polycyclic

By Targets:	Antibiotic (1) Apoptosis (2) Aryl Hydrocarbon Receptor (2) Bacterial (1) Biochemical Assay Reagents (1) DNA/RNA Synthesis (2) Endogenous Metabolite (2) Fluorescent Dye (3) Influenza Virus (1) Isotope-Labeled Compounds (4) Liposome (1) MDM-2/p53 (1) NF-κB (1) Somatostatin Receptor (1) STAT (1)
By Research Areas:	Cancer (9) Infection (2) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W013570

Acenaphthylene 1 Publications Verification	Others	Others
Acenaphthylene is a polycyclic aromatic hydrocarbon (PAH). PAHs are derived naturally from coal and tar deposits, and produced by incomplete combustion of organic matter .

HY-W026772

Fluorene 1 Publications Verification	Fluorescent Dye	Others
Fluorene, a polycyclic aromatic hydrocarbon (PAH), is a precursor to other fluorene compounds. Fluorene and its derivative can be used as a precursor to fluorene-based dyes .

HY-W014075

1-Hydroxypyrene	Endogenous Metabolite	Metabolic Disease
1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes .

HY-N11501

7-epi-Isogarcinol	STAT Apoptosis	Cancer
7-epi-Isogarcinol is a polycyclic polyprenylated acylphloroglucinol (PPAP), with moderate antiproliferative activity. 7-epi-Isogarcinol blocks STAT3 signaling pathway, to induce apoptosis and inhibit cell migration .

HY-143770

Cap-dependent endonuclease-IN-16	Influenza Virus	Infection
Cap-dependent endonuclease-IN-16 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-16 is a pyridone polycyclic derivative. Cap-dependent endonuclease-IN-16 has the potential for the research of influenza (extracted from patent CN112778330A, compound 15A) .

HY-N2427

Adamantane	Others	Others
Adamantane, a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be used in research of surface recognition and drug delivery .

HY-W013053

Dibenz[a,h]anthracene DBA; 1,2,5,6-Dibenzanthracene; Benzo[k]tetraphene	DNA/RNA Synthesis Apoptosis MDM-2/p53	Cancer
Dibenz[a,h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms .

HY-111441

1,4-Chrysenequinone

Chrysene-1,4-dione
Aryl Hydrocarbon Receptor Cancer

1,4-Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR).

1,4-Chrysenequinone Chrysene-1,4-dione	Aryl Hydrocarbon Receptor	Cancer
1,4-Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR).

HY-121107

Chrysene 1 Publications Verification	Others	Cancer
Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties .

HY-W011845

DMBA 7,12-DMBA; 7,12-Dimethylbenzanthracene	Others	Cancer
DMBA has carcinogenic activity as a polycyclic aromatic hydrocarbon (PAH). DMBA is used to induce tumor formation in various rodent models .

HY-W007692

Acetylpyrazine 2-Acetylpyrazine	Others	Others
Acetylpyrazine (2-Acetylpyrazine) is used to form many polycyclic compounds, as useful structures in pharmaceuticals and perfumes. Acetylpyrazine is a component of the folates (vitamin B compounds) .

HY-B1727

Phenanthrene 1 Publications Verification
Phenanthrene is a polycyclic aromatic hydrocarbon (PAH) and has been frequently used as an indicator for monitoring PAH contaminated matrices . Phenanthrene induces oxidative stress and inflammation .

HY-121107S

Chrysene-d12	Isotope-Labeled Compounds	Cancer
Chrysene-d₁₂ is the deuterium labeled Chrysene. Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties[1].

HY-121360

Cylindrospermopsin	DNA/RNA Synthesis	Others
Cylindrospermopsin is a cyanotoxin produced by a variety of freshwater cyanobacteria. It is a polycyclic uracil derivative containing guanidine and sulfate groups, which can inhibit protein synthesis and covalently modify DNA or RNA .

