pyruvate

By Targets:	PDHK (16) Pyruvate Kinase (19) AIM2 (1) Apoptosis (5) Autophagy (1) Bacterial (2) Cannabinoid Receptor (1) Chloride Channel (1) DNA/RNA Synthesis (1) Endogenous Metabolite (24) Fatty Acid Synthase (FASN) (3) Fluorescent Dye (1) Hexokinase (2) HIV (1) HSP (1) Influenza Virus (1) Insulin Receptor (2) Isotope-Labeled Compounds (3) Lactate Dehydrogenase (2) Mitochondrial Metabolism (6) Monocarboxylate Transporter (2) NF-κB (1) NKCC (1) NO Synthase (1) Nucleoside Antimetabolite/Analog (1) Parasite (2) PPAR (2) Pyk2 (1) Reactive Oxygen Species (7) STAT (1) TNF Receptor (1)
By Research Areas:	Cancer (34) Cardiovascular Disease (5) Endocrinology (2) Infection (4) Inflammation/Immunology (11) Metabolic Disease (38) Neurological Disease (5)

Targets Recommended: Pyruvate Kinase PDHK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2891

Pyruvate Oxidase, Microorganisms PoxB	Endogenous Metabolite	Others
Pyruvate Oxidase, Microorganisms (PoxB) is a thiamine pyrophosphate-dependent oxidase that catalyzes the oxidative decarboxylation of pyruvate to acetyl phosphate, carbon dioxide and water. Pyruvate oxidase is an important enzyme in bacterial metabolism and is often used in biochemical research .

HY-142684

Pyruvate Carboxylase-IN-1	Others	Cancer
Pyruvate Carboxylase-IN-1 (compound 37) is a potent inhibitor of pyruvate carboxylase (PC) with IC₅₀s of 0.204 and 0.104 μM in cell lysate-based and cell-based PC activity, respectively. Pyruvate Carboxylase-IN-1 is a natural analog of erianin. Pyruvate Carboxylase-IN-1 inhibites the enzymatic activity of PC, mediating the anticancer effect in human hepatocellular carcinoma (HCC) .

HY-142685

Pyruvate Carboxylase-IN-2	Others	Cancer
Pyruvate Carboxylase-IN-2 (compound 29) is a potent inhibitor of pyruvate carboxylase (PC) with IC₅₀s of 0.065 and 0.097 μM in cell lysate-based and cell-based PC activity, respectively. Pyruvate Carboxylase-IN-2 is a natural analog of erianin. Pyruvate Carboxylase-IN-2 inhibites the enzymatic activity of PC, mediating the anticancer effect in human hepatocellular carcinoma (HCC) .

HY-P2989

Pyruvate carboxylase	Endogenous Metabolite	Metabolic Disease
Pyruvate carboxylase is a biotin-containing enzyme that catalyzes the HCO3 ⁻ and MgATP dependent carboxylation of pyruvate to form oxaloacetate. Pyruvate carboxylase plays an essential role in controlling whole-body energetics through regulation of gluconeogenesis in the liver, synthesis of fatty acids in adipocytes, and insulin secretion in pancreatic β cells .

HY-P2806

Pyruvate Kinase, Microorganism PK; Fluorokinase	Endogenous Metabolite	Metabolic Disease
Pyruvate Kinase, Microorganism (PK) is a glycolytic enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP .

HY-Y1362

Ethyl pyruvate 5 Publications Verification
Ethyl pyruvate is a simple derivative of the endogenous metabolite pyruvate. Ethyl pyruvate is an HMGB1 release inhibitor. Ethyl pyruvate can induce apoptosis by autophagy. Ethyl pyruvate has anti-inflammatory, antioxidant and anti-tumor activity. Ethyl pyruvate can be used in the study of neurodegenerative diseases such as Alzheimer's and Parkinson's disease .

HY-Y1362S

*Ethyl pyruvate-d3*	Isotope-Labeled Compounds	Inflammation/Immunology
Ethyl pyruvate-d₃ is the deuterium labeled Ethyl pyruvate[1]. Ethyl pyruvate is a simple derivative of the endogenous metabolite, pyruvic acid. Ethyl pyruvate is an anti-inflammatory agent[2].

