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pH3

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25

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3

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6

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1571
    Bromophenol blue

    		Environmental Pollutants Fluorescent Dye Others
    Bromophenol blue is an acid phthalein dye, and it is used as a tracking dye for electrophoresis. Bromophenol blue is also used as a pH indicator, with a transition range of pH 3 to 4.6. Bromophenol blue is used as a sensor for the determination of several compounds including ammonia, drugs, proteins and amino acids. The binding of Bromophenol blue to proteins is accompanied by the appearance of a strong absorbance at 610 nm .
    Bromophenol blue
  • HY-D0952
    Acridine Orange base
    35+ Cited Publications

    		 Parasite Others
    Acridine Orange base is a cell-permeable fluorescent dye that stains organisms (bacteria, parasites, viruses, etc.) bright orange and, when used under appropriate conditions (pH=3.5, Ex=460 nm), distinguishes human cells in green for detection by fluorescence microscopy. Acridine Orange base fluoresces green when bound to dsDNA (Ex=488, Em=520-524) and red when bound to ssDNA (Ex=457, Em=630-644) or ssRNA (Ex=457, Em=630-644), also can be used in cell cycle assays [3].
    Acridine Orange base
  • HY-W110798
    Bromophenol blue indicator (3.0-4.6)
    1 Publications Verification

    		 Environmental Pollutants Biochemical Assay Reagents Others
    Bromophenol blue indicator (3.0-4.6) is a synthetic dye commonly used as an acid-base indicator with a transition range of pH 3.0-4.6. Bromophenol blue indicator (3.0-4.6) is water soluble and changes color from yellow to blue as the pH of the solution changes from acidic to basic. Its unique chemical properties make it an important ingredient in a variety of scientific applications, especially in biochemistry and molecular biology. In addition, it can be used as a stain in microbiology and histology. However, Bromophenol blue indicator (3.0-4.6) has potential irritating and staining properties.
    Bromophenol blue indicator (3.0-4.6)
  • HY-168022
    CAM2602
    1 Publications Verification

    		 Aurora Kinase Cancer
    CAM2602 is an orally active Aurora A-TPX2 protein−protein interaction inhibitor with a human Kd of 19 nM for Aurora A. CAM2602 increases the proportion of PH3 positive cells while reducing P-T288 Aurora A levels. CAM2602 arrests tumor xenograft growth in mice. CAM2602 can be used for the research of cancer, such as acute T cell leukemia .
    CAM2602
  • HY-W243460
    EDTA copper(II) disodium salt, 97%

    		Biochemical Assay Reagents Others
    EDTA copper (II) disodium salt, 97% is a negatively charged copper (II)-ethylenediaminetetraacetic acid chelate and also an adsorption substrate. EDTA copper (II) disodium salt, 97% forms amide bonds with chitosan amino groups in weakly acidic (pH 3-5) solutions, while it forms the CuEDTA (OH) 3− hydroxyl complex in strongly alkaline (pH > 12) solutions. EDTA copper (II) disodium salt, 97% can be adsorbed onto granular activated carbon, with electrostatic interactions dominating its pH-dependent adsorption behavior. EDTA copper (II) disodium salt, 97% can be used to eliminate the inhibition of enzyme-catalyzed reactions caused by trace heavy metals .
    EDTA copper(II) disodium salt, 97%
  • HY-175216
    Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6

    		Drug-Linker Conjugates for ADC Topoisomerase Cancer
    Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6 is a drug-linker conjugate for ADC. Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6 consists of a topoisomerase 1 inhibitor (Topi MF-6) (HY-175203) and a cleavable linker (Maleimide-Ph(3,5-F)-PEG4-Val-Ala) (HY-175218). Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6 can be used for synthesis of ADCs .
    Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6
  • HY-W009311
    Thiomichler's ketone

    4,4'-Bis(dimethylamino)thiobenzopHenone

    		 Biochemical Assay Reagents Others
    Thiomichler's ketone (4,4'-Bis (dimethylamino) thiobenzophenone) is a heavy metal complexing agent and a colorimetric/spectrophotometric reagent. Thiomichler's ketone shows selectivity for Hg 2+ at pH 3, and exhibits activity towards Pd 2+ and Ag + at pH 3.5. Thiomichler's ketone enables accurate detection of trace Pd 2+ by forming an extractable Hg 2+ complex via micelle-mediated cloud point extraction, or generating a red coordination complex including Pd (TMK)4. Thiomichler's ketone is applicable for the determination of trace Pd 2+ in antibiotics and catalysts of automobile exhaust purifiers [3].
    Thiomichler's ketone
  • HY-142981
    Dioctadecylamine