HY-W441021

DSPE-Pyrene	Liposome	Others
DSPE-Pyrene is a phospholipid molecule with polycyclic aromatic hydrocarbon, and can be used for drug encapsulation, such as drug loaded liposomes or nanoparticles. Pyrene is a fluorescent probe whose spectrum is sensitive to the polarity of its environment.

HY-136301

Acid secretion-IN-1	Others	Inflammation/Immunology
Acid secretion-IN-1 is a polycyclic compound extracted from patent WO2018024188A1, Compound Example 17.4. Acid secretion-IN-1 is synthesized and used in the IDO inhibitor synthetic experiment .

HY-W026772S

Fluorene-d10	Fluorescent Dye Isotope-Labeled Compounds	Others
Fluorene-d₁₀ is the deuterium labeled Fluorene. Fluorene, a polycyclic aromatic hydrocarbon (PAH), is a precursor to other fluorene compounds. Fluorene and its derivative can be used as a precursor to fluorene-based dyes[1].

HY-W013570S

Acenaphthylene-d8 Acenaphthylene-d₈	Isotope-Labeled Compounds	Others
Acenaphthylene-d₈ is the deuterium labeled Acenaphthylene[1]. Acenaphthylene is a polycyclic aromatic hydrocarbon (PAH). PAHs are derived naturally from coal and tar deposits, and produced by incomplete combustion of organic matter[2].

HY-156228

RGB-1	Others	Cancer
RGB-1 is a polycyclic aromatic hydrocarbon molecule and a stabilizer of RNA G-quadruplexes. RGB-1 can promote the inhibition of RNA translation and reduce the expression of NRAS proto-oncogene in breast cancer cells .

HY-N12527

Hyperelamine A	NF-κB	Others
Hyperelamine A (compound 5) is a polycyclic polyprenylated acylphloroglucinols (PPAPs). Hyperelamine A exhibits inhibitory activity against LPS-activated NO production in BV-2 cells via TLR-4/NF κB signaling .

HY-N0823

Lithospermic acid (+)-Lithospermic acid	Others	Inflammation/Immunology
Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl₄)-induced acute liver damage in vitro and in vivo .

HY-B1727S

Phenanthrene-d10	Isotope-Labeled Compounds	Inflammation/Immunology
Phenanthrene-d₁₀ is the deuterium labeled Phenanthrene. Phenanthrene is a polycyclic aromatic hydrocarbon (PAH) and has been frequently used as an indicator for monitoring PAH contaminated matrices[1]. Phenanthrene induces oxidative stress and inflammation[2].

HY-W014075S

1-Hydroxypyrene-d9	Endogenous Metabolite	Metabolic Disease
1-Hydroxypyrene-d₉ is the deuterium labeled 1-Hydroxypyrene[1]. 1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes[2].

HY-111450

CB7993113	Aryl Hydrocarbon Receptor	Cancer
CB7993113 is a potent AHR antagonist, with an IC₅₀ of 0.33 μM. CB7993113 directly binds AHR protein and blocks AHR nuclear translocation. CB7993113 inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90% respectively .

HY-W127705

Quinacrine mustard dihydrochloride	Fluorescent Dye	Others
Quinacrine mustard dihydrochloride is a fluorochrome. Quinacrine mustard dihydrochloride as a polycyclic aromatic agent can be used as mutagenic agent induces the mutants of bacteria. Quinacrine mustard dihydrochloride induces cell cycle arrest at G2/M-phase. Quinacrine mustard dihydrochloride has the potential for the research of plant, animal, or human chromosomes .

HY-109542

Cyclopenthiazide	Others	Metabolic Disease
Cyclopenthiazide is a benzothiadiazine diuretic with antihypertensive properties. Cyclopenthiazide exerts a diuretic effect by inhibiting the reabsorption of sodium chloride and water at the distal renal tubules. Cyclopenthiazide increases the excretory capacity of the rat kidney .

HY-P10027

Clovibactin	Antibiotic Bacterial	Infection
Clovibactin is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .

