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Results for "

polyphenol

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Antibiotic (1) Apoptosis (7) Autophagy (3) Bacterial (4) Biochemical Assay Reagents (1) c-Myc (1) Calcium Channel (1) Endogenous Metabolite (11) Fatty Acid Synthase (FASN) (1) Fungal (1) HBV (1) HIV (1) Isotope-Labeled Compounds (3) Keap1-Nrf2 (3) MMP (1) NF-κB (2) NOD-like Receptor (NLR) (1) Notch (1) p38 MAPK (1) PDGFR (1) PPAR (1) Reactive Oxygen Species (2) SARS-CoV (2) Sirtuin (1) Tyrosinase (3) Virus Protease (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (1) Infection (8) Inflammation/Immunology (17) Metabolic Disease (9) Neurological Disease (2)

By Targets:

Amyloid-β (1)

Antibiotic (1)

Apoptosis (7)

Autophagy (3)

Bacterial (4)

Biochemical Assay Reagents (1)

c-Myc (1)

Calcium Channel (1)

Endogenous Metabolite (11)

Fatty Acid Synthase (FASN) (1)

Fungal (1)

HBV (1)

HIV (1)

Isotope-Labeled Compounds (3)

Keap1-Nrf2 (3)

MMP (1)

NF-κB (2)

NOD-like Receptor (NLR) (1)

Notch (1)

p38 MAPK (1)

PDGFR (1)

PPAR (1)

Reactive Oxygen Species (2)

SARS-CoV (2)

Sirtuin (1)

Tyrosinase (3)

Virus Protease (1)

By Research Areas:

Cancer (16)

Cardiovascular Disease (1)

Infection (8)

Inflammation/Immunology (17)

Metabolic Disease (9)

Neurological Disease (2)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125860

Tyrosinase, Mushroom polyphenol oxidase	Tyrosinase	Metabolic Disease
Tyrosinase (EC 1.14.18.1) (Polyphenol oxidase) is a rate-limiting enzyme that controls the production of melanin and is encoded by TYR gene. Tyrosinase is mainly found in melanosomes synthesized by skin melanocytes .

HY-N1925

Tea polyphenol	Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Cancer
Tea polyphenol is the floorboard of phenolic compounds in tea. Tea polyphenol exhibits biological activity including antioxidant and anti-cancer activities, inhibition of cell proliferation, induction of apoptosis, cell cycle arrest and modulation of carcinogen metabolism .

HY-N0001A

(+)-Epicatechin

Dexepicatechin; (+)-Epicatechol
Others Others

(+)-Epicatechin (Dexepicatechin) is a catechin and a polyphenol, with antioxidant activities .

(+)-Epicatechin Dexepicatechin; (+)-Epicatechol	Others	Others
(+)-Epicatechin (Dexepicatechin) is a catechin and a polyphenol, with antioxidant activities .

HY-N11790

Resveratrol-4′-O-(6′′-O-galloyl)-glucopyranoside	Others	Others
Resveratrol-4′-O-(6′′-O-galloyl)-glucopyranoside is a polyphenol glycoside which can be isolated from Rheum tanguticum Maxim .

HY-N10668

2-(3-Hydroxy-2-oxoindolin-3-yl)-acetic acid

Others Others

2-(3-Hydroxy-2-oxoindolin-3-yl)-acetic acid (compound 29) is a natural polyphenol compound found in hop bract .
HY-29035

Dopamine acrylamide

Others Others

Dopamine acrylamide, a polyphenol derivative, can cross-link collagen mainly via noncovalent bonding under acidic-non-oxidized conditions .

2-(3-Hydroxy-2-oxoindolin-3-yl)-acetic acid	Others	Others
2-(3-Hydroxy-2-oxoindolin-3-yl)-acetic acid (compound 29) is a natural polyphenol compound found in hop bract .

Dopamine acrylamide	Others	Others
Dopamine acrylamide, a polyphenol derivative, can cross-link collagen mainly via noncovalent bonding under acidic-non-oxidized conditions .

HY-N9919

Glyasperin C	Others	Others
Glyasperin C is a potent and reversible noncompetitive inhibitor of neuraminidase with an IC₅₀ of 20% at 200 μM. Glyasperin C is a polyphenol isolated from the roots of Glycyrrhiza uralensis .

HY-N12523

Chebulanin	NF-κB p38 MAPK	Inflammation/Immunology
Chebulanin, a polyphenol acid, exerts its anti-inflammatory and anti-arthritic effects via inhibiting NF-κB and MAPK activation in collagen-induced arthritis mice. Chebulanin inhibits the nuclear translocation of p38 and p65 in LPS-stimulated macrophages .

