p27

By Targets:	Akt (1) Antifolate (1) Apoptosis (9) Aurora Kinase (1) Autophagy (1) Bacterial (1) Bcl-2 Family (1) Biochemical Assay Reagents (1) c-Myc (1) Caspase (1) E1/E2/E3 Enzyme (7) EGFR (1) Fatty Acid Synthase (FASN) (1) Interleukin Related (1) NF-κB (2) PARP (1) Pim (2) PPAR (1) Proteasome (1) PTEN (1) ROS Kinase (2) Sirtuin (1) TNF Receptor (1) VD/VDR (1)
By Research Areas:	Cancer (18) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1)
Click Chemistry:	Alkynes (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114712

SJ572403 2 Publications Verification SJ403	Others	Others
SJ572403 (SJ403) is a p27 ^Kip1 inhibitor. SJ572403 has high specificity for specific regions within the D2 subdomain of p27-KID with a K_d value of 2.2 mM. SJ572403 can be used for the research of diseases associated with intrinsically disordered proteins (IDPs) .

HY-123578

NSC689857	EGFR E1/E2/E3 Enzyme	Cancer
NSC689857 is a potent EGFR and SCF ^SKP2 inhibitor with an IC₅₀ value of 36 μM for Skp2-Cks1. NSC689857 can inhibit p27 ubiquitylation (IC₅₀=30 μM). NSC689857 has varied activity across cancer types, with more activity against leukemia cell lines than others .

HY-15694

SMIP004 3 Publications Verification	E1/E2/E3 Enzyme Apoptosis	Cancer
SMIP004 is a SKP2 E3 ligase inhibitor, which downregulates SKP2 and to stabilise p27. SMIP004 is a cancer cell selective apoptosis inducer of human prostate cancer cells .

HY-16230

GGTI-2417	ROS Kinase Apoptosis	Cancer
GGTI-2417 is a potent and selective inhibitor of GGTase I. GGTI-2417 inhibits the Cdk2-mediated phosphorylation of p27 ^Kip1 at Thr187 and accumulates p27 ^Kip1 in the nucleus. GGTI-2417 also induces breast cancer cell apoptosis .

HY-P1404

R8-T198wt

Pim Cancer

R8-T198wt is a cell-permeable carboxyl-terminal p27 ^Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase .

R8-T198wt	Pim	Cancer
R8-T198wt is a cell-permeable carboxyl-terminal p27 ^Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase .

HY-15301

CC0651	E1/E2/E3 Enzyme	Cancer
CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. CC0651 potently (IC₅₀=1.72 μM) inhibits the ubiquitination of p27 ^Kip1, as confirmed by dose-response analysis.

HY-126075A

WS-383	E1/E2/E3 Enzyme	Cancer
WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC₅₀ of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2 .

HY-16231

GGTI-2418	ROS Kinase Apoptosis	Cancer
GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2418 inhibits GGTase I and FTase activities with IC₅₀s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors .

HY-100237

SZL P1-41 Maximum Cited Publications 9 Publications Verification	E1/E2/E3 Enzyme Apoptosis	Cancer
SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. SZL P1-41, like Skp2 deficiency, augments p27-mediated apoptosis/senescence, while it impairs Akt-driven glycolysis. Anti-tumor activities .

HY-135199

Ubiquitination-IN-1	E1/E2/E3 Enzyme	Cancer
Ubiquitination-IN-1 (compound 24) is a ubiquitination and Cksl-Skp2 protein-protein interaction (IC₅₀=0.17 μM) inhibitor. Ubiquitination-IN-1 increases levels of p27. Ubiquitination-IN-1 has the potential for treatment disease by blocking the degradation of tumor suppressors .

HY-114310

VDR agonist 1	VD/VDR Apoptosis	Cancer
VDR agonist 1 (compound 28) is a nonsteroidal Vitamin D receptor (VDR) agonist, with an IC₅₀ of 690 nM in MCF-7 cells. VDR agonist 1 arrests the cell cycle through the up-regulation of p21 and p27, promotes apoptosis by increasing the expression of BAX and decrease the expression of Bcl-2 .

HY-126075

WS-383 free base	E1/E2/E3 Enzyme	Cancer
WS-383 free base is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC₅₀ of 11 nM. WS-383 free base inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2 .