HY-103609

Pyrene Benzo[def]phenanthrene	Biochemical Assay Reagents	Others
Pyrene is a polycyclic aromatic hydrocarbon (PAH) composed of four fused benzene rings. It has a distinct aromatic odor, produced by incomplete combustion of organic matter. Pyrene exhibits strong fluorescence, emitting in the blue region of the spectrum, making it useful as a probe for studying molecular interactions in solution and on surfaces. Pyrene is also used as a model compound for the study of PAHs in various environments and biological systems because of its ubiquity in these environments. However, long-term exposure to pyrene has been associated with potential health risks, including carcinogenicity and mutagenicity.

HY-P1206

CH 275	Somatostatin Receptor	Neurological Disease
CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst₁) with a K_i of 52 nM . CH 275 acts as a potent and selective sst₁ agonist (IC₅₀=30.9 nM) and also displays IC₅₀ values of 345 nM, >1 μM, >10 μM, >10 μM for human sst₃, sst₄, sst₂ and sst₅, respectively . CH 275 can be used for the research of alzheimer’s disease .

Cat. No.	Product Name	Type

HY-103609

Pyrene Benzo[def]phenanthrene	Dyes
Pyrene is a polycyclic aromatic hydrocarbon (PAH) composed of four fused benzene rings. It has a distinct aromatic odor, produced by incomplete combustion of organic matter. Pyrene exhibits strong fluorescence, emitting in the blue region of the spectrum, making it useful as a probe for studying molecular interactions in solution and on surfaces. Pyrene is also used as a model compound for the study of PAHs in various environments and biological systems because of its ubiquity in these environments. However, long-term exposure to pyrene has been associated with potential health risks, including carcinogenicity and mutagenicity.

Pyrene

Benzo[def]phenanthrene

Dyes

Pyrene is a polycyclic aromatic hydrocarbon (PAH) composed of four fused benzene rings. It has a distinct aromatic odor, produced by incomplete combustion of organic matter. Pyrene exhibits strong fluorescence, emitting in the blue region of the spectrum, making it useful as a probe for studying molecular interactions in solution and on surfaces. Pyrene is also used as a model compound for the study of PAHs in various environments and biological systems because of its ubiquity in these environments. However, long-term exposure to pyrene has been associated with potential health risks, including carcinogenicity and mutagenicity.

HY-W127705

Quinacrine mustard dihydrochloride	Fluorescent Dyes/Probes
Quinacrine mustard dihydrochloride is a fluorochrome. Quinacrine mustard dihydrochloride as a polycyclic aromatic agent can be used as mutagenic agent induces the mutants of bacteria. Quinacrine mustard dihydrochloride induces cell cycle arrest at G2/M-phase. Quinacrine mustard dihydrochloride has the potential for the research of plant, animal, or human chromosomes .

Cat. No.	Product Name	Type

HY-W441021

DSPE-Pyrene	Drug Delivery
DSPE-Pyrene is a phospholipid molecule with polycyclic aromatic hydrocarbon, and can be used for drug encapsulation, such as drug loaded liposomes or nanoparticles. Pyrene is a fluorescent probe whose spectrum is sensitive to the polarity of its environment.

Cat. No.	Product Name	Target	Research Area

HY-P1206

CH 275	Somatostatin Receptor	Neurological Disease
CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst₁) with a K_i of 52 nM . CH 275 acts as a potent and selective sst₁ agonist (IC₅₀=30.9 nM) and also displays IC₅₀ values of 345 nM, >1 μM, >10 μM, >10 μM for human sst₃, sst₄, sst₂ and sst₅, respectively . CH 275 can be used for the research of alzheimer’s disease .

HY-P3193A

Cyclic nona-L-arginine hydrochloride	Peptides	Others
Cyclic nona-L-arginine hydrochloride, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .

HY-P3193

Cyclic nona-L-arginine TFA

Peptides Others

Cyclic nona-L-arginine TFA, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .

