythoside F (Arenarioside) is a xanthine oxidase inhibitor and possesses antihyperuricemic effects in vivo.

HY-W224327

Pheniprazine β-Phenylisopropylhydrazine	Monoamine Oxidase	Neurological Disease
Pheniprazine is a potent and long acting inhibitor of monoamine oxidase. Pheniprazine has the potential for the research of depression.

HY-W224327A

Pheniprazine hydrochloride β-Phenylisopropylhydrazine hydrochloride	Monoamine Oxidase	Neurological Disease
Pheniprazine hydrochloride is a potent and long acting inhibitor of monoamine oxidase. Pheniprazine has the potential for the research of depression.

HY-131267

Febuxostat sec-butoxy acid
Drug Metabolite Others

Febuxostat sec-butoxy acid is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.
HY-131269

Febuxostat impurity 7
Drug Metabolite Others

Febuxostat impurity 7 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.
HY-131273

Febuxostat amide impurity
Drug Metabolite Others

Febuxostat amide impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM
HY-131270

Febuxostat impurity 8
Drug Metabolite Others

Febuxostat impurity 8 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.
HY-131253

Febuxostat isopropyl isomer
Drug Metabolite Others

Febuxostat isopropyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.
HY-131271

Febuxostat impurity 6
Drug Metabolite Others

Febuxostat impurity 6 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

Febuxostat sec-butoxy acid	Drug Metabolite	Others
Febuxostat sec-butoxy acid is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

Febuxostat impurity 7	Drug Metabolite	Others
Febuxostat impurity 7 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

Febuxostat amide impurity	Drug Metabolite	Others
Febuxostat amide impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM

Febuxostat impurity 8	Drug Metabolite	Others
Febuxostat impurity 8 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

Febuxostat isopropyl isomer	Drug Metabolite	Others
Febuxostat isopropyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

Febuxostat impurity 6	Drug Metabolite	Others
Febuxostat impurity 6 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

HY-131272

Febuxostat dicarboxylic acid impurity	Drug Metabolite	Others
Febuxostat dicarboxylic acid impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

HY-131266

Febuxostat n-butyl isomer
Drug Metabolite Others

Febuxostat n-butyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

HY-147365

Acifluorfen-methyl	Others	Others
Acifluorfen-methyl is an inhibitor of the heme and chlorophyll biosynthetic enzyme protoporphyrinogen oxidase (Protox). Acifluorfen-methyl is a photobleaching herbicide.

HY-B1877

Nitrofen
Others Cancer

Nitrofen is a selective contact herbicide. Nitrofen is a retinal dehydrogenase and protoporphyrinogen oxidase inhibitor.

HY-132588

Lumasiran ALN-G01	Small Interfering RNA (siRNA)	Metabolic Disease
Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1).

HY-138625A

LOX-IN-3 dihydrochloride	Monoamine Oxidase	Cancer
LOX-IN-3 dihydrochloride is an orally active *lysyl oxidase* (LOX)** inhibitor. LOX-IN-3 dihydrochloride can be used for fibrosis, cancer and angiogenesis research.

HY-138625

LOX-IN-3
Monoamine Oxidase Cancer

LOX-IN-3 is an orally active lysyl oxidase (LOX) inhibitor. LOX-IN-3 can be used for fibrosis, cancer and angiogenesis research.

HY-138625B

LOX-IN-3 dihydrochloride monohydrate	Monoamine Oxidase	Cancer Cardiovascular Disease
LOX-IN-3 dihydrochloride monohydrate (Compound 33) is an orally active *lysyl oxidase* (LOX)** inhibitor. LOX-IN-3 dihydrochloride monohydrate can be used for fibrosis, cancer and angiogenesis research.

HY-108680

Carbazeran citrate	Phosphodiesterase (PDE)	Metabolic Disease
Carbazeran (citrate), a potent phosphodiesterase inhibitor, is aldehyde oxidase substrate. Carbazeran (citrate) can be used for the research of metabolic disease.

HY-W041301

(±)-Dihydroactinidiolide	Others	Others
(±)-Dihydroactinidiolide, an important aroma compound of black tea and tobacco, has been isolated from several plants. (±)-Dihydroactinidiolide can be formation from β-Carotene by the treatment of polyphenoloxidase, the lipoxygenase, and the xanthine oxidase.

HY-W193398

N-2-Cyclohexylethyl-N-methylamine	Monoamine Oxidase	Cardiovascular Disease
N-2-Cyclohexylethyl-N-methylamine is an amine from A.ridigula Benth for a reduction of monoamine oxidase (MAO) activity.

HY-W015490

1,4-Naphthoquinone	Monoamine Oxidase	Cancer
1,4-Naphthoquinone is a potential pharmacophore for inhibition of both MAO (monoamine oxidase) and DNA topoisomerase activities, this latter associated with antitumor activity.

HY-148159

Safrazine	Monoamine Oxidase	Neurological Disease
Safrazine is an irreversible, non-specific and orally active *monoamine oxidase* (MAO)** inhibitor. Safrazine can be used for the research of depression.

HY-N10741

Ellagic acid 4-O-β-D-xylopyranoside	Xanthine Oxidase Bacterial	Infection
Ellagic acid 4-O-β-D-xylopyranoside is a natural ellagitannin with antimicrobial activity. Ellagic acid 4-O-β-D-xylopyranoside is an xanthine oxidase inhibitor with an ₅₀ of 2.1 μg/mL.

HY-N9608

6-Ketocholestanol 3β-Hydroxy-5α-cholestan-6-one	Others	Others
6-Ketocholestanol is a recoupler for mitochondria, chromatophores and cytochrome oxidase proteoliposomes. 6-Ketocholestanol increases the membrane dipole potential.

HY-151210

MAO-B-IN-17	Monoamine Oxidase	Neurological Disease
MAO-B-IN-17 is a selective *monoamine oxidase* B (MAO-B) inhibitor with the IC₅₀** value of 5.08 μM. MAO-B-IN-17 can be used in Parkinson’s disease research.

HY-W015422

1,5-Isoquinolinediol	PARP	Metabolic Disease
1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC₅₀ of 0.18-0.37 µM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina.

HY-151115

JNJ-1289	Others	Cancer Inflammation/Immunology
JNJ-1289 is a potent, selective, competitive and allosteric *human spermine oxidase* (hSMOX) inhibitor (IC₅₀**: 50 nM). JNJ-1289 can be used in the research of polyamine catabolism, inflammation and cancers.

HY-N9329

Glicoricone	Monoamine Oxidase Estrogen Receptor/ERR	Metabolic Disease
Glicoricone, a phenolic compound, is isolated from a species of licorice. Glicoricone is an inhibitor of *monoamine oxidase* (MAO), with an IC₅₀ of 140 μM. Glicoricone binds to estrogen receptor (ER)** and shows estrogen antagonist activity.

HY-13675

ME-143 NV-143	Endogenous Metabolite	Cancer
ME-143 is a second-generation tumor-specific inhibitor of NADH oxidase. ME-143 inhibits the WNT/β-catenin pathway in colorectal cancer cells. ME-143 has broadly active against cancers in vitro and in vivo.

HY-N9540

Methyl citrate	Monoamine Oxidase	Neurological Disease
Methyl citrate is a Monoamine oxidase B (MAO-B) inhibitor (IC₅₀=0.23 mM). Methyl citrate is isolated from the fruits of Opuntia ficus-indica var. saboten Makino.

HY-P99047

Simtuzumab AB 0024; GS 6624	Monoamine Oxidase	Inflammation/Immunology
Simtuzumab (AB 0024; GS 6624) is a monoclonal antibody directed against Lysyl oxidase like-2 (LOXL2). Simtuzumab can be used for the research of primary sclerosing cholangitis (PSC).

HY-135265

Moclobemide N-Oxide Ro 12-5637	Monoamine Oxidase	Neurological Disease
Moclobemide N-Oxide (Ro 12-5637) is N-oxide metabolite of Moclobemide. Moclobemide N-Oxide retains certain MAO-A (monoamine oxidase) inhibitory activity, but is generally present in low concentrations. Moclobemide N-Oxide can be detected by UV absorption at 240 nm.

HY-19915B

Contezolid acefosamil sodium MRX-4 sodium	Bacterial Antibiotic Monoamine Oxidase	Infection Inflammation/Immunology
Contezolid acefosamil sodium (MRX-4), a new and orally active oxazolidinone, is an antibiotic in study for complicated skin and soft tissue infections (cSSTI) caused by resistant Gram-positive bacteria. Contezolid acefosamil sodium (MRX-4) markedly reduces potential for myelosuppression and monoamine oxidase inhibition (MAOI).

HY-N1162

Tetrahydroamentoflavone Amentoflavanone	Xanthine Oxidase	Infection Inflammation/Immunology
Tetrahydroamentoflavone (Amentoflavanone) is a potent *xanthine oxidase* (XO) inhibitor. Tetrahydroamentoflavone has inhibitory activity for XO with IC₅₀ and K_i** values of 92 nM and 0.982 μM, respectively. Tetrahydroamentoflavone can be used for the research of inflammatory disorders and gout.

HY-17447G

Tranylcypromine SKF 385	Monoamine Oxidase	Endocrinology Cardiovascular Disease
Tranylcypromine (SKF 385) (GMP) is Tranylcypromine (HY-17447) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Tranylcypromine (SKF 385) is a potent *monoamine oxidase* (MAO)** inhibitor.

HY-119176

Oxyfluorfen	Others	Others
Oxyfluorfen is a pre- and post-emergence diphenyl ether herbicide to control annual broad-leaved and grass weeds. Oxyfluorfen is a protoporphyrinogen oxidase inhibitor and inhibits photosynthesis by blocking chlorophyll synthesis.

HY-151208

MAO-B-IN-16	Monoamine Oxidase	Neurological Disease
MAO-B-IN-16 is a selective *monoamine oxidase* B (MAO-B) inhibitor, with an IC₅₀** of 1.55 µM. MAO-B-IN-16 can be used in the study of central nervous disorders, such as parkinson's disease.

HY-B1558A

Bifemelane hydrochloride MCI-2016	Monoamine Oxidase	Neurological Disease
Bifemelane hydrochloride (MCI-2016) is a potent, selective and competitive inhibitor of *monoamine oxidase* A (MAO-A), with a K_i of 4.20 μM. Bifemelane hydrochloride also inhibits MAO-B noncompetitively with a K_i** of 46.0 μM. Bifemelane hydrochloride has a potent antidepressant activity and can be used for the research of cognitive and emotional disturbances related to cerebrovascular disease.

HY-132613

Lumasiran sodium	Small Interfering RNA (siRNA)	Metabolic Disease
Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) .

HY-129137

Cyanidin 3-sophoroside chloride Cy 3-soph	Others	Others
Cyanidin 3-sophoroside chloride is a potent non-competitive reversible polyphenol oxidase (PPO) inhibitor. Also, Cyanidin 3-sophoroside chloride can be used as an anti-browning agent to inhibit the degree of PPO browning, enhance the antioxidant damage capacity of fruits and prolong the storage period.

HY-112726

PXS-4728A BI-1467335	Monoamine Oxidase	Inflammation/Immunology
PXS-4728A (BI-1467335) is a selective, orally active inhibitor of semicarbazide-sensitive amine oxidase (SSAO). PXS-4728A ameliorates chronic obstructive pulmonary disease in mice.

HY-N0327

Lobetyolin	Apoptosis Xanthine Oxidase	Metabolic Disease
Lobetyolin, a bioactive compound, is derived from Codonopsis pilosula. Lobetyolin has anti-inflammatory, anti-oxidative and xanthine oxidase inhibiting activities. Lobetyolin also induces the apoptosis via the inhibition of ASCT2-mediated glutamine metabolism.

HY-B0534

Moclobemide Ro111163	Monoamine Oxidase	Neurological Disease
Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC₅₀ of 6.061 μM for hMAO-A.Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

HY-Y1750A

β-Aminopropionitrile hydrochloride BAPN hydrochloride	Monoamine Oxidase Endogenous Metabolite	Cancer Metabolic Disease
β-Aminopropionitrile (BAPN) hydrochloride is a specific, irreversible and orally active *lysyl oxidase* (LOX)** inhibitor. β-Aminopropionitrile hydrochloride targets the active site of LOX or LOXL isoenzymes.

HY-Y1750

β-Aminopropionitrile BAPN	Monoamine Oxidase Endogenous Metabolite	Cancer Metabolic Disease
β-Aminopropionitrile (BAPN) is a specific, irreversible and orally active *lysyl oxidase* (LOX)** inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes.

HY-W014502

D-Kynurenine	Aryl Hydrocarbon Receptor Endogenous Metabolite	Cancer
D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR).

HY-10399

Ladostigil TV-3326	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
Ladostigil (TV-3326) is an orally active dual inhibitor of cholinesterase and brain-selective *monoamine oxidase* (MAO), with IC₅₀s of 37.1 and 31.8 μM for MAO-B and AChE**, respectively. Ladostigil exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease.

HY-10399A

Ladostigil hydrochloride TV-3326 hydrochloride	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
Ladostigil (TV-3326) hydrochloride is an orally active dual inhibitor of cholinesterase and brain-selective *monoamine oxidase* (MAO), with IC₅₀s of 37.1 and 31.8 μM for MAO-B and AChE**, respectively. Ladostigil hydrochloride exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease.

HY-113056A

N1-Acetylspermidine hydrochloride	Endogenous Metabolite	Cancer
N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA.

HY-N1636

1-Methyl-2-nonyl-4(1H)-quinolone	Monoamine Oxidase	Neurological Disease
1-Methyl-2-nonyl-4(1H)-quinolone, a quinolone alkaloid, is a potent and selective MAO-B (monoamine oxidase) inhibitor. 1-Methyl-2-nonyl-4(1H)-quinolone exhibites inhibitory activity on leukotriene biosynthesis, with an IC₅₀ of 12.1 μM.

HY-144075

JAK-IN-19	JAK	Inflammation/Immunology
JAK-IN-19 is a potent JAK inhibitor (PBMC IFNγ pIC₅₀=7.2 and HLF Eotaxin pIC₅₀=7.7). JAK-IN-19 has good retentive properties in the lung via mitigating being metabolized by Aldehyde Oxidase (AO), with diminished VEGFR2 selectivity (VEGFR2 pIC₅₀=7.0, Aurora B pIC₅₀=5.8).

HY-152696

6-O-Methylinosine	Nucleoside Antimetabolite/Analog	Others
6-O-Methylinosine is a hypoxanthine analogue. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.

HY-W018555

D-Cysteine	Endogenous Metabolite Bacterial	Infection Neurological Disease
D-Cysteine is the D-isomer of cysteine and a powerful inhibitor of *Escherichia coli* growth. D-cysteine is mediated by D-amino acid oxidase to produce H₂S and is a neuroprotectant against cerebellar ataxias. D-Cysteine could inhibit the growth and cariogenic virulence of dual-species biofilms formed by *S. mutans* and *S. sanguinis*.

HY-19333

OG-L002	Histone Demethylase Monoamine Oxidase HSV	Infection
OG-L002 is a potent and highly selective LSD1 inhibitor with an IC₅₀ of 0.02 μM. OG-L002 is a potent *monoamine oxidases* (MAO) inhibitor with IC₅₀s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 potently inhibits the expression of HSV IE** genes.

HY-120419

PF9601N	Monoamine Oxidase	Neurological Disease
PF9601N, an *monoamine oxidase* B (MAO-B**) inhibitor, possesses neuroprotective properties in several in vitro and in vivo models of Parkinson's disease (PD). PF9601N can be used for the research of neurodegenerative diseases mediated by excitotoxicity.

HY-W039271

2-Chloro-6-methoxypurine riboside 2-Chloro-6-O-methyl-inosine	Nucleoside Antimetabolite/Analog	Cancer
2-Chloro-6-methoxypurine riboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.

