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photosensitizer

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (14) Autophagy (3) Bacterial (4) Bcl-2 Family (1) BCRP (1) Biochemical Assay Reagents (6) Caspase (1) Cholinesterase (ChE) (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (3) Endogenous Metabolite (3) Estrogen Receptor/ERR (1) Fluorescent Dye (14) Fungal (3) GLUT (1) MMP (2) Monoamine Oxidase (1) Necroptosis (1) Parasite (2) PARP (1) PKC (2) Pyroptosis (1) Pyruvate Kinase (1) Reactive Oxygen Species (13) YAP (2)
By Research Areas:	Cancer (49) Cardiovascular Disease (1) Endocrinology (2) Infection (10) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (2)
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-157503

Photosensitizer-3	Others	Cancer
Photosensitizer-3 is a photosensitizer that exhibits powerful selective killing effects on transfected HEK cells and affibody-targeted A431 cancer cells when exposed to near-infrared light excitation .

HY-D1293

Photosensitizer-1

Reactive Oxygen Species Others

Photosensitizer-1 (Compound CLB-13) is a photosensitizer .
HY-D1293A

Photosensitizer-1 hydrochloride

Reactive Oxygen Species Others

Photosensitizer-1 (Compound CLB-13) hydrochloride is a photosensitizer .

Photosensitizer-1	Reactive Oxygen Species	Others
Photosensitizer-1 (Compound CLB-13) is a photosensitizer .

Photosensitizer-1 hydrochloride	Reactive Oxygen Species	Others
Photosensitizer-1 (Compound CLB-13) hydrochloride is a photosensitizer .

HY-147690

Photosensitizer-2	Others	Cancer
Photosensitizer-2 (compound 1) is a organic D-π-A sensitizer against phototoxicity. Photosensitizer-2 contains an acrylic acid moiety that exerts high levels of phototoxicity. Photosensitizer-2 shows antitumor activity against HeLa cells, with IC₅₀ values of 20.9 ± 4.5 μM (dark) and 0.046 ± 0.012 μM (irradiation), respectively .

HY-146416

*Antitumor photosensitizer-2*	Others	Cancer
Antitumor photosensitizer-2 (Compound 11) is a potent photosensitizer. Antitumor photosensitizer-2 has outstanding photodynamic anti-tumor effects without obvious skin photo-toxicity, and can act as new agent candidates for photodynamic research .

HY-146414

*Antitumor photosensitizer-1*	Others	Cancer
Antitumor photosensitizer-1 (Compound 8) is a potent photosensitizer. Antitumor photosensitizer-1 has outstanding photodynamic anti-tumor effects without obvious skin photo-toxicity, and can act as new agent candidates for photodynamic research .

HY-145265

*Antimicrobial photosensitizer-1*	Bacterial	Infection
Antimicrobial photosensitizer-1 is a promising candidate as the antimicrobial photosensitizer for combating pathogenic microorganism infections. Antimicrobial photosensitizer-1 exhibits an impressive antimicrobial efficacy in S. aureus-infected mice wounds .

HY-156092

*Antitumor photosensitizer-4*	BCRP Apoptosis	Cancer
Antitumor photosensitizer-4 (compound 10b) is a potent tyrosine kinase inhibitor (TKI) targeting ABCG2. Antitumor photosensitizer-4 is a photosensitizer (PS) consisting of a conjugate of dasatinib (HY-10181) and imatinib (HY-15463). Antitumor photosensitizer-4 induces apoptosis and ROS production and exhibits strong phototoxicity to HepG2 and B16-F10 cells .

HY-147521

*Antitumor photosensitizer-3*	Necroptosis	Cancer
Antitumor photosensitizer-3 (Compound I) is a chlorin derivative. Antitumor photosensitizer-3 induces tumor cells apoptosis and necrosis under 650 nm laser irradiation. Antitumor photosensitizer-3 exhibits lower skin photo-toxicity than positive reference m-THPC in vivo .

