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Results for "

oxime

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Antibiotic (1) Apoptosis (1) Biochemical Assay Reagents (1) CDK (4) Cholinesterase (ChE) (4) Drug Metabolite (2) Drug-Linker Conjugates for ADC (1) EGFR (1) Endogenous Metabolite (3) Fungal (3) Glucosidase (2) GSK-3 (4) JNK (1) Lipoxygenase (1) Monoamine Oxidase (1) Parasite (2) Reactive Oxygen Species (1)
By Research Areas:	Cancer (6) Endocrinology (1) Infection (5) Inflammation/Immunology (3) Neurological Disease (7)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0778

Milbemycin oxime	Antibiotic Parasite	Infection
Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .

HY-121035

7BIO 7-Bromoindirubin-3-oxime	CDK GSK-3	Neurological Disease
7BIO (7-Bromoindirubin-3-Oxime) is the derivate of indirubin. 7BIO (7-Bromoindirubin-3-Oxime) has inhibitory effects against cyclin-dependent kinase-5 (CDK5) and glycogen synthase kinase-3β (GSK3β). 7BIO (7-Bromoindirubin-3-Oxime) inhibits Aβ oligomer-induced neuroinflammation, synaptic impairments, tau hyper-phosphorylation, activation of astrocytes and microglia, and attenuates Aβ oligomer-induced cognitive impairments in mice ^[1].

HY-157224

Zearalanone carboxymethoxyl oxime

Others Others

Zearalanone carboxymethoxyl oxime is a hapten that binds to the free amine on BSA .

Zearalanone carboxymethoxyl oxime	Others	Others
Zearalanone carboxymethoxyl oxime is a hapten that binds to the free amine on BSA .

HY-118793

Inosine oxime 6-Hydroxyadenosine	Endogenous Metabolite	Others
Inosine oxime (6-Hydroxyadenosine) is an endogenous metabolite in the course of cell metabolism by cytochrome P450, by oxidative stress or by deviating nucleotide biosynthesis. Inosine oxime has toxic and mutagenic for procaryotic and eucaryotic cells .

HY-W145605

*D-Glucosamine oxime* hydrochloride**	Biochemical Assay Reagents	Others
D-Glucosamine Oxime Hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-139254

Indirubin-3′-oxime IDR3O; I3O	CDK GSK-3 JNK	Neurological Disease
Indirubin-3′-oxime (IDR3O), a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Indirubin-3′-oxime directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3), with IC₅₀s of 0.8 μM, 1.4 μM, and 1.0 μM, respectively. Indirubin-3′-oxime can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes .

HY-135325

4-Hydroxyacetophenone oxime	Drug Metabolite	Inflammation/Immunology
4-Hydroxyacetophenone oxime is an impurity of Acetaminophen (Paracetamol). Acetaminophen is a potent cyclooxygenase-2 (COX-2) and hepatic N-acetyltransferase 2 (NAT2) inhibitor, and used antipyretic and analgesic agent .

HY-135194

Risperidone E-oxime	Drug Metabolite	Others
Risperidone E-oxime is an impurity of Risperidone . Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively .

HY-10580

GSK 3 Inhibitor IX 5+ Cited Publications 6-Bromoindirubin-3'-oxime; BIO; MLS 2052	GSK-3 CDK Apoptosis	Cancer
GSK 3 Inhibitor IX (6-Bromoindirubin-3'-oxime; BIO) is a potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex with IC₅₀s of 5 nM/320 nM/80 nM for (GSK-3α/β)/CDK1/CDK5, respectively.

HY-146981

α-Glucosidase-IN-3

Glucosidase Inflammation/Immunology

α-Glucosidase-IN-3 is an oleanolic acid (OA) oxime ester derivativ eagainst α-glucosidase(IC₅₀=0.35 µM) and α-amylase.

α-Glucosidase-IN-3	Glucosidase	Inflammation/Immunology
α-Glucosidase-IN-3 is an oleanolic acid (OA) oxime ester derivativ eagainst α-glucosidase(IC₅₀=0.35 µM) and α-amylase.

HY-157047

Anticancer agent 171	Others	Cancer
Anticancer agent 171 (Compound 6a) is an oxime analogue. Anticancer agent 171 has anticancer activity against HCT116 cells with an IC₅₀ value of 3.43 μM. Anticancer agent 171 can be used for the research of cancer .

HY-146984

α-Amylase-IN-2	Glucosidase	Inflammation/Immunology
α-Glucosidase-IN-3 is an oleanolic acid (OA) oxime ester derivative against α-glucosidase (IC₅₀=1.28 µM) and α-amylase (IC₅₀=3.8 µM) .

HY-U00283

Falintolol, (Z)-

Adrenergic Receptor Endocrinology

Falintolol, (Z)-, a new β-adrenergic antagonist, is characterized by the presence of an oxime function.

Falintolol, (Z)-	Adrenergic Receptor	Endocrinology
Falintolol, (Z)-, a new β-adrenergic antagonist, is characterized by the presence of an oxime function.