HY-B0840

Chlorfenapyr	Parasite	Metabolic Disease
Chlorfenapyr is a pyrrole insecticide. Chlorfenapyr has a mode of action: the mixed function oxidase oxidizes and removes the Nethoxymethyl group to form the active metabolite, CL 303268. Chlorfenapyr is used for termite control and crop protection against a variety of insect and mite pests.

HY-154393

2-Chloro-2'-deoxy-6-O-methylinosine	Nucleoside Antimetabolite/Analog	Cancer
2-Chloro-2'-deoxy-6-O-methylinosine is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.

HY-154017

2′-C-Methyl-6-O-methylinosine	Nucleoside Antimetabolite/Analog	Cancer
2′-C-Methyl-6-O-methylinosine is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.

HY-103164

(E)-8-(3-Chlorostyryl)caffeine	Adenosine Receptor Monoamine Oxidase	Neurological Disease
(E)-8-(3-Chlorostyryl)caffeine is a selective adenosine A_2A receptor antagonist. (E)-8-(3-Chlorostyryl)caffeine inhibits *monoamine oxidase* B (MAO-B) with a K_i** value of 70 nM by a pathway that is independent of its actions on the A_2A receptor. (E)-8-(3-Chlorostyryl)caffeine has the potential for Parkinson's disease research.

HY-101499A

GKT136901 hydrochloride	NADPH Oxidase	Metabolic Disease Neurological Disease
GKT136901 hydrochloride is a potent, selective and orally active inhibitor of *NADPH oxidase* (NOX1/4), with K_i**s of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity.

HY-101499

GKT136901	NADPH Oxidase	Metabolic Disease Inflammation/Immunology Neurological Disease
GKT136901 is a potent, selective and orally active inhibitor of *NADPH oxidase* (NOX1/4), with K_i**s of 160 and 165 nM, respectively. GKT136901 is also a selective and direct scavenger of peroxynitrite. GKT136901 can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 also has anti-inflammatory activity.

HY-W392836

2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite	Nucleoside Antimetabolite/Analog	Cancer
2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.

HY-152678

6-Methoxypurine-9-β-D-5’(R)-C-methylriboside	Nucleoside Antimetabolite/Analog	Cancer
6-Methoxypurine-9-β-D-5’(R)-C-methylriboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.

HY-W127499

1,2-Dierucoyl-sn-glycero-3-phosphocholine DEPC; L-Dierucoyl lecithin; Dierucoyllecithin	Liposome	Others
1,2-Dierucoyl-sn-glycero-3-phosphocholine (DEPC) is the composition of liposome membrane. 1,2-Dierucoyl-sn-glycero-3-phosphocholine is used for the preparation of liposomes and studying the properties of lipid bilayers. The GO (glucose oxidase) in the 1,2-Dierucoyl-sn-glycero-3-phosphocholine liposome shows the high activity.

HY-B0203B

(Rac)-Nebivolol (Rac)-R 065824	Adrenergic Receptor NADPH Oxidase	Cardiovascular Disease
(Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC₅₀ value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity.

HY-W141392

2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite	Nucleoside Antimetabolite/Analog	Cancer
2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.

HY-W008566

Norharmane Norharman; β-Carboline	Monoamine Oxidase Endogenous Metabolite	Cancer Infection Neurological Disease
Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC₅₀ values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings.

HY-33009

AS057278	Others	Neurological Disease
AS057278 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant non-peptidic *D-amino acid oxidase* (DAAO) inhibitor with an IC₅₀ value of 0.91 μM and EC₅₀** of 2.2-3.95 μM. AS057278 can normalize phencyclidine (PCP)-induced prepulse inhibition in mice. AS057278 can be used for researching schizophrenia.

HY-119395A

Kynuramine dihydrobromide
Monoamine Oxidase Metabolic Disease

Kynuramine dihydrobromide, an endogenously occurring amine, is a fluorescent substrate of plasma amine oxidase.
HY-119395B

Kynuramine dihydrochloride
Monoamine Oxidase Metabolic Disease

Kynuramine, an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase.
HY-114507

Flumioxazin
Sumisoya; V-53482
Others Others

Flumioxazin (Sumisoya) is an herbicide for use in soybean and peanut. Flumioxazin inhibits the enzyme protoporphyrinogen oxidase.

HY-14202

Lazabemide hydrochloride Ro 19-6327 hydrochloride	Monoamine Oxidase	Neurological Disease
Lazabemide hydrochloride (Ro 19-6327 hydrochloride) is a selective, reversible inhibitor of *monoamine oxidase* B (MAO-B) (IC₅₀**=0.03 μM) but less active for MAO-A (IC₅₀>100 μM). Lazabemide inhibits monoamine uptake at high concentrations, the IC₅₀ values are 86 μM, 123 μM and >500 μM for noradrenalin, serotonin and dopamine uptake, respectively. Lazabemide can be used for the research of parkinson and alzheimer′s disease.

HY-14201

Lazabemide Ro 19-6327	Monoamine Oxidase	Neurological Disease
Lazabemide (Ro 19-6327) is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) (IC₅₀=0.03 μM) but less active for MAO-A (IC₅₀>100 μM). Lazabemide inhibits monoamine uptake at high concentrations, the IC₅₀ values are 86 μM, 123 μM and >500 μM for noradrenalin, serotonin and dopamine uptake, respectively. Lazabemide can be used for the research of parkinson and alzheimer′s disease.

HY-N1638

1-Methyl-2-undecyl-4(1H)-quinolone	Monoamine Oxidase	Neurological Disease
1-Methyl-2-undecyl-4(1H)-quinolone is a potent, irreversible and selective inhibitor of type B monoamine oxidase (MAO-B). 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of MAO-B activity with the IC₅₀ and K_i values of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity. Methyl-2-undecyl-4(1H)-quinolone, as a quinolone alkaloid, is isolated from fresh leaves and fruits of Evodia rutaecarpa HOOK. f. et THOMS.

HY-13929

Isocarboxazid	Monoamine Oxidase	Neurological Disease
Isocarboxazid is a non-selective and irreversible inhibitor of monoamine oxidase, with an IC₅₀ of 4.8 μM for rat brain monoamine oxidase in vitro.

HY-W001601

Budipine	iGluR	Neurological Disease
Budipine is an anti-parkinson agent. Budipine also is a substrate of P-glycoprotein (P-gp), is mediated the uptake into the brain by P-gp. Budipine also is N-methyl-d-aspartate (NMDA) antagonist, and has indirect dopaminergic effects through an improved dopamine release, the inhibition of monoamine oxidase type B (MAO-B). Budipine can be used for the research of CNS disorders include Parkinson disease.

HY-146383

H3R antagonist 2	Histamine Receptor Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
H3R antagonist 2 (Compound 23) is a multitarget histamine H₃ receptor (H₃R) antagonist with a K_i of 170 nM for hH₃R . H3R antagonist 2 shows inhibitory effects with IC₅₀ values of 180, 880 and 775 nM for acetylcholinesterase, butyrylcholinesterase and *human monoamine oxidase* B (hMAO B)**, respectively. H3R antagonist 2 shows favorable anti-neuropathic pain and memory-enhancing effects. H3R can across BBB.

HY-13779

J-147	Monoamine Oxidase Dopamine Transporter	Neurological Disease
J-147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. J-147 can readily pass the blood brain barrier (BBB). J-147 can inhibit *monoamine oxidase* B (MAO B) and the dopamine transporter with EC₅₀** values of 1.88 μM and 0.649 μM, respectively. J-147 has potential for the treatment of Alzheimer’s disease (AD).

HY-W007584

2,4-Dimethoxybenzyl alcohol	Others	Others
2,4-Dimethoxybenzyl alcohol, an aromatic alcohol, is a substrate of glucose-methanol-choline (GMC) oxidoreductase. GMC oxidoreductase displays the characteristics of an aryl-alcohol oxidase.

HY-16677A

Mofegiline hydrochloride MDL72974A	Monoamine Oxidase	Neurological Disease
Mofegiline hydrochloride (MDL72974A) is an orally active and selective enzyme-activated irreversible inhibitor of MAO-B, with marked selectivity on the MAO-B over MAO-A with IC₅₀s of 3.6 nM (MAO-B) and 680 nM (MAO-A), respectively. Mofegiline hydrochloride is also an inhibitor of semicarbazide-sensitive amine oxidase (SSAO).

HY-12804

VAS2870
NADPH Oxidase Cardiovascular Disease

VAS2870 is a NADPH oxidase (NOX) inhibitor.
HY-139647

(+)-Cinchonaminone
Monoamine Oxidase Others

(+)-Cinchonaminone shows monoamine oxidase (MAO) inhibitory activity.
HY-B1413

Eprobemide
LIS 630
Monoamine Oxidase Neurological Disease

Eprobemide is a non-competitive reversible inhibitor of monoamine oxidase A.

HY-146314

MAO-B-IN-9	Monoamine Oxidase Amyloid-β	Neurological Disease
MAO-B-IN-9 (compound 16) is a potent, selective, BBB-penetrated, irreversible and time-dependent MAO-B (monoamine oxidase B) inhibitor, with an IC₅₀ of 0.18 μM. MAO-B-IN-9 prevents Aβ_1-42-induced neuronal cell death. MAO-B-IN-9 shows neuroprotective effects, which may be the result of its Aβ_1-42 anti-aggregation effects.

HY-101392

Harmane	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor	Cancer Neurological Disease
Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of *monoamine oxidase* (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B**, respectively). Harmane exhibits comutagenic effect.

HY-N0088

Apocynin
Acetovanillone
Autophagy Apoptosis Cancer

Apocynin is a selective NADPH-oxidase inhibitor with an IC₅₀ of 10 μM.
HY-136426

Trifludimoxazin
Others Others

Trifludimoxazin is a protoporphyrinogen oxidase inhibiting (PPO) herbicide.
HY-N9330

Broussoflavonol F
Xanthine Oxidase Others

Broussoflavonol F possess xanthine oxidase inhibitory activity.
HY-Y0127

D(-)-2-Aminobutyric acid
Endogenous Metabolite Others

D(-)-2-Aminobutyric acid is a substrate of D-amino acid oxidase.

HY-111588

Xanthoangelol	Apoptosis Monoamine Oxidase Bacterial AMPK	Cancer Infection Inflammation/Immunology
Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses. Xanthoangelol possesses antibacterial activity. Xanthoangelol inhibits monoamine oxidases. Xanthoangelol induces apoptosis in neuroblastoma and leukemia cells.

HY-P1120

WKYMVM	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
WKYMVM is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase.

HY-P1120A

WKYMVM TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
WKYMVM (TFA) is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase.

HY-22385A

Salsolidine hydrochloride	Monoamine Oxidase	Neurological Disease
Salsolidine hydrochloride, a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive *MAO A (monoamine oxidase* A)** inhibitor.

HY-17447

Tranylcypromine
SKF 385
Monoamine Oxidase Endocrinology Cardiovascular Disease

Tranylcypromine (SKF 385) is a potent monoamine oxidase (MAO) inhibitor.

HY-Q36392

JNJ-9350	Histone Demethylase	Cancer
JNJ-9350 is an inhibitor of spermine oxidase (SMOX) with an IC₅₀ value of 0.01 μM. JNJ-9350 also inhibits polyamine oxidase (PAO) with an IC₅₀ value of 0.79 μM. JNJ-9350 can be used for the research of cancer.

HY-U00015

MAO-IN-1
Monoamine Oxidase Neurological Disease

MAO-IN-1 is a monoamine oxidase B (MAO B) inhibitor with an IC₅₀ of 20 nM.

HY-P1121A

WKYMVM-NH2 TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase.

HY-143721

SSAO inhibitor-2	Monoamine Oxidase	Metabolic Disease Cardiovascular Disease Inflammation/Immunology
SSAO inhibitor-2 (Compound 1) is a semicarbazide-sensitive amine oxidase (SSAO) inhibitor with IC₅₀s of <10 nM, and 10-100 μM for human SSAO and MAO-A, respectively. SSAO inhibitor-3 can be used for the research of atherosclerosis, diabetes and its complications, obesity, stroke, chronic kidney disease, retinopathy, chronic obstructive pulmonary disease (COPD), autoimmune diseases, multiple sclerosis, etc.

HY-B1199

Nialamide	Monoamine Oxidase	Neurological Disease
Nialamide is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant.

HY-100178

CX-157
Monoamine Oxidase Neurological Disease

CX-157 is a reversible inhibitor of monoamine oxidase-A (MAO-A) with an EC₅₀ of 19.3 ng/mL.
HY-141859

PPO-IN-1
Others Others

PPO-IN-1 is a potent protoporphyrinogen IX oxidase (PPO) inhibitor with a K_i value of 2.5 nM.
HY-13339

Brofaromine
CGP 11305A
Monoamine Oxidase Neurological Disease

Brofaromine (CGP 11305A) is a monoamine oxidase (MAO) inhibitor with IC₅₀ of 0.2 μM for MAO-A.
HY-U00343

MAO-B-IN-1
Monoamine Oxidase Neurological Disease

MAO-B-IN-1 is an inhibitor of monoamine oxidase B, used for the research of neurological diseases.

HY-12903

Macozinone PBTZ169	Bacterial Antibiotic	Infection
Macozinone (PBTZ169) is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2′-oxidase) inhibitor. Macozinone inhibits the essential flavoprotein DprE1 by forming a covalent bond with the active-site Cys387 residue. Macozinone has antituberculosis effect.

HY-143723

SSAO inhibitor-3	Monoamine Oxidase	Metabolic Disease Cardiovascular Disease Inflammation/Immunology
SSAO inhibitor-3 (Compound 2) is a semicarbazide-sensitive amine oxidase (SSAO) inhibitor with IC₅₀s of <10 nM, and 0.1-10 μM for human SSAO and AOC1, respectively. SSAO inhibitor-3 can be used for the research of atherosclerosis, diabetes and its complications, obesity, stroke, chronic kidney disease, retinopathy, chronic obstructive pulmonary disease (COPD), autoimmune diseases, multiple sclerosis, etc.

HY-14197A

Clorgyline hydrochloride	Monoamine Oxidase	Metabolic Disease
Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research; structurally related to Pargyline.

HY-119885A

(±)-Amiflamine
FLA 336
Monoamine Oxidase Neurological Disease

(±)-Amiflamine (FLA 336) is a potent monoamine oxidase-A (MAO-A) inhibitor with a pIC₅₀ of 5.57.
HY-148145

Mebanazine
Monoamine Oxidase Neurological Disease

Mebanazine is a potent monoamine oxidase (MAO) inhibitor. Mebanazine can be used in research of depression.
HY-148146

Phenoxypropazine
Monoamine Oxidase Neurological Disease

Phenoxypropazine is a potent monoamine oxidase (MAO) inhibitor. Phenoxypropazine can be used in research of depression.
HY-14196

Toloxatone
MD 69276
Monoamine Oxidase Neurological Disease

Toloxatone (MD 69276) is a reversible monoamine oxidase A (MAO_A) inhibitor. Antidepressant.

HY-135425

10,12-Tricosadiynoic acid	Acyltransferase	Metabolic Disease
10,12-Tricosadiynoic acid is a highly specific, selective, high affinity and orally active *acyl-CoA oxidase-1 (ACOX1)* inhibitor. 10,12-Tricosadiynoic acid can treat high fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism.

HY-106235

LB80317	HBV DNA/RNA Synthesis	Infection
LB80317 is an active metabolite of LB80380 and suppresses the DNA synthesis of HBV with an EC₅₀ of 0.5 μM. LB80317 has antiviral effect and has the potential for chronic hepatitis B treatment.

HY-B0831

Buprofezin	Reactive Oxygen Species	Others
Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase.

