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Results for "

prenylated

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (3) Aldose Reductase (1) AMPK (1) Apoptosis (8) ATP Synthase (1) Aurora Kinase (1) Bacterial (4) Bcl-2 Family (1) Beta-secretase (1) Biochemical Assay Reagents (1) Caspase (1) Cholinesterase (ChE) (1) COX (3) DNA/RNA Synthesis (1) Drug-Linker Conjugates for ADC (2) Endogenous Metabolite (2) ERK (2) Estrogen Receptor/ERR (2) GABA Receptor (1) Glucosidase (1) HSV (1) ICMT (1) JNK (1) Mitochondrial Metabolism (1) Monoamine Oxidase (1) Neurokinin Receptor (1) NF-κB (3) NO Synthase (2) Oxidative Phosphorylation (1) p38 MAPK (2) Parasite (1) PERK (1) Phosphodiesterase (PDE) (3) Reactive Oxygen Species (2) Sirtuin (1) STAT (1) TNF Receptor (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (2) Endocrinology (3) Infection (7) Inflammation/Immunology (8) Metabolic Disease (4) Neurological Disease (2)

By Targets:

Akt (3)

Aldose Reductase (1)

AMPK (1)

Apoptosis (8)

ATP Synthase (1)

Aurora Kinase (1)

Bacterial (4)

Bcl-2 Family (1)

Beta-secretase (1)

Biochemical Assay Reagents (1)

Caspase (1)

Cholinesterase (ChE) (1)

COX (3)

DNA/RNA Synthesis (1)

Drug-Linker Conjugates for ADC (2)

Endogenous Metabolite (2)

ERK (2)

Estrogen Receptor/ERR (2)

GABA Receptor (1)

Glucosidase (1)

HSV (1)

ICMT (1)

JNK (1)

Mitochondrial Metabolism (1)

Monoamine Oxidase (1)

Neurokinin Receptor (1)

NF-κB (3)

NO Synthase (2)

Oxidative Phosphorylation (1)

p38 MAPK (2)

Parasite (1)

PERK (1)

Phosphodiesterase (PDE) (3)

Reactive Oxygen Species (2)

Sirtuin (1)

STAT (1)

TNF Receptor (1)

By Research Areas:

Cancer (12)

Cardiovascular Disease (2)

Endocrinology (3)

Infection (7)

Inflammation/Immunology (8)

Metabolic Disease (4)

Neurological Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N3776

Dorsmanin A

Others Others

Dorsmanin A is a prenylated flavonoid from the twigs of Dorstenia mannii .
HY-N3180

Norbraylin

Phosphodiesterase (PDE) Inflammation/Immunology

Norbraylin, a natural prenylated coumarin, is a PDE4D2 inhibitor with an IC₅₀ value of 7.15 μM .
HY-N3853

Erysubin A

Others Others

Erysubin A is a prenylated isoflavonoid that can be isolated from Erinacea anthyllis .

Dorsmanin A	Others	Others
Dorsmanin A is a prenylated flavonoid from the twigs of Dorstenia mannii .

Norbraylin	Phosphodiesterase (PDE)	Inflammation/Immunology
Norbraylin, a natural prenylated coumarin, is a PDE4D2 inhibitor with an IC₅₀ value of 7.15 μM .

Erysubin A	Others	Others
Erysubin A is a prenylated isoflavonoid that can be isolated from Erinacea anthyllis .

HY-N3257

Millewanin G	Estrogen Receptor/ERR	Endocrinology
Millewanin G is a prenylated isoflavonoid with antiestrogenic activity (IC₅₀=29 μM). Millewanin G can be isolated from the leaves of M. pachycarpa cultivated in Japan .

HY-N8097

Kushenol W	Bacterial	Infection
Kushenol W is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol W has antimicrobial effect, with a MIC of 10 μg/mL for Staphylococcus aureus .

HY-122966

Desmethylxanthohumol 1 Publications Verification	Apoptosis	Cancer
Desmethylxanthohumol is a prenylated hydroxychalcone isolated from hop cones (Humulus lupulus L.). Desmethylxanthohumol is a powerful apoptosis inducing agent. Desmethylxanthohumol has antiplasmodial, antiproliferative, and antioxidant bioactivities .

