Search Result

Results for "

p38

" in MedChemExpress (MCE) Product Catalog:

By Targets:	p38 MAPK (151) Akt (3) Angiotensin Receptor (1) Antibiotic (1) AP-1 (2) Apoptosis (33) Arginase (1) Aryl Hydrocarbon Receptor (4) Aurora Kinase (2) Autophagy (67) Bacterial (5) Bcl-2 Family (4) c-Kit (1) c-Myc (1) Calcium Channel (5) CaMK (1) Casein Kinase (7) Caspase (8) Cholinesterase (ChE) (1) COX (7) Dengue virus (1) DNA/RNA Synthesis (1) EGFR (1) Endogenous Metabolite (7) Enterovirus (1) Epigenetic Reader Domain (1) ERK (14) Flavivirus (1) FLT3 (1) Formyl Peptide Receptor (FPR) (1) Fungal (5) HCV (1) HDAC (1) HIV (3) HSP (1) IAP (1) IKK (2) Interleukin Related (7) Isotope-Labeled Compounds (4) JAK (3) JNK (14) Keap1-Nrf2 (1) Leukotriene Receptor (1) MAP3K (4) MAPKAPK2 (MK2) (4) MDM-2/p53 (1) MEK (2) Microtubule/Tubulin (2) Mitochondrial Metabolism (2) Mitophagy (2) MMP (2) MNK (1) Neurokinin Receptor (1) NF-κB (17) NO Synthase (4) Nuclear Factor of activated T Cells (NFAT) (1) Organoid (4) P2Y Receptor (3) Parasite (5) PARP (4) Phosphatase (5) Phosphodiesterase (PDE) (1) Phospholipase (2) PI3K (1) PKA (5) PKC (6) Polo-like Kinase (PLK) (1) Potassium Channel (3) PPAR (1) Prostaglandin Receptor (1) PROTACs (4) Raf (3) Reactive Oxygen Species (6) ROCK (5) SHP2 (2) Sirtuin (1) Src (7) STAT (1) TGF-beta/Smad (1) TGF-β Receptor (3) TNF Receptor (12) Toll-like Receptor (TLR) (2) Topoisomerase (1) Tyrosinase (2) VEGFR (3) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (95) Cardiovascular Disease (14) Endocrinology (5) Infection (14) Inflammation/Immunology (112) Metabolic Disease (10) Neurological Disease (22)

By Targets:

p38 MAPK (151)

Akt (3)

Angiotensin Receptor (1)

Antibiotic (1)

AP-1 (2)

Apoptosis (33)

Arginase (1)

Aryl Hydrocarbon Receptor (4)

Aurora Kinase (2)

Autophagy (67)

Bacterial (5)

Bcl-2 Family (4)

c-Kit (1)

c-Myc (1)

Calcium Channel (5)

CaMK (1)

Casein Kinase (7)

Caspase (8)

Cholinesterase (ChE) (1)

COX (7)

Dengue virus (1)

DNA/RNA Synthesis (1)

EGFR (1)

Endogenous Metabolite (7)

Enterovirus (1)

Epigenetic Reader Domain (1)

ERK (14)

Flavivirus (1)

FLT3 (1)

Formyl Peptide Receptor (FPR) (1)

Fungal (5)

HCV (1)

HDAC (1)

HIV (3)

HSP (1)

IAP (1)

IKK (2)

Interleukin Related (7)

Isotope-Labeled Compounds (4)

JAK (3)

JNK (14)

Keap1-Nrf2 (1)

Leukotriene Receptor (1)

MAP3K (4)

MAPKAPK2 (MK2) (4)

MDM-2/p53 (1)

MEK (2)

Microtubule/Tubulin (2)

Mitochondrial Metabolism (2)

Mitophagy (2)

MMP (2)

MNK (1)

Neurokinin Receptor (1)

NF-κB (17)

NO Synthase (4)

Nuclear Factor of activated T Cells (NFAT) (1)

Organoid (4)

P2Y Receptor (3)

Parasite (5)

PARP (4)

Phosphatase (5)

Phosphodiesterase (PDE) (1)

Phospholipase (2)

PI3K (1)

PKA (5)

PKC (6)

Polo-like Kinase (PLK) (1)

Potassium Channel (3)

PPAR (1)

Prostaglandin Receptor (1)

PROTACs (4)

Raf (3)

Reactive Oxygen Species (6)

ROCK (5)

SHP2 (2)

Sirtuin (1)

Src (7)

STAT (1)

TGF-beta/Smad (1)

TGF-β Receptor (3)

TNF Receptor (12)

Toll-like Receptor (TLR) (2)

Topoisomerase (1)

Tyrosinase (2)

VEGFR (3)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (95)

Cardiovascular Disease (14)