HY-N0196

Baicalein 5,6,7-Trihydroxyflavone	Xanthine Oxidase Influenza Virus Ferroptosis	Cancer
Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC₅₀ value of 3.12 μM.

HY-N3906

Fraxamoside
Xanthine Oxidase Metabolic Disease

Fraxamoside is a competitive xanthine oxidase inhibitor with an IC₅₀ of 16.1 μM and a K_i of 0.9 μM.

HY-I0637

Isovanillin 3-Hydroxy-4-methoxybenzaldehyde	Others	Metabolic Disease Neurological Disease
Isovanillin is an aldehyde oxidase inhibitor. Antispasmodic activities. Antidiarrheal activities.

HY-14268S

Febuxostat D9
Xanthine Oxidase Cancer

Febuxostat-d₉ is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
HY-111412

DAAO inhibitor-1
Others Neurological Disease

DAAO inhibitor-1 is a potent D-amino acid oxidase (DAAO) inhibitor with an IC₅₀ of 0.12 μM.

HY-12298

Setanaxib GKT137831; GKT831	NADPH Oxidase Ferroptosis	Cardiovascular Disease
Setanaxib (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with K_is of 140 and 110 nM, respectively.

HY-B0051

Carbazeran	Phosphodiesterase (PDE)	Metabolic Disease
Carbazeran, a potent phosphodiesterase inhibitor, is aldehyde oxidase substrate. Carbazeran can be used for the research of metabolic disease.

HY-151340

Antitubercular agent-32	Bacterial	Infection
Antitubercular agent-32 is a derivate of Benzothiazinone (HY-13579A), inhibits M. tuberculosis, and shows improved metabolic stability and enhanced water solubility. Antitubercular agent-32 exerts antitubercular effect by targeting decaprenylphosphoryl-β-D-ribose 2’-oxidase (DprE1, IC₅₀=3.9 μM).

HY-B0886A

Iproniazid	Monoamine Oxidase	Neurological Disease
Iproniazid is a non-selective, irreversible *monoamine oxidase* (MAO)** inhibitor of the hydrazine class. Iproniazid has antidepressive activity.

HY-Y0882

Hydroxyamine hydrochloride	Monoamine Oxidase	Cardiovascular Disease
Hydroxyamine hydrochloride is a selective *monoamine oxidase* (MAO)** inhibitor used for inhibiting of platelet aggregation. Hydroxyamine hydrochloride is an intermediate of organic synthesis.

HY-B1135

Benzbromarone	Xanthine Oxidase Apoptosis	Metabolic Disease
Benzbromarone is a highly effective and well tolerated non-competitive inhibitor of xanthine oxidase, used as an uricosuric agent, used in the treatment of gout.

HY-131268

O-Desisobutyl-O-n-propyl Febuxostat
Xanthine Oxidase Metabolic Disease

O-Desisobutyl-O-n-propyl Febuxostat, extracted from the patent CN 103467412, is an xanthine oxidase inhibitor.

HY-B0886

Iproniazid phosphate	Monoamine Oxidase	Neurological Disease
Iproniazid phosphate is a non-selective, irreversible *monoamine oxidase* (MAO)** inhibitor of the hydrazine class. Iproniazid phosphate has antidepressive activity.

HY-W004570

5-Nitro-1,10-phenanthroline 5-NP	Endogenous Metabolite	Infection
5-Nitro-1,10-phenanthroline (5-NP), is a o-Phenanthroline (HY-W004544) derivative, as a mediator of glucose oxidase (GOX) with antituberculous activity. 5-Nitro-1,10-phenanthroline can be applied as redox mediators for oxidases and is suitable for the development of reagent-less biosensors and biofuel cells.

HY-117833

PXS-4681A	Monoamine Oxidase	Inflammation/Immunology
PXS-4681A is a potent, selective, irreversible and orally active *semicarbazide-sensitive amine oxidase* (SSAO; VAP-1) inhibitor with a K_i** of 37 nM. PXS-4681A shows highly selectivity over related amine oxidases, ion channels, and seven-transmembrane domain receptors. PXS-4681A has anti-inflammatory effects.

HY-101578

2614W94	Monoamine Oxidase	Neurological Disease
2614W94 is a selective, reversible inhibitor of monoamine oxidase-A with a competitive mechanism of inhibition and IC₅₀ of 5 nM and K_i of 1.6 nM with serotonin as substrate.

HY-W011258

H-Tyr-Phe-OH L-Tyrosyl-L-phenylalanine	Xanthine Oxidase Angiotensin-converting Enzyme (ACE)	Cancer Inflammation/Immunology
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells.

HY-B0831S

Buprofezin-d6	Reactive Oxygen Species	Metabolic Disease
Buprofezin-d₆ is the deuterium labeled Buprofezin. Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase[1][2].

HY-109183

Luvadaxistat
TAK-831
Others Others

TAK-831 is a highly selective and potent inhibitor of D-amino acid oxidase (DAAO) and can be used in studies of schizophrenia.

HY-14268S1

Febuxostat-d7 TEI 6720-d₇; TMX 67-d₇	Xanthine Oxidase	Metabolic Disease Cancer
Febuxostat-d₇ is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is selective xanthine oxidase inhibitor with a Ki of 0.6 nM[1].

HY-B2010

Fomesafen	Others	Others
Fomesafen is a type of efficient and selective *protoporphyrinogen IX oxidase* (PPO)** inhibitor. Fomesafen is a herbicide and has the advantages of low toxicity and high selectivity.

HY-151498

PXS-4787	Monoamine Oxidase	Others
PXS-4787 is a specific and effective pan-LOX (lysyl oxidase) inhibitor for abolishing lysyl oxidase activity. PXS-4787 inhibits LOX with IC₅₀s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), 0.2 μM (rh LOXL4), respectively.

HY-100621

MDL 72527 dihydrochloride	Others	Neurological Disease
MDL 72527 dihydrochloride is a potent *polyamine oxidase* (PAO)** inhibitor. MDL 72527 dihydrochloride shows a lysosomotropic effect. MDL 72527 dihydrochloride shows neuroprotective effects.

HY-19657

Oxypurinol Oxipurinol	Endogenous Metabolite Xanthine Oxidase	Metabolic Disease Inflammation/Immunology
Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout.

HY-148158

Pivalylbenzhydrazine Pivhydrazine	Monoamine Oxidase	Inflammation/Immunology Neurological Disease
Pivalylbenzhydrazine (Pivhydrazine) is a potent *monoamine oxidase* (MAO)** inhibitor. Pivalylbenzhydrazine decreases cartilage growth in normal rats. Pivalylbenzhydrazine can be used in research of depression.

HY-100965

Diphenyleneiodonium chloride DPI	TRP Channel NADPH Oxidase Reactive Oxygen Species	Inflammation/Immunology Neurological Disease
Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC₅₀ of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.

HY-108844

Rasburicase	Endogenous Metabolite	Metabolic Disease
Rasburicase is a recombinant urate oxidase and a hyperuricemia inhibitor. Rasburicase converts uric acid into allantoin, making it easier to be cleared by the kidneys and improving the elevated level of uric acid in the blood.

HY-N0088S

Apocynin-d3 Acetovanillone-d₃	Apoptosis Autophagy	Cancer
Apocynin-d₃ is the deuterium labeled Apocynin[1]. Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[2][3][4].

HY-B1111

Amitraz BTS-27419	Adrenergic Receptor Monoamine Oxidase Parasite	Infection Endocrinology
Amitraz is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.

HY-17531

Pyraclonil	Others	Others
Pyraclonil is a *proporphyrinogen oxidase* (PPO)** inhibitor. Pyraclonil is a herbicide agent and is highly effective in controlling the susceptible (S) and multiple-herbicide-resistant (MHR) E. indica populations.

HY-100111

GLX351322	NADPH Oxidase	Metabolic Disease
GLX351322 is an inhibitor of NADPH oxidase 4 (Nox4), and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC₅₀ of 5 μM.

HY-142706

MAO A/HDAC-IN-1
Monoamine Oxidase HDAC Cancer

MAO A/HDAC-IN-1 is a dual inhibitor of monoamine oxidase A (MAO A) and HDAC. MAO A/HDAC-IN-1 can be used for glioma research.

HY-B1041

Aminoguanidine hydrochloride Pimagedine hydrochloride; GER-11; Aminoguanidinium chloride	NO Synthase	Endocrinology
Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, reduces levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone, is an investigational drug for the treatment of diabetic nephropathy.

HY-135745

Sulfentrazone	Others	Others
Sulfentrazone is a phenyl triazolinone herbicide used for control of certain broadleaf and grass weed species. Sulfentrazone inhibits protoporphyrinogen oxidase, resulting in the disruption of lipid cell membranes.

HY-N1547

Prudomestin	Xanthine Oxidase	Inflammation/Immunology
Prudomestin, isolated from the heartwood of Prunus domestica, shows potent *xanthine oxidase* (XO)** inhibitory activity (IC₅₀≈6 µM).

HY-N7603

Rubrofusarin triglucoside	Monoamine Oxidase	Neurological Disease
Rubrofusarin triglucoside is a glycoside compound isolated from Cassia obtusifolia Linn seeds. Rubrofusarin triglucoside inhibits *human monoamine oxidase* A (hMAO-A) with an IC₅₀** of 85.5 μM.

HY-15386

Cimoxatone MD 780515	Monoamine Oxidase	Metabolic Disease
Cimoxatone (MD 780515) is a reversible, selectively and orally active *type A monoamine oxidase* (MAO-A)** inhibitor. Cimoxatone enhances the anorectic action of Serotonin (HY-B1473A).

HY-139585

Tigulixostat LC350189	Xanthine Oxidase	Metabolic Disease
Tigulixostat (LC350189) is an orally active, non-purine selective xanthine oxidase inhibitor. Tigulixostat lowers the production of uric acid. Tigulixostat can be used for gout and hyperuricemia study.

HY-I0637S

Isovanillin-d3 3-Hydroxy-4-methoxybenzaldehyde-d₃	Isotope-Labeled Compounds
Isovanillin-d₃ is the deuterium labeled Isovanillin[1]. Isovanillin is an aldehyde oxidase inhibitor[2]. Antispasmodic activities[3]. Antidiarrheal activities[4].

HY-108537

L 012 sodium salt	Reactive Oxygen Species	Inflammation/Immunology
L 012 sodium salt a luminol-based chemiluminescent (CL) probe, is widely used in vitro and in vivo to detect NADPH oxidase (Nox)-derived superoxide (O2^•−) and identify Nox inhibitors.

HY-22385B

(S)-Salsolidine	Monoamine Oxidase Endogenous Metabolite	Neurological Disease
(S)-Salsolidine is a weak *monoamine oxidase* (MAO) inhibitor (K_i**=63 μM). The R enantiomer of Salsolidine is more potent than the S form (K_i=26 μM).

HY-14268A

Febuxostat sodium TEI 6720 sodium; TMX 67 sodium	Xanthine Oxidase	Metabolic Disease Cardiovascular Disease
Febuxostat (TEI 6720) sodium is a potent, selective and non-purine *xanthine oxidase* (XO) inhibitor with a K_i** value of 0.6 nM. Febuxostat sodium has the potential for the research of hyperuricemia and gout.

HY-14268

Febuxostat TEI 6720; TMX 67	Xanthine Oxidase	Metabolic Disease Cardiovascular Disease
Febuxostat (TEI 6720) is a potent, selective and non-purine *xanthine oxidase* (XO) inhibitor with a K_i** value of 0.6 nM. Febuxostat has the potential for the research of hyperuricemia and gout.

HY-14605BS

Rasagiline-13C3 mesylate racemic AGN1135-¹³C₃; TVP1012-¹³C₃ racemic	Monoamine Oxidase	Neurological Disease
Rasagiline-¹³C₃ (mesylate racemic) is a ¹³C-labeled Rasagiline mesylate racemic. Rasagiline mesylate racemic is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor[1].

HY-P1118

Ac9-25	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Ac9-25, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR.

HY-W038985

1,3-Oxazolidine-2-thione	Others	Metabolic Disease
1,3-Oxazolidine-2-thione, a free oxazolidinethione, increases thyroid size and severely depresses hepatic trimethylamine oxidase activity in the brown-egg layers.

HY-147362

MAO-B-IN-14	Monoamine Oxidase	Neurological Disease
MAO-B-IN-14 (Compound 9) is a potent and selective monoamine oxidase-B (MAO-B) inhibitor with an IC₅₀ of 0.95 μM and a K_i of 0.55 μM against human MAO-B.

HY-A0091

Pargyline hydrochloride	Monoamine Oxidase	Cancer Cardiovascular Disease
Pargyline hydrochloride is an irreversible *monoamine oxidase* (MAO) inhibitor with K_is of 13 μM and 0.5 μM for MAO-A and MAO-B**, respectively. Pargyline hydrochloride has antihypertensive and anticancer activities.

HY-P1118A

Ac9-25 TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Ac9-25 TFA, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR.

HY-A0091A

Pargyline	Monoamine Oxidase	Cancer Cardiovascular Disease
Pargyline is an irreversible *monoamine oxidase* (MAO) inhibitor with K_is of 13 μM and 0.5 μM for MAO-A and MAO-B**, respectively. Pargyline has antihypertensive and anticancer activities.

HY-139607

SSAO inhibitor-1	Monoamine Oxidase	Inflammation/Immunology
SSAO inhibitor-1 is a semicarbazide-sensitive amine oxidase (SSAO) inhibitor. SSAO inhibitor-1 has anti-inflammatory activity and can be used for liver diseases research.

HY-Y0127S

D(-)-2-Aminobutyric acid-d6	Endogenous Metabolite
D(-)-2-Aminobutyric acid-d₆ is the deuterium labeled D(-)-2-Aminobutyric acid. D(-)-2-Aminobutyric acid is a substrate of D-amino acid oxidase.

HY-17447B

(1S,2R)-Tranylcypromine hydrochloride (1S,2R)-SKF 385 hydrochloride	Monoamine Oxidase Histone Demethylase	Neurological Disease
(1S,2R)-Tranylcypromine ((1S,2R)-SKF 385) hydrochloride is a potent antidepressant agent. (1S,2R)-Tranylcypromine hydrochloride can inhibits MAO and LSD1.

HY-W037417

DAO-IN-1	Others	Others
DAO-IN-1 is a potent inhibitor of D-amino acid oxidase (DAO) with an IC₅₀ value of 269 nM. DAO is an enzyme responsible for D-serine metabolism, D-serine is a co-agonist of NMDA receptors.

HY-N9324

Ilexoside O	Xanthine Oxidase	Inflammation/Immunology
Ilexoside O is a triterpene saponin isolated from the roots of Ilex pubescens. Ilexoside O exhibits weak *xanthine oxidase* (XOD)** inhibitory activity (IC₅₀=53.05 μM).

HY-Y0882S1

Hydroxylamine-d3 hydrochloride	Monoamine Oxidase	Cardiovascular Disease
Hydroxylamine-d₃ (hydrochloride) is the deuterium labeled Hydroxyamine hydrochloride[1]. Hydroxyamine hydrochloride is a selective monoamine oxidase (MAO) inhibitor used for inhibiting of platelet aggregation. Hydroxyamine hydrochloride is an intermediate of organic synthesis[2].

HY-146149

MAO-B-IN-11	Monoamine Oxidase	Neurological Disease
MAO-B-IN-11 (Compound 8c) is a potent monoamine oxidase B (MAO-B) inhibitor with an IC₅₀ of 1.3 μM. MAO-B-IN-11 shows a neuroprotective activity.

HY-N10863

Aurantiamide benzoate	Xanthine Oxidase	Infection
Aurantiamide benzoate is a nature product that could be isolated from two tropical medicinal plants, Cunila spicata and Hyptis fasciculata. Aurantiamide benzoate is a potent xanthine oxidase inhiobitor with an IC₅₀ value of 70 μM.

