Search Result

Isoforms Recommended:	RelA/p65

Results for "

p65

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Amyloid-β (1) AP-1 (1) Apoptosis (10) Autophagy (3) Bacterial (2) c-Myc (1) Caspase (2) COX (8) Endogenous Metabolite (6) ERK (4) Ferroptosis (3) GLUT (2) HDAC (1) HIV (1) HSV (2) IAP (1) IGF-1R (1) IKK (6) Influenza Virus (2) Interleukin Related (2) IRAK (2) Isotope-Labeled Compounds (1) Keap1-Nrf2 (2) MALT1 (1) MAP3K (1) MEK (1) Microtubule/Tubulin (1) Mitophagy (2) MMP (1) Na+/K+ ATPase (3) NF-κB (39) NO Synthase (3) NOD-like Receptor (NLR) (2) p38 MAPK (4) Parasite (2) PKC (1) PPAR (2) PROTACs (2) Reactive Oxygen Species (2) SARS-CoV (1) SHP2 (1) Sirtuin (2) STING (2) TGF-beta/Smad (1) TNF Receptor (3) Toll-like Receptor (TLR) (1) β-catenin (1)
By Research Areas:	Cancer (33) Cardiovascular Disease (4) Endocrinology (1) Infection (7) Inflammation/Immunology (46) Metabolic Disease (5) Neurological Disease (4)

By Targets:

Akt (1)

Amyloid-β (1)

AP-1 (1)

Apoptosis (10)

Autophagy (3)

Bacterial (2)

c-Myc (1)

Caspase (2)

COX (8)

Endogenous Metabolite (6)

ERK (4)

Ferroptosis (3)

GLUT (2)

HDAC (1)

HIV (1)

HSV (2)

IAP (1)

IGF-1R (1)

IKK (6)

Influenza Virus (2)

Interleukin Related (2)

IRAK (2)

Isotope-Labeled Compounds (1)

Keap1-Nrf2 (2)

MALT1 (1)

MAP3K (1)

MEK (1)

Microtubule/Tubulin (1)

Mitophagy (2)

MMP (1)

Na+/K+ ATPase (3)

NF-κB (39)

NO Synthase (3)

NOD-like Receptor (NLR) (2)

p38 MAPK (4)

Parasite (2)

PKC (1)

PPAR (2)

PROTACs (2)

Reactive Oxygen Species (2)

SARS-CoV (1)

SHP2 (1)

Sirtuin (2)

STING (2)

TGF-beta/Smad (1)

TNF Receptor (3)

Toll-like Receptor (TLR) (1)

β-catenin (1)

By Research Areas:

Cancer (33)

Cardiovascular Disease (4)

Endocrinology (1)

Infection (7)

Inflammation/Immunology (46)

Metabolic Disease (5)

Neurological Disease (4)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1832A

*PTD-p65-P1 Peptide TFA* 3 Publications Verification	NF-κB Apoptosis	Inflammation/Immunology Cancer
PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis .

HY-119970

Helenalin 4 Publications Verification	NF-κB	Inflammation/Immunology Cancer
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .

HY-N0629

Maslinic acid 5+ Cited Publications Crategolic acid; 2α-Hydroxyoleanolic acid	NF-κB Bacterial HIV Endogenous Metabolite	Inflammation/Immunology Cancer
Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation.

HY-P1832

*PTD-p65-P1 Peptide*	NF-κB Apoptosis	Inflammation/Immunology Cancer
PTD-p65-P1 Peptide is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis .

HY-120515

7-Oxostaurosporine	PKC	Cancer
7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that effectively inhibits tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway .

HY-147769

Anti-inflammatory agent 23	Others	Inflammation/Immunology
Anti-inflammatory agent 23 (Compound 4m) is an anti-inflammatory agent. Anti-inflammatory agent 23 inhibits the production of NO activated by LPS with an IC₅₀ of 0.449 μM. Anti-inflammatory agent 23 has a good affinity for p65 protein .

HY-N4187

Licochalcone D 1 Publications Verification	NF-κB Apoptosis Reactive Oxygen Species	Metabolic Disease Inflammation/Immunology Cancer
Licochalcone D, a flavonoid compound mainly existing in the root of Glycyrrhiza uralensis, is a potent and orally active inhibitor of NF-kappaB (NF-κB) p65. Licochalcone D possesses antioxidant, anti-inflammatory, anti-cancer properties .