HY-W016203S

Sodium Phenyl-d5-pyruvate

Isotope-Labeled Compounds Others

Sodium Phenyl-d₅-pyruvate is the deuterium labeled Sodium Phenyl-pyruvate[1].

Sodium Phenyl-d5-pyruvate	Isotope-Labeled Compounds	Others
Sodium Phenyl-d₅-pyruvate is the deuterium labeled Sodium Phenyl-pyruvate[1].

HY-W015913

Sodium 2-oxopropanoate 5 Publications Verification Sodium pyruvate	Reactive Oxygen Species Endogenous Metabolite	Metabolic Disease
Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .

HY-P2876

Tryptophanase

Bacterial Infection

Tryptophanase, a bacterial enzyme, catalyzes degradation of tryptophan to indole, pyruvate and ammonia .

Tryptophanase	Bacterial	Infection
Tryptophanase, a bacterial enzyme, catalyzes degradation of tryptophan to indole, pyruvate and ammonia .

HY-19702

PKR activator 3	Pyruvate Kinase	Metabolic Disease Inflammation/Immunology Cancer
PKR activator 3 is a pyruvate kinase isoform PKR activator extracted from patent WO2014139144A1, compound 160. PKR activator 3 can be used for the research of PKR function related diseases, including cancer, diabetes, obesity, autoimmune disorders, and benign prostatic hyperplasia .

HY-138825

NCGC00188636	Pyk2	Metabolic Disease
NCGC00188636 is a novel covalent pyruvate kinase (PYK) inhibitor. NCGC00188636 blocks nucleotide binding to the active site of pyruvate kinase. NCGC00188636 can be used for the research of the metabolism of many organisms and cell types.

HY-W015913S1

Sodium 2-oxopropanoate-d3 Sodium pyruvate-d₃	Endogenous Metabolite Reactive Oxygen Species	Metabolic Disease
Sodium 2-oxopropanoate-d₃ is the deuterium labeled Sodium 2-oxopropanoate[1]. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[2][3].

HY-12689

Mitapivat AG-348	Pyruvate Kinase	Metabolic Disease
Mitapivat (AG-348) is an orally active pyruvate kinase allosteric activator. Mitapivat increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes, shows the potential to restore the activity of *PK (pyruvate* kinase)**-deficient glycolytic pathways. Mitapivat can be used in study of PK deficiency .

HY-P2977

N-Acetylneuraminate lyase (CgNal) Sialic acid aldolase (CgNal)	Endogenous Metabolite	Others
N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)) is a class I aldolase, is often used in biochemical studies. N-Acetylneuraminate lyase (CgNal) catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac) .

HY-114702

M77976 1 Publications Verification	PDHK	Metabolic Disease
M77976 is a specific ATP-competitive inhibitor of *PDK4 (pyruvate* dehydrogenase kinase isoforms 4), with an IC₅₀** of 648 μM. M77976 is potential for the research of obesity and diabetes .

HY-139573A

(Rac)-Etavopivat (Rac)-FT-4202	Pyruvate Kinase	Cardiovascular Disease
(Rac)-Etavopivat ((Rac)-FT-4202) is an isomer of Etavopivat (HY-139573). Etavopivat is an orally active erythrocyte pyruvate kinase-R (PKR) activator that can be used in studies of sickle cell disease and other haemoglobinopathies .

HY-147064

DL-4-Hydroxy-2-ketoglutarate lithium	Others	Others
DL-4-Hydroxy-2-ketoglutarate lithium is the substrate of 4-hydroxy-2-oxoglutarate aldolase (HOGA). DL-4-Hydroxy-2-ketoglutarate lithium can be cleaved by HOGA to produce pyruvate and glyoxylate .

HY-W015913S

Sodium 2-oxopropanoate-13C3 Sodium pyruvate-¹³C₃	Reactive Oxygen Species Endogenous Metabolite	Metabolic Disease
Sodium 2-oxopropanoate- ¹³C₃ is the ¹³C-labeled Sodium 2-oxopropanoate. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[1][2].

HY-146801

PDHK-IN-3	PDHK	Metabolic Disease Cancer
PDHK-IN-3 (compound 7) is a potent PDHK (pyruvate dehydrogenase kinase) inhibitor, with IC₅₀ values of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively .

HY-138559

GW604714X	Mitochondrial Metabolism	Neurological Disease
GW604714X is a potent inhibitor of mitochondrial respiration supported by pyruvate but not other substrates. GW604714X is a highly specific mitochondrial pyruvate carrier (MPC) inhibitor with a K_i <0.1 nM. GW604714X also inhibits L-lactate transport by the plasma membrane monocarboxylate transporter (MCT1), but at concentrations more than 4 orders of magnitude greater than the MPC .

HY-19330

DASA-58 10+ Cited Publications	Pyruvate Kinase	Metabolic Disease Cancer
DASA-58 is a potential pyruvate kinase isozyme (PKM2) allosteric activator. DASA-58 can be used for the research of metabolism and kinds of cancer .

HY-161337

PKL-IN-1	Pyruvate Kinase	Metabolic Disease
PKL-IN-1 (Compound 12a) is a potent pyruvate kinase L (PKL) inhibitor with IC₅₀ values of 0.07 μM and 0.18 μM for PKL and PKR subtypes, respectively. PKL-IN-1 can inhibit 96.6% PKL activity at 10 μM concentration .

HY-136882

TM-1	PDHK	Cancer
TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase (PDHK1). TM-1 inhibits PDHK1 and PDHK2 with IC₅₀s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation .

HY-D0713

7ACC2 5 Publications Verification	Monocarboxylate Transporter Mitochondrial Metabolism	Cancer
7ACC2 is a potent monocarboxylate transporter (MCT) inhibitor with an IC₅₀ of 11 nM for inhibition of [ ¹⁴C]-lactate influx. 7ACC2 is also a potent inhibitor of *mitochondrial pyruvate* transport**. 7ACC2 is an anticancer agent through inhibition of lactate flux .

HY-19992

3-Bromopyruvic acid 15+ Cited Publications Bromopyruvic acid; Hexokinase II Inhibitor II, 3-BP	Hexokinase Apoptosis Autophagy	Cancer
3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities .

HY-100550

MSDC 0160 2 Publications Verification Mitoglitazone; CAY10415	Insulin Receptor Mitochondrial Metabolism	Neurological Disease Endocrinology
MSDC 0160 (Mitoglitazone) is a mitochondrial target of thiazolidinediones (mTOT)-modulating insulin sensitizer and a modulator of *mitochondrial pyruvate* carrier (MPC)**. MSDC 0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities. MSDC 0160 has the potential for Alzheimer′s disease .

HY-137912

trans-Resveratrol-3-O-β-D-Glucuronide	Others	Endocrinology Cancer
trans-Resveratrol-3-O-β-D-Glucuronide is an active metabolite of trans-resveratrol. trans-Resveratrol-3-O-β-D-Glucuronide reduces the proliferation of several intestinal cancer cell line. trans-Resveratrol-3-O-β-D-Glucuronide increases pyruvate production in livers .

HY-B1142

Lipoamide 5 Publications Verification (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide	NO Synthase	Others
Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .

HY-157395

malonyl-NAC	Others	Cancer
malonyl-NAC increases cellular propylation, resulting in reduced endogenous GAPDH activity. malonyl-NAC increases GAPDH malonylation in cells and inhibits pyruvate kinase activity. In addition, malonyl-NAC limits the metabolism and proliferation of a highly glycolytic kidney cancer cell line harboring a tricarboxylic acid cycle mutation .

HY-15475

UK-5099 20+ Cited Publications PF-1005023	Mitochondrial Metabolism	Cancer
UK-5099 (PF-1005023) is a potent inhibitor of the mitochondrial pyruvate carrier (MPC). UK-5099 (PF-1005023) inhibits pyruvate-dependent O₂ consumption with an IC₅₀ of 50 nM.

HY-119874

Alkannin	Pyruvate Kinase	Inflammation/Immunology Cancer
Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin acts as a potential anticancer agent .

HY-107641

α-Cyano-4-hydroxycinnamic acid 2 Publications Verification α-Cyano-4-hydroxycinnamate	Monocarboxylate Transporter	Metabolic Disease
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a K_i of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications .

HY-142870

ZY-444

Others Cancer

ZY-444 is a small molecule that suppresses breast cancer progression by targeting pyruvate carboxylase.