HY-U00448

ADDA 5 hydrochloride	Others	Cancer
ADDA 5 hydrochloride is a partial non-competitive inhibitor of *cytochrome c oxidase* (CcO), with IC₅₀**s of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively.

HY-146150

MAO-B-IN-12	Monoamine Oxidase	Neurological Disease
MAO-B-IN-12 (Compound 16c) is a potent monoamine oxidase B (MAO-B) inhibitor with an IC₅₀ of 1.3 μM. MAO-B-IN-12 shows a neuroprotective activity.

HY-P1435A

NoxA1ds TFA	NADPH Oxidase
NoxA1ds TFA is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC₅₀=20 nM). NoxA1ds TFA exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. NoxA1ds TFA inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.

HY-13404A

Capmatinib dihydrochloride INC280 dihydrochloride; INCB28060 dihydrochloride	c-Met/HGFR Apoptosis	Cancer
Capmatinib (INC280; INCB28060) dihydrochloride is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC₅₀=0.13 nM). Capmatinib dihydrochloride can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride is largely metabolized by CYP3A4 and aldehyde oxidase.

HY-13404C

Capmatinib dihydrochloride hydrate INC280 dihydrochloride hydrate; INCB-28060 dihydrochloride hydrate	c-Met/HGFR Apoptosis	Cancer
Capmatinib (INC280; INCB28060) dihydrochloride hydrate is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC₅₀=0.13 nM). Capmatinib dihydrochloride hydrate can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride hydrate potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride hydrate is largely metabolized by CYP3A4 and aldehyde oxidase.

HY-13404

Capmatinib INC280; INCB28060	c-Met/HGFR Apoptosis	Cancer
Capmatinib (INC280; INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC₅₀=0.13 nM). Capmatinib can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib is largely metabolized by CYP3A4 and aldehyde oxidase.

HY-13404B

Capmatinib hydrochloride INC280 hydrochloride; INCB-28060 hydrochloride	c-Met/HGFR Apoptosis	Cancer
Capmatinib (INC280; INCB28060) hydrochloride is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC₅₀=0.13 nM). Capmatinib hydrochloride can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib hydrochloride potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib hydrochloride is largely metabolized by CYP3A4 and aldehyde oxidase.

HY-128075

Acifluorfen	Others	Cancer
Acifluorfen, a protoporphyrinogen oxidase (PROTOX) inhibitor herbicide, promotes the accumulation of protoporphyrin IX (PPIX), and induces tumors in the rodent liver. Acifluorfen causes strong photooxidative destruction of pigments and lipids in sensitive plant species.

HY-B1111S1

Amitraz-d3 BTS-27419-d₃	Adrenergic Receptor Monoamine Oxidase Parasite	Infection Endocrinology
Amitraz-d₃ is the deuterium labeled Amitraz. Amitraz is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.

HY-14605

Rasagiline mesylate (R)-AGN1135 mesylate; TVP1012 mesylate	Monoamine Oxidase Autophagy Apoptosis	Neurological Disease
Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively.

HY-14605A

Rasagiline (R)-AGN1135; TVP1012	Monoamine Oxidase	Neurological Disease
Rasagiline (R-AGN1135) is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively.

HY-128799A

CL097 hydrochloride	Toll-like Receptor (TLR) Reactive Oxygen Species	Inflammation/Immunology
CL097, a potent TLR7 and TLR8 agonist, induces pro-inflammatory cytokines in macrophages. CL097 induces NADPH oxidase priming, resulting in an increase of the fMLF-stimulated ROS production.

HY-B0219S

Allopurinol-d2	Xanthine Oxidase	Infection Inflammation/Immunology
Allopurinol-d₂ is deuterium labeled Allopurinol. Allopurinol is a potent xanthine oxidase inhibitor (IC50 values of 0.2 to 50 μM). Allopurinol can be used for the research of hyperuricemia and gout. Antileishmanial effect[1][2].

HY-128799

CL097	Toll-like Receptor (TLR) Reactive Oxygen Species	Inflammation/Immunology
CL097, a potent TLR7 and TLR8 agonist, induces pro-inflammatory cytokines in macrophages. CL097 induces NADPH oxidase priming, resulting in an increase of the fMLF-stimulated ROS production.

HY-12136

Purpurogallin	Xanthine Oxidase	Cancer Inflammation/Immunology Cardiovascular Disease
Purpurogallin is a naturally phenol extracted from the plants of Quercus spp, has potent *xanthine oxidase* (XO) inhibitory activity with an IC₅₀** of 0.2 µM. Purpurogallin has antioxidant and anti-inflammatory effects.

HY-N0699

Daphnoretin Dephnoretin; Thymelol	PKC Influenza Virus	Infection
Daphnoretin (Dephnoretin), isolated from Wikstroemia indica, possesses antiviral activity. Daphnoretin likes PMA, may direct activation of protein kinase C which in turn activated NADPH oxidase and elicited respiratory burst.

HY-137551

Tiafenacil	Others	Others
Tiafenacil is a new protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide, with IC₅₀ values of 22 to 28 nM for various plant species, including amaranth (Amaranthus tuberculatus), soybean (Glycine max), arabidopsis (Arabidopsis thaliana), and rapeseed (Brassica napus).

HY-111447

VAS 3947	NADPH Oxidase Apoptosis	Cancer Cardiovascular Disease
VAS 3947, a specific *NADPH oxidase* (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis** independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins.

HY-120017

Befloxatone MD-370503	Monoamine Oxidase	Neurological Disease
Befloxatone (MD-370503) is an orally active, selective and reversible inhibitor of *Monoamine Oxidase* A (MAO-A) (IC₅₀**=4 nM). Befloxatone increases the tissue level of monoamine, striatal dopamine and cortical norepinephrine. Befloxatone has antidepressant potential.

HY-148610

LDH-IN-2	Others	Metabolic Disease
LDH-IN-2, a salicylic acid derivative, is an inhibitor of glycolate oxidase (GO). LDH-IN-2 decreases oxalate output in hyperoxaluric hepatocytes. LDH-IN-2 can be used for research of primary hyperoxaluria type 1 (PH1).

HY-N2510

Myristicin Myristicine	5-HT Receptor	Neurological Disease
Myristicine act as a serotonin receptor antagonist, a weak *monamine oxidase* (MAO)** inhibitor. Myristicine is the main component of nutmeg essential oil from Myristica fragrans Houtt. Myristicine abuse produce hallucinogenic effects, organ damage, deliriumand others.

HY-151173

XO/COX/LOX-IN-1	Xanthine Oxidase Lipoxygenase COX	Cancer Metabolic Disease Inflammation/Immunology
XO/COX/LOX-IN-1 (compound 7i) is a potent xanthine oxidase/cyclooxygenases/lipoxygenases (XO/COX/LOX) inhibitor. XO/COX/LOX-IN-1 can be used in studies of inflammation, cancer and metabolic diseases.

HY-N3220

Myricetin 3-O-galactoside	Xanthine Oxidase	Metabolic Disease
Myricetin 3-O-galactoside inhibits *xanthine oxidase* (XO)** activity, lipid peroxidation and scavenges the free radical. Myricetin 3-O-galactoside inhibits lipid peroxidation with an IC₅₀ of 160 μg/mL. Antioxidant activity.

HY-N6057

Obtusin	Monoamine Oxidase	Neurological Disease
Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive *human monoamine oxidase-A (hMAO-A)* inhibitor with an IC₅₀ of 11.12 μM and a K_i of 6.15 μM. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression.

HY-12803

Fulvene-5	NADPH Oxidase Reactive Oxygen Species	Cancer
Fulvene-5 is a potent *NADPH oxidase* 4 (NOX4) inhibitor with antioxidant properties. Fulvene-5 is a reactive oxygen species (ROS)** modifying agent and a potent radioprotector. Fulvene-5 has antitumor activity.

HY-124674A

CCT365623 hydrochloride	Monoamine Oxidase EGFR Akt TGF-beta/Smad	Cancer
CCT365623 hydrochloride is an orally active *lysyl oxidase* (LOX) inhibitor, with an IC₅₀** of 0.89 μM. CCT365623 hydrochloride suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF. CCT365623 hydrochloride is extremely well tolerated, and has good pharmacokinetic properties.

HY-N8200

Cassiaside B2	Phosphatase Monoamine Oxidase 5-HT Receptor	Inflammation/Immunology
Cassiaside B2 is a protein tyrosine phosphatase 1B (PTP1B) and *human monoamine oxidase* A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a 5-HT2C** receptor agonist...

HY-19915

Contezolid MRX-I	Bacterial Antibiotic Monoamine Oxidase	Infection Inflammation/Immunology
Contezolid (MRX-I), a new and orally active oxazolidinone, is an antibiotic in study for complicated skin and soft tissue infections (cSSTI) caused by resistant Gram-positive bacteria. Contezolid (MRX-I) markedly reduces potential for myelosuppression and monoamine oxidase inhibition (MAOI).

HY-18950

GSK2795039	NADPH Oxidase Reactive Oxygen Species Apoptosis	Cancer
GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC₅₀ of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 reduces apoptosis.

HY-W015490S

1,4-Naphthoquinone-d6	Monoamine Oxidase	Cancer
1,4-Naphthoquinone-d₆ is the deuterium labeled 1,4-Naphthoquinone[1]. 1,4-Naphthoquinone is a potential pharmacophore for inhibition of both MAO (monoamine oxidase) and DNA topoisomerase activities, this latter associated with antitumor activity[2].

HY-B0534S1

Moclobemide-d4 Ro111163-d₄	Monoamine Oxidase	Neurological Disease
Moclobemide-d₄ is deuterium labeled Moclobemide. Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A[1].Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

HY-N2472

Medicagenic acid Castanogenin	Bacterial	Infection
Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes. Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE.

HY-P1116

PBP10	Bacterial	Infection Inflammation/Immunology
PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1. PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects.

HY-100027A

Ro 41-1049 hydrochloride	Monoamine Oxidase	Neurological Disease
Ro 41-1049 hydrochloride is a reversible and selective inhibitor of *monoamine oxidase-A (MAO-A). An homogeneous population of high affinity binding sites for [³H]Ro 41-1049 is found in membrane preparations from human frontal cortex and placenta (K_d* values of 16.5 and 64.4 nM, respectively).

HY-13735

Quinacrine Acriquine	Parasite Sodium Channel DNA Stain	Cancer Infection Neurological Disease
Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC₅₀: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm).

HY-12805

ML171 2-Acetylphenothiazine; 2-APT	NADPH Oxidase	Cardiovascular Disease
ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective NADPH oxidase 1 (Nox1) inhibitor that blocks Nox1-dependent ROS generation, with an IC₅₀ of 0.25 μM in HEK293-Nox1 confirmatory assay.

HY-W083062

hMAO-B-IN-5	Monoamine Oxidase	Neurological Disease
hMAO-B-IN-5(B15) is a potent, selective and reversible inhibitor of human monoamine oxidase hMAO-B with IC₅₀ of 0.12 μM. hMAO-B-IN-5 can pass through the blood-brain barrier and can be used in the research of neurodegenerative diseases.

HY-N10411

Morin 3-O-β-D-glucopyranoside	Reverse Transcriptase HIV Xanthine Oxidase	Cancer Infection Cardiovascular Disease
Morin 3-O-β-D-glucopyranoside is a natural flavonoid with antifungal, anticancer and antioxidant activities. Morin 3-O-β-D-glucopyranoside inhibits reverse transcriptase, protein-tyrosine kinase and xanthine oxidase, and also shows anti-HIV, antiarteriosclerotic, and superoxide scavenging activities.

HY-151094

FTEAA	Monoamine Oxidase	Neurological Disease
FTEAA is a 4-styrylpiperidine inhibitor. FTEAA exhibits potent inhibitory effect towards both monoamine oxidase with IC₅₀s of 0.52 μM (MAO-A), 1.02 μM (MAO-B), respectively. MAO inhibitors can be used for cardiovascular, neurological and oncological disorders research.

HY-B1496

Tranylcypromine hemisulfate SKF 385 hemisulfate	Monoamine Oxidase Histone Demethylase	Neurological Disease
Tranylcypromine (SKF 385) hemisulfate is an irreversible, nonselective *monoamine oxidase* (MAO) inhibitor used in the treatment of depression. Tranylcypromine hemisulfate is also a lysine-specific demethylase 1 (LSD1)** inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis. Tranylcypromine has antidepressant effects.

HY-17447SA

Tranylcypromine-d5 hydrochloride SKF 385-d₅ (hydrochloride)	Monoamine Oxidase Histone Demethylase	Neurological Disease
Tranylcypromine-d₅ (hydrochloride) is a deuterium labeled (rel)-Tranylcypromine hydrochloride. Tranylcypromine hydrochloride is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hydrochloride is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis[1][2].

HY-N4037

Homopterocarpin (-)-Homopterocarpin; 3,9-Dimethoxypterocarpan	Monoamine Oxidase	Inflammation/Immunology
Homopterocarpin is an isoflavonoid that can be isolated from Pterocarpus erinaceus. Homopterocarpin has hepatoprotective and antioxidant properties. Homopterocarpin is a competitive reversible inhibitor of human monoamine *oxidase-B* with an IC₅₀ and a K_i of 0.72 and 0.21 μM for hMAO-B, respectively. Homopterocarpin can be used for the research of liver injury and oxidative stress.

HY-120801

APX-115 Ewha-18278	NADPH Oxidase	Metabolic Disease Inflammation/Immunology
APX-115 (Ewha-18278) is a potent, orally active pan *NADPH oxidase* (Nox) inhibitor with K_i values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4**, respectively. APX-115 effectively prevents kidney injury.

HY-N7204

4-Hydroxyderricin	Monoamine Oxidase Dopamine β-hydroxylase	Neurological Disease
4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is a potent selective *MAO-B (Monoamine oxidase* inhibitors) inhibitor with an IC₅₀ of 3.43 μM. 4-Hydroxyderricin also mildly inhibits DBH (dopamine β-hydroxylase)** activity. 4-Hydroxyderricin has antidepressant activity.

HY-N0814B

Phytic acid hexasodium Inositol hexaphosphate hexasodium	Endogenous Metabolite	Inflammation/Immunology Neurological Disease
Phytic acid (Inositol hexaphosphate) hexasodium is a phosphorus storage compound of seeds and cereal grains. Phytic acid hexasodium has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid hexasodium inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.

HY-146312

AChE/BChE/MAO-B-IN-1	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
AChE/BChE/MAO-B-IN-1 (Compound 10) is a reversible and non-time-dependent AChE, BChE and MAO-B inhibitor with IC₅₀ values of 7.31, 0.56 and 26.1 μM for hAChE, hBChE and hMAO-B, respectively. AChE/BChE/MAO-B-IN-1 can cross the BBB and shows neuroprotective effects without cytotoxicity.

HY-N2554

Osthenol Ostenol	Monoamine Oxidase	Neurological Disease
Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (K_i=0.26 µM). Osthenol potently inhibits recombinant hMAO-A with an IC₅₀ of 0.74 µM and shows a high selectivity index for hMAO-A versus hMAO-B.

HY-15929

TBHBA 2,4,6-Tribromo-3-hydroxybenzoic acid	Biochemical Assay Reagents	Others
The Boehringer Mannheim cholesterol esterase/cholesterol oxidase/peroxidase/3,4-dichlorophenol kinetic reagent was modified by the inclusion of TBHBA (2,4,6-Tribromo-3-hydroxybenzoic acid) which reacts with hydrogen peroxide and 4-aminophenazone to produce a quinone-imine dye with a greater molar absorptivity than that produced with phenol.