HY-152089

SB26019	Microtubule/Tubulin	Neurological Disease Inflammation/Immunology
SB26019 is a potent anti-neuroinflammatory agent. SB26019 regulates NF-κB activation by inducing monomeric α-tubulin formation. SB26019-induced α-tubulin monomer inhibits p65 translocation .

HY-156398

Anti-inflammatory agent 60	NO Synthase β-catenin NF-κB	Inflammation/Immunology
Anti-inflammatory agent 60(compound 21) inhibitsnitric oxide production, with anIC₅₀value of 12.95 μM.Anti-inflammatory agent 60reducesiNOS,phosphorylated p65, andβ-cateninexpression in a concentration-dependent manner .

HY-N0694

Schisantherin A 1 Publications Verification Gomisin-C; Schizantherin-A; Wuweizi ester-A	NF-κB	Inflammation/Immunology
Schisantherin A is a dibenzocyclooctadiene lignan. Schisantherin A inhibits *p65-NF-κB* translocation into the nucleus by IκBα degradation.

HY-N1956

Rubiadin-1-methyl ether
Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65 .

HY-161329

NLRP3-IN-32	NOD-like Receptor (NLR) Reactive Oxygen Species NF-κB IKK	Inflammation/Immunology
NLRP3-IN-32 (compound 7a), a 3, 4-dihydronaphthalene-1(2H)-one derivative, is a potential NLRP3 inflammatory vesicles inhibitor. NLRP3-IN-32 can block the assembly and activation of NLRP3 inflammasome by down-regulating the expression of NLPR3 and apoptosis-associated speck-like protein containing a CARD (ASC), and inhibiting the production of reactive oxygen species (ROS) and other inflammatory mediators. NLRP3-IN-32 inhibits the phosphorylation of IκBα and NF-κB/p65 and the nuclear translocation of p65, thereby inhibiting NF-κB signaling .

HY-139833

Anti-inflammatory agent 6	NF-κB IKK	Inflammation/Immunology
Anti-inflammatory agent 6 blocks the phosphorylation of I kappa b kinase α/β (IKKα/β), IκBα, and nuclear factor kB p65 (NF-κB p65) which is a key controller of inflammation, thereby showing anti-inflammatory potential.

HY-D0162

Malachite green hemioxalate 1 Publications Verification	IKK NF-κB Apoptosis	Cancer
Malachite green hemioxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green hemioxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, *p65* and IRF3. Malachite green hemioxalate exhibits antitumor activity in vitro and in vivo .

HY-N1987

Cucurbitacin IIb
Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α .

HY-114981

SRTCX1002	Sirtuin	Inflammation/Immunology
SRTCX1002 is a potent activator of SIRT1 (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC₅₀s of 0.71 and 7.58 µM, respectively .

HY-10496

SC75741 10+ Cited Publications	NF-κB Influenza Virus	Infection Cancer
SC75741 is a broad and efficient NF-κB inhibitor with an IC₅₀ of 200 nM for *p65* . SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the NF-κB subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins .

HY-149724

Anti-inflammatory agent 65	STING NO Synthase	Inflammation/Immunology
Anti-inflammatory agent 65 (compound 29) is a Hederagonic acid derivative with potent anti-inflammatory activity. Anti-inflammatory agent 65 inhibits nitric oxide (NO) release. Anti-inflammatory agent 65 inhibits the nuclear translocation of IRF3 and p65, and disrupts the STING/IRF3/NF-κB signaling pathway, thereby attenuating the inflammatory response .

HY-157298

anti-TNBC agent-4	Apoptosis	Cancer
anti-TNBC agent-4 (compound 7) exhibits highly inhibitory activity against different TNBC cells with IC₅₀s from 0.37 μM to 1.52 μM. anti-TNBC agent-4 inhibits IKKβ mediated phosphorylation of IκB and *p65. anti-TNBC agent-4 induces TNBC cells apoptosis* .

HY-149652

IRF5-IN-1	Others	Inflammation/Immunology
IRF5-IN-1 (compound C5) is an IRF5 pathway-specific inhibitor. IRF5-IN-1 significantly reduces IRF5 nuclear translocation without affecting the activation of NF-κB p65. IRF5-IN-1 acts through SLC15A4 to selectively inhibit TLR7/8-induced IRF5 responses in cells .

HY-162170

Anti-inflammatory agent 72	NF-κB Keap1-Nrf2 p38 MAPK	Inflammation/Immunology
Anti-inflammatory agent 72 (compound 5) is a novel resveratrol derivative hybrid with benzoylhydrazine. Anti-inflammatory agent 72 shows anti-inflammatory and antioxidant activities by activating Nrf2 and inhibiting *NF-κB p65/iNOS and MAPKs* signaling pathways .

