peptidoglycan

By Targets:	Antibiotic (6) Bacterial (14) Endogenous Metabolite (2) Fluorescent Dye (6) Glycosyltransferase (1) iGluR (2) NOD-like Receptor (NLR) (1) p38 MAPK (1) Penicillin-binding protein (PBP) (3)
By Research Areas:	Cancer (3) Infection (19) Inflammation/Immunology (1) Neurological Disease (2)
Click Chemistry:	Labeling and Fluorescence Imaging (1) Azide (2) Alkynes (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131045

HADA hydrochloride 1 Publications Verification HCC-Amino-D-alanine hydrochloride	Bacterial	Infection
HADA hydrochloride (HCC-Amino-D-alanine hydrochloride) is a blue (λ_em~450 nm) fluorescent D-amino acid (FDAA). FDAAs are efficiently incorporated into the peptidoglycans (PGs) of diverse bacterial species at the sites of PG biosynthesis, allowing specific and covalent probing of bacterial growth with minimal perturbation .

HY-W015450

D-Ala-D-Ala	Endogenous Metabolite	Others
D-Ala-D-Ala constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala is catalyzed by D-Alanine-D-Alanine ligase. D-Ala-D-Ala is a bacterial endogenous metabolite .

HY-B0030

D-Cycloserine 3 Publications Verification	iGluR Bacterial Antibiotic	Infection Neurological Disease Cancer
D-Cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes. D-Cycloserine is a partial NMDA agonist that can improve cognitive functions. D-Cycloserine can be used for multidrug-resistant tuberculosis research .

HY-150063

Antibacterial agent 116	Penicillin-binding protein (PBP) Bacterial	Infection
Antibacterial agent 116 is a benzophenone-containing salicylanilide compound. Antibacterial agent 116 has potent antibacterial activity by inhibiting the peptidoglycan formation. Antibacterial agent 116 is used as a photoaffinity probe to label Acinetobacter baumannii penicillin-binding protein (PBP1b), block the propagation pathway to disrupt the growth of peptidoglycan chain .

HY-P1068A

Recombinant human lysozyme (plant expression)	Bacterial	Infection
Recombinant human lysozyme (plant expression) is a conserved anti-bacterial protein that causes bacterial lysis and death by hydrolyzing bacterial cell wall peptidoglycan (PG). Recombinant human lysozyme (plant expression) can be used to study bacterial infections .

HY-147097

EDA-DA	Bacterial	Infection
EDA-DA, a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. Peptidoglycan (PG), an essential structure in the cell walls of the vast majority of bacteria, is critical for division and maintaining cell shape and hydrostatic pressure . EDA-DA is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-161239

(S)-IB-96212	Bacterial Antibiotic	Infection
(S)-IB-96212 (compound 4), an oligomycin derivative, inhibits the MurD2 reaction, but not the MurL reaction. (S)-IB-96212 is a specific inhibitor of the alternative pathway of peptidoglycan biosynthesis. (S)-IB-96212 weakly inhibits the MurD reaction .

HY-N4117

Hamamelitannin	Bacterial	Infection
Hamamelitannin, a polyphenol extracted from the bark of Hamamelis virginiana, is a quorum-sensing (QS) inhibitor. Hamamelitannin increases antibiotic susceptibility of staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release .

HY-D1690A

sBADA	Fluorescent Dye	Others
sBADA is a potent green fluorescent dye. sBADA is a sulfonated BODIPY-FL 3-amino-D-alanine. sBADA is used to label peptidoglycans in bacterial cell walls in situ. (λ_ex=490 nm, λ_em=510 nm) .

HY-124712

Divin	Bacterial	Infection
Divin, a potent chelator of iron, is a potent inhibitor of bacterial cell division with bacteriostatic effect in Gram-negative and Gram-positive bacteria. Divin disrupts the assembly of late division proteins, reduces peptidoglycan remodeling at the division site, and blocks compartmentalization of the cytoplasm .

HY-D1690

sBADA TFA	Fluorescent Dye	Others
sBADA TFA is a potent green fluorescent dye. sBADA TFA is a sulfonated BODIPY-FL 3-amino-D-alanine. sBADA TFA is used to label peptidoglycans in bacterial cell walls in situ. (λ_ex=490 nm, λ_em=510 nm) .

