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Pathways Recommended: Others

Results for "productlist/Others" in MCE Product Catalog:

2387

Inhibitors & Agonists

28

Screening Libraries

270

Dye Reagents

80

Biochemical Assay Reagents

222

Peptides

1

Inhibitory Antibodies

1083

Natural
Products

Cat. No. Product Name Target Research Area
  • HY-B0456
    Riboflavin

    Vitamin B2; E101

    Endogenous Metabolite Others
    Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
  • HY-B2220
    Cellulase

    Others Others
    Cellulase is an enzyme catalyzing the hydrolysis of certain linkages in cellulose and other carbohydrates.
  • HY-D0887
    Disodium 5'-inosinate

    IMP disodium salt; Disodium inosinate

    Others Others
    Disodium 5'-inosinate, obtained from bacterial fermentation of sugars, is as a food additive and often found in a variety of other snacks.
  • HY-B0927
    Hydrastine

    (-)-β-Hydrastine; (1R,9S)-β-Hydrastine

    Others Others
    Hydrastine is a natural alkaloid which is present in Hydrastis canadensis and other plants of the ranunculaceae family.
  • HY-B2132
    Tryptamine

    Endogenous Metabolite Others
    Tryptamine is a monoamine alkaloid, similar to other trace amines, is believed to play a role as a neuromodulator or neurotransmitter.
  • HY-13101
    MCOPPB triHydrochloride

    MCOPPB 3HCl

    Opioid Receptor Others
    MCOPPB 3Hcl is a nociceptin receptor agonist with pKi of 10.07; weaker activity at other opioid receptors.
  • HY-N0467
    Rebaudioside C

    Dulcoside B

    Others Others
    Rebaudioside C(Dulcoside B) is used as natural sweeteners to diabetics and others on carbohydrate-controlled diets.
  • HY-N0657
    Pinoresinol Diglucoside

    Others Others
    Pinoresinol Diglucoside is one of the major lignans with various pharmacological activities which could be isolated from Duzhong and other plant species.
  • HY-W015806
    3-Pyridineacetic acid

    Endogenous Metabolite Others
    3-Pyridineacetic acid is a higher homologue of nicotinic acid, a breakdown product of nicotine (and other tobacco alkaloids).
  • HY-12779
    Cyantraniliprole

    HGW-86

    Others Others
    Cyantraniliprole(HGW-86) is an insecticide of the ryanoid class; has activity against pests such as Diaphorina citri that have developed resistance to other classes insecticides.
  • HY-B2045
    Benfluralin

    Others Others
    Benfluralin is a kind of herbicide and an agrochemical which can be used as a pre-emergence herbicide used for the control of grass and other weeds in a range of food and non-food crops.
  • HY-W012999
    Tiglic acid

    Others Others
    Tiglic acid is a monocarboxylic unsaturated organic acid found in croton oil and in several other natural products. Tiglic aci has a role as a plant metabolite.
  • HY-15979
    H-89

    Protein kinase inhibitor H-89

    PKA Autophagy Others
    H-89 is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC50 of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase, and others kinases.
  • HY-B0932
    Levocarnitine propionate hydrochloride

    L-Propionylcarnitine chloride; ST-261

    Others Others
    Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride; ST-261) is used to treat the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases.
  • HY-B0891
    17-Hydroxyprogesterone

    17α-Hydroxyprogesterone; 17-OHP

    Progesterone Receptor Endogenous Metabolite Others
    17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
  • HY-14350
    AC-55541

    Protease-Activated Receptor (PAR) Others
    AC-55541 is a highly selective protease-activated receptor 2 (PAR2) agonist (pEC50=6.7), displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. AC-55541 has pEC50 values of 5.9 and 6.6 in PI hydrolysis assays and Ca 2+ mobilization assays and exhibits pronociceptive activity in vivo.
  • HY-N6681
    15-Acetoxyscirpenol

    Apoptosis Caspase Others
    15-acetoxyscirpenol, one of acetoxyscirpenol moiety mycotoxins (ASMs), strongly induces apoptosis and inhibits Jurkat T cell growth in a dose-dependent manner by activating other caspases independent of caspase-3.
  • HY-B1234
    Octinoxate

    Octyl methoxycinnamate

    Others Others
    Octinoxate is an organic compound that is an ingredient in some sunscreens and lip balms, primarily used is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage.
  • HY-113081
    1-Methyladenosine

    Endogenous Metabolite Others
    1-Methyladenosine is an RNA modification originating essentially from two different reaction types, one catalyzed by enzymes and the other the result of the reaction of RNA with certain alkylating agents.
  • HY-N2044
    Methyl 3,4,5-trimethoxybenzoate

    Others Others
    Methyl 3,4,5-trimethoxybenzoate can be synthesized from Gallic acid. Methyl 3,4,5-trimethoxybenzoate is mainly used in the production of Trimethoprim (TMP), Sulfa synergistic intermediates, and many other agents.
  • HY-17518
    Valifenalate

    IR5885; Valiphenal

    Bacterial Others
    Valifenalate(IR5885; Valiphenal), which is approved for application on high-value crops such as grapes, tomatoes and other vegetables, is effective against various types of mildew and is currently marketed primarily under the Valis moniker; insecticide agent.
  • HY-128918
    SIS17

    HDAC Others
    SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM, inhibits the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.
  • HY-B0907
    Resorcinol

    Resorcin; 1,3-Benzenediol

    Others Inflammation/Immunology
    Resorcinol is an antiseptic and a disinfectant, and a chemical intermediate for the production of many other pharmaceuticals,is used to treat acne, seborrheic dermatitis, eczema, psoriasis, and other skin disorders.
  • HY-B1248
    Chlorhexidine

    Bacterial Infection
    Chlorhexidine is an antibacterial used as an antiseptic and for other applications.
  • HY-B1145
    Chlorhexidine dihydrochloride

    Bacterial Infection
    Chlorhexidine dihydrochloride is an antibacterial, used as an antiseptic and for other applications.
  • HY-W009884
    Acetosyringone

    Others Others
    Acetosyringone is a phenolic compound from wounded plant cells, enables virA gene which encodes a membrane-bound kinase to phosphorylate itself and activate the virG gene product, which stimulates the transcription of other vir genes and itself. Acetosyringone enhances efficient Dunaliella transformation of Agrobacterium strains.
  • HY-N2581
    Phytic acid sodium salt

    myo-Inositol, hexakis(dihydrogen phosphate) sodium salt; Inositol hexaphosphate sodium salt

    Others Others
    Phytic acid sodium salt (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphat) is often present in legume seeds with antinutritional effects. Phytic acid sodium salt is a [PO4] 3- storage depot and precursor for other inositol phosphates and pyrophosphates. phytic acid is hydrolyzed by phytases in a stepwise manner in the plant.
  • HY-Y0949
    Methyl 2-furoate

    Methyl furan-2-carboxylate

    Others Others
    Methyl 2-furoate (Methyl furan-2-carboxylate) is a building block in chemical synthesis. A flavoring agent in food. Found in cranberries, guava fruits, raisins and other fruits. Also present in baked potato, roasted filberts, roasted peanut, tomatoes, coffee, cocoa, okra, etc.
  • HY-103447
    Zearalenone

    Mycotoxin F2; Toxin F2

    Others Others
    Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts.
  • HY-113957
    MPI_5a

    HDAC Others
    MPI_5a is a potent and selective HDAC6 inhibitor (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms. MPI_5a inhibits acyl-tubulin accumulation in cells with an IC50 value of 210 nM.
  • HY-16968
    SW033291

    15-PGDH Others
    SW033291 is a potent and high-affinity inhibitor of 15-PGDH with a Ki of 0.1 nM. SW033291 increases prostaglandin PGE2 levels in bone marrow and other tissues. SW033291 also promotes tissue regeneration.
  • HY-125829
    Erythropterin

    Others Others
    Erythropterin is a Pterin derivative that belongs in a group of heterocyclic compounds that are frequently found in biological systems. Pterin derivatives are responsible for the characteristic warning coloration of some Heteroptera and other insects, signaling noxiousness or unpalatability and are used to discourage potential predators from attacking.
  • HY-115521
    Jarin-1

    Others Others
    Jarin-1 is a jasmonic acid-amido synthetase (JAR1) inhibitor with an IC50 of 3.8 μM. Jarin-1 specific inhibits bioactive JA (jasmonoyl-isoleucine, JA-Ile) biosynthesis in Arabidopsis and other plants.
  • HY-N2086
    Ethyl palmitate

    Ethyl hexadecanoate

    Others Others
    Ethyl palmitate, a fatty acid ethyl ester (FAEE), shows a marked preference for the synthesis of ethyl palmitate and ethyl oleate over other FAEEs in human subjects after ethanol consumption. Ethyl palmitate is used as a hair- and skin-conditioning agent.
  • HY-122697
    ML418

    Potassium Channel Others
    ML418 is the first potent, selective and CNS penetrating blocker of Kir7.1 potassium channel (IC50, 310 nM), which also potently inhibits Kir6.2/SUR1, and exhibits superior selectivity over other Kir channels.
  • HY-107642
    MA-2029

    Motilin Receptor Others
    MA-2029 is a selective, orally active, and competitive motilin receptor antagonist (IC50=4.9 nM). MA-2029 is selective for the motilin receptor over various other receptors and ion channels. MA-2029 may be useful for gastrointestinal disorders associated with disturbed gastrointestinal motility.
  • HY-16564
    Deferasirox (Fe3+ chelate)

    Ferroptosis Bacterial Others
    Deferasirox Fe3+ chelate is a rationally-designed oral iron chelator; its main use is to reduce chronic iron overload in patients who are receiving long-term blood transfusions for conditions such as beta-thalassemia and other chronic anemias.
  • HY-117889
    PARP14 inhibitor H10

    PARP Apoptosis Others
    PARP14 inhibitor H10, compound H 10, is a selective inhibitor against PARP14 (IC50=490 nM), over other PARPs (≈24 fold over PARP1). PARP14 inhibitor H10 induces caspase-3/7-mediated cell apoptosis.
  • HY-13802
    SC-514

    GK 01140

    IKK Cancer
    SC-514 is a selective IKK-2 inhibitor (IC50=11.2±4.7 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.
  • HY-N2510
    Myristicin

    Myristicine

    5-HT Receptor Neurological Disease
    Myristicine  act as a serotonin receptor antagonist, a weak monamine oxidase (MAO) inhibitor. Myristicine is the main component of nutmeg essential oil from Myristica fragrans Houtt. Myristicine abuse produce hallucinogenic effects, organ damage, deliriumand others.
  • HY-B0894
    Resorcinol monoacetate

    Acetylresorcinol; Resorcin monoacetate

    Others Inflammation/Immunology
    Resorcinol monoacetate is an antiseptic and a disinfectant, is a chemical intermediate for the production of many other pharmaceuticals, and has the potential for acne, seborrheic dermatitis, eczema, psoriasis, and other skin disorders treatment.
  • HY-W017389
    Xanthine

    Endogenous Metabolite Inflammation/Immunology
    Xanthine is a purine base found in most human body tissues and fluids and in other organisms.
  • HY-B1870
    Metaldehyde

    Others Infection
    Metaldehyde is commonly used as a pesticide against slugs, snails, and other gastropods.
  • HY-B1207
    Urethane

    Ethyl carbamate; Carbamic acid ethyl ester; Ethylurethane

    Others Cancer
    Urethane has been used as an antineoplastic agent and for other medicinal purposes
  • HY-112373
    Aurora Kinase Inhibitor 3

    Aurora Kinase Others
    Aurora Kinase Inhibitor 3 is a strong and selective Aurora A kinase inhibitor with an IC50 of 42 nM, and weakly inhibits EGFR with an IC50>10 μM. Aurora Kinase Inhibitor 3 has a binding mode with the cyclopropanecarboxylic acid moiety directed towards the solvent exposed region of the ATP-binding pocket, and several induced structural changes in the active-site compared with other published AIK structures.
  • HY-133012
    GFB-8438

    TRP Channel Others
    GFB-8438 is a potent and subtype selective TRPC5 inhibitor, with IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively. GFB-8438 shows excellent selectivity against TRPC6, other TRP family members, NaV 1.5, as well as limited activity against the hERG channel. GFB-8438 protects mouse podocytes from injury induced by protamine sulfate model.
  • HY-P1746A
    Protein Kinase C (19-31) (TFA)

    PKC (19-31) (TFA)

    PKC Others
    Protein Kinase C (19-31) TFA, a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, is used as protein kinase C substrate peptide for testing the protein kinase C activity. Protein kinase C (PKC) TFA is involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins.
  • HY-12270
    T-5224

    MMP Others
    T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription.
  • HY-W011727A
    Pyridoxal 5'-​phosphate monohydrate

    Pyridoxal phosphate monohydrate

    Others Others
    Pyridoxal 5'-phosphate hydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate hydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′‐phosphate (PMP).
  • HY-W011500
    TCEP hydrochloride

    Tris(2-​carboxyethyl)​phosphine hydrochloride

    Others Others
    TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry.
  • HY-P1746
    Protein Kinase C 19-31

    PKC (19-31)

    PKC Others
    Protein Kinase C (19-31), a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, is used as protein kinase C substrate peptide for testing the protein kinase C activity. Protein kinase C (PKC) is involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins.
  • HY-119309
    Sucrose octaacetate

    Others Others
    Sucrose octaacetate is an acetylated derivative of sucrose with an intensely bitter tasting and can be used as bitter tasting surrogate. Sucrose octaacetate can be used as food additive and also used as an adhesive and plasticizer. Sucrose octaacetate also used in many pesticides, insecticides, and other toxic products as a deterrent to accidental poisoning. Sucrose octaacetate can also be used as an in situ seed and a soft template to synthesize polyaniline (PANI) nanofibers.
  • HY-10406
    Talmapimod

    SCIO-469

    p38 MAPK Autophagy Cancer
    Talmapimod (SCIO-469) is an orally active, selective, and ATP-competitive p38α inhibitor with IC50 of 9 nM, shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs.
  • HY-B1975
    Dithianon

    Fungal Reactive Oxygen Species Infection
    Dithianon is a broad-spectrum anthraquinone fungicide with good adherence to the surface of leaves and fruits. Dithianon is used to control several several fungal of some fruits and vegetables, as anthracnose (Colletotrichum sp., Elsinoe ampelina), mildew (Plasmopara viticola), phomopsis (Phomopsis viticola), among others.
  • HY-101877
    Statine

    (3S,4S)-Statine; (S,S)-Statine

    Others Endocrinology
    Statine is an unusual amino acid that occurs twice in the sequence of pepstatin, a protease inhibitor that is active against pepsin and other acid proteases.
  • HY-16503
    Treosulfan

    NSC 39069; Treosulphan

    DNA Alkylator/Crosslinker Cancer
    Treosulfan (NSC 39069;Treosulphan) is an alkylating agent with activity in ovarian cancer and other solid tumor types.
  • HY-N0287
    Lycopene

    Reactive Oxygen Species Cardiovascular Disease Cancer
    Lycopene is naturally occurring carotenoids found in tomato, tomato products, and in other red fruits and vegetables; exhibits antioxidant effects.
  • HY-17566
    Capreomycin sulfate

    Bacterial Infection
    Capreomycin sulfate is a peptide antibiotic, commonly grouped with the aminoglycosides, which is given in combination with other antibiotics for MDR-tuberculosis.
  • HY-U00352
    PDE IV-IN-1

    Phosphodiesterase (PDE) Inflammation/Immunology
    PDE IV-IN-1 is an inhibitor of phosphodiesterase IV, used for the research of asthma, COPD or other inflammatory diseases.
  • HY-13909
    RGFP966

    HDAC Cancer
    RGFP966 is a highly selective HDAC3 inhibitor with an IC50 of 80 nM and shows no inhibition to other HDACs at concentrations up to 15 μM.
  • HY-B1896B
    Piperaquine tetraphosphate tetrahydrate

    Parasite Infection
    Piperaquine tetraphosphate tetrahydrate is a potent anti-parasites agent, widely used in combination with other antimalarial agents.
  • HY-B0439
    Sulfadoxine

    Sulphadoxine

    Parasite Infection
    Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract and malarial infections.
  • HY-10864
    URB-597

    KDS-4103

    FAAH Autophagy Mitophagy Neurological Disease
    URB597 is a potent, orally bioavailable FAAH inhibitor with IC50 of 4.6 nM, with no activity on other cannabinoid-related targets.
  • HY-107364
    MTX-211

    EGFR PI3K Cancer
    MTX-211 is a dual inhibitor of EGFR and PI3K, used for the treatment of cancer and other diseases.
  • HY-I0020
    Galanthaminone

    (-)-Narwedine; Narwedin

    AChE Neurological Disease
    Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
  • HY-13823
    C646

    Histone Acetyltransferase Autophagy Apoptosis Epigenetic Reader Domain Cancer
    C646 is a selective and competitive histone acetyltransferase p300 inhibitor with Ki of 400 nM, and is less potent for other acetyltransferases.
  • HY-N0016
    Glycitein

    Glycetein

    Apoptosis Cancer
    Glycitein is a soybean (yellow cultivar) isoflavonoid; used in combination with other isoflavonoids such as genistein and daidzein to study apoptosis and anti-oxidation processes.
  • HY-101596
    Ethyl dirazepate

    GABA Receptor Neurological Disease
    Ethyl dirazepate is a drug which is a benzodiazepine derivative. It has anxiolytic and hypnotic and possibly other characteristic benzodiazepine properties.
  • HY-16699
    Nexturastat A

    HDAC Cancer
    Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM; no inhibition on other HDAC forms.
  • HY-B0702
    Nicergoline

    Adrenergic Receptor Neurological Disease Endocrinology
    Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins.
  • HY-B2115
    Sulfogaiacol

    Bacterial Inflammation/Immunology
    Sulfogaiacol is a antitussive agent. Sulfogaiacol is used for acute respiratory tract infections, cough and other conditions.
  • HY-102003
    Rucaparib Camsylate

    PARP Cancer
    Rucaparib Camsylate is an inhibitor of PARP with a Ki of 1.4 nM for PARP1, and also shows binding affinity to eight other PARP domains.
  • HY-18986
    SAR405838

    MI-77301

    MDM-2/p53 E1/E2/E3 Enzyme Cancer
    SAR405838 is a highly potent and selective MDM2 inhibitor, binds to MDM2 with Ki= 0.88 nM and has high specificity over other proteins.
  • HY-B0914A
    10-Undecenoic acid zinc salt

    Zinc undecylenate

    Fungal Infection
    10-Undecenoic acid zinc salt is a natural or synthetic fungistatic fatty acid, is used topically in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions.
  • HY-100297
    MK-447

    Prostaglandin Receptor Inflammation/Immunology Endocrinology
    MK-447 is a free radical scavenger, also a nonsteroidal antiinflammatory agent, and enhances the formation of the endoperoxide, PGH2, and other prostaglandins.
  • HY-B0164A
    Mizolastine dihydrochloride

    Histamine Receptor Inflammation/Immunology Endocrinology
    Mizolastine dihydrochloride is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.
  • HY-B0672
    Estradiol valerianate

    β-Estradiol 17-valerate

    Estrogen Receptor/ERR Endocrinology Cancer
    Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy drugs.
  • HY-A0069
    Doxylamine succinate

    Histamine Receptor Inflammation/Immunology Endocrinology
    Doxylamine (succinate) is a first generation antihistamine; can be used by itself as a short-term sedative and in combination with other drugs to provide night-time allergy and cold relief.
  • HY-15370
    SB-269970

    5-HT Receptor Neurological Disease
    SB269970 is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors.
  • HY-10889
    Preladenant

    SCH-420814

    Adenosine Receptor Neurological Disease
    Preladenant is a potent and competitive antagonist of the human adenosine A2A receptor with a Ki of 1.1 nM and has over 1000-fold selectivity over other adenosine receptors.
  • HY-B0164
    Mizolastine

    Histamine Receptor Inflammation/Immunology Endocrinology
    Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.
  • HY-B0978
    Diethyltoluamide

    DEET; N,N-Diethyl-m-toluamide

    Parasite Infection
    Diethyltoluamide is the most common active ingredient in insect repellents. It is intended to provide protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects.
  • HY-10617A
    Rucaparib

    AG014699; PF-01367338

    PARP Cancer
    Rucaparib (AG014699) is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, and also shows binding affinity to eight other PARP domains.
  • HY-B1052
    Lofexidine hydrochloride

    Baq-168; MDL-14042

    Adrenergic Receptor Neurological Disease Endocrinology
    Lofexidine (hydrochloride) is a selective α2-receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal.
  • HY-15224
    PCI-34051

    Apoptosis HDAC Cancer
    PCI-34051 is a potent and selective HDAC8 inhibitor with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms.
  • HY-14339
    Intepirdine

    SB-742457; GSK-742457; RVT-101

    5-HT Receptor Neurological Disease
    Intepirdine (SB742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63; exhibits >100-fold selectivity over other receptors.
  • HY-105634A
    Nomegestrol acetate

    Progesterone Receptor Endocrinology
    Nomegestrol acetate is a potent, highly selective progestogen, which is characterized as a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors, including the androgen and glucocorticoid receptors.
  • HY-B1052A
    Lofexidine

    Adrenergic Receptor Neurological Disease Endocrinology
    Lofexidine is a selective α2-receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal.
  • HY-N0216
    Benzoic acid

    Bacterial Fungal Infection
    Benzoic acid is an aromatic alcohol existing naturally in many plants and is a common additive to food, drinks, cosmetics and other products. It acts as preservatives through inhibiting both bacteria and fungi.
  • HY-14781
    Levomefolic acid

    5-MTHF

    Endogenous Metabolite Reactive Oxygen Species Cancer
    Levomefolic acid (5-MTHF) is the natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions.
  • HY-13508
    JNJ-7777120

    Histamine Receptor Inflammation/Immunology Endocrinology
    JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors.
  • HY-N0303
    Idebenone

    Ferroptosis Neurological Disease
    Idebenone is a synthetic variant of coenzyme Q10 (CoQ10), which initially developed for the treatment of Alzheimer's disease and other cognitive defects.
  • HY-19747
    HPOB

    Apoptosis HDAC Cancer
    HPOB is a highly potent and selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 56 nM, >30 fold less potent against other HDACs.
  • HY-18768
    NCT-501

    Aldehyde Dehydrogenase (ALDH) Cancer
    NCT-501 is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC50 of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC50 >57 μM).
  • HY-133129
    MS1943

    Histone Methyltransferase Cancer
    MS1943 is a first-in-class, orally bioavailable EZH2 selective degrader, with an IC50 of 120 nM. MS1943 significantly reduces EZH2 protein levels in numerous triple-negative breast cancer (TNBC) and other cancer and noncancerous cell lines. MS1943 effectively blocks proliferation of multiple TNBC and other cancer cell lines.
  • HY-10505
    Orteronel

    TAK-700

    Others Cancer
    Orteronel is a highly selective inhibitor of human 17,20-lyase with IC50 of 38 nM, and exhibits >1000-fold selectivity over other CYPs such as 11-hydroxylase and CYP3A4.
  • HY-15555
    EPZ005687

    Histone Methyltransferase Cancer
    EPZ005687 is a potent and selective inhibitor of EZH2 with Ki of 24 nM, and has 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases.
  • HY-109000
    Afabicin

    Debio 1450; AFN-1720

    Bacterial Infection
    Afabicin (Debio 1450) is the prodrug of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci.
  • HY-A0042
    Rufinamide

    CGP 33101; E 2080; RUF 331

    Others Neurological Disease
    Rufinamide(E 2080; CGP 33101; RUF 331) is a new antiepileptic agent that differs structurally from other antiepileptic drugs and is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS).
  • HY-50683
    JNJ-38877605

    c-Met/HGFR Cancer
    JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases.
  • HY-10964
    Vadimezan

    DMXAA; ASA-404

    STING Interleukin Related Cancer
    Vadimezan (DMXAA; ASA-404), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines.
  • HY-11003
    GW843682X

    GW843682

    Polo-like Kinase (PLK) Cancer
    GW843682X is a selective, ATP-competitive inhibitor of PLK1 and PLK3, with IC50s of 2.2 nM and 9.1 nM, respectively, and is also >100-fold selective against ∼30 other kinases.
  • HY-135232
    MMP-9-IN-1

    MMP Cancer
    MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor, which selectively target the hemopexin (PEX) domain of MMP-9, but not other MMPs.
  • HY-109068
    Parsaclisib

    INCB050465

    PI3K Cancer
    Parsaclisib is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.
  • HY-A0167
    Gadopentetate dimeglumine

    SH-L-451A; Gadopentetic acid dimeglumine salt

    Others Cancer
    Gadopentetate dimeglumine (SH-L-451A) is used in combination with magnetic resonance imaging (MRI) to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on the MRI.
  • HY-10966
    SB-590885

    Raf Cancer
    SB-590885 is a potent B-Raf inhibitor with Ki of 0.16 nM, and has 11-fold greater selectivity for B-Raf over c-Raf, without inhibition to other human kinases.
  • HY-N0153
    Naringin

    Naringoside

    Cytochrome P450 Autophagy Mitophagy Inflammation/Immunology Cancer
    Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities.
  • HY-10617
    Rucaparib phosphate

    AG-014699 phosphate; PF-01367338 phosphate

    PARP Cancer
    Rucaparib phosphate (AG-014699 phosphate) is a potent and oral PARP inhibitor, with a Ki of 1.4 nM for PARP1 in cell-free assay, also showing binding affinity to eight other PARP domains.
  • HY-U00189
    Sch412348

    Adenosine Receptor Neurological Disease
    Sch412348 is a potent competitive antagonist of the human adenosine A2A receptor (Ki=0.6 nM) and has >1000-fold selectivity over all other adenosine receptors.
  • HY-16734A
    Amiselimod hydrochloride

    MT-1303 hydrochloride

    LPL Receptor Cancer
    Amiselimod hydrochloride is a novel sphingosine 1-phosphate receptor-1 (S1P1) modulator, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators.
  • HY-107193
    Bacitracin

    Bacterial Infection
    Bacitracin is a polypeptide antibiotic used for staphylococcal infections. Bacitracin functions as an inhibitor of cell wall biosynthesis through its binding to the undecaprenyl pyrophosphate. The combination of bacitracin with other antibiotics has been efficient to be used as a topical agent.
  • HY-12335A
    UNC0379 TFA

    Histone Methyltransferase Cancer
    UNC0379 TFA is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 (KMT5A) with an IC50 of 7.3 μM; selective over 15 other methyltransferases.
  • HY-15802
    WZ4003

    AMPK Cancer
    WZ4003 is the first potent and highly specific NUAK kinase inhibitor with IC50 of 20 nM/100 nM for NUAK1 (ARK5)/NUAK2, without significant inhibition on other 139 kinases.
  • HY-14617
    Paradol

    [6]-Gingerone; [6]-Paradol

    COX Cancer
    Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site.
  • HY-14567
    Ciproxifan

    FUB-359

    Histamine Receptor Neurological Disease Endocrinology
    Ciproxifan(FUB-359) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.
  • HY-19369
    L-685458

    L-685,458

    Apoptosis γ-secretase Neurological Disease Cancer
    L-685458 is a potent inhibitor of Amyloid β-Protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested.
  • HY-12293
    LY2857785

    Apoptosis CDK Cancer
    LY2857785 is a type I reversible and competitive ATP kinase inhibitor against CDK9 (IC50 11 nM) and other transcription kinases CDK8 (IC50 16 nM), and CDK7 (IC50 246 nM).
  • HY-10234
    Saracatinib

    AZD0530

    Src Autophagy Cancer
    Saracatinib (AZD0530) is a potent Src family inhibitor with IC50s of 2.7 to 11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr, and Blk and shows high selectivity over other tyrosine kinases.
  • HY-119443
    Neridronate

    Others Cancer
    Neridronate is an aminobisphosphonate, licensed in Italy for the treatment of osteogenesis imperfecta (OI) and Paget’s disease of bone (PDB). Neridronate is effective also in other skeletal diseases such as osteoporosis, algodystrophy, hypercalcemia of malignancy, and bone metastases.
  • HY-15370A
    SB-269970 hydrochloride

    SB-269970A

    5-HT Receptor Neurological Disease
    SB269970 hydrochloride (SB-269970A) is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with the pKi of 8.3, exhibits >50-fold selectivity against other receptors.
  • HY-12501
    ITI214 free base

    Phosphodiesterase (PDE) Neurological Disease
    ITI-214 (free base) is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM).
  • HY-14777
    Radiprodil

    RGH-896

    iGluR Neurological Disease
    Radiprodil (RGH-896) is an orally active and selective NMDA NR2B antagonist. A potential therapeutic agent in treatment of neuropathic pain and possibly other chronic pain conditions.
  • HY-50289
    Sorbinil

    Aldose Reductase Metabolic Disease
    Sorbinil, is an Aldose reductase inhibitor (ARI). Sorbinil plays therapeutic role in treating diabetes and diabetic complications, decreases AR activity and inhibits polyol pathway, it to be found comparatively safer than other ARIs for human use.
  • HY-12335
    UNC0379

    Histone Methyltransferase Cancer
    UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 (KMT5A) with an IC50 of 7.3 μM; selective over 15 other methyltransferases.
  • HY-133122
    UCB-9260

    TNF Receptor Inflammation/Immunology
    UCB-9260, an orally active compound, inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar Kd of 13 nM.
  • HY-15441
    PF-04447943

    Phosphodiesterase (PDE) Neurological Disease
    PF-04447943 is a potent inhibitor of human recombinant PDE9A (IC50=12 nM) with >78-fold selectivity, respectively, over other PDE family members (IC50>1000 nM).
  • HY-15445
    CTEP

    RO 4956371; mGluR5 inhibitor

    mGluR Neurological Disease
    CTEP (RO 4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, and shows > 1000-fold selectivity over other mGlu receptors.
  • HY-B1289
    Cetylpyridinium chloride monohydrate

    Hexadecylpyridinium chloride monohydrate

    Bacterial Infection
    Cetylpyridinium chloride monohydrate is a cationic quaternary ammonium compound, used in some types of mouthwashes, toothpastes, throat and nasal sprays, is an antiseptic that kills bacteria and other microorganisms, effective in preventing dental plaque and reducing gingivitis.
  • HY-B1046
    Clofazimine

    Bacterial Inflammation/Immunology
    Clofazimine is a fat-soluble iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial drugs to treat AIDS and Crohn's disease.
  • HY-N0141
    Parthenolide

    (-)-Parthenolide

    NF-κB Autophagy Apoptosis Mitophagy Cancer
    Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.
  • HY-14127
    R121919

    NBI30775

    CRFR Neurological Disease Endocrinology
    R121919 is a potent small-molecule CRF1 receptor antagonist with a Ki of 2 to 5 nM for the CRF1 receptor and over 1000-fold weaker activity at the CRF2 receptor, CRF-binding protein, or 70 other receptor types.
  • HY-10863
    Anandamide

    (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide

    Cannabinoid Receptor GPR55 Endogenous Metabolite Inflammation/Immunology
    Anandamide is an immune modulator in the central nervous system acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55).
  • HY-12472
    Balipodect

    TAK-063

    Phosphodiesterase (PDE) Neurological Disease
    Balipodect (TAK-063) is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs.
  • HY-119935
    JAK3 covalent inhibitor-1

    JAK Inflammation/Immunology
    JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs.
  • HY-101945
    A-69412

    Lipoxygenase Inflammation/Immunology
    A-69412 is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase (5-LO). A-69412 has the potential to treat asthma and ulcerative colitis, and possibly other inflammatory and allergic conditions.
  • HY-N0370
    Bergapten

    5-Methoxypsoralen

    Cytochrome P450 Autophagy Cancer
    Bergapten is a natural anti-inflammatory and anti-tumor agent isolated from bergamot essential oil, other citrus essential oils and grapefruit juice. Bergapten is inhibitory towards mouse and human CYP isoforms.
  • HY-15289
    Ciproxifan maleate

    FUB 359 maleate

    Histamine Receptor Neurological Disease Endocrinology
    Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.
  • HY-12501A
    ITI214

    Phosphodiesterase (PDE) Neurological Disease
    ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM).
  • HY-100220
    GSK6853

    Epigenetic Reader Domain Cancer
    GSK6853 is a potent and selective inhibitor of the BRPF1 bromodomain. shows excellent BRPF1 potency (pKd 9.5) and greater than 1600-fold selectivity over all other bromodomains tested.
  • HY-126509
    Mal-amido-PEG10-C2-​NHS ester

    ADC Linker Cancer
    Mal-amido-PEG10-C2-NHS ester is a nonclaevable ADC linker containing a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
  • HY-126508
    Mal-amido-PEG5-C2-​NHS ester

    ADC Linker Cancer
    Mal-amido-PEG10-C2-NHS ester is a nonclaevable ADC linker containing a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules
  • HY-N6697
    Aflatoxin G1

    Others Cancer
    Aflatoxin G1 is one type of aflatoxins occuring in nature. It is produced by molds, such as Aspergillus flavus and Aspergillus parasiticus. Aflatoxins are hepatogenic, teratogenic, imunosuppressive, and carcinogenic fungal metabolites found in feeds, nuts, wine-grapes, spices, and other grain crops.
  • HY-119163
    L-902688

    Prostaglandin Receptor Inflammation/Immunology Cardiovascular Disease
    L-902688 is a potent, selective and orally active EP4 receptor agonist with a Ki of 0.38 nM and an EC50 of 0.6 nM. L-902688 shows >4,000-fold selective for EP4 over other EP and prostanoid receptors.
  • HY-12305
    Q-VD-OPh