ZY-444	Others	Cancer
ZY-444 is a small molecule that suppresses breast cancer progression by targeting pyruvate carboxylase.

HY-P2855

Phenylpyruvate tautomerase	Endogenous Metabolite	Metabolic Disease
Phenylpyruvate tautomerase catalyzes the interconversion of the enol and keto isomers of phenylpyruvate and (p-hydroxyphenyl)pyruvate .

HY-P2854

Alanine dehydrogenase, expressed in E. coli	Endogenous Metabolite	Metabolic Disease
Alanine dehydrogenase (EC 1.4.1.1) is a microbial enzyme that catalyzes a reversible conversion of L-alanine to pyruvate .

HY-134177

2,5-Anhydro-D-glucitol-1,6-diphosphate	Pyruvate Kinase	Metabolic Disease
2,5-Anhydro-D-glucitol-1,6-diphosphate is a limited stimulator of yeast Pyruvate Kinase. 2,5-Anhydro-D-glucitol-1,6-diphosphate is used as an analogue of the a-form, 2,5-anhydro-D-mannitol 1,6-bisphosphate, while is an excellent allosteric activator of Pyruvate Kinase .

HY-P2985

Alanine aminotransferase, Porcine heart	Endogenous Metabolite	Metabolic Disease
Alanine aminotransferase, Porcine heart is a pyridoxal enzyme that catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate .

HY-135884

Tebapivat AG-946; PKR activator 2	Pyruvate Kinase	Cardiovascular Disease
Tebapivat (PKR activator 2) is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035863A1, compound 385 .

HY-103617

PKM2-IN-1

10+ Cited Publications

Pyruvate Kinase Cancer

PKM2-IN-1 (compound 3k) is a pyruvate kinase M2 (PKM2) inhibitor with an IC₅₀ of 2.95 μM .

PKM2-IN-1 10+ Cited Publications	Pyruvate Kinase	Cancer
PKM2-IN-1 (compound 3k) is a pyruvate kinase M2 (PKM2) inhibitor with an IC₅₀ of 2.95 μM .

HY-P2807

L-Lactate dehydrogenase, Microorganism LAD	Endogenous Metabolite	Inflammation/Immunology
L-Lactate dehydrogenase, Microorganism (LAD) is a redox enzyme. L-Lactate dehydrogenase catalyzes the reduction of pyruvate to L-lactate by NADH in vivo with absolute enantiospecificity .

HY-153354

PKR activator 4	Pyruvate Kinase	Metabolic Disease
PKR activator 4 (example 7A) is a potent pyruvate kinase R (PKR) activator. PKR activator 4 has the potential for the research of blood disorders .

HY-12840

OBA-09	Reactive Oxygen Species	Neurological Disease
OBA-09, a simple ester of pyruvate and salicylic acid, is potent multi-modal neuroprotectant. OBA-09 has anti-oxidative and anti-inflammatory effects .

HY-135883

PKR activator 1

Pyruvate Kinase Cardiovascular Disease

PKR activator 1 is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035865A1, compound E7-93 .

PKR activator 1	Pyruvate Kinase	Cardiovascular Disease
PKR activator 1 is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035865A1, compound E7-93 .

HY-W005629

Leelamine	Cannabinoid Receptor PDHK	Cancer
Leelamine is a weak agonist of cannabinoid receptors CB1 and CB2. Leelamine also inhibits pyruvate dehydrogenase kinases (PDKs). Leelamine exhibits anti-tumor activity .

HY-128578

KPLH1130	PDHK	Metabolic Disease Inflammation/Immunology
KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses. KPLH1130 improves glucose tolerance in HFD-fed mice .

HY-A0231

Glymidine sodium Gondafon; Glycodiazine
Glymidine sodium is an oral active antidiabetic. Glymidine sodium is the inhibitor of hepatic lipolysis. Glymidine sodium inhibits the glucose formation and supresses the elevated pyruvate oxidation which results from the inhibition of endogenous lipid mobilization .

HY-113076S

Thiamine pyrophosphate-d3	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Thiamine pyrophosphate-d₃ is the deuterium labeled Thiamine pyrophosphate. Thiamine pyrophosphate is the coenzyme form of Vitamin B1 and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.