Endocrinology (5)

Infection (14)

Inflammation/Immunology (112)

Metabolic Disease (10)

Neurological Disease (22)

229

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

p38 MAP Kinase Inhibitor III 1 Publications Verification	p38 MAPK	Inflammation/Immunology
p38 MAP Kinase Inhibitor III (compound 7h) is a p38 MAPK inhibitor with an ₅₀ of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with ₅₀ values of 0.37 μM and 0.044 μM, respectively .

p38 MAPK-IN-4	p38 MAPK	Inflammation/Immunology
p38 MAPK-IN-4 (compound 6) is a p38 MAPK inhibitor with an ₅₀ of 35 nM .

p38 MAPK-IN-1 5+ Cited Publications	p38 MAPK Autophagy	Inflammation/Immunology
p38 MAPK-IN-1 (Compound 4) is a novel potent and selective inhibitor of p38 MAPK with IC₅₀ of 68 nM. p38 MAPK-IN-1 shows sustained levels, low clearance and good bioavailability.

p38 Kinase inhibitor 5	p38 MAPK	Inflammation/Immunology
p38 Kinase inhibitor 5 (AA6) is a potent *p38* kinase inhibitor with an IC₅₀ of 403.57 nM. p38 Kinase inhibitor 5 has anti-inflammatory activity .

p38 MAPK-IN-2	p38 MAPK Autophagy	Cancer
p38 MAPK-IN-2 is an inhibitor of p38 kinase.

p38 MAPK-IN-3	p38 MAPK Apoptosis Reactive Oxygen Species	Cancer
p38 MAPK-IN-3 (Compound 2c) is a p38α MAPK inhibitor. p38 MAPK-IN-3 has antitumor activities and induces apoptosis and ROS .

p38 MAP Kinase Inhibitor Ⅵ	p38 MAPK	Cancer
p38 MAP Kinase Inhibitor VI (compound c32) is a p38 MAPK inhibitor with an inhibition rate of 24% .

p38 Kinase inhibitor 4	p38 MAPK	Cancer
p38 Kinase inhibitor 4 (compound 135) is a potent *p38* inhibitor .

p38 MAP Kinase Inhibitor IV	p38 MAPK	Inflammation/Immunology
p38 MAP Kinase Inhibitor IV is a highly specific ATP-competitive p38α MAPK inhibitor with IC₅₀s of 0.13 and 0.55 μM for p38α and p38β MAPK, respectively .

p38-α MAPK-IN-4	p38 MAPK	Neurological Disease Inflammation/Immunology
p38-α MAPK-IN-4 (Compound 69) is a selective p38α MAPK inhibitor with an IC₅₀ of 1.5 µM. p38-α MAPK-IN-4 rapidly and strongly prevents the development of mechanical allodynia (MA) in vivo .

p38-α MAPK-IN-5	p38 MAPK	Inflammation/Immunology
p38-α MAPK-IN-5 (compound 4e) is a potent *p38α* inhibitor with IC₅₀s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38α, p38 β, p38γ, p38δ, respectively. p38-α MAPK-IN-5 has anti-inflammatory effect. p38-α MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research .

p38-α MAPK-IN-1 1 Publications Verification	p38 MAPK Autophagy	Others
p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC₅₀ of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay .

p38-α MAPK-IN-7	p38 MAPK	Neurological Disease
p38-α MAPK-IN-7 (compound 4) is a *p38α-MAPK* inhibitor with an IC₅₀ value of 98.7 nM. p38-α MAPK-IN-7 protects neuronal cells from dexamethasone-induced ROS production .

p38-α MAPK-IN-6	p38 MAPK	Cancer
p38-α MAPK-IN-6 (compound 3a) is a *p38α* mitogen-activated protein kinase inhibitor .

p38α inhibitor 4	p38 MAPK	Cancer
p38α inhibitor 4 (compound 10) is a selective and allosteric *p38α* inhibitor with an IC₅₀ value of 1.2 μM. p38α inhibitor 4 exhibits no activity against p38β, p38γ, and p38δ .

p38α inhibitor 1	p38 MAPK Autophagy	Inflammation/Immunology
p38α inhibitor 1 is a *p38α* inhibitor extracted from patent WO 2008076265 A1.

p38α inhibitor 3	p38 MAPK	Inflammation/Immunology
p38α inhibitor 3 (Comp G7) is a *p38α* inhibitor that blocks the effectiveness of myoblast differentiation .

p38α inhibitor 2	p38 MAPK	Inflammation/Immunology
p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC₅₀ of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC₅₀=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases (<30% inhibition at 10 μM concentration) and a panel of 141 other biological targets .

