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Results for "

pregnane

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenylate Cyclase (1) Antibiotic (4) Apoptosis (5) Autophagy (6) Bacterial (4) Calcium Channel (1) CaSR (1) Constitutive Androstane Receptor (1) Cytochrome P450 (3) Drug Metabolite (1) Endogenous Metabolite (8) Fungal (4) FXR (1) HMG-CoA Reductase (HMGCR) (1) IKK (4) Isotope-Labeled Compounds (2) Keap1-Nrf2 (4) Ligands for E3 Ligase (1) Mitophagy (4) Organoid (1) PKC (1) Sirtuin (4)
By Research Areas:	Cancer (12) Endocrinology (6) Infection (5) Inflammation/Immunology (6) Metabolic Disease (8) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W006492S

*5a-Pregnane-3,20-dione-d6*	Endogenous Metabolite	Endocrinology Cancer
5a-Pregnane-3,20-dione-d₆ is the deuterium labeled 5a-Pregnane-3,20-dione. 5a-Pregnane-3,20-dione is the endogenous progesterone metabolite.

HY-W006492

5a-Pregnane-3,20-dione

Endogenous Metabolite Endocrinology Cancer

5a-Pregnane-3,20-dione is the endogenous progesterone metabolite.

*5a-Pregnane-3,20-dione*	Endogenous Metabolite	Endocrinology Cancer
5a-Pregnane-3,20-dione is the endogenous progesterone metabolite.

HY-109564

*5α-Pregnane-3β,6α-diol-20-one*	Drug Metabolite	Cancer
5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells.

HY-N4250

Periplocoside N	Others	Infection
Periplocoside N, a pregnane glycoside isolated from root powder of Periploca sepium, possesses insecticidal activities against the red imported fire ant .

HY-N12237

Condurango glycoside A0

Others Others

Condurango glycoside A0 is a pregnane ester glycoside that can be isolated from Marsdema cundurango .
HY-N11104

Glaucoside A

Others Others

Glaucoside A (compound 4), a pregnane glycoside, is a nature product that could be isolated form the roots of Cynanchum atratum .

Condurango glycoside A0	Others	Others
Condurango glycoside A0 is a pregnane ester glycoside that can be isolated from Marsdema cundurango .

Glaucoside A	Others	Others
Glaucoside A (compound 4), a pregnane glycoside, is a nature product that could be isolated form the roots of Cynanchum atratum .

HY-124830

SPA70	Others	Cancer
SPA70 is a potent and selective antagonist of *human pregnane* X receptor (hPXR), with an IC₅₀ of 540 nM (K_i**=390 nM). SPA70 can enhance the chemosensitivity of cancer cells .

HY-N1375

Qingyangshengenin	Others	Cancer
Qingyanshengenin (NSC 379666; compound 2), a pregnane glycoside, is a C21 steroidal aglycone isolated from the root of Cynanchumot ophyllum (Asclepiadaceae). Qingyanshengenin has anti-cancer activity .

HY-15371

Forskolin Maximum Cited Publications 94 Publications Verification Coleonol; Colforsin; HL 362	Organoid Adenylate Cyclase FXR Autophagy PKC	Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀ of 0.5 μM for type I adenylyl cyclase . Forskolin is also an inducer of intracellular cAMP formation . Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR . Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy .

HY-111828

TTA-A2 1 Publications Verification	Calcium Channel	Neurological Disease
TTA-A2 is a potent, selective and orally active t-type voltage gated calcium channel antagonist with reduced pregnane X receptor (PXR) activation. TTA-A2 is equally potent against the Cav3.1 (a₁G) and Cav3.2 (a₁H) channels with IC₅₀ values of 89 nM and 92 nM, respectively, at -80 and -100 mV holding potentials. TTA-A2 can be used for the research of a variety of human neurological diseases, including sleep disorders and epilepsy .

HY-N2611

Deacylmetaplexigenin

Others Others

Deacylmetaplexigenin is a pregnane glycoside isolated from Asclepias incarnate .

Deacylmetaplexigenin	Others	Others
Deacylmetaplexigenin is a pregnane glycoside isolated from Asclepias incarnate .

HY-113263

17a-Hydroxypregnenolone 1 Publications Verification	Endogenous Metabolite	Endocrinology
17a-Hydroxypregnenolone is a pregnane steroid. 17a-Hydroxypregnenolone is a prohormone in the formation of dehydroepiandrosterone (DHEA).