HY-163034

*Antitumor photosensitizer-5*	Apoptosis Reactive Oxygen Species	Cancer
Antitumor photosensitizer-5 (Ru2) is a photosensitizer which effectively target tumor mitochondria with an IC₅₀ of 0.3 μM for phototoxicity to A549 cells. Under 460 nm light irradiation, antitumor photosensitizer-5 induces the generation of reactive oxygen species and NADH depletion, causes mitochondrial damage and activation of caspase-3, inducing apoptosis and suppressing cell migration. Antitumor photosensitizer-5 has the potential to prevent the growth of malignant tumors, therefore, shows the potential to be applied to photodynamic therapy .

HY-D1648

8-(2,4,6-Trimethylphenyl)-BODIPY	Fluorescent Dye	Others
8-(2,4,6-Trimethylphenyl)-BODIPY is a highly fluorescent dye, can be used as photosensitizer or synthesize other BODIPY-based photosensitizer (λ_abs=502 nm, λ_em=516 nm) (*abs: main absorption maxima) .

HY-157943

Hexyl 5-aminolevulinate HAL	Fluorescent Dye	Cancer
Hexyl 5-aminolevulinate (HAL) is a photosensitizer, and can increase the efficiency of PDT due to the high lipophilicity. Hexyl 5-aminolevulinate can be used for research of photodynamic therapy (PDT) .

HY-D1472

Azure A eosinate	Fluorescent Dye	Others
Azure A eosinate is a dye for hematological and histological applications. Azure A eosinate can be used as new photosensitizer prototypes to determine growth inhibition of Candida albicans .

HY-155070

SRE-II	DNA/RNA Synthesis Apoptosis	Cancer
SRE-II, an amide derivative, is an activatable photosensitizer for photodynamic cancer research with decreased fluorescence and photosensitizing capabilities. SRE-II can be further converted into the active photosensitizer SDU Red via carboxylesterase-catalyzed amide bond cleavage. SRE-II induces DNA damage and cell apoptosis in the presence of light. SRE-II can act as a promising theranostic agent for triple-negative breast cancer .

HY-117665

Fimaporfin

TPCS2a
Others Cancer

Fimaporfin (TPCS2a) is an endosomal/lysosomal-localizing photosensitizer .

Fimaporfin TPCS2a	Others	Cancer
Fimaporfin (TPCS2a) is an endosomal/lysosomal-localizing photosensitizer .

HY-P2213

GPLGIAGQ	MMP Apoptosis	Cancer
GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT) .

HY-P2213A

GPLGIAGQ TFA	MMP Apoptosis	Cancer
GPLGIAGQ TFA, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ TFA can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT) .

HY-16477

Talaporfin sodium 2 Publications Verification ME2906; Mono-L-aspartyl chlorin e6; NPe6	Others	Cancer
Talaporfin (ME2906) sodium is a chlorin based *photosensitizer*. Talaporfin sodium can be used for the research of various cancers by using photodynamic therapy (PDT) .

HY-137475

Chlorin e6 trimethyl ester 1 Publications Verification	Reactive Oxygen Species	Cancer
Chlorin e6 trimethyl ester, a methyl pheophorbide-a derivative, is a photosensitizer that can be used in photodynamic therapy (PDT) .

HY-D1673

Tetrabromorhodamine 123 bromide	Fluorescent Dye	Cancer
Tetrabromorhodamine 123 (TBR) bromide is a *photosensitizer. Tetrabromorhodamine 123 bromide can be used for the research of photo* dynamic therapy (PDT) and cancer .

HY-149778

Antifungal agent 87

Fungal Infection

Antifungal agent 87(10) acts as a highly potent PDT antimycotic photosensitizer (PDT-IC₅₀ = 1 nM for T. rubrum) .

Antifungal agent 87	Fungal	Infection
Antifungal agent 87(10) acts as a highly potent PDT antimycotic photosensitizer (PDT-IC₅₀ = 1 nM for T. rubrum) .