HY-16082

AZD7545 1 Publications Verification	PDHK	Metabolic Disease
AZD7545 is a potent, competitive, selective PDHK2 (pyruvate dehydrogenase kinase 2) inhibitor with IC₅₀s of 36.8 nM, 6.4 nM for PDHK1 and PDHK2, respectively .

HY-139573

Etavopivat FT-4202	Pyruvate Kinase	Cardiovascular Disease
Etavopivat is a potent, selective, and orally active erythrocyte pyruvate kinase (PKR) activator. Etavopivat has potent antisickling effects that can be used in studies of sickle cell disease and other haemoglobinopathies .

Cat. No.	Product Name

HY-L058

Glycolysis Compound Library

689 compounds

Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.

Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.

MCE provides a unique collection of 689 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

HY-L092

Glucose Metabolism Compound Library

1001 compounds

Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs and maintain an individual’s health. Glucose metabolism includes glycolysis, tricarboxylic acid cycle, pentose phosphate pathway, oxidative phosphorylation and other metabolic pathways. Glucose is the major carbon source that provides the main energy for life. Glucose metabolism dysregulation is also implicated in many diseases such as diabetes, heart disease, neurodegenerative diseases and even cancer.

MCE offers a unique collection of 1001 compounds related to glucose metabolism, which target glucose metabolism related targets, such as GLUT, Hexokinase, Pyruvate Kinase, IDH, etc. MCE glucose metabolism library is a powerful tool for studying glucose metabolism and drug discovery of diseases related to glucose metabolism.

HY-L133

Cuproptosis Compound Library

187 compounds

Copper is an important co-factor of all biological enzymes, but if the concentration exceeds the threshold of maintaining the homeostasis mechanism, copper will lead to cytotoxicity. This death mechanism has been named "Cuproptosis".

The mechanism of cuproptosis distinct from all other known mechanisms of regulated cell death, including apoptosis, pyroptosis, necroptosis, and ferroptosis.

Copper combine with the lipoylated components of the tricarboxylic acid cycle (TCA), leading to lipoylated protein aggregation and subsequent loss of iron-sulfur cluster proteins, ultimately resulting in protein toxicity stress and cell death. Studies have shown that the necessary factors for cuproptosis include the presence of glutathione, mitochondrial metabolism of galactose and pyruvate, and glutamine metabolism.

Targeted regulation of cuproptosis is a potential choice to treat cancer, rheumatoid arthritis, and other diseases. For example, up-regulation of LIPT1 may inhibit the occurrence and development of tumors by destroying TCA in mitochondria and then inducing cuproptosis.

MCE supplies a unique collection of 187 cuproptosis-related compounds, all of which act on the targets or signaling pathways related to cuproptosis and may have in inhibitory or activated effect on cuproptosis. MCE Cuproptosis Library is a useful tool for drug research related to cancer, rheumatoid arthritis, and other diseases.

Cat. No.	Product Name	Type

HY-D1876

ZY-2	Fluorescent Dyes/Probes
ZY-2 is a specific fluorescent probe for pyruvate kinase M2 (PKM2). ZY-2 can image in PKM2-positive cells in a time- and concentration-dependent manner. ZY-2 can be used for the detection of cancer cells .

Cat. No.	Product Name	Type

HY-W015913

Sodium 2-oxopropanoate 5 Publications Verification Sodium pyruvate	Biochemical Assay Reagents
Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .

HY-P2989

Pyruvate carboxylase	Biochemical Assay Reagents
Pyruvate carboxylase is a biotin-containing enzyme that catalyzes the HCO3 ⁻ and MgATP dependent carboxylation of pyruvate to form oxaloacetate. Pyruvate carboxylase plays an essential role in controlling whole-body energetics through regulation of gluconeogenesis in the liver, synthesis of fatty acids in adipocytes, and insulin secretion in pancreatic β cells .

HY-P2796

Pyruvate decarboxylase Kp-IpdC	Biochemical Assay Reagents
Pyruvate decarboxylase (Kp-IpdC) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P3170

*β-Alanine-pyruvate* transaminase**	Biochemical Assay Reagents
β-Alanine-pyruvate transaminase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P2876

Tryptophanase

Biochemical Assay Reagents

Tryptophanase, a bacterial enzyme, catalyzes degradation of tryptophan to indole, pyruvate and ammonia .

