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Results for "

phosphate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) ADC Cytotoxin (3) Antibiotic (4) Apoptosis (2) Bacterial (6) Biochemical Assay Reagents (3) Bradykinin Receptor (1) Calcium Channel (2) Calmodulin (1) Endogenous Metabolite (11) Epigenetic Reader Domain (1) GSK-3 (2) IKK (1) MEK (1) Myosin (1) Na+/H+ Exchanger (NHE) (2) NF-κB (1) P2Y Receptor (1) Phosphatase (2) Phosphodiesterase (PDE) (1) Potassium Channel (1) Prostaglandin Receptor (1) Protease Activated Receptor (PAR) (1) Ras (3) Reactive Oxygen Species (1) Sodium Channel (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (3) Endocrinology (2) Infection (7) Inflammation/Immunology (1) Metabolic Disease (15) Neurological Disease (3)

By Targets:

5-HT Receptor (2)

ADC Cytotoxin (3)

Antibiotic (4)

Apoptosis (2)

Bacterial (6)

Biochemical Assay Reagents (3)

Bradykinin Receptor (1)

Calcium Channel (2)

Calmodulin (1)

Endogenous Metabolite (11)

Epigenetic Reader Domain (1)

GSK-3 (2)

IKK (1)

MEK (1)

Myosin (1)

Na+/H+ Exchanger (NHE) (2)

NF-κB (1)

P2Y Receptor (1)

Phosphatase (2)

Phosphodiesterase (PDE) (1)

Potassium Channel (1)

Prostaglandin Receptor (1)

Protease Activated Receptor (PAR) (1)

Ras (3)

Reactive Oxygen Species (1)

Sodium Channel (1)

By Research Areas:

Cancer (16)

Cardiovascular Disease (3)

Endocrinology (2)

Infection (7)

Inflammation/Immunology (1)

Metabolic Disease (15)

Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: PIKfyve

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134393B

6-Me-ATP trisodium N6-Methyl-ATP trisodium	GSK-3	Others
6-Me-ATP (N6-Methyl-ATP) trisodium is a N ⁶-modified ATP derivative. 6-Me-ATP trisodium shows excellent binding affinity to GSK3, serving as the phosphate group donor for GSK3β-catalyzed phosphorylation of its substrate peptide .

HY-P2992

Inorganic pyrophosphatase, Saccharomyces cerevisiae PPase	Endogenous Metabolite	Others
Inorganic pyrophosphatase, Saccharomyces cerevisiae (PPase) converts pyrophosphate (PPi) to phosphate. Inorganic pyrophosphatase is an essential component of in vitro transcription reactions for RNA preparation, is often used in biochemical studies. Inorganic pyrophosphatase is critical for driving cellular processes such as nucleic acid and protein synthesis .

HY-B0504S

Creatinine-d3 NSC13123-d₃	Endogenous Metabolite	Metabolic Disease Cancer
Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle[1].

HY-W110917

Dimethylsulfonazo III	Biochemical Assay Reagents	Others
Dimethylsulfonazo III is a potent sulfate indicator. Dimethylsulfonazo III can be used as indicator to test those samples contaminated with potassium or phosphate ions .

HY-134393

6-Me-ATP N6-Methyl-ATP	GSK-3	Others
6-Me-ATP (N6-Methyl-ATP) is a N ⁶-modified ATP derivative. 6-Me-ATP shows excellent binding affinity to GSK3, serving as the phosphate group donor for GSK3β-catalyzed phosphorylation of its substrate peptide .

HY-135655A

Fobrepodacin SPR720; pVXc-486	Bacterial	Infection
Fobrepodacin (SPR720) is an orally active and potent phosphate proagent of SPR719 (VXc-486; HY-12930). Fobrepodacin has potent bactericidal activities in vivo .

HY-P2952

Adenylate AMPK; Myokinase; Adk	Endogenous Metabolite	Others
Adenylate (Adk), i.e., myokinase, is a phosphotransferase enzyme, is often used in biochemical studies. Adenylate catalyzes the interconversion of adenosine phosphates. Adenylate monitors phosphate nucleotide levels inside the cell, it plays an important role in cellular energy homeostasis .

HY-P10209

Cilagicin	Antibiotic Bacterial	Infection
Cilagicin, a dodeca-lipodepsipeptide, is a Gram-positive active antibiotic. Cilagicin has a dual polyprenyl phosphate binding mechanism that impedes resistance development .

HY-P10211

Virgilagicin	Antibiotic Bacterial	Infection
Virgilagicin is a Gram-positive active antibiotic that has a dual polyprenyl phosphate binding mechanism that impedes resistance development .