HY-U00128

PPA-904	Parasite	Infection Inflammation/Immunology
PPA-904 is a specific phenothiazine *photosensitizer* in photodynamic research (PDT) research, especially topical application for cutaneous leishmaniasis in vivo .

HY-137474

Purpurin 18 methyl ester	Others	Cancer
Purpurin 18 methyl ester, a chlorophyll-a derivative, is a photosensitizer that can be used in photodynamic therapy (PDT). Purpurin 18 methyl ester has photodynamic activity to induce cancer cell death .

HY-D1452

BDP-4

Fluorescent Dye Cancer

BDP-4 is an amino acid-modified near-infrared Aza-BODIPY photosensitizer, acts as an immune initiator for potent photodynamic research in melanoma .

BDP-4	Fluorescent Dye	Cancer
BDP-4 is an amino acid-modified near-infrared Aza-BODIPY photosensitizer, acts as an immune initiator for potent photodynamic research in melanoma .

HY-D1453

Immune initiator-1	Biochemical Assay Reagents	Cancer
Immune initiator-1 (Compound 1a) is an amino acid-modified near-infrared Aza-BODIPY photosensitizer, acts as an immune initiator for potent photodynamic research in melanoma .

HY-B0754

Hematoporphyrin Hematoporphyrin IX	Apoptosis Endogenous Metabolite	Cancer
Hematoporphyrin (Hematoporphyrin IX), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .

HY-B0754A

Hematoporphyrin dihydrochloride 10+ Cited Publications Hematoporphyrin IX dihydrochloride	Apoptosis Endogenous Metabolite	Cancer
Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin dihydrochloride can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .

HY-144314

PSDalpha	Estrogen Receptor/ERR	Cancer
PSDalpha is an ERα degrader conjugating photosensitizer (PS), triphenylamine benzothiadiazole (TB) and 17β-estradiol via an acetylene bond. PSDalpha shows excellent anti-proliferation performance on MCF-7 cells. The maximum absorption wavelength of PSDalpha in the visible region is located at 465 nm .

HY-126861

2'-Deoxy-5-formylcytidine	Reactive Oxygen Species	Others
2'-Deoxy-5-formylcytidine is an effective internal triplet photosensitizer in DNA. 2'-Deoxy-5-formylcytidine could act as a new hot spot in DNA photodamage .

HY-N10611

Elsinochrome A	Reactive Oxygen Species Apoptosis Autophagy Fungal Fluorescent Dye	Infection Cancer
Elsinochrome A is a perylene quinone photosensitizer, and can generate reactive oxygen species (ROS) to induce apoptosis and autophagy under light excitation. Elsinochrome A also shows antifungal activity against C. albicans biofilm through photodynamic antimicrobial chemotherapy (PACT). Elsinochrome A can be used for research of photodynamic therapy (PDT) (Ex: 460 nm) .

HY-157051

[Ru(DIP)2TAP]Cl2	Others	Cancer
[Ru(DIP)2TAP]Cl2, Ruthenium(II) polypyridyl compound, is a photosensitizer. [Ru(DIP)2TAP]Cl2 can be used for the research of photodynamic therapy (PDT) .

HY-137473

Methyl pyropheophorbide-a 1 Publications Verification Pyropheophorbide-a methyl ester	Apoptosis	Cancer
Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester), a chlorophyll-a derivative, is a potent photosensitizer that can be used in photodynamic therapy (PDT) of cancer. Methyl pyropheophorbide-a has photodynamic activity and can induce apoptosis and inhibit tumor growth .

HY-16488

Temoporfin 5+ Cited Publications m-THPC; KW2345	Reactive Oxygen Species	Cancer
Temoporfin (m-THPC), a reduced porphyrin, is a potent second-generation photosensitizer. Temoporfin can be used in the research of photodynamic therapy (PDT) for head and neck cancers .