*TOPK-p38/JNK-IN-1*	JNK	Cancer
TOPK-p38/JNK-IN-1 (Compound B12) is an orally active *TOPK-p38/JNK* signaling pathway inhibitor with the IC₅₀ value of 2.14 µM for NO production. TOPK-p38/JNK-IN-1 shows anti-inflammatory activities. TOPK-p38/JNK-IN-1 also inhibits phosphorylate downstream related proteins and avoids degradation of TOPK .

(aS)-PH-797804	p38 MAPK	Inflammation/Immunology
(aS)-PH-797804 is a selective p38 MAPK inhibitor with IC₅₀ values for p38 α /β of 26 nM and 102 nM, respectively. (aS)-PH-797804 has anti-inflammatory activity .

SR-3737	JNK p38 MAPK	Neurological Disease
SR-3737 is a JNK3 and *p38* inhibitor (IC₅₀: 12 and 3 nM) .

Macranthoin G Methyl 3,5-dicaffeoyl quinic acid	p38 MAPK	Neurological Disease
Macranthoin G is an inhibitor of p38 MAPK. Macranthoin G protects the cytotoxicity induced by Aβ or hydrogen peroxide in neuronal cells by downregulating p38 MAPK. Macranthoin G can used in study Alzheimer’s Disease .

SB 706504	p38 MAPK	Inflammation/Immunology
SB 706504 is a potent p38 MAPK inhibitor that inhibits Lipopolysaccharides (HY-D1056)-stimulated inflammatory gene expression in macrophages in chronic obstructive pulmonary disease (COPD) .

AZ-TAK1	MAP3K	Cancer
AZ-TAK1, an ATP-competitive small molecule inhibitor of TAK1, dephosphorylates TAK1, p38, and IκB-α in lymphoma cell lines .

Mitogen-activated protein kinase 1 MAPK1	p38 MAPK NF-κB	Inflammation/Immunology
Mitogen-activated protein kinase 1 (MAPK1) can activate the downstream *p38/NF-κB* pathway. Mitogen-activated protein kinase 1 can regulate cellular processes in various sepsis-associated diseases. MAPK-catalyzed phosphorylation of substrate proteins functions as a switch to turn on or off the activity of the substrate protein .

PD 169316 10+ Cited Publications	p38 MAPK Autophagy Enterovirus	Cancer
PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor, with IC₅₀ of 89 nM. PD169316 selectively inhibits the kinase activity of the phosphorylated p38 without hindering upstream kinases to phosphorylate p38. PD169316 shows antiviral activity against Enterovirus71. PD169316 shows antiviral activity against Enterovirus71.

SSK1 1 Publications Verification	p38 MAPK Apoptosis	Inflammation/Immunology
SSK1, a senescence-specific killing compound, is a β-galactosidase-targeted proagent attenuates inflammation. SSK1 is activated by lysosomal β-galactosidase and selectively killed senescent cells through the activation of p38 MAPK and induction of apoptosis .

erythro-Austrobailignan-6	Topoisomerase Apoptosis	Cancer
erythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA topoisomerase I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK .

Doramapimod 20+ Cited Publications BIRB 796	p38 MAPK Raf Autophagy	Inflammation/Immunology Cancer
Doramapimod (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC₅₀ for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. Doramapimod has picomolar affinity for p38 kinase (K_d=0.1 nM). Doramapimod also inhibits B-Raf with an IC₅₀ of 83 nM .

CHMFL-ABL-053
CHMFL-ABL-053 (Compound 18a) is a potent, selective, and orally available BCR-ABL, SRC and *p38* kinase inhibitor with IC₅₀ values of 70, 90 and 62 nM against ABL1, SRC and p38, respectively .

VI-60	COX Phospholipase	Inflammation/Immunology
VI-60 is a dual, orally active inhibitor of cPLA₂ and COX-2, which reveals an anti-inflammtory efficacy through the inhibition of p38 MAPK/cPLA₂/COX-2/PGE₂ pathway .

SB 202474	Others	Cancer
SB 202474, a negative analog of SB203580. SB 202474, which has no ability to inhibit p38 MAPK activity and is widely used as a negative control compound in p38 MAPK studies, also suppressed melanin synthesis induction .

SB 202190 hydrochloride 75+ Cited Publications	Organoid p38 MAPK Autophagy Apoptosis	Neurological Disease Cancer
SB 202190 hydrochloride is a selective p38 MAP kinase inhibitor with IC₅₀s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 hydrochloride binds to the ATP pocket of the active recombinant human p38 kinase with a K_d of 38 nM. SB 202190 hydrochloride has anti-cancer activity . SB202190 hydrochloride induces autophagy .

EO 1428	p38 MAPK	Inflammation/Immunology
EO 1428 is a highly specific inhibitor of *p38* of the aminobenzophenone class. EO 1428 (1 μM ) markedly attenuates LPS-induced tumor necrosis factor α-converting enzyme (TACE) activity up-regulation .