HY-P3061

[Hyp3]-Bradykinin	Bradykinin Receptor	Cardiovascular Disease Endocrinology
[Hyp3]-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist. [Hyp3]-Bradykinin interacts with B2-bradykinin receptors and stimulates inositol phosphate production in cultured human fibroblasts .

HY-125150

AL-3138 11-Deoxy-16-fluoro PGF2α	Prostaglandin Receptor Endogenous Metabolite	Endocrinology
AL-3138 (11-Deoxy-16-fluoro PGF2α) is a prostaglandin F2 alpha (PGF2alpha) analogue that antagonises FP prostaglandin receptor-mediated inositol phosphate production .

HY-P0320A

EGF Receptor Substrate 2 (Phospho-Tyr5) (TFA)	Phosphatase Biochemical Assay Reagents	Others
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .

HY-P0320B

EGF Receptor Substrate 2 (Phospho-Tyr5) (acetate)	Phosphatase Biochemical Assay Reagents	Others
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .

HY-107469

Pyridoxal Pyridoxaldehyde	Endogenous Metabolite	Metabolic Disease
Pyridoxal is one of the major forms of vitamin B6. Pyridoxal is phosphorylated by pyridoxal kinase to Pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-Pyridoxic acid (HY-113493) which is excreted in the urine .

HY-15991

Tenapanor 4 Publications Verification AZD1722; RDX5791	Na+/H+ Exchanger (NHE)	Metabolic Disease
Tenapanor (AZD1722) is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor has the potential for the research of hyperphosphatemia .

HY-135655

Fobrepodacin disodium SPR720 disodium; pVXc-486 disodium	Bacterial	Infection
Fobrepodacin (SPR720) disodium is an orally active and potent phosphate proagent of SPR719 (VXc-486; HY-12930). Fobrepodacin disodium has potent bactericidal activities in vivo .

HY-W027446

Pyridoxal hydrochloride	Endogenous Metabolite	Metabolic Disease
Pyridoxal hydrochloride is the hydrochloride form of Pyridoxal (HY-107469). Pyridoxal is one of the major forms of vitamin B6. Pyridoxal is phosphorylated by pyridoxal kinase to Pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-Pyridoxic acid (HY-113493) which is excreted in the urine .

HY-136128

H3B-120	Potassium Channel	Cancer
H3B-120 is a highly selective, competitive and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor with an IC₅₀ of 1.5 μM and a K_i of 1.4 μM. H3B-120 has anti-cancer activity .

HY-15991A

Tenapanor hydrochloride 4 Publications Verification AZD1722 hydrochloride; RDX5791 hydrochloride	Na+/H+ Exchanger (NHE)	Metabolic Disease
Tenapanor (AZD1722) hydrochloride is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor hydrochloride reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor hydrochloride has the potential for the research of hyperphosphatemia .

HY-P2931

Triosephosphate isomerase TPI	Endogenous Metabolite	Others
Triosephosphate isomerase (TPI) is a glycolytic enzyme. Triosephosphate isomerase fast interconverts dihydroxyacetone phosphate and D: -glyceraldehyde-3-phosphate, its catalytic site is at the dimer interface .

HY-P4987

TRAP-7	Protease Activated Receptor (PAR)	Cardiovascular Disease
TRAP-7 is a thrombin receptor (PAR) activating peptide. TRAP-7 stimulates total inositol phosphate (IP) accumulation and phosphorylation of a specific endogenous substrate for activated PKC. TRAP-7 can be used in cardiovascular disease research .

HY-P10210

Paenilagicin	Antibiotic Bacterial	Infection
Paenilagicin is a Gram-positive active antibiotic with a unique diphosphorylated prenyl binding mechanism that does not induce drug resistance. Paenilagicin exhibits a MIC value of 2 μg/mL against multidrug-resistant Gram-positive bacteria .

HY-D0162

Malachite green hemioxalate 1 Publications Verification	IKK NF-κB Apoptosis	Cancer
Malachite green hemioxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green hemioxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green hemioxalate exhibits antitumor activity in vitro and in vivo .

HY-P2818

Alkaline phosphatase, Bovine intestine 1 Publications Verification Apase	Endogenous Metabolite	Metabolic Disease Cancer
Alkaline phosphatase, Bovine intestine (Apase) is a membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase can be used in molecular biology and enzyme-free analysis. Inhibition of tissue nonspecific alkaline phosphatase can block intracellular lipid accumulation .