    DODA

    		 Liposome Others
    Dioctadecylamine (DODA) is a secondary amine that has been shown to self-organize in plate-like structures in aqueous solution. Dioctadecylamine exhibits sufficiently hydrophobic properties of nanoparticles and good dispersibility in nonpolar solvent. Dioctadecylamine does not form a monolayer above pH 3.9 [3].
    Dioctadecylamine
  • HY-124348
    DM-PIT-1

    3,5-Dimethyl PIT-1

    		 PI3K Cancer
    DM-PIT-1 is a PIP3/PH (phosphatidylinositol-3,4,5-triphosphate/Pleckstrin) interaction inhibitor. DM-PIT-1 decreases he expression of P-Akt, P-GSK-3-β, P-p70S6K, P-S6, P-4E-BP1. DM-PIT-1 induces apoptosis and shows anticancer activity. DM-PIT-1 has the potential for the research of ovarian cancer .
    DM-PIT-1
  • HY-175218
    Maleimide-Ph(3,5-F)-PEG4-Val-Ala

    		ADC Linker Cancer
    Maleimide-Ph(3,5-F)-PEG4-Val-Ala is a cleavable PEG-based ADC linker that can be used in the synthesis of antibody-drug conjugates (ADCs) .
    Maleimide-Ph(3,5-F)-PEG4-Val-Ala
  • HY-173558
    PD-L1/HDAC3-IN-1

    		PD-1/PD-L1 HDAC Apoptosis Cancer
    PD-L1/HDAC3-IN-1 (PH3) is a dual PD-L1/HDAC3 Inhibitor with IC50 values of 89.4 nM and 107 nM for PD-1/PD-L1 and HDAC3, respectively. PD-L1/HDAC3-IN-1 induces cell apoptosis and arrests cell cycle at G0/G1 phase. PD-L1/HDAC3-IN-1 shows anticancer activity both in vivo and in vitro .
    PD-L1/HDAC3-IN-1
  • HY-W110789
    Ethyl Orange sodium, indicator grade

    		Biochemical Assay Reagents Others
    Ethyl Orange (sodium), indicator grade is an organic azo compound that can be used as a pH indicator from pH 3.0 to pH 4.8, changing color from red to orange.
    Ethyl Orange sodium, indicator grade
  • HY-D0011
    Brom0phenol blue sodium
    1 Publications Verification

    		 Biochemical Assay Reagents Others
    Bromophenol blue sodium is a pH indicator. It changes from yellow at pH 3.0 to blue at pH 4.6. Bromophenol blue sodium is also used as a tracking dye to monitor the process of agarose gel electrophoresis and polyacrylamide gel electrophoresis .
    Brom0phenol blue sodium
  • HY-Y0367R
    Maleic acid (Standard)

    		Reference Standards Endogenous Metabolite Bacterial Infection
    Maleic Acid (Standard) is the analytical standard of Maleic Acid. This product is intended for research and analytical applications. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes. IC50 & Target: GAD . In Vitro: The MICs of WT 10403S for the acids (e.g., Maleic Acid) are 34 mM, 25 mM, 31 mM and 30 mM which correspond to pH values prior to growth of 4.84, 5.14, 5.32 and 5.02 respectively. Of all compounds tested, Maleic Acid is the least inhibitory despite acting at a lower pH (4.84). The most acid resistant (10403S) and the weakest (EGD-e) strain are challenged with 8.6 mM and 4.3 mM of each organic acid at pH 3 and 3.3 respectively. On both strains, Maleic Acid is the most bactericidal .
    Maleic acid (Standard)
  • HY-179665
    0.1M Acetate Buffer, pH 3.6

    		Biochemical Assay Reagents Others
    0.1M Acetate Buffer, pH 3.6 is an acetate buffer with a concentration of 0.1 M and a pH of 3.6.
    0.1M Acetate Buffer, pH 3.6
  • HY-W096118
    m-PEG2-O-Ph-3-NH2

    		PROTAC Linkers Cancer
    m-PEG2-O-Ph-3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    m-PEG2-O-Ph-3-NH2
  • HY-14878
    (2R)-Atecegatran

    (2R)-AZD-0837

    		 Thrombin Cardiovascular Disease
    (2R)-Atecegatran ((2R)-AZD-0837; (Ph(3-Cl)(5-OCHF2)-(R)CH(OH)C(O)-Aze-Pab)) is a thrombin inhibitor. (2R)-Atecegatran can be used in research related to thromboembolic disorders .
    (2R)-Atecegatran
  • HY-155754
    3′-Acetate-ATP

