p50

Isoforms Recommended:	NF-κB1/p50

By Targets:	AP-1 (1) Apoptosis (2) Autophagy (1) c-Myc (1) Influenza Virus (1) Keap1-Nrf2 (1) MAP3K (1) NF-κB (5) p38 MAPK (1) Parasite (1) SARS-CoV (1)
By Research Areas:	Cancer (6) Infection (2) Inflammation/Immunology (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6046

Kamebakaurin	NF-κB	Inflammation/Immunology Cancer
Kamebakaurin is a natural compound isolated from Rabdosia excisa. Kamebakaurin is a potent inhibitor of NF-κB activation by directly targeting DNA-binding activity of p50 .

HY-N0191

Andrographolide 15+ Cited Publications Andrographis	NF-κB SARS-CoV Influenza Virus Autophagy Parasite	Infection Inflammation/Immunology Cancer
Andrographolide is a NF-κB inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on *p50* in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide has antiviral effects.

HY-N0290

Mangiferin 5+ Cited Publications	NF-κB Keap1-Nrf2 Apoptosis	Cancer
Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and *p50*. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities .

HY-149513

EP12	c-Myc Apoptosis	Cancer
EP12 is a c-Myc inhibitor. EP12 is a c-Myc G4 stabilizer. EP12 induces apoptosis and DNA damage in multiple myeloma cells. EP12 disrupts the nuclear translocation of P65/P50 by interfering with the NF-κB signaling pathway. EP12 inhibits multiple myeloma growth .

HY-N1140

Torilin	NF-κB AP-1 p38 MAPK MAP3K	Infection Inflammation/Immunology Cancer
Torilin is a sesquiterpene with antimicrobial, anticancer, and anti-inflammatory properties. Torilin inhibits LPS-induced NO release, as well as inhibiting iNOS, PGE2, COX-2, NF-α, IL-1β, IL-6, and GM-CSF. Torilin suppresses NF-kB and AP-1 translocation, inhibits TAK1 kinase activation. Subsequently results suppression of MAPK-mediated JNK, p38, ERK1/2, and AP-1 (ATF-2 and c-jun) activation and IKK-mediated I-κBα degradation, p65/p50 activation, and translocation .

HY-14645

(-)-DHMEQ Maximum Cited Publications 27 Publications Verification Dehydroxymethylepoxyquinomicin	NF-κB	Inflammation/Immunology Cancer
(-)-DHMEQ (Dehydroxymethylepoxyquinomicin) is a potent, selective and irreversible NF-κB inhibitor that covalently binds to a cysteine residue. (-)-DHMEQ inhibits nuclear translocation of NF-κB and shows anti-inflammatory and anticancer activity .

Cat. No.	Product Name

HY-L014

NF-κB Signaling Compound Library	798 compounds
Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. MCE owns a unique collection of 798 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

NF-κB Signaling Compound Library

798 compounds

Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.

MCE owns a unique collection of 798 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6046

Kamebakaurin	Classification of Application Fields Terpenoids Labiatae Diterpenoids Plants Baccharis densiflora Wedd. Inflammation/Immunology Disease Research Fields Cancer	NF-κB
Kamebakaurin is a natural compound isolated from Rabdosia excisa. Kamebakaurin is a potent inhibitor of NF-κB activation by directly targeting DNA-binding activity of p50 .

HY-N0191

Andrographolide 15+ Cited Publications Andrographis	Infection Andrographis paniculata (Burm. F.) Nees Classification of Application Fields Acanthaceae Terpenoids Source classification Diterpenoids Plants Inflammation/Immunology Disease Research Fields	NF-κB SARS-CoV Influenza Virus Autophagy Parasite
Andrographolide is a NF-κB inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on *p50* in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide has antiviral effects.

HY-N0290

Mangiferin 5+ Cited Publications	Structural Classification Liliaceae Xanthones Classification of Application Fields Source classification Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Disease Research Fields Cancer	NF-κB Keap1-Nrf2 Apoptosis
Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and *p50*. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities .

HY-N1140

Torilin	Source classification Torilis japonica (Houtt.) DC. Umbelliferae Plants	NF-κB AP-1 p38 MAPK MAP3K
Torilin is a sesquiterpene with antimicrobial, anticancer, and anti-inflammatory properties. Torilin inhibits LPS-induced NO release, as well as inhibiting iNOS, PGE2, COX-2, NF-α, IL-1β, IL-6, and GM-CSF. Torilin suppresses NF-kB and AP-1 translocation, inhibits TAK1 kinase activation. Subsequently results suppression of MAPK-mediated JNK, p38, ERK1/2, and AP-1 (ATF-2 and c-jun) activation and IKK-mediated I-κBα degradation, p65/p50 activation, and translocation .

Species:	Mouse (1) Cynomolgus (1)
Tag:	His (2)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P72724

	CD40 Protein, Mouse (174a.a, HEK293, His) Tumor necrosis factor receptor superfamily member 5; Bp50; CD40; TNFRSF5	Mouse	HEK293
	CD40 protein is a TNFSF5/CD40LG receptor that transduces signals through the TRAF6 and MAP3K8 pathways, activates ERK in macrophages and B cells, and induces immunoglobulin secretion. CD40 exists in monomeric and homodimeric forms, interacts with TRAF proteins (TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6) and crucially mediates cellular responses to external signals. CD40 Protein, Mouse (174a.a, HEK293, His) is the recombinant mouse-derived CD40 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD40 Protein, Mouse (174a.a, HEK293, His) is 174 a.a., with molecular weight of 21-25 kDa.

HY-P72725

	CD40 Protein, Cynomolgus (HEK293, His) Tumor necrosis factor receptor superfamily member 5; Bp50; CD40; TNFRSF5	Cynomolgus	HEK293
	CD40 Protein, a vital TNFR superfamily member, lacks conserved residue(s) crucial for feature annotation propagation, indicating unique structural attributes. This distinctiveness may influence CD40's functional interactions within the TNFR superfamily, underscoring the need for further exploration to unravel its specific roles and regulatory mechanisms in cellular signaling pathways. CD40 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD40 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD40 Protein, Cynomolgus (HEK293, His) is 173 a.a., with molecular weight of 28-30 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P81049

Phospho-NFKB1(Ser337) Antibody NFKB1; NF-KB; Nuclear factor NF-kappa-B p105 subunit; DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; Nuclear factor NF-kappa-B p50 subunit; NFkB p105 / p50; NFkB p105/p50; nuclear factor kappa B subunit 1; NF-kB; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1; NF-kappabeta	WB, IHC-P, IHC-F, Flow-Cyt, IF, ELISA	Human, Mouse (predicted: Rat, Pig, Cow)
Phospho-NFKB1 p105/p50 (Ser337) Antibody is an unconjugated, approximately 50&120 kDa, rabbit-derived, anti-NFKB1 p105/p50 (Ser337) polyclonal antibody. Phospho-NFKB1 p105/p50 (Ser337) Antibody can be used for: WB, IHC-P, ICC/IF expriments in human, mouse, rat background without labeling.

HY-P80244

*NF-κB p105/p50* Antibody**	WB, ICC, IHC-P	Human, Mouse
NF-κB p105/p50 Antibody is a non-conjugated and Mouse origined monoclonal antibody about 50 kDa, targeting to NF-κB p105/p50. It can be used for WB,ICC,IHC-P assays with tag free, in the background of Human, Mouse.

HY-P82703

Fibulin 5 Antibody (YA2448)

FBLN5; DANCE; Fibulin-5; FIBL-5; Developmental arteries and neural crest EGF-like protein; Dance; Urine p50 protein; Up50
WB Human, Mouse

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