Adezmapimod hydrochloride Maximum Cited Publications 400 Publications Verification SB 203580 hydrochloride; RWJ 64809 hydrochloride	Organoid p38 MAPK Autophagy Mitophagy	Inflammation/Immunology Cancer
Adezmapimod (SB 203580) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC₅₀s of 50 nM and 500 nM for *SAPK2a/p38* and *SAPK2b/p38β2, respectively. Adezmapimod hydrochloride inhibits LCK, GSK3β and PKBα with IC₅₀s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod hydrochloride is an autophagy* and mitophagy activator .

2-Stearoxyphenethyl phosphocholin	p38 MAPK	Metabolic Disease
2-Stearoxyphenethyl phosphocholin (compound 1a) is a p38 MAPK inhibitor with anticancer activity. 2-Stearoxyphenethyl phosphocholin may bind to the p38 MAPK lipid-binding pocket and has broad-spectrum anti-tumor and lipid-modulating activities .

AZD7624	p38 MAPK Autophagy	Inflammation/Immunology
AZD7624 is an inhaled *p38* inhibitor, with potent anti-inflammatory activity.

SB 202190 75+ Cited Publications	Organoid p38 MAPK Autophagy Apoptosis	Neurological Disease Cancer
SB 202190 is a selective p38 MAP kinase inhibitor with IC₅₀s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 binds to the ATP pocket of the active recombinant human p38 kinase with a K_d of 38 nM. SB 202190 has anti-cancer activity and rescued memory deficits . SB202190 induces autophagy .

2-Oleoxyphenethyl phosphocholin	p38 MAPK	Cancer
2-Oleoxyphenethyl phosphocholin (compound 1b) is a p38 MAPK inhibitor with anticancer activity. 2-Oleoxyphenethyl phosphocholin may bind to the p38 MAPK lipid-binding pocket and has broad-spectrum anti-tumor and lipid-modulating activities .

Acumapimod 1 Publications Verification BCT197	p38 MAPK Autophagy	Inflammation/Immunology
Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC₅₀ of less than 1 μM for p38α.

N-Feruloyloctopamine
N-Feruloyloctopamine is an antioxidant constituent. N-Feruloyloctopamine significantly decreases the phosphorylation levels of Akt and *p38 MAPK* .

Adezmapimod Maximum Cited Publications 400 Publications Verification SB 203580; RWJ 64809	Organoid p38 MAPK Autophagy Mitophagy	Inflammation/Immunology Cancer
Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC₅₀s of 50 nM and 500 nM for *SAPK2a/p38* and *SAPK2b/p38β2, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC₅₀s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod does not disrupt JNK activity and is an autophagy* and mitophagy activator .

TA-01	Casein Kinase p38 MAPK Autophagy	Cardiovascular Disease
TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC₅₀s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively. TA-01 acts as a cardiogenic inhibitor.

Skepinone-L CBS3830	p38 MAPK Autophagy	Inflammation/Immunology
Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor.

Losmapimod 10+ Cited Publications GSK-AHAB; GW856553X; SB856553	p38 MAPK Autophagy	Inflammation/Immunology Cancer
Losmapimod (GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pK_is of 8.1 and 7.6 for p38α and p38β, respectively .

ML3403	p38 MAPK	Inflammation/Immunology
ML3403 is a potent *p38* MAPK inhibitor with an IC₅₀ of 0.38 μM .

Cat. No.	Product Name

HY-L010

MAPK Compound Library

505 compounds

MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. In mammalian cells, four MAPK families have been clearly characterized: ERK1/2, C-Jun N-terminal kinse/stress-activated protein kinase (JNK/SAPK) , p38 kinase and ERK5. They respond to different signals. Each MAPK-related cascade consists of three enzymes that are activated in series: a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK) and a MAP kinase (MAPK). MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers.

MCE designs a unique collection of 505 MAPK signaling pathway inhibitors that act as a useful tool for MAPK-related drug screening and disease research.

Cat. No.	Product Name	Type

HY-W745090

Isomaltulose monohydrate

Biochemical Assay Reagents

Isomaltulose monohydrate is a fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Isomaltulose monohydrate can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Isomaltulose monohydrate inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM) , cathepsin G release (IC< sub>50: 2.76 μM) and chemotaxis. Isomaltulose monohydrate can improve excessive activation of neutrophils and reduce inflammation or tissue damage. A series of derivatives of Isomaltulose monohydrate are found to have inhibitory effects on FSGS-related TRPC6 functional mutants .