HY-150015

4,5'-Dimethylangelicin-NHS	DNA/RNA Synthesis	Cancer
4,5'-Dimethylangelicin-NHS is a modified 4,5'-Dimethylangelicin containing an NHS. 4,5'-Dimethylangelicin is an angular furocoumarin with photochemical and photosensitizing properties. 4,5'-Dimethylangelicin can inhibit the DNA and RNA syntheses in Ehrlich ascites tumor cells alter irradiation at 365 nm. 4,5'-Dimethylangelicin has potential as a photochemotherapy agent .

HY-151940

Mal-Pc	Reactive Oxygen Species	Cancer
Mal-Pc is a versatile molecular photosensitizer designed based phthalocyanine and maleimides. Mal-Pc can react with GSH to deplete GSH and reduce aggregation, thereby improving ROS (Reactive Oxygen Species)-mediated effect of photodynamic therapy (PDT) in cancer cells .

HY-150970

ICy-OH	Pyroptosis	Cancer
ICy-OH, an iodinated photosensitizer, is an effective anticancer agent. ICy-OH can be used not only for deep tissue imaging (λ_ex=640 nm，λ_em=690-740 nm) but also to selectively induce cell death in pancreatic cancer cells via cell pyroptosis pathway .

HY-B1814

Vitamin K5 Synkamin; Synkamin base	Pyruvate Kinase Bacterial Fungal	Infection Cancer
Vitamin K5 (Synkamin) is a photosensitizer and a antimicrobial agent. Vitamin K5 is a specific PKM2 inhibitor with IC₅₀ values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 induces apoptosis of colon 26 cells. Vitamin K5 can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages .

HY-134990

Hematoporphyrin monomethyl ether 1 Publications Verification	Apoptosis	Cancer
Hematoporphyrin monomethyl ether, second generation of porphyrin-related photosensitizer, is characterized by its single form, high yield of singlet oxygen, high selectivity, and low toxicity, which has been widely used in the diagnosis and research of various tumors, including lung cancer, bladder cancer, and nevus flammeus and brain glioma .

HY-W130236

Methylene Violet 3RAX	Cholinesterase (ChE)	Cancer
Methylene Violet 3RAX is a phenazine dye to stain the mitochondria of cells. Methylene Violet 3RAX can change the molecular structure of DNA, undermine the module of DNA, and induce the generation of the reactive singlet oxygen. Methylene Violet 3RAX shows inhibition for human erythrocyte AChE and human plasma BChE with an K_is of 1.58, 0.51 μM, respectively. Methylene Violet 3RAX has the potential for the research of potential photosensitizers for mitochondrial targeting action in PDT (photodynamic therapy) .

HY-128972

Purpurin 18 1 Publications Verification	Reactive Oxygen Species	Others
Purpurin 18, a derivative of chlorophyll, is an interesting dihydroporphyrin for generating photosensitizers .

HY-128973

Pyropheophorbide-a

Reactive Oxygen Species Cancer

Pyropheophorbide-a (Ppa) is a promising photosensitizer for tumor photodynamic therapy (PDT) .
HY-111959

2-Selenouracil

1 Publications Verification

Reactive Oxygen Species Endocrinology

2-Selenouracil is a useful specialized photosensitizer for photodynamical therapy .

Pyropheophorbide-a	Reactive Oxygen Species	Cancer
Pyropheophorbide-a (Ppa) is a promising photosensitizer for tumor photodynamic therapy (PDT) .

2-Selenouracil 1 Publications Verification	Reactive Oxygen Species	Endocrinology
2-Selenouracil is a useful specialized photosensitizer for photodynamical therapy .

HY-13722

HPPH 3 Publications Verification Photochlor	Reactive Oxygen Species	Cancer
HPPH (Photochlor) is a second generation photosensitizer, which acts as a photodynamic therapy (PDT) agent.

HY-145241

TBTDC	Others	Neurological Disease
TBTDC is a highly efficient multifunctional organic photosensitizer with aggregation-induced emission for in vivo bioimaging and photodynamic research.