HY-147097A

EDA-DA TFA	Bacterial	Infection
EDA-DA is a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. EDA-DA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .

HY-D1117

NADA-green NADA hydrochloride	Fluorescent Dye	Infection
NADA-green is a fluorescent D-amino acid probe. NADA-green is efficiently incorporated into the peptidoglycan of diverse bacterial species peptidoglycan biosynthesis. NADA-green allows probing of bacterial growth with minimal perturbation .

HY-B1596

Ceftizoxime 1 Publications Verification
Ceftizoxime is a bacterial inhibitor which acts by interfering with bacterial cell wall synthesis and inhibiting cross-linking of the peptidoglycan.

HY-D1697

OGDA

Fluorescent Dye Infection

OGDA is a green fluorescent D-amino acid. OGDA is suitable for labeling peptidoglycan in Gram-positive and Gram-negative bacteria .

OGDA	Fluorescent Dye	Infection
OGDA is a green fluorescent D-amino acid. OGDA is suitable for labeling peptidoglycan in Gram-positive and Gram-negative bacteria .

HY-154871

α-D-Glucosamine 1-phosphate	Endogenous Metabolite	Others
α-D-Glucosamine 1-phosphate is an E.coli metabolite. α-D-Glucosamine 1-phosphate is one of the precursors of peptidoglycan synthesis .

HY-B0974

Methicillin sodium salt 4 Publications Verification Meticillin sodium	Penicillin-binding protein (PBP) Bacterial Antibiotic	Infection
Methicillin sodium salt (Meticillin sodium) is a β-lactam, semi-synthetic antibiotic related to penicillin antibiotic. Methicillin sodium salt inhibits penicillin-binding proteins involved in the synthesis of peptidoglycan. Methicillin sodium salt inhibits S. aureus with a MIC value of 2.1 μg/mL. Methicillin sodium salt can be used for the research of inflammation .

HY-N7101

Cefpodoxime Proxetil U-76,252; CS-807	Bacterial Antibiotic Penicillin-binding protein (PBP)	Infection
Cefpodoxime proxetil is an orally administered broad spectrum third-generation cephalosporin. Cefpodoxime proxetil has anti-bacterial activity. Cefpodoxime proxetil binds to penicillin binding proteins (PBPs) which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis .

HY-163399

Antibacterial agent 197	Bacterial	Infection
Antibacterial agent 197 (compound 1-deAA) is a termination inhibitor of non-classical anhydroglycosyl receptors and anhydrowall peptide-type peptidoglycan (PG) in bacterial TGase, with activity against Staphylococcus aureus. Antibacterial agent 197 synergizes with Vancomycin (HY-B0671) and is its antibacterial adjuvant .

HY-P3078

Amphomycin	Bacterial Antibiotic	Infection
Amphomycin is a lipopeptide antibiotic that inhibits peptidoglycan synthesis and blocks cell wall development. Amphomycin exhibits potent antibacterial activities against methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE), penicillin-gentamicin-erythromycin-resistant S. pneumonia, and linezolid-quinupristin-dalfopristin-resistant enterococci .

HY-B0030R

D-Cycloserine (Standard)	iGluR Bacterial Antibiotic	Infection Neurological Disease Cancer
D-Cycloserine (Standard) is the analytical standard of D-Cycloserine. This product is intended for research and analytical applications. D-Cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes. D-Cycloserine is a partial NMDA agonist that can improve cognitive functions. D-Cycloserine can be used for multidrug-resistant tuberculosis research .

HY-147960

Glycosyltransferase-IN-1	Glycosyltransferase	Infection
Glycosyltransferase-IN-1 (compound 5m) is a potent glycosyltransferase inhibitor, with an IC₅₀ of 82.8 μM. Glycosyltransferase-IN-1 shows antibacterial activity, with MIC values of 6 μg/mL for MSSA, MRSA, B. subtilis and 12 μg/mL for E. coli .

HY-D1189

YADA Lucifer Yellow 3-amino-D-alanine	Fluorescent Dye	Others
YADA (Lucifer Yellow 3-amino-D-alanine) is a conjugate of the fluorescent dyes Lucifer yellow and D-alanine, which is a green-yellow fluorescent dye. YADA is suitable for labeling peptidoglycans in living bacteria that can be incorporated into the cell wall where they are being synthesized. YADA has a large Stokes shift and a wide emission spectrum, allowing excitation through a purple light source and detection using a green filter. YADA showed good water solubility, light stability and thermal stability.