Cat. No.	Product Name	Target	Research Area

HY-P2319A

OVA-E1 peptide TFA	p38 MAPK JNK	Inflammation/Immunology
OVA-E1 peptide TFA, is an antagonist variant of SIINFEKL [OVA (257-264). OVA-E1 peptide, activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes .

HY-P2286

D-3

Phosphatase Cancer

D-3, a phosphorpeptide, is an efficient, simple, and specific iPSC-eliminating agent .

HY-P3031

Mitogen-activated protein kinase 1 MAPK1	p38 MAPK NF-κB	Inflammation/Immunology
Mitogen-activated protein kinase 1 (MAPK1) can activate the downstream *p38/NF-κB* pathway. Mitogen-activated protein kinase 1 can regulate cellular processes in various sepsis-associated diseases. MAPK-catalyzed phosphorylation of substrate proteins functions as a switch to turn on or off the activity of the substrate protein .

HY-P2319

OVA-E1 peptide	p38 MAPK JNK	Inflammation/Immunology
OVA-E1 peptide, is an antagonist variant of SIINFEKL [OVA (257-264). OVA-E1 peptide, activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes .

Species:	Human (10) Rat (1) Mouse (2)
Tag:	His (8) SUMO (1) Tag Free (3) GST (4) Flag (1)
Source:	E. coli Cell-free (1) Sf9 insect cells (2) Sf9 insect cells (7) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P702735

	MAPK1 Protein, Human (Flag, His) MAPK1; mitogen-activated protein kinase 1; PRKM1, PRKM2; ERK; ERK2; MAPK2; p41mapk; ERK-2; MAPK 2; p42-MAPK; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; protein tyrosine kinase ERK2; mitogen-activated protein kinase 2; extracellular signal-regulated kinase 2; p38; p40; p41; ERT1; PRKM1; PRKM2; P42MAPK	Human	E. coli

HY-P71538

	AIMP2 Protein, Human (His) Aimp2; AIMP2_HUMAN; Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Aminoacyl tRNA synthetase complex interacting multifunctional protein 2 ; ARS interacting multi functional protein 2 ; JTV 1; JTV 1 protein; JTV1; JTV1 gene; Multisynthase complex auxiliary component p38; Multisynthetase complex auxiliary component p38; p38; PRO0992; Protein JTV 1; Protein JTV-1; tRNA SYNTHETASE COFACTOR p38	Human	E. coli
	AIMP2 Protein, Human (His) plays a primary role in the initiation of α-synuclein (aSyn) aggregation.

HY-P701730

	P38β Protein, Human (Sf9) MAPK11; Mitogen-activated protein kinase 11; MAP kinase 11; MAPK 11; Mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; Stress-activated protein kinase 2b; SAPK2b; p38-2	Human	Sf9 insect cells
	The P38β protein is an important serine/threonine kinase in the MAP kinase pathway that responds to extracellular stimuli, including proinflammatory cytokines and physical stress. As part of the p38 MAPK family, P38β directly activates transcription factors that phosphorylate many proteins, including RPS6KA5/MSK1 and RPS6KA4/MSK2. P38β Protein, Human (Sf9) is the recombinant human-derived P38β protein, expressed by Sf9 insect cells , with tag free. The total length of P38β Protein, Human (Sf9) is 363 a.a., .

HY-P701731

	P38β Protein, Human (Sf9, GST) MAPK11; Mitogen-activated protein kinase 11; MAP kinase 11; MAPK 11; Mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; Stress-activated protein kinase 2b; SAPK2b; p38-2	Human	Sf9 insect cells
	The P38β protein is an important serine/threonine kinase in the MAP kinase pathway that responds to extracellular stimuli, including proinflammatory cytokines and physical stress. As part of the p38 MAPK family, P38β directly activates transcription factors that phosphorylate many proteins, including RPS6KA5/MSK1 and RPS6KA4/MSK2. P38β Protein, Human (Sf9, GST) is the recombinant human-derived P38β protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of P38β Protein, Human (Sf9, GST) is 363 a.a., .

HY-P73334

	p38 delta/MAPK13 Protein, Human (sf9, GST) Mitogen-activated protein kinase 13; MAPK 13; PRKM13; SAPK4	Human	Sf9 insect cells
	The p38 delta/MAPK13 protein is an important serine/threonine kinase in the MAP kinase pathway. It coordinates cellular responses to stimuli such as cytokines or stress and directly activates the transcription factors ELK1 and ATF2. In this cascade, p38 MAPK (including MAPK13) each phosphorylates approximately 200 to 300 substrates. p38 delta/MAPK13 Protein, Human (sf9, GST) is the recombinant human-derived p38 delta/MAPK13 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of p38 delta/MAPK13 Protein, Human (sf9, GST) is 365 a.a., with molecular weight of ~63.9 kDa.