HY-N8956

Pachysamine M

Others Others

Pachysamine M (Compound 5) is a pregnane alkaloid. Pachysamine M is isolated from naturalPachysandra terminalisSieb. et Zucc .
HY-111202

Pyributicarb

TSH-888
Cytochrome P450 Inflammation/Immunology

Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).

Pachysamine M	Others	Others
Pachysamine M (Compound 5) is a pregnane alkaloid. Pachysamine M is isolated from naturalPachysandra terminalisSieb. et Zucc .

Pyributicarb TSH-888	Cytochrome P450	Inflammation/Immunology
Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).

HY-113263S

17a-Hydroxypregnenolone-d3	Endogenous Metabolite	Endocrinology
17a-Hydroxypregnenolone-d₃ is the deuterium labeled 17a-Hydroxypregnenolone. 17a-Hydroxypregnenolone is a pregnane steroid. 17a-Hydroxypregnenolone is a prohormone in the formation of dehydroepiandrosterone (DHEA).

HY-123632

(3S,5S)-Atorvastatin sodium salt	Cytochrome P450	Others
(3S,5S)-Atorvastatin sodium salt is a pregnane X receptor (PXR) activator and the inactive enantiomer of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor with lipid-lowering capabilities .

HY-113263R

17a-Hydroxypregnenolone (Standard)	Endogenous Metabolite	Endocrinology
17a-Hydroxypregnenolone (Standard) is the analytical standard of 17a-Hydroxypregnenolone. This product is intended for research and analytical applications. 17a-Hydroxypregnenolone is a pregnane steroid. 17a-Hydroxypregnenolone is a prohormone in the formation of dehydroepiandrosterone (DHEA).

HY-103244

CITCO 1 Publications Verification	Apoptosis	Cancer
CITCO, an imidazothiazole derivative, is a selective Constitutive androstane receptor (CAR) agonist. CITCO inhibits growth and expansion of brain tumour stem cells (BTSCs) and has an EC₅₀ of 49 nM over pregnane X receptor (PXR), and no activity on other nuclear receptors .

HY-110249

CINPA1 1 Publications Verification	Constitutive Androstane Receptor	Metabolic Disease
CINPA1 is a potent and specific inhibitor of constitutive androstane receptor (CAR) that does not activate pregnane X receptor (PXR). CINPA1 reduces CAR-mediated transcription with an IC₅₀ of ~70 nM. CINPA1 can be used as a molecular tool for understanding CAR function .

HY-B0589C

(3S,5S)-Atorvastatin	Cytochrome P450	Metabolic Disease
(3S,5S)-Atorvastatin is a inactive enantiomer of Atorvastatin. (3S,5S)-Atorvastatin can activate pregnane X receptor (PXR). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids .

HY-100793

SR12813 3 Publications Verification GW 485801	HMG-CoA Reductase (HMGCR) Autophagy	Metabolic Disease
SR12813 (GW 485801) is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, with an IC₅₀ value of 0.85 μM . SR12813 is also an efficient agonist of human pregnane X receptor (hPXR). SR12813 can strongly bind to hPXR but not to mouse PXR (mPXR) .

HY-150616

SJPYT-195

Ligands for E3 Ligase Cancer

SJPYT-195 is a cytotoxic GSPT1 degrader and can be used for PROTAC synthesis .

SJPYT-195	Ligands for E3 Ligase	Cancer
SJPYT-195 is a cytotoxic GSPT1 degrader and can be used for PROTAC synthesis .

HY-153258

CaSR antagonist-1	CaSR	Metabolic Disease
CaSR antagonist-1 is a calcium sensing receptor (CaSR) antagonist with an IC₅₀ value of 50 nM. CaSR antagonist-1 can be used for the research of disorders associated with abnormal bone or mineral homeostasis such as osteoporosis .

HY-N12239

Condurango glycoside E

Others Others

Condurango glycoside E is a glycoside compound that can be isolated from the bark extract of Marsdenia cundurango .

Condurango glycoside E	Others	Others
Condurango glycoside E is a glycoside compound that can be isolated from the bark extract of Marsdenia cundurango .

HY-16561

Resveratrol 75+ Cited Publications trans-Resveratrol; SRT501	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2	Infection Inflammation/Immunology Cancer
Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-113259

7α-Hydroxy-4-cholesten-3-one	Endogenous Metabolite	Metabolic Disease
7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1 .