HY-P1435

NoxA1ds	NADPH Oxidase	Cardiovascular Disease
NoxA1ds is a highly efficacious and selective Nox1 (NADPH oxidase isoform 1) inhibitor. NoxA1ds establishes a critical interaction site for Nox1-NOXA1 binding required for enzyme activation. NoxA1ds can be used for the research of hypertension, atherosclerosis and neoplasia.

HY-130242

PXS-5120A	Monoamine Oxidase	Inflammation/Immunology
PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of *Lysyl Oxidase-like 2/3 (LOXL2/3)* with anti-fibrotic activity. PXS-5120A is >300-fold selective for LOXL2 (K_i of 83 nM; pIC₅₀ of 8.4) over LOXL (pIC₅₀ of 5.8).

HY-121246

Fluorofenidone AKF-PD	PI3K Akt	Inflammation/Immunology
Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway.

HY-P2890

Laccase Denilite IIS	Endogenous Metabolite	Others
Laccase (Denilite IIS) is a multi-copper oxidase (MCOs), which widely exists in microorganisms, plants and fungi, and can catalyze the oxidation of one electron of various phenolic compounds. Laccase can promote the oxidative coupling of single lignin, which plays an important role in the formation and biodegradation of lignin, and also has the potential to cross-link food polymers.

HY-N0814

Phytic acid Inositol hexaphosphate	Xanthine Oxidase Endogenous Metabolite	Inflammation/Immunology Neurological Disease
Phytic acid (Inositol hexaphosphate) is a phosphorus storage compound of seeds and cereal grains. Phytic acid is known as a food inhibitor, which has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.

HY-114286

PXS-5153A	Monoamine Oxidase	Inflammation/Immunology
PXS-5153A is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC₅₀ of <40 nM for LOXL2 across all mammalian species and an IC₅₀ of 63 nM for human LOXL3. PXS-5153A could reduce crosslinks and ameliorates fibrosis.

HY-142125

Broussochalcone A	Xanthine Oxidase Reactive Oxygen Species Apoptosis	Cancer Inflammation/Immunology
Broussochalcone A is an antioxidant and an inhibitor of Xanthine Oxidase (IC₅₀=2.21 μM), with free radical scavenging activity. Broussochalcone A inhibits iron-induced lipid peroxidation and nitric oxide synthesis in lipopolysaccharide (LPS) -activated macrophages. Broussochalcone A also induces Apoptosis of human renal carcinoma cells by increasing ROS levels and activating FOXO3 signaling pathways.

HY-120801A

APX-115 free base Ewha-18278 free base; Isuzinaxib free base	NADPH Oxidase	Endocrinology Inflammation/Immunology
APX-115 free base (Ewha-18278 free base) is a potent, orally active pan *NADPH oxidase* (Nox) inhibitor with K_i values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4**, respectively. APX-115 free base effectively prevents kidney injury.

HY-10400

Ladostigil hemitartrate TV-3326 hemitartrate	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
Ladostigil (TV-3326) hemitartrate is an orally active dual inhibitor of cholinesterase and brain-selective *monoamine oxidase* (MAO), with IC₅₀s of 37.1 and 31.8 μM for MAO-B and AChE**, respectively. Ladostigil hemitartrate exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil hemitartrate can be used for the research of depression and Alzheimer's disease.

HY-17447A

Tranylcypromine hydrochloride SKF 385 hydrochloride	Monoamine Oxidase	Neurological Disease
Tranylcypromine hydrochloride (SKF 385 hydrochloride) is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Tranylcypromine hydrochloride inhibits LSD1, MAO A and MAO B with IC₅₀s of 20.7, 2.3 and 0.95 μM, respectively. Tranylcypromine hydrochloride can be used for the research of depression.

HY-114286A

PXS-5153A monohydrochloride	Monoamine Oxidase	Inflammation/Immunology
PXS-5153A monohydrochloride is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC₅₀ of <40 nM for LOXL2 across all mammalian species and an IC₅₀ of 63 nM for human LOXL3. PXS-5153A monohydrochloride could reduce crosslinks and ameliorates fibrosis.

HY-N0814A

Phytic acid dodecasodium hydrate Inositol hexaphosphate dodecasodium hydrate	Xanthine Oxidase Endogenous Metabolite	Inflammation/Immunology Neurological Disease
Phytic acid (Inositol hexaphosphate) dodecasodium hydrate is a phosphorus storage compound of seeds and cereal grains. Phytic acid dodecasodium hydrate is known as a food inhibitor, which has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid dodecasodium hydrate inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.

HY-B0219A

Allopurinol sodium	Xanthine Oxidase	Cancer Infection Inflammation/Immunology Neurological Disease
Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC₅₀ value of 0.2-50 μM. Allopurinol sodium can be used in the research of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect.

HY-Y0265

Isatin Indoline-2,3-dione	Monoamine Oxidase Apoptosis	Cancer Neurological Disease Cardiovascular Disease
Isatin (Indoline-2,3-dione) is a potent inhibitor of *monoamine oxidase* (MAO) with an IC₅₀ of 3 μM. Also binds to central benzodiazepine receptors (IC₅₀ against clonazepam, 123 μM). Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase** activity. Shows effect on the serotonergic system.

HY-D0004

Azure B Azure B chloride	Monoamine Oxidase	Neurological Disease
Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of *monoamine oxidases* (MAO)-A, with IC₅₀**s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects.

HY-B0219

Allopurinol	Xanthine Oxidase	Cancer Infection Inflammation/Immunology Neurological Disease
Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC₅₀ value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect.

HY-146347

MAO-B-IN-10	Monoamine Oxidase Amyloid-β	Neurological Disease
MAO-B-IN-10 (compound 4f) is a potent, selective, BBB-penetrated MAO-B (monoamine oxidase-B) inhibitor, with IC₅₀ of 5.3 μM. MAO-B-IN-10 can inhibit (58.2%) and disaggregate (43.3%) self-mediated Aβ (amyloid β) aggregation. MAO-B-IN-10 can be use for Alzheimer’s disease research.

HY-121246S

Fluorofenidone-d3 AKF-PD-d₃	PI3K Akt Isotope-Labeled Compounds	Inflammation/Immunology
Fluorofenidone-d₃ is deuterium labeled Fluorofenidone. Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway[1][2].

HY-125863

Glucose-6-phosphate dehydrogenase	Endogenous Metabolite	Cancer Metabolic Disease
Glucose-6-phosphate dehydrogenase is the rate-limiting enzyme of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase is a major source of NADPH that is required by many essential cellular systems including the antioxidant pathways, nitric oxide synthase, NADPH oxidase, cytochrome p450 system, and others. Glucose-6-phosphate dehydrogenase can be used for the research of diabetes, aldosterone-induced endothelial dysfunction, and cancer.

HY-107422A

Lenumlostat hydrochloride PAT-1251 hydrochloride; GB2064 hydrochloride	Monoamine Oxidase	Inflammation/Immunology
PAT-1251 Hydrochloride is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC₅₀s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC₅₀s, 0.10, 0.12, and 0.16 μM, respectively). PAT-1251 Hydrochloride is used in the research of fibrotic diseases.

HY-B1359

Methylene blue trihydrate C.I. Basic Blue 9 trihydrate	Guanylate Cyclase Monoamine Oxidase NO Synthase Parasite	Cancer Infection Neurological Disease
Methylene blue trihydrate (C.I. Basic Blue 9 trihydrate) is a guanylyl cyclase (sGC), *monoamine oxidase* A (MAO-A) and NO synthase (NOS)** inhibitor. Methylene blue trihydrate is a vasopressor and is often used as a dye in several medical procedures. Methylene blue trihydrate has antinociception, antimalarial, antidepressant and anxiolytic activity effects. Methylene Blue trihydrate has the potential for methemoglobinemias, neurodegenerative disorders and ifosfamide-induced encephalopathytreatment.

HY-141508

Flazin	Xanthine Oxidase NO Synthase	Metabolic Disease Inflammation/Immunology Neurological Disease
Flazin is a non-enzymatic protein glycation inhibitor, also inhibits peroxynitrite (ONOO^-), with an IC₅₀ value of 85.31 μM for bovine serum albumin (BSA) glycation and an EC₅₀ value of 71.99 μM for ONOO^-. Flazin can be used for researching diabetes and neuronal disorders. Flazin also can used as a lipid droplet (LD) regulator against lipid disorders, and a *xanthine oxidase* (XOD)** inhibitor.

HY-126213

1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium 18:1 Lyso-PS	Others	Inflammation/Immunology
Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (18:1 Lyso-PS) is a modified PS product generated following activation of the NADPH oxidase and lyso-PS signaling. Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium through the macrophage G2A functions to enhance existing receptor/ligand systems for resolution of neutrophilic inflammation.

HY-107422

Lenumlostat PAT-1251; GB2064	Monoamine Oxidase	Inflammation/Immunology
PAT-1251 is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC₅₀s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC₅₀s, 0.10, 0.12, and 0.16 μM, respectively); PAT-1251 is used in the research of fibrotic diseases.

HY-152671

hMAO-B-IN-4	Monoamine Oxidase	Neurological Disease
hMAO-B-IN-4 (compound B10) is a selective, reversible and blood–brain barrier (BBB) penetrable human monoamine oxidase-B (hMAO-B) inhibitor with an IC₅₀ value and a K_i value of 0.067 and 0.03 μM, respectively. hMAO-B-IN-4 inhibits hMAO-A with an IC₅₀ value of 33.82 μM. hMAO-B-IN-4 can be used for Alzheimer’s disease (AD) and Parkinson’s disease (PD) research.

HY-N6947

Lutein Xanthophyll	Endogenous Metabolite Apoptosis Reactive Oxygen Species	Inflammation/Immunology Neurological Disease
Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health. Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS). Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active.

HY-151499

PXS-6302	Monoamine Oxidase	Others
PXS-6302 is an irreversible lysyl oxidase inhibitor with IC₅₀s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance.

HY-113056AS

N1-Acetylspermidine-d6 hydrochloride	Endogenous Metabolite	Cancer
N1-Acetylspermidine-d₆ (hydrochloride) is the deuterium labeled N1-Acetylspermidine hydrochloride. N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA[1][2][3].

HY-13653S

(+/-)-Epigallocatechin Gallate-13C3	Autophagy Reactive Oxygen Species HIV Ferroptosis Mitochondrial Metabolism Endogenous Metabolite	Cancer
(+/-)-Epigallocatechin Gallate-¹³C₃ is the ¹³C-labeled (-)-Epigallocatechin Gallate. (-)-Epigallocatechin Gallate is a tea flavonoid with potent antioxidant, antiinflammatory, and anticarcinogenic properties. (-)-Epigallocatechin Gallate is reported to inhibit EGFR signaling and thereby exert anticancer effects[1]. (-)-Epigallocatechin Gallate (EGCG) is a glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) inhibitor. Epigallocatechin-3-gallate induces oxidative phosphorylation (OXPHOS) by activating cytochrome c oxidase.

HY-17447AS

(1S,2R)-Tranylcypromine-d5 hydrochloride (1S,2R)-SKF 385-d₅ hydrochloride	Monoamine Oxidase	Neurological Disease
(1S,2R)-Tranylcypromine-d₅ (hydrochloride) is the deuterium labeled Tranylcypromine hydrochloride[1]. Tranylcypromine hydrochloride (SKF 385 hydrochloride) is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Tranylcypromine hydrochloride inhibits LSD1, MAO A and MAO B with IC50s of 20.7, 2.3 and 0.95 μM, respectively. Tranylcypromine hydrochloride can be used for the research of depression[2][3][4].

HY-D0958

Methylene blue hydrate Basic Blue 9 hydrate; CI-52015 hydrate; Methylthioninium chloride hydrate	Guanylate Cyclase Monoamine Oxidase NO Synthase Microtubule/Tubulin	Cancer Infection Inflammation/Immunology
Methylene blue (Basic Blue 9) hydrate is a guanylyl cyclase (sGC), *monoamine oxidase* A (MAO-A) and NO synthase (NOS)** inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue hydrate through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue hydrate is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue hydrate is a Tau aggregation inhibitor. Methylene blue hydrate reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation.

HY-151388

hMAO-B/MB-COMT-IN-1	Monoamine Oxidase COMT	Neurological Disease
hMAO-B/MB-COMT-IN-1 is a dual MAO-B/MB-COMT inhibitor (IC₅₀s: 2.5 μΜ for hMAO-B, 3.84 μΜ for MB-COMT). hMAO-B/MB-COMT-IN-1 protects cells against oxidative damage. hMAO-B/MB-COMT-IN-1 can be used in the research of neurodegeneration disease, such as Parkinson’s Disease (PD).

HY-147508

SBP-2	Fluorescent Dye	Others
SBP-2 is a sulfite bioluminescent probe (SBP). The recognition of SBP-2 towards sulfite is based on the mechanism of a sulfite-mediated intramolecular cleavage reaction.

HY-147509

SBP-3	Fluorescent Dye	Others
SBP-3 is a sulfite bioluminescent probe (SBP). The recognition of SBP-3 towards sulfite is based on the mechanism of a sulfite-mediated intramolecular cleavage reaction.

HY-151390

hMAO-B/MB-COMT-IN-2	Monoamine Oxidase COMT	Neurological Disease
hMAO-B/MB-COMT-IN-2 is a dual MAO-B/MB-COMT inhibitor (IC₅₀s: 4.27 μΜ for hMAO-B, 2.69 μΜ for MB-COMT). hMAO-B/MB-COMT-IN-2 protects cells against oxidative damage. hMAO-B/MB-COMT-IN-2 can be used in the research of neurodegeneration disease, such as Parkinson’s Disease (PD).

HY-14536

Methylene Blue Basic Blue 9; CI-52015; Methylthioninium chloride	Guanylate Cyclase Monoamine Oxidase NO Synthase Microtubule/Tubulin	Cancer Infection Neurological Disease
Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), *monoamine oxidase* A (MAO-A) and NO synthase (NOS)** inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation. Storage: protect from light.

HY-70057

Safinamide FCE 26743; EMD 1195686	Monoamine Oxidase	Neurological Disease
Safinamide is a potent, selective, and reversible *monoamine oxidase* B (MAO-B) inhibitor (IC₅₀=0.098 µM) over MAO-A (IC₅₀=580 µM). Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC₅₀=8 µM) than at resting (IC₅₀**=262 µM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al.

HY-147908

Adenosine receptor inhibitor 2	Adenosine Receptor	Inflammation/Immunology
Adenosine receptor inhibitor 2 (compound 14b) is a potent AR (adenosine receptor) inhibitor. Adenosine receptor inhibitor 2 shows dual affinity toward A₁/A_2A ARs with higher affinity for the A₁- than the A_2AAR. Adenosine receptor inhibitor 2 has K_i values of 52.2 nM for the A₁AR and 167 nM for the A_2AAR.

HY-144673

LSD1-IN-12	Histone Demethylase Monoamine Oxidase	Cancer
LSD1-IN-12 (compound 2) is a potent LSD1 inhibitor, with K_i values of 1.1 μM (LSD1), 61 μM (LSD2), 2.3 μM (MAO-A), and 3.5 μM (MAO-B), respectively.

HY-70057A

Safinamide mesylate FCE 26743 mesylate; EMD 1195686 mesylate	Monoamine Oxidase	Neurological Disease Cardiovascular Disease
Safinamide (FCE 26743; EMD 1195686) mesylate is a potent, selective, and reversible *monoamine oxidase* B (MAO-B) inhibitor (IC₅₀=0.098 µM) over MAO-A (IC₅₀=580 nM). Safinamide mesylate also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC₅₀=8 µM) than at resting (IC₅₀**=262 µM) potentials. Safinamide mesylate has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke et.al.