HY-P76532

	p38 gamma/MAPK12 Protein, Human (sf9) Mitogen-activated protein kinase 12; Extracellular signal-regulated kinase 6; ERK-6; SAPK3	Human	Sf9 insect cells
	p38 gamma/MAPK12 Protein, a vital serine/threonine kinase in the MAP kinase pathway, responds to extracellular stimuli like pro-inflammatory cytokines or stress. Leading to the activation of transcription factors such as ELK1 and ATF2, p38 MAPKs phosphorylate around 200 to 300 substrates each. MAPK12 contributes to myoblast differentiation, down-regulates cyclin D1 in response to hypoxia, and inhibits cell proliferation while promoting differentiation. It phosphorylates DLG1, impacting mRNA processing during osmotic shock, regulates UV-induced checkpoint signaling, influences glucose uptake, ensures normal kinetochore localization of PLK1, and positively regulates myogenic precursor cell expansion in muscle growth and regeneration. p38 gamma/MAPK12 Protein, Human (sf9) is the recombinant human-derived p38 gamma/MAPK12 protein, expressed by Sf9 insect cells , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes) mutation. The total length of p38 gamma/MAPK12 Protein, Human (sf9) is 367 a.a., with molecular weight of ~43 kDa.

HY-P73335

	p38 alpha/MAPK14 Protein, Human (Activated, sf9, His) Mitogen-activated protein kinase 14; MAPK 14; CSBP; MXI2; SAPK2A	Human	Sf9 insect cells
	The p38 α/MAPK14 protein is an important serine/threonine kinase in the MAP kinase pathway. It can respond to stimuli such as cytokines or stress and directly activate transcription factors. In this cascade, p38 MAPK each phosphorylates approximately 200 to 300 substrates, including the downstream kinases RPS6KA5/MSK1 and RPS6KA4/MSK2, which are critical for immediate early gene induction. p38 alpha/MAPK14 Protein, Human (Activated, sf9, His) is the recombinant human-derived p38 alpha/MAPK14 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of p38 alpha/MAPK14 Protein, Human (Activated, sf9, His) is 360 a.a., with molecular weight of ~43.7 kDa.

HY-P76533

	p38 gamma/MAPK12 Protein, Human (sf9, His-GST) Mitogen-activated protein kinase 12; Extracellular signal-regulated kinase 6; ERK-6; SAPK3	Human	Sf9 insect cells
	The p38 gamma/MAPK12 protein is an important serine/threonine kinase in the MAP kinase pathway and can respond to extracellular stimuli such as pro-inflammatory cytokines or stress. p38 MAPK activates transcription factors such as ELK1 and ATF2, each of which phosphorylates approximately 200 to 300 substrates. p38 gamma/MAPK12 Protein, Human (sf9, His-GST) is the recombinant human-derived p38 gamma/MAPK12 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of p38 gamma/MAPK12 Protein, Human (sf9, His-GST) is 367 a.a., with molecular weight of ~65 kDa.

HY-P72201

	GAPDH Protein, Human (His-SUMO) G3P_HUMAN; G3PD; G3PDH; GAPD; GAPDH; Glyceraldehyde 3 phosphate dehydrogenase; glyceraldehyde 3-PDH; Glyceraldehyde-3-phosphate dehydrogenase; HEL-S-162eP; KNC-NDS6; MGC102544; OCAS; p38 component; OCT1 coactivator in S phase; 38-KD component; peptidyl cysteine S nitrosylase GAPDH	Human	E. coli
	GAPDH, a multifunctional protein, acts as a key enzyme in glycolysis, catalyzing the conversion of G3P. It also functions as a nitrosylase, impacting nuclear processes. In addition, it influences cytoskeleton organization, associates with CHP1, participates in transcript-selective translation inhibition, contributes to immune responses, and mediates nuclear events through S-nitrosylation of target proteins. GAPDH Protein, Human (His-SUMO) is the recombinant human-derived GAPDH protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of GAPDH Protein, Human (His-SUMO) is 334 a.a., with molecular weight of ~51.9 kDa.

HY-P702462

	SYP/Synaptophysin Protein, Rat (Cell-Free, His) Synaptophysin; Major synaptic vesicle protein p38	Rat	E. coli Cell-free
	The SYP/synaptophysin protein may have a dual role: organizing membrane components and aiding in vesicle targeting. Its role in the regulation of synaptic plasticity emphasizes its importance in shaping synaptic activity. SYP/Synaptophysin Protein, Rat (Cell-Free, His) is the recombinant rat-derived SYP/Synaptophysin protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SYP/Synaptophysin Protein, Rat (Cell-Free, His) is 307 a.a., with molecular weight of 34.8 kDa.