    QVD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone

    Caspase Cancer
    Q-VD-OPh is an irreversible pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 7 with an IC50 of 48 nM and 25-400 nM for other caspases including caspase 1, 3, 8, 9, 10, and 12. Q-VD-OPh is able to cross the blood-brain barrier.
  • HY-100832
    UNC3866

    Histone Methyltransferase Cancer
    UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen (IC50=66±1.2 nM) and is more than 100-fold selective for CBX7 over the other nine members of this methyl-lysine (Kme) reader panel.
  • HY-N7000
    Perillyl alcohol

    Apoptosis Cancer
    Perillyl alcohol is a monoterpene isolated from the essential oils of lavendin, peppermint, spearmint, cherries, celery seeds, and several other plants. Perillyl alcohol is active in inducing apoptosis in tumor cells without affecting normal cells.
  • HY-15779
    K145

    SPHK Apoptosis Cancer
    K145 is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 µM and a Ki of 6.4 µM. K145 is inactive against SphK1 and other protein kinases. K145 induces cell apoptosis and has potently antitumor activity.
  • HY-P7060
    NT 13

    TPPT

    iGluR Neurological Disease
    NT 13 (TPPT) is a tetrapeptide having the amino acid sequence L-threonyl-L-prolyl-L-prolyl-L-threonine amide. NT 13 is a partial N-methyl-D-aspartate receptor (NMDAR) agonist used in the study of depression, anxiety, and other related diseases.
  • HY-N0722
    Neochlorogenic acid

    trans-5-O-Caffeoylquinic acid

    NF-κB Interleukin Related TNF Receptor COX Inflammation/Immunology Cancer
    Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.
  • HY-N2345
    Procyanidin B3

    Histone Acetyltransferase Cancer
    Procyanidin B3 is a natural product, acts as a specific HAT inhibitor, binds to the other site of p300 instead of the active site, selectively inhibits p300-mediated androgen receptor acetylation. Procyanidin B3 has no effect on HDAC or HMT (histone methyltransferase).
  • HY-15779A
    K145 hydrochloride

    SPHK Apoptosis Cancer
    K145 hydrochloride is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 µM and a Ki of 6.4 µM. K145 hydrochloride is inactive against SphK1 and other protein kinases. K145 hydrochloride induces cell apoptosis and has potently antitumor activity.
  • HY-P1687
    Siomycin A

    Bacterial Apoptosis Cancer
    Siomycin A is a thiopeptide antibiotic and is a Forkhead box M1(FOXM1) selective inhibitor without affecting other members of the Forkhead box family. Siomycin A has anti-tumor and promotes apoptosis.
  • HY-124029
    MMP13-IN-3

    MMP Inflammation/Immunology
    MMP13-IN-3 is a potent, selective, and orally active MMP-13 inhibitor (IC50=1 nM) for the potential treatment of osteoarthritis. MMP13-IN-3 is >1000 selective over other MMPs.
  • HY-126145
    S1PR1 modulator 1

    LPL Receptor Inflammation/Immunology
    S1PR1 modulator 1 is a selective S1PR1 inhibitor, with a pIC50 of 7.6, with >40- and >80-fold selectivity, over the other S1PR isoforms S1PR2/3/4.
  • HY-14151
    Prucalopride

    5-HT Receptor Neurological Disease
    Prucalopride (R093877) is a drug acting as a selective, high affinity 5-HT4 receptor agonist(pKi=8.6/8.1 for 5-HT4a/4b); >150-fold higher affinity for 5-HT4 receptors than for other receptors.
  • HY-N6810
    Thymol

    Others Infection Inflammation/Immunology
    Thymol is the main monoterpene phenol occurring in essential oils isolated from plants belonging to the Lamiaceae family, and other plants such as those belonging to the Verbenaceae, Scrophulariaceae, Ranunculaceae and Apiaceae families. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects.
  • HY-100518
    T-26c

    MMP Inflammation/Immunology
    T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes.
  • HY-13026
    Idelalisib

    CAL-101; GS-1101

    PI3K Autophagy Cancer
    Idelalisib (CAL-101; GS-1101) is a highly selective and orally bioavailable p110δ inhibitor with an IC50 of 2.5 nM, showing 40- to 300-fold selectivity for p110δ over other PI3K class I enzymes.
  • HY-111791
    ACY-1083

    HDAC Cancer
    ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy.
  • HY-W040289
    Mal-amido-PEG2-NHS ester

    ADC Linker Cancer
    Mal-amido-PEG2-NHS ester is a nonclaevable ADC linker containing a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
  • HY-111226
    GSK5182

    Estrogen Receptor/ERR Reactive Oxygen Species Cancer Cardiovascular Disease
    GSK5182 is a highly selective inverse agonist of estrogen-related receptor γ (ERRγ) with an IC50 of 79 nM and does not interact with other nuclear receptors, including ERRα or ERα. GSK5182 also induces Reactive Oxyen Species (ROS) generation in hepatocellular carcinoma (HCC).
  • HY-13271
    Tubastatin A Hydrochloride

    Tubastatin A HCl; TSA HCl

    HDAC Autophagy Apoptosis Cancer
    Tubastatin A (Hydrochloride) is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more).
  • HY-115475
    SW-100

    HDAC Neurological Disease
    SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier.
  • HY-16986
    EPZ011989

    Histone Methyltransferase Cancer
    EPZ011989 is a potent, selective orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 wt and EZH2 Y646; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase.
  • HY-15897
    LDN-212854

    TGF-β Receptor Cancer
    LDN-212854 is a novel BMP inhibitor that exhibits substantially greater selectivity for BMP versus the TGF-β type I receptors; possesses a bias towards ALK2(IC50=1.3 nM) versus ALK1 and ALK3 compared to other inhibitors.
  • HY-13271A
    Tubastatin A

    HDAC Apoptosis Autophagy Cancer
    Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more).
  • HY-N6748
    Roquefortine C

    P-glycoprotein Cytochrome P450 Bacterial Cancer Infection
    Roquefortine C, a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins. Roquefortine C has bacteriostatic activities against Gram-positive bacteria.
  • HY-N0160
    Kinetin

    6-Furfuryladenine; N6-Furfuryladenine

    Others Neurological Disease
    Kinetin (N6-furfuryladenine) belongs to the family of N6-substituted adenine derivatives known as cytokinins, which are plant hormones involved in cell division, differentiation and other physiological processes. Kinetin has anti-aging effects.
  • HY-10394
    Linezolid

    PNU-100766

    Bacterial Infection
    Linezolid (PNU-100766) is the first member of the class of oxazolidinone synthetic antibiotic. Linezolid acts by inhibiting the initiation of bacterial protein synthesis. Linezolid is used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics.
  • HY-G0025
    Tetrabenazine Metabolite

    (-)-β-Dihydrotetrabenazine; (-)-β-HTBZ

    Monoamine Transporter Drug Metabolite Neurological Disease
    Tetrabenazine Metabolite is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a high affinity (Ki=13.4 nM). Tetrabenazine Metabolite is be developed for the treatment of chorea associated with Huntington’s disease and other hyperkinetic disorders.
  • HY-69220
    7-Octynoic acid

    PROTAC Linker Cancer
    7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
  • HY-U00280
    Potassium Channel Activator 1

    Others Neurological Disease
    Potassium Channel Activator 1 is an agent for treating, one or more disorders or conditions wherein the dopaminergic system is disrupted, such as one or more disorders or conditions independently selected from the group consisting of: schizophrenia and other psychotic states; mood disorders ADHD; aggression; movement disorders.
  • HY-18664
    PFI-4

    Epigenetic Reader Domain Cancer
    PFI-4 is a potent and selective and cell permeable BRPF1 bromodomain inhibitor (IC50 = 80 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4.
  • HY-50098
    Mardepodect

    PF-2545920

    Phosphodiesterase (PDE) Neurological Disease
    Mardepodect (PF-2545920) is a potent, orally active and selective PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs. Mardepodect can cross the blood-brain barrier.
  • HY-N2450
    Sulforaphene

    Apoptosis EGFR ERK NF-κB Cancer
    Sulforaphene, isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EGFR, p-ERK1/2, NF‐κB and other signals.
  • HY-14435
    Pyridone 6

    JAK Cancer
    Pyridone 6 is a pan-JAK inhibitor, which potently inhibits the JAK kinase family, with IC50s of 1 nM for JAK2 and TYK2, 5 nM for JAK3, and 15 nM for JAK1, while displaying significantly weaker affinities (130 nM to >10 mM) for other protein tyrosine kinases.
  • HY-128849
    Eprodisate

    Others Inflammation/Immunology
    Eprodisate is a new compound designed to interfere with interactions between amyloidogenic proteins and glycosaminoglycans and thereby inhibit polymerization of amyloid fibrils and deposition of the fibrils in tissues. Eprodisate slow the progression of AA amyloidosis-related renal disease and has possible applicability to other types of amyloidosis.
  • HY-P1221
    ProTx II

    Sodium Channel Neurological Disease
    ProTx II is a selective blocker of Nav1.7 sodium channels with an IC50 of 0.3 nM, and is at least 100-fold selective for Nav1.7 over other sodium channel subtypes. ProTx-II inhibits sodium channels by decreasing channel conductance and shifting activation to more positive potentials and blocks action potential propagation in nociceptors.
  • HY-107477
    GSK8573

    Epigenetic Reader Domain Cancer
    GSK8573 (compound 23) is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 with a Kd value of 1.04 μM and is inactive against BAZ2A/B and other bromodomain familiy.
  • HY-126973
    BI-1230

    HCV Protease Infection
    BI-1230 is potent and digit nanomolar inhibitor of HCV NS3 protease and of viral replication. BI-1230 is also highly selective against other serine/cysteine proteases. BI-1230 shows good Pharmacokinetic(PK) activity.
  • HY-50098A
    Mardepodect hydrochloride

    PF-2545920 hydrochloride

    Phosphodiesterase (PDE) Cancer
    Mardepodect hydrochloride (PF-2545920 hydrochloride) is a potent, orally active and selective PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs. Mardepodect hydrochloride can cross the blood-brain barrier.
  • HY-108497
    L-803087

    Somatostatin Receptor Cancer Neurological Disease
    L-803087 is a potent and selective somatostatin sst4 receptor agonist with a Ki of 0.7 nM, which is > 280-fold higher than other somatostatin receptors. L-803087 facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice.
  • HY-B1139
    Tolperisone hydrochloride

    Others Neurological Disease
    Tolperisone hydrochloride is a centrally acting muscle relaxant, is indicated for use in the treatment of pathologically increased tone of the cross-striated muscle caused by neurological diseases (damage of the pyramidal tract, multiple sclerosis, myelopathy, encephalomyelitis) and of spastic paralysis and other encephalopathies manifested with muscular dystonia.
  • HY-108512
    PD 144418

    Sigma Receptor Neurological Disease
    PD 144418 is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki values of 0.08 nM and 1377 nM for σ1 and σ2 respectively), devoid of any significant affinity for other receptors, ion channels and enzymes. PD 144418 shows potential antipsychotic activity.
  • HY-B2004
    Thifluzamide

    Fungal Infection
    Thifluzamide is a powerful and effective fungicide. When used safely and correctly it can be effective on rice and other crops because of improved water dispersal techniques. Thifluzamide is highly active against Basidiomycete fungi, in particular Rhizoctonia solani, primarily in rice, potatoes, and turf markets.
  • HY-16986A
    EPZ011989 trifluoroacetate

    EPZ-011989 trifluoroacetate

    Histone Methyltransferase Cancer
    EPZ011989 trifluoroacetate is a potent, selective orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 wt and EZH2 Y646; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase.
  • HY-114404
    SJFα

    PROTAC p38 MAPK Autophagy Cancer
    SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16  nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 µM.
  • HY-12522
    PF-06380101

    Aur0101; Auristatin-0101

    Microtubule/Tubulin ADC Cytotoxin Cancer
    PF-06380101 (Aur0101), an auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue. PF-06380101 (Aur0101) shows excellent potencies in tumor cell proliferation assays and differential ADME properties when compared to other synthetic auristatin analogues that are used in the preparation of ADCs.
  • HY-103258
    TC ASK 10

    MAP3K Apoptosis Cancer
    TC ASK 10 (Compound 10) is a potent, selective and orally active apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 of 14 nM. The inhibitory activities of TC ASK 10 towards other representative panel of kinases are less than 50%, except for ASK2 (IC50 of 0.51 μM).
  • HY-13221
    BRL 54443

    5-HT Receptor Cardiovascular Disease
    BRL 54443 is a potent 5-HT1E/1F receptor agonist (pKi values are 8.7 and 8.9 respectively); displays > 30-fold selectivity over other 5-HT and dopamine receptors.
  • HY-116761
    GSK467

    Histone Demethylase Cancer
    GSK467 is a cell penetrant and selective KDM5B (JARID1B or PLU1) inhibitor with a Ki of 10 nM, shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other Jumonji family members.
  • HY-101980
    AZD4635

    HTL1071

    Adenosine Receptor Cancer
    AZD4635 is a potent and selective, orally available adenosine A2A receptor (A2AR) antagonist. AZD4635 binds to human A2AR with a Ki of 1.7 nM and with > 30-fold selectivity over other adenosine receptors.
  • HY-103244
    CITCO

    Apoptosis Cancer
    CITCO, an imidazothiazole derivative, is a selective Constitutive androstane receptor (CAR) agonist. CITCO inhibits growth and expansion of brain tumour stem cells (BTSCs) and has an EC50 of 49 nM over pregnane X receptor (PXR), and no activity on other nuclear receptors.
  • HY-16953
    JNJ 303

    Potassium Channel Cardiovascular Disease
    JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. JNJ 303 does not have any effects on other cardiac channels at concentrations of 3.3 μM for INa, Ica, Ito, and IKr. JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP).
  • HY-N0119
    Naringin Dihydrochalcone

    Naringin DC

    NF-κB Cancer
    Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses NF-κB signaling pathway.
  • HY-133146
    DJ001

    Phosphatase Inflammation/Immunology
    DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase-σ (PTPσ) inhibitor with an IC50 of 1.43 μM. DJ001 displays no inhibitory activity against other phosphatases, with only modest inhibitory activity against Protein Phosphatase 5. DJ001 promotes promote hematopoietic stem cell regeneration.
  • HY-108328
    PF-04937319

    Glucokinase Metabolic Disease
    PF-04937319 is a glucokinase activator (GKA) with EC50 value of 154.4  μM, one of the most promising strategies for the treatment of type 2 diabetes mellitus. PF-04937319 is designed to maintain glucose-lowering efficacy while mitigating the risk of hypoglycaemia observed with many other GKAs.
  • HY-108669
    AZ10606120 dihydrochloride

    P2X Receptor Cancer Neurological Disease
    AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of ~10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth.
  • HY-12752
    Alimemazine

    Trimeprazine

    Others Inflammation/Immunology Neurological Disease
    Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays sedative, antiserotonin, antispasmodic, and antiemetic properties.
  • HY-126507
    Mal-amido-PEG1-C2-​NHS ester

    ADC Linker Cancer
    Mal-amido-PEG1-C2-NHS ester is a nonclaevable ADC linker containing a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules
  • HY-11011
    A-770041

    Src Inflammation/Immunology
    A-770041 is selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling.
  • HY-11091
    Razaxaban hydrochloride

    BMS 561389 hydrochloride; DPC 906 hydrochloride

    Factor Xa Thrombin Cardiovascular Disease
    Razaxaban hydrochloride (BMS 561389 hydrochloride) is a highly potent, selective and orally active factor Xa inhibitor with a Ki of 0.19 nM. Razaxaban hydrochloride exhibits excellent selectivity (>5000-fold) for factor Xa over other related serine proteases. Razaxaban hydrochloride is also a potent thrombin inhibitor with a Ki of 540 nM. Razaxaban hydrochloride has strongly antithrombotic activity.
  • HY-14539
    Clozapine

    HF 1854

    Dopamine Receptor mAChR Neurological Disease
    Clozapine (HF 1854) is an antipsychotic used to treat schizophrenia. Clozapine is a potent antagonist of dopamine and a number of other receptors, with a Ki of 9.5 nM for M1 receptor. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).
  • HY-109008
    Nacubactam

    OP0595 free acid

    Bacterial Infection
    Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and class C β-lactamases. Nacubactam (OP0595 free acid) acts as a penicillin binding protein (PBP) 2-active antibacterial, and gives β-lactamase-independent potentiation of β-lactams targeting other PBPs.
  • HY-105309
    GSK-626616

    DYRK Cardiovascular Disease
    GSK-626616 is a potent, orally bioavailable inhibitor of DYRK3 (IC50=0.7 nM). GSK-626616 inhibits other members of the DYRK family (e.g., DYRK1A and DYRK2) with similar potency, which is a potential therapy for the treatment of anemia.
  • HY-12755
    ML141

    CID-2950007

    Apoptosis Ras Cancer
    ML141 (CID-2950007) is a potent, allosteric,selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC50s of 2.1 and 2.6 μM, respectively. ML141 shows low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 do not show cytotoxicity in multiple cell lines.
  • HY-129774
    Phthalimide-PEG4-MPDM-OH

    PROTAC Linker Cancer
    Phthalimide-PEG4-MPDM-OH is a PROTAC linker, which refers to the PEGs composition. Phthalimide-PEG4-MPDM-OH can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
  • HY-13686
    PQ401

    Apoptosis IGF-1R Cancer
    PQ401 is a potent inhibitor of IGF-IR signaling. PQ401 inhibits IGF-I-stimulated IGF-IR autophosphorylation with an IC50 of 12.0 μM in a series of studies in MCF-7 cells. PQ401 is effective at inhibiting IGF-I-stimulated growth of MCF-7 cells (IC50, 6 μM). PQ401 is a potential agent for breast and other IGF-I-sensitive cancers. PQ401 induces caspase-mediated apoptosis.
  • HY-118342
    PQCA

    mAChR Neurological Disease
    PQCA is a highly selective and potent muscarinic M1 receptor positive allosteric modulator. PQCA has an EC50 value of 49 nM and 135 nM on rhesus and human M1 receptor, respectively, and is inactive for other muscarinic receptors. PQCA improves cognitive performance and cerebral blood flow in rat, cynomolgus macaque, and rhesus macaque. PQCA has potential to reduce the cognitive deficits associated with Alzheimer's disease.
  • HY-124652
    TBK1/IKKε-IN-4

    IKK Cancer
    TBK1/IKKε-IN-4 is a 6-aminopyrazolopyrimidine derivative and a potent, selective TBK1 and IKKε inhibitor with IC50 values of 13 nM and 59 nM, respectively. TBK1/IKKε-IN-4 shows 100- to 1000-fold less activity against other protein kinases including PDK1, PI3K family members and mTOR.
  • HY-N6727
    Gliotoxin

    Aspergillin

    Apoptosis PKA NF-κB Inflammation/Immunology
    Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells.
  • HY-129772
    Phthalimide-PEG3-C2-OTs

    PROTAC Linker Cancer
    Phthalimide-PEG3-C2-OTs (Compound 5) is a PROTAC linker, which refers to the PEGs composition. Phthalimide-PEG3-C2-OTs can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
  • HY-10182B
    CHIR-99021 trihydrochloride

    CT99021 trihydrochloride

    GSK-3 Wnt β-catenin Autophagy Cancer
    CHIR-99021 trihydrochloride (CT99021 trihydrochloride) is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 trihydrochloride enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 trihydrochloride induces autophagy.
  • HY-40178
    NH2-C4-NH-Boc

    PROTAC Linker Cancer
    NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
  • HY-111191
    ONO-2952

    Others Neurological Disease
    ONO-2952 is a potent, selective and orally active translocator protein 18 kDa (TSPO) antagonist with Ki of 0.33-9.30 nM for rat and human TSPO. ONO-2952 is more selective for TSPO than other receptors, transporters, ion channels and enzymes. ONO-2952 exerts its anti-stress effects through inhibition of excessive activation of noradrenergic system in the brain without the amnesic effect. ONO-2952 has the potential for irritable bowel syndrome treatment.
  • HY-133028
    CKI-7

    Casein Kinase CDK SGK Ribosomal S6 Kinase (RSK) Cancer
    CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases.
  • HY-100359
    CL-82198

    MMP Cancer Inflammation/Immunology
    CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs. CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression.
  • HY-13233A
    Talabostat mesylate

    Val-boroPro mesylate; PT100 mesylate

    Dipeptidyl Peptidase Cancer Inflammation/Immunology
    Talabostat mesylate (Val-boroPro mesylate; PT100 mesylate) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC50 < 4 nM; Ki = 0.18 nM) and the first clinical inhibitor of fibroblast activation protein (FAP) (IC50 = 560 nM), inhibits DPP8/9 (IC50 = 4/11 nM; Ki = 1.5/0.76 nM), quiescent cell proline dipeptidase (QPP) (IC50 = 310 nM), DPP2, and some other DASH family enzymes. Antineoplastic and hematopoiesis- stimulating activities.
  • HY-117273
    AZ304

    Raf Autophagy Cancer
    AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC50s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 (IC50, 6 nM), CSF1R (IC50, 35 nM). Anti-tumor activity.
  • HY-126257
    AKT-IN-3

    Akt Apoptosis Cancer
    AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells.
  • HY-124602
    DI-591

    E1/E2/E3 Enzyme Cancer
    DI-591 is a potent, high-affinity and cell-permeable inhibitor of the DCN1-UBC12 interaction. DI-591 binds to DCN1 and DCN2 with Ki values of 12 nM and 10.4 nM, respectively and has no appreciable binding to DCN3, DCN4, and DCN5 proteins. DI-591 selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members.
  • HY-130715
    tert-Butyl 11-aminoundecanoate

    PROTAC Linker Cancer
    tert-Butyl 11-aminoundecanoate (compound 6b) is a PROTAC linker, which refers to the PEG composition. tert-Butyl 11-aminoundecanoate can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
  • HY-109118A
    Masupirdine mesylate

    SUVN-502 mesylate

    5-HT Receptor Neurological Disease
    Masupirdine mesylate (SUVN-502 mesylate) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease.
  • HY-13516
    Aloperine

    Apoptosis HIV Filovirus Autophagy Cancer Infection Inflammation/Immunology
    Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties. Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China. Aloperine induces apoptosis and autophagy in HL-60 cells.
  • HY-112081
    BAY-707

    DNA/RNA Synthesis Cancer
    BAY-707 is a substrate-competitive, highly potent and selective inhibitor of MTH1(NUDT1) with an IC50 of 2.3 nM. BAY-707 has a good pharmacokinetic (PK) profile to other MTH1 compounds and is well-tolerated in mice, but shows a clear lack of in vitro or in vivo anticancer efficacy.
  • HY-107625A
    SNAP 94847 hydrochloride

    MCHR1 (GPR24) Neurological Disease
    SNAP 94847 hydrochloride is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (Ki= 2.2 nM, Kd=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 hydrochloride binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters.
  • HY-112179
    GSK180

    Others Inflammation/Immunology
    GSK180 is a selective, competitive, and potent inhibitor of kynurenine-3-monooxygenase (KMO), a key enzyme of tryptophan metabolism (IC50, ~6 nM), but shows negligible activity against other enzymes on the tryptophan pathway. GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition.
  • HY-15589
    GW9508

    GPR40 Potassium Channel Metabolic Disease Inflammation/Immunology Cardiovascular Disease
    GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 shows ~100-fold selectivity for GPR40 over GPR120. GW9508 is inactive against other GPCRs, kinases, proteases, integrins and PPARs. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. Anti-inflammatory and anti-atherosclerotic activities.
  • HY-19625
    MCB-613

    Others Cancer
    MCB-613 is a potent Steroid receptor coactivator SRC small molecule ‘stimulator’ (SMS), super-stimulates SRCs’ transcriptional activity. MCB-613 increases SRCs’ interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). MCB-613 is a SMS that target oncogenes can be exploited as anti-cancer agents by over-stimulating the SRC oncogenic program.
  • HY-10182
    CHIR-99021

    CT99021

    GSK-3 Wnt β-catenin Autophagy Cancer
    CHIR-99021 (CT99021) is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 induces autophagy.
  • HY-105064D
    Zoniporide hydrochloride hydrate

    CP-597396 hydrochloride hydrate

    Sodium Channel Cardiovascular Disease
    Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate inhibits human NHE-1 (IC50=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride hydrate potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC50=59 nM).
  • HY-108706
    KDM2A/7A-IN-1

    Histone Demethylase Cancer
    KDM2A/7A-IN-1 is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC50 of 0.16 μM for KDM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive on methyl transferases, and histone acetyl transferases.
  • HY-13757
    Tamoxifen Citrate

    ICI 46474; (Z)-Tamoxifen Citrate; trans-Tamoxifen Citrate

    Estrogen Receptor/ERR HSP Apoptosis Autophagy Cancer
    Tamoxifen Citrate (ICI 46474) is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate activates autophagy and induces apoptosis.
  • HY-135366
    HPN-01

    IKK Inflammation/Immunology
    HPN-01 is a potent and selective IKK inhibitor, with pIC50 values of 6.4, 7.0 and <4.8 for IKK-α, IKK-β and IKK-ε, respectively. HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, and VEGFR-2.
  • HY-107625
    SNAP 94847

    MCHR1 (GPR24) Neurological Disease Endocrinology
    SNAP 94847 is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (Ki= 2.2 nM, Kd=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters.
  • HY-10797
    CJ-42794

    CJ-042794

    Prostaglandin Receptor Inflammation/Immunology Endocrinology
    CJ-42794 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist, inhibits [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5, a binding affinity that was at least 200-fold more selective for the human EP4 receptor than other human EP receptor subtypes (EP1, EP2, and EP3).
  • HY-103463
    SA57

    FAAH MAGL Neurological Disease
    SA57 is a potent, selective FAAH inhibitor with IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH. SA57 also inhibits the 2-arachidonoylglycerol hydrolases MAGL (IC50s of 410 nM and 1.4 μM for mouse and human MAGL) and mouse α/β-hydrolase domain-containing protein 6 (mABHD6; IC50 of 850 nM), but not other brain serine hydrolases.
  • HY-13302
    CP-547632

    VEGFR FGFR Cancer
    CP-547632 is a well-tolerated, orally-bioavailable inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases with IC50s of 11 nM and 9 nM, respectively. CP-547632 is an ATP-competitive kinase inhibitor and it is selective relative to epidermal growth factor receptor, platelet-derived growth factor β, and other related TKs. CP-547632 has antitumor efficacy.
  • HY-107676
    SIB-1553A

    nAChR Neurological Disease
    SIB-1553A is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs. SIB-1553A is also a selective neuronal nAChR ligand. SIB-1553A is a cognitive enhancer, and has therapeutic potential for the symptomatic treatment of Alzheimer’s disease and other cognitive disorders.
  • HY-105685
    SRX246

    Vasopressin Receptor Neurological Disease
    SRX246 is a potent, CNS-penetrant, highly selective, orally bioavailable vasopressin 1a (V1a) receptor antagonist (Ki=0.3 nM for human V1a). SRX246 has no interaction at V1b and V2 receptors. SRX246 also displays negligible binding at 64 others receptors classes, including 35 G-proteincoupled receptors. SRX246 can be used for treatment of stress-related disorders.
  • HY-12649
    Y16

    Ras Cancer
    Y16 is a specific inhibitor of Leukemia-associated Rho guanine nucleotide exchange factor (LARG) with a Kd value of 76 nM. Y16 is active in blocking the interaction of LARG and related G-protein-coupled Rho GEFs with RhoA. Y16 shows no detectable effect on other diffuse B-cell lymphoma (Dbl) family Rho GEFs, Rho effectors, or a RhoGAP.
  • HY-W016628
    L-Gulono-1,4-lactone

    Endogenous Metabolite Metabolic Disease
    L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.
  • HY-B1290
    2-Phenylethanol

    Phenylethyl alcohol; Phenethyl alcohol; Benzyl carbinol

    Virus Protease Bacterial Infection
    2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid that is slightly soluble in water. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
  • HY-121629
    PS210

    PDK-1 Cancer
    PS210 is a potent and selective PDK1 activator with a Kd of 3 μM and targets the PIF-binding pocket of PDK1. PS210 is inactive against other protein kinases, including PDK1 downstream signaling components such as S6K, PKB/Akt or GSK3. In cells, the prodrug of PS210 (PS423) acts as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K.
  • HY-13302B
    CP-547632 hydrochloride

    VEGFR FGFR Cancer
    CP-547632 hydrochloride is a well-tolerated, orally-bioavailable inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases with IC50s of 11 nM and 9 nM, respectively. CP-547632 hydrochloride is an ATP-competitive kinase inhibitor and it is selective relative to epidermal growth factor receptor, platelet-derived growth factor β, and other related TKs. CP-547632 hydrochloride has antitumor efficacy.
  • HY-19269
    FK706

    Elastase Inflammation/Immunology
    FK706 is a potent, slow-binding and competitive inhibitor of human neutrophil elastase with an IC50 of 83 nM and a Ki of 4.2 nM. FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase with IC50s of 22 nM and 100 nM, respectively, and has no inhibitory activity against other serine proteinases such as human pancreatic trypsin, human pancreatic α-chymotrypsin and human leukocyte cathepsin G. FK706 has anti-inflammatory effect.
  • HY-112831
    BI-409306

    Phosphodiesterase (PDE) Neurological Disease
    BI-409306 is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 µM), PDE1C (IC50, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM); BI-409306 can be used in the research of memory enhancement in CNS disorders.
  • HY-19336
    BAZ2-ICR

    Epigenetic Reader Domain Cancer
    BAZ2-ICR is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM and 180 nM, and Kds of 109 nM and 170 nM, respectively. BAZ2-ICR shows 10-15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains. BAZ2-ICR is an epigenetic chemical probe.
  • HY-120214
    TAS05567

    Syk Inflammation/Immunology
    TAS05567 is a potent, highly selective, ATP-competitive and orally active Syk inhibitor with an IC50 of 0.37 nM. In a panel of 192 kinases, TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, JAK2, KDR and RET with IC50s of 10 nM, 4.8 nM, 600 nM and 29 nM, respectively). TAS05567 can be used for humoral immune-mediated inflammatory conditions such as autoimmune and allergic diseases.
  • HY-N0925
    Tetrahydroberberine

    Canadine

    Dopamine Receptor Neurological Disease
    Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber; has micromolar affinity for dopamine D(2) (pK(i) = 6.08) and 5-HT(1A) (pK(i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors (5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK(i) < 5.00).
  • HY-12076
    BMS 777607

    BMS 817378

    c-Met/HGFR TAM Receptor Cancer
    BMS 777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50s of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively, and 40-fold more selective for Met-related targets than Lck, VEGFR-2, and TrkA/B, with more than 500-fold greater selectivity versus all other receptor and non receptor kinases.
  • HY-15346
    Copanlisib

    BAY 80-6946

    PI3K Cancer
    Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity.
  • HY-12098
    Verubulin hydrochloride

    MPC-6827 hydrochloride

    Microtubule/Tubulin Cancer
    Verubulin hydrochloride (MPC-6827 hydrochloride) is a blood brain barrier permeable microtubule-disrupting agent, with potent and broad-spectrum in vitro and in vivo cytotoxic activities. Verubulin hydrochloride (MPC-6827 hydrochloride) exhibits potent anticancer activity in human MX-1 breast and other mouse xenograft cancer models. Verubulin hydrochloride (MPC 6827 hydrochloride) is a promising candidate for the treatment of multiple cancer types.
  • HY-A0095
    Flibanserin

    BIMT-17; BIMT-17BS

    5-HT Receptor Neurological Disease
    Flibanserin (BIMT-17) is a full agonist of the serotonin 5-HT1A receptor (Ki=1 nM) and an antagonist of 5-HT2A (49 nM). Flibanserin binds to dopamine D4 receptors (4-24 nM), and has negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin is efficacious in treating hypoactive sexual desire disorder (HSDD).
  • HY-N2499
    Dehydrotumulosic acid

    Others Metabolic Disease
    Dehydrotumulosic acid, one of the effective constituents of Poria cocos, was isolated from the chloroform-soluble material of ethanol extract of the fungus. Poria cocos, a popular Chinese medicinal herb of fungal origin, has been included in many combinations with other CM herbs for its traditionally claimed activities of inducing diuresis, excreting dampness, invigorating the spleen and tranquilizing the mind and its modern pharmacological use of modulating the immune system of the body.
  • HY-130605
    BAY-1797

    P2X Receptor Neurological Disease
    BAY-1797 is a potent, orally active, and selective P2X4 antagonist, with an IC50 of 211 nM against human P2X4. BAY-1797 displays no or very weak activity on the other P2X ion channels. BAY-1797 shows anti-nociceptive and anti-inflammatory effects.
  • HY-16576A
    (Z)-SMI-4a

    Pim Cancer
    (Z)-SMI-4a is a poten, selective, cell-permeable and ATP-competitive Pim-1 inhibitor with an IC50 of 24 μM and a Ki of 0.6 µM. (Z)-SMI-4a also inhibits Pim-2 (IC50 of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. (Z)-SMI-4a has anticancer activity.
  • HY-129056
    Melagatran

    Thrombin Cardiovascular Disease
    Melagatran is a direct and orally active inhibitor of thrombin, without interacting with any other enzymes in the coagulation cascade or fibrinolytic enzymes aside from thrombin. Melagatran does not require endogenous co-factors for its antithrombin effect and may help to alleviate some of the damaging effects of endotoxemia. Melagatran has the potential to provide a rational approach in the prevention of arterial occlusion.
  • HY-N4192
    Toringin