HY-147063

N-Acetyl-α-D-glucosamine 1-phosphate disodium	Endogenous Metabolite	Others
N-acetyl-α-d-glucosamine 1-phosphate disodium (GlcNAc-1-P), an anomeric sugar phosphate, is a key intermediate in the biosynthesis of N-linked glycoproteins. N-acetyl-α-d-glucosamine 1-phosphate disodium is a metabolic precursor of the bacterial cell-wall components teichoic acid and mureine .

HY-125863

Glucose-6-phosphate dehydrogenase, Microorganism	Endogenous Metabolite	Metabolic Disease Cancer
Glucose-6-phosphate dehydrogenase, Microorganism is the rate-limiting enzyme of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase is a major source of NADPH that is required by many essential cellular systems including the antioxidant pathways, nitric oxide synthase, NADPH oxidase, cytochrome p450 system, and others. Glucose-6-phosphate dehydrogenase can be used for the research of diabetes, aldosterone-induced endothelial dysfunction, and cancer .

HY-135864

KRAS inhibitor-6

Ras Cancer

KRAS inhibitor-6 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound A .
HY-135866

KRAS inhibitor-8

Ras Cancer

KRAS inhibitor-8 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound C .
HY-135865

KRAS inhibitor-7

Ras Cancer

KRAS inhibitor-7 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound B .

KRAS inhibitor-6	Ras	Cancer
KRAS inhibitor-6 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound A .

KRAS inhibitor-8	Ras	Cancer
KRAS inhibitor-8 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound C .

KRAS inhibitor-7	Ras	Cancer
KRAS inhibitor-7 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound B .

HY-N1673

2,5-Dihydroxybenzaldehyde Gentisaldehyde	Bacterial	Infection
2,5-Dihydroxybenzaldehyde (Gentisaldehyde) is a naturally occurring antimicrobial that inhibits the growth of *Mycobacterium avium subsp. paratuberculosis. 2,5-Dihydroxybenzaldehyde is active against S. aureus* strains with a MIC₅₀ of 500 mg/L .

HY-145781

β-L-Fucopyranosyl phosphate	Others	Metabolic Disease
β-L-Fucopyranosyl phosphate can be used for the research of carbohydrate metabolism. Glycosyl phosphates play crucial roles in carbohydrate metabolism as metabolic regulators or ubiquitous intermediates for glycoconjugate biosynthesis .

HY-112939

Colestilan MCI-196; Colestimide	Others	Metabolic Disease
Colestilan (MCI-196) is a non-absorbed, non-calcium-based phosphate binder and is also a non-metallic, anion exchange resin. Colestilan is orally active and can be used for hypercholesterolaemia research .

HY-103138A

(Rac)-WAY-161503	5-HT Receptor	Neurological Disease Metabolic Disease
(Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT_2C receptor agonist with a K_i of 4 nM and an EC₅₀ of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT_2C than 5-HT_2A and 5-HT_2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects .

HY-100912

W-7 hydrochloride 1 Publications Verification	Phosphodiesterase (PDE) Myosin Apoptosis Calmodulin	Cancer
W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca ²⁺-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC₅₀ values of 28 μM and 51 µM, respectively . W-7 hydrochloride induces apoptosis and has antitumor activity .

HY-N1428C

Ferric citrate 1 Publications Verification Iron(III) citrate; Zerenex	Reactive Oxygen Species Antibiotic	Metabolic Disease
Ferric citrate (Iron(III) citrate), an orally active iron supplement, is an efficacious phosphate binder. Ferric citratee can be used for iron deficiency anemia and chronic kidney disease (CKD) research .

HY-113325A

NADP sodium hydrate 4 Publications Verification	Endogenous Metabolite	Others
NADP sodium hydrate, a β-Nicotinamide adenine dinucleotide phosphate sodium salt, is a redox cofactor. NADP sodium hydrate is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP ⁺) and reduced (NADPH) .

HY-N3394

Lecanoric acid	Others	Infection
Lecanoric acid is a histidine-decarboxylase inhibitor isolated from fungus. The inhibition by lecanoric acid is competitive with histidineand noncompetitive with pyridoxal phosphate. Lecanoric acid did not inhibit aromatic amino acid decarboxylase .

HY-147062

N-Acetyl-D-galactosamine-6-phosphate	Others	Metabolic Disease
N-acetyl-D-galactosamine 6-phosphate is a galactosamine phosphate that involved in galactose metabolism and phosphotransferase system (PTS). N-Acetyl-D-galactosamine-6-phosphate can be hydrolyze by NagA .