HY-N0191

Andrographolide 15+ Cited Publications Andrographis	NF-κB SARS-CoV Influenza Virus Autophagy Parasite	Infection Inflammation/Immunology Cancer
Andrographolide is a NF-κB inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide has antiviral effects.

HY-N0290

Mangiferin 5+ Cited Publications	NF-κB Keap1-Nrf2 Apoptosis	Cancer
Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits *p65* and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities .

HY-121896

DSHN	SHP2	Cancer
DSHN is a potent small heterodimer partner (SHP) activator. DSHN inhibits Ccl2 expression and secretion by inhibiting p65 activation of Ccl2 promoter activity. DSHN can be used in research of cancer .

HY-162092

Multi-target Pt	NF-κB IKK	Cancer
Multi-target Pt (IV), an antitumor agent, suppresses the IKKβ phosphorylation, IκBα phosphorylation and NF-κB p65 phosphorylation and nuclear translocation, leading to blocked the NF-kB signal pathway .

HY-149331

TNF-α-IN-11	TNF Receptor Caspase NF-κB	Inflammation/Immunology
TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor with a K_D value of 12.06 μM. TNF-α-IN-11 binds to TNF-α and blocks the activation of TNF-α-trigged caspase and NF-κB signaling pathway. TNF-α-IN-11 inhibits the phosphorylation of IκBα, as well as the nuclear translocation of NF κB p65. TNF-α-IN-11 can be used for research of TNF-α-mediated autoimmune diseases .

HY-N0001

(-)-Epicatechin 3 Publications Verification (-)-Epicatechol; Epicatechin; epi-Catechin	COX Ferroptosis Endogenous Metabolite	Inflammation/Immunology Cancer
(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-N6263

EGCG Octaacetate 1 Publications Verification AcEGCG; Peracetylated (-)-epigallocatechin-3-gallate	Bacterial	Infection Cardiovascular Disease Cancer
EGCG Octaacetate (AcEGCG) is a proagent of Green tea epigallocatechin-3-gallate (EGCG). EGCG Octaacetate decreases the proinflammatory mediator levels by down-regulating of PI3K/Akt/NFκB phosphorylation and p65 acetylation. EGCG Octaacetate reduces colitis-driven colon cancer in mice. EGCG octaacetate is the potential antibacterial compound for gram-positive bacteria (GPB) and gram-negative bacteria (GNB) .

HY-N0039

Ginsenoside Rb1 5 Publications Verification Gypenoside III	Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV	Inflammation/Immunology Cancer
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

HY-N12523

Chebulanin	NF-κB p38 MAPK	Inflammation/Immunology
Chebulanin, a polyphenol acid, exerts its anti-inflammatory and anti-arthritic effects via inhibiting NF-κB and MAPK activation in collagen-induced arthritis mice. Chebulanin inhibits the nuclear translocation of p38 and p65 in LPS-stimulated macrophages .

HY-149513

EP12	c-Myc Apoptosis	Cancer
EP12 is a c-Myc inhibitor. EP12 is a c-Myc G4 stabilizer. EP12 induces apoptosis and DNA damage in multiple myeloma cells. EP12 disrupts the nuclear translocation of P65/P50 by interfering with the NF-κB signaling pathway. EP12 inhibits multiple myeloma growth .

HY-N0222

Avicularin 3 Publications Verification	COX NF-κB PPAR ERK GLUT Apoptosis	Infection Neurological Disease Inflammation/Immunology Cancer
Avicularin is an orally active flavonoid. Avicularin inhibits NF-κB (p65), COX-2 and PPAR-γ activities. Avicularin has anti-inflammatory, anti-infectious anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities .

HY-100581

CORM-3
CORM-3, a carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces NLRP3 inflammasome activation .

HY-N9149

Cryptanoside A	Na+/K+ ATPase Akt NF-κB	Cardiovascular Disease Inflammation/Immunology Cancer
Cryptanoside A, a cardiac glycoside epoxide, can be isolated from the stems of Cryptolepis dubia. Cryptanoside A has potent cytotoxicity against cancer cells. Cryptanoside A also inhibits Na+/K+-ATPase activity. Cryptanoside A increases the expression of Akt and the p65 subunit of NF-κB .