HY-P75223

	ERK2 Protein, Human (sf9, His) Mitogen-activated protein kinase 1; MAPK 1; ERT1; ERK-2; p42-MAPK	Human	Sf9 insect cells
	ERK2 Protein, a key component of the MAPK/ERK cascade, regulates diverse cellular processes such as transcription, translation, mitosis, apoptosis, endosomal dynamics, and Golgi apparatus fragmentation. Through phosphorylation, it modulates substrates including transcription factors, cytoskeletal elements, apoptosis regulators, translation regulators, protein kinases, and phosphatases. ERK2 Protein, Human (sf9, His) is the recombinant human-derived ERK2 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of ERK2 Protein, Human (sf9, His) is 360 a.a., with molecular weight of ~42 kDa.

HY-P74167

	ERK2 Protein, Mouse (sf9, His-GST) Mitogen-activated protein kinase 1; MAPK 1; ERT1; ERK-2; p42-MAPK	Mouse	Sf9 insect cells
	ERK2 protein is an essential serine/threonine kinase in the MAP kinase pathway and cooperates with MAPK1/ERK2 in the complex MAPK/ERK cascade. Stimulated by KIT and KITLG/SCF, this pathway is central to cellular function, affecting growth, adhesion, survival, and differentiation through transcription, translation, and cytoskeletal regulation. ERK2 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived ERK2 protein, expressed by Sf9 insect cells , with N-GST, N-His labeled tag. The total length of ERK2 Protein, Mouse (sf9, His-GST) is 358 a.a., with molecular weight of ~60 kDa.

HY-P74168

	ERK2 Protein, Mouse (sf9) Mitogen-activated protein kinase 1; MAPK 1; ERT1; ERK-2; p42-MAPK	Mouse	Sf9 insect cells
	ERK2 protein is an essential serine/threonine kinase in the MAP kinase pathway and cooperates with MAPK1/ERK2 in the complex MAPK/ERK cascade. Stimulated by KIT and KITLG/SCF, this pathway is central to cellular function, affecting growth, adhesion, survival, and differentiation through transcription, translation, and cytoskeletal regulation. ERK2 Protein, Mouse (sf9) is the recombinant mouse-derived ERK2 protein, expressed by Sf9 insect cells , with tag free. The total length of ERK2 Protein, Mouse (sf9) is 358 a.a., with molecular weight of ~37 kDa.

Cat. No.	Product Name	Chemical Structure

HY-W007355S1

Skatole-d8
Skatole-d₈ is the deuterium labeled Skatole. Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38[1].

HY-W007355S

Skatole-d3
Skatole-d₃ is the deuterium labeled Skatole. Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38[1].

HY-10405S

Pamapimod-d4

Pamapimod-d₄ (Ro4402257-d4) is the deuterium labeled Pamapimod. Pamapimod (Ro4402257) is a potent, selective and orally active p38 MAPK inhibitor with IC50s of 14 nM and 480 nM and Kis of 1.3 nM and 120 nM for p38α and p38β, respectively. Pamapimod has no activity against p38δ or p38γ isoforms. Pamapimod has the potential for rheumatoid arthritis and other autoimmune diseases treatment[1][2].

HY-N0168AS

(Rac)-Hesperetin-d3
(Rac)-Hesperetin-d₃ is the deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.

HY-N0168AS1

(Rac)-Hesperetin-13C,d3
(Rac)-Hesperetin- ¹³C,d₃ is the ¹³C- and deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.

HY-14188S

Amiodarone-d4 hydrochloride

Amiodarone-d₄ (hydrochloride) is the deuterium labeled Amiodarone hydrochloride. Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ∼45 nM[1]. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts[2]. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias[1].

Cat. No.	Product Name	Application	Reactivity

HY-P81156

phospho-ERK1 + 2 (Thr183/Tyr185) Antibody ERK1 + ERK2 (phospho Thr183/Tyr185); phospho-ERK1/MAPK-1/2(Thr183/Tyr185); ERK 1; ERK 2; ERK-2; ERK1; ERK2; ERT1; ERT2; Extracellular signal regulated kinase 1; Extracellular signal regulated kinase 1; Extracellular signal regulated kinase 2; Extracellular signal regulated kinase 2; Extracellular signal-regulated kinase 2; HS44KDAP; HUMKER1A; Insulin stimulated MAP2 kinase; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAP kinase isoform p44; MAPK 1; MAPK 2; MAPK1; MAPK2; MGC20180; Microtubule associated protein 2 kinase; Mitogen activated protein kinase 1; Mitogen activated protein kinase 1; Mitogen activated protein kinase 2; Mitogen-activated protein kinase 1; Mitogen-activated protein kinase 2; MK01_MOUSE; p38; p40; p41; p41mapk; p42 MAPK; p42-MAPK; p42MAPK; p42MAPK; p44 ERK1; p44 MAPK; p44ERK1; p44ERK1; p44MAPK; p44MAPK; PRKM 1; PRKM 1; PRKM 2; PRKM 2; PRKM1; PRKM2; Protein kinase mitogen activated 1; Protein kinase mitogen activated 1; Protein kinase mitogen activated 2; Protein kinase mitogen activated 2; Protein tyrosine kinas.	WB; ELISA; IHC-P; IHC-F; ICC; IF	Human, Mouse(predicted: Rat, Chicken, Dog, Cow, Horse, Rabbit, Guinea Pig)
phospho-ERK1 + 2 (Thr183/Tyr185) Antibody is an unconjugated, approximately 42/44 kDa, rabbit-derived, anti-phospho-ERK1 + 2 (Thr183/Tyr185) polyclonal antibody. phospho-ERK1 + 2 (Thr183/Tyr185) Antibody can be used for: WB, ELISA, IHC-P, IHC-F, ICC, IF expriments in human, mouse, and predicted: rat, chicken, dog, cow, horse, rabbit, guinea pig background without labeling.