HY-127090

Muramyl dipeptide 2 Publications Verification MDP	p38 MAPK NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is a NLRP1 agonist .

HY-D1274A

Sulfo-cyanine3 azide sodium	Fluorescent Dye	Others
Sulfo-cyanine3 azide sodium a water-soluble azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). Sulfo-cyanine3 azide sodium can be involved in synthesis of fused tricyclic heterocycles, produces immunostimulatory agents .

Cat. No.	Product Name	Type

HY-131045

HADA hydrochloride 1 Publications Verification HCC-Amino-D-alanine hydrochloride	Dyes
HADA hydrochloride (HCC-Amino-D-alanine hydrochloride) is a blue (λ_em~450 nm) fluorescent D-amino acid (FDAA). FDAAs are efficiently incorporated into the peptidoglycans (PGs) of diverse bacterial species at the sites of PG biosynthesis, allowing specific and covalent probing of bacterial growth with minimal perturbation .

HY-D1117

NADA-green NADA hydrochloride	Fluorescent Dyes/Probes
NADA-green is a fluorescent D-amino acid probe. NADA-green is efficiently incorporated into the peptidoglycan of diverse bacterial species peptidoglycan biosynthesis. NADA-green allows probing of bacterial growth with minimal perturbation .

HY-D1690

sBADA TFA	Fluorescent Dyes/Probes
sBADA TFA is a potent green fluorescent dye. sBADA TFA is a sulfonated BODIPY-FL 3-amino-D-alanine. sBADA TFA is used to label peptidoglycans in bacterial cell walls in situ. (λ_ex=490 nm, λ_em=510 nm) .

HY-D1189

YADA Lucifer Yellow 3-amino-D-alanine	Fluorescent Dyes/Probes
YADA (Lucifer Yellow 3-amino-D-alanine) is a conjugate of the fluorescent dyes Lucifer yellow and D-alanine, which is a green-yellow fluorescent dye. YADA is suitable for labeling peptidoglycans in living bacteria that can be incorporated into the cell wall where they are being synthesized. YADA has a large Stokes shift and a wide emission spectrum, allowing excitation through a purple light source and detection using a green filter. YADA showed good water solubility, light stability and thermal stability.

YADA

Lucifer Yellow 3-amino-D-alanine

Fluorescent Dyes/Probes

YADA (Lucifer Yellow 3-amino-D-alanine) is a conjugate of the fluorescent dyes Lucifer yellow and D-alanine, which is a green-yellow fluorescent dye. YADA is suitable for labeling peptidoglycans in living bacteria that can be incorporated into the cell wall where they are being synthesized. YADA has a large Stokes shift and a wide emission spectrum, allowing excitation through a purple light source and detection using a green filter. YADA showed good water solubility, light stability and thermal stability.

HY-D1274A

Sulfo-cyanine3 azide sodium	Fluorescent Dyes/Probes
Sulfo-cyanine3 azide sodium a water-soluble azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). Sulfo-cyanine3 azide sodium can be involved in synthesis of fused tricyclic heterocycles, produces immunostimulatory agents .

Cat. No.	Product Name	Target	Research Area

HY-W015450

D-Ala-D-Ala	Endogenous Metabolite	Others
D-Ala-D-Ala constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala is catalyzed by D-Alanine-D-Alanine ligase. D-Ala-D-Ala is a bacterial endogenous metabolite .

HY-W141916

Pentaglycine Tetraglycylglycine; Gly-Gly-Gly-Gly-Gly; NSC 96353	Peptides	Infection
Pentaglycine (Tetraglycylglycine) is a bridge containing five glycine molecules. Pentaglycine can form highly cross-linked peptidoglycan. Glucose reduced expression of pentaglycine. Pentaglycine is cleaved by lysostaphin, and occurs in the cell envelope of staphylococci .

HY-P5919

Ala-D-γ-Glu-Lys-D-Ala-D-Ala

Peptides Others

Ala-D-γ-Glu-Lys-D-Ala-D-Ala is the pentapeptide tail of the peptidoglycan precursor UDPMurNAc-l-Ala-γ-d-Glu-l-Lys(Gly)(5)-d-Ala-d-Ala .