HY-121471

Chrysoeriol 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
Chrysoeriol is a kind of natural yellow ash, which can be used for heating plants Coronopus didymus. Chrysoeriol suppresses the JAK2/STAT3, IκB/p65, and NF-κB pathways, and has strong anti-inflammatory activity.

HY-N3552

Catalposide	NF-κB	Inflammation/Immunology
Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages .

HY-N0613

Sauchinone 1 Publications Verification	NF-κB	Inflammation/Immunology
Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and *p65* nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity .

HY-N0722

Neochlorogenic acid 1 Publications Verification trans-5-O-Caffeoylquinic acid	NF-κB Interleukin Related TNF Receptor COX	Inflammation/Immunology Cancer
Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.

HY-125171

IAXO-102 4 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. IAXO-102 inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development .

HY-13982

JSH-23 Maximum Cited Publications 80 Publications Verification	NF-κB	Metabolic Disease Inflammation/Immunology Cancer
JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC₅₀ of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .

HY-N0001R

(-)-Epicatechin (Standard) (-)-Epicatechol(Standard); Epicatechin(Standard); epi-Catechin (Standard)	COX Ferroptosis Endogenous Metabolite	Inflammation/Immunology Cancer
(-)-Epicatechin (Standard) is the analytical standard of (-)-Epicatechin. This product is intended for research and analytical applications. (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-N6009

8-Deoxygartanin	Parasite NF-κB	Infection
8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE) . 8-Deoxygartanin exhibits antiplasmodial activity with an IC₅₀ of 11.8 μM for the W2 strain of Plasmodium falciparum . 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC₅₀ of 11.3 μM .

HY-N0222R

Avicularin (Standard)	COX NF-κB PPAR ERK GLUT Apoptosis	Infection Neurological Disease Inflammation/Immunology Cancer
Avicularin (Standard) is the analytical standard of Avicularin. This product is intended for research and analytical applications. Avicularin is an orally active flavonoid. Avicularin inhibits NF-κB (p65), COX-2 and PPAR-γ activities. Avicularin has anti-inflammatory, anti-infectious anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities .

HY-N0001S

(±)-Epicatechin-13C3	Isotope-Labeled Compounds COX Endogenous Metabolite Ferroptosis	Inflammation/Immunology Cancer
(±)-Epicatechin- ¹³C₃ is the ¹³C labeled (±)-Epicatechin. (-)-Epicatechin (HY-N0001) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB[1].

HY-N0039R

Ginsenoside Rb1 (Standard) Gypenoside III (Standard)	Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV	Inflammation/Immunology Cancer
Ginsenoside Rb1 (Standard) is the analytical standard of Ginsenoside Rb1. This product is intended for research and analytical applications. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

HY-N12604

Penicisteck acid F	NF-κB	Others
Penicisteck acid F (Compound 2) is a Marine derived tanzanic acid derivative that is a NF-κB inhibitor. Penicisteck acid F inhibits osteoclast expression by decreasing RANKL-induced IκBα degradation, NF-κB p65 nuclear translocation, NFATc1 activation and nuclear translocation, and related mRNA expression. Penicisteck acid F can be used in osteoporosis research .

HY-123984

LTβR-IN-1	NF-κB	Metabolic Disease
LTβR-IN-1 is a potent, selective lymphotoxin β receptor (LTβR) inhibitor. LTβR-IN-1 also selectively inhibits the nuclear translocation of p52 depended on TNF12A, instead of the nuclear translocation of p65 mediated by TNF-α receptor. LTβR-IN-1 regulates the NF-kB signaling pathway IN a ligand-independent manner .

HY-151966

TD1092	PROTACs IAP Caspase	Cancer
TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 activates Caspase 3/7, and promotes cancer cells apoptosis via IAP degradation. TD1092 inhibits TNFα mediated NF-κB pathway and reduces the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can act as PROTAC, and is used for cancer research .

HY-111172

Inotilone	MMP NF-κB	Cancer
Inotilone is an inhibitor of matrix metalloproteinase MMP-2 and MMP-9, to against metastatic in lung cancer cells. Inotilone enhances the activity of the antioxidant enzymes to support its anti-metastatic activity. Inotilone also inhibits IκBα phosphorylation and NFκB p65 nuclear translocation, involving in FAK, PI3K/AKT, MAPKs and NFκB pathways .

HY-N0908

Ginsenoside Rg5 1 Publications Verification	IGF-1R NF-κB COX	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Ginsenoside Rg5 is the main component of Red ginseng and IGF-1R agonist. Ginsenoside Rg5 compets for the binding site of IGF-1R and blocks the binding of IGF-1 to IGF-1R (IC₅₀ about 90 nM). Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65.

