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Results for "

polyketide

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Antibiotic (4) Apoptosis (4) ATP Synthase (1) Bacterial (12) Caspase (1) CGRP Receptor (1) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (1) Endogenous Metabolite (4) Endothelin Receptor (1) ERK (1) FKBP (1) FLT3 (1) Fungal (4) HIV (1) Influenza Virus (1) Isocitrate Dehydrogenase (IDH) (1) MEK (1) Mitochondrial Metabolism (1) Parasite (2) PDGFR (1) Sodium Channel (1) VEGFR (1)
By Research Areas:	Cancer (11) Infection (20) Inflammation/Immunology (6) Metabolic Disease (1) Neurological Disease (4)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139594

Polyketide synthase 13-IN-1

Others Infection Inflammation/Immunology

Polyketide synthase 13-IN-1 (compound 32) is a polyketide synthase 13 inhibitor .

Polyketide synthase 13-IN-1	Others	Infection Inflammation/Immunology
Polyketide synthase 13-IN-1 (compound 32) is a polyketide synthase 13 inhibitor .

HY-139595

Polyketide synthase 13-IN-2	Bacterial	Infection Inflammation/Immunology
Polyketide synthase 13-IN-2 (comp 42) is a polyketide synthase 13 inhibitor against Mycobacterium tuberculosis, with an MIC of 0.25 μg/mL .

HY-139596

Polyketide synthase 13-IN-3	Others	Infection Inflammation/Immunology
Polyketide synthase 13-IN-3 (compound 41) is a polyketide synthase 13 inhibitor，with a MIC of 0.0625-0.125 μg/mL against the M. tuberculosis strain H37Rv .

HY-N10302

Bipolamine G

Bacterial Endogenous Metabolite Infection

Bipolamine G is an antibacterial polyketide alkaloid .
HY-146162

Colletotrichalactones A

Others Cancer

Colletotrichalactones A is a polyketide that display moderate-to-potent cytotoxic activities against MCF7 cells with an IC₅₀ of 35.06 µM .
HY-116479

Citromycetin

Others Others

Citromycetin is an aromatic polyketide compound from Australian marine-derived and terrestrial Penicillium spp .
HY-121291

Aureothin

HIV Infection

Aureothin, is a natural polyketide, is a HIV inhibitor with an IC₅₀ of 5.3 nM. Aureothin is a microbial biolarvicide .

Bipolamine G	Bacterial Endogenous Metabolite	Infection
Bipolamine G is an antibacterial polyketide alkaloid .

Colletotrichalactones A	Others	Cancer
Colletotrichalactones A is a polyketide that display moderate-to-potent cytotoxic activities against MCF7 cells with an IC₅₀ of 35.06 µM .

Citromycetin	Others	Others
Citromycetin is an aromatic polyketide compound from Australian marine-derived and terrestrial Penicillium spp .

Aureothin	HIV	Infection
Aureothin, is a natural polyketide, is a HIV inhibitor with an IC₅₀ of 5.3 nM. Aureothin is a microbial biolarvicide .

HY-N10293

Monaschromone	Fungal Endogenous Metabolite	Infection
Monaschromone, a polyketide metabolite, significantly inhibits the growth of B. cinerea, A. solani, M. oryzae, and G. saubinettii, with the MIC values ranging from 6.25 to 12.5 μM .

HY-161099

Epifadin	Bacterial	Infection
Epifadin is an antimicrobial agent consisting of a non-ribosomally synthesized peptide, a polyketide component and a terminal modified amino acid moiety. Epifadin eliminates nasal Staphylococcus aureus .

HY-N12657

Retinestatin	Others	Neurological Disease
Retinestatin, a new polyol polyketide, can protect SH-SY5Y dopaminergic cells from MPP ⁺ (HY-W008719)-induced cytotoxicity. Retinestatin shows neuroprotective effects in an in vitro model of Parkinson’s disease .

HY-130307

Rubrofusarin	Bacterial	Neurological Disease Inflammation/Immunology Cancer
Rubrofusarin is an orange polyketide pigment from Fusarium graminearum . Rubrofusarin is also an active ingredient of the Cassia species and ameliorates chronic restraint stress (CRS) -induced depressive symptoms through PI3K/Akt signaling. Rubrofusarin has anticancer, antibacterial, and antioxidant effects .

HY-126679

Apoptolidin	ATP Synthase Apoptosis	Cancer
Apoptolidin is a polyketide isolated from Nocardiopsis bacteria . Apoptolidin is a selective mitochondrial F₁F_O ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC₅₀=10-17 ng/ml) but not in normal cells .

HY-111009

Swinholide A	Fungal	Infection
Swinholide A is the actin-binding marine polyketide and dimerizes actin with the K_d of ~ 50 nM . Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity .

HY-121300

Kendomycin (-)-TAN2162	Antibiotic Bacterial Endothelin Receptor CGRP Receptor	Infection Cancer
Kendomycin ((−)-TAN 2162) is a polyketide antibiotic with remarkable antibacterial and cancer cells cytotoxic activities. Kendomycin tends to be bacteriostatic rather than bactericidal and inhibits the growth of the methicillin-resistant Staphylococcus aureus (MRSA) strain COL at a low concentration (MIC of 5 μg/mL). Kendomycin is a potent antagonist of the endothelin receptor and a calcitonin receptor agonist which plays its role as an anti-osteoporotic agent .

HY-N10561

Wychimicin A	Bacterial	Infection
Wychimicin A is a spirotetronate polyketide, can be isolated from the rare actinomycete Actinocrispum wychmicini strain MI503-AF4. Wychimicin A shows strong antibacterial activity against methicillin-resistant Staphylococcus. aureus (IC₅₀=0.125-0.5 μg/mL) and Enterococcus. faecalis/faecium (IC₅₀=0.125-0.25 μg/mL) .

HY-N10560

Wychimicin C	Bacterial	Infection
Wychimicin C is a spirotetronate polyketide, can be isolated from the rare actinomycete Actinocrispum wychmicini strain MI503-AF4. Wychimicin C shows strong antibacterial activity against methicillin-resistant Staphylococcus. aureus (IC₅₀=0.125-0.5 μg/mL) and Enterococcus. faecalis/faecium (IC₅₀=0.125-0.25 μg/mL) .

HY-19828

Herboxidiene GEX1A	DNA/RNA Synthesis	Cancer
Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome .

HY-138140

Desertomycin A

Others Others

Desertomycin A is an aminopolyol polyketide containing a macrolactone ring .
HY-B0767

Spinosyn A

Others Others

Spinosyn A, a polyketide-derived macrolide produced by Saccharopolyspora spinosa, is a potent insecticide .
HY-N10298

Massarilactone H

Influenza Virus Infection

Massarilactone H, a polyketide, is a neuraminidase inhibitor, with an IC₅₀ of 8.18 µM .

Desertomycin A	Others	Others
Desertomycin A is an aminopolyol polyketide containing a macrolactone ring .

Spinosyn A	Others	Others
Spinosyn A, a polyketide-derived macrolide produced by Saccharopolyspora spinosa, is a potent insecticide .

Massarilactone H	Influenza Virus	Infection
Massarilactone H, a polyketide, is a neuraminidase inhibitor, with an IC₅₀ of 8.18 µM .

HY-107417

Hypothemycin	VEGFR MEK FLT3 PDGFR ERK	Cancer
Hypothemycin, a fungal polyketide, is a multikinase inhibitor with K_is of 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2, respectively .

HY-N10449

Resistomycin

Antibiotic Apoptosis Bacterial Cancer

Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis .

Resistomycin	Antibiotic Apoptosis Bacterial	Cancer
Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis .

HY-112514

1,3,6,8-Tetrahydroxynaphthalene 1 Publications Verification 1,3,6,8-THN; T4HN	Others	Others
1,3,6,8-Tetrahydroxynaphthalene (T4HN) is an indispensable precursor to DHN (1,8-Dihydroxynaphthalene) melanin and is an unique symmetrical compound of polyketide origin .

HY-N10362

Ellipyrone B	Dipeptidyl Peptidase	Metabolic Disease
Ellipyrone B, an antihyperglycemic γ-pyrone enclosed macrocyclic polyketide, shows inhibition potential against dipeptidyl peptidase-4 (IC₅₀=0.48 mM) .

HY-16944

Soraphen A (-)-Soraphen A; Soraphen A1α
Soraphen A ((-)-Soraphen A; Soraphen A1α) is a polyketide fungal inhibitor that targets acetyl-CoA carboxylase (ACC1) in vivo. Soraphen A can be isolated from Myxobacter cellulosum .

HY-N4301

Monensin B	Others	Others
Monensin B is a polyketide produced by Streptomyces cinnamonensis. Fermentations of Streptomyces cinnamonensis produce a mixture of Monensin A and Monensin B in a ratio dependent upon the relative concentrations of ethylmalonyl-CoA and methylmalonyl-CoA .

HY-130043

11-O-Methylpseurotin A	Others	Inflammation/Immunology
11-O-Methylpseurotin A is a compound of mixed polyketide synthase–nonribosomal peptide synthetase (PKS/NRPS) origin. 11-O-Methylpseurotin A selectively inhibits a Hof1 deletion strain .

HY-N11667

18-O-Demethylpederin	Others	Infection Cancer
18-O-Demethylpederin is a pederin analogue. Pederin is a natural polyketide compound extracted from Paederus for the first time. It is a non-protein insect toxin with a broad spectrum of biological activities, including antibacterial, antiviral, and antitumor .

HY-N6777

Penicillic acid 1 Publications Verification	Caspase Bacterial Apoptosis Antibiotic	Infection Cancer
Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 .