    Others Cancer Cardiovascular Disease
    Toringin, a bioflavonoid, is isolated from the bark of Docyniopsis tschonoski. Toringin progressively decreases not only the cis-effect of the expanded CTG repeats but cytotoxicity as well. Exposure to isosakuranetin, Toringin rescues PC12 neuronal cells. Flavonoids are efficacious for ameliorating the RNA gain of function caused by expanded CTG repeats, and have various biological activities and beneficial actions against cancers, coronary heart disease, among other pathologies.
  • HY-129364
    5-A-RU hydrochloride

    5-Amino-6-(D-ribitylamino)uracil hydrochloride

    Others Inflammation/Immunology
    5-A-RU hydrochloride (5-Amino-6-(D-ribitylamino)uracil hydrochloride), a precursor of bacterial Riboflavin, is a mucosal-associated invariant T (MAIT) cells activator. 5-A-RU hydrochloride forms potent MAIT-activating antigens via non-enzymatic reactions with small molecules, such as glyoxal and methylglyoxal, which are derived from other metabolic pathways.
  • HY-10472
    LY2811376

    Beta-secretase Neurological Disease
    LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.
  • HY-12975
    AZ6102

    PARP Cancer
    AZ6102 is a potent dual TNKS1 and TNKS2 inhibitor, with IC50s of 3 nM and 1 nM, respectively, and alao has 100-fold selectivity against other PARP family enzymes, with IC50s of 2.0 μM, 0.5 μM, and >3 μM, for PARP1, PARP2, and PARP6, respectively.
  • HY-15346A
    Copanlisib dihydrochloride

    BAY 80-6946 dihydrochloride

    PI3K Cancer
    Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib dihydrochloride has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib dihydrochloride has superior antitumor activity.
  • HY-18628
    UMI-77

    Bcl-2 Family Cancer
    UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.
  • HY-119940
    MC180295

    (rel)-MC180295

    CDK Cancer
    MC180295 ((rel)-MC180295) is a potent and selective CDK9-Cyclin T1 inhibitor, with an IC50 of 5 nM, at least 22-fold more selective for CDK9 over other CDKs. MC180295 also inhibits GSK-3α and GSK-3β. MC180295 ((rel)-MC180295) has potent anti-tumor effect.
  • HY-106005
    MMV390048

    Parasite PI4K Infection
    MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kd app=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent.
  • HY-104066
    Theliatinib

    HMPL-309

    EGFR Cancer
    Theliatinib (HMPL-309) is a potent, ATP-competitive, orally active and highly selective EGFR inhibitor with a Ki of 0.05 nM and an IC50 of 3 nM. Theliatinib has an IC50 of 22 nM for EGFR T790M/L858R mutant. Theliatinib shows >50-fold selectivity for EGFR than other kinases. Anti-tumor activity.
  • HY-106019C
    Liarozole dihydrochloride

    R75251 dihydrochloride

    Cytochrome P450 Cancer Inflammation/Immunology
    Liarozole dihydrochloride (R75251; R85246) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase). Liarozole dihydrochloride prevents the catabolism of retinoic acid via inhibition of 4-hydroxylase and exhibits retinoid sparing and retinoid-mimetic effects in vivo. Liarozole dihydrochloride is an imidazole derivative; it is being investigated as a non-hormonal agent in prostate cancer and in the treatment of various other cancers and skin disorders.
  • HY-111501
    H4R antagonist 1

    Histamine Receptor Inflammation/Immunology Endocrinology
    H4R antagonist 1 is a potent and highly selective histamine H4 receptor (H4R) antagonist with an IC50 of 27 nM. H4R antagonist 1 does not show any noticeable binding affinity to other subtypes of histamine receptors, H1R, H2R, and H3R.
  • HY-10405
    Pamapimod

    Ro4402257; R1503

    p38 MAPK Autophagy Inflammation/Immunology
    Pamapimod (Ro4402257) is a potent, selective and orally active p38 MAPK inhibitor with IC50s of 14 nM and 480 nM and Kis of 1.3 nM and 120 nM for p38α and p38β, respectively. Pamapimod has no activity against p38δ or p38γ isoforms. Pamapimod has the potential for rheumatoid arthritis and other autoimmune diseases treatment.
  • HY-114263
    NXT629

    PPAR Cancer
    NXT629 is a potent, selective, and competitive PPAR-α antagonist, with an IC50 of 77 nM for human PPARα, shows high selectivity over other nuclear hormone receptor, such as PPARδ, PPARγ, ERβ, GR and TRβ, IC50s are 6.0, 15, 15.2, 32.5 and >100 μM, respectively. NXT629 has potent anti-tumor activity and inhibits experimental metastasis of cancer cell in animal models.
  • HY-135841
    CM10

    Aldehyde Dehydrogenase (ALDH) Cancer Metabolic Disease
    CM10 is a potent and selective aldehyde dehydrogenase 1A family inhibitor (ALDH1Ai), with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 does not inhibit any of the other ALDH family members. CM10 can regulate metabolism and has anti-cancer activity.
  • HY-107419
    NU6140

    CDK Aurora Kinase Cancer
    NU6140 is a selective CDK2-cyclin A inhibitor (IC50, 0.41 μM), exhibits 10- to 36-fold selectivity over other CDKs. NU6140 also potently inhibits Aurora A and Aurora B, with IC50s of 67 and 35 nM, respectively. Enhances the apoptotic effect, with anti-cancer activity.
  • HY-102070
    NS13001

    Potassium Channel Neurological Disease
    NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias.
  • HY-13233
    Talabostat

    Val-boroPro; PT100

    Dipeptidyl Peptidase Cancer Inflammation/Immunology
    Talabostat (Val-boroPro; PT100) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC50 < 4 nM; Ki = 0.18 nM) and the first clinical inhibitor of fibroblast activation protein (FAP) (IC50 = 560 nM), inhibits DPP8/9 (IC50 = 4/11 nM; Ki = 1.5/0.76 nM), quiescent cell proline dipeptidase (QPP) (IC50 = 310 nM), DPP2, and some other DASH family enzymes. Antineoplastic and hematopoiesis- stimulating activities.
  • HY-N1457
    Chrysosplenetin

    Ferroptosis P-glycoprotein Cytochrome P450 Metabolic Disease
    Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A.
  • HY-130641
    Br-C10-methyl ester

    PROTAC Linker Cancer
    Br-C10-methyl ester is a PROTAC linker, which refers to the alkyl/ether composition. Br-C10-methyl ester is used in the synthesis of a series of PROTACs (MS432).  PROTACs contain two different ligands connected by a linker; one is the VHL ligand portion and the other is for the target protein.
  • HY-18979
    Lactimidomycin

    Influenza Virus Cancer Infection
    Lactimidomycin is a glutarimide-containing compound isolated from Streptomyces. Lactimidomycin is a potent inhibitor of eukaryotic translation elongation. Lactimidomycin has a potent antiproliferative effect on tumor cell lines and selectively inhibit protein translation. Lactimidomycin inhibits protein synthesis with an IC50 value of 37.82 nM. Lactimidomycin is also a potent and non-toxic inhibitor of dengue virus 2 and other RNA viruses. Anticancer and antiviral activities.
  • HY-15785
    TAS-116

    HSP Cancer
    TAS-116 is an oral bioavailable, ATP-competitive, highly specific HSP90α/HSP90β inhibitor (Kis of 34.7 nM and 21.3 nM, respectively) without inhibiting other HSP90 family proteins such as GRP94. TAS-116 demonstrates less ocular toxicity.
  • HY-B0498
    Bindarit

    AF2838

    CCR Inflammation/Immunology Neurological Disease Cancer Endocrinology
    Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL23. Bindarit also has anti-inflammatory activity.
  • HY-129773
    Phthalimide-PEG4-PDM-OTBS

    PROTAC Linker Cancer
    Phthalimide-PEG4-PDM-OTBS is a PROTAC linker, which refers to the PEGs composition. Phthalimide-PEG4-PDM-OTBS can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
  • HY-13757A
    Tamoxifen

    ICI 47699; (Z)-Tamoxifen; trans-Tamoxifen

    Estrogen Receptor/ERR HSP Apoptosis Autophagy Cancer
    Tamoxifen (ICI 47699) is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen activates autophagy and induces apoptosis.
  • HY-16749A
    Pexidartinib hydrochloride

    PLX-3397 hydrochloride

    c-Fms c-Kit Apoptosis Cancer
    Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity.
  • HY-16749
    Pexidartinib

    PLX-3397

    c-Fms Apoptosis c-Kit Cancer
    Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity.
  • HY-10322
    Falnidamol

    BIBX 1382

    EGFR Cancer
    Falnidamol (BIBX 1382) is an orally active, selective EGFR tyrosine kinase inhibitor with an IC50 of 3 nM. Falnidamol displays > 1000-fold lower potency against ErbB2 (IC50=3.4 μM) and a range of other related tyrosine kinases (IC50>10 μM). Falnidamol is a pyrimido-pyrimidine compound and has anti-cancer activity.
  • HY-109118
    Masupirdine free base

    SUVN-502 free base

    5-HT Receptor Neurological Disease
    Masupirdine free base (SUVN-502 free base) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine free base (SUVN-502 free base) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease.
  • HY-129364A
    5-A-RU

    5-Amino-6-(D-ribitylamino)uracil

    Others Inflammation/Immunology
    5-A-RU (5-Amino-6-(D-ribitylamino)uracil), a precursor of bacterial Riboflavin, is a mucosal-associated invariant T (MAIT) cells activator. 5-A-RU forms potent MAIT-activating antigens via non-enzymatic reactions with small molecules, such as glyoxal and methylglyoxal, which are derived from other metabolic pathways.
  • HY-111557
    YM-254890

    P2Y Receptor Cardiovascular Disease
    YM-254890 is a selective Gαq/11 protein inhibitor isolated from Chromobacterium sp. YM-254890 shows no inhibition of other G protein subtypes. YM-254890 inhibits platelet aggregation induced by ADP by blocking the P2Y1 signal transduction pathway, with an IC50 value below 0.6 μM.
  • HY-13509
    CCG-50014

    RGS Protein Inflammation/Immunology
    CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test.
  • HY-112306
    Ripretinib

    DCC-2618

    c-Kit PDGFR FLT3 VEGFR Apoptosis Cancer
    Ripretinib (DCC-2618) is an orally bioavailable, selective KIT and PDGFRA switch-control inhibitor. Ripretinib (DCC-2618) targets and binds to both wild-type and mutant forms of KIT and PDGFRA specifically at their switch pocket binding sites, thereby preventing the switch from inactive to active conformations of these kinases and inactivating their wild-type and mutant forms. Ripretinib (DCC-2618) also inhibits multiple other kinase targets, such as FLT3 and KDR (or VEGFR-2). DCC-2618 exerts antineoplastic effect and induces apoptosis.
  • HY-113259
    7α-Hydroxy-4-cholesten-3-one

    Endogenous Metabolite Metabolic Disease
    7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1.
  • HY-10182A
    CHIR-99021 monohydrochloride

    CT99021 monohydrochloride

    GSK-3 Wnt β-catenin Autophagy Cancer
    CHIR-99021 monohydrochloride (CT99021 monohydrochloride) is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 monohydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 monohydrochloride is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 monohydrochloride enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 monohydrochloride induces autophagy.
  • HY-18676
    OSU-T315

    Integrin Autophagy Apoptosis Cancer
    OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). OSU-T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase-dependent apoptosis in an ILK-independent manner. OSU-T315 causes cell death through apoptosis and autophagy.
  • HY-126251
    CDK9-IN-7

    CDK Apoptosis Cancer
    CDK9-IN-7 (compound 21e) is a selective, highly potent, and orally active CDK9/cyclin T inhibitor (IC50=11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM). CDK9-IN-7 shows antitumor activity without obvious toxicity. CDK9-IN-7 induces NSCLC cell apoptosis, arrests the cell cycle in the G2 phase, and suppresses the stemness properties of NSCLC.
  • HY-16659
    EHT 1864

    Ras Neurological Disease Cancer
    EHT 1864 is an inhibitor of Rac family small GTPases. EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation. The Kd values are 40, 50, 60, and 230 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. EHT 1864 also potently inhibits other Rac-dependent transformation processes, Tiam1- and Ras-mediated growth transformation. EHT 1864 prevents Aβ 40 and Aβ 42 production in vivo.
  • HY-130618
    Boc-C1-PEG3-C4-OH

    PROTAC Linker Cancer
    Boc-C1-PEG3-C4-OH is a PROTAC linker, which refers to the Alkyl/ether composition. Boc-C1-PEG3-C4-OH can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
  • HY-10015
    PAP-1

    5-(4-Phenoxybutoxy)psoralen

    Potassium Channel Inflammation/Immunology
    PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a potent, selective, and orally active Kv1.3 blocker (EC50=2 nM). PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 (EC50=45 nM), and further displays 33- to 125-fold selectivity over all other Kv1-family channels. PAP-1 does not exhibit cytotoxic or phototoxic effects.
  • HY-129602
    SD-36

    PROTAC STAT Apoptosis Cancer
    SD-36 is a potent and efficacious PROTAC STAT3 degrader (Kd=~50 nM), and demonstrates high selectivity over other STAT members. SD-36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC50=10 nM). SD-36 exerts robust anti-tumor activity, and achieves complete and long-lasting tumor regression in mouse tumor models. SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of CRBN ligand Lenalidomide for E3 ubiquitin ligase.
  • HY-108596
    BL-1249

    Potassium Channel Inflammation/Immunology
    BL-1249 is a nonsteroidal anti-inflammatory drug (NSAID) and a potassium channel activator. BL-1249 potently activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2) with EC50 values of 5.5 μM and 8.0 μM, respectively. BL-1249 extracellular application activates all TREK subfamily members but has no effect on other K2P subfamilies. BL-1249 exhibits more selective for the bladder (EC50 of 1.26 μM) than vascular tissue (EC50 of 21.0 μM).
  • HY-103022
    Repotrectinib

    TPX-0005

    ROS Trk Receptor ALK Cancer
    Repotrectinib (TPX-0005) is a potent ROS1 (IC50=0.07 nM), TRK (0.83/0.05/0.1 nM=TRKA/B/C) inhibitor. Repotrectinib (TPX-0005) potently inhibits WT ALK (1.01 nM) and mutant ALKs including ALK G1202R (1.26 nM) and ALK L1196M (1.08 nM). It also inhibits a variety of other kinases, including JAK2, LYN, Src, and FAK (1.04, 1.66, 5.3, and 6.96 nM, respectively) .
  • HY-13775
    XL019

    Apoptosis JAK Cancer
    XL019 is a potent,orally active, and selective JAK2 inhibitor, with IC50s of 2.2, 134.3, and 214.2 nM for JAK2, JAK1 and JAK3, respectively. XL019 shows 50-fold or greater selectivity for JAK2, versus a panel of over 100 serine/threonine and tyrosine kinases, including other members of the JAK family. XL019 potently inhibits STAT3 and STAT5 phosphorylation in cells harboring either JAK2V617F or wild-type JAK2.
  • HY-124131
    DS-437

    Histone Methyltransferase Cancer Inflammation/Immunology
    DS-437 is a dual PRMT5/7 inhibitor (IC50s of PRMT5/7=6 μM). DS-437 is selective for PRMT5 and PRMT7 over 29 other human protein-, DNA-, and RNA-methyltransferases. DS-437 is a S-adenosylmethionine (SAM)-competitive inhibitor of PRMT5. DS-437 also inhibits DNMT3A and DNMT3B, with IC50s of 52 and 62 μM, respectively. DS-437 inhibits the methylation of FOXP3.
  • HY-100014
    KDM5A-IN-1

    Histone Demethylase Cancer
    KDM5A-IN-1 is a potent, orally bioavailable pan-histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 45 nM, 56 nM and 55 nM for KDM5A, KDM5B and KDM5C, respectively, and with an EC50 value of 960 nM for PC9 H3K4Me3. KDM5A-IN-1 is significantly less potent against other KDM5B enzymes (1A, 2B, 3B, 4C, 6A, 7B).
  • HY-130619
    Boc-C1-PEG3-C4-OBn

    PROTAC Linker Cancer
    Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) is a PROTAC linker, which refers to the PEG composition. Boc-C1-PEG3-C4-OBn can be used in the synthesis of a series of PROTACs, such as PROTAC SGK3 degrader-1 (HY-125878). PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
  • HY-N0818
    Chikusetsusaponin Iva

    Calenduloside F

    Others Others
    Chikusetsusaponin IVa a major active ingredient of triterpenoid saponins, exerts antithrombotic effects, including minor hemorrhagic events.
  • HY-W041171
    3-Chloro-L-tyrosine

    Endogenous Metabolite Others
    3-Chloro-L-tyrosine is a specific marker of myeloperoxidase-catalyzed oxidation, and is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.
  • HY-N5157
    Licorisoflavan I

    Others Others
    Licorisoflavan I, an isoflavone, mainly derived from Glycyrrhiza uralensis Fisch..
  • HY-18299B
    (S)-Purvalanol B

    (S)-NG 95

    Others Others
    (S)-Purvalanol B is the S enantiomer of Purvalanol B. Purvalanol B is a cyclin-dependent kinase inhibitor.
  • HY-N0255
    alpha-Hederin

    α-Hederin

    Apoptosis Others
    alpha-Hederin (α-Hederin) is a water-soluble pentacyclic triterpenoid saponin, possessing several biological properties such as antispasmodic, moliscicidic, anthelmithic and inhibiting cell proliferation,
  • HY-A0020S
    Eldecalcitol-d6

    Others Others
    Eldecalcitol-d6 is the deuterium labeled Eldecalcitol. Eldecalcitol is an orally administered analogue of active vitamin D used in the treatment of osteoporosis.
  • HY-12695B
    5'-GTP trisodium salt hydrate

    Guanosine 5'-triphosphate trisodium salt hydrate

    Others Others
    5'-GTP trisodium salt hydrate is an activator of the signal transducing G proteins and also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.
  • HY-I0726
    Enantiomer of Sofosbuvir

    Others Others
    Enantiomer of Sofosbuvir is an enantiomer of Sofosbuvir, a prescription medicine for the treatment of patients with chronic hepatitis C. There is no biological activity report on enantiomer of Sofosbuvir until now.
  • HY-N0853
    Alisol A

    Alisol-A

    Autophagy Others
    Alisol A is a natural product.
  • HY-N4327
    Eurycomalactone

    NF-κB Others
    Eurycomalactone is a natural product found in Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor, with an IC50 of 0.5 μM. Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-induced degradation of IκBα or the phosphorylation of IKKα/β and IκBα.
  • HY-N1914
    Ergothioneine

    L-(+)-Ergothioneine

    Others Others
    Ergothioneine, an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant.
  • HY-W008393
    (-)-Corey lactone diol

    Others Others
    (-)-Corey lactone diol is a reduced version of corey aldehyde. A building block in the chemical synthesis.
  • HY-N1384
    Ambroxide

    Others Others
    Ambroxide is a naturally occurring terpenoid. Ambroxide is one of the key constituents of ambergris.
  • HY-N0046
    Notoginsenoside Fe

    Notoginseng triterpenes; Ginsenoside Mb

    Others Others
    Notoginsenoside Fe is a natural compound isolated from Panax japlcus var.
  • HY-118651
    Griseoluteic acid

    Bacterial Others
    Griseoluteic acid, a phenazine antibiotic, is originally isolated from S. griseoluteus. Griseoluteic acid is a breakdown product of griseolutein A and B.
  • HY-128434
    L-​Leucyl-​L-​alanine

    Endogenous Metabolite Others
    L-Leucyl-L-alanine is a simple dipeptide composed of L-leucine and L-alanine.
  • HY-N1962
    Ophiopojaponin C

    Others Others
    Ophiopojaponin C is a naturally occurring C29 steroidal glycoside isolated from the tubers of O. japonicas.
  • HY-34204
    2'-Hydroxy-4'-methylacetophenone

    Others Others
    2'-Hydroxy-4'-methylacetophenone, a phenolic compound isolated from Angelicae koreana roots possesses acaricidal property. It could be used in the preparation of 4’-methyl-2’-[(p-tolylsulfonyl) oxy] acetophenone.
  • HY-135586
    Raloxifene N-Oxide

    Drug Metabolite Others
    Raloxifene N-Oxide is a Raloxifene oxidative degradation product.
  • HY-N0204
    Pulchinenoside A

    Anemoside A3

    Others Others
    Pulchinenoside A is a natural triterpenoid saponin that enhances synaptic plasticity in the adult mouse hippocampus and facilitates spatial memory in adult mice.
  • HY-B0914
    10-Undecenoic acid

    Undecylenic acid

    Fungal Others
    10-Undecenoic acid was used as a starting reagent in the syntheses of Pheromone (11Z)-hexadecenal.
  • HY-119687
    Bifenazate

    GABA Receptor Others
    Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm. Bifenazate is a positive allosteric modulator of GABA receptor.
  • HY-N0520
    Calycosin-7-O-β-D-glucoside

    Reactive Oxygen Species Others
    Calycosin-7-O-β-D-glucoside, a melanin biosynthesis inhibitor, is isolated from the methanol extract of astragalus.
  • HY-15321S
    Etoricoxib D4

    MK-0663 D4; L-791456 D4

    COX Others
    Etoricoxib D4 (MK-0663 D4) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.
  • HY-16912
    SP-420

    Others Others
    SP-420 is a desferrithiocin analogue with iron-clearing efficiency with ICE value of 26.7; more potent than desferrithiocin.
  • HY-113301
    Hexacosanoic acid

    Endogenous Metabolite Others
    Hexacosanoic acid is a long-chain fatty acid related to various diseases such as adrenoleukodystrophy (ALD), adrenomyeloneuropathy (AMN) and atherosclerosis.
  • HY-B1260
    Cetrimonium bromide

    Cetyltrimethylammonium bromide; Hexadecyltrimethylammonium bromide; CTAB

    Others Others
    Cetrimonium bromide is an amine based cationic quaternary surfactant, is one of the components of the topical antiseptic Cetrimide.
  • HY-113143
    Galactose 1-phosphate

    Endogenous Metabolite Others
    Galactose 1-phosphate is an intermediate in the galactose metabolism and nucleotide sugars.
  • HY-104011
    L-Pyrrolysine

    Others Others
    L-Pyrrolysine is the 22nd genetically encoded amino acid.
  • HY-N4324
    cis-p-Menthan-1,8-diol

    4-p-Menthan-1,8-diol

    Others Others
    cis-​p-​Menthan-​1,​8-​diol is a natural menthane monoterpenoid.
  • HY-N6838
    1,1,1,1-Kestohexaose

    Others Others
    1,1,1,1-Kestohexaose is a fructan oligomer isolated from Poa ampla.
  • HY-B0985
    Phenazopyridine hydrochloride

    Others Others
    Phenazopyridine hydrochloride is a chemical, which has a local analgesic effect, often used to alleviate the pain, irritation, discomfort, or urgency caused by urinary tract infections, surgery, or injury to the urinary tract.
  • HY-112114
    DTPA-DAB2

    Others Others
    DAB2-DTPA is a conjugate of DTPA with two DAB used in the photooxidation experiments.
  • HY-12243
    CID-797718

    Others Others
    CID-797718 is a compound with unknown details.
  • HY-113306
    1-Methyladenine

    Endogenous Metabolite Others
    1-Methyladenine is a product of alkylation damage in DNA which can be repaired by damage reversal by oxidative demethylation.
  • HY-128708
    ACPK

    Others Others
    ACPK is a pyrrolysine analogue bearing an azide residue.
  • HY-B2236
    DL-Lysine

    (±)-2,6-Diaminocaproic acid

    Others Others
    DL-Lysine (Lysine) is an α-amino acid that is used in the biosynthesis of proteins.
  • HY-113004
    3-Hydroxyvaleric acid

    Endogenous Metabolite Others
    3-Hydroxyvaleric acid is a 5-carbon ketone body. 3-Hydroxyvaleric acid is anaplerotic, meaning it can refill the pool of TCA cycle intermediates.
  • HY-12305A
    (R)-Q-VD-OPh

    (R)-QVD-OPH; (R)-Quinoline-Val-Asp-Difluorophenoxymethylketone

    Others Others
    (R)-Q-VD-OPh ((R)-QVD-OPH) is the less active enantiomer of Q-VD-OPha. Q-VD-OPha is an irreversible pan-caspase inhibitor with potent antiapoptotic properties.
  • HY-N0379
    D-Mannose

    Endogenous Metabolite Others
    D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific proteins.
  • HY-135151
    Difluoro atorvastatin

    Fluoroatorvastatin

    Others Others
    Difluoro atorvastatin (Fluoroatorvastatin) is an impurity of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.
  • HY-N4212
    Astraganoside

    Others Others
    Astraganoside, an isoflavane compound, isolated from the roots of Astragalus membranaceus (known as ‘‘Huangqi’’).
  • HY-N4034
    Hopane-3β,22-diol

    Others Others
    Hopane-3β,22-diol (compound 74) is a hopane isolated from A. mariesii.
  • HY-123962
    G6PD activator AG1

    Others Others
    G6PD activator AG1 is a glucose-6-phosphate dehydrogenase (G6PD) activator with an EC50 of 3 µΜ, extracted from patent WO2019023264A1, compound AG1.
  • HY-B0922
    Dicloralurea

    DCU; Dichlorolurea

    Others Others
    Dicloralurea is a veterinary food additive that inhibits methane production in herbicide ruminants, acts as a growth stimulant.
  • HY-112398
    GSK1379725A

    Others Others
    GSK1379725A is a selective BPTF ligand with a Kd of 2.8 uM, showing no binding activity for Brd4.
  • HY-112803
    GNE-371

    DNA/RNA Synthesis Others
    GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC50 of 10 nM for TAF1(2).
  • HY-B1023
    Mexenone

    Others Others
    Mexenone is a benzophenone-derived sunscreening agent.
  • HY-N6903
    Geoside

    Gein; Eugenyl vicianoside

    Others Others
    Geoside (Gein) is a natural compound isolated from stevia rebaudiana.
  • HY-N6840
    Xylotetraose

    Others Others
    Xylotetraose is a hydrolysis product of Xylan. Xylan is a polysaccharide made from units of xylose and contains predominantly β-D-xylose units linked as in cellulose. Xylotetraose can be used for enzyme biochemical analysis.
  • HY-B1181A
    Hydrastinine

    Others Others
    Hydrastinine is a major alkaloid constituent in goldenseal (Hydrastis canadensis). Hydrastinine can be used as a haemostatic agent.
  • HY-N4280
    7,8-Dimethoxycoumarin

    Others Others
    7,8-Dimethoxycoumarin (Daphnetin dimethyl ether) is a coumarin from Artemisia caruifolia.
  • HY-W052144
    (±) Anabasine

    Endogenous Metabolite Others
    (±) Anabasine is a biphasic muscle relaxant.
  • HY-N0597
    Panaxatriol

    Others Others
    Panaxatriol is a natural product that can relieve myelosuppression induced by radiation injury.
  • HY-111664A
    (S)​-​(-​)​-​Citronellal

    (-​)​-​Citronellal

    Endogenous Metabolite Others
    (S)-(-)-Citronellal ((-)-Citronellal) is a monoterpenoid compound found in Corymbia citriodora and Cymbopogon nardus essential oils.
  • HY-B0926A
    Sodium diatrizoate

    Diatrizoic acid sodium salt; Sodium amidotrizoate

    Others Others
    Sodium diatrizoate is an iodinated radiocontrast agent.
  • HY-116284
    Methyl β-D-glucopyranoside

    Methyl β-D-glucoside

    Others Others
    Methyl β-D-glucopyranoside is used to synthesize natural glycophenolics via enzymatic caffeoylation.
  • HY-N6957
    8-Keto-berberine

    Others Others
    8-Keto-berberine (compound 29) is a non-naturally occurring 11, 12-oxygenated protoberberine derived from naturally occurring 9, 10-oxygenated protoberberine.
  • HY-N1150
    Thymidine

    DThyd; NSC 21548

    DNA/RNA Synthesis Endogenous Metabolite Others
    Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.
  • HY-U00324
    p38 MAPK-IN-2

    p38 MAPK Autophagy Others
    p38 MAPK-IN-2 is an inhibitor of p38 kinase.
  • HY-111378
    Casein Kinase II Inhibitor IV

    Casein Kinase Others
    Casein Kinase II Inhibitor IV is a small-molecule inducer of epidermal keratinocyte differentiation.
  • HY-113410
    3-Methylglutaric acid

    Endogenous Metabolite Others
    3-Methylglutaric acid is a leucine metabolite.
  • HY-113801
    N-(3-Oxooctanoyl)-DL-homoserine lactone

    (Rac)-3-oxo-C8-HSL

    Others Others
    N-(3-Oxooctanoyl)-DL-homoserine lacton is a member of N-Acyl homoserine lactone (AHL) from gram-negative bacteria, with stereochemistry-dependent growth regulatory activity for roots .
  • HY-B0032S
    Lurasidone D8 Hydrochloride

    SM-13496 D8

    Others Others
    Lurasidone D8 Hydrochloride is the deuterium labeled Lurasidone, which is an inhibitor of Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C.
  • HY-N1132A
    D-(+)-Trehalose dihydrate

    D-Trehalose dihydrate; α,α-Trehalose dihydrate

    Others Others
    D-(+)-Trehalose dihydrate, isolated from Saccharomyces cerevisiae, can be used as a food ingredient and pharmaceutical excipient.
  • HY-112501
    Codon readthrough inducer 1

    Others Others
    Codon readthrough inducer 1, containing pyrimidine bases, shows good readthrough activity.
  • HY-A0007S
    Rotigotine D7 Hydrochloride

    N-0923 D7 Hydrochloride

    Dopamine Receptor Others
    Rotigotine D7 Hydrochloride is the deuterium labeled Rotigotine(N-0923), which is a dopamine D2 and D3 receptor agonist.
  • HY-N2358
    Blumeatin

    Others Others
    Blumeatin, isolated from Blumea balsamifera DC, could protect liver against injury induced by CCl4 and thioacetamide (TAA).
  • HY-N4099
    Luteolin-3-O-beta-D-glucuronide

    Others Others
    Luteolin-3-O-beta-D-glucuronide is a luteolin glucosiduronic acid consisting of luteolin having a beta-D-glucosiduronic acid residue attached at the 3'-position.
  • HY-N6837
    Fructo-​oligosaccharide DP7/GF6

    Others Others
    Fructo-oligosaccharide DP7/GF6 belongs to fructooligosaccharides (FOS) with degree of polymerization (DP=7). Fructo-oligosaccharides (FOS) are composed of 6 fructose units linked by (2→1)-β-glycosidic bonds and having a single D-glucosyl unit at the non-reducing end.
  • HY-128720
    Diethyl oxalpropionate

    Endogenous Metabolite Others
    Diethyl oxalpropionate is an intermediate for poly((R,S)-3,3-dimethylmalic acid) (PDMMLA) derivative synthesis. PDMMLA derivative can be used in synthesis of nanoparticles and study of warfarin encapsulation and controlled release.
  • HY-N7203
    N-Caffeoyl O-methyltyramine

    Glucosidase Others
    N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase (IC50 of 103.58 μM).
  • HY-113440
    5-Methoxytryptophol

    Endogenous Metabolite Others
    5-Methoxytryptophol is a natural indole present in the pineal gland.
  • HY-111841
    PROTAC CRABP-II Degrader-2

    SNIPER PROTAC Others
    PROTAC CRABP-II Degrader-2 is a potent cellular retinoic acid binding protein (CRABP-II) degrader based on cIAp1.
  • HY-N6254
    Moluccanin

    Others Others
    Moluccanin is a coumarinolignoid from Aleurites moluccana.
  • HY-B0797
    Etretinate

    Ro 10-9359

    Apoptosis Others
    Etretinate(Ro 10-9359) is a second-generation retinoid that has the potential for severe psoriasis treatment.
  • HY-N3029
    Noreugenin

    Others Others
    Noreugenin, 5,7-dihydroxy-2-methyl-4H-chromen-4-one, is a new chromone from Hymenocallis littoralis Salisb. (Amaryllidaceae).
  • HY-N7076
    Aleuritic acid

    (±)-erythro-Aleuritic acid; α-Aleuritic acid

    Others Others
    Aleuritic acid ((±)-erythro-Aleuritic acid) is a major ingredient in shellac and used in the perfumery industry.
  • HY-15559
    Hoechst 33342

    bisBenzimide H 33342; HOE 33342

    Autophagy Others
    Hoechst 33342 is a DNA minor groove binder used fluorochrome for visualizing cellular DNA.
  • HY-107910
    Hyaluronidase

    Hyaluronate 4-glycanohydrolase; Hyaluronoglucosaminidase

    Others Others
    Hyaluronidase (Hyaluronate 4-glycanohydrolase; Hyaluronoglucosaminidase) is a naturally occurring enzyme that depolymerizes hyaluronic acid by cleavage of glycosidic bonds and has been utilized in ophthalmic surgery.
  • HY-N2234
    Ganolactone B

    Others Others
    Ganolactone B is a lanostane-type triterpene isolated from the fruiting bodies of G. sinense.
  • HY-N6770
    Curvularin

    (S)-Curvularin

    NO Synthase Others
    Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM.
  • HY-103597
    Thalidomide-O-COOH

    Cereblon ligand 3; E3 ligase Ligand 3

    Ligand for E3 Ligase Others
    Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs.
  • HY-113138
    3-Methyluridine

    Endogenous Metabolite Others
    3-Methyluridine is a modified nucleoside of cellular RNA.
  • HY-P1860
    TNF-α (31-45), human

    Others Others
    TNF-α (31-45), human is a peptide of tumor necrosis factor-α.
  • HY-B0787
    Gadodiamide