HY-119552

Acetylaszonalenin LL-S490β	Endogenous Metabolite Neurokinin Receptor	Neurological Disease
Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [ ³H]-SP binding to human astrocytoma cells with a K_i of 170 μM .

HY-N6084

Humulone α-Lupulic acid	COX GABA Receptor Apoptosis	Cardiovascular Disease
Humulone (α-Lupulic acid), a prenylated phloroglucinol derivative, is a potent cyclooxygenase-2 (COX-2) inhibitor. Humulone acts as a positive modulator of GABA_A receptor at low micromolar concentrations. Humulone is an inhibitor of bone resorption. Humulone possesses antioxidant, anti-angiogenic and apoptosis-inducing properties .

HY-N10952

Epicornuin F	Others	Cancer
Epicornuin F is a prenylated flavonoid. Epicornuin F can be isolated from the leaves of Epimedium brevicornu. Epicornuin F has the cytotoxic activity against HepG2 cells with an IC₅₀ value of 33.4 μM. Epicornuin F can be used for the research of cancer .

HY-N2693

6,8-Diprenylorobol	Apoptosis Reactive Oxygen Species Caspase Akt ERK JNK p38 MAPK Bcl-2 Family	Cancer
6,8-Diprenylorobol, a prenylated isoflavone, is a nature product that could be isolated from the leaves of Cudrania tricuspidata. 6,8-Diprenylorobol antiproliferative effect and induces apoptosis through activation of p53 and generation of ROS .

HY-N3920

Gancaonin G	Bacterial	Infection
Gancaonin G is a 6-prenylated isoflavanone that can be isolated from Glycyrrhiza uralensis. Gancaonin G has antibacterial activity against Streptococcus mutants and MRSA strains .

HY-N4316

Flemiphilippinin A

Others Endocrinology

Flemiphilippinin A is a prenylated isoflavone that can be isolated from Flemingia philippinensis .
HY-N11047

7-O-methylepimedonin G

Others Others

7-O-methylepimedonin G is a prenylated 2-phenoxychromone that can be isolated from Epimedium brevicornum .
HY-N8824

Maackiaflavanone

Others Others

Maackiaflavanone (compound 4) is a kind of prenylated flavanone. Maackia can be isolated from M. amurensi.
HY-N3854

Erysubin B

Others Others

Erysubin B is a prenylated isoflavonoid, which can be isolated from the whole plant (roots and aerial parts) of Erinacea anthyllis .

Flemiphilippinin A	Others	Endocrinology
Flemiphilippinin A is a prenylated isoflavone that can be isolated from Flemingia philippinensis .

7-O-methylepimedonin G	Others	Others
7-O-methylepimedonin G is a prenylated 2-phenoxychromone that can be isolated from Epimedium brevicornum .

Maackiaflavanone	Others	Others
Maackiaflavanone (compound 4) is a kind of prenylated flavanone. Maackia can be isolated from M. amurensi.

Erysubin B	Others	Others
Erysubin B is a prenylated isoflavonoid, which can be isolated from the whole plant (roots and aerial parts) of Erinacea anthyllis .

HY-W749694

Cannflavin B Canniflavone	Others	Inflammation/Immunology
Cannflavin B is a prenylated flavone, which can be isolated from Cannabis sativa L. Cannflavin B has anti-inflammatory activity .

HY-N8095

Kushenol N	Others	Cardiovascular Disease
Kushenol N is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol N has anti-allergic and vasorelaxation activities .

HY-129605

Ferulenol	Oxidative Phosphorylation Mitochondrial Metabolism	Infection
Ferulenol, a sesquiterpene prenylated coumarin derivative, specifically inhibits succinate ubiquinone reductase at the level of the ubiquinonecycle. Ferulenol shows good antimycobacterial activity and haemorrhagic action .