HY-101392S1

Harmane-d2	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor	Cancer Neurological Disease
Harmane-d₂ is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

HY-101392S

Harmane-d1	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor	Cancer Neurological Disease
Harmane-d is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

HY-151562

AChE/BuChE/MAO-B-IN-1	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
AChE/BuChE/MAO-B-IN-1 (compound 19) is an inhibitor of human acetyl- (hAChE), butyrylcholinesterase (hBuChE) and monoamine oxidase-B (hMAO-B) with IC₅₀s of 4.8 μM, 13.7 μM, and 1.11 μM, respectively. AChE/BuChE/MAO-B-IN-1 also exhibits high affinity to both the σ₁ and σ₂ receptors with K_i values of 42.8 nM (human σ₁ receptor) and 191 nM (rat σ₂ receptor), respectively. AChE/BuChE/MAO-B-IN-1 can be used for Alzheimer’s disease research.

HY-70057S1

Safinamide-d4-1 FCE 26743-d₄-1; EMD 1195686-d₄-1	Monoamine Oxidase	Neurological Disease
Safinamide-d₄-1 is deuterium labeled Safinamide. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 µM) over MAO-A (IC50=580 µM)[1]. Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8 µM) than at resting (IC50=262 µM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al[2][3].

HY-147507

SBP-1	Fluorescent Dye	Others
SBP-1 is a sulfite bioluminescent probe (SBP). SBP-1 exhibits the excellent responsivity, selectivity and sensitivity towards sulfite. The recognition of SBP-1 towards sulfite is based on the mechanism of a sulfite-mediated intramolecular cleavage reaction. SBP-1 can be used for detection of exogenous and endogenous sulfite in living animal. SBP-1 also possesses a capability for quantitatively detecting sulfite within a certain concentration range in solution.

HY-146313

BChE-IN-7	Cholinesterase (ChE)	Neurological Disease
BChE-IN-7 (compound 13) is a potent, selective, BBB-penetrated and reversible AChE and BChE inhibitor, with an IC₅₀ of 0.06 μM (BChE). BChE-IN-7 can protect neuronal-like cells from toxic Aβ-species.

HY-144758

LSD1-IN-17	Histone Demethylase Monoamine Oxidase	Cancer
LSD1-IN-17 (compound 5b) is a potent LSD1 inhibitor. LSD1-IN-17 can inhibit LSD1-CoREST, MAO-A and MAO-B, with IC₅₀ values of 0.005, 0.028, and 0.820 μM, respectively. LSD1-IN-17 displays cell growth arrest in prostate cancer LNCaP cells, with an IC₅₀ of 17.2 μM.

HY-144756

LSD1-IN-15	Histone Demethylase Monoamine Oxidase	Cancer
LSD1-IN-15 (compound 1b) is a potent LSD1 inhibitor. LSD1-IN-15 can inhibit LSD1-CoREST, MAO-A and MAO-B, with IC₅₀ values of 0.149, 0.028, and 0.327 μM, respectively. LSD1-IN-15 displays cell growth arrest in prostate cancer LNCaP cells, with an IC₅₀ of 9.9 μM.

HY-144757

LSD1-IN-16	Histone Demethylase Monoamine Oxidase	Cancer
LSD1-IN-16 (compound 4b) is a potent LSD1 inhibitor. LSD1-IN-16 can inhibit LSD1-CoREST, MAO-A and MAO-B, with IC₅₀ values of 0.015, 0.024, and 0.366 μM, respectively. LSD1-IN-16 displays cell growth arrest in prostate cancer LNCaP cells, with an IC₅₀ of 15.2 μM.

Cat. No.	Product Name

HY-L034

Anti-Aging Compound Library

3641 compounds

Aging is a complex biological process characterized by functional decline of tissues and organs, structural degeneration, and reduced adaptability and resistance, all of which contribute to an increase in morbidity and mortality caused by multiple chronic diseases, such as Alzheimer's disease, cancer, and diabetes. Many theories, which fall into two main categories: programmed and error theories, have been proposed to explain the process of aging, but neither of them appears to be fully satisfactory. The programmed theories imply that aging relies on specific gene regulation, and the error theories emphasize the internal and environmental damages accumulated to living organisms. The damage theories proposed the nine hallmarks that were generally considered to contribute to the aging process: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication.

MCE Anti-Aging Compound Library contains 3641 compounds, mainly targeting Sirtuin, mTOR, IGF-1R, AMPK, p53, Telomerase, Mitophagy, Mitochondrial Metabolism, COX, Cytochrome P450, Oxidase, etc. This library is a useful tool for anti-aging research.

HY-L085

Anti-Parkinson's Disease Compound Library

1111 compounds

Parkinson’s disease (PD), the second most common age-associated neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and the presence of α-synuclein-containing aggregates in the substantia nigra pars compacta (SNpc). Motor features such as tremor, rigidity, bradykinesia and postural instability are common traits of PD. To date, there is no treatment to stop or at least slow down the progression of the disease. The etiology and pathogenesis of PD is still elusive, however, a large body of evidence suggests a prominent role of oxidative stress, inflammation, apoptosis, mitochondrial dysfunction and proteasome dysfunction in the pathogenesis of PD.

MCE offers a unique collection of 1111 compounds with anti- Parkinson’s Disease activities or targeting the unique targets of PD. MCE Anti- Parkinson's Disease Compound Library is a useful tool for exploring the mechanism of PD and discovering new drugs for PD.

HY-L086

Neurodegenerative Disease-related Compound Library

1839 compounds

Neurodegenerative diseases are incurable and life-threatening conditions that result in progressive degeneration and/or death of nerve cells. Some common neurodegenerative diseases include Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Motor Neuron Disease (MND), Huntington’s Disease (HD), Spino-Cerebellar Ataxia (SCA), Spinal Muscular Atrophy (SMA), and Amyotrophic Lateral Sclerosis (ALS). Because the pathophysiology of neurodegenerative disorders is generally poorly understood, it is difficult to identify promising molecular targets and validate them. At the same time, about 85% of the drugs fail in clinical trials. Therefore, validating new targets and discovering new drugs to mitigate neurodegenerative disorders is need of the hour.

MCE offers a unique collection of 1839 compounds with anti-Neurodegenerative Diseases activities or targeting the unique targets of neurodegenerative diseases. MCE Neurodegenerative Disease-related Compound Library is a useful tool for exploring the mechanism of neurodegenerative diseases and discovering new drugs for neurodegenerative diseases.

Cat. No.	Product Name	Type

HY-D0004

Azure B Azure B chloride	Dyes
Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of *monoamine oxidases* (MAO)-A, with IC₅₀**s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects.

HY-14536

Methylene Blue

Basic Blue 9; CI-52015; Methylthioninium chloride

Chromogenic Assays

Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation. Storage: protect from light.

Cat. No.	Product Name	Type

HY-P2742

Ascorbate oxidase ASO	Enzyme
Ascorbate oxidase, also known as vitamin C oxidase, is a REDOX enzyme involved in the regulation of extracellular matrix. Ascorbate oxidase catalyzes the reaction of ascorbic acid and oxygen to produce dehydroascorbic acid.

HY-P2891

Pyruvate oxidase PoxB	Enzyme
Pyruvate oxidase (PoxB) is a thiamine pyrophosphate-dependent oxidase that catalyzes the oxidative decarboxylation of pyruvate to acetyl phosphate, carbon dioxide and water. Pyruvate oxidase is an important enzyme in bacterial metabolism and is often used in biochemical research.

HY-134757

Lactate oxidase	Enzyme
Lactate oxidase belongs to a group of FMN-dependent enzymes and they catalyze a conversion of lactate to pyruvate with a release of hydrogen peroxide. Lactate oxidase can be used in the detection of Lactate.

HY-P2888

Bilirubin oxidase BOD	Enzyme
Bilirubin oxidase (BOD) is a multi-copper oxidase that catalyzes the oxidation of bilirubin to biliverdin and reduces molecular oxygen to water. Bilirubin oxidase can participate in the metabolism of porphyrin and chlorophyll, and is widely used in biochemical research as a catalyst for oxygen reduction.

HY-P2910

Galactose oxidase GOase	Enzyme
Galactose oxidase (GOase) from fungus is often used in biochemical studies. Galactose oxidase is a type II copper metalloenzyme, and it containing a single polypeptide. Galactose oxidase catalyzes two-electron oxidation of primary alcohols to their corresponding aldehydes, coupling with the reduction of dioxygen to hydrogen peroxide.

HY-P2733

Glycerol-3-phosphate oxidase GPO	Enzyme
Glycerol-3-phosphate oxidase is a key intermediate in glycerol metabolism. Glycerol-3-phosphate oxidase can be extracted from Escherichia coli. Glycerol-3-phosphate oxidase is the skeleton of phospholipids in membrane lipids, and also the substrate of respiratory chain. Glycerol-3-phosphate oxidase produces electrons through oxidation.

HY-P2921

Urate oxidase Uox	Enzyme
Urate oxidase (Uox), i.e., uricase, is often used in biochemical studies. Urate oxidase is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most mammals.

HY-P2986

D-Amino acid oxidase	Enzyme
D-Amino acid oxidase is an enzyme to metabolize exogenous D-amino acids in animals for detoxifying action. D-Amino acid oxidase also modulates the level of D-serine in brain.

HY-P2848

Cholesterol oxidase ChOx	Enzyme
Cholesterol oxidase (ChOx) is a bacterial flavin oxidase containing FAD, commonly used in biochemical research. Cholesterol oxidase catalyzes the oxidation of the C(3)-OH group of cholesterol (and other sterols) to cholest-5-en-3-one and isomerizes it to cholest-4-en-3-one.

HY-P2987

L-Amino acid oxidase	Enzyme
L-Amino acid oxidase is a homodimeric proteins containing flavin adenine dinucleotide. L-Amino acid oxidase can catalyze the stereospecific oxidative deamination of L-amino acids to α-keto acids and ammonia.

HY-E70074

Monoamine oxidase	Enzyme
Monoamine oxidase is an enzyme composed of different polypeptides. Monoamine oxidation catalyzes the oxidative deamination of various biological amines in brain and peripheral tissues by producing hydrogen peroxide. Monoamine oxidase plays an important role in maintaining the regulation of synaptic transmission, emotional behavior and other brain functions.

HY-P2902

Glucose oxidase	Enzyme
Glucose oxidase is used in the food and beverage industry as a preservative and stabilizer and is commonly derived from the fungus Aspergillus niger. Glucose oxidase can react with intracellular glucose and oxygen (O₂) to produce hydrogen peroxide (H₂O₂) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation.

HY-P2755

Xanthine oxidase	Enzyme
Xanthine oxidase is a xanthine oxidoreductase enzyme that generates reactive oxygen species (ROS), catalyzes the oxidation of hypoxanthine to xanthine, and further catalyzes the oxidation of xanthine to uric acid.

HY-P2756

Alcohol oxidase
AO; AOX
Enzyme

Alcohol oxidase is a functional enzyme of methanol utilization pathway and can be isolated from yeast peroxisome.

HY-125860

Tyrosinase Polyphenol oxidase	Enzyme
Tyrosinase (Polyphenol oxidase) is a rate-limiting enzyme that controls the production of melanin and is encoded by TYR gene. Tyrosinase is mainly found in melanosomes synthesized by skin melanocytes.

HY-E70082

Fructosyl amino acid oxidase	Enzyme
Fructosyl amino acid oxidase can be used to measure glycosylated protein. Glycosylated protein, especially glycosylated hemoglobin A1c, is an important marker to evaluate the efficacy of diabetes treatment.

HY-P2861

Sarcosine oxidase SAO	Enzyme
Sarcosine oxidase (SAO) can catalyze the oxidative demethylation of sarcosine to generate glycine, H₂O₂, 5,10-CH₂-tetrahydrofolate, which are often used in biochemical reactions.

HY-E70009

Acyl-CoA oxidase ACO	Enzyme
Acyl-CoA oxidase (ACO) catalyses the first and rate-determining step of the peroxisomal beta-oxidation of fatty acids and a major producer of hydrogen peroxide (H₂O₂).

HY-W288940

3,3-Diaminobenzidine tetrahydrochloride dihydrate	Biochemical Assay Reagents
3,3-Diaminobenzidine tetrahydrochloride dehydrate is a staining agent that is often used in histochemical (HC) and immunohistochemical (IHC) procedures. 3,3-Diaminobenzidine tetrahydrochloride dehydrate can be used for peroxisomal staining and mitochondrial cytochrome c oxidase activity staining.

HY-15929

TBHBA 2,4,6-Tribromo-3-hydroxybenzoic acid	Biochemical Assay Reagents
The Boehringer Mannheim cholesterol esterase/cholesterol oxidase/peroxidase/3,4-dichlorophenol kinetic reagent was modified by the inclusion of TBHBA (2,4,6-Tribromo-3-hydroxybenzoic acid) which reacts with hydrogen peroxide and 4-aminophenazone to produce a quinone-imine dye with a greater molar absorptivity than that produced with phenol.

HY-P2890

Laccase Denilite IIS	Enzyme
Laccase (Denilite IIS) is a multi-copper oxidase (MCOs), which widely exists in microorganisms, plants and fungi, and can catalyze the oxidation of one electron of various phenolic compounds. Laccase can promote the oxidative coupling of single lignin, which plays an important role in the formation and biodegradation of lignin, and also has the potential to cross-link food polymers.

HY-125863

Glucose-6-phosphate dehydrogenase

Enzyme

Glucose-6-phosphate dehydrogenase is the rate-limiting enzyme of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase is a major source of NADPH that is required by many essential cellular systems including the antioxidant pathways, nitric oxide synthase, NADPH oxidase, cytochrome p450 system, and others. Glucose-6-phosphate dehydrogenase can be used for the research of diabetes, aldosterone-induced endothelial dysfunction, and cancer.

Cat. No.	Product Name	Target	Research Area

HY-P2888

Bilirubin oxidase BOD	Endogenous Metabolite	Metabolic Disease
Bilirubin oxidase (BOD) is a multi-copper oxidase that catalyzes the oxidation of bilirubin to biliverdin and reduces molecular oxygen to water. Bilirubin oxidase can participate in the metabolism of porphyrin and chlorophyll, and is widely used in biochemical research as a catalyst for oxygen reduction.

HY-P2743

Choline oxidase	Biochemical Assay Reagents	Others
Choline oxidase catalyzes the oxidation of choline to glycine betaine via betaine aldehyde in glycine betaine biosynthesis and betaine acts as an osmolyte. Choline oxidase has potential in enzymatic betaine production.

HY-P1120

WKYMVM	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
WKYMVM is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase.

HY-P1120A

WKYMVM TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
WKYMVM (TFA) is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase.

HY-P1121A

WKYMVM-NH2 TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase.

HY-W011258

H-Tyr-Phe-OH L-Tyrosyl-L-phenylalanine	Xanthine Oxidase Angiotensin-converting Enzyme (ACE)	Cancer Inflammation/Immunology
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells.

HY-P1908

sgp91 ds-tat Peptide 2, scrambled
Peptides Cancer Cardiovascular Disease

sgp91 ds-tat Peptide 2, scrambled is a scrambled sequence of NADPH oxidase inhibitor gp91 ds-tat peptide.

HY-P1118

Ac9-25	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Ac9-25, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR.

HY-P1118A

Ac9-25 TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Ac9-25 TFA, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR.

HY-P1435A

NoxA1ds TFA	NADPH Oxidase
NoxA1ds TFA is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC₅₀=20 nM). NoxA1ds TFA exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. NoxA1ds TFA inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.

HY-P1435

NoxA1ds	NADPH Oxidase	Cardiovascular Disease
NoxA1ds is a highly efficacious and selective Nox1 (NADPH oxidase isoform 1) inhibitor. NoxA1ds establishes a critical interaction site for Nox1-NOXA1 binding required for enzyme activation. NoxA1ds can be used for the research of hypertension, atherosclerosis and neoplasia.