HY-129137

Cyanidin 3-sophoroside chloride Cy 3-soph	Others	Others
Cyanidin 3-sophoroside chloride is a potent non-competitive reversible polyphenol oxidase (PPO) inhibitor. Also, Cyanidin 3-sophoroside chloride can be used as an anti-browning agent to inhibit the degree of PPO browning, enhance the antioxidant damage capacity of fruits and prolong the storage period .

HY-113732

Kazinol F	SARS-CoV	Infection Inflammation/Immunology
Kazinol F is a polyphenol from Broussonetia papyrifera. Kazinol F also is an effective Mpro inhibitor. Kazinol F has interaction with both the catalytic residues (His41 and Cys145) of Mpro and exhibits good binding affinity. Kazinol F can be used for the research of COVID-19 .

HY-N0063

Punicalagin 5 Publications Verification	SARS-CoV HBV	Infection Metabolic Disease Cancer
Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CL ^pro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19 .

HY-N7664

Isotheaflavin

Others Others

Isotheaflavin is one of antioxidant polyphenols in black tea .

Isotheaflavin	Others	Others
Isotheaflavin is one of antioxidant polyphenols in black tea .

HY-N9790

Procyanidin B2 3,3'-di-O-gallate	Notch	Others
Procyanidin B2, 3,3'-di-O-gallate is an active constituent. Procyanidin B2, 3,3'-di-O-gallate can be isolated from grape seed extract (GSE) procyanidin mix. Procyanidin B2, 3,3' -di-o-gallate target cancer stem cells (CSCs) in prostate cancer (PCa). Procyanidin B2, 3,3'-di-O-gallate targets both unsorted and sorted CSCs at lower doses. Procyanidin B2, 3,3'-di-O-gallate strongly suppresses the constitutive as well as Jagged1 (Notch1 ligand)-induced activated Notch1 pathway .

HY-N0522

(-)-Gallocatechin gallate 2 Publications Verification (-)-Gallocatechol gallate	Others	Cancer
(-)-Gallocatechin gallate is the polyphenol isolated from tea, with cancer-preventive activities.

HY-N0521A

(+)-Gallocatechin

1 Publications Verification

Others Cancer

(+)-Gallocatechin is a polyphenol compound from green tea, possesses anticancer activity .
HY-113158

4-Hydroxyhippuric acid

Others Others

4-Hydroxyhippuric acid is a by-product of metabolism of polyphenols and increases the microflora activity related to the refeeding .

(+)-Gallocatechin 1 Publications Verification	Others	Cancer
(+)-Gallocatechin is a polyphenol compound from green tea, possesses anticancer activity .

4-Hydroxyhippuric acid	Others	Others
4-Hydroxyhippuric acid is a by-product of metabolism of polyphenols and increases the microflora activity related to the refeeding .

HY-113357

m-Coumaric acid	Endogenous Metabolite	Inflammation/Immunology
m-Coumaric acid is a polyphenol metabolite from caffeic acid, formed by the gut microflora and the amount in human biofluids is diet-dependant.

HY-N4146

Proanthocyanidin A4

Others Inflammation/Immunology

Proanthocyanidin A4 is a polyphenol found in a variety of plants. Proanthocyanidin A4 possesses anti-inflammatory effects .

Proanthocyanidin A4	Others	Inflammation/Immunology
Proanthocyanidin A4 is a polyphenol found in a variety of plants. Proanthocyanidin A4 possesses anti-inflammatory effects .

HY-N0704

Agrimol B	Sirtuin PPAR Fatty Acid Synthase (FASN) c-Myc Bacterial	Infection Metabolic Disease Cancer
Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27 .

HY-N1579

Pyrogallol 2 Publications Verification
Pyrogallol is a polyphenol compound, which has anti-fungal and anti-psoriatic properties. Pyrogallol is a reductant that is able to generate free radicals, in particular superoxide anions.

HY-N1902

4-Hydroxyphenylacetic acid
4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2 .

HY-N0521AS

(+)-Gallocatechin-13C3	Isotope-Labeled Compounds	Cancer
(+)-Gallocatechin- ¹³C₃ is the ¹³C-labeled (+)-Gallocatechin. (+)-Gallocatechin is a polyphenol compound from green tea, possesses anticancer activity[1].

HY-150521

Hispolon	Antibiotic	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Hispolon, a polyphenol, can be isolated from Phellinus linteus. Hispolon possesses anticancer, antidiabetic, antioxidant, antiviral, hepatoprotective, anti-diabetic, and anti-inflammatory activities .

HY-Z0548

Methyl 3,4-dihydroxybenzoate Protocatechuic acid methyl ester; Methyl protocatechuate
Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect .

HY-N0017

Bergenin Cuscutin	Autophagy Apoptosis Bacterial Fungal Virus Protease	Infection Inflammation/Immunology Cancer
Bergenin is a cytoprotective and antioxidative polyphenol found in many medicinal plants. Bergenin has a wide spectrum activities such as hepatoprotective, antiinflammatory, immunomodulatory, antitumor, antiviral, and antifungal properties .