HY-N0622

Morusin 4 Publications Verification Mulberrochromene	NF-κB STAT Bacterial	Infection Inflammation/Immunology Cancer
Morusin is a prenylated flavonoid isolated from Morus alba Linn. with various biological activities, such as antitumor, antioxidant, and anti-bacteria property. Morusin could inhibit NF-κB and STAT3 activity.

HY-N3737

Derrone	Aurora Kinase PERK Reactive Oxygen Species	Cancer
Derrone, a prenylated isoflavones, is an Aurora kinase inhibitor, with IC₅₀ values of 6 and 22.3 μM against Aurora B and Aurora A, respectively. Derrone shows anti-tumor activity .

HY-118563

Farnesylthioacetic acid	Biochemical Assay Reagents	Others
S-Farnesyl thioacetic acid is an analog of S-farnesyl cysteine, which is a prenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase) competitive inhibitors. It also inhibits the methylation of farnesylated and geranylgeranylated substrates.

HY-N11841

Mortatarin G	Glucosidase	Metabolic Disease
Mortatarin G (compound 3) is a prenylated flavonoid, that can be isolated from mulberry leaves. Mortatarin G exhibits good α-glucosidase inhibitory activity, with an IC₅₀ of 20.4±1.4 μM .

HY-133021

Arazine N-Acetyl-S-farnesyl-L-cysteine	Others	Inflammation/Immunology
Arazine (N-Acetyl-S-farnesyl-L-cysteine) is a cell-permeable modulator of G protein and G-protein coupled receptor signaling. Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site .

HY-121381

Kuraridine	Phosphodiesterase (PDE)	Others
Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens. Kuraridine has an inhibitory effect on cGMP specific phosphodiesterase type 5 (PDE5) (IC₅₀=0.64 μM) .

HY-125612

Artonin E 5'-Hydroxymorusin	Apoptosis	Cancer
Artonin E (5'-Hydroxymorusin) is a known prenylated flavonoid that induces apoptosis and arrests the cell cycle in S phase. Artonin E can induce anti-proliferative effects through mitochondrial pathway dysregulation and can be used in cancer research .

HY-P3350

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

HY-N3743

Erythrivarone A

Dihydroalpinumisoflavone
Others Others

Erythrivarone A is an isoflavone that can be isolated from the stem bark of Erythrina variegate .

Erythrivarone A Dihydroalpinumisoflavone	Others	Others
Erythrivarone A is an isoflavone that can be isolated from the stem bark of Erythrina variegate .

HY-N3426

Kazinol B	NO Synthase Akt AMPK	Metabolic Disease
Kazinol B, a prenylated flavan with a dimethyl pyrane ring, is an inhibitor of nitric oxide (NO) production. Kazinol B improves insulin sensitivity by enhancing glucose uptake via the insulin-Akt signaling pathway and AMPK activation. Kazinol B has the potential for diabetes mellitus research .

HY-N2554

Osthenol Ostenol	Monoamine Oxidase	Neurological Disease
Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (K_i=0.26 µM). Osthenol potently inhibits recombinant hMAO-A with an IC₅₀ of 0.74 µM and shows a high selectivity index for hMAO-A versus hMAO-B .

HY-N8265

Abyssinone V	HSV DNA/RNA Synthesis ATP Synthase	Infection
Abyssinone V is a prenylated flavonoid with predicted anti-viral activity. Abyssinone V can be isolated from the stem bark of Erythrina melanacantha. Abyssinone V possesses good pharmacodynamics properties. Abyssinone V is predicted to be antivirals including anti-herpes (HSV) agent, with mechanisms comprising inhibition of polymerase, ATPase and membrane integrity .

HY-125538

Deoxybrevianamide E	Endogenous Metabolite	Inflammation/Immunology
Deoxybrevianamide E, an indole alkaloid, is a biosynthetic precursor for advanced metabolites isolated from the marine-derived Aspergillus sp. .

HY-N6009

8-Deoxygartanin	Parasite NF-κB	Infection
8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE) . 8-Deoxygartanin exhibits antiplasmodial activity with an IC₅₀ of 11.8 μM for the W2 strain of Plasmodium falciparum . 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC₅₀ of 11.3 μM .