    		ATP Synthase Others
    3’-Acetate-ATP, an ATP analogue, is ATP acetylation product with an maxima uv absorption at 259 nm in water at neutral pH. 3’-Acetate-ATP exerts a blocking effect on nucleic acid polymerization .
    3′-Acetate-ATP
  • HY-125066
    Reveromycin B

    		Bacterial Infection
    Reveromycin B is a spiroketal bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells (IC50=6 μg/mL) and exhibits pH-dependent antifungal activity against C. albicans (MICs=15.6 and >500 μg/mL at pH 3.0 and 7.4, respectively). Unlike reveromycin A and reveromycin C, reveromycin B does not inhibit proliferation of KB and K562 cells.
    Reveromycin B
  • HY-W747507
    Reveromycin D

    		Bacterial Infection
    Reveromycin D is a bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells and has pH-dependent antifungal activity against C. albicans (MICs=2 and >500 μg/mL at pH 3 and 7.4, respectively).2 Reveromycin D also inhibits proliferation of KB and K562 cells (IC50s=1.6 and 1.3 μg/mL, respectively).
    Reveromycin D
  • HY-125322
    Reveromycin C

    		Bacterial Infection
    Reveromycin C is a polyketide originally isolated from Streptomyces that has antifungal activity against C. albicans (MICs=2.0 and >500 μg/mL at pH 3 and 7.4, respectively). Reveromycin C inhibits EGF-induced mitogenic activity in the Balb/MK mouse epidermal cell line. It also reverses the morphology of sarcoma-virus-transformed NRK rat kidney cells (EC50=1.58 μg/mL) and inhibits proliferation of KB cells and K562 human chronic myelogenous leukemia cells (IC50=2.0 μg/mL for both).
    Reveromycin C
  • HY-131586
    3,7-Dihydroxyflavone

    Resogalangin

    		 17β-HSD Estrogen Receptor/ERR Aldose Reductase Endocrinology Cancer
    3,7-Dihydroxyflavone (Resogalangin) is a flavonoid phytoestrogen, which can be isolated from Adenophora species. 3,7-Dihydroxyflavone is a modulator of estrogen receptors and an inhibitor of human progesterone metabolizing enzyme AKR1C1 and fungal 17β-hydroxysteroid dehydrogenase and a redox inhibitor (IC50=0.6 and 6.0 μM, respectively). 3,7-Dihydroxyflavone is a fluorescent binding substrate for human serum albumin (HSA) with excitation wavelengths of 370 nm (pH 7.4) and 350 nm (pH 3.5), respectively, and emission wavelength of 515 nm .
    3,7-Dihydroxyflavone
  • HY-181078
    Cephalotaxine-ester-(R)-1-ethoxy-3-mercaptopropan-2-ol-Ph(3,4OMe)

    		c-Myc Apoptosis Bcl-2 Family Cancer
    Cephalotaxine-ester-(R)-1-ethoxy-3-mercaptopropan-2-ol-Ph (3,4OMe) is an anti-leukemic agent with potent ribosome-targeting protein synthesis inhibition. Cephalotaxine-ester-(R)-1-ethoxy-3-mercaptopropan-2-ol-Ph (3,4OMe) downregulates short-lived oncoproteins, including c-Myc and Mcl-1, by inhibiting protein synthesis. Cephalotaxine-ester-(R)-1-ethoxy-3-mercaptopropan-2-ol-Ph (3,4OMe) induces cell cycle arrest at the G0/G1 phase and triggers mitochondrial pathway-mediated apoptosis in acute myeloid leukemia (AML) cells. Cephalotaxine-ester-(R)-1-ethoxy-3-mercaptopropan-2-ol-Ph (3,4OMe) is applicable for research on leukemia .
    Cephalotaxine-ester-(R)-1-ethoxy-3-mercaptopropan-2-ol-Ph(3,4OMe)
  • HY-W800770
    MB 543 DBCO

    		Fluorescent Dye Others
    MB 543 DBCO is a fluroescent agent with a terminal DBCO group. The DBCO group is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. MB 543 Alkyne is a very hydrophilic, water-soluble, orange fluorescent dye that has a maximal absorption of 543 nm and emission at 566 nm. The compound is also pH insensitive from pH 3 to pH 10.
    MB 543 DBCO
  • HY-171946
    TGA-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT

    		Drug-Linker Conjugates for ADC Topoisomerase Cancer
    TGA-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT is a drug-linker conjugate for ADC. TGA-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT consists of a topoisomerase 1 inhibitor (Topi MF-6) (HY-175203) and a cleavable linker (Maleimide-Ph(3,5-F)-PEG4-Val-Ala) (HY-175218). TGA-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT can be used for synthesis of ADCs .
    TGA-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT

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