Ala-D-γ-Glu-Lys-D-Ala-D-Ala	Peptides	Others
Ala-D-γ-Glu-Lys-D-Ala-D-Ala is the pentapeptide tail of the peptidoglycan precursor UDPMurNAc-l-Ala-γ-d-Glu-l-Lys(Gly)(5)-d-Ala-d-Ala .

HY-P3078

Amphomycin	Bacterial Antibiotic	Infection
Amphomycin is a lipopeptide antibiotic that inhibits peptidoglycan synthesis and blocks cell wall development. Amphomycin exhibits potent antibacterial activities against methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE), penicillin-gentamicin-erythromycin-resistant S. pneumonia, and linezolid-quinupristin-dalfopristin-resistant enterococci .

HY-P5481

DABCYL-LPETG-EDANS	Peptides	Others
DABCYL-LPETG-EDANS is a biological active peptide. (This 5-amino acid peptide is a sortase substrate, C-terminal sorting signal. Sortase cleaves surface proteins at the LPXTG motif and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Sortases are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer. Cleavage of this FRET substrate by sortase reveals the fluorescent signal, Abs/Em = 340/490 nm.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W015450

D-Ala-D-Ala	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
D-Ala-D-Ala constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala is catalyzed by D-Alanine-D-Alanine ligase. D-Ala-D-Ala is a bacterial endogenous metabolite .

HY-B0030

D-Cycloserine 3 Publications Verification	Structural Classification Microorganisms Antibiotics Resistance Selection Source classification Antibacterial Disease Research Other Antibiotics	iGluR Bacterial Antibiotic
D-Cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes. D-Cycloserine is a partial NMDA agonist that can improve cognitive functions. D-Cycloserine can be used for multidrug-resistant tuberculosis research .

HY-N4117

Hamamelitannin	Infection Hamamelis mollis Oliver Classification of Application Fields Source classification Phenols Polyphenols Hamamelidaceae Plants Disease Research Fields	Bacterial
Hamamelitannin, a polyphenol extracted from the bark of Hamamelis virginiana, is a quorum-sensing (QS) inhibitor. Hamamelitannin increases antibiotic susceptibility of staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release .

HY-154871

α-D-Glucosamine 1-phosphate	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
α-D-Glucosamine 1-phosphate is an E.coli metabolite. α-D-Glucosamine 1-phosphate is one of the precursors of peptidoglycan synthesis .

HY-B0030R

D-Cycloserine (Standard)	Infection Structural Classification Microorganisms Neurological Disease Classification of Application Fields Antibiotics Source classification Endogenous metabolite Disease Research Fields Beta-lactam Antibiotics	iGluR Bacterial Antibiotic
D-Cycloserine (Standard) is the analytical standard of D-Cycloserine. This product is intended for research and analytical applications. D-Cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes. D-Cycloserine is a partial NMDA agonist that can improve cognitive functions. D-Cycloserine can be used for multidrug-resistant tuberculosis research .

Species:	Human (1) Mouse (1)
Tag:	SUMO (1) His (4) Tag Free (1)
Source:	HEK293 (2) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P71467

	Pal Protein, Legionella pneumophila (His-SUMO) pal; pplA; peptidoglycan-associated lipoprotein; PAL; 19kDa surface antigen; PPL	Others	E. coli
	Pal protein, part of the Tol-Pal system, is pivotal in outer membrane invagination and maintenance of integrity during cell division. Integrated with TolA, TolQ, TolR, and TolB, the system connects inner and outer membranes to the peptidoglycan layer. Pal's strong association with peptidoglycan underscores its crucial role in the structural and functional dynamics of the Tol-Pal system. Pal Protein, Legionella pneumophila (His-SUMO) is the recombinant Pal protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of Pal Protein, Legionella pneumophila (His-SUMO) is 155 a.a., with molecular weight (affected by relative charge) of ~36 kDa.