HY-16561R

Resveratrol (Standard) 75+ Cited Publications trans-Resveratrol (Standard); SRT501 (Standard)	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2	Infection Inflammation/Immunology Cancer
Resveratrol (Standard) is the analytical standard of Resveratrol. This product is intended for research and analytical applications. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-16561S1

Resveratrol-13C6 trans-Resveratrol-¹³C₆; SRT501-¹³C₆	Isotope-Labeled Compounds IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2	Infection Inflammation/Immunology Cancer
Resveratrol- ¹³C₆ is the ¹³C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

HY-16561S

Resveratrol-d4 trans-Resveratrol-d₄; SRT501-d₄	Isotope-Labeled Compounds IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2	Infection Inflammation/Immunology Cancer
Resveratrol-d₄ is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

HY-113259S

7α-Hydroxy-4-cholesten-3-one-d7	Endogenous Metabolite	Metabolic Disease
7α-Hydroxy-4-cholesten-3-one-d₇ is the deuterium labeled 7α-Hydroxy-4-cholesten-3-one. 7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1[1][2].

HY-113259R

7α-Hydroxy-4-cholesten-3-one (Standard)	Endogenous Metabolite	Metabolic Disease
7α-Hydroxy-4-cholesten-3-one (Standard) is the analytical standard of 7α-Hydroxy-4-cholesten-3-one. This product is intended for research and analytical applications. 7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W006492

*5a-Pregnane-3,20-dione*	Classification of Application Fields Source classification Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Steroids Cancer	Endogenous Metabolite
5a-Pregnane-3,20-dione is the endogenous progesterone metabolite.

HY-109564

*5α-Pregnane-3β,6α-diol-20-one*	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Drug Metabolite
5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells.

HY-N4250

Periplocoside N	Infection other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids	Others
Periplocoside N, a pregnane glycoside isolated from root powder of Periploca sepium, possesses insecticidal activities against the red imported fire ant .

HY-N12237

Condurango glycoside A0	Apocynaceae Structural Classification Marsdenia cundurango Rchb.f. Polysaccharides Source classification Plants Saccharides	Others
Condurango glycoside A0 is a pregnane ester glycoside that can be isolated from Marsdema cundurango .

HY-N11104

Glaucoside A	Apocynaceae Structural Classification Source classification Plants Vincetoxicum atratum (Bunge) Morren et Decne. Steroids	Others
Glaucoside A (compound 4), a pregnane glycoside, is a nature product that could be isolated form the roots of Cynanchum atratum .

HY-N1375

Qingyangshengenin	Monophenols Classification of Application Fields Source classification Asclepiadaceae Phenols Cynanchum otophyllum Schneid． Plants Disease Research Fields Steroids Cancer	Others
Qingyanshengenin (NSC 379666; compound 2), a pregnane glycoside, is a C21 steroidal aglycone isolated from the root of Cynanchumot ophyllum (Asclepiadaceae). Qingyanshengenin has anti-cancer activity .

HY-15371

Forskolin Maximum Cited Publications 94 Publications Verification Coleonol; Colforsin; HL 362	Structural Classification Classification of Application Fields Terpenoids Labiatae Source classification Metabolic Disease Diterpenoids Plants Inflammation/Immunology Disease Research Fields Endocrinology Gochnatia polymorpha (Less) Cabr.	Organoid Adenylate Cyclase FXR Autophagy PKC
Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀ of 0.5 μM for type I adenylyl cyclase . Forskolin is also an inducer of intracellular cAMP formation . Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR . Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy .

HY-N2611

Deacylmetaplexigenin	other families Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields Steroids	Others
Deacylmetaplexigenin is a pregnane glycoside isolated from Asclepias incarnate .

HY-113263

17a-Hydroxypregnenolone 1 Publications Verification	Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Classification of Application Fields Source classification Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Endocrinology Steroids	Endogenous Metabolite
17a-Hydroxypregnenolone is a pregnane steroid. 17a-Hydroxypregnenolone is a prohormone in the formation of dehydroepiandrosterone (DHEA).

HY-N8956

Pachysamine M	Structural Classification Alkaloids Buxaceae Other Alkaloids Source classification Pachysandra terminalis Siebold & Zucc. Plants	Others
Pachysamine M (Compound 5) is a pregnane alkaloid. Pachysamine M is isolated from naturalPachysandra terminalisSieb. et Zucc .