    Others Others
    Gadodiamide(Omniscan) is a gadolinium-based MRI contrast agent, used in MR imaging procedures to assist in the visualization of blood vessels.
  • HY-112103
    6-(γ,γ-Dimethylallylamino)purine

    N6-(2-lsopentenyl)adenine

    Others Others
    6-(γ,γ-Dimethylallylamino)purine is a plant growth substance.
  • HY-N0454
    DL-Arginine

    Others Others
    DL-Arginine is used in physicochemical analysis of amino acid complexation dynamics and crystal structure formations.
  • HY-112829
    FASN-IN-2

    Fatty Acid Synthase (FAS) Others
    FASN-IN-2 is a Fatty Acid Synthase (FASN) inhibitor extracted from patent WO2012122391A1, compound 152, has an IC50 of 0.052 μM and an EC50 of 0.072 μM.
  • HY-B2127
    Azobenzene

    Others Others
    Azobenzene can be used as an optical trigger for the design and synthesis of a large variety of photoresponsive systems.
  • HY-N0615
    Notoginsenoside R1

    Sanchinoside R1; Sanqi glucoside R1

    Amyloid-β Others
    Notoginsenoside R1, the main bioactive component in panaxnotoginseng, is reported to have some neuronal protective, antihypertensive effects.
  • HY-17373S
    Posaconazole-D5

    SCH 56592-D5

    Fungal Others
    Posaconazole-D5 is a deuterium-labeled form of Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
  • HY-15005B
    Sofosbuvir impurity C

    HCV Others
    Sofosbuvir impurity C is the less active impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
  • HY-13728A
    (R)-Plevitrexed

    (R)-ZD 9331; (R)-BGC9331

    Others Others
    (R)-Plevitrexed ((R)-ZD 9331; (R)-BGC9331) is a less active enantiomer of Plevitrexed. Plevitrexed is an orally active and potent thymidylate synthase (TS) inhibitor.
  • HY-N4125
    Dehydroeburicoic acid monoacetate

    3-O-Acetyldehydroeburicoic acid

    Others Others
    Dehydroeburicoic acid monoacetate (Compound 18) is a lanostane triterpenoid isolated from Wolfiporia cocos.
  • HY-119821
    Terphenyllin

    Glucosidase Others
    Terphenyllin is a naturally abundant p-terphenyl metabolite isolated from the coral derived fungus Aspergillus candidus, has significant α-glucosidase inhibitory activity.
  • HY-A0092
    Trimethadione

    3,5,5,-Trimethyloxazolidine-2,4-dione

    Calcium Channel Others
    Trimethadione is an oxazolidinedione anticonvulsant; commonly used to treat epileptic conditions.
  • HY-N4008
    Iriflophenone 3-C-glucoside

    Iriflophenone 3-C-β-D-glucopyranoside

    Others Others
    Iriflophenone 3-C-β-D-glucopyranoside, isolated from Cyclopia genistoides, has antioxidant activity.
  • HY-101075
    L-690330

    Phosphatase Others
    L-690330 is a competitive inhibitor of inositol monophosphatase (IMPase) with Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 exhibits 10-fold more sensitive than mouse and rat IMPase.
  • HY-Y0202
    Pyrocatechuic acid

    Catecholcarboxylic acid; NSC 27435

    Endogenous Metabolite Others
    Pyrocatechuic acid is a normal human benzoic acid metabolite found in plasma, and has increased levels after aspirin ingestion.
  • HY-N0057
    3,4-Dicaffeoylquinic acid

    Isochlorogenic acid B

    Others Others
    3,4-Dicaffeoylquinic acid is a reference substance of a common phytochemical found in Echinacea (Echinacea sp.); dietary supplement, herb, or plant testing applications with this reference material include material characterization, adulterant identification, or method validation.
  • HY-112633
    SMN-C3

    DNA/RNA Synthesis Others
    SMN-C3 is an orally active SMN2 splicing modulator and has the potential to treat spinal muscular atrophy (SMA).
  • HY-N2286
    Kushenol I

    Others Others
    Kushenol I is a natural compound isolated from the roots of Sophora flavescens.
  • HY-109139
    Taminadenant

    Adenosine Receptor Others
    Taminadenant is an antagonist of adenosine receptor.
  • HY-N0464
    D-(-)-Quinic acid

    Others Others
    D-(-)-Quinic acid is a cyclohexanecarboxylic acid and is implicated in the perceived acidity of coffee.
  • HY-17391
    Pamabrom

    Others Others
    Pamabron is a common over-the-counter diuretic used for relief of menstrual-associated symptoms.
  • HY-101412
    2-(Methylamino)-1H-purin-6(7H)-one

    N2-methylguanine

    Bacterial DNA/RNA Synthesis Endogenous Metabolite Others
    2-(Methylamino)-1H-purin-6(7H)-one (N2-Methylguanine) is a modified nucleoside. 2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids.
  • HY-B0986
    Hexylresorcinol

    4-Hexylresorcinol

    Parasite Tyrosinase Others
    Hexylresorcinol is an organic compound with local anaesthetic, antiseptic and anthelmintic properties, is a potent inhibitor of mushroom tyrosinase, causing 90% loss of activity at 100 μM.
  • HY-12303
    OAC1

    Oct3/4 Others
    OAC1 is a Octamer-binding transcription factor 4 (Oct4)-activating compound; enhances the iPSC reprogramming efficiency and accelerated the reprogramming process.
  • HY-N6831
    Xylohexaose

    Others Others
    Xylohexaose is a hexasaccharide consisting of six xylose residues.
  • HY-100888A
    (R)-Simurosertib

    (R)-TAK-931

    Others Others
    (R)-Simurosertib ((R)-TAK-931) is the (R)-enantiomer of Simurosertib, Simurosertib (TAK-931) is a selective cycle 7 (CDC7) kinase inhibitor, with an IC50<0.3 nM.
  • HY-Y0051
    5-Hydroxymethylfurfural

    2-Hydroxymethyl-5-furfural; 2-Formyl-5-hydroxymethylfuran

    Fungal Others
    5-Hydroxymethylfurfural (2-Hydroxymethyl-5-furfural), derived from lignocellulosic biomass, inhibits yeast growth and fermentation as stressors.
  • HY-112757
    DLinDMA

    Others Others
    DLinDMA is a key lipid component of stable nucleic acid lipid particles as a benchmark.
  • HY-N7264
    7α-Hydroxycholesterol

    Others Others
    7α-Hydroxycholesterol is a cholesterol oxide and is formed by both enzymatic and non-enzymatic oxidation. 7α-Hydroxycholesterol can be used as a biomarker for lipid peroxidation.
  • HY-A0020
    Eldecalcitol

    ED-71; 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3

    VD/VDR Others
    Eldecalcitol (ED-71) is an analog of 1,25-dihydroxyvitamin D3 that improves bone mineral density.
  • HY-N1887
    4-Allylcatechol

    Hydroxychavicol; 4-Allylpyrocatechol

    Others Others
    4-Allylcatechol (4-Allylpyrocatechol, Hydroxychavicol) is an intermediate to synthetic safrole.
  • HY-107379
    AKR1C3-IN-1

    Others Others
    AKR1C3-IN-1 is a potent, highly selective inhibitor of AKR1C3, with an IC50 of 13 nM.
  • HY-118607
    VU041

    Potassium Channel Others
    VU041 is a first submicromolar-affinity inhibitor of Anopheles (An.) gambiae and Aedes (Ae.) aegypti inward rectifier potassium 1 (Kir1) channels with IC50 values of 2.5 μM and 1.7 μM, respectively. VU041 inhibits appreciably is mammalian Kir2.1 (IC50 of 12.7 μM), and has less inhibitory effect on mammalian Kir1.1, Kir4.1, Kir6.2/SUR1, and Kir7.1. VU041 also induces impaired Malpighian tubule function.
  • HY-N2525
    Teucvidin

    Others Others
    Teucvidin is a diterpenoid from Teucrium species.
  • HY-N1072
    Wilforgine

    Others Others
    Wilforgine is a bioactive sesquiterpene alkaloid in Tripterygium wilfordii Hook. F. Wilforgine can induce microstructural and ultrastructural changes in the muscles of Mythimna separata larvae, and the sites of action are proposed to be calcium receptors or channels in the muscular system.
  • HY-16935
    Mavatrep

    JNJ-39439335

    TRP Channel Others
    Mavatrep is an orally bioavailable TRPV1 antagonist (Ki=6.5 nM), exhibits minimal effect on the enzymatic activity (IC50 > 25 μM) of CYP isoforms 3A4, 1A2, and 2D6.
  • HY-N1932
    Bayogenin

    Others Others
    Bayogenin is an alfalfa saponin, shows moderate potency of glycogen phosphorylase inhibition.
  • HY-13250B
    Silvestrol aglycone (enantiomer)

    Others Others
    Silvestrol aglycone enantiomer is a cyclopenta benzofuran core phenol.
  • HY-17516
    Tolfenpyrad

    Bacterial Others
    Tolfenpyrad is a pesticide that was first approved in 2002 in Japan.
  • HY-135580A
    Raloxifene Bismethyl Ether hydrochloride

    Others Others
    Raloxifene Bismethyl Ether hydrochloride is a metabolite of Raloxifene and an estrogen receptor inactive compound on which both hydroxyl groups are absent.
  • HY-12695
    5'-GTP trisodium salt

    Guanosine 5'-triphosphate trisodium salt

    Endogenous Metabolite Others
    5'-GTP trisodium salt (Guanosine 5'-triphosphate trisodium salt) is an activator of the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades.
  • HY-105917
    Endovion

    NS3728

    Chloride Channel Others
    Endovion (NS3728) is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor.
  • HY-15286
    sodium 4-pentynoate

    Others Others
    sodium 4-pentynoate is a alkynylacetate analogue; can be metabolically incorporated onto cellular proteins through biosynthetic mechanisms for profiling of acetylated proteins in diverse cell types.
  • HY-N2365
    N-Benzylpalmitamide

    N-Benzylhexadecanamide; Macamide 1

    FAAH Autophagy Others
    N-Benzylpalmitamide is a macamide isolated from Lepidium meyenii, acts as an inhibitor of fatty acid amide hydrolase (FAAH).
  • HY-10013B
    Taranabant ((1R,2R)stereoisomer)

    MK0364 (1R,2R)stereoisomer

    Cannabinoid Receptor Others
    Taranabant (1R,2R)stereoisomer is the R-enantiomer of Taranabant. Taranabant is a highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist.
  • HY-135406
    (3R,5R)-Rosuvastatin Lactone

    Others Others
    (3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone.
  • HY-N2278
    Kushenol A

    Leachianone E

    Tyrosinase Others
    Kushenol A is isolated from the root of Sophora flavescent, a non-competitive tyrosinase inhibitor with IC50 and Ki values of 1.1 μM and 0.4 μM, respectively. Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase and beta-amylase. Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging.
  • HY-N0621
    Morin

    Others Others
    Morin, a plant-derived flavonoid, possesses low antioxidant activity. Morin is a fluorescing chelating agent used in aluminum speciation.
  • HY-17521
    Flumorph

    SYP-L190

    Fungal Others
    Flumorph(SYP-L190) is a carboxylic acid amide (CAA) fungicide.
  • HY-128710
    2'-Fluorothymidine

    2'-​Deoxy-​2'-​fluoro-​5-​Methyluridine

    Others Others
    2'-Fluorothymidine (2'-Fluoro-2'-deoxythymidine), a bioisostere of both thymidine (TdR) and methyluridine, is a putative highly selective substrate for thymidine kinase type 2 (TK2).
  • HY-N6982
    Licoricesaponin A3

    Others Others
    Licoricesaponin A3 is a terpenoid saponin identified from licorice.
  • HY-12885C
    ADU-S100 enantiomer Ammonium salt

    Others Others
    ADU-S100 enantiomer (Ammonium salt) is the less active enantiomer of ADU-S100. ADU-S100 is an activator of stimulator of interferon genes (STING).
  • HY-N2360
    Hinokiflavone

    E1/E2/E3 Enzyme Others
    Hinokiflavone is a novel modulator of pre-mRNA splicing activity in vitro and in cellulo. Hinokiflavone blocks splicing of pre-mRNA substrates by inhibiting spliceosome assembly, specifically preventing B complex formation. Hinokiflavone is a SUMO protease inhibitor, inhibiting sentrin-specific protease 1 (SENP1) activity.
  • HY-17531
    Pyraclonil

    Others Others
    Pyraclonil is a herbicide agent.
  • HY-18673
    PROTO-1

    Others Others
    PROTO-1 shows significant protection of hair cells, with HC50(concentration that would produce 50% hair cell survival) of 1 μM-10 μM (1 μM≤HC50≤10 μM).
  • HY-B1407
    Phthalylsulfathiazole

    N4-Phthalylsulfathiazole

    Bacterial Others
    Phthalylsulfathiazole is a kind of sulfonamides used as an antibacterial drug.
  • HY-18714
    BRD7116

    Others Others
    BRD7116 competitively binds to bacterial DNA gyrase, exhibits an EC50 of 200 nM for LSCe cells, with cell-non-autonomous anti-leukemia activity.
  • HY-17021B
    Esomeprazole potassium salt

    (S)-Omeprazole potassium

    Proton Pump Others
    Esomeprazole potassium salt is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.
  • HY-Y0694
    2',4'-Dihydroxyacetophenone

    Resacetophenone; 1-​(2,​4-​Dihydroxyphenyl)​ethanone

    Endogenous Metabolite Others
    2',4'-Dihydroxyacetophenone (Resacetophenone) is acetophenone carrying hydroxy substituents at positions 2' and 4'. A plant metabolite.
  • HY-N1463
    Luteolin 7-O-glucuronide

    Luteolin 7-glucuronide

    MMP Others
    Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively.
  • HY-12693
    R(+)-IAA-94

    R(+)-Methylindazone

    Chloride Channel Others
    R(+)-IAA-94 is a potent indanyloxyacetic acid blocker of epithelial chloride channels.
  • HY-N3524
    Calycanthoside

    Others Others
    Calycanthoside is a natural compound isolated from Angelica tenuissima.
  • HY-N6262
    20(S),24(R)-Ocotillol

    Others Others
    20(S),24(R)-Ocotillol is isolated from Panax ginseng.
  • HY-N6852
    11-Oxomogroside IIe

    Others Others
    11-Oxomogroside IIe is a triterpene glycoside isolated from Siraitia grosvenori.
  • HY-133110
    Afatinib N-Oxide

    Others Others
    Afatinib N-Oxide is a impurity of Afatinib dimaleate in oxidative degradation. Afatinib dimaleate is an irreversible EGFR family inhibitor.
  • HY-Y0946
    Acetamide

    Endogenous Metabolite Others
    Acetamide is used primarily as a solvent and a plasticizer.
  • HY-17641
    Olumacostat glasaretil

    Acetyl-CoA Carboxylase Others
    Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC).
  • HY-17517
    Tiadinil

    Bacterial Others
    Tiadinil is a plant activator of systemic acquired resistance, boosts the production of herbivore-induced plant volatiles; fungicide.
  • HY-N7088
    Raffinose

    Melitose

    Others Others
    Raffinose (Melitose), a non-digestible short-chain oligosaccharide, is a trisaccharide composed of galactose, glucose, and fructose and can be found in many plants. Raffinose (Melitose) can be hydrolyzed to D-galactose and sucrose by the enzyme α-galactosidase (α-GAL).
  • HY-13813
    Blebbistatin

    Myosin Others
    Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function.
  • HY-N4204
    Daidzein diacetate

    Others Others
    Daidzein diacetate is a derivative of Daidzein that is a soy isoflavone.
  • HY-12692
    DO3A tert-Butyl ester

    DO3A tert-butyl; DO3A-t-Bu-ester

    Others Others
    DOTA tert-Butyl ester is a benxyl derivative of the cyclic tosamide; can be nitrated directly; is more convenient to incorporate the nitro group after deprotection lithium aluminum hydride.
  • HY-18684
    SIBA

    5'-Isobutylthioadenosine; 5'-Deoxy-5'-isobutylthioadenosine

    Others Others
    SIBA selectively inhibits spermine synthase, IC50=8 uM.
  • HY-N6779
    Patulin

    Terinin

    Apoptosis Others
    Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, is suspected to be clastogenic, mutagenic, teratogenic and cytotoxic. Patulin (Terinin) induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage.
  • HY-G0016S1
    N-acetyl Dapsone (D4')

    MADDS D4'

    Others Others
    N-acetyl Dapsone (D4') is the deuterium labeled N-acetyl Dapsone, which is a metabolite of Dapsone.
  • HY-B1053
    Iotalamic acid

    Iothalamic acid

    Others Others
    Lotalamic acid (Iothalamic acid) is a molecule used as a contrast medium.
  • HY-F0001
    NADH disodium salt

    Disodium NADH

    Endogenous Metabolite Others
    NADH disodium salt is a coenzyme of a large number of oxidoreductases. NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, beta-oxidation and the citric acid cycle.
  • HY-16689
    VU 0240551

    Potassium Channel Others
    VU 0240551 is a small molecule inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 560 nM for K+ uptake assay in KCC2-overexpressing cells).
  • HY-20588
    CRAC intermediate 2

    CRAC Channel Others
    CRAC intermediate 2 is a intermediate compound for CRAC inhibitor synthesis, extracted from patent WO 2013059666A1.
  • HY-113972
    Methyl mycophenolate

    Others Others
    Methyl mycophenolate is a methyl ester of mycophenolic acid and is also found in marine-derived fungus Phaeosphaeria spartinae.
  • HY-N5084
    Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside

    Others Others
    Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside is a flavanone compound.
  • HY-18102A
    GLPG0492 R enantiomer

    Androgen Receptor Others
    GLPG0492 R enantiomer is the R enantiomer of GLPG-0492, which is a novel selective androgen receptor modulator.
  • HY-15979A
    H-89 dihydrochloride

    Protein kinase inhibitor H-89 dihydrochloride

    PKA Autophagy Others
    H-89 dihydrochloride is a potent and selective inhibitor of protein kinase A (PKA) with an IC50 of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase.
  • HY-N0821
    Lithospermoside

    Griffonin

    Others Others
    Lithospermoside (Griffonin) is a nature product isolated from the stem bark of Ochna schweinfurthiana F. Hoffm.
  • HY-P1868A
    α2β1 Integrin Ligand Peptide (TFA)

    Integrin Others
    α2β1 Integrin Ligand Peptide TFA interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors.
  • HY-N0092
    Inosine

    Endogenous Metabolite Others
    Inosine, an endogenous purine nucleoside, has immunomodulatory, neuroprotective, and analgesic properties.
  • HY-N1515
    Ganoderenic acid C

    Others Others
    Ganoderenic acid C is a triterpenoid isolated from Ganoderma lingzhi. Ganoderenic acid C is abundant in fruit bodies at an early growth stage.
  • HY-W010128
    6-(Dimethylamino)purine

    6-Dimethylaminopurine

    CDK Others
    6-(Dimethylamino)purine is a dual inhibitor of protein kinase and CDK.
  • HY-N6956
    5-MethoxyPinocembroside

    Others Others
    5-MethoxyPinocembroside is a flavonoid isolated from Penthorumchinense Pursh.
  • HY-N0652
    2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside

    2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside

    Others Others
    2,3,4',5-tetrahydroxystilbene 2-O-D-glucoside isolats from the roots of Polygonum species, inhibits the formation of 5-HETE, HHT and thromboxane B2, although less strongly.
  • HY-B1162
    Sulisobenzone

    Benzophenone-4

    Others Others
    Sulisobenzone is an ingredient in some sunscreens which protects the skin from damage by UVB and short-wave UVA ultraviolet light.
  • HY-B0876
    Fomepizole

    4-Methylpyrazole

    Others Others
    Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase which plays a key role in the metabolism of ethylene glycol and methanol.
  • HY-N2131
    Isosakuranetin

    Others Others
    Isosakuranetin is a flavanone flavonoid which can be found in the fruit of Citrus bergamia.
  • HY-N4082
    Neotriptophenolide

    Others Others
    Neotriptophenolide is a sesquiterpene pyridine alkaloid isolated from the root barks of Tripterygium hypoglaucum.
  • HY-23524
    HSL-IN-3

    Others Others
    HSL-IN-3 (example 42), a boronic acid ester derivative, is an inhibitor of hormone-sensitive lipase (HSL).
  • HY-113293A
    Estrone sulfate potassium

    Endogenous Metabolite Others
    Estrone sulfate potassium is a natural endogenous steroid and is an estrogen ester and conjugate.
  • HY-12767S
    4-Hydroxyphenyl Carvedilol D5

    4-Hydroxycarvedilol D5

    Others Others
    4-Hydroxyphenyl Carvedilol D5 is the deuterium labeled 4-Hydroxyphenyl Carvedilol.
  • HY-124780
    HOOCCH2O-PEG4-CH2COOH

    PROTAC Linker Others
    HOOCCH2O-PEG4-CH2COOH, compound 5, is a symmetric PEG linker, used for the synthesis of the first class of Homo-PROTAC.
  • HY-N4091
    Tinnevellin glucoside

    Others Others
    Tinnevellin glucoside, a naphthalene glycoside, isolated from Cassia senna leaves and pods.
  • HY-B0594
    Iohexol

    Autophagy Mitophagy Others
    Iohexol is a contrast agent.
  • HY-N7055
    Trierucin

    Others Others
    Trierucin is a trierucic acid triglyceride from the seed oil.
  • HY-B1009
    Ethylenediaminetetraacetic acid trisodium salt

    EDTA trisodium salt; Trisodium EDTA

    Ferroptosis Others
    Ethylenediaminetetraacetic acid trisodium salt (EDTA trisodium salt) is used to bind metal ions in the practice of chelation therapy, for treating mercury and lead poisoning, used in a similar manner to remove excess iron from the body, for treating the complication of repeated blood transfusions, as would be applied to treat thalassaemia.
  • HY-B0906
    Bucetin

    3-Hydroxy-p-butyrophenetidide

    Others Others
    Bucetin (3-Hydroxy-p-butyrophenetidide) is an analgesic and antipyretic compound.
  • HY-N2048
    2,2':5',2''-Terthiophene

    α-​Terthiophene; α-Terthienyl; Trithiophene

    Others Others
    2,2':5',2''-Terthiophene (α-Terthiophene) is an oligomer of the heterocycle thiophene. 2,2':5',2''-Terthiophene has been employed as building block for the organic semi-conductor polythiophene.
  • HY-B1410
    Ioversol

    MP-328

    Others Others
    Ioversol is a nonionic iodinated contrast agent.
  • HY-N0668
    Rubusoside

    Others Others
    Rubusoside is a natural sweetener and a solubilizing agent with antiangiogenic and antiallergic properties.
  • HY-Y0079
    D-Phenylalanine

    Endogenous Metabolite Others
    D-Phenylalanine is the synthetic dextro isomer of phenylalanine. D-Phenylalanine inhibits biofilm development of Pseudoalteromonas sp. SC2014.
  • HY-N4096
    Tsugaric acid A

    Others Others
    Tsugaric acid A can significantly inhibit superoxide anion formation. Tsugaric acid A also protects human keratinocytes against damage induced by ultraviolet B (UV B) light. Tsugaric acid A can protect keratinocytes from photodamage.
  • HY-N5038
    Mauritianin

    Topoisomerase Others
    Mauritianin is a kaempferol glycoside isolated from the flowers and leaves of Acalypha indica. Mauritianin is a topoisomerase I inhibitor.
  • HY-N4222
    Acetyl Perisesaccharide C

    Others Others
    Acetyl Perisesaccharide C is an oligosaccharide, which is isolated from the root barks of Periploca sepium.
  • HY-B0744
    Eflornithine

    DFMO; MDL71782; RMI71782; α-difluoromethylornithine

    Others Others
    Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.
  • HY-13019
    BI605906

    IKK Others
    BI605906 is a novel IKKβ inhibitor with an IC50 value of 380 nM when assayed at 0.1 mM ATP.
  • HY-103708
    Nezukone

    C2-deoxyhinokitiol; 4-Isopropyltropone

    Others Others
    Nezukone is a derivative of hinokitiol. Hinokitiol can restore iron transports, however, Nezukone cannot bind or transport iron.
  • HY-N6981
    Methyl Glycyrrhizate

    Others Others
    Methyl Glycyrrhizate, derived from Glycyrrhiza uralensis Fisch., is the ester of methyl alcohol and Glycyrrhizic Acid.
  • HY-B1268
    Docusate Sodium

    Dioctyl sulfosuccinate sodium salt

    HSV Others
    Docusate Sodium is a laxative used to treat constipation, for constipation due to the use of opiates it maybe used with a stimulant laxative, can be taken by mouth or rectally.
  • HY-17527
    Cloxyfonac

    Others Others
    Cloxyfonac is a plant growth regulator and a chemical transformation product; Pesticide agent.
  • HY-N5047
    Orientin-2''-O-p-trans-coumarate

    Others Others
    Orientin-2''-O-p-trans-coumarate is a flavonoid found in Trigonella foenum-graecum, with potent antioxidant activity.
  • HY-112634
    SIRT5 inhibitor 1

    Sirtuin Others
    SIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM.
  • HY-N7024
    Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside

    Others Others
    Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside is from the fresh leaves of Psidium Guajava L..
  • HY-117279
    (S)-Metolachor

    Others Others
    (S)-Metolachor, a derivative of aniline, is a major pesticide in use.
  • HY-N2156
    Paeonolide

    Others Others
    Paeonolide is a plant glycoside that contains a non-reducing end α-l-arabinopyranoside and is found in the roots of the widespread plant genus Paeonia.
  • HY-D0843
    N-Ethylmaleimide

    NEM

    Cathepsin Others
    N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria.
  • HY-N1927
    Menisdaurin

    Others Others
    Menisdaurin is a cyanogenetic glucoside isolated from Flueggea virosa.
  • HY-41461
    5-Amino-3H-imidazole-4-Carboxamide

    5-Aminoimidazole-4-carboxamide; AICA

    Endogenous Metabolite Others
    5-Amino-3H-imidazole-4-Carboxamide (AICA) is an important precursor for the synthesis of purines in general and of the nucleobases adenine and guanine in particular.
  • HY-N2548
    Turkesterone

    Others Others
    Turkesterone, isolated from Ajuga turkestanica, is a potent ecdysteroid. Turkesterone acts as an ecdysteroid receptor (EcR) agonist in some insect systems.
  • HY-112618A
    Thalidomide-O-amido-C6-NH2 (TFA)

    Cereblon Ligand-Linker Conjugates 11 (TFA); E3 Ligase Ligand-Linker Conjugates 25 (TFA)

    E3 Ligase Ligand-Linker Conjugate Others
    Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
  • HY-N1973
    Sennoside D

    Others Others
    Sennoside D is an anthraquinone glycoside, found in leaves and pods of Senna (Cassia angustifolia).
  • HY-12778S
    N-Demethyl Ivabradine D6 Hydrochloride

    Others Others
    N-Demethyl Ivabradine D6 Hcl salt is the deuterium labeled N-Demethyl Ivabradine, which is a metabolite of Ivabradine.
  • HY-102023
    GNF351

    Aryl Hydrocarbon Receptor Others
    GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes.
  • HY-N0391
    L-Citrulline

    Endogenous Metabolite Others
    L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.
  • HY-B1247
    Protoporphyrin IX

    Endogenous Metabolite Others
    Protoporphyrin IX is the final intermediate in the heme biosynthetic pathway.
  • HY-119417
    Chloramben

    3-Amino-2,5-dichlorobenzoic acid

    Others Others
    Chloramben (3-Amino-2,5-dichlorobenzoic acid) is a pre-emergence herbicide used to control the seedlings of annual grasses and broadleaf weeds.
  • HY-W016077
    Glycyl-L-leucine

    Others Others
    Glycyl-l-leucine is a dipeptide that can be a common substrate for glycyl-leucine dipeptidase.
  • HY-B0027
    Valnemulin Hydrochloride

    Bacterial Others
    Valnemulin hydrochloride is a pleuromutilin antibiotic which inhibits protein synthesis in bacteria by binding the peptidyl transferase enzyme in the 50s ribosomal subunit.
  • HY-N4295
    Bacopaside V

    Others Others
    Bacopaside V is a bioactive triterpenoid glycoside of Bacopa monniera, a herb having confirmed nervine tonic activity.
  • HY-N0859
    Schisanhenol

    Schizanhenol; Gomisin-K3

    Others Others
    Schisanhenol is a natural compound solated from Schisandra rubriflora; UGT2B7 UDP-glucuronosyltransferases inhibitor.
  • HY-N6899
    Crocetine dimethyl ester

    Dimethylcrocetin

    Others Others
    Crocetine dimethyl ester (Dimethylcrocetin) is found in the stigmas of saffron (Crocus sativus L.), and has antioxidant activity.
  • HY-113110A
    Cysteinylglycine TFA

    Endogenous Metabolite Others
    Cysteinylglycine TFA is an endogenous metabolite and used in disease diagnosis.
  • HY-N0209
    Cantharidin

    Others Others
    Cantharidin, a natural toxin isolated from beetles in the families Meloidae and Oedemeridae, has been reported to be toxic to some pests, including the diamondback moth.
  • HY-N4220
    Cistanoside F

    Others Others
    Cistanoside F is a phenylethanoid glycosid isolated from Cistanche deserticola, with antioxidative effect.
  • HY-N6085
    N-​Caffeoylputrescine,​(E)​-

    Others Others
    N-​Caffeoylputrescine,​(E)​- is a caffeic acid amide found in the tobacco plants (Nicotiana tabacum L.).
  • HY-16735
    Avoralstat

    BCX4161

    Others Others
    Avoralstat is an oral plasma kallikrein (PKK) inhibitor, used for the treatment of hereditary angioedema.
  • HY-N5030
    8-Hydroxy-3,5,6,7,3',4'-hexamethoxyflavone

    Others Others
    8-Hydroxy-3,5,6,7,3',4'-hexamethoxyflavone is a polymethoxyflavone (PMF) isolated from pericarpium citri reticulatae.
  • HY-B0936
    Roxarsone

    Others Others
    Roxarsone is an organoarsenic compound that is widely used in poultry production as a feed additive to increase weight gain and improve feed efficiency, and as a coccidiostat.
  • HY-B1306
    4-Aminohippuric acid

    p-Aminohippuric acid

    Endogenous Metabolite Others
    4-Aminohippuric acid is a diagnostic agent, useful in medical tests involving the kidney, used in the measurement of renal plasma flow.
  • HY-Y0030
    3-Hydroxypicolinic acid

    Picolinic acid, 3-hydroxy- (6CI,7CI,8CI); 2-Carboxy-3-hydroxypyridine

    Endogenous Metabolite Others
    3-Hydroxypicolinic acid is a picolinic acid derivative, and belongs to the pyridine family.
  • HY-W011602
    Triethyl citrate

    Others Others
    Triethyl citrate is an ester of citric acid. Triethyl citrate can be used as a plasticizer for cellulosic plastic-based nanocomposites.
  • HY-N7056
    4'-Hydroxychalcone

    Others Others
    4'-Hydroxychalcone, a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria.
  • HY-90005S
    Etravirine D4

    TMC-125 D4; R-165335 D4

    Reverse Transcriptase HIV Others
    Etravirine D4 is the deuterium labeled Etravirine. Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.
  • HY-113130
    Eicosadienoic acid

    Endogenous Metabolite Others
    Eicosadienoic acid is a rare, naturally occurring n-6 polyunsaturated fatty acid found mainly in animal tissues.
  • HY-W032915
    5-Phenylvaleric acid

    5-Phenylpentanoic acid

    Endogenous Metabolite Others
    5-Phenylvaleric acid (5-Phenylpentanoic acid) is a pentanoic acid of bacterial origin, occasionally found in human biofluids.
  • HY-N6916
    Siraitic Acid B

    Others Others
    Siraitic Acid B is a cucurbitane triterpenoid isolated from the root of S. grosvenori .
  • HY-113092
    Propionylcarnitine

    Endogenous Metabolite Others
    Propionylcarnitine is a propionyl ester of L-carnitine.
  • HY-17520
    Penthiopyrad

    MTF-753

    Bacterial Others
    Penthiopyrad(MTF-753) is a carboxamide fungicide used to control a broad spectrum of diseases on large variety of corps; inhibits fungal respiration by binding to mitochondrial respiratory complex II.
  • HY-16929
    Latrunculin A

    LAT-A

    Arp2/3 Complex Others
    Latrunculin A (LAT-A) is a toxin isolated from the red sea sponge Latrunculia magnifica, binds to actin monomers, inhibits polymerization of actin, with Kds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively.
  • HY-113413
    Imidazoleacetic acid

    Imidazolyl-4-acetic acid

    Endogenous Metabolite Others
    Imidazoleacetic acid is an endogenous ligand that stimulates imidazole receptors.
  • HY-108630
    U-73343

    Phospholipase Others
    U-73343, an inhibitor of PLC (putative phospholipase C)-dependent processes, is an analog of U-73122 and can be used as a negative control.
  • HY-112066B
    (-)-SHIN1

    (-)-RZ-2994

    Others Others
    (-)-SHIN1 ((-)-RZ-2994) is an inactive (−) enantiomer of SHIN1.
  • HY-111587
    Ifenprodil glucuronide

    Others Others
    Ifenprodil glucuronide is a derivative of Ifenprodil. Ifenprodil is a vasodilator and an inhibitor of platelet aggregation, and Ifenprodil glucuronide has no effect on platelet aggregation and arterial contraction.
  • HY-18658A
    Siremadlin R Enantiomer

    NVP-HDM201 R Enantiomer; HDM201 R Enantiomer

    Others Others
    Siremadlin R Enantiomer (NVP-HDM201 R Enantiomer) is the R enantiomer of Siremadlin. Siremadlin is a potent and highly specific MDM-2/p53 inhibitor.
  • HY-N6639
    3-O-Acetyl-20-Hydroxyecdysone