Cat. No.	Product Name

HY-L014

NF-κB Signaling Compound Library

798 compounds

Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.

MCE owns a unique collection of 798 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

Cat. No.	Product Name	Type

HY-D0162

Malachite green hemioxalate 1 Publications Verification	Fluorescent Dyes/Probes
Malachite green hemioxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green hemioxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, *p65* and IRF3. Malachite green hemioxalate exhibits antitumor activity in vitro and in vivo .

Cat. No.	Product Name	Target	Research Area

HY-P1832A

*PTD-p65-P1 Peptide TFA* 3 Publications Verification	NF-κB Apoptosis	Inflammation/Immunology Cancer
PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis .

HY-P1832

*PTD-p65-P1 Peptide*	NF-κB Apoptosis	Inflammation/Immunology Cancer
PTD-p65-P1 Peptide is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis .

HY-P4544

Val-Arg-Pro-DL-Arg-Fluoromethylketone	MALT1	Cancer
Val-Arg-Pro-DL-Arg-Fluoromethylketone is a potent MALT1 inhibitor. Val-Arg-Pro-DL-Arg-Fluoromethylketone inhibits cell proliferation and migration. Val-Arg-Pro-DL-Arg-Fluoromethylketone shows anticancer activity .

Species:	Virus (2) Human (2) Rat (1)
Tag:	His (5) SUMO (1)
Source:	E. coli Cell-free (3) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P702463

	SYT1/Synaptotagmin-1 Protein, Rat (Cell-Free, His) Synaptotagmin-1; Synaptotagmin I; SytI; p65	Rat	E. coli Cell-free
	Synaptotagmin-1 protein is a calcium sensor involved in neurotransmitter release and regulates synaptic vesicle transport. It binds acidic phospholipids and interacts with certain proteins, including neurotoxins, syntaxin, and AP2. SYT1/Synaptotagmin-1 Protein, Rat (Cell-Free, His) is the recombinant rat-derived SYT1/Synaptotagmin-1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SYT1/Synaptotagmin-1 Protein, Rat (Cell-Free, His) is 421 a.a., with molecular weight of 53.5 kDa.

HY-P702421

	Replicase 1AB polyprotein Protein, SARS-CoV (Cell-Free, His) Growth factor-like peptide; Leader protein; Non-structural protein 10; Non-structural protein 2; Non-structural protein 3; Non-structural protein 4; Non-structural protein 6; Non-structural protein 7; Non-structural protein 8; Non-structural protein 9; Papain-like proteinase; p65 homolog	Virus	E. coli Cell-free

HY-P71530

	PAK1 Protein, Human (His-SUMO) Serine/threonine-protein kinase PAK 1; Alpha-PAK; p21-activated kinase 1 ; p65-PAK; PAK1	Human	E. coli
	PAK1 is a dynamic protein kinase that plays an important role in multiple intracellular signaling pathways, affecting cytoskeletal dynamics, adhesion, migration, proliferation, apoptosis, mitosis, and vesicle trafficking. Multifunctional PAK1 directly phosphorylates BAD to provide antiapoptotic cell protection. PAK1 Protein, Human (His-SUMO) is the recombinant human-derived PAK1 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of PAK1 Protein, Human (His-SUMO) is 545 a.a., with molecular weight of ~76.6 kDa.

HY-P70128

	SARS-CoV-2 NSP2 Protein (His) r2019-nCoV NSP2, His; SARS-CoV 2 nsp2; SARS-CoV 2 p65 homolog	Virus	E. coli
	The ORF1ab gene is a specifically expressed gene of SARS-CoV-2 and can be quickly and sensitively detected to indirectly indicate the level of SARS-CoV-2. The ORF1ab protein is associated with viral replication and transcription, inhibition of host translation machinery, and suppression of host immune responses. SARS-CoV-2 NSP2 Protein (His) is the recombinant Virus-derived SARS-CoV-2 NSP2 protein, expressed by E. coli , with C-6*His labeled tag. The total length of SARS-CoV-2 NSP2 Protein (His) is 638 a.a., with molecular weight of ~80.0 kDa.