HY-N2593

Isorhapontigenin 1 Publications Verification	Autophagy	Inflammation/Immunology Cancer
Isorhapontigenin, an orally bioavailable dietary polyphenol isolated from the Chinese herb Gnetum cleistostachyum, displays anti-inflammatory effects. Isorhapontigenin induces autophagy and inhibits invasive bladder cancer formation .

HY-N4117

Hamamelitannin	Bacterial	Infection
Hamamelitannin, a polyphenol extracted from the bark of Hamamelis virginiana, is a quorum-sensing (QS) inhibitor. Hamamelitannin increases antibiotic susceptibility of staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release .

HY-113357S

m-Coumaric acid-13C3	Endogenous Metabolite	Inflammation/Immunology
m-Coumaric acid- ¹³C₃ is the ¹³C-labeled m-Coumaric acid. m-Coumaric acid is a polyphenol metabolite from caffeic acid, formed by the gut microflora and the amount in human biofluids is diet-dependant.

HY-N11823

Quercetin 3,7-diglucoside

Biochemical Assay Reagents Others

Quercetin 3,7-diglucoside is an antioxidant that can be obtained from the leaves of Ficus carica L .

Quercetin 3,7-diglucoside	Biochemical Assay Reagents	Others
Quercetin 3,7-diglucoside is an antioxidant that can be obtained from the leaves of Ficus carica L .

HY-N0295

Protocatechualdehyde Catechaldehyde; Protocatechuic aldehyde; Rancinamycin IV	Reactive Oxygen Species Bacterial Endogenous Metabolite	Infection Cancer
Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent .

HY-N1902S

4-Hydroxyphenylacetic acid-d6	Keap1-Nrf2 Endogenous Metabolite	Metabolic Disease
4-Hydroxyphenylacetic acid-d₆ is the deuterium labeled 4-Hydroxyphenylacetic acid. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1].

HY-N10647

Isoscutellarein 8-O-β-D-glucuronide	Others	Inflammation/Immunology
Isoscutellarein 8-O-β-D-glucuronide is a flavonoid antioxidant, can be isolated from Theobroma grandiflorum seeds .

HY-N1902S1

4-Hydroxyphenylacetic acid-d4	Keap1-Nrf2 Endogenous Metabolite	Metabolic Disease
4-Hydroxyphenylacetic acid-d₄ is the deuterium labeled 4-Hydroxyphenylacetic acid[1]. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[2].

HY-N2485

4'-Methoxyresveratrol 1 Publications Verification 4'-O-Methylresveratrol	NF-κB NOD-like Receptor (NLR)	Inflammation/Immunology
4'-Methoxyresveratrol (4'-O-Methylresveratrol) is a polyphenol derived from Dipterocarpaceae, with antiandrogenic, antifungal and anti-inflammatory activities. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation .

HY-Z0548S1

Methyl 3,4-dihydroxybenzoate-d3-1	Isotope-Labeled Compounds Keap1-Nrf2 Apoptosis	Inflammation/Immunology Cancer
Methyl 3,4-dihydroxybenzoate-d₃-1 is the deuterium labeled Methyl 3,4-dihydroxybenzoate. Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect[1].

HY-N0192

Arbutin 1 Publications Verification β-Arbutin	Tyrosinase Endogenous Metabolite	Cancer
Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with K_i ^app values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents . Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties .

HY-N4298

Epitheaflagallin 3-O-gallate	MMP	Metabolic Disease Inflammation/Immunology
Epitheaflagallin 3-O-gallate is a minor polyphenol in black tea. Epitheaflagallin 3-O-gallate exhibits versatile physiological functions in vivo and in vitro, including antioxidative activity, pancreatic lipase inhibition, Streptococcus sorbinusglycosyltransferase inhibition, and an inhibiting effect on the activity of matrix metalloprotease-1 and -3 and their synthesis by human gingival fibroblasts .

HY-N2342

Procyanidin C1 3 Publications Verification PCC1
Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice .

HY-129440

N-(p-Coumaroyl) Serotonin	PDGFR	Metabolic Disease Inflammation/Immunology
N-(p-Coumaroyl) Serotonin is a polyphenol isolated from the seeds of safflower and has antioxidative, anti-atherogenic and anti-inflammatory properties. N-(p-Coumaroyl) Serotonin inhibits PDGF-induced on phosphorylation of PDGF receptor and Ca ²⁺ release from sarcoplasmic reticulum . N-(p-Coumaroyl) Serotonin ameliorates atherosclerosis and distensibility of the aortic wall in vivo and is usually used for the atherosclerosis research .