    Others Others
    3-O-Acetyl-20-Hydroxyecdysone is an steroid isolated from the roots of Cyanotis arachnoidea C.B.Clark.
  • HY-N1955
    Protostemotinine

    Others Others
    Protostemotinine is an alkaloid isolated from the roots and rhizomes of Stemona sessilifolia.
  • HY-111809
    N6-Ethyladenosine

    Adenosine Receptor Others
    N6-Ethyladenosine is an adenosine derivative, acts as a Adenosine receptor agonist, with Kis of 4.9 and 4.7 nM for hA1AR and hA3AR, respectively.
  • HY-N4293
    1,2,3,7-Tetramethoxyxanthone

    Others Others
    1,2,3,7-Tetramethoxyxanthone is a xanthone isolated from Polygala tenuifolia.
  • HY-N1386
    2-Methoxycinnamic acid

    Others Others
    2-Methoxycinnamic acid is a noncompetitive inhibitor of tyrosinase.
  • HY-115365
    (3β,20E)-24-Norchola-5,20(22)-diene-3,23-diol

    Others Others
    (3β,20E)-24-Norchola-5,20(22)-diene-3,23-diol is a steroid-based allylic alcohol.
  • HY-113239
    Hydroxycotinine

    Endogenous Metabolite Others
    Hydroxycotinine is the main nicotine metabolite detected in smokers urine.
  • HY-17564
    2'-Deoxycytidine hydrochloride

    2'-Deoxycytidine monohydrochloride; Deoxycytidine hydrochloride; NSC 83251

    Others Others
    2'-Deoxycytidine hydrochloride is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose.
  • HY-U00090
    N-Methylmoranoline

    MOR 14; N-Methyl-1-deoxynojirimycin; N-Methylmoranolin

    Glucosidase Others
    N-Methylmoranoline (MOR 14) is an α-glucosidase inhibitor.
  • HY-12769
    Mebeverine acid

    Mebeverine metabolite Mebeverine acid

    Drug Metabolite Others
    Mebeverine acid is a metabolite of Mebeverine, which is a musculotropic antispasmodic drug.
  • HY-W012241
    Dodecanedioic acid

    Endogenous Metabolite Others
    Dodecanedioic acid (C12) is a dicarboxylic acid which is a water-soluble substance with a metabolic pathway intermediate to those of lipids and carbohydrates.
  • HY-N1979
    4'-Methoxypuerarin

    4'-O-Methylpuerarin

    Others Others
    4'-Methoxypuerarin (4'-O-Methylpuerarin), an isoflavone diglycoside, is isolated from Pueraria lobata.
  • HY-W016814
    (Z)-Aconitic acid

    cis-Aconitic acid

    Others Others
    (Z)-Aconitic acid (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.
  • HY-W010040
    4-​Hydroxyphenylpyruvic acid

    Endogenous Metabolite Others
    4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine.
  • HY-B2087
    Glycerol phenylbutyrate

    HPN-100

    Others Others
    Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand, with a pKi of 8.02.
  • HY-N6791
    KT5823

    PKA PKC Apoptosis Others
    KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an Ki value of 0.23 μM, it also inhibits PKA and PKC with Ki values of 10 μM and 4 μM, respectively. KT5823 is a staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na +/I - symporter) NIS expression, and iodide uptake in thyroid cells. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation.
  • HY-P0069
    D-JNKI-1

    AM-111; XG-102

    JNK Others
    D-JNKI-1 (AM-111) is a highly potent and cell-permeable peptide inhibitor of JNK.
  • HY-N0839
    Quillaic acid

    Quillaja sapogenin

    Others Others
    Quillaic acid(Quillaja sapogenin) is the major aglycone of the widely studied saponins of the Chilean indigenous tree Quillaja saponaria Mol; can elicit dose-dependent antinociceptive effects in two murine thermal models.
  • HY-W004262
    Methyl nonadecanoate

    Others Others
    Methyl nonadecanoate may be used as an internal standard to determine fatty acid methyl ester (FAME) content of biodiesel.
  • HY-N6744
    Chaetoglobosin A

    Apoptosis Others
    Chaetoglobosin A, the active principle within the extract of Penicillium aquamarinium, is a member of the cytochalasan family. Chaetoglobosin A preferentially induces apoptosis. Chaetoglobosin A targets filamentous actin in CLL cells and thereby induces cell-cycle arrest and inhibits membrane ruffling and cell migration.
  • HY-N7093
    Furaneol

    Others Others
    Furaneol is mainly isolated from American grape (Vitis labrusca) and its hybrid grape. Furaneol is an important aroma compound in fruits and contribute to the strawberry-like note in some wines.
  • HY-107284
    Officinalisinin I

    Others Others
    Officinalisinin I is a steroidal saponin, isolated from Anemarrhena asphodeloides.
  • HY-113135
    5-Methylcytidine

    Endogenous Metabolite Others
    5-Methylcytidine is a pyrimidine nucleoside detected in multiple biofluids.
  • HY-N4258
    Panasenoside

    Glucosidase Others
    Panasenoside is a flavonoid isolated from Lilium pumilum D. C. Panasenoside exhibits α-glucosidase inhibitory activity.
  • HY-12749AS
    Midodrine D6 hydrochloride

    Others Others
    Midodrine D6 hydrochloride is deuterium labeled Midodrine, which is a vasopressor/antihypotensive agent.
  • HY-10167A
    Tecalcet Hydrochloride

    R-568 (hydrochloride)

    CaSR Others
    Tecalcet Hydrochloride (R 568 Hydrochloride), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca 2+.
  • HY-N3962
    Glycyrrhisoflavone

    Glucosidase Others
    Glycyrrhisoflavone, an active prenylflavonoid, mainly derived from the extract of the roots of Glycyrrhiza uralensis Fisch.. Glycyrrhisoflavone inhibits α-glucosidase.
  • HY-W012926
    5,6-Dihydrouracil

    Endogenous Metabolite Others
    5,6-Dihydrouracil is an intermediate breakdown product of uracil.
  • HY-N4133
    Ciwujianoside A1

    Others Others
    Ciwujianoside A1 is isolated from the Eleutherococcus senticosus leaf.
  • HY-N4172
    Tectorigenin 7-​O-​Xylosyl Glucoside

    Others Others
    Tectorigenin 7-​O-​Xylosyl Glucoside is a glycosidic isoflavone isolated from Pueraria thomsonii flower.
  • HY-135588
    Raloxifene 6,4'-Bis-β-D-glucuronide

    Others Others
    Raloxifene 6,4'-Bis-β-D-glucuronide (compound IV) is a metabolite of Raloxifene. Raloxifene is a selective estrogen receptor antagonist for the prevention of osteoporosis.
  • HY-15559A
    Hoechst 33342 trihydrochloride

    bisBenzimide H 33342 trihydrochloride; HOE 33342 trihydrochloride

    Autophagy Others
    Hoechst 33342 trihydrochloride is a membrane permeant blue fluorescent DNA stain.
  • HY-N4265
    Vinaginsenoside R4

    Others Others
    Vinaginsenoside R4, isolated from the leaves of hydroponic Panax ginseng. It has an inhibitory effect on melanin biosynthesis without any cytotoxic effects on the melan-a cells, and enhances the depigmentation on the zebrafish.
  • HY-N3637
    Cotoin

    Others Others
    Cotoin is a natural product isolated from the stem bark of Garcinia virgate.
  • HY-12523
    Peptide M

    Others Others
    Peptide M is a 50 aa synthetic peptide derived from a streptococcal M protein containing an additional C-terminal cysteine residue.
  • HY-N0894
    Octahydrocurcumin

    Hexahydrobisdemethoxycurcumin

    Reactive Oxygen Species Others
    Octahydrocurcumin is a hydrogenated derivatives of curcumin; metabolite of curcumin.
  • HY-17504BS
    Rosuvastatin D3 Sodium

    HMG-CoA Reductase (HMGCR) Autophagy Others
    Rosuvastatin D3 Sodium is deuterium labeled Rosuvastatin, which is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM.
  • HY-N4296
    Isosakuranin

    Others Others
    Isosakuranin is a natural product derived from the fruits of Paliurus ramosissimus.
  • HY-N2274
    23-Hydroxylongispinogenin

    12-Oleanene-3β,16β,23,28-tetrol; 3β,16β-12-Oleanene-3, 16,23,28-tetrol

    Others Others
    23-Hydroxylongispinogenin (12-Oleanene-3β,16β,23,28-tetrol) is extracted from Lysimachia heterogenea Klatt. Lysimachia heterogenea Klatt is a perennial herb, which is used as a folk medicine in subduing swelling and detoxicating in China. The effective fraction LH-1 of L. heterogene has antitumor activity.
  • HY-76633
    Dimethyl 4-hydroxyisophthalate

    Others Others
    Dimethyl 4-hydroxyisophthalate is a methyl salicylate analogue.
  • HY-101981
    Uridine 5'-monophosphate

    5'-​Uridylic acid

    Endogenous Metabolite Others
    Uridine 5'-monophosphate (5'-​Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
  • HY-19563
    A-893

    Histone Methyltransferase Others
    A-893 is a cell-active inhibitor of Methyltransferase SMYD2, with an IC50 of 2.8 nM.
  • HY-N5049
    Alcesefoliside

    Others Others
    Alcesefoliside is a flavonoid isolated from Nitraria sibirica Pall, with antioxidant activity.
  • HY-P0297
    Protease-Activated Receptor-4

    Protease-Activated Receptor (PAR) Others
    Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4).
  • HY-113098
    2-Oxovaleric acid

    Endogenous Metabolite Others
    2-Oxovaleric acid is a keto acid that is found in human blood.
  • HY-W013579
    (S)-(+)-Carvone

    D-​Carvone

    Others Others
    (S)-(+)-Carvone (D Carvone) is a naturally occuring conmpound found in several food items and can be used in flavouring foods.
  • HY-G0006
    Omeprazole metabolite Omeprazole sulfide

    Ufiprazole; Omeprazole sulfide

    Drug Metabolite Others
    Omeprazole metabolite Omeprazole sulfide (Ufiprazole) is a metabolite of Omeprazole, which is a proton pump inhibitor.
  • HY-W002105
    2,5-Furandicarboxylic acid

    Endogenous Metabolite Others
    2,5-Furandicarboxylic acid is a biomass-derived diacid that can be used to make polymers including polyethylene furandicarboxylate (PEF).
  • HY-N6682
    Cytochalasin D

    Zygosporin A; NSC 209835

    Arp2/3 Complex Others
    Cytochalasin D (Zygosporin A; NSC 209835) is a potent and cell-permeable inhibitor of actin polymerization derived from fungus, inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D (Zygosporin A; NSC 209835) also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells.
  • HY-W040189
    Imazaquin

    Others Others
    Imazaquin is an imidazolinone herbicide which inhibits acetohydroxy acid synthase (AHAS). Imazaquin displays high mobility in soils.
  • HY-15830
    25,26-Dihydroxyvitamin D3

    25,26-Dihydroxycholecalciferol

    VD/VDR Endogenous Metabolite Others
    25,26-Dihydroxyvitamin D3(25,26-dihydroxycholecalciferol) is a metabolite of vitamin D3 with intestinal calcium transport activity.
  • HY-100414
    Soraprazan

    BYK61359

    Proton Pump Others
    Soraprazan is a reversible, and fast-acting inhibitor of gastric H +/K + ATPase.
  • HY-B1384
    Retinyl (palmitate)

    Vitamin A palmitate; Retinol palmitate

    Endogenous Metabolite Others
    Retinyl palmitate is an ester of Retinol and is the major form of vitamin A found in the epidermis. Retinyl palmitate has been widely used in pharmaceutical and cosmetic formulations.
  • HY-D0184
    2'-Deoxycytidine

    Deoxycytidine; Cytosine deoxyriboside; Deoxyribose cytidine

    Endogenous Metabolite Others
    2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu).
  • HY-N2606
    Bernardioside A

    Others Others
    Bernardioside A is a triterpenoid saponin isolated from Bellis bernardii.
  • HY-101176
    2-Iodomelatonin

    Melatonin Receptor Others
    2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1  over MT2. 2-iodomelatonin can be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.
  • HY-B1259
    6-Acetamidohexanoic acid

    Acexamic Acid; 6-Acetamidocaproic acid

    Others Others
    6-Acetamidohexanoic acid is a pharmaceutical intermediate
  • HY-N0308
    Octyl acetate

    Others Others
    Octyl acetate is one of major components of essential oils in the vittae, or oil tubes, of the wild parsnip (Pastinaca sativa). Octyl acetate has antioxidant activity.
  • HY-W013636
    2-Ketoglutaric acid

    Alpha-Ketoglutaric acid

    Tyrosinase Endogenous Metabolite Others
    2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM).
  • HY-101203A
    GJ103 sodium salt

    Others Others
    GJ103 sodium salt is an active analog of the read-through compound GJ072.
  • HY-N0563
    Alizarin

    Others Others
    Alizarin is a natural dye extracted from the roots of madder plant and has been widely used as a pigment in textile fabrics and paintings.
  • HY-113427
    trans-Vaccenic acid

    Endogenous Metabolite Others
    trans-Vaccenic acid is a precursor for the synthesis of saturated fatty acid in the rumen and of conjugated linoleic acid (CLA) at the tissue level.
  • HY-N0696
    Sipeimine

    Imperialine

    Others Others
    Sipeimine is a natural product isolated from Fritillaria ussuriensis.
  • HY-100486
    BTTAA

    Others Others
    BTTAA is a Cu(I)-stabilizing ligand, whch performs potently with ubiquitin Glu18AzF.
  • HY-17373S1
    Posaconazole-D4

    SCH 56592-D4

    Fungal Others
    Posaconazole-D4 is a deuterium-labeled form of Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
  • HY-111444
    Auxinole

    Others Others
    Auxinole is a potent auxin antagonist of TIR1/AFB receptors, binding TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex and so inhibits auxin-responsive gene expression.
  • HY-N6996
    Methyl Eugenol

    Others Others
    Methyl Eugenol, a phenylpropanoid chemical in leaves, fruits, stems, and/or roots, may be released when that corresponding part of a plant is damaged as a result of feeding by an herbivore. Methyl Eugenol is used for male annihilation of the oriental fruit fly.
  • HY-112134A
    (R)-CSN5i-3

    Others Others
    (R)-CSN5i-3 is the (R)-enantiomer of CSN5i-3. CSN5i-3 is a potent, selective and orally available inhibitor of CSN5.
  • HY-103194
    KH7

    Others Others
    KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP inhibitor.
  • HY-16926
    CK-666

    Arp2/3 Complex Others
    CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex, and binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation.
  • HY-117541
    Glycyl-glutamine

    Glycyl-L-glutamine

    Others Others
    Glycyl-glutamine (Glycyl-L-glutamine), as a enzymatic cleavage product of β-endorphin, is apparently an endogenous antagonist of beta-endorphin(1-31) in several systems. Glycyl-glutamine (Glycyl-L-glutamine) is an activate and stable glutamine-containing neuropeptide over glutamine (Gln).
  • HY-B1461
    Deoxyarbutin

    Tyrosinase Others
    Deoxyarbutin is a new effective lighten ingredient, can effectively inhibit tyrosinase activity and melanin synthesis to get significant and lasting lightening effect.
  • HY-100217
    D,L-3-Indolylglycine

    α-Amino-1H-indole-3-acetic acid

    Others Others
    D,L-3-Indolylglycine is an unnatural amino acid that is very similar to Tryptophan, with the indole moiety directly attached to the α-position.
  • HY-W040329
    2'-Deoxyadenosine

    Endogenous Metabolite Others
    2'-Deoxyadenosine is a nucleoside adenosine derivative, pairing with deoxythymidine (T) in double-stranded DNA.
  • HY-113278
    Leucyl-phenylalanine

    Endogenous Metabolite Others
    Leucyl-phenylalanine belongs to the class of organic compounds known as dipeptides.
  • HY-127090
    Muramyl dipeptide

    MDP

    p38 MAPK ERK JNK Others
    Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide indirectly attenuates osteoclast differentiation through a decreased RANKL/OPG ratio.
  • HY-N0850
    Benzoylhypaconine

    Benzoylhypacoitine

    Others Others
    Benzoylhypaconine is a natural product.
  • HY-N6964
    Quercetin 3-O-β-D-(6''-p-coumaroyl)glucopyranosyl(1→2)-α-L-rhamnopyranoside

    Quercetin-3-O-[2-O-(6-O-p-hydroxyl-E-coumaroyl)-D-glucosyl]-(1→2)-L-rhamnoside

    Others Others
    Quercetin 3-O-β-D-(6''-p-coumaroyl)glucopyranosyl(1→2)-α-L-rhamnopyranoside (Quercetin-3-O-[2-O-(6-O-p-hydroxyl-E-coumaroyl)-D-glucosyl]-(1→2)-L-rhamnoside) is one of the major antioxidants of Ginkgo biloba leaves.
  • HY-135580
    Raloxifene Bismethyl Ether

    Others Others
    Raloxifene Bismethyl Ether is a metabolite of Raloxifene and an estrogen receptor inactive compound on which both hydroxyl groups are absent.
  • HY-N1884
    4',​7-​Di-​O-​methylnaringenin

    Others Others
    4',​7-​Di-​O-​methylnaringenin is a flavonoid found in Renealmia alpinia.
  • HY-13769A
    TPT-260 Dihydrochloride

    NSC55712; TPU-260 Dihydrochloride

    Others Others
    TPT-260 Dihydrochloride (NSC55712) is a thiophene thiourea derivative with molecule weight 260.00 in free base form; There is no formal name yet, we temporally call this molecule as TPT-260.
  • HY-16671
    CFTR(inh)-172

    CFTR Autophagy Others
    CFTR(inh)-172 is a potent and selective blocker of the CFTR chloride channel; reversibly inhibits CFTR short-circuit current in less than 2 minutes with a Ki of 300 nM.
  • HY-N6664
    Gum arabic

    Arabic gum

    Others Others
    Gum Arabic (Arabic gum) is a branched-chain, complex polysaccharide derive from A. Senegal. Gum Arabic is an anti-oxidant, and can protect against experimental hepatic-, renal- and cardiac toxicities. Gum Arabic also can be used in immunohistochemistry.
  • HY-133234
    BMVC-8C3O

    G-quadruplex Others
    BMVC-8C3O is a DNA G-quadruplexe (G4) ligand which can induce topological conversion of non-parallel to parallel forms in human telomeric DNA G4s.
  • HY-Y1781
    1,4-Diaminobutane dihydrochloride

    Endogenous Metabolite Others
    1,4-Diaminobutane dihydrochloride is an endogenous metabolite, acts as an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI) . 1,4-Diaminobutane dihydrochloride is an important source of GABA.
  • HY-103652
    OT antagonist 3 analog

    Others Others
    OT antagonist 3 analog is an analog of OT antagonist 3.
  • HY-N6867
    Ganoderenic acid E

    Others Others
    Ganoderenic acid E is a lanostane-type triterpene isolated from Ganoderma lucidum.
  • HY-17515
    Ipfencarbazone

    Others Others
    Ipfencarbazone is a substance being developed for the control of weeds such as watergrass in rice; herbicide agent.
  • HY-100335
    PCI-33380

    Btk Others
    PCI-33380 is an irreversible Bruton's Tyrosine Kinase (BTK) inhibitor (fluorescent probe).
  • HY-P1401
    Protein Kinase C 19-36

    PKC Others
    Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM. Protein Kinase C (19-36) markedly attenuated vascular hyperproliferation and hypertrophy as well as glucose-induced suppression of natriuretic peptide receptor response.
  • HY-I0727
    Sofosbuvir impurity E

    HCV Others
    Sofosbuvir impurity E is the less active impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
  • HY-G0023
    Niraparib metabolite M1

    Niraparib carboxylic acid metabolite M1; M1 metabolite of niraparib

    Drug Metabolite Others
    Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.
  • HY-113123
    LysoPC(14:0/0:0)

    Endogenous Metabolite Others
    LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site.
  • HY-12821
    AEBSF hydrochloride

    Influenza Virus Thrombin Others
    AEBSF hydrochloride is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.
  • HY-107829
    3-Aminopropionitrile fumarate (2:1)

    Di-β-aminopropionitrile fumarate; β-Aminopropionitrile fumarate; β-Ammoniumpropionitrile hemifumarate

    Others Others
    3-Aminopropionitrile fumarate (2:1) is a lathyrogen which inhibits crosslinking of collagen.
  • HY-N4311
    2,3,4,5-Tetracaffeoyl-D-Glucaric acid

    Others Others
    2,3,4,5-Tetracaffeoyl-D-Glucaric acid is a caffeoyl-D-glucaric acid derivative isolated from the Genus Gnaphalium.
  • HY-N1939
    Icariside I

    Icarisid I

    Others Others
    Icariside I is a metabolite of Icarlin, which could regulate bone remodeling and is recognized as an effective agent for the treatment of osteoporosis.
  • HY-N0442
    5-O-Methylvisammioside

    4'-O-β-D-Glucosyl-5-O-methylvisamminol

    Others Others
    5-O-Methylvisammioside is a natural product isolated from Saposhnikovia Divaricata.
  • HY-N2605
    Camelliaside B

    Others Others
    Camelliaside B is a flavonoid from the methanol extract of tea (Camellia oleifera) seed pomace.
  • HY-113013
    Hydroxypyruvic acid

    Endogenous Metabolite Others
    Hydroxypyruvic acid is an intermediate in the metabolism of Glycine, serine and threonine. It is a substrate for Serine--pyruvate aminotransferase and Glyoxylate reductase/hydroxypyruvate reductase.
  • HY-10388A
    TTA-Q6(isomer)

    Others Others
    TTA-Q6(isomer) is an isomer of TTA-Q6. TTA-Q6 is a selective T-type Ca 2+ channel antagonist.
  • HY-130801
    5-Hydroxy-2'-deoxyuridine

    5-OHdU

    Endogenous Metabolite Others
    5-Hydroxy-2'-deoxyuridine (5-OHdU) is a major stable oxidation product of 2'-Deoxycytidine. 5-Hydroxy-2'-deoxyuridine can be incorporated into DNA in vitro by DNA polymerase.
  • HY-17642
    Omidenepag

    Prostaglandin Receptor Others
    Omidenepag,a pharmacologically active form of Omidenepag Isopropyl, is a selective, non-prostanoid EP2 receptor agonist, with an EC50 of 1.1 nM. Omidenepag shows binding affinities (IC50) 10 nM for h-EP2.
  • HY-113047
    5,6-Dihydrouridine

    Endogenous Metabolite Others
    5,6-Dihydrouridine is a modified base found in conserved positions in the D-loop of tRNA in Bacteria, Eukaryota, and some Archaea.
  • HY-133113
    7-Desmethyl-agomelatine

    Others Others
    7-Desmethyl-agomelatine is a metabolite of Agomelatine. Agomelatineis a potent agonist at melatonin receptors (MT1 and MT2), and also is an antagonist of 5-HT2C.
  • HY-N2324
    Paulownin

    (+)-Paulownin

    Others Others
    Paulownin, a component of wood of Paulownia tomentosa Steud, is a constituent of medicinal plants.
  • HY-13636B
    Fulvestrant R enantiomer

    ICI 182780 R enantiomer; ZD 9238 R enantiomer; ZM 182780 R enantiomer

    Others Others
    Fulvestrant R enantiomer (ICI 182780 R enantiomer; ZD 9238 R enantiomer; ZM 182780 R enantiomer) is the less active R enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM.
  • HY-122524
    7-Methylguanosine

    Nucleoside Antimetabolite/Analog Others
    7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor with IC50 value of 87.8 ± 7.5 µM.
  • HY-N2834
    Akuammiline

    Others Others
    Akuammiline, is isolated from isolated from the seeds of Picralima klaineana.
  • HY-14538S
    Haloperidol D4

    Dopamine Receptor Others
    Haloperidol D4 is deuterium labeled haloperidol, and the latter is a potent dopamine D2 receptor antagonist.
  • HY-N0869
    Ingenol-5,20-acetonide

    Others Others
    Ingenol-5,20-acetonide is an intermediate from ingenol for synthesis of ingenoids; improved stability compared to ingenol.
  • HY-D0987
    Stains-All

    Others Others
    Stains-All is a cationic carbocyanine dye.
  • HY-15435
    CHAPS

    Others Others
    CHAPS is a zwitterionic nondenaturing detergent for solubilizing membrane proteins.
  • HY-B0515B
    Ibandronate Sodium

    Others Others
    Ibandronate Sodium is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.
  • HY-W011151
    trans-Zeatinriboside

    Others Others
    trans-Zeatinriboside is a type of cytokinin precursor, acts as a major long-distance signalling form in xylem vessels, regulates leaf size and meristem activity-related traits.
  • HY-B0109
    Dorzolamide

    L671152; MK507

    Carbonic Anhydrase Others
    Dorzolamide(L671152; MK507) is an anti-glaucoma agent, which is a carbonic anhydrase inhibitor.
  • HY-B0803S
    Lumefantrine D18

    Benflumetol D18

    Parasite Others
    Lumefantrine D18 is the deuterium labeled Lumefantrine, which is an antimalarial drug.
  • HY-107820
    Ethylvanillin acetate

    Others Others
    Ethyl vanillin acetate is acectate form of ethyl vanillin. Ethyl vanillin acetate is a flavorant used in chocolate or candy.
  • HY-117389
    Homocarbonyltopsentin

    PK4C9

    Others Others
    Homocarbonyltopsentin (PK4C9) is a small-molecule TSL2-binding compound, binds to pentaloop conformations of TSL2 and promotes a shift to triloop conformations that display enhanced SMN2 exon 7 (E7) splicing with EC50 value of 16 μM.
  • HY-N2124
    Parishin B

    Others Others
    Parishin B, a parishin derivative isolated from Gastrodia elata, may have antioxidant property.
  • HY-B1146
    Denatonium benzoate

    THS-839

    Others Others
    Denatonium benzoate (THS-839) is the most bitter chemical compound known,used as aversive agents (bitterants) to prevent inappropriate ingestion.
  • HY-W020215
    Tricarballylic acid

    Others Others
    Tricarballylic acid, a conjugate acid of a tricarballylate, is a competitive inhibitor of the enzyme aconitate hydratase (aconitase; EC 4.2.1.3) with a Ki value of 0.52 mM.
  • HY-113071A
    Mevalonic acid lithium salt

    Endogenous Metabolite Others
    Mevalonic acid lithium salt, a precursor in the mevalonate pathway, is essential for cell growth and proliferation.
  • HY-113227
    Oxoadipic acid

    Endogenous Metabolite Others
    Oxoadipic acid is a key metabolite of the essential amino acids tryptophan and lysine.
  • HY-W009749B
    D,L-Cystathionine dihydrochloride

    Others Others
    D,L-Cystathionine dihydrochloride is an intermediate in the synthesis of cysteine that is produced from homocysteine and serine by the action of cystathionine-β-synthase (CBS). DL-Cystathionine contains a carbon-sulfide bond of cystathionine (βC-S) linkage.
  • HY-100332
    CP 375

    Others Others
    CP 375 is a Fe 3+ chelating agent, with a log K1 value of 14.50.
  • HY-N2201
    Pseudoginsenoside RT1

    Others Others
    Pseudoginsenoside RT1, isolated from the fruit of Randia siamensis, exhibits acute ichthyotoxic activity.
  • HY-B0266
    Gadodiamide hydrate

    Others Others
    Gadodiamide hydrate is a gadolinium-based contrast agent used in MR imaging procedures to assist in the visualization of blood vessels.
  • HY-112670
    Exo1

    Others Others
    Exo1 is a chemical inhibitor of the exocytic pathway.
  • HY-B1991
    Terbutryn

    Others Others
    Terbutryn is a selective herbicide and a triazine compound. It is absorbed by the roots and foliage and acts as an inhibitor of photosynthesis.
  • HY-123785
    ORM-10962

    Na+/Ca2+ Exchanger Others
    ORM-10962 is a potent, highly selective sodium-calcium exchanger (NCX) inhibitor, with IC50 values of 67 and 55 nM for the reverse and forward mode inhibition, respectively.
  • HY-N0445
    2-Hydroxy-4-methoxybenzaldehyde

    Tyrosinase Others
    2-Hydroxy-4-methoxybenzaldehyde, a chemical compound and an isomer of Vanillin, could be used to synthesis Urolithin M7. 2-hydroxy-4-methoxybenzaldehyde is a potent tyrosinase inhibitor from three East African medicinal plants, Mondia whitei, Rhus vulgaris Meikle, and Sclerocarya caffra Sond.
  • HY-100177
    L-Threonine derivative-1

    Others Others
    L-Threonine derivative-1 is a acetylsalicylic-L-threonine ester extracted from patent US 20060287244 A1.
  • HY-113236
    p-Synephrine

    Endogenous Metabolite Others
    p-Synephrine is an organic compound, found in multiple biofluids, such as urine and blood.
  • HY-12751S
    Trimethobenzamide D6

    Others Others
    Trimethobenzamide D6 is deuterium labeled Trimethobenzamide. Trimethobenzamide is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.
  • HY-N1450
    Aristolochic acid C

    Phospholipase Others
    Aristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid is a phospholipase A2 (PLA2) inhibitor, which disrupts cortical microtubule arrays and root growth in Arabidopsis.
  • HY-100061A
    2-(Dimethylamino)acetaldehyde hydrochloride

    Others Others
    2-(Dimethylamino)acetaldehyde hydrochloride can be used to synthesis Muscarine analogues.
  • HY-12993A
    RSV604 racemate

    RSV Others
    RSV604 racemate is a racemic mixture, shows less potency against strains of respiratory syncytial virus (RSV) than the S-isomer.
  • HY-N6259
    5,​7,​3'-​Trihydroxy-​6,​4',​5'-​trimethoxyflavone

    Others Others
    5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone is a methylated flavones from Artemisia frigida.
  • HY-B0964A
    Riboflavine phosphate

    Riboflavine 5'-phosphate

    Endogenous Metabolite Others
    Riboflavine phosphate is a very effective NAD +-recycling agent.
  • HY-W008772
    4-Hydroxymephenytoin

    Others Others
    4-Hydroxymephenytoin is a metabolism of an antiepileptic drug mephenytoin, which is used as a CYP2C19 substrate.
  • HY-114626
    L-Lysine thioctate

    Others Others
    L-Lysine thioctate is a substrate of lipoamidase.
  • HY-N3433
    Kaempferol 3-O-arabinoside

    Others Others
    Kaempferol 3-O-arabinoside is an antioxidant flavonoids isolated from ethyl acetate fraction (EAF) obtained from the leaves of Nectandra hihua. Kaempferol 3-O-arabinoside has good antioxidant capacity.
  • HY-13995A
    Sevelamer hydrochloride

    FXR Autophagy Others
    Sevelamer hydrochloride is a phosphate binding drug used to treat hyperphosphatemia in patients with chronic kidney disease; consists of polyallylamine that is crosslinked with epichlorohydrin.
  • HY-112171
    γ-L-Glutamyl-L-alanine

    Others Others
    γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is a proteolytic breakdown product of larger proteins.
  • HY-P0028
    Phalloidin

    Others Others
    Phalloidin is a mushroom-derived toxin which can be used to label F-actin of the cytoskeleton with fluorochrome (λex=495 nm, λem=520 nm).
  • HY-N2397
    9''-Methyl salvianolate B

    Others Others
    9''-Methyl salvianolate B is a phenolic compound isolated from Radix Salvia miltiorrhizae.
  • HY-N0387
    Rhynchophylline

    NF-κB Others
    Rhyncholphylline, an alkaloid isolated from Uncaria, shows potent inhibition of lipopolysaccharide (LPS)-induced NO production in rat primary microglial cells.
  • HY-N2522
    Carboxyatractyloside dipotassium

    Gummiferin dipotassium

    Others Others
    Carboxyatractyloside dipotassium is a toxic natural product, acts as an inhibitor of ADP/ATP carrier, inhibits mitochondrial ADP/ATP transport.
  • HY-N2188
    Beta-Acetoxyisovalerylshikonin

    Others Others
    Beta-Acetoxyisovalerylshikonin is a naphthoquinone derivative isolated from Arnebia euchroma.
  • HY-N4213
    Anemarrhenasaponin I

    Others Others
    Anemarrhenasaponin I, a traditional Chinese medicine, is isolated from Anemarrhena asphodeloides Bunge.
  • HY-B0897
    Bisoctrizole

    Others Others
    Bisoctrizole is a broad-spectrum ultraviolet radiation absorber, absorbing UVB as well as UVA rays; also reflects and scatters UV.
  • HY-100168
    BAPTA

    Reactive Oxygen Species Others
    BAPTA is a calcium chelator. BAPTA suppresses intracellular reactive oxygen species (ROS) levels.
  • HY-N2438
    Methylophiopogonanone B

    Ras Others
    Methylophiopogonanone B, homoisoflavonoid, is extracted from the root of Ophiopogon japonicas, shows high antioxidant ability. Methylophiopogonanone B increases GTP-Rho and acts via the Rho signaling pathway, inducing cell morphological change via actin cytoskeletal reorganization, including dendrite retraction and stress fiber formation.
  • HY-N0935
    Ligustrazine hydrochloride

    Chuanxiongzine hydrochloride; Tetramethylpyrazine hydrochloride

    Others Others
    Ligustrazine (hydrochloride) is a natural product.
  • HY-113036
    Epipregnanolone

    Endogenous Metabolite Others
    Epipregnanolone is an endogenous neurosteroid that has hypnotic, and sedative properties.
  • HY-B0750B
    Dolasetron Mesylate hydrate