HY-113263R

17a-Hydroxypregnenolone (Standard)	Structural Classification Immune System Disorder Classification of Application Fields Source classification Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Endocrinology Steroids	Endogenous Metabolite
17a-Hydroxypregnenolone (Standard) is the analytical standard of 17a-Hydroxypregnenolone. This product is intended for research and analytical applications. 17a-Hydroxypregnenolone is a pregnane steroid. 17a-Hydroxypregnenolone is a prohormone in the formation of dehydroepiandrosterone (DHEA).

HY-N12239

Condurango glycoside E	Apocynaceae Marsdenia cundurango Rchb.f. Source classification Plants	Others
Condurango glycoside E is a glycoside compound that can be isolated from the bark extract of Marsdenia cundurango .

HY-16561

Resveratrol 75+ Cited Publications trans-Resveratrol; SRT501	Structural Classification Classification of Application Fields Anti-aging Source classification Vitis vinifera cv. Zalema Plants Vitaceae Infection Microorganisms Functional Molecules Sunscreen Research of Health Products Phenols Polyphenols Cosmetic Research Inflammation/Immunology Disease Research Fields Cancer	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-113259

7α-Hydroxy-4-cholesten-3-one	Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1 .

HY-16561R

Resveratrol (Standard) 75+ Cited Publications trans-Resveratrol (Standard); SRT501 (Standard)	Infection Functional Molecules Classification of Application Fields Sunscreen Anti-aging Source classification Research of Health Products Cosmetic Research Plants Inflammation/Immunology Disease Research Fields Cancer	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
Resveratrol (Standard) is the analytical standard of Resveratrol. This product is intended for research and analytical applications. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-113259R

7α-Hydroxy-4-cholesten-3-one (Standard)	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
7α-Hydroxy-4-cholesten-3-one (Standard) is the analytical standard of 7α-Hydroxy-4-cholesten-3-one. This product is intended for research and analytical applications. 7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1 .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701396

	PXR Protein, Human NR1I2; Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; pregnane X receptor; Steroid and xenobiotic receptor; SXR	Human	E. coli
	The PXR protein is a nuclear receptor that acts as a multifunctional transcription factor activated by a variety of endogenous and exogenous compounds. It regulates genes involved in the metabolism and secretion of substances, responding to ligands such as rifampicin, hypericin, gugulin, colupulone, isoflavones, pregnenolone and progesterone. PXR Protein, Human is the recombinant human-derived PXR protein, expressed by E. coli , with tag free. The total length of PXR Protein, Human is 305 a.a., .

HY-P701397

	PXR Protein, Human (His) NR1I2; Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; pregnane X receptor; Steroid and xenobiotic receptor; SXR	Human	E. coli
	The PXR protein is a nuclear receptor that acts as a multifunctional transcription factor activated by a variety of endogenous and exogenous compounds. It regulates genes involved in the metabolism and secretion of substances, responding to ligands such as rifampicin, hypericin, gugulin, colupulone, isoflavones, pregnenolone and progesterone. PXR Protein, Human (His) is the recombinant human-derived PXR protein, expressed by E. coli , with N-6*His labeled tag. The total length of PXR Protein, Human (His) is 305 a.a., .

Cat. No.	Product Name	Chemical Structure

HY-W006492S

5a-Pregnane-3,20-dione-d6

5a-Pregnane-3,20-dione-d₆ is the deuterium labeled 5a-Pregnane-3,20-dione. 5a-Pregnane-3,20-dione is the endogenous progesterone metabolite.

HY-113263S

17a-Hydroxypregnenolone-d3
17a-Hydroxypregnenolone-d₃ is the deuterium labeled 17a-Hydroxypregnenolone. 17a-Hydroxypregnenolone is a pregnane steroid. 17a-Hydroxypregnenolone is a prohormone in the formation of dehydroepiandrosterone (DHEA).

HY-16561S

Resveratrol-d4

Resveratrol-d₄ is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

HY-113259S

7α-Hydroxy-4-cholesten-3-one-d7

7α-Hydroxy-4-cholesten-3-one-d₇ is the deuterium labeled 7α-Hydroxy-4-cholesten-3-one. 7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1[1][2].

HY-16561S1

Resveratrol-13C6

Resveratrol- ¹³C₆ is the ¹³C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

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