HY-19807

Indirubin-3'-monoxime 3 Publications Verification Indirubin-3'-oxime	GSK-3 CDK Lipoxygenase	Cancer
Indirubin-3'-monoxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase, with IC₅₀s of 22 nM and 7.8-10 µM, respectively; Indirubin-3'-monoxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC₅₀s of 100 and 180 nM.

HY-156399

KR-27425

Endogenous Metabolite Neurological Disease

AChE activator 1 (compound 13) is a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase(AChE) .
HY-157532

AChE-IN-55

Cholinesterase (ChE) Others

AChE-IN-55, 1,2,3-Triazole oxime derivative, is an inhibitor of AChE(4.8 μM) .

KR-27425	Endogenous Metabolite	Neurological Disease
AChE activator 1 (compound 13) is a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase(AChE) .

AChE-IN-55	Cholinesterase (ChE)	Others
AChE-IN-55, 1,2,3-Triazole oxime derivative, is an inhibitor of AChE(4.8 μM) .

HY-163397

Antibacterial agent 196	Fungal	Infection
Antibacterial agent 196 (compound 6b) is a coumarin derivative containing oxime ether structure, and shows antifungal activity, with the EC₅₀ of 0.46 μg/mL against Rhizoctonia solani .

HY-W011108

Obidoxime dichloride	Cholinesterase (ChE)	Neurological Disease
Obidoxime dichloride is a non-full spectrum oxime agent and can be used as an antidote for organophosphate nerve agent poisoning. Obidoxime dichloride reactivates sarin-inhibited acetylcholinesterase (AChE) and reduces acute toxicity of sarin-evaluated .

HY-B1200

Pralidoxime chloride 2-PAM chloride	Cholinesterase (ChE)	Neurological Disease
Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning .

HY-B1738

Pralidoxime
Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning .

HY-B1738A

Pralidoxime iodide	Cholinesterase (ChE)	Neurological Disease
Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning .

HY-153263

(Aminooxy)acetamide-Val-Cit-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
(Aminooxy)acetamide-Val-Cit-PAB-MMAE (MMAE 5) is an intermediate used in the synthetic preparation of drug-linker conjugates for ADC. (Aminooxy)acetamide-Val-Cit-PAB-MMAE is conjugated to polyamide via oxime bond formation to form MMAE polyamide conjugate. Then MMAE polyamide conjugate can be conjugated to Trastuzumab, to make ADC .

HY-163297

Antifungal agent 90	Fungal	Infection
Antifungal agent 90 (Compound 7n) is an antifungal agent that inhibits ergosterol biosynthesis. Antifungal agent 90 showed excellent antifungal activity against Valsa mali and Botrytis cinerea with EC₅₀ values respectively. 4.26 and 1.41 μg/mL .

HY-129476

L-Canaline	Parasite Endogenous Metabolite	Infection Cancer
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite *Plasmodium falciparum* with an IC₅₀ of 297 nM. L-Canaline has anticancer and antiproliferative effects .

HY-146116

Antifungal agent 32	Fungal	Infection
Antifungal agent 32 (compound 1a) is a potent antifungal agent. Antifungal agent 32 inhibits Candida albicans filamentation and biofilm formation. Antifungal agent 32 inhibits the morphological switching of Candida albicans and its adherence to epithelial cells. Antifungal agent 32 can be used for Candida albicans infections research .

HY-155137

CHBO4	Monoamine Oxidase Reactive Oxygen Species	Neurological Disease
CHBO4 is a potent, reversible, competitive, and selective hMAO-B inhibitor with an IC₅₀ value of 0.031 μM in CHBO subseries and an K_i value of 0.010 ± 0.005 μM. CHBO4 reduce cell damage by scavenging intracellular reactive oxygen species (ROS). CHBO4 can be used for Parkinson's Disease (PD) research .

HY-103441

JNJ28871063 hydrochloride	EGFR	Cancer
JNJ28871063 hydrochloride is an orally active, highly selective and ATP competitive pan-ErbB kinase inhibitor with IC₅₀ values of 22 nM, 38 nM, and 21 nM for ErbB1, ErbB2, and ErbB4, respectively. JNJ28871063 hydrochloride inhibits phosphorylation of functionally important tyrosine residues in both EGFR and ErbB2. JNJ28871063 hydrochloride crosses the blood-brain barrier and has antitumor activity in human tumor xenograft models that overexpress EGFR and ErbB2 .

*D-Glucosamine oxime* hydrochloride**	Biochemical Assay Reagents
D-Glucosamine Oxime Hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Milbemycin oxime	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Antibiotic Parasite
Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .

L-Canaline	Infection Structural Classification other families Classification of Application Fields Source classification Amino acids Plants Endogenous metabolite Disease Research Fields	Parasite Endogenous Metabolite
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite *Plasmodium falciparum* with an IC₅₀ of 297 nM. L-Canaline has anticancer and antiproliferative effects .

Inosine oxime 6-Hydroxyadenosine	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Inosine oxime (6-Hydroxyadenosine) is an endogenous metabolite in the course of cell metabolism by cytochrome P450, by oxidative stress or by deviating nucleotide biosynthesis. Inosine oxime has toxic and mutagenic for procaryotic and eucaryotic cells .

KR-27425	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
AChE activator 1 (compound 13) is a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase(AChE) .

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oxime

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Natural
Products