pleiotropic

By Targets:	Apoptosis (1) COX (1) Endogenous Metabolite (2) IGF-1R (1) Insulin Receptor (1) LPL Receptor (1) Oxytocin Receptor (2) STAT (1)
By Research Areas:	Cancer (6) Endocrinology (5) Inflammation/Immunology (4) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10252

NVP-ADW742 2 Publications Verification ADW742; GSK 552602A; ADW	IGF-1R Insulin Receptor Apoptosis	Endocrinology Cancer
NVP-ADW742 (ADW742) is an orally active, selective IGF-1R tyrosine kinase inhibitor with an IC₅₀ of 0.17 μM. NVP-ADW742 inhibits insulin receptor (InsR) with an IC₅₀ of 2.8 μM. NVP-ADW742 induces pleiotropic antiproliferative/proapoptotic biologic sequelae in tumor cells .

HY-N1508

Ecliptasaponin A	Others	Inflammation/Immunology
Ecliptasaponin A , a pentacyclic triterpenoid saponin, is one of major compounds separated from Eclipta prostrate . Eclipta prostrate is considered as a nourishing herbal medicine with pleiotropic effects, including anti-inflammatory, hepatoprotective, antioxidant, and immunomodulatory .

HY-122506

Salviolone	STAT	Cancer
Salviolone is a natural diterpenoid derivative that can against melanoma cells. Salviolone exhibits a pleiotropic effect against melanoma by hampering cell cycle progression, STAT3 signaling, and malignant phenotype of A375 melanoma cells .

HY-17571A

Oxytocin acetate Maximum Cited Publications 11 Publications Verification α-Hypophamine acetate; Oxytocic hormone acetate	Oxytocin Receptor Endogenous Metabolite	Endocrinology Cancer
Oxytocin (α-Hypophamine) acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .

HY-N2191

Ecliptasaponin D
Ecliptasaponin D is a triterpenoid glucoside isolated from Eclipta alba (L.) Hassk which is the aerial part of Eclipta prostrate. Eclipta prostrate is considered as a nourishing herbal medicine with pleiotropic effects, including anti-inflammatory, hepatoprotective, antioxidant and immunomodulatory ^[1,2].

HY-17571

Oxytocin Maximum Cited Publications 11 Publications Verification α-Hypophamine; Oxytocic hormone	Oxytocin Receptor Endogenous Metabolite	Endocrinology Cancer
Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .

HY-129284

APHS	COX	Cancer
APHS is a specific and covalent COX-2 inhibitor with neuroprotective effects. COX-2 is a prostaglandin (PG) synthetase overexpressed in colorectal cancer (CRC) and has pleiotropic cancer-promoting effects. APHS modifies COX-2 by acetylating the active site (serine 516), thereby inhibiting prostaglandin production. The neuroprotective activity of APHS is inhibited by prostaglandin E2. APHS also co-inhibits the WNT pathway, an anti-tumor mechanism in addition to COX-2 inhibition .

HY-149004A

SLF1081851 TFA	LPL Receptor	Inflammation/Immunology
SLF1081851 (TFA) is a Spns2 inhibitor, inhibits S1P release (IC₅₀=1.93 μM). SLF1081851 (TFA) plays a key role in development and immune system .

Cat. No.	Product Name

HY-L020

Wnt/Hedgehog/Notch Compound Library	349 compounds
The developmental proteins Hedgehog, Notch and Wnt are key regulators of cell fate, proliferation, migration and differentiation in several tissues. Their related signaling pathways are frequently activated in tumors, and particularly in the rare subpopulation of cancer stem cells. The Wnt signaling pathway is a conserved pathway in animals. Deregulated Wnt signaling has catastrophic consequences for the developing embryo and it is now well appreciated that defective Wnt signaling is a causative factor for a number of pleiotropic human pathologies, including cancer. Hedgehog signaling pathway is linked to tumorigenesis and is aberrantly activated in a variety of cancers. The Notch signaling pathway is a highly conserved cell signaling system present in most animals. It plays an important role in cell-cell communication, and further regulates embryonic development. MCE designs a unique collection of 349 Wnt/Hedgehog/Notch signaling pathway-related small molecules. Wnt/Hedgehog/Notch Compound Library serves as a useful tool for stem cell research and anti-cancer drug screening.