HY-P82278

AHA1 Antibody (YA2023)

AHSA1; C14orf3; HSPC322; Activator of 90 kDa heat shock protein ATPase homolog 1; AHA1; p38
WB, IP Human, Mouse, Rat
HY-P81333

GRAP2 Antibody (YA1078)

p38; GADS; GRID; GRPL; GrbX; Mona; GRB2L; GRBLG; Grf40; GRAP-2
WB Human
HY-P81935

POLDIP2 Antibody (YA1680)

p38; POLD4; PDIp38
WB, IP Human

HY-P80996

p38 alpha/MAPK14 Antibody	WB, IF-Cell, IF-Tissue	Human, Mouse, Rat
p38 alpha/MAPK14 Antibody is an unconjugated, approximately 41 kDa, anti-p38 alpha/MAPK14 monoclonal antibody. p38 alpha/MAPK14 Antibody can be used for: WB, IF-Cell, IF-Tissue expriments in human, mouse, rat background without labeling.

HY-P80776A

*Phospho-p38* (Thr180+Tyr182) Antibody** p38 (phospho T180 + Y182); p-p38 (phospho T180 + Y182); p38 (phospho T180/Y182); CSAID Binding Protein 1; CSAID binding protein; CSAID-binding protein; Csaids binding protein; CSBP 1; CSBP 2; CSBP; CSBP1; CSBP2; CSPB 1; CSPB1; Cytokine suppressive anti inflammatory drug binding protein; Cytokine suppressive anti-inflammatory drug-binding protein; EXIP; MAP kinase 14; MAP kinase MXI2; MAP kinase p38 alpha; MAPK 14; MAPK14; MAX interacting protein 2; MAX-interacting protein 2; Mitogen Activated Protein Kinase 14; Mitogen activated protein kinase p38 alpha; Mitogen-activated protein kinase 14; Mitogen-activated protein kinase p38 alpha; MK14_HUMAN; Mxi 2; Mxi2; p38 ALPHA; p38; p38 MAP kinase; p38 MAPK; p38 mitogen activated protein kinase; p38ALPHA; p38alpha Exip; PRKM14; PRKM15; RK; SAPK 2A; SAPK2A; Stress Activated Protein Kinase 2A.	WB, IHC-P, Flow-Cyt, ICC, ELISA	Human, Mouse (predicted: Rat, Rabbit, Pig, Chicken, Dog, Horse)

HY-P80777

p38 Antibody MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein	WB, IP	Human
p38 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 41 kDa, targeting to p38. It can be used for WB,IP assays with tag free, in the background of Human.

HY-P80776

p38 Antibody (YA696) MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein	WB	Human, Mouse, Rat, Monkey
p38 Antibody (YA696) is a non-conjugated and Mouse origined monoclonal antibody about 41 kDa, targeting to p38 (5A1). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat, Monkey.

HY-P80907

Synaptophysin Antibody (YA664) SYP; Synaptophysin; Major synaptic vesicle protein p38	WB, IHC-P	Human, Mouse, Rat
Synaptophysin Antibody (YA664) is a non-conjugated and Mouse origined monoclonal antibody about 34 kDa, targeting to Synaptophysin (10C8). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P82764

EBP1 Antibody (YA2509)

PA2G4; EBP1; Proliferation-associated protein 2G4; Cell cycle protein p38-2G4 homolog; hG4-1; ErbB3-binding protein 1
WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

HY-P80842

*Phospho-p38* (Thr180/Tyr182) Antibody** MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein	WB	Human, Mouse, Rat
Phospho-p38 (Thr180/Tyr182) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 41 kDa, targeting to Phospho-p38 (Thr180/Tyr182). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

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