Cat. No.	Product Name	Target	Research Area

HY-P99047

Simtuzumab AB 0024; GS 6624	Monoamine Oxidase	Inflammation/Immunology
Simtuzumab (AB 0024; GS 6624) is a monoclonal antibody directed against Lysyl oxidase like-2 (LOXL2). Simtuzumab can be used for the research of primary sclerosing cholangitis (PSC).

Cat. No.	Product Name	Target	Category

HY-N10432

*Xanthine oxidase-IN-8* Icarisids J	Xanthine Oxidase	Flavonoids Flavonols Source classification Plants Juglandaceae Cyclocarya paliurus (Batal.) Iljinsk.
Xanthine oxidase-IN-8 (Icarisids J) (Compound 7) is a XOD inhibitor with an IC₅₀ of 29.71 μM.

HY-N10433

*Xanthine oxidase-IN-9* Icarisids E	Xanthine Oxidase	Flavonoids Source classification Plants Juglandaceae Cyclocarya paliurus (Batal.) Iljinsk.
Xanthine oxidase-IN-9 (Icarisids E) (Compound 2) is a potent *xanthine oxidase* (XOD) inhibitor with an IC₅₀** of 31.81 μM.

HY-N7397

Forsythoside F Arenarioside	Xanthine Oxidase	Phenylpropanoids Simple Phenylpropanols Phenols Polyphenols Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Plants Oleaceae Forsythia suspensa (Thunb.) Vahl
Forsythoside F (Arenarioside) is a xanthine oxidase inhibitor and possesses antihyperuricemic effects in vivo.

HY-W041301

(±)-Dihydroactinidiolide	Others	Natural Products Other Diseases Disease Research Fields Classification of Application Fields Source classification Plants Solanaceae Nicotiana tabacum L.
(±)-Dihydroactinidiolide, an important aroma compound of black tea and tobacco, has been isolated from several plants. (±)-Dihydroactinidiolide can be formation from β-Carotene by the treatment of polyphenoloxidase, the lipoxygenase, and the xanthine oxidase.

HY-N10741

Ellagic acid 4-O-β-D-xylopyranoside	Xanthine Oxidase Bacterial	Structural Classification Natural Products Source classification Plants Cunoniaceae Cunonia macrophylla Brongn. & Gris
Ellagic acid 4-O-β-D-xylopyranoside is a natural ellagitannin with antimicrobial activity. Ellagic acid 4-O-β-D-xylopyranoside is an xanthine oxidase inhibitor with an ₅₀ of 2.1 μg/mL.

HY-N9608

6-Ketocholestanol 3β-Hydroxy-5α-cholestan-6-one	Others	Steroids Source classification Plants Apocynaceae Diospyros virginiana L.
6-Ketocholestanol is a recoupler for mitochondria, chromatophores and cytochrome oxidase proteoliposomes. 6-Ketocholestanol increases the membrane dipole potential.

HY-N9329

Glicoricone	Monoamine Oxidase Estrogen Receptor/ERR	Flavonoids Isoflavones Phenols Polyphenols Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Plants Leguminosae Glycyrrhiza uralensis Fisch.
Glicoricone, a phenolic compound, is isolated from a species of licorice. Glicoricone is an inhibitor of *monoamine oxidase* (MAO), with an IC₅₀ of 140 μM. Glicoricone binds to estrogen receptor (ER)** and shows estrogen antagonist activity.

HY-N9540

Methyl citrate	Monoamine Oxidase	Ketones, Aldehydes, Acids Source classification Plants Cactaceae Opuntia ficus-indica (L.) Mill.
Methyl citrate is a Monoamine oxidase B (MAO-B) inhibitor (IC₅₀=0.23 mM). Methyl citrate is isolated from the fruits of Opuntia ficus-indica var. saboten Makino.

HY-N1162

Tetrahydroamentoflavone Amentoflavanone	Xanthine Oxidase	Structural Classification Biflavones Flavonoids Semecarpus anacardium L.f. Anacardiaceae Plants Source classification
Tetrahydroamentoflavone (Amentoflavanone) is a potent *xanthine oxidase* (XO) inhibitor. Tetrahydroamentoflavone has inhibitory activity for XO with IC₅₀ and K_i** values of 92 nM and 0.982 μM, respectively. Tetrahydroamentoflavone can be used for the research of inflammatory disorders and gout.

HY-129137

Cyanidin 3-sophoroside chloride Cy 3-soph	Others	Plants Rosaceae Prunus cerasus L.
Cyanidin 3-sophoroside chloride is a potent non-competitive reversible polyphenol oxidase (PPO) inhibitor. Also, Cyanidin 3-sophoroside chloride can be used as an anti-browning agent to inhibit the degree of PPO browning, enhance the antioxidant damage capacity of fruits and prolong the storage period.

HY-N0327

Lobetyolin	Apoptosis Xanthine Oxidase	Natural Products Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Plants Campanulaceae Codonopsis pilosula
Lobetyolin, a bioactive compound, is derived from Codonopsis pilosula. Lobetyolin has anti-inflammatory, anti-oxidative and xanthine oxidase inhibiting activities. Lobetyolin also induces the apoptosis via the inhibition of ASCT2-mediated glutamine metabolism.

HY-Y1750

β-Aminopropionitrile BAPN	Monoamine Oxidase Endogenous Metabolite	Natural Products Classification of Application Fields Disease Research Fields Cancer Source classification Endogenous metabolite
β-Aminopropionitrile (BAPN) is a specific, irreversible and orally active *lysyl oxidase* (LOX)** inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes.

HY-W014502

D-Kynurenine	Aryl Hydrocarbon Receptor Endogenous Metabolite	Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Cancer Source classification Endogenous metabolite
D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR).

HY-N1636

1-Methyl-2-nonyl-4(1H)-quinolone	Monoamine Oxidase	Alkaloids Quinoline Alkaloids Classification of Application Fields Disease Research Fields Neurological Disease Source classification Plants Rutaceae
1-Methyl-2-nonyl-4(1H)-quinolone, a quinolone alkaloid, is a potent and selective MAO-B (monoamine oxidase) inhibitor. 1-Methyl-2-nonyl-4(1H)-quinolone exhibites inhibitory activity on leukotriene biosynthesis, with an IC₅₀ of 12.1 μM.

HY-W018555

D-Cysteine	Endogenous Metabolite Bacterial	Amino acids Source classification Endogenous metabolite
D-Cysteine is the D-isomer of cysteine and a powerful inhibitor of *Escherichia coli* growth. D-cysteine is mediated by D-amino acid oxidase to produce H₂S and is a neuroprotectant against cerebellar ataxias. D-Cysteine could inhibit the growth and cariogenic virulence of dual-species biofilms formed by *S. mutans* and *S. sanguinis*.

HY-W008566

Norharmane Norharman; β-Carboline	Monoamine Oxidase Endogenous Metabolite	Alkaloids Pyridine Alkaloids Indole Alkaloids Source classification Microorganisms Endogenous metabolite
Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC₅₀ values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings.

HY-N1638

1-Methyl-2-undecyl-4(1H)-quinolone	Monoamine Oxidase	Alkaloids Quinoline Alkaloids Source classification Plants Rutaceae Evodia rutaecarpa (Juss.) Benth.
1-Methyl-2-undecyl-4(1H)-quinolone is a potent, irreversible and selective inhibitor of type B monoamine oxidase (MAO-B). 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of MAO-B activity with the IC₅₀ and K_i values of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity. Methyl-2-undecyl-4(1H)-quinolone, as a quinolone alkaloid, is isolated from fresh leaves and fruits of Evodia rutaecarpa HOOK. f. et THOMS.

HY-101392

Harmane	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor	Alkaloids Pyridine Alkaloids Indole Alkaloids Source classification Plants other families
Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of *monoamine oxidase* (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B**, respectively). Harmane exhibits comutagenic effect.

HY-N0088

Apocynin Acetovanillone	Autophagy Apoptosis	Ketones, Aldehydes, Acids Monophenols Phenols Disease Research Fields Cancer Classification of Application Fields Source classification Plants Orchidaceae Anoectochilus roxburghii (Wall.) Lindl.
Apocynin is a selective *NADPH-oxidase* inhibitor with an IC₅₀ of 10 μM.

HY-N9330

Broussoflavonol F	Xanthine Oxidase	Flavonoids Flavonols Phenols Polyphenols Classification of Application Fields Disease Research Fields Other Diseases Source classification Plants other families
Broussoflavonol F possess xanthine oxidase inhibitory activity.

HY-Y0127

D(-)-2-Aminobutyric acid	Endogenous Metabolite	Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Other Diseases Source classification Endogenous metabolite
D(-)-2-Aminobutyric acid is a substrate of D-amino acid oxidase.

HY-111588

Xanthoangelol	Apoptosis Monoamine Oxidase Bacterial AMPK	Chalcones Phenols Polyphenols Structural Classification Flavonoids Umbelliferae Angelica keiskei Plants Source classification Inflammation/Immunology Infection Disease Research Fields Classification of Application Fields
Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses. Xanthoangelol possesses antibacterial activity. Xanthoangelol inhibits monoamine oxidases. Xanthoangelol induces apoptosis in neuroblastoma and leukemia cells.

HY-22385A

Salsolidine hydrochloride	Monoamine Oxidase	Alkaloids Isoquinoline Alkaloids Source classification Plants other families
Salsolidine hydrochloride, a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive *MAO A (monoamine oxidase* A)** inhibitor.

HY-N0196

Baicalein 5,6,7-Trihydroxyflavone	Xanthine Oxidase Influenza Virus Ferroptosis	Phenols Polyphenols Flavones Flavonoids Disease Research Fields Cancer Anti-aging Classification of Application Fields Source classification Plants Labiatae Scutellaria baicalensis Georgi
Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC₅₀ value of 3.12 μM.

HY-N3906

Fraxamoside	Xanthine Oxidase	Structural Classification Phenols Polyphenols Oleaceae Fraxinus americana L. Plants Source classification
Fraxamoside is a competitive xanthine oxidase inhibitor with an IC₅₀ of 16.1 μM and a K_i of 0.9 μM.

HY-I0637

Isovanillin 3-Hydroxy-4-methoxybenzaldehyde	Others	Phenols Monophenols Ketones, Aldehydes, Acids Source classification Plants Asclepiadaceae Periploca sepium Bunge
Isovanillin is an aldehyde oxidase inhibitor. Antispasmodic activities. Antidiarrheal activities.

HY-19657

Oxypurinol Oxipurinol	Endogenous Metabolite Xanthine Oxidase	Natural Products Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Endogenous metabolite
Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout.

HY-N1547

Prudomestin	Xanthine Oxidase	Structural Classification Flavonols Phenols Polyphenols Flavonoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Rosaceae Prunus domestica L.
Prudomestin, isolated from the heartwood of Prunus domestica, shows potent *xanthine oxidase* (XO)** inhibitory activity (IC₅₀≈6 µM).

HY-N7603

Rubrofusarin triglucoside	Monoamine Oxidase	Phenols Monophenols Ketones, Aldehydes, Acids Source classification Plants Leguminosae seeds of Cassia tora Linn. other families
Rubrofusarin triglucoside is a glycoside compound isolated from Cassia obtusifolia Linn seeds. Rubrofusarin triglucoside inhibits *human monoamine oxidase* A (hMAO-A) with an IC₅₀** of 85.5 μM.

HY-22385B

(S)-Salsolidine	Monoamine Oxidase Endogenous Metabolite	Alkaloids Isoquinoline Alkaloids Source classification Plants Chenopodiaceae Salsola
(S)-Salsolidine is a weak *monoamine oxidase* (MAO) inhibitor (K_i**=63 μM). The R enantiomer of Salsolidine is more potent than the S form (K_i=26 μM).

HY-N9324

Ilexoside O	Xanthine Oxidase	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Aquifoliaceae Ilex pubescens Hook. et Arn.
Ilexoside O is a triterpene saponin isolated from the roots of Ilex pubescens. Ilexoside O exhibits weak *xanthine oxidase* (XOD)** inhibitory activity (IC₅₀=53.05 μM).

HY-N10863

Aurantiamide benzoate	Xanthine Oxidase	Structural Classification Alkaloids Pyridine Alkaloids Celastrus rugosus Rehd. et Wils. Celastraceae Plants Source classification
Aurantiamide benzoate is a nature product that could be isolated from two tropical medicinal plants, Cunila spicata and Hyptis fasciculata. Aurantiamide benzoate is a potent xanthine oxidase inhiobitor with an IC₅₀ value of 70 μM.

HY-12136

Purpurogallin	Xanthine Oxidase	Structural Classification Phenols Polyphenols Quercus Plants Fagaceae Inflammation/Immunology Disease Research Fields Cancer
Purpurogallin is a naturally phenol extracted from the plants of Quercus spp, has potent *xanthine oxidase* (XO) inhibitory activity with an IC₅₀** of 0.2 µM. Purpurogallin has antioxidant and anti-inflammatory effects.

HY-N0699

Daphnoretin Dephnoretin; Thymelol	PKC Influenza Virus	Coumarins Phenylpropanoids Monophenols Phenols Infection Disease Research Fields Classification of Application Fields Source classification Plants Thymelaeaceae Wikstroemia indica
Daphnoretin (Dephnoretin), isolated from Wikstroemia indica, possesses antiviral activity. Daphnoretin likes PMA, may direct activation of protein kinase C which in turn activated NADPH oxidase and elicited respiratory burst.

HY-N2510

Myristicin Myristicine	5-HT Receptor	Phenylpropanoids Simple Phenylpropanols Source classification Plants Myristicaceae Myristica fragrans Houtt.
Myristicine act as a serotonin receptor antagonist, a weak *monamine oxidase* (MAO)** inhibitor. Myristicine is the main component of nutmeg essential oil from Myristica fragrans Houtt. Myristicine abuse produce hallucinogenic effects, organ damage, deliriumand others.

HY-N3220

Myricetin 3-O-galactoside	Xanthine Oxidase	Flavonoids Flavonols Phenols Polyphenols Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Plants Ericaceae Rhododendron dauricum Linn.
Myricetin 3-O-galactoside inhibits *xanthine oxidase* (XO)** activity, lipid peroxidation and scavenges the free radical. Myricetin 3-O-galactoside inhibits lipid peroxidation with an IC₅₀ of 160 μg/mL. Antioxidant activity.

HY-N6057

Obtusin	Monoamine Oxidase	Quinones Anthraquinones Phenols Polyphenols Source classification Plants Leguminosae seeds of Cassia tora Linn. other families
Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive *human monoamine oxidase-A (hMAO-A)* inhibitor with an IC₅₀ of 11.12 μM and a K_i of 6.15 μM. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression.

HY-N8200

Cassiaside B2	Phosphatase Monoamine Oxidase 5-HT Receptor	Phenols Monophenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Caesalpiniaceae Cassia obtusifolia L.
Cassiaside B2 is a protein tyrosine phosphatase 1B (PTP1B) and *human monoamine oxidase* A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a 5-HT2C** receptor agonist...

HY-N2472

Medicagenic acid Castanogenin	Bacterial	Triterpenes Terpenoids Structural Classification Caryophyllaceae Herniaria glabra Linnaeus. Plants Infection Disease Research Fields Classification of Application Fields
Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes. Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE.

HY-N4037

Homopterocarpin (-)-Homopterocarpin; 3,9-Dimethoxypterocarpan	Monoamine Oxidase	Structural Classification Terpenoids Other Terpenoids Pterocarpus indicus willd. Leguminosae Plants Source classification
Homopterocarpin is an isoflavonoid that can be isolated from Pterocarpus erinaceus. Homopterocarpin has hepatoprotective and antioxidant properties. Homopterocarpin is a competitive reversible inhibitor of human monoamine *oxidase-B* with an IC₅₀ and a K_i of 0.72 and 0.21 μM for hMAO-B, respectively. Homopterocarpin can be used for the research of liver injury and oxidative stress.