HY-12286

PI-1840	Proteasome Apoptosis Autophagy Caspase Bcl-2 Family NF-κB PARP	Cancer
PI-1840 is a potent and selective chymotrypsin-like (CT-L) inhibitor for with an IC₅₀ value of 27 nM. PI-1840 inhibits cell proliferation and arrest cell cycle at G2/M phase. PI-1840 induces apoptosis and induces autophagy. PI-1840 induces the accumulation of proteasome substrates p27, Bax, and IκB-α .

HY-W412264

Pim-1/2 kinase inhibitor 1	Pim	Cancer
Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of 4E-BP1 and p27 ^Kip1. Pim-1/2 kinase inhibitor 1 can be used in study of cancer, especially prostate cancer .

HY-115932

Aurora kinase-IN-1	Aurora Kinase Apoptosis	Cancer
Aurora kinase-IN-1 (Compound 9) is a potent inhibitor of aurora kinase. Aurora kinase-IN-1 upregulates the expression of G1 cell cycle inhibitory proteins including p21 and p27, and G1 progressive cyclin D1, and downregulates G1-to-S progressive cyclins, resulting in cell cycle arrest at the G1/S boundary. Aurora kinase-IN-1 also induces apoptosis. Aurora kinase-IN-1 is a lead compound for chemotherapeutic agents .

HY-N0704

Agrimol B	Sirtuin PPAR Fatty Acid Synthase (FASN) c-Myc Bacterial	Infection Metabolic Disease Cancer
Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and *p27* .

HY-149216

Anticancer agent 103

Others Cancer

Anticancer agent 103 (Compound 2k) is a potent anticancer agent .
HY-N3825

ent-Kaurane-3α,16β,17-triol

Apoptosis Cancer

ent-Kaurane-3α,16β,17-triol (Compound 3) is an anticancer agent. ent-Kaurane-3α,16β,17-triol induces apoptosis in HCT116 cells .

Anticancer agent 103	Others	Cancer
Anticancer agent 103 (Compound 2k) is a potent anticancer agent .

ent-Kaurane-3α,16β,17-triol	Apoptosis	Cancer
ent-Kaurane-3α,16β,17-triol (Compound 3) is an anticancer agent. ent-Kaurane-3α,16β,17-triol induces apoptosis in HCT116 cells .

HY-10446

Pralatrexate 4 Publications Verification	Antifolate Apoptosis	Cancer
Pralatrexate is an antifolate and is a potent dihydrofolate reductasean (DHFR) inhibitor with a K_i of 13.4 pM. Pralatrexate is a substrate for folylpolyglutamate synthetase with improved cellular uptake and retention. Pralatrexate has antitumor activities and has the potential for relapsed/refractory T-cell lymphoma treatment . Pralatrexate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N8884

Coelonin	PTEN Akt NF-κB Interleukin Related TNF Receptor	Inflammation/Immunology
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and *p27Kip1* degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein .

HY-D0014

Brilliant blue G-250 2 Publications Verification	Biochemical Assay Reagents	Others
Brilliant Blue G-250 is a dye commonly used for the visualization of proteins separated by SDS-PAGE, offering a simple staining procedure and high quantitation. In the Bradford protein assay, protein concentrations are determined by the absorbance at 595 nm due to the binding of Brilliant Blue G-250 to proteins. Brilliant Blue G-250 is a safe highly selective P2×7R antagonist with promising consequent inactivation of NLRP3 inflammasome .

Cat. No.	Product Name	Type

HY-D0014

Brilliant blue G-250 2 Publications Verification	Biochemical Assay Reagents
Brilliant Blue G-250 is a dye commonly used for the visualization of proteins separated by SDS-PAGE, offering a simple staining procedure and high quantitation. In the Bradford protein assay, protein concentrations are determined by the absorbance at 595 nm due to the binding of Brilliant Blue G-250 to proteins. Brilliant Blue G-250 is a safe highly selective P2×7R antagonist with promising consequent inactivation of NLRP3 inflammasome .

Brilliant blue G-250

2 Publications Verification

Biochemical Assay Reagents

Brilliant Blue G-250 is a dye commonly used for the visualization of proteins separated by SDS-PAGE, offering a simple staining procedure and high quantitation. In the Bradford protein assay, protein concentrations are determined by the absorbance at 595 nm due to the binding of Brilliant Blue G-250 to proteins. Brilliant Blue G-250 is a safe highly selective P2×7R antagonist with promising consequent inactivation of NLRP3 inflammasome .