HY-126109

(±)-8-Prenylnaringenin	Estrogen Receptor/ERR Apoptosis	Metabolic Disease Endocrinology Cancer
(±)-8-Prenylnaringenin, a natural prenylated flavonoid, is a potent phytoestrogen. (±)-8-Prenylnaringenin is an orally active selective estrogen receptor modulator (SERM) (Estrogen Receptor/ERR) that inhibits ERα and ERβ with IC₅₀s of 57 nM and 68 nM, respectively. (±)-8-Prenylnaringenin has anticancer effects, and can be used for osteoporosis research .

HY-161144

AKT-IN-21	Akt Apoptosis	Cancer
AKT-IN-21 (compound C36) is a potent AKT inhibitor with broad-spectrum cytotoxicity and anticancer activity. AKT-IN-21 also blocks the cell cycle and induces apoptosis of cancer cells by down-regulating the PI3K/AKT pathway .

HY-N2284

Sophoflavescenol	Cholinesterase (ChE) Beta-secretase Phosphodiesterase (PDE)	Cancer
Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC₅₀ of 0.013 μM against Phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC₅₀s of 0.30 µM, 0.17 µM, 17.89 µg/mL, 10.98 µM, 8.37 µM and 8.21 µM, respectively.

HY-157116

ICMT-IN-48	ICMT	Cancer
ICMT-IN-48 (compound 1) is an ICMT inhibitor that is competitive (Km=13 μM) for the prenylated methyl acceptor, the first substrate of ICMT. ICMT-IN-48 inhibits ICMT activity with IC₅₀s affected by the concentration of the second substrate S-adenosylmethinine (SAM), and the IC₅₀s are 3.5 μM (1×Km SAM) and 2.3 μM (10×Km SAM), respectively .

HY-N3716

Dehydroglyasperin D	Aldose Reductase COX	Metabolic Disease Inflammation/Immunology
Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC₅₀: 62.4 μM and 176.2 μM respectively). Dehydroglyasperin D has anti-obesity, antioxidant effects. Dehydroglyasperin D shows anti-inflammatory activity by inhibiting COX-2 expression and the MLK3 signaling pathway. Dehydroglyasperin D also inhibits melanin synthesis. Dehydroglyasperin D is a prenylated flavonoid that can be isolated from Glycyrrhiza uralensi .

HY-N8477

Isolupalbigenin

NO Synthase Inflammation/Immunology

Isolupalbigenin is an inhibitor of NO. Isolupalbigenin has anti-proliferative activity on HL-60 cells with an IC₅₀ of 5.1 μM .
HY-N2683

5-O-Methylnaringenin

Others Others

5-O-Methylnaringenin is a flavonoid compound. 5-O-Methylnaringenin is isolated from chloroacetic acid .

Isolupalbigenin	NO Synthase	Inflammation/Immunology
Isolupalbigenin is an inhibitor of NO. Isolupalbigenin has anti-proliferative activity on HL-60 cells with an IC₅₀ of 5.1 μM .

5-O-Methylnaringenin	Others	Others
5-O-Methylnaringenin is a flavonoid compound. 5-O-Methylnaringenin is isolated from chloroacetic acid .

HY-N10009

Cudraflavone B	NF-κB TNF Receptor COX ERK p38 MAPK Sirtuin	Inflammation/Immunology
Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells .

HY-145736A

β-Glucuronide-dPBD-PEG5-NH2 TFA	Drug-Linker Conjugates for ADC Apoptosis	Cancer
β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 TFA can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 TFA has antitumor activity .

HY-145736

β-Glucuronide-dPBD-PEG5-NH2	Drug-Linker Conjugates for ADC Apoptosis	Cancer
β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 has antitumor activity .

Farnesylthioacetic acid	Biochemical Assay Reagents
S-Farnesyl thioacetic acid is an analog of S-farnesyl cysteine, which is a prenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase) competitive inhibitors. It also inhibits the methylation of farnesylated and geranylgeranylated substrates.

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

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