HY-103138

(Rac)-WAY-161503 hydrochloride	5-HT Receptor	Neurological Disease Metabolic Disease
(Rac)-WAY-161503 hydrochloride is a potent, selective, high affinity 5-HT_2C receptor agonist with a K_i of 4 nM and an EC₅₀ of 12 nM. (Rac)-WAY-161503 hydrochloride displays higher affinity for 5-HT_2C than 5-HT_2A and 5-HT_2B receptors. (Rac)-WAY-161503 hydrochloride has anti-obesity and antidepressant effects .

HY-103305

cis-Ned19

Others Cancer

cis-Ned19 is a chemical probe. cis-Ned19 blocks NAADP signaling and fluorescently labeled NAADP receptors in cell .

cis-Ned19	Others	Cancer
cis-Ned19 is a chemical probe. cis-Ned19 blocks NAADP signaling and fluorescently labeled NAADP receptors in cell .

HY-131041

Ned-K	Calcium Channel	Cardiovascular Disease
Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca ²⁺ oscillations in cardiomyocytes .

HY-131892

2-Deoxy-D-galactose	Others	Metabolic Disease Cancer
2-Deoxy-D-galactose is a glucose analog. 2-Deoxy-D-galactose inhibits glycolysis to inhibits tumor growth. 2-Deoxy-D-galactose is a substance interfering with the fucosylation of glycomacromolecules and impairing memory consolidation in various learning tasks. 2-Deoxy-d-galactose hinders glycoprotein fucosylation in vivo .

HY-108662

PIT 2,2'-Pyridylisatogen tosylate	P2Y Receptor	Inflammation/Immunology
PIT (2,2'-Pyridylisatogen tosylate) is a selective and non-competitive antagonist of P2Y1 receptor with an IC₅₀ value of 0.14 μM for human P2Y1 receptor. PIT antagonizes P2Y1 receptor signaling without affecting nucleotide binding. PIT is an irreversible antagonist of responses to ATP at metabotropic purinoceptors (of the P2Y family) in some smooth muscles. PIT can be used for the research of chronic bronchitis and asthma .

HY-135124

DC44SMe	ADC Cytotoxin	Cancer
DC44SMe, a phosphate proagent of cytotoxic DNA alkylator DC44, can be used in the synthesis of antibody-drug conjugate (ADC). DC44SMe exhibits IC₅₀s of 2.0 nM, 2.8 nM, and 1.9 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC44SMe can be used for the targeted treatment of cancer .

HY-135123

DC4SMe	ADC Cytotoxin	Cancer
DC4SMe, a phosphate proagent of cytotoxic DNA alkylator DC4, can be used in the synthesis of antibody-drug conjugate (ADC). DC4SMe exhibits IC₅₀s of 1.9 nM, 2.9 nM, and 1.8 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC4SMe can be used for the targeted treatment of cancer .

HY-13995B

Sevelamer carbonate 1 Publications Verification	Others	Metabolic Disease
Sevelamer carbonate is an orally active and non-calcium-based phosphate binding agent and used for the hyperphosphatemia of chronic kidney disease (CKD)research. Sevelamer carbonate effectively lowers serum phosphorus levels hile having minimal effect on serum calcium or serum chloride levels in vivo. Sevelamer carbonate is considered as an improved, buffered form of sevelamer (HY-13995) .

HY-131615

TPC2-A1-P 1 Publications Verification	Sodium Channel	Others
TPC2-A1-P is a powerful and membrane permeable agonist of two pore channel 2 (TPC2) with an EC₅₀ of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actions of PI(3,5)P2. TPC2-A1-P also shows higher potency to induce Na ²⁺ mobilisation from TPC2 than TPC-A1-N (HY-131614). TPC2-A1-P can be used to probe different functions of TPC2 channels in intact cells .

HY-144318

CREB-IN-1 TFA

Epigenetic Reader Domain Cancer

CREB-IN-1 TFA is a potent, orally active CREB inhibitor (IC₅₀=0.18 µM). CREB-IN-1 TFA inhibits breast cancer cell growth .

HY-131614

TPC2-A1-N 2 Publications Verification	Calcium Channel	Others
TPC2-A1-N is a powerful and Ca ²⁺-permeable agonist of two pore channel 2 (TPC2), which plays its role by mimicking the physiological actions of NAADP. TPC2-A1-P reproducibly evokes significant Ca ²⁺ responses from TPC2 (EC₅₀=7.8 μM), and the effect can be blocked by several TPC blockers. TPC2-A1-N can be used to probe different functions of TPC2 channels in intact cells .

HY-135125

DC4

ADC Cytotoxin Cancer

DC4, an ADC cytotoxin, can be used in the synthesis of antibody-drug conjugate (ADC). DC4 can be used for the targeted treatment of cancer .

Cat. No.	Product Name	Type