Wnt/Hedgehog/Notch Compound Library

349 compounds

The developmental proteins Hedgehog, Notch and Wnt are key regulators of cell fate, proliferation, migration and differentiation in several tissues. Their related signaling pathways are frequently activated in tumors, and particularly in the rare subpopulation of cancer stem cells. The Wnt signaling pathway is a conserved pathway in animals. Deregulated Wnt signaling has catastrophic consequences for the developing embryo and it is now well appreciated that defective Wnt signaling is a causative factor for a number of pleiotropic human pathologies, including cancer. Hedgehog signaling pathway is linked to tumorigenesis and is aberrantly activated in a variety of cancers. The Notch signaling pathway is a highly conserved cell signaling system present in most animals. It plays an important role in cell-cell communication, and further regulates embryonic development.

MCE designs a unique collection of 349 Wnt/Hedgehog/Notch signaling pathway-related small molecules. Wnt/Hedgehog/Notch Compound Library serves as a useful tool for stem cell research and anti-cancer drug screening.

Cat. No.	Product Name	Target	Research Area

HY-17571A

Oxytocin acetate 10+ Cited Publications α-Hypophamine acetate; Oxytocic hormone acetate	Oxytocin Receptor Endogenous Metabolite	Endocrinology Cancer
Oxytocin (α-Hypophamine) acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .

HY-17571

Oxytocin 10+ Cited Publications α-Hypophamine; Oxytocic hormone	Oxytocin Receptor Endogenous Metabolite	Endocrinology Cancer
Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .

HY-P1760

Allatostatin IV

Peptides Neurological Disease

Allatostatin IV is an octapeptide. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects .
HY-P1786

Allatostatin II

Peptides Neurological Disease

Allatostatin II is a decapeptid. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects .

Allatostatin IV	Peptides	Neurological Disease
Allatostatin IV is an octapeptide. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects .

Allatostatin II	Peptides	Neurological Disease
Allatostatin II is a decapeptid. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects .

HY-P1882

Type A Allatostatin I	Peptides	Inflammation/Immunology
Type A Allatostatin I is a tridecapeptide. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects .

HY-P3216

Oxytocin free acid 9-Deamidooxytocin	Peptides	Endocrinology
Oxytocin free acid (9-Deamidooxytocin) is an analog of oxytocin in which the glycinamide residue at position 9 in oxytocin has been replaced by a glycine residue. Oxytocin is a pleiotropic, peptide hormone with broad implications for general health, adaptation, development, reproduction, and social behavior .

HY-P3216B

Oxytocin free acid TFA 9-Deamidooxytocin TFA	Peptides	Endocrinology
Oxytocin free acid (9-Deamidooxytocin) TFA is an analog of oxytocin in which the glycinamide residue at position 9 in oxytocin has been replaced by a glycine residue. Oxytocin is a pleiotropic, peptide hormone with broad implications for general health, adaptation, development, reproduction, and social behavior .

HY-P4720

Interleukin-6 fragment (human)	Peptides	Inflammation/Immunology Cancer
Interleukin-6 fragment (human) is a pleiotropic cytokine produced by lymphocytes and non-lymphocytes. The Interleukin-6 fragment (human) coding gene is located on human chromosome 7, with a length of approximately 5 kilobases. Interleukin-6 fragment (human) has potential applications in immune response, acute response, inflammation, tumors, and hematopoiesis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1508

Ecliptasaponin A	Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Inflammation/Immunology	Others
Ecliptasaponin A , a pentacyclic triterpenoid saponin, is one of major compounds separated from Eclipta prostrate . Eclipta prostrate is considered as a nourishing herbal medicine with pleiotropic effects, including anti-inflammatory, hepatoprotective, antioxidant, and immunomodulatory .

HY-122506

Salviolone	Structural Classification Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants	STAT
Salviolone is a natural diterpenoid derivative that can against melanoma cells. Salviolone exhibits a pleiotropic effect against melanoma by hampering cell cycle progression, STAT3 signaling, and malignant phenotype of A375 melanoma cells .

HY-17571A

Oxytocin acetate 10+ Cited Publications α-Hypophamine acetate; Oxytocic hormone acetate	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Cancer	Oxytocin Receptor Endogenous Metabolite
Oxytocin (α-Hypophamine) acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .

HY-17571

Oxytocin 10+ Cited Publications α-Hypophamine; Oxytocic hormone	Structural Classification Natural Products Monophenols Classification of Application Fields Animals Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology	Oxytocin Receptor Endogenous Metabolite
Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .

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