Cyclic nona-L-arginine TFA	Peptides	Others
Cyclic nona-L-arginine TFA, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .

HY-P4102

Cyclic PSAP peptide	Peptides	Cancer
Cyclic PSAP peptide is a cyclic pentapeptide (DWLPK). Cyclic PSAP peptide exhibits agent-like properties and could inhibit metastatic spread and restrain tumor development in general in vivo .

HY-P10027

Clovibactin	Antibiotic Bacterial	Infection
Clovibactin is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W013570

Acenaphthylene 1 Publications Verification	Natural Products other families Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields	Others
Acenaphthylene is a polycyclic aromatic hydrocarbon (PAH). PAHs are derived naturally from coal and tar deposits, and produced by incomplete combustion of organic matter .

HY-W014075

1-Hydroxypyrene	Natural Products Monophenols Classification of Application Fields Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes .

HY-N2427

Adamantane	Structural Classification Natural Products Classification of Application Fields Other Diseases Plants Minerals Disease Research Fields	Others
Adamantane, a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be used in research of surface recognition and drug delivery .

HY-121107

Chrysene 1 Publications Verification	Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Others
Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties .

HY-N11501

7-epi-Isogarcinol	Structural Classification Natural Products Garcinia xanthochymus Hook. f. ex T. Anders. Source classification Guttiferae Plants	STAT Apoptosis
7-epi-Isogarcinol is a polycyclic polyprenylated acylphloroglucinol (PPAP), with moderate antiproliferative activity. 7-epi-Isogarcinol blocks STAT3 signaling pathway, to induce apoptosis and inhibit cell migration .

HY-121360

Cylindrospermopsin	Microorganisms Source classification	DNA/RNA Synthesis
Cylindrospermopsin is a cyanotoxin produced by a variety of freshwater cyanobacteria. It is a polycyclic uracil derivative containing guanidine and sulfate groups, which can inhibit protein synthesis and covalently modify DNA or RNA .

HY-N12527

Hyperelamine A	Structural Classification Hypericum elatoides R. Keller Source classification Phenols Polyphenols Hypericaceae Plants	NF-κB
Hyperelamine A (compound 5) is a polycyclic polyprenylated acylphloroglucinols (PPAPs). Hyperelamine A exhibits inhibitory activity against LPS-activated NO production in BV-2 cells via TLR-4/NF κB signaling .

HY-N0823

Lithospermic acid (+)-Lithospermic acid	Classification of Application Fields Labiatae Source classification Samanea saman (Jacq.) Merr. Other Phenylpropanoids Phenols Polyphenols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	Others
Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl₄)-induced acute liver damage in vitro and in vivo .

Cat. No.	Product Name	Chemical Structure

HY-121107S

Chrysene-d12
Chrysene-d₁₂ is the deuterium labeled Chrysene. Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties[1].

HY-W026772S

Fluorene-d10
Fluorene-d₁₀ is the deuterium labeled Fluorene. Fluorene, a polycyclic aromatic hydrocarbon (PAH), is a precursor to other fluorene compounds. Fluorene and its derivative can be used as a precursor to fluorene-based dyes[1].

HY-B1727S

Phenanthrene-d10
Phenanthrene-d₁₀ is the deuterium labeled Phenanthrene. Phenanthrene is a polycyclic aromatic hydrocarbon (PAH) and has been frequently used as an indicator for monitoring PAH contaminated matrices[1]. Phenanthrene induces oxidative stress and inflammation[2].

HY-W014075S

1-Hydroxypyrene-d9
1-Hydroxypyrene-d₉ is the deuterium labeled 1-Hydroxypyrene[1]. 1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes[2].

HY-W013570S

Acenaphthylene-d8
Acenaphthylene-d₈ is the deuterium labeled Acenaphthylene[1]. Acenaphthylene is a polycyclic aromatic hydrocarbon (PAH). PAHs are derived naturally from coal and tar deposits, and produced by incomplete combustion of organic matter[2].

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