HY-N0192S

Arbutin-d4 β-Arbutin-d₄	Isotope-Labeled Compounds Tyrosinase Endogenous Metabolite	Cancer
Arbutin-d₄ is deuterium labeled Arbutin. Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents[1]. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[2][3].

HY-13653

(-)-Epigallocatechin Gallate Maximum Cited Publications 29 Publications Verification EGCG; Epigallocatechol Gallate	Endogenous Metabolite Apoptosis	Inflammation/Immunology Cancer
(-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .

HY-N11288

Methyl salvionolate A	HIV	Infection
Methyl salvionolate A is a potent inhibitor of HIV-1. Methyl salvionolate A inhibits P24 antigen in HIV-1 infected MT-4 cell with an EC₅₀ of 1.62 μg/ml. Methyl salvionolate A also inhibits HIV-1 reverse transcriptase, protease and integrase with IC₅₀s of 50.58, 10.73 and 7.58 μg/ml, respectively .

HY-150526

EGCG-4″-sulfate	Endogenous Metabolite Apoptosis	Inflammation/Immunology Cancer
EGCG-4″-sulfate is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate sulfate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. EGCG-4″-sulfate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .

HY-N1445

Isoquercetin 1 Publications Verification Quercetin 3-glucoside
Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway . Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Isoquercetin has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies .

HY-13653R

(-)-Epigallocatechin Gallate (Standard) Maximum Cited Publications 29 Publications Verification EGCG(Standard); Epigallocatechol Gallate (Standard)	Endogenous Metabolite Apoptosis	Inflammation/Immunology Cancer
(-)-Epigallocatechin Gallate (Standard) is the analytical standard of (-)-Epigallocatechin Gallate. This product is intended for research and analytical applications. (-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .

HY-135897

Urolithin C 2 Publications Verification	Calcium Channel Reactive Oxygen Species Apoptosis Endogenous Metabolite	Metabolic Disease
Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca ²⁺ channel opener and enhances Ca ²⁺ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation .

HY-147547

SV5	Amyloid-β	Neurological Disease
SV5 is a potent anti-Alzheimer agent. SV5 can significantly protect SHSY-5Y cells against Aβ_1-42-induced death. SV5 shows moderate antioxidant and good neuroprotective activities. SV5 shows the high stability in human plasma and the best pharmacological profile .

Cat. No.	Product Name

HY-L057

Phenols Library

1183 compounds

Phenolic compounds are usually referred to as a diverse group of naturally occurring compounds with multiple medical properties, such as antioxidants, antimicrobial properties. Those compounds are commonly found in food and plants. They have high synthetic, medicinal and industrial values. Polyphenols are compounds with multiple phenolic functionalities. Naturally occurring polyphenols are known to have biological activities for use as drugs, for example, in diseases like AIDS, heart ailments, ulcer formation, bacterial infection, mutagenesis and neural disorders.

MCE offers a unique collection of 1183 natural phenol compounds which is a useful tool for drug discovery as an important source of lead compounds.

HY-L094

Food-Sourced Compound Library

1984 compounds

The health benefits deriving from the consumption of certain foods have been common knowledge. All foods are made up of chemical substances. Chemicals in foods are largely harmless and often desirable. At present, numerous researchers have been focused on the beneficial role played by certain food components in the close relationship between food intake and health status. For example, polyphenols, a common class of compounds among foods, are well-known antioxidants, which may play a role in the prevention of several diseases including type 2 diabetes, cardiovascular diseases, and some types of cancer.

MCE supplies a unique collection of 1984 compounds from variety of foods. All compounds are with specific food source(s). MCE Food-Sourced Compound Library is the useful tool to discover molecules with pharmaceutical activity from foods.

HY-L163

FDA-Approved Traditional Chinese Medicine Active Compound Library

324 compounds

Traditional Chinese medicine provides abundant natural resources for medicinal compounds, which are often considered effective and safe for drug discovery. Traditional Chinese medicine is based on the principle of "multiple components, multiple targets, and multiple pathways", and naturally has multiple pharmacological effects. As herbal medicine, the secondary plant metabolites in Chinese herbal medicine play an important role in alleviating many diseases in Traditional medicine and folk use. Therefore, the identification of traditional Chinese medicine derived compounds is also an important process in drug development and a necessary factor in dissecting the overall mechanism of action of traditional Chinese medicine. FDA listed compounds have completed extensive preclinical and clinical studies, exhibiting good biological activity, safety, and bioavailability.

MCE designs a unique collection of 324 FDA-approved traditional Chinese medicine active compounds, including flavonoids, polyphenols, alkaloids, terpenoids, and other structural types. It is a good tool for drug reuse and screening drugs from traditional Chinese medicine sources.

Cat. No.	Product Name	Category	Target	Chemical Structure