HY-N7204

4-Hydroxyderricin	Monoamine Oxidase Dopamine β-hydroxylase	Chalcones Structural Classification Monophenols Phenols Flavonoids Umbelliferae Angelica keiskei Plants
4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is a potent selective *MAO-B (Monoamine oxidase* inhibitors) inhibitor with an IC₅₀ of 3.43 μM. 4-Hydroxyderricin also mildly inhibits DBH (dopamine β-hydroxylase)** activity. 4-Hydroxyderricin has antidepressant activity.

HY-N0814B

Phytic acid hexasodium Inositol hexaphosphate hexasodium	Endogenous Metabolite	Ketones, Aldehydes, Acids Structural Classification other families Plants Source classification
Phytic acid (Inositol hexaphosphate) hexasodium is a phosphorus storage compound of seeds and cereal grains. Phytic acid hexasodium has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid hexasodium inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.

HY-N2554

Osthenol Ostenol	Monoamine Oxidase	Phenylpropanoids Coumarins Phenols Polyphenols Source classification Plants Umbelliferae Notopterygium incisum Ting ex H. T. Chang
Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (K_i=0.26 µM). Osthenol potently inhibits recombinant hMAO-A with an IC₅₀ of 0.74 µM and shows a high selectivity index for hMAO-A versus hMAO-B.

HY-N0814

Phytic acid Inositol hexaphosphate	Xanthine Oxidase Endogenous Metabolite	Ketones, Aldehydes, Acids Inflammation/Immunology Neurological Disease Disease Research Fields Agricultural Research Classification of Application Fields Food Preservation Research Source classification Plants other families Endogenous metabolite
Phytic acid (Inositol hexaphosphate) is a phosphorus storage compound of seeds and cereal grains. Phytic acid is known as a food inhibitor, which has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.

HY-142125

Broussochalcone A	Xanthine Oxidase Reactive Oxygen Species Apoptosis	Chalcones Structural Classification Flavonoids Plants Broussonetia papyrifera (Linnaeus) L'Heritier ex Ventenat Source classification Moraceae
Broussochalcone A is an antioxidant and an inhibitor of Xanthine Oxidase (IC₅₀=2.21 μM), with free radical scavenging activity. Broussochalcone A inhibits iron-induced lipid peroxidation and nitric oxide synthesis in lipopolysaccharide (LPS) -activated macrophages. Broussochalcone A also induces Apoptosis of human renal carcinoma cells by increasing ROS levels and activating FOXO3 signaling pathways.

HY-N0814A

Phytic acid dodecasodium hydrate Inositol hexaphosphate dodecasodium hydrate	Xanthine Oxidase Endogenous Metabolite	Ketones, Aldehydes, Acids Structural Classification other families Endogenous metabolite Plants Source classification
Phytic acid (Inositol hexaphosphate) dodecasodium hydrate is a phosphorus storage compound of seeds and cereal grains. Phytic acid dodecasodium hydrate is known as a food inhibitor, which has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid dodecasodium hydrate inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.

HY-Y0265

Isatin Indoline-2,3-dione	Monoamine Oxidase Apoptosis	Alkaloids Indole Alkaloids Classification of Application Fields Disease Research Fields Cardiovascular Disease Neurological Disease Source classification Plants other families
Isatin (Indoline-2,3-dione) is a potent inhibitor of *monoamine oxidase* (MAO) with an IC₅₀ of 3 μM. Also binds to central benzodiazepine receptors (IC₅₀ against clonazepam, 123 μM). Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase** activity. Shows effect on the serotonergic system.

HY-141508

Flazin	Xanthine Oxidase NO Synthase	Indole Alkaloids Source classification Plants Simaroubaceae Brucea javanica (L.) Merr.
Flazin is a non-enzymatic protein glycation inhibitor, also inhibits peroxynitrite (ONOO^-), with an IC₅₀ value of 85.31 μM for bovine serum albumin (BSA) glycation and an EC₅₀ value of 71.99 μM for ONOO^-. Flazin can be used for researching diabetes and neuronal disorders. Flazin also can used as a lipid droplet (LD) regulator against lipid disorders, and a *xanthine oxidase* (XOD)** inhibitor.

HY-N6947

Lutein Xanthophyll	Endogenous Metabolite Apoptosis Reactive Oxygen Species	Structural Classification Terpenoids Diterpenoids Inflammation/Immunology Disease Research Fields Classification of Application Fields
Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health. Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS). Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active.

Species:	Human (18) Mouse (4) Rat (1)
Tag:	His (22) SUMO (3) Tag Free (1) Trx (1)
Source:	HEK293 (6) CHO (1) Sf9 insect cells (2) E. coli (14)

Cat. No.	Product Name	Species	Source

HY-P71655

Hydroxyacid oxidase 1 Protein, Mouse (His)
Hao1; Gox1; Hao-1; Hydroxyacid oxidase 1; HAOX1; EC 1.1.3.15; Glycolate oxidase; GOX
Mouse E. coli

HY-P7898

*D-amino-acid oxidase/DAO Protein, Human (His)* rHuD-amino-acid oxidase/DAO, His; D-Amino-Acid oxidase; DAAO; DAMOX; DAO	Human	E. coli
D-amino-acid oxidase Protein, Human (His) is a recombinant D-amino-acid oxidase protein with a His tag. D-amino acid oxidase (DAO) is a flavin adenine dinucleotide (FAD)-dependent oxidase metabolizing neutral and polar D-amino acids.

HY-P71706

LOX Protein, Human (His)
lox; LYOX; Lysyl oxidase; MGC105112; Protein lysine 6 oxidase; Protein-lysine 6-oxidase
Human E. coli
HY-P70932

HAO1 Protein, Human (Trx-His)
Hydroxyacid oxidase 1; HAOX1; Glycolate oxidase; GOX; HAO1; GOX1; HAOX1
Human E. coli
HY-P71606

Lysyl oxidase homolog 4 Protein, Mouse (His)
Loxl4; Loxc; Lysyl oxidase homolog 4; EC 1.4.3.-; Lysyl oxidase-like protein 4; Lysyl oxidase-related protein C
Mouse E. coli

HY-P70065

AOC3 Protein, Human (HEK293, His) rHuMembrane primary amine oxidase/AOC3, His; Membrane primary amine oxidase; Copper amine oxidase; HPAO; Semicarbazide-sensitive amine oxidase; SSAO; Vascular adhesion protein 1; VAP-1; AOC3; VAP1	Human	HEK293

HY-P75541

ACOX1 Protein, Human (sf9, His)
Peroxisomal acyl-coenzyme A oxidase 1; AOX; SCOX; ACOX1
Human Sf9 insect cells
HY-P74771

LOXL2 Protein, Human (CHO, His)
Lysyl oxidase homolog 2; Lysyl oxidase-related protein WS9-14; LOXL2
Human CHO
HY-P74769

LOXL2 Protein, Mouse (HEK293, His)
Lysyl oxidase homolog 2; Lysyl oxidase-related protein WS9-14; LOXL2
Mouse HEK293
HY-P74770

LOXL2 Protein, Human (HEK293, His)
Lysyl oxidase homolog 2; Lysyl oxidase-related protein WS9-14; LOXL2
Human HEK293
HY-P76544

PHYH Protein, Human
Phytanoyl-CoA dioxygenase, peroxisomal; Phytanic acid oxidase; PhyH; PAHX
Human E. coli
HY-P74126

GFER Protein, Human (HEK293, His)
FAD-linked sulfhydryl oxidase ALR; hERV1; Hepatopoietin; ALR
Human HEK293

HY-P72150

COX4I1 Protein, Human (His-SUMO) AL024441; COX 4; COX IV 1; COX IV; COX IV-1; Cox4; COX41_HUMAN; Cox4a; COX4B; COX4I1; COX4I2; COX4L2; COXIV; Cytochrome c oxidase polypeptide IV; Cytochrome c oxidase subunit 4 isoform 1 mitochondrial; Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; Cytochrome C oxidase subunit IV; Cytochrome c oxidase subunit IV isoform 1; Cytochrome c oxidase subunit IV isoform 2 lung; ; Cytochrome c oxydase subunit 4; dJ857M17.2; MGC105470; MGC72016	Human	E. coli

HY-P75686

COX5B Protein, Human (His)
Cytochrome c oxidase subunit 5B, mitochondrial; COX5B
Human E. coli
HY-P71521

Rnls Protein, Mouse (His-SUMO)
Rnls; Renalase; EC 1.6.3.5; Monoamine oxidase-C; MAO-C; mMAO-C
Mouse E. coli
HY-P71571

GFER Protein, Rat (His-SUMO)
Gfer; AlrFAD-linked sulfhydryl oxidase ALR; EC 1.8.3.2; Augmenter of liver regeneration
Rat E. coli
HY-P73567

TRP1 Protein, Human (sf9, His)
5,6-dihydroxyindole-2-carboxylic acid oxidase; Catalase B; TRP-1; TYRP1; CAS2
Human Sf9 insect cells
HY-P73568

TRP1 Protein, Human (HEK293, His)
5,6-dihydroxyindole-2-carboxylic acid oxidase; Catalase B; TRP-1; TYRP1; CAS2
Human HEK293
HY-P76707

ABP1/AOC1 Protein, Human (751a.a, HEK293, His)
Amiloride-sensitive amine oxidase [copper-containing]; DAO; Histaminase; KAO
Human HEK293
HY-P70953

GFER Protein, Human (His)
FAD-linked sulfhydryl oxidase ALR; GFER; Augmenter of liver regeneration; hERV1; Hepatopoietin; GFER; ALR; HERV1; HPO
Human E. coli

HY-P70024

HPD/HPPDase Protein, Human (His) rHu4-hydroxyphenylpyruvate dioxygenase /HPD, His; 4-Hydroxyphenylpyruvate Dioxygenase; 4-Hydroxyphenylpyruvic Acid oxidase; 4HPPD; HPD; HPPDase; HPD; PPD	Human	E. coli

HY-P70290

Neutrophil cytosol factor 1 Protein, Human (His) rHuNeutrophil cytosol factor 1/NCF1, His; NCF-1; 47 kDa autosomal chronic granulomatous disease protein/47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2/SH3 and PX domain-containing protein 1A; p47-phox	Human	E. coli

HY-P72161

CYBB/Nox2 Protein, Human (His) AMCBX2; CGD; CGD91-phox; CY24B_HUMAN; CYBB; Cytochrome b 245; beta polypeptide; Cytochrome b558; beta chain; Cytochrome b558; subunit beta; Cytochrome b-245 heavy chain; Cytochrome b558 subunit beta; GP91 PHOX; gp91-1; gp91-phox; GP91PHOX; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; NOX2 ; p22 phagocyte B-cytochrome; P91 PHOX; p91-PHOX; Superoxide-generating NADPH oxidase heavy chain subunit	Human	E. coli

Cat. No.	Product Name

HY-14268S

Febuxostat D9

Febuxostat-d₉ is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with a Ki of 0.6 nM.

HY-B0831S

Buprofezin-d6

Buprofezin-d₆ is the deuterium labeled Buprofezin. Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase[1][2].

HY-14268S1

Febuxostat-d7

Febuxostat-d₇ is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is selective xanthine oxidase inhibitor with a Ki of 0.6 nM[1].
HY-N0088S

Apocynin-d3

Apocynin-d₃ is the deuterium labeled Apocynin[1]. Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[2][3][4].
HY-I0637S

Isovanillin-d3

Isovanillin-d₃ is the deuterium labeled Isovanillin[1]. Isovanillin is an aldehyde oxidase inhibitor[2]. Antispasmodic activities[3]. Antidiarrheal activities[4].

HY-14605BS

Rasagiline-13C3 mesylate racemic
Rasagiline-¹³C₃ (mesylate racemic) is a ¹³C-labeled Rasagiline mesylate racemic. Rasagiline mesylate racemic is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor[1].

HY-Y0127S

D(-)-2-Aminobutyric acid-d6

D(-)-2-Aminobutyric acid-d₆ is the deuterium labeled D(-)-2-Aminobutyric acid. D(-)-2-Aminobutyric acid is a substrate of D-amino acid oxidase.

HY-Y0882S1

Hydroxylamine-d3 hydrochloride
Hydroxylamine-d₃ (hydrochloride) is the deuterium labeled Hydroxyamine hydrochloride[1]. Hydroxyamine hydrochloride is a selective monoamine oxidase (MAO) inhibitor used for inhibiting of platelet aggregation. Hydroxyamine hydrochloride is an intermediate of organic synthesis[2].

HY-B1111S1

Amitraz-d3
Amitraz-d₃ is the deuterium labeled Amitraz. Amitraz is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.

HY-B0219S

Allopurinol-d2
Allopurinol-d₂ is deuterium labeled Allopurinol. Allopurinol is a potent xanthine oxidase inhibitor (IC50 values of 0.2 to 50 μM). Allopurinol can be used for the research of hyperuricemia and gout. Antileishmanial effect[1][2].

HY-W015490S

1,4-Naphthoquinone-d6
1,4-Naphthoquinone-d₆ is the deuterium labeled 1,4-Naphthoquinone[1]. 1,4-Naphthoquinone is a potential pharmacophore for inhibition of both MAO (monoamine oxidase) and DNA topoisomerase activities, this latter associated with antitumor activity[2].

HY-B0534S1

Moclobemide-d4
Moclobemide-d₄ is deuterium labeled Moclobemide. Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A[1].Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

HY-121246S

Fluorofenidone-d3
Fluorofenidone-d₃ is deuterium labeled Fluorofenidone. Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway[1][2].

HY-113056AS

N1-Acetylspermidine-d6 hydrochloride

N1-Acetylspermidine-d₆ (hydrochloride) is the deuterium labeled N1-Acetylspermidine hydrochloride. N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA[1][2][3].

HY-13653S

(+/-)-Epigallocatechin Gallate-13C3

(+/-)-Epigallocatechin Gallate-¹³C₃ is the ¹³C-labeled (-)-Epigallocatechin Gallate. (-)-Epigallocatechin Gallate is a tea flavonoid with potent antioxidant, antiinflammatory, and anticarcinogenic properties. (-)-Epigallocatechin Gallate is reported to inhibit EGFR signaling and thereby exert anticancer effects[1]. (-)-Epigallocatechin Gallate (EGCG) is a glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) inhibitor. Epigallocatechin-3-gallate induces oxidative phosphorylation (OXPHOS) by activating cytochrome c oxidase.

HY-17447AS

(1S,2R)-Tranylcypromine-d5 hydrochloride

(1S,2R)-Tranylcypromine-d₅ (hydrochloride) is the deuterium labeled Tranylcypromine hydrochloride[1]. Tranylcypromine hydrochloride (SKF 385 hydrochloride) is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Tranylcypromine hydrochloride inhibits LSD1, MAO A and MAO B with IC50s of 20.7, 2.3 and 0.95 μM, respectively. Tranylcypromine hydrochloride can be used for the research of depression[2][3][4].

HY-101392S1

Harmane-d2

Harmane-d₂ is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

HY-101392S

Harmane-d1

Harmane-d is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

HY-70057S1

Safinamide-d4-1

Safinamide-d₄-1 is deuterium labeled Safinamide. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 µM) over MAO-A (IC50=580 µM)[1]. Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8 µM) than at resting (IC50=262 µM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al[2][3].

Cat. No.	Product Name	Application	Reactivity

HY-P80762

*NADPH Oxidase* 4 Rabbit pAb** NADPH oxidase 4; Kidney oxidase-1; KOX-1; KOX1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase; NOX4; RENOX		Human, Mouse, Rat
Rabbit Polyclonal Antibody to NADPH oxidase 4

HY-P80731

KDM1A (YP7017) Mouse mAb KDM1A; AOF2; KDM1; KIAA0601; LSD1; Lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2		Human, Mouse, Monkey
Mouse Monoclonal Antibody to KDM1/LSD1

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Natural
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