    MDL-73147EF (hydrate)

    5-HT Receptor Others
    Dolasetron Mesylate hydrate (MDL-73147EF hydrate) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.
  • HY-124422
    Pentacosanoic acid

    Endogenous Metabolite Others
    Pentacosanoic acid is a 25-carbon long-chain saturated fatty acid. Pentacosanoic is a conjugate acid of a pentacosanoate.
  • HY-17021A
    Esomeprazole magnesium salt

    Proton Pump Others
    Esomeprazole magnesium salt is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.
  • HY-19531
    9-Azido-Neu5DAz

    Others Others
    9-Azido-Neu5DAz is a non-natural bifunctional carbohydrates as imaging agent.
  • HY-N3201
    Neoprzewaquinone A

    Others Others
    Neoprzewaquinone A is isolated from the roots of Salvia miltiorrhiza.
  • HY-B1934
    Methyl stearate

    Others Others
    Methyl stearate, isolated from Rheum palmatum L. is a compopent of of soybean and rapeseed biodiesels.
  • HY-101547
    TRPC6-IN-1

    TRP Channel Others
    TRPC6-IN-1 is a Transient Receptor Potential Canonical 6 Channel (TRPC6) inhibitor, with an EC50 of 4.66 μM.
  • HY-B0989
    Carzenide

    4-Sulfamoylbenzoic acid

    Others Others
    Carzenide is an organic synthesis intermediate, for synthetic drug.
  • HY-N4297
    Baicalin methyl ester

    Others Others
    Baicalin methyl ester is a constituent of the roots of S. baicalmsis.
  • HY-133013
    GLPG-3221

    CFTR Others
    GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis.
  • HY-N2212
    Arctigenin 4'-O-β-gentiobioside

    Others Others
    Arctigenin 4'-O-β-gentiobioside is a natural compound isolated from Arctigenin.
  • HY-42210
    1,3-Diaminopropane

    Endogenous Metabolite Others
    1,3-Diaminopropane, a three carbon diamine, is an ornithine decarboxylase inhibitor.
  • HY-12688
    Succinyl phosphonate

    Others Others
    Succinyl phosphonate is an inhibitor of the α-ketoglutarate dehydrogenase.
  • HY-N2289
    2''-O-Rhamnosylicariside II

    Others Others
    2''-O-Rhamnosylicariside II is a flavonoid glycoside compound and might be beneficial for improving postmenopausal osteoporosis.
  • HY-B0892
    Benzyl alcohol

    Benzenemethanol

    Others Others
    Benzyl alcohol is an aromatic alcohol; a colorless liquid with a mild pleasant aromatic odor.
  • HY-B0496
    PMSF

    Phenylmethylsulfonyl fluoride; Benzylsulfonyl fluoride

    Cathepsin Others
    PMSF is an irreversible serine/cysteine protease inhibitor commonly used in the preparation of cell lysates.
  • HY-N6815
    Isomogroside V

    Others Others
    Isomogroside V is a sweetener, which extracted from Siraitia grosvenorii (Swingle).
  • HY-N0881
    Desacetylcinobufagin

    Deacetylcinobufagin

    Others Others
    Desacetylcinobufagin is a natural compound used for microbial transformation.
  • HY-N0257
    Epimedin A

    Others Others
    Epimedin A is a natural compound extracted from Herba Epimedii.
  • HY-112295
    AzKTB

    Others Others
    AzKTB is a capture reagent which bears a short trypsin-cleavable peptide sequence between the azide module and the TAMRA/PEG-biotin labels.
  • HY-W009749
    L-Cystathionine

    Endogenous Metabolite Others
    L-Cystathionine is a key nonprotein amino acid related to metabolic conditions.
  • HY-14946
    Amifampridine

    3,4-Diaminopyridine

    Others Others
    Amifampridine (3,4-Diaminopyridine) is a drug, predominantly in the treatment of a number of rare muscle diseases.
  • HY-N7100
    Ethyl chrysanthemate

    Others Others
    Ethyl chrysanthemate is an allelochemical compound used as an attractant.
  • HY-N0568
    Madecassoside

    Asiaticoside A

    Apoptosis Others
    Madecassoside is a pentacyclic triterpene isolated from Centella asitica (L.
  • HY-120215
    KT203

    MAGL Others
    KT203 is a potent and selective inhibitor of α/β-hydrolase domain containing 6 (ABHD6), with an IC50 of 0.31 nM in Neuro2A cells.
  • HY-113268
    Biotin sulfone

    Endogenous Metabolite Others
    Biotin sulfone is first isolated as a natural metabolite of biotin.
  • HY-W010608
    2-Methyltetrahydrofuran-3-one

    Others Others
    2-Methyltetrahydrofuran-3-one is one of the volatile constituents of roasted coffee.
  • HY-113437
    1,2-Dipalmitoyl-sn-glycerol 3-phosphate

    Endogenous Metabolite Others
    1,2-Dipalmitoyl-sn-glycerol 3-phosphate (compound 3-F7) is a phosphatidic acid and a human endogenous metabolite.
  • HY-100511
    Benzophenonetetracarboxylic acid

    3,3',4,4'-Benzophenonetetracarboxylic acid

    Others Others
    Benzophenonetetracarboxylic acid (3,3',4,4'-Benzophenonetetracarboxylic acid) is particularly useful in the preparation of high performance polyimides and also useful as curing agents for epoxy resins.
  • HY-W050026
    Phenylacetylglutamine

    NSC 203800; Phenylacetyl-L-glutamine

    Endogenous Metabolite Others
    Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation.
  • HY-128876
    P300/CBP-IN-3

    Histone Acetyltransferase Others
    P300/CBP-IN-3, a p300/CBP histone acetyltransferase inhibitor, Compound 6, is sourced from patent WO 2019049061 A1.
  • HY-N2275
    21-​O-​Tigloylgymnemagenin

    Others Others
    21-​O-​Tigloylgymnemagenin (Compound 7) is a acylated triterpenes isolated from Gymnema sylvestre.
  • HY-N7079A
    Sodium erythorbate

    D-Araboascorbic acid sodium; D-​Isoascorbic acid sodium

    Others Others
    Sodium erythorbate (D-Isoascorbic acid sodium), produced from sugars derived from different sources, such as beets, sugar cane, and corn, is a food additive used predominantly in meats, poultry, and soft drinks.
  • HY-N1750
    3-(2,4-Dihydroxyphenyl)propanoic acid

    Tyrosinase Others
    3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) is a potent and competitive tyrosinase inhibitor, inhibits L-Tyrosine and DL-DOPA with an IC50 and a Ki of 3.02 μM and 11.5 μM, respectively.
  • HY-12771
    O-desmethyl Mebeverine acid

    Mebeverine metabolite O-desmethyl Mebeverine acid

    Drug Metabolite Others
    O-desmethyl Mebeverine acid is a metabolite of Mebeverine, which is a musculotropic antispasmodic drug.
  • HY-128430
    Farnesyl acetate

    Others Others
    Farnesyl acetate is a sesquiterpene isolated from the leaves of Amomum gagnepainii. Farnesyl acetate has significant toxicity against red palm weevil larvae with a LD50 of 7867 ppm.
  • HY-135383
    (3S,5S)-Pitavastatin calcium

    Others Others
    (3S,5S)-Pitavastatin cacium is the 3-epimer of Pitavastatin. Pitavastatin is a potent HMG-CoA reductase inhibitor.
  • HY-N6906
    Oleuroside

    Others Others
    Oleuroside is a phenolic secoiridoid in olive. Oleuroside can protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing.
  • HY-113357
    m-Coumaric acid

    Endogenous Metabolite Others
    m-Coumaric acid is a polyphenol metabolite from caffeic acid, formed by the gut microflora and the amount in human biofluids is diet-dependant.
  • HY-N0311
    Emodin-8-glucoside

    Others Others
    Emodin-8-glucoside is an anthraquinone derivative isolated from Aloe vera, binds to minor groove of DNA.
  • HY-N0870
    Ingenol-5,20-acetonide-3-O-angelate

    Ingenol 5,20-acetonide 3-angelate; Ingenol 3-angelate 5,20-acetonide

    Others Others
    Ingenol-5,20-acetonide-3-O-angelate is a natural compound.
  • HY-N0899
    Wilforine

    Others Others
    Wilforine is a sesquiterpene pyridine alkaloid; important bioactive compound in T. wilfordii plants, and is effective in treating idiopathic pulmonary fibrosis.
  • HY-N0739
    Betaine hydrochloride

    Betaine chloride

    Others Others
    Betaine hydrochloride is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns.
  • HY-126073
    DFP00173

    Others Others
    DFP00173 is a potent and selective aquaporin-3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with an IC50 of ∼0.1-0.4 μM. DFP00173 is selective for AQP3 over the homologous AQP isoforms AQP7 and AQP9.
  • HY-W015060
    2-(2-Methylbenzamido)acetic acid

    Endogenous Metabolite Others
    2-(2-Methylbenzamido)acetic acid is a metabolite detected in urine.
  • HY-F0004
    β-Nicotinamide mononucleotide

    β-NM; NMN

    Endogenous Metabolite Others
    β-nicotinamide mononucleotide (β-NM) is an intermediate in NAD+ biosynthesis produced from nicotinamide (NAM) and phosphoribosyl pyrophosphate (PRPP) by nicotinamide phosphoribosyl transferase enzyme with no toxicity.
  • HY-113353
    Nicotinuric acid

    Endogenous Metabolite Others
    Nicotinuric acid is an acyl glycine. Nicotinuric acid is a metabolite of nicotinic acid.
  • HY-114460
    SHP2 IN-1

    Phosphatase Others
    SHP2 IN-1 (compound 13) is an allergic inhibitor of SHP2 (PTPN11), with an IC50 of 3 nM.
  • HY-N0611
    alpha-Boswellic acid

    α-Boswellic acid

    Others Others
    alpha-Boswellic acid is a natural product.
  • HY-128838A
    (rel)-PROTAC ERRα Degrader-1

    Others Others
    (rel)-PROTAC ERRα Degrader-1 is a relative configuration of PROTAC ERRα Degrader-1. PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an estrogen-related receptor alpha (ERRa) degrader.
  • HY-76082
    L-Pyroglutamic acid

    Endogenous Metabolite Others
    L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.
  • HY-109111
    Azelaprag

    Others Others
    Azelaprag (Example 263.0) is an apelin receptor agonist drug candidate.
  • HY-15677A
    INT-777 R-enantiomer

    S-EMCA R enantiomer

    GPCR19 Others
    INT-777 (R-enantiomer) is the R-enantiomer of INT-777, with EC50 of 4.79 μM for TGR5, and less potent than INT-777.
  • HY-N0097
    Guanosine

    DL-Guanosine; Vernine

    Endogenous Metabolite Others
    Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond.
  • HY-N0879
    Pseudobufarenogin

    ψ-Bufarenogin

    Others Others
    Pseudobufarenogin is a natural compound extracted from toad species with unknown details.
  • HY-G0011S
    Netupitant N-oxide D6

    Drug Metabolite Others
    Netupitant N-oxide D6 is the deuterium labeled Netupitant N-oxide, which is a metabolite of Netupitant.
  • HY-111806
    3,7,4'-Trihydroxyflavone

    5-Deoxykampferol

    DNA/RNA Synthesis Others
    3,7,4'-Trihydroxyflavone, isolated from Rhus javanica var. roxburghiana, is a flavonoid with DNA strand-scission activity.
  • HY-50674A
    INCB3344 R-isomer

    Others Others
    INCB3344 R-isomer is the R-isomer of INCB3344. INCB3344 is a potent CCR2 antagonist.
  • HY-128597
    BRD-IN-3

    Epigenetic Reader Domain Others
    BRD-IN-3 ((R,R)-36n) is a highly potent PCAF bromodomain (BRD) inhibitor, with an IC50 of 7 nM. BRD-IN-3 also exhibits activity against GCN5 and FALZ.
  • HY-N3011
    Iridin

    Others Others
    Iridin is an isoflavone isolated from Iris milesii.
  • HY-75766S
    Methylnaltrexone D3 Bromide

    Opioid Receptor Others
    Methylnaltrexone D3 Bromide is the deuterium labeled Methylnaltrexone Bromide. Methylnaltrexone Bromide is a peripheral-acting opioid receptor antagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation.
  • HY-N4188
    N-Benzyloctadecanamide

    N-Benzylstearamide

    Others Others
    N-Benzyloctadecanamide (N-Benzylstearamide) is a macamide, a distinct class of secondary metabolites in Lepidium meyenii Walp. (Maca).
  • HY-103035
    BIO-32546

    Phosphodiesterase (PDE) Others
    BIO-32546 (example 12b, S-isomer) is an autotaxin (ATX) modulator, extracted from the patent US20170158687A1.
  • HY-107368
    Sulcotrione

    Reactive Oxygen Species Others
    Sulcotrione is a β-triketone herbicide which can inhibit hydroxyphenylpyruvate dioxygenase (HPPD).
  • HY-18102
    GLPG0492

    Androgen Receptor Others
    GLPG0492 is a novel selective androgen receptor modulator; exhibited anabolic activity on muscle, strongly dissociated from the androgenic activity on prostate after oral dosing.
  • HY-W014993
    1,3-Dimethyluric acid

    Endogenous Metabolite Others
    1,3-Dimethyluric acid is a product of theophylline metabolism in man. 1,3-Dimethyluric acid is one of the purine components in urinary calculi.
  • HY-N6879
    DiosMetin 7-O-β-D-Glucuronide

    Others Others
    DiosMetin 7-O-β-D-Glucuronide is an antioxidant constituent in the fruits of Luffa cylindrical.
  • HY-101970
    Deoxypseudouridine

    Nucleoside Antimetabolite/Analog Others
    Deoxypseudouridine is a nucleotide analog.
  • HY-W017524
    2-Methylpentanedioic acid

    Endogenous Metabolite Others
    2-Methylpentanedioic acid is a metabolite of succinic acid, a citric acid cycle intermediate.
  • HY-B0959
    Chloramine-T

    Others Others
    Chloramine-T is a titrimetric reagent, and an oxidizing agent.
  • HY-114202
    delta-Valerobetaine

    Endogenous Metabolite Others
    delta-Valerobetaine is a precursor of trimethylamine N-oxide (TMAO).
  • HY-W020044
    DL-alpha-Tocopherol

    DL-α-Tocopherol

    Ferroptosis Others
    DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB.
  • HY-12751A
    Trimethobenzamide hydrochloride

    Ro 2-9578

    Dopamine Receptor Others
    Trimethobenzamide hydrochloride is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.
  • HY-N6070
    Ricinoleic acid

    Others Others
    Ricinoleic acid, from castor (Ricinus communis) seed oil, is a high-value hydroxy fatty acid with broad industrial applications. Ricinoleic acid is an attractive feedstock for the production of high-performance lubricants, cosmetics, polymers, surfactants, and coatings.
  • HY-Y1093
    Ethyl acetoacetate

    Ethyl acetylacetate

    Others Others
    Ethyl acetoacetate (Ethyl acetylacetate) is an ester widely used as an intermediate in the synthesis of many varieties of compounds. Ethyl acetoacetate is an inhibitor of bacterial biofilm.
  • HY-113673
    A-935142

    Potassium Channel Others
    A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. A-935142 enhances hERG current in a complex manner by facilitation of activation, reduction of inactivation, and slowing of deactivation, and abbreviates atrial and ventricular repolarization.
  • HY-135404
    Anhydrosimvastatin

    Dehydro simvastatin

    Others Others
    Anhydrosimvastatin (Impurity C) is an impurity of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase.
  • HY-N1430
    Oxyresveratrol

    trans-Oxyresveratrol

    Tyrosinase HSV Autophagy Others
    Oxyresveratrol is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia.
  • HY-18900
    Nec-4

    RIP kinase Others
    Nec-4, a tricyclic derivative, is a potent receptor interacting protein 1 (RIP1) inhibitor, with an IC50 of 2.6 μM, Ki of 0.46 μM.
  • HY-N0086
    N6-Methyladenosine

    6-Methyladenosine; N-Methyladenosine

    Others Others
    N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes.
  • HY-W016813
    trans-Aconitic acid

    Endogenous Metabolite Others
    trans-Aconitic acid is present in normal human urine, and it has been suggested that is present in larger amounts with Reye's syndrome and organic aciduria. trans-Aconitic acid is a substrate of enzyme trans-aconitate 2-methyltransferase.
  • HY-103006
    NAI-N3

    Others Others
    NAI-N3 is a novel RNA acylation reagent that enables RNA purification.
  • HY-109513
    Ioxilan

    Others Others
    Ioxilan is a low-osmolar, nonionic and tri-iodinated diagnostic contrast agent. Ioxilan is also an X-ray contrast agent for excretory urography and contrast enhanced computed tomographic (CECT) imaging of the head and body. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs.
  • HY-B1368
    Fenclonine

    4-Chloro-DL-phenylalanine; PCPA; CP-10188

    Tryptophan Hydroxylase Others
    Fenclonine is a pharmaceutical intermediate.
  • HY-N0897
    Corylifol A

    Corylifol-A; Corylinin

    STAT Others
    Corylifol A inhibits IL-6-induced STAT3 activation and phosphorylation, with an IC50 of 0.81 μM.
  • HY-N0860
    Schisantherin E

    Schizantherin-E

    Others Others
    Schisantherin E is a natural compound isolated from the active fraction of the fruits of Schisandra sphenanthera Rehd. et Wils.
  • HY-114380
    Radioprotectin-1

    LPL Receptor Others
    Radioprotectin-1 is a potent and specific nonlipid agonist of lysophosphatidic acid receptor 2 (LPA2), with an EC50 value of 25 nM for murine LPA2 subtype.
  • HY-N5104
    Clemaphenol A

    Others Others
    Clemaphenol A is a chemical constituent of the flower of Fritillaria pallidiflora.
  • HY-135386
    5β-​Dutasteride

    Drug Metabolite Others
    5β-Dutasteride is the S configuration of Dutasteride. 5β-Dutasteride is a potent inhibitor of both 5 alpha-reductase isozymes.
  • HY-N2204
    Swertiajaponin

    Tyrosinase Others
    Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC50 of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity.
  • HY-B0934
    Ethylparaben

    Ethyl parahydroxybenzoate; Ethyl 4-hydroxybenzoate

    Bacterial Others
    Ethylparaben is the ethyl ester of p-hydroxybenzoic acid, used as an antifungal preservative.
  • HY-N2170
    Acetylshengmanol Arabinoside

    Others Others
    Acetylshengmanol Arabinoside is isolated from Cimicifugae rhizoma.
  • HY-N5027
    Oxyberberin

    Berlambine; 8-Oxoberberine; Ketoberberine

    Others Others
    Berlambine is a natural alkaloid isolated from many plants.
  • HY-N6029
    Dehydroevodiamine hydrochloride

    Others Others
    Dehydroevodiamine hydrochloride is isolated from the leaves of Evodia rutaecarpa.
  • HY-112165
    PRMT5-IN-2

    Histone Methyltransferase Others
    PRMT5-IN-2 is a rotein arginine methyltransferase 5 (PRMT5) inhibitor extracted from patent WO2018130840A1, compound 3.
  • HY-113286
    4-Guanidinobutanoic acid

    Endogenous Metabolite Others
    4-Guanidinobutanoic acid is a normal metabolite present in low concentrations.
  • HY-B1720
    Ubiquinol

    Ubiquinol-10; CoQH2-10

    Endogenous Metabolite Others
    Ubiquinol (Ubiquinol-10) is a reduced form of coenzyme Q10 (CoQ10). Ubiquinol is a potent antioxidant that has the capacity to protect Vitamin E, and also helps to regenerate depleted vitamin E and Vitamin C. Ubiquinol is both lipophilic and hydrophilic and acts as transmembrane factor preventing lipid peroxidation and propagation by transferring electrons to ROS.
  • HY-N7078
    Spiculisporic acid

    Others Others
    Spiculisporic acid is a γ-butenolide isolated from the cultue of Aspergillus sp .
  • HY-N2504
    Ginsenoside Rk2

    Others Others
    Ginsenoside Rk2 is a dammarane glycoside isolated from the processed ginseng (SG; Sun Ginseng).
  • HY-N0681
    D-Pantothenic acid hemicalcium salt

    Calcium pantothenate; Calcium D-pantothenate; Vitamin B5 calcium salt

    Apoptosis Endogenous Metabolite Others
    D-Pantothenic acid hemicalcium salt (Vitamin B5 calcium salt), a vitamin, can reduce the patulin content of the apple juice.
  • HY-102054
    Acetylhydrolase-IN-1

    Others Others
    Acetylhydrolase-IN-1 is a 1-Alkyl-2-acetylglycerophosphocholine esterase (Alkylacetyl-GPC: acetylhydrolase) inhibtor.
  • HY-B0553
    Methazolamide

    L584601

    Carbonic Anhydrase Others
    Methazolamide is a carbonic anhydrase inhibitor used to treat glaucoma.
  • HY-18594
    NSC-41589

    Others Others
    NSC-41589 is an N-[2-(methylsulfanyl) phenyl]acetamide.
  • HY-W006395
    1-Methylcytosine

    Nucleoside Antimetabolite/Analog Others
    1-Methylcytosine is a methylated form of the DNA base cytosine and used as a nucleobase of hachimoji DNA, in which it pairs with Isoguanine.
  • HY-N1958
    Syringaresinol diglucoside

    Syringaresinol-di-O-glucoside

    Others Others
    Syringaresinol diglucoside is a natural compound from bamboo leaves.
  • HY-111639
    2’-O,4’-C-Methyleneuridine

    Nucleoside Antimetabolite/Analog Others
    2’-O,4’-C-Methyleneuridine (Compound 15a) is a bicyclic nucleoside.
  • HY-W007856
    5-Methoxysalicylic acid

    5-MeOSA

    Others Others
    5-Methoxysalicylic acid (5-MeOSA) is a natural compound, used as a useful matrix in the MALDI MS analysis of oligonucleotides when combined with spermine.
  • HY-W004260
    Arachidic acid

    Icosanoic acid

    Endogenous Metabolite Others
    Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue.
  • HY-17533
    Chromafenozide

    ANS118

    Others Others
    Chromafenozide (ANS118) is a lepidopteran insecticide; it is highly effective in controlling various lepidopteran pests.
  • HY-N1881
    4',5-Dihydroxyflavone

    Lipoxygenase Glucosidase Others
    4',5-Dihydroxyflavone is a soybean LOX-1 and yeast α-Glucosidase inhibitor, with an Ki of 102.6 μM for soybean LOX-1 and an IC50 of 66 μM for yeast α-glucosidase. LOX-1 isshort for Lectin-like oxidized low-density lipoprotein receptor-1.
  • HY-50071
    6-Amino-5-nitropyridin-2-one

    Nucleoside Antimetabolite/Analog Others
    6-Amino-5-nitropyridin-2-one is a pyridine base and used as a nucleobase of hachimoji DNA, in which it pairs with 5-aza-7-deazaguanine.
  • HY-N2586
    Tenuifoliside C

    Others Others
    Tenuifoliside C, isolated from polygala tenuifolia willd, significantly inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1.
  • HY-107265
    Lucidenic acid E

    Others Others
    Lucidenic acid E is a terpenoid from Ganoderma lucidum.
  • HY-111389
    FAAH-IN-1

    FAAH Autophagy Others
    FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.
  • HY-18771
    O4I1

    Oct3/4 Others
    O4I1 is as a potent Oct3/4 inducer.
  • HY-B0998
    Dehydrocholate sodium

    Sodium dehydrocholate

    Endogenous Metabolite Others
    Dehydrocholic sodium is a hydrocholeretic, increasing bile output to clear increased bile acid load.
  • HY-40135
    L-Hydroxyproline

    Endogenous Metabolite Others
    L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.
  • HY-N7387
    3-​Oxocholic acid

    Endogenous Metabolite Others
    3-Oxocholic acid is an oxo-bile acid metabolite and also a major degradation product from cholic by C. perfringens in the intestine. 3-Oxocholic acid is steroid acid found predominantly in bile of mammals.
  • HY-119764
    Ikarugamycin

    Others Others
    Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME).
  • HY-113298
    Citraconic acid

    Endogenous Metabolite Others
    Citraconic acid belongs to the class of organic compounds known as methyl-branched fatty acids.
  • HY-135737
    Dicaprylyl carbonate

    Others Others
    Dicaprylyl carbonate, a solid, plant-derived fat, is a dry emollient. Dicaprylyl carbonate has excellent dermatological compatibility and a comprehensive performance profile, such as solubilizing and dispersing ability for sun-care filters.
  • HY-A0080
    Aminohippurate sodium

    Sodium p-aminohippurate; p-Aminohippuric acid sodium salt

    Others Others
    Aminohippurate sodium is a diagnostic agent useful in medical tests involving the kidney used in the measurement of renal plasma flow.
  • HY-N7267
    31-Norlanostenol

    Others Others
    31-Norlanostenol is a triterpenic compound isolated from the latex of Euphorbia officinarum. 31-Norlanostenol can act as efficient insect growth regulator on S. frugiperda and Tenebrio molitor.
  • HY-N6889
    Rebaudioside I

    Others Others
    Rebaudioside I is a natural non-claoric sweetener isolated from S. rebaudiana Morita.
  • HY-N6999
    Soyasaponin Ac

    Others Others
    Soyasaponin Ac is a triterpenoid isolated from the seeds of Glycine max.
  • HY-100759
    JAK2-IN-4

    JAK Others
    JAK2-IN-4 (compound 16h) is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.
  • HY-135405
    4-Acetylsimvastatin

    Others Others
    4-Acetylsimvastatin is an acetylated simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.
  • HY-117226A
    GSK 690 Hydrochloride

    Histone Demethylase Others
    GSK 690 (Hydrochloride) is a reversible inhibitor of lysine specific demethylase 1 (LSD1), with a Kd value of 9 nM and a biochemical IC50 of 37 nM.
  • HY-P0291
    Kemptide Phospho-Ser5

    PKA Others
    Kemptide (Phospho-Ser5) is a phosphate acceptor peptide that serves as a specific substrate for cAMP-dependent protein kinase (PKA).
  • HY-N2941
    Bisandrographolide C

    TRP Channel Others
    Bisandrographolide C is an unusual dimer of ent-labdane diterpenoid isolated and identified from Andrographis paniculata. Bisandrographolide C activates TRPV1 and TRPV3 channels with Kd values of 289 and 341 μM respectively, and protects cardiomyocytes from hypoxia-reoxygenation injury.
  • HY-A0277
    Cyproconazole

    Bacterial Others
    Cyproconazole is a triazole fungicide that is used agriculturally for protection of crops against a wide variety of fungal pathogens.
  • HY-B0590S
    Tetrabenazine D6

    Ro 1-9569 D6

    Monoamine Transporter Others
    Tetrabenazine D6 is the deuterium labeled Tetrabenazine, which is a VMAT-inhibitor used for treatment of hyperkinetic movement disorder.
  • HY-120870
    para-Nitroblebbistatin

    Myosin Others
    para-Nitroblebbistatin is a non-cytotoxic, photostable, fluorescent and specific Myosin II inhibitor, usd in the study of the specific role of myosin II in physiological, developmental, and cell biological studies.
  • HY-N6992
    Dulcoside A

    Others Others
    Dulcoside A is isolated from Stevia rebaudiana, it often advertised as a sweetener.
  • HY-N2245
    Schisandrone

    Others Others
    Schisandrone, a 4-aryltetralone lignan, is isolated from the dried fruits of Schisandra sphenanthera.
  • HY-N2327
    Oleamide

    Endogenous Metabolite Others
    Oleamide is an endogenous fatty acid amide which can be synthesized de novo in the mammalian nervous system, and has been detected in human plasma.
  • HY-N2398
    Rehmapicroside

    Others Others
    Rehmapicroside is an ionone glycoside isolated from rhizomes of Rehmannia glutinosa.
  • HY-B0964
    Riboflavin phosphate sodium

    FMN-Na; Riboflavin 5'-phosphate sodium; Vitamin B2 Phosphate Sodium Salt

    Endogenous Metabolite Others
    Riboflavin phosphate sodium significantly increases in corneal biomechanical stiffness
  • HY-N0449
    Nordihydrocapsaicin

    Others Others
    Nordihydrocapsaicin is a capsaicinoid analog and congener of capsaicin in chili peppers.
  • HY-101953S
    β-Apo-13-carotenone D3

    D'Orenone D3

    Others Others
    β-Apo-13-carotenone D3 is the deuterium labeled β-Apo-13-carotenone. β-Apo-13-carotenone (D'Orenone) is a naturally occurring β-apocarotenoid functioned as an antagonist of RXRα.
  • HY-N2001
    Araloside X

    Others Others
    Araloside X (Congmunoside X) is a triterpenoid saponin isolated from Aralia elata.
  • HY-119706
    Barbadin

    Others Others
    Barbadin is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC50 values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors.
  • HY-N0885
    Telocinobufagin

    Telobufotoxin; Telocinobufogenin

    Others Others
    Telocinobufagin is one of anti-hepatoma constituent in Venenum Bufonis.
  • HY-125849
    Chrysin 7-O-beta-gentiobioside

    Chrysin 7-O-β-gentiobioside

    Others Others
    Chrysin 7-O-beta-gentiobioside (Chrysin 7-O-β-gentiobioside) is the glycosylation product of Chrysin.
  • HY-W008646
    7,8-Dihydro-L-biopterin

    Endogenous Metabolite Others
    7,8-Dihydro-L-biopterin is an oxidation product of tetrahydrobiopterin.
  • HY-128036
    ddATP

    2',3'-Dideoxyadenosine 5'-triphosphate

    DNA/RNA Synthesis Others
    ddATP is a dideoxynucleotide, acts as a chain-elongating inhibitor of DNA polymerase, used for Sanger method for DNA sequencing.
  • HY-N2373
    Palmaturbine

    Others Others
    Palmaturbine is isolated from T. sinensis.
  • HY-N4101
    Styraxlignolide F

    Others Others
    Styraxlignolide F is a natural compoundisolated from Styrax japonica.
  • HY-D0850
    Tartaric acid disodium dihydrate

    Sodium tartrate dibasic dihydrate; Sodium tartrate dihydrate

    Phosphatase Others
    Tartaric acid disodium dihydrate is a Acid phosphatase inhibitor, is a sodium salt used in buffers for molecular biology and cell culture applications.
  • HY-B2013
    Fenoxaprop-P-ethyl

    Others Others
    Fenoxaprop-P-ethyl is a post-emergent phenoxy herbicide of the aryloxyphenoxy propionate group.
  • HY-100638
    RPR132595A

    NPC

    Others Others
    RPR132595A (NPC) is an active metabolite of CPT-11, which is generated by cytochrome P-450 3A4 (CYP3A4) and finally excreted through urine.
  • HY-I0513
    Sofosbuvir impurity N

    HCV Others
    Sofosbuvir impurity N, an diastereoisomer of sofosbuvir, is the impurity of sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.
  • HY-125826
    Heptasaccharide Glc4Xyl3

    Others
    Heptasaccharide Glc4Xyl3, a covalent inhibitor of endo-xyloglucanases, is used for the identification and analysis of diverse xyloglucan-active enzymes in nature.
  • HY-107824
    D-Melibiose

    Endogenous Metabolite Others
    D-Melibiose is a disaccharide which is composed of one galactose and one glucose moiety in an alpha (1-6) glycosidic linkage.
  • HY-B1918
    (+)-Bornyl acetate

    Others Others
    (+)-Bornyl acetate is found in pichtae essential oil (Siberian fir needle oil). (+)-Bornyl acetate has a stronger inhibitory effect on root growth of Arabidopsis seedlings.
  • HY-N6008
    7-O-Methyl morroniside

    Others Others
    7-O-Methyl morroniside is an iridoid glycoside (IG) extracted from Cornus officinalis fructus, used in many traditional Chinese medicines.
  • HY-17584
    Linaclotide

    Guanylate Cyclase Others
    Linaclotide is a potent and selective guanylate cyclase C agonist; developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation.
  • HY-N2002
    Araloside VII

    Congmunoside VII

    Others Others
    Araloside VII (Congmunoside VII) is a saponin isolated from leaves of Aralias elate.
  • HY-114926
    KT185

    MAGL Others
    KT185 is an orally-bioavailable, brain-penetrant and selective ABHD6 inhibitor, with an IC50 0.21 nM in Neuro2A cells.
  • HY-18675
    IQ-R

    Others Others
    IQ-R is a novel hypoxia-sensitive fluorescent probe, consisting of an indolequinone unit and a rhodol fluorophore.
  • HY-N0805A
    Alisol B

    Others Others
    Alisol B is a potentially novel therapeutic compound for bone disorders by targeting the differentiation of osteoclasts as well as their functions.
  • HY-135237
    DB04760 analog 1

    Others Others
    DB04760 analog 1 is an analogue of DB04760.
  • HY-N5135
    Liriopesides B

    Nolinospiroside F

    Others Others
    Liriopesides B (Nolinospiroside F) is a steroidal saponin isolated from Ophiopogon japonicas. Liriopesides B has anti-oxidative and anti-aging effects.
  • HY-12771S1
    O-desmethyl Mebeverine acid D5 hydrochloride

    Others Others
    O-desmethyl Mebeverine acid D5 hydrochloride is the deuterium labeled O-desmethyl Mebeverine acid.
  • HY-N7268
    Solanidiene

    Solanthrene

    Others Others
    Solanidiene (Solanthrene) is isolated from the leaves of S. tuberosum.
  • HY-18761
    Cobalt phthalocyanine