HY-N10292

Chaetosemin J	Fungal Endogenous Metabolite	Infection
Chaetosemin J, an antifungal metabolite, exhibits inhibitory activity against plant pathogenic fungi Botrytis cinerea, Alternaria solani, Magnaporthe oryzae, and Gibberella saubinettii, with MIC values ranging from 12.5-25 μM .

HY-116838

TAM-16	Bacterial	Infection
TAM-16 is a potent and orally active polyketide synthase 13 (Pks13) inhibitor with an IC₅₀ value of 0.32 μM. TAM-16 has promising activity against Mycobacterium tuberculosis. TAM-16 inhibits hERG cardiac ion channel .

HY-W663230

Eugenitin	Parasite	Infection
Eugenitin is a polyketide isolated from the fungus Mycoleptodiscus indicus that is related to the South American medicinal plant. Eugenitin inhibits Leishmania major with LD₅₀=39.9 μM. Eugenitin has low cytotoxicity (IC₅₀ >131 μM) against several human cancer cell lines .

HY-13557

Ascomycin Maximum Cited Publications 6 Publications Verification Immunomycin; FR-900520; FK520	FKBP Parasite Fungal Antibiotic	Infection Neurological Disease Inflammation/Immunology
Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research .

HY-122534

Mensacarcin	Mitochondrial Metabolism ADC Cytotoxin Apoptosis	Cancer
Mensacarcin, a highly complex polyketide, strongly inhibits cell growth universally in cancer cell lines and potently induces apoptosis in melanoma cells. Mensacarcin targets to mitochondria, affects energy metabolism in mitochondria, and activates caspase-dependent apoptotic pathways. Mensacarcin, an antibiotic, can be used as a cytotoxic component of antibody-drug conjugates (ADCs) .

HY-117145

Thiophene-2	Bacterial	Infection
Thiophene-2 (TP2) is a specific polyketide synthase 13 (Pks13) inhibitor. Thiophene-2 inhibits mycolic acid biosynthesis and rapidly leads to mycobacterial cell death. Thiophene-2 is active against *Mycobacterium tuberculosis* with a MIC value of 1 μM, and has potent anti-tuberculosis activity .

HY-12546

Brevetoxin B Brevetoxin-2; PbTx-2	Sodium Channel	Neurological Disease
Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC₅₀=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively.

HY-117760

Spirolaxine	Bacterial Endogenous Metabolite	Infection
Spirolaxine is a plant growth inhibitor and possess significant anti-Helicobacter pylori activity. Spirolaxine exhibits cholesterol-lowering activity .

HY-N12390

Alternaphenol B2	Isocitrate Dehydrogenase (IDH)	Cancer
Alternaphenol B2 is a selective IDH1 inhibitor from the coral-derived fungus Parengyodontium album SCSIO SX7W11. Alternaphenol B2 shows inhibitory activity against isocitrate dehydrogenase mutant R132H (IDH1m), with IC₅₀ values of 41.9 μM .

Bipolamine G	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields	Bacterial Endogenous Metabolite
Bipolamine G is an antibacterial polyketide alkaloid .

Citromycetin	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Marine natural products Other Diseases Phenols Polyphenols Disease Research Fields Marine microorganism	Others
Citromycetin is an aromatic polyketide compound from Australian marine-derived and terrestrial Penicillium spp .

Monaschromone	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Disease Research Fields	Fungal Endogenous Metabolite
Monaschromone, a polyketide metabolite, significantly inhibits the growth of B. cinerea, A. solani, M. oryzae, and G. saubinettii, with the MIC values ranging from 6.25 to 12.5 μM .

Retinestatin	Structural Classification Natural Products Microorganisms Source classification	Others
Retinestatin, a new polyol polyketide, can protect SH-SY5Y dopaminergic cells from MPP ⁺ (HY-W008719)-induced cytotoxicity. Retinestatin shows neuroprotective effects in an in vitro model of Parkinson’s disease .

Rubrofusarin	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Neurological Disease Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Inflammation/Immunology	Bacterial
Rubrofusarin is an orange polyketide pigment from Fusarium graminearum . Rubrofusarin is also an active ingredient of the Cassia species and ameliorates chronic restraint stress (CRS) -induced depressive symptoms through PI3K/Akt signaling. Rubrofusarin has anticancer, antibacterial, and antioxidant effects .

Apoptolidin	Natural Products Microorganisms Source classification Disease Research Fields Cancer	ATP Synthase Apoptosis
Apoptolidin is a polyketide isolated from Nocardiopsis bacteria . Apoptolidin is a selective mitochondrial F₁F_O ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC₅₀=10-17 ng/ml) but not in normal cells .

Swinholide A	Infection Structural Classification Natural Products Classification of Application Fields Animals Source classification Marine natural products Sponge Disease Research Fields	Fungal
Swinholide A is the actin-binding marine polyketide and dimerizes actin with the K_d of ~ 50 nM . Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity .

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polyketide

Inhibitors & Agonists

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Natural
Products