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Results for "

pantothenate kinase

" in MCE Product Catalog:
Cat. No. Product Name Target Research Areas
  • HY-144734
    Pantothenate kinase-IN-1

    Others Neurological Disease
    Pantothenate kinase-IN-1 (Compound 1) is a pantothenate kinase (PANK) modulator with an IC50 of 0.51 µM against PANK3. Pantothenate kinase-IN-1 has a reasonable ligand efficiency (LipE = 2.8).
  • HY-124634

    Others Neurological Disease
    PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively.
  • HY-109033


    Neurological Disease
    Fosmetpantotenate is a phosphopantothenic acid (PPA) prodrug designed to release PPA intracellularly, leading to restoration of CoA levels. Fosmetpantotenate is used to treat pantothenate kinase-associated neurodegeneration.