    Cobalt(II) phthalocyanine; Cobaltous phthalocyanine; Phthalocyanine cobalt complex

    Others Others
    Cobalt phthalocyanine is a catalyst of redox reaction, catalyzes aerobic regenerations of aldehydes and ketones from aldoximes and ketoximes has been developed.
  • HY-N0075
    (Rac)-Byakangelicin

    Others Others
    (Rac)-Byakangelicin is a racemate of Byakangelicin mainly isolated from the genus Angelica. Byakangelicin is an aldose-reductase inhibitor with an IC50 value of 6.2 μM.
  • HY-N3002
    α-Arbutin

    4-Hydroxyphenyl α-D-glucopyranoside

    Others Others
    α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is emerging as popular and effective skin whiteners, acting as tyrosinase inhibitor.
  • HY-W016188
    1-Naphthyl acetate

    AChE Others
    1-Naphthyl acetate is an attractive chromogenic substrate for the detection of erythrocyte acetylcholinesterase (AChE) activity. 1-Naphthyl acetate has the potential to detect organophosphorus pesticide (OP) poisoning.
  • HY-128606
    Thiamine diphosphate analog 1

    Others Others
    Thiamine diphosphate analog 1 is an analog of Thiamine diphosphate. Thiamine diphosphate is the active form of vitamin B1. Thiamine diphosphate a universal cofactor involved in pivotal cellular pathways.
  • HY-12770S
    Mebeverine alcohol D5

    Others Others
    Mebeverine alcohol D5 is the deuterium labeled Mebeverine alcohol, which is a metabolite of Mebeverine.
  • HY-N0873
    Sagittatoside A

    Icariin-A

    Others Others
    Sagittatoside A is a natural compound isolated from traditional Chinese herb Yinyanghuo (Herba Epimdii).
  • HY-N2256
    (-​)​-​Salutaridine

    Others Others
    (-)-Salutaridine (Salutaridine) is an alkaloid isolated from the stems of Sinomenium acutum.
  • HY-17525
    Bethoxazin

    Bacterial Others
    Bethoxazin(Bethoguard) is a new broad spectrum industrial microbicide with applications in material and coating preservation.
  • HY-121546
    ALLO-1

    Autophagy Others
    ALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif.
  • HY-12872B
    Nazartinib S-enantiomer

    EGF816 (S-enantiomer)

    Others Others
    Nazartinib S-enantiomer (EGF816 S-enantiomer) is the less active S-enantiomer of Nazartinib. Nazartinib (EGF816) is an EGFR inhibitor.
  • HY-128352
    SMYD3-IN-1

    Histone Methyltransferase Others
    SMYD3-IN-1 (compound 29) is an irreversible and selective inhibitor of SMYD3 (SET and MYND domain containing 3), with an IC50 of 11.7 nM.
  • HY-111531
    DMTr-LNA-5MeU-3-CED-phosphoramidite

    Nucleoside Antimetabolite/Analog Others
    DMTr-LNA-5MeU-3-CED-phosphoramidite is a nucleoside derivative.
  • HY-N2555
    Tilianin

    Others Others
    Tilianin is a flavonoid glycoside of Dragocephalum moldavicum L..
  • HY-N3003
    Darutigenol

    Others Others
    Darutigenol is an ent-pimarane-type diterpenoid isolated from Siegesbecikia orientalis L..
  • HY-16268
    Kartogenin

    KGN

    TGF-beta/Smad Others
    Kartogenin is an inducer of differentiation of human mesenchymal stem cells into chondrocytes.
  • HY-N6817
    Isoagarotetrol

    Others Others
    Isoagarotetrol is a natural product isolated from agalwood.
  • HY-N2175
    Cixiophiopogon A

    Others Others
    Cixiophiopogon A, a steroidal glycoside, obtained from the tuberous roots of Ophiopogon japonicus (Liliaceae).
  • HY-126487
    H-Arg-Lys-OH

    Endogenous Metabolite Others
    H-Arg-Lys-OH is a dipeptide formed from L-arginyl and L-lysine residues.
  • HY-113291
    5'-Deoxyadenosine

    Endogenous Metabolite Others
    5'-Deoxyadenosine is an oxidized nucleoside found in the urine of normal subjects.
  • HY-N2031
    Parishin

    Others Others
    Parishin is a phenolic glucoside isolated from Gastrodia elata. Parishin exhibits antiaging effects and extends the lifespan of yeast via regulation of Sir2/Uth1/TOR signaling pathway.
  • HY-N0354
    Anthraquinone

    Virus Protease Others
    Anthraquinone is used as a precursor for dye formation.
  • HY-101409
    O-Acetylserine

    O-Acetyl-L-serine

    Endogenous Metabolite Others
    O-Acetylserine (O-Acetyl-L-serine) is an intermediate in the biosynthesis of the amino acid cysteine in bacteria and plants.
  • HY-N0847
    Micheliolide

    Others Others
    Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs).
  • HY-16615
    SIRT-IN-1

    Sirtuin Others
    SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively.
  • HY-112104
    Meta-Topolin

    m-Topolin

    Others Others
    Meta-Topolin (m-Topolin) is a highly active aromatic cytokinin.
  • HY-W010791
    Adenosine 5'-diphosphate sodium salt

    Endogenous Metabolite Others
    Adenosine 5'-diphosphate (ADP) sodium salt is a nucleoside diphosphate, which is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate sodium salt induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors.
  • HY-12773AS
    5-Hydroxy Propafenone D5 Hydrochloride

    GPV-129 D5 Hydrochloride; Lu 40-545 D5

    Others Others
    5-Hydroxy Propafenone D5 Hcl is the deuterium labeled 5-Hydroxy Propafenone.
  • HY-16916
    NS1643

    Potassium Channel Autophagy Others
    NS1643 is a partial agonist of human ether-a-go-go-related gene (hERG) K(+) channels with an EC50 of 10.5 μM.
  • HY-W010321
    Furfuryl acetate

    Others Others
    Furfuryl acetate can be used in the synthesis of 5-acetoxymethyl-2-vinylfuran and 5-hydroxymethyl-2-vinylfuran.
  • HY-B0244S
    Praziquantel D11

    Parasite Others
    Praziquantel D11 is the deuterium labeled Praziquantel, which is an anthelmintic.
  • HY-G0018
    Norgestimate metabolite Norelgestromin

    17-Deacetyl norgestimate; 17-Deacylnorgestimate

    Drug Metabolite Others
    Norelgestromin is a metabolite of Norgestimate, which is a progestin or synthetic progestogen.
  • HY-W007926
    2-Oxobutanoic acid

    Endogenous Metabolite Others
    2-Oxobutanoic acid is a product in the enzymatic cleavage of cystathionine.
  • HY-B1141
    Eprodisate disodium

    NC-503

    Others Others
    Eprodisate disodium (NC-503) is the orally available disodium salt form of Eprodisate, a negatively charged sulfonated inhibitor of fibrillogenesis, that can be used in the treatment of amyloid A (AA) amyloidosis.
  • HY-N4261
    Dehydronuciferine

    AChE Others
    Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC50 of 25 μg/mL.
  • HY-103082
    CLK1-IN-1

    CDK Others
    CLK1-IN-1 is a potent and selective of Cdc2-like kinase 1 (CLK1) inhibitor, with an IC50 of 2 nM.
  • HY-W012922
    2-Methyl-4-pentenoic Acid

    2-Methylpent-4-enoic acid

    Others Others
    2-Methyl-4-pentenoic Acid is an organic acid.
  • HY-N2285
    Fabiatrin

    Others Others
    Fabiatrin is a natural product isolated from Przewalskia tangutica.
  • HY-109654
    Ensulizole

    Others Others
    Ensulizole is a sulfonated UV absorber and can intense UVB and partial UVA absorption. Ensulizole can damage the DNA through the generation of reactive oxygen species (ROS) upon UV or sunlight irradiation. Ensulizole is a water soluble sunscreen ingredient.
  • HY-N2440
    Gypenoside A

    Others Others
    Gypenoside A is a natural compound isolaated from Gynostemma pentaphyllum Makino.
  • HY-N4173
    8-Oxoepiberberine

    Others Others
    8-Oxoepiberberine is an alkaloid metabolite in the plasma after oral administration of Zuojin formula, a traditional chinese medicine used to treat gastrointestinal disease.
  • HY-15641
    FG-2216

    IOX3; YM311

    HIF/HIF Prolyl-Hydroxylase Others
    FG-2216 (IOX3; YM311) is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo.
  • HY-N7130
    Thioisonicotinamide

    4-Pyridylthioamide

    Others Others
    Thioisonicotinamide (4-Pyridylthioamide) is a synthetic intermediate used for pharmaceutical synthesis.
  • HY-111110
    Olorinab

    APD 371

    Cannabinoid Receptor Others
    Olorinab (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist, with an EC50 of 6.2 nM for hCB2.
  • HY-113061
    Pseudouridine

    Endogenous Metabolite Others
    Pseudouridine, the most abundant modified nucleoside in non-coding RNAs, enhances the function of transfer RNA and ribosomal RNA by stabilizing RNA structure.
  • HY-12515B
    (S)-Nicardipine

    (S)-YC-93 free base

    Others Others
    (S)-Nicardipine ((S)-YC-93 free base) is the less active S enantiomer of Nicardipine. Nicardipine is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine acts as an agent for chronic stable angina and for controlling blood pressure.
  • HY-F0003A
    NADPH (tetracyclohexanamine)

    Ferroptosis Others
    NADPH tetracyclohexanamine is a ubiquitous cofactor and biological reducing agent.
  • HY-108294
    Nonaethylene glycol monododecyl ether

    Nonaoxyethylene monododecyl ether

    Others Others
    Nonaethylene glycol monododecyl ether (Nonaoxyethylene monododecyl ether) is a nonionic surfactant and polyethylene glycol (PEG) detergent that can be used to form initial coalesced O/W emulsion droplets, as well as for protein separation and purification.
  • HY-16670
    Dafadine-A

    Cytochrome P450 Others
    Dafadine-A, an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1).
  • HY-12765S
    Losartan (D4 Carboxylic Acid)

    E-3174 D4; EXP-3174 D4

    Angiotensin Receptor Others
    Losartan D4 Carboxylic Acid is the deuterium labeled Losartan(EXP-3174), which is an angiotensin II receptor antagonist.
  • HY-N5079
    Lotaustralin

    Others Others
    Lotaustralin is a cyanogenic glucoside isolated from Manihot esculenta .
  • HY-112758
    DLin-KC2-DMA

    Others Others
    DLin-KC2-DMA is a cationic/ionizable lipid for siRNA delivery.
  • HY-135801
    Arachidonyl alcohol

    Others Others
    Arachidonyl alcohol is a long-chain primary fatty alcohol. Arachidonyl alcohol is used as a substrate for the production of several ether lipids possessing beneficial functions.
  • HY-B1280
    Nikethamide

    N,N-Diethylnicotinamide

    Others Others
    Nikethamide, one of the respiratory central stimulants, has the potential for respiratory failure treatment.
  • HY-N0788
    Indaconitine

    15-Deoxyaconitine

    Others Others
    Indaconitine is a natural product.
  • HY-113498
    Sphingomyelin

    Endogenous Metabolite Others
    Sphingomyelin is a type of sphingolipid found in animal cell membranes and implicates in the regulation of trans-membrane signaling.
  • HY-112106A
    Diethyl aminoethyl hexanoate citrate

    DA-6 citrate; 2-Diethylaminoethyl hexanoate citrate

    Others Others
    Diethyl aminoethyl hexanoate citrate is a compound that is widely used as a plant growth regulator.
  • HY-112729
    HC-056456

    3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide

    Others Others
    HC-056456 is an effective but not perfectly-selective blocker of CatSper channels. The [Na +]i rise is slowed by HC-056456 (IC50~3 µM).
  • HY-W011704A
    Phosphoenolpyruvic acid tricyclohexylammoniu​m salt

    Others Others
    Phosphoenolpyruvic acid tricyclohexylammoniu​m salt is a glycolysis metabolite with a high-energy phosphate group, penetrates the cell membrane and exhibits cytoprotective and anti-oxidative activity.
  • HY-N0537
    Xylose

    D-(+)-Xylose; (+)-Xylose; Wood sugar

    Endogenous Metabolite Others
    Xylose, a natural product, can be catalyzed into xylulose by xylose isomerase, and it is the key step for anaerobic ethanolic fermentation of xylose.
  • HY-N7082
    D-​Arabinose

    Others Others
    D-Arabinose, a monosaccharide, shows strong growth inhibition against the Caenorhabditis elegans with an IC50 of 7.5 mM.
  • HY-I0301
    D-(+)-Glucono-1,5-lactone

    Gluconic acid lactone

    Endogenous Metabolite Reactive Oxygen Species Others
    D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activity.
  • HY-N4240
    Dihydropalmatine

    Others Others
    Dihydropalmatine is a alkaloid isolated from Berberis aristata.
  • HY-N6715
    Tenuazonic acid

    Others Others
    Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate. Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D1 protein and it is a broad-spectrum and effective photosystem II (PSII) inhibitor.
  • HY-W010098
    Terephthalic acid

    Endogenous Metabolite Others
    Terephthalic acid is one isomer of the three phthalic, a precursor to the polyester PET, used to make clothing and plastic bottles.
  • HY-124540B
    (Rac)-ABT-202 dihydrochloride

    Others Others
    (Rac)-ABT-202 dihydrochloride is a racemate of ABT-202. ABT-202 is an agonistor of nicotinic acetylcholine receptors (nAChRs) and can be used as an analgesic.
  • HY-113080
    N-Acetylornithine

    Endogenous Metabolite Others
    N-Acetylornithine is an intermediate in the enzymatic biosynthesis of the amino acid L-arginine from L-glutamate.
  • HY-P1036
    Compstatin

    Complement System Others
    Compstatin is a 13-residue cyclic peptide and a potent inhibitor of the complement system, and has species specificity.
  • HY-17535
    Methasulfocarb

    Fungal Others
    Methasulfocarb is a fungicide compound.
  • HY-114158
    Pronase E

    Pronase

    Others Others
    Pronase E is a mixture of proteolytic enzymes that is obtained from Streptomyces griseus and could digest protein into individual amino acids.
  • HY-109031
    Dotinurad

    Others Others
    Dotinurad is a potent uricosuric agent, with an IC50 of 3.6 µM for uric acid.
  • HY-109656
    Diethylamino hydroxybenzoyl hexyl benzoate

    DHHB

    Others Others
    Diethylamino hydroxybenzoyl hexyl benzoate is a photostable UV-A absorber.
  • HY-W013636B
    Calcium 2-oxoglutarate

    Tyrosinase Endogenous Metabolite Others
    2-Ketoglutaric acid calcium (Alpha-Ketoglutaric acid calcium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid calcium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid calcium is a reversible inhibitor of tyrosinase (IC50=15 mM).
  • HY-B0744A
    Eflornithine hydrochloride

    DFMO hydrochloride; MDL71782 hydrochloride; RMI71782 hydrochloride; α-difluoromethylornithine hydrochloride

    Others Others
    Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.
  • HY-N4279
    Gentisin

    Others Others
    Gentisin is a natural compound isolated from Gentianae radix (Gentianaceae) with mutagenic activities.
  • HY-Y0084
    3,4,5-Trimethoxybenzoic acid

    Eudesmic acid; Trimethylgallic Acid

    Others Others
    3,4,5-Trimethoxybenzoic acid (Eudesmic acid;Trimethylgallic Acid) is a benzoic acid derivative. A building block in medicine and organic synthesis.
  • HY-W015307
    4-Ethyloctanoic acid

    Others Others
    4-Ethyloctanoic acid is a natural compound first isolated from Saussurea lappa Clarke, widely used as a safe flavoring compound and acts as food additive.
  • HY-B2050
    Trifluralin

    Others Others
    Trifluralin is a commonly used pre-emergence herbicide. Trifluralin is generally applied to the soil to provide control of a variety of annual grass and broadleaf weed species. It inhibits root development by interrupting mitosis, and thus can control weeds as they germinate.
  • HY-B2193
    α-Amylase

    Others Others
    α-Amylase is a hydrolase enzyme that catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose.
  • HY-135297
    Mono-and diglycerides

    Others Others
    Mono-and diglycerides is formed by triglycerides being broken down by pancreatic lipase in the gastrointestinal lumen. Mono-and diglycerides is a food additive used as a nonionic emulsifier and mainly present in food fats.
  • HY-100288
    RP 73163 Racemate

    Others Others
    RP 73163 Racemate is the racemate of RP 73163. RP 73163 is a potent ACAT inhibitor, with cholesterol lowering activity.
  • HY-12766S
    Bupropion morpholinol D6

    Hydroxy Bupropion D6

    Others Others
    Bupropion morpholinol D6 is a useful labeled metabolite of Bupropion.
  • HY-N6609
    Magnocurarine

    Others Others
    Magnocurarine a natural compound isolated from Tiliacora racemosa.
  • HY-135324
    4,4'-Iminodiphenol

    Estrogen Receptor/ERR Others
    4-Propionamidophenol (compound 4a) is an inactive estrogen receptor ligand based on the diphenylamine skeleton.
  • HY-104009A
    GSK2807 Trifluoroacetate

    Histone Methyltransferase Others
    GSK2807 Trifluoroacetate is a potent, selective and SAM-competitive inhibitor of SMYD3, with a Ki of 14 nM and an IC50 of 130 nM.
  • HY-B0575S
    Triamterene D5

    Sodium Channel Others
    Triamterene D5 is deuterium labeled Triamterene, which can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic.
  • HY-B0109A
    Dorzolamide hydrochloride

    L671152 hydrochloride; MK507 hydrochloride

    Carbonic Anhydrase Others
    Dorzolamide hydrochloride (L671152 Hcl; MK507 Hcl) is an anti-glaucoma agent, which is a carbonic anhydrase inhibitor.
  • HY-B0877
    Halcinonide

    SQ-18566

    Smo Others
    Halcinonide (SQ-18566) is a high potency corticosteroid used topically in the treatment of certain skin conditions.
  • HY-113131
    Dihydroxyacetone phosphate

    Endogenous Metabolite Others
    Dihydroxyacetone phosphate is an important intermediate in lipid biosynthesis and in glycolysis. It is a biochemical compound involved in many metabolic pathways, including the Calvin cycle in plants and glycolysis. Dihydroxyacetone phosphate is found to be associated with transaldolase deficiency, which is an inborn error of metabolism.
  • HY-N6808
    Rebaudioside B

    Others Others
    Rebaudioside B is the minor constituent isolated from the leaves of Stevia rebaudiana Bertoni. Rebaudioside B tastes about 150 times sweeter than sucrose .
  • HY-14846A
    Litronesib Racemate

    LY-2523355 Racemate; KF-89617 Racemate

    Kinesin Others
    Litronesib (Racemate) is the racemate of litronesib. Litronesib is a selective, allosteric inhibitor of kinesin Eg5.
  • HY-N6243
    Veratrosine

    Others Others
    Veratramine is a steroidal alkaloid extracted from the roots and rhizomes of Veratrum californicum.
  • HY-A0087
    Octocrylene

    Others Others
    Octocrylene is an organic compound used as an ingredient in sunscreens and cosmetics.
  • HY-N2100
    6'-O-beta-D-Glucosylgentiopicroside

    Others Others
    6'-O-beta-D-Glucosylgentiopicroside is a secoiridoid isolated from the roots of G. straminea. 6'-O-beta-D-Glucosylgentiopicroside strongly suppresses N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation.
  • HY-N7257
    Glucosinalbate

    Others Others
    Glucosinalbate is a natural product isolated from Arabidopsis thaliana.
  • HY-N3460
    Isorhoifolin

    Others Others
    Isorhoifolin is a flavonoid glycoside from periploca nigrescens leaves. Isorhoifolin displays an anti-leakage effect.
  • HY-I1112
    Fmoc-N-Me-Val-OH

    Others Others
    Fmoc-N-Me-Val-OH is a modified peptide.
  • HY-N2626
    Epimedoside A

    Others Others
    Epimedoside A is a flavonoid isolated from the roots of Epimedium wushanense. Epimedoside A exhibits significant antioxidant activity in vitro.
  • HY-12515C
    (R)-Nicardipine

    (R)-YC-93 free base

    Others Others
    (R)-Nicardipine ((R)-YC-93 free base) is the less active R enantiomer of Nicardipine. Nicardipine (YC-93) is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine acts as an agent for chronic stable angina and for controlling blood pressure.
  • HY-117289
    AKOS B018304

    Others Others
    AKOS B018304 is an arylalkylidene derivative, with polar substitution at para-position.
  • HY-78828A
    (S)-Dolaphenine hydrochloride

    Others Others
    (S)-Dolaphenine hydrochloride is a useful componet for compound synthesis.
  • HY-19654B
    (-)-GSK598809

    1S,5R-GSK598809

    Others Others
    (-)-GSK598809 is an isomer of GSK598809. GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist.
  • HY-108539A
    (R)-CE3F4

    Others Others
    (R)-CE3F4 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC50 of 4.2 μM, with 10-fold selectivity for Epac1 over Epac2 (IC50, 44 μM). (R)-CE3F4 is more potent than racemic CE3F4 and (S)-CE3F4.
  • HY-111919
    3-Nitrocoumarin

    Phospholipase Others
    3-Nitrocoumarin (3-NC) is a potent and selective Phospholipase C-γ (PLC-γ) inhibitor.
  • HY-12769S
    Mebeverine acid D5

    Others Others
    Mebeverine acid D5 is the deuterium labeled Mebeverine Acid; Mebeverine Acid is a metabolite of Mebeverine, that is an antispasmodic.
  • HY-101384A
    Ro 10-5824 dihydrochloride

    Dopamine Receptor Others
    Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with Ki of 5.2 nM.
  • HY-104046
    Octaaminocryptand 1

    Others Others
    Octaaminocryptand 1 is an aminocryptand ligand.
  • HY-111644
    6-Methyl-5-azacytidine

    DNA Methyltransferase Others
    6-Methyl-5-azacytidine is a potent DNMT inhibitor.
  • HY-128387
    2,3-Butanediol

    Endogenous Metabolite Others
    2,3-Butanediol is a butanediol derived from the bioconversion of natural resources.
  • HY-107819
    5α-Cholestan-3β-ol

    Dihydrocholesterol; 5α-Cholestanol; NSC 18188

    Endogenous Metabolite Others
    5α-Cholestan-3β-ol is a derivitized steroid compound, which is isolated from the testes of White Carneau pigeons.
  • HY-N7091
    Atrazine

    Others Others
    Atrazine is principally used for control of certain annual broadleaf and grass weeds. Atrazine inhibits photophosphorylation but typically does not result in lethality or permanent cell damage in the short term.
  • HY-115433
    α-Muricholic acid

    Endogenous Metabolite Others
    α-Muricholic acid is the most abundant primary bile acid in rodents.
  • HY-13938
    Iretol

    Endogenous Metabolite Others
    Iretol (2,4,6-trihydroxyanisole) is a a degradation product of a glucoside obtained from Iris Jorentina. Iretol is an intermediate in the synthesis of natural isoflavones, such as Tectorigenin, Irigenin and Caviunin.
  • HY-N6912
    Regelidine

    Others Others
    Regelidine is a natural product isolated from the stems of Tripterygium regelii.
  • HY-N6832
    Rebaudioside N

    Others Others
    Rebaudioside N is a minor steviol glycoside isolated from the leaves of Stevia rebaudiana Bertoni.
  • HY-G0009
    Ritonavir metabolite

    Desthiazolylmethyloxycarbonyl Ritonavir

    Drug Metabolite Others
    Ritonavir metabolite is a metabolite of Ritonavir, which is a HIV protease inhibitor.
  • HY-130803
    5-Methyl-5,6-dihydrouridine

    Others Others
    5-Methyl-5,6-dihydrouridine is a minor constituent in the chromosomal RNA of the rat ascites tumor. 5-Methyl-5,6-dihydrouridine can be used for nucleic acid modification.
  • HY-135893
    SGK1-IN-2

    SGK Others
    SGK1-IN-2 (14h) is a selective SGK1 (serum and glucocorticoid regulated kinase 1) inhibitor, with an IC50 of 5 nM at 10 μM ATP concentration.
  • HY-15236S
    PSI-6206 13CD3

    RO-2433 13CD3; GS-331007 13CD3; Sofosbuvir metabolite GS-331007 13CD3

    HCV Others
    PSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.
  • HY-W048688
    Fmoc-Trp(Me)-OH

    Others Others
    Fmoc-Trp(Me)-OH is synthesized by N-(9-Fluorenylmethoxycarbonyloxy)succinimide (Fmoc-ONSu) and 1-Methyl-Ltrypthophan and can be used for protein or peptide synthesis.
  • HY-107846
    Xylan

    Others Others
    Xylan represents the main hemicellulose component in the secondary plant cell walls of flowering plants. Xylan is a polysaccharide made from units of xylose and contains predominantly β-D-xylose units linked as in cellulose.
  • HY-N6088
    Isoginsenoside Rh3

    Others Others
    Isoginsenoside-Rh3 is a triterpenoid saponin from the fruits of Panax ginseng C. A. Mey.
  • HY-59132
    2-Amino-1-phenylethanol

    Endogenous Metabolite Others
    2-Amino-1-phenylethanol is an analogue of noradrenaline.
  • HY-N4165
    Arnidiol

    Others Others
    Arnidiol is a pentacyclic triterpene isolated from Barleria Longiflora Linn F..
  • HY-N0219
    (+)-Bicuculline

    d-Bicuculline

    GABA Receptor Others
    (+)-Bicuculline is a light-sensitive competitive antagonist of GABA-A receptor.
  • HY-N4131
    25R-Inokosterone

    Others Others
    25R-Inokosterone is a phytoecdysone isolated from Achyranthis Radix.
  • HY-B0302
    Etidronic acid

    HEDPA; HEDP

    Apoptosis Others
    Etidronic acid (HEDPA) is a bisphosphonate used in detergents, water treatment, cosmetics and pharmaceutical treatment.
  • HY-113381
    2-Hydroxybutyric acid

    α-Hydroxybutyric acid

    Others Others
    2-Hydroxybutyric acid (α-Hydroxybutyric acid ) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite.
  • HY-125832
    PBDB-T

    Others Others
    PBDB-T is a wide bandgap polymer donor in Perylene diimide (PDI)-based polymer solar cells (PSCs).
  • HY-13102
    UK-383367

    Procollagen C Proteinase Others
    UK-383367 (UK 383367) is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase) with IC50 of 44 nM; Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).
  • HY-N2178
    Saikosaponin F

    Others Others
    Saikosaponin F is a component found in Bupleurum (B.) falcatum L.
  • HY-N0412
    Sesamoside

    Others Others
    Sesamoside is a iridoid isolated from the aerial part of  Phlomis linearifolia. Sesamoside has antiodant and antiglycation activities.
  • HY-N2120
    Dichotomitin

    Others Others
    Dichotomitin is an isoflavonoid isolated from the rhizomes of Belamcanda chinensis (L.) DC.
  • HY-111641
    3'-Azido-3'-deoxy-5-fluorocytidine

    Nucleoside Antimetabolite/Analog Others
    3'-Azido-3'-deoxy-5-fluorocytidine (Compound 12) is a cytidine derivative.
  • HY-18874
    p38-α MAPK-IN-1

    p38 MAPK Autophagy Others
    p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay.
  • HY-125847
    Salvianolic acid F

    Others Others
    Salvianolic acid F is a synthesized polyphenolic acid.
  • HY-N0771
    L-Isoleucine

    Endogenous Metabolite Others
    L-isoleucine is a nonpolar hydrophobic amino acid. L-Isoleucine is an essential amino acid.
  • HY-N2186
    Leucoside

    Others Others
    Leucoside is a natural compound isolated from tea seed extract.
  • HY-N2620
    Rutaevin

    Reactive Oxygen Species Others
    Rutaevin is isolated from the fruits of Euodia rutaecarpa. Rutaevin inhibits NO production in LPS-induced RAW 264.7 macrophages.
  • HY-B1449
    Uridin

    β-Uridine

    Endogenous Metabolite Others
    Uridin is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond.
  • HY-135381
    3-Oxo Atorvastatin

    Others Others
    3-Oxo Atorvastatin is an impurity of 3-Oxo Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.
  • HY-W016349
    Chelidamic acid

    Others Others
    Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
  • HY-G0017S
    N-Desmethyl imatinib D8

    Norimatinib D8; Imatinib metabolite N-Desmethyl imatinib D8

    Drug Metabolite Others
    N-Desmethyl imatinib D8 (Norimatinib D8) is a deuterium labeled Imatinib metabolite N-Desmethyl Imatinib.
  • HY-N0729
    Linoleic acid

    Endogenous Metabolite Others
    Linoleic acid is a critical component of polyunsaturated fatty acids.
  • HY-W009326
    Laurocapram

    Others Others
    Laurocapram is a absorption enhancer and has been one of the most effective for substances of both lipophilic and hydrophilic nature.
  • HY-N0237
    Atractyloside A

    Others Others
    Atractyloside A is a natural TCM reference compound.
  • HY-113027
    p-Hydroxymandelic acid

    Endogenous Metabolite Others
    p-Hydroxymandelic acid is a valuable aromatic fine chemical and widely used for production of pharmaceuticals and food additives.
  • HY-N5087
    Nudicaucin A

    Others Others
    Nudicaucin A is a triterpenoid saponin isolated from Hedyotis nudicaulis.
  • HY-N3213
    Naringenin triacetate

    Others Others
    Naringenin triacetate is a flavonoid isolated from plant, exhibits a good binding affinity with multiple crystal structures of first bromodomain BRD4 (BRD4 BD1).
  • HY-D0937
    Methoxy-PMS

    1-Methoxy PMS; 1-Methoxyphenazine methosulfate

    Reactive Oxygen Species Others
    Methoxy-PMS (1-Methoxy PMS; 1-Methoxyphenazine methosulfate) is stable electron-transport mediator between NAD(P)H and tetrazolium dyes.
  • HY-W012846
    D-Threitol

    Endogenous Metabolite Others
    D-threitol serves as a antifreeze agent in the Alaskan beetle Upis ceramboides.
  • HY-105634
    Nomegestrol

    Progesterone Receptor Others
    Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.
  • HY-113161
    L-Octanoylcarnitine

    Endogenous Metabolite Others
    L-Octanoylcarnitine is the physiologically active form of octanoylcarnitine.
  • HY-B1092A
    Gluconate sodium

    D-Gluconic acid sodium salt; Sodium D-gluconate; D-Gluconate sodium salt

    Endogenous Metabolite Others
    Gluconate sodium (D-Gluconic acid sodium salt) is a corrosion and scale inhibitor of ordinary steel in simulated cooling water.
  • HY-B0764A
    Bucladesine calcium

    Dibutyryl cAMP calcium salt; DBcAMP calcium salt

    PKA Phosphodiesterase (PDE) Apoptosis Others
    Bucladesine calcium salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine calcium salt acts as a phosphodiesterase (PDE) inhibitor.
  • HY-103601
    (S,R,S)-AHPC-PEG4-N3

    VH032-PEG4-N3; VHL Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 4

    E3 Ligase Ligand-Linker Conjugate Others
    (S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
  • HY-N7039
    Mogroside IA-(1-3)-glucopyranoside

    Others Others
    Mogroside IA-(1-3)-glucopyranoside is isolated from Siraitia grosvenorii.
  • HY-12784S
    Cycloguanil D6

    Chlorguanide triazine D6

    Antifolate Others
    Cycloguanil D6 is the deuterium labeled Cycloguanil, which is a dihydrofolate reductase inhibitor.
  • HY-B1346
    DL-Glutamine

    (±)-Glutamine; DL-Gl

    Ferroptosis Others
    DL-Glutamine is used for biochemical research and drug synthesis.
  • HY-41700
    D-Alanine

    (R)-Alanine; Ba 2776; D-α-Alanine

    Endogenous Metabolite Others
    D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.
  • HY-16738A
    Eleclazine hydrochloride

    GS 6615 hydrochloride

    Sodium Channel Others
    Eleclazine hydrochloride is a novel late Na+ current inhibitor with IC50 value of 0.7 uM.
  • HY-N2161
    Apiopaeonoside

    Others Others
    Apiopaeonoside is a natural product isolated from the root of Paeonia suffruticosa.
  • HY-N7060
    Helicin

    Others Others
    Helicin, found in Rosaceae, is a moderate syrB inducer. Helicon can be hydrolyzed by BglY enzyme.
  • HY-P0004
    Lysipressin

    Lysine vasopressin; [Lys8]-Vasopressin

    Others Others
    Lysipressin is Antidiuretic hormone that have been found in pigs and some marsupial families. Induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase.
  • HY-P1799
    [pTyr5] EGFR 988-993

    Phosphatase Others
    [pTyr5] EGFR (988-993) is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993). [pTyr5] EGFR (988-993) is often complexed with the catalytically inactive protein-tyrosine phosphate 1B (PTP1B).
  • HY-N7259
    (+)-Isomenthone

    Others Others
    (+)-Isomenthone is an isomenthone isolated from Ziziphora clinopodioides Lam.. (+)-Isomenthone is an isomer of L-Menthone.
  • HY-N2262
    8-Geranyloxypsoralen

    Cytochrome P450 Others
    8-Geranyloxypsoralen is a furanocoumarin isolated from grapefruit, acts as a potent inhibitor of P450 3A4 (CYP3A4) with an IC50 of 3.93 μM.
  • HY-N0695
    Schisantherin B

    Gomisin-B; Wuweizi ester-B; Schisantherin-B

    Amyloid-β Others
    Schisantherin B (Gomisin-B; Wuweizi ester-B; Schisantherin-B) is a natural product.
  • HY-17567A
    Heparin sodium salt