Cat. No.	Product Name	Target	Research Area

HY-P1404

R8-T198wt

Pim Cancer

R8-T198wt is a cell-permeable carboxyl-terminal p27 ^Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase .

R8-T198wt	Pim	Cancer
R8-T198wt is a cell-permeable carboxyl-terminal p27 ^Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0704

Agrimol B	Agrimonia pilosa Ledeb. Structural Classification Classification of Application Fields Rosaceae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Sirtuin PPAR Fatty Acid Synthase (FASN) c-Myc Bacterial
Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and *p27* .

HY-N3825

ent-Kaurane-3α,16β,17-triol	Structural Classification Terpenoids Source classification Euphorbia stracheyi Boiss. Diterpenoids Euphorbiaceae Plants	Apoptosis
ent-Kaurane-3α,16β,17-triol (Compound 3) is an anticancer agent. ent-Kaurane-3α,16β,17-triol induces apoptosis in HCT116 cells .

HY-N8884

Coelonin	Structural Classification Appendicula reflexa Blume Orchidaceae Source classification Phenols Polyphenols Plants	PTEN Akt NF-κB Interleukin Related TNF Receptor
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and *p27Kip1* degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein .

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70037

	CDKN1B Protein, Human (His) rHuCyclin-dependent kinase inhibitor 1B/CDKN1B, His; Cyclin-Dependent Kinase Inhibitor 1B; Cyclin-Dependent Kinase Inhibitor p27; p27Kip1; CDKN1B; KIP1	Human	E. coli
	The CDKN1B protein is a key cell cycle regulator that inhibits CDK2 when bound to cyclin A, thereby inhibiting G1 phase progression. It exhibits significant inhibitory effects on cyclin E- and cyclin A-CDK2 complexes. CDKN1B Protein, Human (His) is the recombinant human-derived CDKN1B protein, expressed by E. coli , with N-6*His labeled tag. The total length of CDKN1B Protein, Human (His) is 198 a.a., with molecular weight of ~30.0 kDa.

HY-P71583

	LAMTOR1 Protein, Human (His) C11orf59; LAMTOR1; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; Lipid raft adaptor protein p18; LTOR1_HUMAN; p18; p27Kip1-releasing factor from RhoA; p27RF-Rho; PDRO; PP7157; Protein associated with DRMs and endosomes; Ragulator complex protein LAMTOR1; ragulator complex protein PDRO; Ragulator1; RhoA activator C11orf59	Human	E. coli
	The LAMTOR1 protein is an important component of the Ragulator complex and plays dual roles in amino acid sensing and mTORC1 activation. It acts as a guanine nucleotide exchange factor (GEF) for Rag GTPases and mediates their recruitment to the lysosomal membrane. LAMTOR1 Protein, Human (His) is the recombinant human-derived LAMTOR1 protein, expressed by E. coli , with N-His labeled tag. The total length of LAMTOR1 Protein, Human (His) is 160 a.a., with molecular weight of ~24 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P80256

p27 KIP 1 Antibody	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse, Rat
p27 KIP 1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 22 kDa, targeting to p27 KIP 1. It can be used for WB,ICC/IF,IHC-P,FC,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P81749

Phospho-p27 Kip 1 (Ser10) Antibody (YA1494)

CDKN1B; KIP1; Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; p27Kip1
WB, IHC-P, IP Human, Mouse, Rat
HY-P82004

Proteasome alpha 6 Antibody (YA1749)

proteasome subunit alpha 6; IOTA; p27K; PROS27
WB, ICC/IF Human, Mouse, Rat

Cat. No.	Product Name		Classification

HY-10446

Pralatrexate 4 Publications Verification		Alkynes
Pralatrexate is an antifolate and is a potent dihydrofolate reductasean (DHFR) inhibitor with a K_i of 13.4 pM. Pralatrexate is a substrate for folylpolyglutamate synthetase with improved cellular uptake and retention. Pralatrexate has antitumor activities and has the potential for relapsed/refractory T-cell lymphoma treatment . Pralatrexate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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p27

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