HY-P77137

	PGLYRP4/PGRP-I beta Protein, Human (HEK293, His) peptidoglycan recognition protein 4; PGRP-I-beta; PGRPIB; SBBI67	Human	HEK293
	PGLYRP4/PGRP-I beta protein is a model receptor that binds to the cell wall peptide peptidoglycan (PGN) in Gram-positive bacteria and exerts bactericidal activity by interfering with peptidoglycan biosynthesis. Its antimicrobial properties extend to Gram-negative bacteria, although it also binds to them. PGLYRP4/PGRP-I beta Protein, Human (HEK293, His) is the recombinant human-derived PGLYRP4/PGRP-I beta protein, expressed by HEK293 , with C-His labeled tag. The total length of PGLYRP4/PGRP-I beta Protein, Human (HEK293, His) is 356 a.a., with molecular weight of ~40.2 KDa.

HY-P76543

	PGLYRP1/PGRP-S Protein, Mouse (HEK293, His) peptidoglycan recognition protein 1; Cytokine tag7; PGRP-S; Tag7; PGRP	Mouse	HEK293
	PGLYRP1/PGRP-S Protein plays a vital role in the innate immune response. It recognizes bacterial peptidoglycan and activates antimicrobial defense mechanisms. PGLYRP1/PGRP-S Protein interacts with other immune molecules, enhancing immune responses against bacterial infections. Understanding its functions can aid in developing strategies to combat bacterial pathogens. PGLYRP1/PGRP-S Protein, Mouse (HEK293, His) is the recombinant mouse-derived PGLYRP1/PGRP-S protein, expressed by HEK293 , with C-His labeled tag. The total length of PGLYRP1/PGRP-S Protein, Mouse (HEK293, His) is 164 a.a., with molecular weight of 18-21 kDa.

HY-P701958

	PBP1A Protein, Mycobacterium tuberculosis ponA1; Penicillin-binding protein 1A; PBP-1A; Penicillin-binding protein 1; Penicillin-insensitive transglycosylase; peptidoglycan* TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase	Others	E. coli
	PBP1A (penicillin-binding protein 1A) is involved in cell wall formation and plays a crucial role in the synthesis of cross-linked peptidoglycan from lipid intermediates. The enzyme has a bifunctional structure. The penicillin-insensitive transglycosylase N-terminal domain is responsible for the formation of linear glycan chains, and the penicillin-sensitive transpeptidase C-terminal domain promotes the cross-linking of peptide subunits. PBP1A Protein, Mycobacterium tuberculosis is the recombinant PBP1A protein, expressed by E. coli , with tag free. The total length of PBP1A Protein, Mycobacterium tuberculosis is 430 a.a., .

HY-P701959

	PBP1A Protein, Mycobacterium tuberculosis (His) ponA1; Penicillin-binding protein 1A; PBP-1A; Penicillin-binding protein 1; Penicillin-insensitive transglycosylase; peptidoglycan* TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase	Others	E. coli
	PBP1A (penicillin-binding protein 1A) is involved in cell wall formation and plays a crucial role in the synthesis of cross-linked peptidoglycan from lipid intermediates. The enzyme has a bifunctional structure. The penicillin-insensitive transglycosylase N-terminal domain is responsible for the formation of linear glycan chains, and the penicillin-sensitive transpeptidase C-terminal domain promotes the cross-linking of peptide subunits. PBP1A Protein, Mycobacterium tuberculosis (His) is the recombinant PBP1A protein, expressed by E. coli , with N-6*His labeled tag. The total length of PBP1A Protein, Mycobacterium tuberculosis (His) is 430 a.a., .

Cat. No.	Product Name		Classification

HY-157573

N-Acetylmuramic acid-azide		Azide
N-Acetylmuramic acid-azide (Compound 2) is a derivative of N-acetylaminoacetic acid (NAM) in bacterial peptidoglycan. Incorporated into bacterial peptidoglycan during biosynthesis .

HY-147097

EDA-DA		Alkynes
EDA-DA, a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. Peptidoglycan (PG), an essential structure in the cell walls of the vast majority of bacteria, is critical for division and maintaining cell shape and hydrostatic pressure . EDA-DA is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-147097A

EDA-DA TFA		Alkynes
EDA-DA is a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. EDA-DA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .

HY-D1274A

Sulfo-cyanine3 azide sodium		Labeling and Fluorescence Imaging Azide
Sulfo-cyanine3 azide sodium a water-soluble azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). Sulfo-cyanine3 azide sodium can be involved in synthesis of fused tricyclic heterocycles, produces immunostimulatory agents .


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Click Chemistry

peptidoglycan

Inhibitors & Agonists

Fluorescent Dye

Peptides

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Recombinant Proteins

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