    Sodium heparin; Sodium heparinate

    Autophagy Others
    Heparin sodium salt (Sodium heparin) is an anticoagulant which binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa.
  • HY-B2030
    Propanil

    Others Others
    Propanil is a widely used contact herbicide, mainly use in rice production.
  • HY-B1337
    Choline chloride

    Others Others
    Choline chloride is an organic compound and a quaternary ammonium salt, an acyl group acceptor and choline acetyltransferase substrate, also is an important additive in feed especially for chickens where it accelerates growth.
  • HY-113352
    7-Methylguanine

    Endogenous Metabolite Others
    7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents, and used as a probe of protein–DNA interactions and a key component of DNA sequencing method.
  • HY-N3520
    Deapi-platycodin D3

    Others Others
    Deapi-platycodin D3 is a triterpenoid saponin from the roots of Platycodon grandiflorum.
  • HY-N2592
    Isobutylshikonin

    Others Others
    Isobutylshikonin is a kind of shikonin pigments from hairy root culture of Lithospermum canescens.
  • HY-N1131
    Triacetonamine

    2,2,6,6-Tetramethyl-4-piperidone

    Others Others
    Triacetonamine is useful as an intermediate for the synthesis of pharmaceutical products, pesticides and photostabilizers for polymers. Triacetonamine is an artifact of plant and fungal extracts using acetone and ammonium hydroxide or natural occurrence of ammonium salts in various steps of the isolation procedures. TAA is the main component of the pyrolysis oil.
  • HY-P1528
    Autocamtide 2, amide

    CaMK Autophagy Others
    Autocamtide 2, amide is a substrate (100 μM final concentration) for CaMK family assays.
  • HY-N7258
    Neohesperidose

    Others Others
    Neohesperidose is a disaccharide isolated from species of typha.
  • HY-B0782S
    Acetazolamide D3

    Carbonic Anhydrase Others
    Acetazolamide D3 is deuterium labeled Acetazolamide, which is a potent carbonic anhydrase (CA) inhibitor.
  • HY-P1880
    β-Amyloid 12-20

    Amyloid-β Others
    β-Amyloid (12-20) is a peptide fragment of β-Amyloid.
  • HY-100650
    Carbodenafil

    Others Others
    Carbodenafil is a Sildenafil (UK-92480) related compound found in health foods. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
  • HY-N2396
    N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide

    Others Others
    N-​(3-​Methoxybenzyl-​(9z,​12z)​-​octadecadienamide (Macamide impurity 10), the impurity of Macamide isolated from Lepidium meyenii.
  • HY-113099
    Indolelactic acid

    Endogenous Metabolite Others
    Indolelactic acid is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures.
  • HY-109506
    DPPC

    129Y83

    Endogenous Metabolite Others
    DPPC is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers.
  • HY-N6741
    β-Zearalenol

    Others Others
    β-Zearalenol is a non-steroidal estrogenic mycotoxin synthesized by Fusarium species. β-Zearalenol potentially influences transcription and effects gene expression on translational level.
  • HY-W010970
    5'-Guanylic acid disodium salt

    5'-GMP (disodium salt); 5'-guanosine monophosphate (disodium salt)

    Endogenous Metabolite Others
    5'-Guanylic acid disodium salt (5'-GMP disodium salt) is composed of guanine, ribose, and phosphate moieties and it is a nucleotide monomer in messenger RNA. Guanosine derivatives are involved in intracellular signal transduction and have been identified in repetitive genomic sequences in telomeres, in ribosomal DNA, immunoglobulin heavy‐chain switch regions, and in the control regions of proto-oncogenes.
  • HY-N1371
    Clinodiside A

    Others Others
    Clinodiside A is isolated from the Chinese medicinal herb Clinopodium chinensis.
  • HY-108585
    VU591 hydrochloride

    Potassium Channel Others
    VU591 hydrochloride is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM.
  • HY-12470
    PF-4800567

    Casein Kinase Others
    PF-4800567 is a potent and selective inhibitor of casein kinase 1ϵ (CK1ϵ), with an IC50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM).
  • HY-N3164
    Oblongine

    Others Others
    Oblongine is isolated from the tuber of Stephania cambodica.
  • HY-112777
    Kinesore

    Others Others
    Kinesore is an inhibitor of the KLC2-SKIP Interaction.
  • HY-N6667
    Glucovanillin

    Others Others
    Glucovanillin extracted from green pods and simultaneously transformed to vanillin by a combination of enzyme activities involving cell wall degradation and glucovanillin hydrolysis.
  • HY-112292
    GW806742X

    Mixed Lineage Kinase VEGFR Others
    GW806742X is a Mixed Lineage Kinase Domain-Like protein (MLKL) inhibitor which binds the MLKL pseudokinase domain with a Kd value of 9.3 μM and has anti-necroptosis activity. GW806742X has activity against VEGFR2.
  • HY-W001179
    2,5-Dihydroxybenzoic acid

    Endogenous Metabolite FGFR Others
    2,5-Dihydroxybenzoic acid is a derivative of benzoic and a powerful inhibitor of fibroblast growth factors.
  • HY-N0724
    Mesaconitine

    TNF Receptor Others
    Mesaconitine is the main active component of genus aconitum plants.
  • HY-N1432
    Lirioprolioside B

    Others Others
    Lirioprolioside B is a steroidal glycoside isolated from the underground organs of Liriope spicata var. prolifera.
  • HY-N4085
    Vitexin 4'-glucoside

    4'-O-Glucosylvitexin

    Others Others
    Vitexin 4'-glucoside is a leaf flavonoid identified from Briza stricta.
  • HY-N2261
    Ipecoside

    Others Others
    Ipecoside is an alkaloid isolated from Psychotria.
  • HY-N2269
    p-Hydroxyphenethyl anisate

    4-Hydroxyphenethyl anisate

    Others Others
    p-Hydroxyphenethyl anisate is a main constituent of Notopterygium Radix.
  • HY-17532
    Haloxon

    Parasite Others
    Haloxon is an organophosphorus anthelmintic once used against nematodes of the abomasum and small intestine in ruminants.
  • HY-103614
    Thalidomide-O-amido-C8-NH2 (TFA)

    Cereblon Ligand -Linker Conjugates 2 (TFA); E3 Ligase Ligand-Linker Conjugates 20 (TFA)

    E3 Ligase Ligand-Linker Conjugate Others
    Thalidomide-O-amido-C8-NH2 TFA (Cereblon Ligand -Linker Conjugates 2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
  • HY-12542A
    Dantrolene sodium hemiheptahydrate

    Dantrolene sodium hydrate

    Calcium Channel Autophagy Others
    Dantrolene sodium hemiheptahydrate is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction.
  • HY-112820
    Chlorantraniliprole

    Others Others
    Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ∼300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC50, 14 μM).
  • HY-N6082
    Rhein 8-Glucoside

    Rhein 8-O-β-D-Glucopyranoside

    Others Others
    Rhein 8-Glucoside (Rhein 8-O-β-D-Glucopyranoside) is an anthraquinone glycoside that has been found in rhubarb. Purgative activity.
  • HY-N6260
    4-O-beta-Glucopyranosyl-cis-coumaric acid

    Others Others
    4-O-beta-Glucopyranosyl-cis-coumaric acid is a natural compound isolated formn Nelumbo nucifera Gaertn.
  • HY-B0407AS
    Chlorpromazine D6 hydrochloride

    Dopamine Receptor 5-HT Receptor Sodium Channel Potassium Channel Others
    Chlorpromazine D6 hydrochloride is the deuterium labeled Chlorpromazine. Chlorpromazine is an inhibitor of dopamine receptor, 5-HT receptor, potassium channel, sodium channel.
  • HY-N7058
    cis-​Jasmone

    Others Others
    Cis-Jasmone is a plant-derived natural product. Cis-Jasmone is constitutively released by many flowers and sometimes by leaves as an attractant for pollinators or as a chemical cue for host location by insect flower herbivores. Cis-Jasmone treatment of crop plants not only induces direct defense against herbivores, but also induces indirect defense by releasing VOCs that attract natural enemies.
  • HY-N2218
    Jionoside B1

    Others Others
    Jionoside B1 is a phenylpropanoid isolated from herbs of Eriophyton wallichii.
  • HY-N6930
    Shikonofuran A

    Others Others
    Shikonofuran A is a natural product isolated from the root of Lithosperraum erythrorhizon Sieb.
  • HY-100346
    PK14105

    Others Others
    PK14105 is a biological evaluation as a potential radioligand for PET studies of PBBS receptors.
  • HY-W012570
    Decyl aldehyde

    Endogenous Metabolite Others
    Decyl aldehyde is a simple ten-carbon aldehyde. Decyl aldehyde is a bacterial luciferase substrate.
  • HY-N0701
    (-)-Asarinin

    Others Others
    (-)-Asarinin is a extract lignan from Zanthoxylum armatum, mainly produced in roots of this herb[1].
  • HY-N6731
    Hydrolyzed Fumonisin B2

    Others Others
    Hydrolyzed Fumonisin B2 (HFB2) is a hydrolysis product of fumonisins (HF), which retains biological activity. Hydrolyzed Fumonisin B2 (HFB2) exhibits phytotoxicity.
  • HY-N6006
    1,3,6-Tri-O-galloyl-beta-D-glucose

    1,3,6-Tri-O-galloyl-β-D-glucose

    Others Others
    1,3,6-Tri-O-galloyl-beta-D-glucose (1,3,6-Tri-O-galloyl-β-D-glucose) is a phenolic compound in Black Walnut Kernels.
  • HY-B0754A
    Hematoporphyrin dihydrochloride

    Hematoporphyrin IX dihydrochloride

    Others Others
    Hematoporphyrin dihydrochloride is a substrate for affinity chromatography of heme-binding proteins.
  • HY-113972A
    (E/Z)-Methyl mycophenolate

    Others Others
    (E/Z)-Methyl mycophenolate is a racemic compound of (Z)-Methyl mycophenolate and (E)-Methyl mycophenolate isomers. Methyl mycophenolate is a methyl ester of mycophenolic acid. Methyl mycophenolate can be used to synthesize mycophenolic acid β-D-glucuronide and phenolic glycosides.
  • HY-103243
    TCPOBOP

    Bcl-2 Family Others
    TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins.
  • HY-113493
    4-Pyridoxic acid

    Endogenous Metabolite Others
    4-Pyridoxic acid is a catabolic product of vitamin B6 which is excreted in the urine.
  • HY-114117
    Tyclopyrazoflor

    Others Others
    Tyclopyrazoflor is an anthranilamide compound with pesticidal activity.
  • HY-113437A
    1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium

    Endogenous Metabolite Others
    1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium (compound 3-F7) is a phosphatidic acid and a human endogenous metabolite
  • HY-N6909
    Neochebulagic acid

    Others Others
    Neochebulagic acid is isolated from Phyllanthus emblica L..
  • HY-N0113
    Hordenine

    Ordenina; Peyocactine

    Others Others
    Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production.
  • HY-N2200
    Precyasterone

    Others Others
    Precyasterone is a natural product isolated from the dried roots of Cyathula capitata.
  • HY-B1173
    (+)-Camphor

    D-(+)-Camphor; (1R)-(+)-Camphor

    Bacterial Others
    (+)-Camphor is an ingredient in cooking, and as an embalming fluid for medicinal purposes,
  • HY-W012575
    2,4-Dihydroxybenzoic acid

    Endogenous Metabolite Others
    2,4-Dihydroxybenzoic acid is a degradation product of cyaniding glycoside from tart cheeries in cell culture.
  • HY-N6965
    Kaempferol-3-O-(6'''-trans-p-coumaroyl-2''-glucosyl)rhamnoside

    Others Others
    Kaempferol-3-O-(6'''-trans-p-coumaroyl-2''-glucosyl)rhamnoside is a natural antioxidant from herbal medicines.
  • HY-N6921
    11-​Oxomogroside III

    Others Others
    11-Oxomogroside III is a cucurbitane triterpene glycoside isolated from in Siraitia grosvenorii fruits.
  • HY-12770
    Mebeverine alcohol

    Mebeverine metabolite Mebeverine alcohol

    Drug Metabolite Others
    Mebeverine alcohol is a metabolite of Mebeverine, which is a musculotropic antispasmodic drug.
  • HY-30215
    (S)-Leucic acid

    Endogenous Metabolite Others
    (S)-Leucic acid is an amino acid metabolite.
  • HY-B2221B
    Hydroxyethyl cellulose

    2-Hydroxyethyl cellulose; Cellulose hydroxyethyl ether

    Others Others
    Hydroxyethyl cellulose is a non-ionic, water soluble, modified cellulose polymer used as a thickening agent for aqueous cosmetic and personal care formulations.
  • HY-113107
    3-Hydroxydodecanoic acid

    Endogenous Metabolite Others
    3-Hydroxydodecanoic acid is a medium-chain fatty acid associated with fatty acid metabolic disorders.
  • HY-12691
    BFCAs-1

    Others Others
    BFCAs-1 is a polyamino polycarboxylic bifunctional chelating agent(BFCAs); a broad range of applications in chemistry, biology and medicine and diagnostic imaging (MRI, SPECT, PET).
  • HY-N0867
    Dodecanoic acid ingenol ester

    Others Others
    Dodecanoic acid ingenol ester is a natural compound.
  • HY-112904
    XRK3F2

    Autophagy Others
    XRK3F2 is an inhibitor of p62 (Sequestosome-1)-ZZ/ domain.
  • HY-D1024
    Coelenterazine h

    2-Deoxycoelenterazine; CLZN-h

    Others Others
    Coelenterazine h is a derivative of Coelenterazine. Coelenterazine h is more sensitive to Ca 2+ than is the native complex, thus providing a valuable tool for measuring small changes in Ca 2+ concentrations.
  • HY-B0750
    Dolasetron

    MDL-73147

    5-HT Receptor Others
    Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.
  • HY-15954A
    NVP-CGM097 stereoisomer

    CGM097 stereoisomer

    Others Others
    NVP-CGM097 (stereoisomer) is a stereoisomer of NVP-CGM097, with no special bioactivity. NVP-CGM097 is a potent and selective MDM2 inhibitor.
  • HY-N6876
    Secologanoside

    Elastase Others
    Secologanoside is a triterpenoid isolated from Poraqueiba sericea, weakly inhibits elastase with an IC50 of 164 μg/mL. Secologanoside is moderate cytotoxic to fibroblasts.
  • HY-B1972
    Napropamide

    Napropamid

    Others Others
    Napropamide is a selective systemic amide herbicide used to control a number of annual grasses and broad-leaved weeds.
  • HY-N0748
    Oxypaeoniflorin

    Others Others
    Oxypaeoniflorin is a natural product derived from Radix Paeoniae Rubra and Radix Paeoniae Alba.
  • HY-W015495
    L-Dihydroorotic acid

    Endogenous Metabolite Others
    L-Dihydroorotic acid can reversibly hydrolyze to yield the acyclic L-ureidosuccinic acid by dihydrowhey enzyme.
  • HY-N1155
    Theviridoside

    Others Others
    Theviridoside is a natural iridoid glucoside found in the leaves of Cerbera odollam, it has cytotoxicity.
  • HY-Y0781
    Pyruvic acid

    Acetylformic acid

    Endogenous Metabolite Others
    Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats.
  • HY-111744
    Deacetylanisomycin

    Others Others
    Deacetylanisomycin is a potent growth regulator in plants and an inactive derivative of Anisomycin. Anisomycin is a potent protein synthesis inhibitor .
  • HY-N2634
    Uvarigranol B

    Others Others
    Uvarigranol B, a polyoxygenated cyclohexene, is obtained from the roots of Uvaria grandiflora Roxb (Annonaceae).
  • HY-W009948
    Vanillin acetate

    Others Others
    Vanillin acetate is easily synthesized from vanillin by treatment with acetic anhydride.
  • HY-113114
    Tetrahydrocortisone

    Endogenous Metabolite Others
    Tetrahydrocortisone is a stress-induced hormone. Tetrahydrocortisone is also a urinary metabolite of Cortisone derived from the reduction of Cortisone by 5-reductase.
  • HY-108526
    AC-55649

    RAR/RXR Autophagy Others
    AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.
  • HY-B0137A
    Prilocaine hydrochloride

    Na+/K+ ATPase Others
    Prilocaine hydrochloride is an amino amide type compound that used for anesthesia.
  • HY-12780S
    6-beta-Naloxol D5 hydrochloride

    6β-Naloxol D5 hydrochloride

    Opioid Receptor Others
    6-beta-Naloxol D5 hydrochloride is the deuterium labeled 6-beta-Naloxol, which is an opioid antagonist closely related to naloxone.
  • HY-B0484
    Buflomedil hydrochloride

    Others Others
    Buflomedil hydrochloride is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease.
  • HY-B1880
    Oxadiazon

    Others Others
    Oxadiazon is a preemergent herbicide.
  • HY-14342
    MK-5046

    Bombesin Receptor Others
    MK-5046 is a novel BRS-3 agonist, binds to BRS-3 with high affinity (mouse Ki = 1.6 nM, human Ki = 25 nM).
  • HY-112895A
    (R)-UT-155

    Androgen Receptor Others
    (R)-UT-155 (compound 11) is a selective androgen receptor degrader (SARD) ligand. Less active than the S-isomer.
  • HY-N4249
    Perisesaccharide B

    Others Others
    Perisesaccharide B is an oligosaccharide isolated from the root barks of Periploca sepium.
  • HY-N1753
    3-(4-Hydroxyphenyl)-1-propanol

    Dihydro-p-coumaryl alcohol; 3-(p-Hydroxyphenyl)propyl alcohol

    Others Others
    3-(4-Hydroxyphenyl)-1-propanol is used in the synthesis of (-)-centrolobine.
  • HY-N0744
    Senkyunolide H

    Others Others
    Senkyunolide H is a natural compound isolated from Ligusticum chuanxiong Hort.
  • HY-N4162
    3-Oxo-21α-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone

    Others Others
    3-Oxo-21α-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone is a cytotoxic tirucallane C26 triterpenoid isolated from the stem barks of Aphanamixis grandifolia.
  • HY-100242
    Mivotilate

    YH439

    Aryl Hydrocarbon Receptor Others
    Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR), and acts as a hepatoprotective agent.
  • HY-17599
    Piperazine citrate

    Parasite Others
    Piperazine Citrate is an organic compound that consists of a six-membered ring, containting two nitrogen atoms at opposite positions in the ring; first introduced in 1953 as an Anthelmintic.
  • HY-104065A
    Pyrotinib Racemate

    SHR-1258 Racemate

    EGFR Others
    Pyrotinib Racemate is the racemate of Pyrotinib. Pyrotinib is a potent and selective EGFR/HER2 dual inhibitor.
  • HY-N0320
    Salvianolic acid D

    Others Others
    Salvianolic acid D, isolated from Salvia miltiorrhiza, is a potential antiplatelet activity compound.
  • HY-B1084
    Cinoctramide

    Others Others
    Cinoctramide is an intermediate of pharmaceutical synthesis.
  • HY-B0331AS
    Enalapril D5 maleate

    MK-421 D5 maleate

    Angiotensin-converting Enzyme (ACE) Others
    Enalapril (D5 maleate) (MK-421 (D5 maleate)) is deuterium labeled Enalapril, which is an angiotensin converting enzyme (ACE) inhibitor.
  • HY-113217
    Cholesteryl oleate

    Endogenous Metabolite Others
    Cholesteryl oleate is a cholesteryl ester.
  • HY-N2624
    Liguiritigenin-7-O-D-apiosyl-4'-O-D-glucoside

    Others Others
    Liguiritigenin-7-O-D-apiosyl-4'-O-D-glucoside is a flavanone glycoside isolated from Glycyrrhizia inflate.
  • HY-W062542
    2-(1-Methyl-1H-imidazol-4-yl)ethan-1-amine

    Endogenous Metabolite Others
    2-(1-Methyl-1H-imidazol-4-yl)ethan-1-amine is a histamine (Him) metabolite.
  • HY-N7054
    Volemitol

    D-Volemitol

    Others Others
    Volemitol (D-Volemitol) is a seven-carbon sugar alcohol that fulfills several important physiological functions in certain species of the genus Primula. Volemitol is the major nonstructural carbohydrate in leaves of all stages of development. Volemitol functions as a photosynthetic product, phloem translocate (phloem-mobile), and storage carbohydrate. Volemitol biosynthesis proceeds by a novel, NADPH-dependent, ketose reductase (sedoheptulose reductase).
  • HY-N2207
    rel-(8R,8'R)-Dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydro-furan

    Others Others
    rel-(8R,8'R)-Dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydro-furan is a chemical constituent of the fruit of Myristica fragrans.
  • HY-129770A
    D-Methionine sulfoxide hydrochloride

    Others Others
    D-methionine sulfoxide hydrochloride is the D-isomer of Methionine sulfoxide hydrochloride. Methionine sulfoxide is an oxidation product of methionine. Methionine is the limiting amino acid in milk or leguminous proteins, which is easily oxidized during the course of storage or processing.
  • HY-125658
    Biotinyl tyramide

    Others Others
    Biotinyl tyramide is a biotin derivative used for tyramide signal amplification (TSA), as a reagent to amplify both immunohistochemical signals and in situ hybridization protocols.
  • HY-111793
    NUCC-390

    CXCR Others
    NUCC-390 is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 can induce internalization of CXCR4 receptors.
  • HY-N7017
    19-Oxocinobufagin

    Others Others
    19-Oxocinobufagin is a bufadienolide in toad venom.
  • HY-16011
    NE 10790

    3-PEHPC

    Others Others
    NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.
  • HY-P1895
    β-Amyloid 33-40

    Amyloid-β Others
    β-Amyloid (33-40) is a peptide consisting of amino acid of 33 to 40 of beta amyloid protein.
  • HY-103028A
    GSK963

    RIP kinase Others
    GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro.
  • HY-107353
    Gadopentetic acid

    Gd-DTPA; gadolinium complex

    Others Others
    Gadopentetic acid (Gd-DTPA) is an paramagnetic contrast agent commonly implemented by a bolus intravenous injection (i.v.) in Dynamic contrast-enhanced MRI (DCE-MRI) studies. The initial concentration of Gadopentetic acid (Gd-DTPA) in the plasma ([Gd-DTPA0]) is an important parameter for DCE-MRI. [Gd-DTPA0] is related to the administered bolus dose and varies with subjects. A bolus of 0.025 mmol/kg Gd-DTPA offers shorter acquisition time and less exposure of subjects, with a half-life of 37.3 mins, a mean residence time of 53.8 mins, and an AUC of 3.37 ± 0.47 mmol/min/L.
  • HY-113165
    Isobutyryl-L-carnitine

    Endogenous Metabolite Others
    Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases. Isobutyryl-L-carnitine is a member of the class of compounds known as acyl carnitines.
  • HY-N0787
    Cryptochlorogenic acid

    4-Caffeoylquinic acid; 4-O-Caffeoylquinic acid

    Others Others
    Cryptochlorogenic acid is a natural product.
  • HY-120177
    KT182

    MAGL Others
    KT182 is a potent and selective inhibitor of α/β-hydrolase domain containing 6 (ABHD6), with an IC50 of 0.24 nM in Neuro2A cells.
  • HY-B1008
    4-Aminobenzoic acid

    PABA; Vitamin Bx; Vitamin H1

    Endogenous Metabolite Others
    4-Aminobenzoic acid is an intermediate in the synthesis of folate by bacteria, plants, and fungi.
  • HY-Y0989
    Acetophenone

    1-Phenylethan-1-One

    Others Others
    Acetophenone is an organic compound with simple structure.
  • HY-N6873
    GL3

    Others Others
    GL3, the major component of O. fragrans seeds, is a derivative based on both phenylethanoid and methyloleoside.
  • HY-N0853A
    Alisol A 24-acetate

    Alisol-A 24-acetate; Alisol A 24-monoacetate; Alisol A monoacetate

    Others Others
    Alisol A 24-acetate is a natural product.
  • HY-111842
    PROTAC CRABP-II Degrader-3

    SNIPER PROTAC Others
    PROTAC CRABP-II Degrader-3 is a potent cellular retinoic acid binding protein (CRABP-II) degrader based on cIAp1.
  • HY-N6028
    Darutoside

    Others Others
    Darutoside is a diterpenoid isolated from Siegesbeckia.
  • HY-N4273
    Oxyimperatorin

    (±)-Heraclenin

    Others Others
    Oxyimperatorin ((±)-Heraclenin) is a coumarin isolated from Angelica dahurica.
  • HY-N6824
    Hydroxy-β-sanshool

    Others Others
    Hydroxy-β-sanshool is an alkylamide exists in Zanthoxylum bungeanum oil and Zanthoxylum schinifolium oil.
  • HY-B0969
    Cresol

    Cresol mixture of isomers; Methylphenol; Tricresol

    Autophagy Mitophagy Others
    Cresol is organic compound,is a widely occurring natural and manufactured group of aromatic organic compounds.
  • HY-B0137
    Prilocaine

    Na+/K+ ATPase Others
    Prilocaine is an amino amide type compound that used for anesthesia.
  • HY-10912
    Fexaramine

    FXR Autophagy Others
    Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity relative to natural compounds.
  • HY-N1458
    Isoschaftoside

    Others Others
    Isoschaftoside, a C-glycosylflavonoid from Desmodium uncinatum root exudate, can inhibit growth of germinated S. hermonthica radicles.
  • HY-I0636
    (R)-Apremilast

    (R)-CC-10004

    Others Others
    (R)-Apremilast ((R)-CC-10004) is a enantiomer of Apremilast.
  • HY-113079
    Argininic acid

    Endogenous Metabolite Others
    Argininic acid is an α-amino acid that is used in the biosynthesis of proteins.
  • HY-B0284S
    Nifedipine D6

    BAY-a-1040 D6

    Calcium Channel Others
    Nifedipine D6 (BAY-a-1040 D6) is deuterium labeled nifedipine, and nifedipine is a potent calcium channel blocker.
  • HY-13567S
    Bendamustine D4

    SDX-105 D4

    DNA Alkylator/Crosslinker Others
    Bendamustine D4 is the deuterium labeled Bendamustine. Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.
  • HY-N2251
    Hosenkoside C

    Others Others
    Hosenkoside C is a baccharane glycoside isolated from the seeds of Impatiens balsamina.
  • HY-B2066
    Clofentezine

    Others Others
    Clofentezine, a growth inhibitor, has sublethal effects on life-table parameters of Tetranychus urticae Koch females.
  • HY-N7135
    Tropolone

    Tyrosinase Others
    Tropolone, a  tropone derivative with a hydroxyl group in the 2-position, is a precursor of manyazulene derivatives such as methyl 2-methylazulene-1-carboxylate. Tropolone is a potent inhibitor of mushroom tyrosinase with a IC50 of 0.4 μM, and the inhibition can be reversed by dialysis or by excess CU 2+.
  • HY-P0295
    Gly-Arg-Gly-Asp-Ser

    Integrin Others
    Gly-Arg-Gly-Asp-Ser is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC50 of ∼5 and ∼6.5 μM
  • HY-113126
    (S)-3-Hydroxyisobutyric acid

    Endogenous Metabolite Others
    (S)-3-Hydroxyisobutyric acid is an important interorgan metabolite, an intermediate in the pathways of l-valine and thymine and a good gluconeogenic substrate.
  • HY-N2155
    Tubuloside A

    Others Others
    Tubuloside A is a phenylethanoid glycoside with antioxidative effect and hepatoprotective activity.
  • HY-B0684
    Iopamidol

    B-15000; SQ-13396

    Others Others
    Iopamidol (B-15000; SQ-13396) is a nonionic, low-osmolar iodinated contrast agent.
  • HY-15594
    Phen-DC3

    DNA/RNA Synthesis Others
    Phen-DC3 is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively.
  • HY-N0915
    Melittoside

    Others Others
    Melittoside is a natural compound.
  • HY-N2158
    7-O-Methylmangiferin

    Others Others
    7-O-Methylmangifer is isolated from the cortexes of Polygala tenuifolia.
  • HY-P0031
    Cyclo(RADfK)

    Integrin Others
    Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.
  • HY-15985A
    CTX-0294885 hydrochloride

    Others Others
    CTX-0294885 hydrochloride is a sepharose-supported kinase capture reagent.
  • HY-103087
    FIN56

    Ferroptosis Others
    FIN56 is a specific inducer of ferroptosis.
  • HY-18253
    Udenafil

    DA8159

    Phosphodiesterase (PDE) Others
    Udenafil(DA8159) is a PDE5 inhibitor used in urology to treat erectile dysfunction.
  • HY-14930A
    Mirodenafil dihydrochloride

    SK-3530 dihydrochloride

    Phosphodiesterase (PDE) Others
    Mirodenafil dihydrochloride (SK3530 dihydrochloride) is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction.
  • HY-N1406
    6-Methylcoumarin

    Others Others
    6-Methylcoumarin is a synthetic fragrance widely used in cosmetics.
  • HY-N0254
    Hederacoside D

    Others Others
    Hederacoside D is one of the bioactive saponins from Hedera helix, and plays pivotal roles in the overall biological activity.
  • HY-14799
    Palovarotene

    R 667; Ro 3300074

    RAR/RXR Autophagy Others
    Palovarotene is a nuclear retinoic acid receptor γ (RAR-γ) agonist.
  • HY-112053
    DPPH

    2,2-Diphenyl-1-picrylhydrazyl

    Others Others
    DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a stable free radical that can be used to measure the radical scavenging activity of antioxidants. The odd electron of nitrogen atom in DPPH is reduced by receiving a hydrogen atom from antioxidants to the corresponding hydrazine. DPPH method may be utilized in aqueous and nonpolar organic solvents and can be used to examine both hydrophilic and lipophilic antioxidants.
  • HY-76504
    2,6-Dimethoxybenzoic acid

    Endogenous Metabolite Others
    2,6-Dimethoxybenzoic acid is a member of organic compounds known as o-methoxybenzoic acids and derivatives.
  • HY-101968
    2'-Deoxypseudoisocytidine

    Nucleoside Antimetabolite/Analog Others
    2'-Deoxypseudoisocytidine is a nucleoside analogue.
  • HY-N4215
    11(α)-Methoxysaikosaponin F

    Others Others
    11(α)-Methoxysaikosaponin F is a triterpenoid saponin isolated from Bupleurum marginatum Wall.ex DC(ZYCH) which is a promising therapeutic for liver fibrosis. 11(α)-Methoxysaikosaponin F has an IC50 of 387.7 nM with viability of hepatic stellate cells-T6 (HSCs-T6). Triterpenoid saponins have numerous targets, important network positions, and strong inhibitory activity.
  • HY-10163AS
    Dabigatran D4 hydrochloride

    BIBR-953 D4 hydrochloride

    Thrombin Others
    Dabigatran D4 hydrochloride is deuterium labeled Dabigatran, which is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM.
  • HY-N6959
    Osmundacetone

    Others Others
    Osmundacetone is a natural product isolated from Osmundae Rhizoma.
  • HY-106048
    Bredinin aglycone

    5-Hydroxy-1H-imidazole-4-carboxamide; SM-108

    Others Others
    Bredinin aglycone (5-Hydroxy-1H-imidazole-4-carboxamide) is a purine nucleotide analogue. Bredinin aglycone can be used to examine the efficiency of catalysts for the preparation of purine nucleotide analogues.
  • HY-19282A
    (5R)-BW-4030W92

    Others Others
    (5R)-BW-4030W92 is the R enantiomer of BW-4030W92. BW-4030W92 is a non-selective, voltage-, and use-dependent sodium channel antagonist.
  • HY-12085S2
    (Rac)-Apremilast D5

    (Rac)-CC-10004 D5

    Others Others
    (Rac)-Apremilast D5 ((Rac)-CC-10004 D5) is a deuterium labeled (R)-Apremilast. (R)-Apremilast ((R)-CC-10004) is a enantiomer of Apremilast.
  • HY-135326
    4-Propionamidophenol

    Others Others
    4-Propionamidophenol is a p-acetamidophenol analog.
  • HY-N0717
    L-Valine

    Endogenous Metabolite Others
    L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid.
  • HY-128389
    1-​Furfurylpyrrole

    Others Others
    1-Furfurylpyrrole has been identified as a potential contributor of flavor and aroma to popcorn.
  • HY-14268S
    Febuxostat D9

    Xanthine Oxidase Others
    Febuxostat D9 is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with Ki of 0.6 nM.
  • HY-14179
    PPQ-102

    CFTR Inhibitor

    CFTR Autophagy Others
    PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC50 of ~90 nM.
  • HY-B0342
    Meglumine

    Methylglucamine; Meglumin; Methylglucamin

    Others Others
    Meglumine is an amino sugar derived from sorbitol.
  • HY-N2431
    16-Methoxystrychnine

    Others Others
    16-Methoxystrychnine is a alkaloid.
  • HY-129770
    D-Methionine sulfoxide

    Endogenous Metabolite Others
    D-methionine sulfoxide is the D-isomer of Methionine sulfoxide. Methionine sulfoxide is an oxidation product of methionine. Methionine is the limiting amino acid in milk or leguminous proteins , which is easily oxidized during the course of storage or processing.
  • HY-135383A
    (3S,5R)-Pitavastatin calcium

    Others Others
    (3S,5R)-Pitavastatin cacium is the enantiomer of Pitavastatin. Pitavastatin is a potent HMG-CoA reductase inhibitor.
  • HY-11017AS
    (R)-Rivastigmine D6 tartrate

    AChE Others
    (R)-Rivastigmine D6 (tartrate) is the deuterium labeled (R)-Rivastigmine, which is an cholinesterase inhibitor.
  • HY-113404
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