HY-131410

Sinoporphyrin sodium	Others	Cancer
Sinoporphyrin (sodium) (DVDMS-2) is a potential photosensitizer that inhibits tumor growth in vivo and in vitro and can be used in cancer research .

HY-D2189

IRDye 700DX IRDye 700DX NHS ester	Fluorescent Dye	Others
IRDye 700DX (IRDye 700DX NHS ester) is a near-infrared (NIR) phthalocyanine dye that acts as a highly flexible photosensitizer .

HY-W035051

TSPP tetrasodium	Fluorescent Dye	Infection Cancer
TSPP tetrasodium is a photosensitizer that has shown impressive effects in in vivo regression of cancer and microorganism infections (Ex: 413 nm, Em: 640 nm) .

HY-17644

Redaporfin LUZ11; F2BMet
Redaporfin (LUZ11) acts as a potent photosensitizer. Redaporfin causes direct antineoplastic effects as well as indirect immune-dependent destruction of malignant lesions .

HY-D0259

Erythrosine B Erythrosin extra bluish	Fluorescent Dye	Others
Erythrosine B is an artificial dye widely used in the food and textile industries. Erythrosine B is also a novel photosensitizer which has been used to develop animal models.

HY-157053

[Ru(dppn)2phen](PF6)2	Others	Cancer
[Ru(dppn)2phen](PF6)2 (compound 4) is a polypyridylruthenium compound used in photodynamic therapy (PDT). [Ru(dppn)2phen](PF6)2 is normally nontoxic under dark conditions and induces mitochondrial respiratory damage upon light exposure. [Ru(dppn)2phen](PF6)2 exhibits high levels of singlet oxygen quantum yield and phototoxicity against cancer cells .

Cat. No.	Product Name	Type

HY-D0259

Erythrosine B Erythrosin extra bluish	Fluorescent Dyes/Probes
Erythrosine B is an artificial dye widely used in the food and textile industries. Erythrosine B is also a novel photosensitizer which has been used to develop animal models.

HY-D1648

8-(2,4,6-Trimethylphenyl)-BODIPY	Fluorescent Dyes/Probes
8-(2,4,6-Trimethylphenyl)-BODIPY is a highly fluorescent dye, can be used as photosensitizer or synthesize other BODIPY-based photosensitizer (λ_abs=502 nm, λ_em=516 nm) (*abs: main absorption maxima) .

HY-D1472

Azure A eosinate	Dyes
Azure A eosinate is a dye for hematological and histological applications. Azure A eosinate can be used as new photosensitizer prototypes to determine growth inhibition of Candida albicans .

HY-D2189

IRDye 700DX

IRDye 700DX NHS ester
Dyes

IRDye 700DX (IRDye 700DX NHS ester) is a near-infrared (NIR) phthalocyanine dye that acts as a highly flexible photosensitizer .

HY-162129

Antitumor agent-131	Fluorescent Dyes/Probes
Antitumor agent-131 (Compound 2-p) is an ER fluorescent probe with an IC₅₀ value of 23 nM for HepG2 tumor cells. Antitumor agent-131 can be used as a photosensitizer for the study of cancer photodynamics .

HY-W127725

Thymolphthalexon tetrasodium

Dyes

Thymolphthalexon (tetrasodium) is an organic compound commonly used as a reagent in biochemical assays. It belongs to the family of thioxanthone derivatives and has strong antioxidant properties. Thymolphthalexon has several applications in the study of free radical response, oxidative stress, and aging. In addition, it can be used as a photosensitizer in photodynamic therapy for the improvement of cancer and other diseases.

HY-D1658

BDP 581/591 amine hydrochloride	Fluorescent Dyes/Probes
BDP 581/591 amine hydrochloride is a BODIPY dye linker. BDP 581/591 is a universal, photostable fluorophore. The addition of the amine group allows for the compound to react with carboxylic acids, activated NHS esters and other carbonyl groups .

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