HY-P702387

	NOX1 Protein, Human (Cell-Free, His) NADPH oxidase 1; Mitogenic oxidase 1; MOX-1; NADH/NADPH mitogenic oxidase subunit p65-MOX; NOH-1	Human	E. coli Cell-free
	The NOX1 protein contains two isoforms with different functions. NOH-1S acts as a voltage-gated proton channel, manages H(+) currents in quiescent phagocytes and tissues, affects cellular pH, and is inhibited by zinc. NOX1 Protein, Human (Cell-Free, His) is the recombinant human-derived NOX1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of NOX1 Protein, Human (Cell-Free, His) is 564 a.a., with molecular weight of 67.7 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P80840

*Phospho-NF-KB p65* (Thr254) Antibody** NFKB3; RELA; TF65; Transcription factor p65; p65; NFkB	WB, IHC-P, ICC/IF	Human, Mouse, Rat
Phospho-NF-KB p65 (Thr254) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 60 kDa, targeting to Phospho-NF-KB p65 (Thr254). It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P80839

*Phospho-NF-KB p65* (Ser536) Antibody** NFKB3; RELA; TF65; Transcription factor p65; p65; NFkB	WB, IHC-P, ICC/IF	Human, Mouse, Rat
Phospho-NF-KB p65 (Ser536) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 60 kDa, targeting to Phospho-NF-KB p65 (Ser536). It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P80765

*NF-KB p65* Antibody** NFKB3; RELA; TF65; Transcription factor p65; p65; NFkB	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse
NF-KB p65 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 60 kDa, targeting to NF-KB p65. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse.

HY-P82468

WNK1 Antibody (YA2213) WNK1; HSN2; KDP; KIAA0344; PRKWNK1; Serine/threonine-protein kinase WNK1; Erythrocyte 65 kDa protein; p65; Kinase deficient protein; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; hWNK1	WB, IHC-P	Human, Mouse, Rat

HY-P81239

*Phospho-NF-κB p65* (Ser276) Antibody** NF-kB p65 (phospho S276); p-NF-kB p65 (phospho S276); RELA(phospho S276); NF kB p65; NF-kB p65; NF kB p65; NF-κBp65; p65 NF kappaB; p65 NFkB; RELA; Transcription Factor p65; v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)); V Rel Avian Reticuloendotheliosis Viral Oncogene Homolog A; v rel reticuloendotheliosis viral oncogene homolog A (avian); v-rel reticuloendotheliosis viral oncogene homolog A; p65NFKB; Avian reticuloendotheliosis viral (v rel) oncogene homolog A; MGC131774; NFKB 3; NFKB3; Nuclear Factor NF Kappa B p65 Subunit; Nuclear factor of kappa light polypeptide gene enhancer in B cells 3; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B Cells. NFκB-p65; NFκB p65; NF κB-p65; NFκBp65	ELISA; IHC-P; IHC-F; Flow-Cyt; ICC; IF;	Human, Mouse, Rat, (predicted: Dog, Pig, Cow, Horse, )

HY-P81238

*Phospho-NF-κB p65* (Ser536) Antibody** NF-kB p65 (phospho S536); p-NF-κB p65(Phospho-Ser536); RELA(phospho S536); NF kB p65; NF-kB p65; NFKBp65; NF-κBp65; p65 NF kappaB; p65 NFkB; NFKBp65; RELA; Transcription Factor p65; v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)); V Rel Avian Reticuloendotheliosis Viral Oncogene Homolog A; v rel reticuloendotheliosis viral oncogene homolog A (avian); v-rel reticuloendotheliosis viral oncogene homolog A; p65NFKB; Avian reticuloendotheliosis viral (v rel) oncogene homolog A; MGC131774; NFKB 3; NFKB3; Nuclear Factor NF Kappa B p65 Subunit; Nuclear factor of kappa light polypeptide gene enhancer in B cells 3; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B Cells; TF65_HUMAN. NFκB-p65; NFκB p65; NF κB-p65; NFκBp65	WB; IHC; Flow-Cyt;	Human, Mouse, Rat, (predicted: Chicken, Dog, Cow, Horse, )

HY-P81618

PAK1 Antibody (YA1363)

PAK1; Serine/threonine-protein kinase PAK 1; Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAK
WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

HY-P80245

*NF-κB p65* Antibody**	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
NF-κB p65 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 65 kDa, targeting to NF-κB p65. It can be used for WB,ICC/IF,IHC-P,IP,FC assays with tag free, in the background of Human, Mouse.

HY-P80470

*Phospho-NF-κB p65* (Ser529) Antibody**	WB, IP, FC, IHC-P	Human
Phospho-NF-κB p65 (Ser529) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 60 kDa, targeting to Phospho-NF-κB p65(S529). It can be used for WB,IP,FC,IHC-P assays with tag free, in the background of Human.

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