HY-P2977

N-Acetylneuraminate lyase (CgNal) Sialic acid aldolase (CgNal)	Biochemical Assay Reagents
N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)) is a class I aldolase, is often used in biochemical studies. N-Acetylneuraminate lyase (CgNal) catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac) .

HY-P2855

Phenylpyruvate tautomerase	Biochemical Assay Reagents
Phenylpyruvate tautomerase catalyzes the interconversion of the enol and keto isomers of phenylpyruvate and (p-hydroxyphenyl)pyruvate .

HY-128851A

Coenzyme A trilithium	Biochemical Assay Reagents
Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids .

HY-128851B

Coenzyme A sodium	Biochemical Assay Reagents
Coenzyme A (CoASH) sodium is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids .

HY-P2837

Oxaloacetate decarboxylase	Biochemical Assay Reagents
Oxaloacetate decarboxylase catalyzes the irreversible decarboxylation of oxaloacetate to pyruvate and COIC₂. Oxaloacetate decarboxylase is a member of the sodium ion transport decarboxylase (NaT-DC) enzyme family. Oxaloacetate decarboxylase converts the chemical energy of the decarboxylation reaction into an electrochemical gradient of Na ⁺ ions across the membrane .

Cat. No.	Product Name	Target	Research Area

HY-P2989

Pyruvate carboxylase	Endogenous Metabolite	Metabolic Disease
Pyruvate carboxylase is a biotin-containing enzyme that catalyzes the HCO3 ⁻ and MgATP dependent carboxylation of pyruvate to form oxaloacetate. Pyruvate carboxylase plays an essential role in controlling whole-body energetics through regulation of gluconeogenesis in the liver, synthesis of fatty acids in adipocytes, and insulin secretion in pancreatic β cells .

HY-P2796

Pyruvate decarboxylase Kp-IpdC	Peptides	Others
Pyruvate decarboxylase (Kp-IpdC) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P3170

*β-Alanine-pyruvate* transaminase**	Peptides	Others
β-Alanine-pyruvate transaminase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P2977

N-Acetylneuraminate lyase (CgNal) Sialic acid aldolase (CgNal)	Endogenous Metabolite	Others
N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)) is a class I aldolase, is often used in biochemical studies. N-Acetylneuraminate lyase (CgNal) catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac) .

HY-P2855

Phenylpyruvate tautomerase	Endogenous Metabolite	Metabolic Disease
Phenylpyruvate tautomerase catalyzes the interconversion of the enol and keto isomers of phenylpyruvate and (p-hydroxyphenyl)pyruvate .

HY-P2837

Oxaloacetate decarboxylase	Endogenous Metabolite	Metabolic Disease
Oxaloacetate decarboxylase catalyzes the irreversible decarboxylation of oxaloacetate to pyruvate and COIC₂. Oxaloacetate decarboxylase is a member of the sodium ion transport decarboxylase (NaT-DC) enzyme family. Oxaloacetate decarboxylase converts the chemical energy of the decarboxylation reaction into an electrochemical gradient of Na ⁺ ions across the membrane .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W015913

Sodium 2-oxopropanoate 5 Publications Verification Sodium pyruvate	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Reactive Oxygen Species Endogenous Metabolite
Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .

HY-B1142

Lipoamide 5 Publications Verification (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	NO Synthase
Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .

HY-113013

Hydroxypyruvic acid β-Hydroxypyruvic acid; 3-Hydroxypyruvic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Hydroxypyruvic acid (β-Hydroxypyruvic acid) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.

HY-119874

Alkannin	Quinones Structural Classification Monophenols Ohwia caudata (Thunberg) H. Ohashi Classification of Application Fields Source classification Phenols Plants Compositae Naphthalene Quinones Inflammation/Immunology Disease Research Fields	Pyruvate Kinase
Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin acts as a potential anticancer agent .

HY-113013A

Hydroxypyruvic acid lithium hydrate β-Hydroxypyruvic acid lithium hydrate; 3-Hydroxypyruvic acid lithium hydrate	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Hydroxypyruvic acid lithium hydrate (β-Hydroxypyruvic acid lithium hydrate) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid lithium hydrate is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid lithium hydrate is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.

HY-113076

Thiamine pyrophosphate	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Thiamine pyrophosphate is the coenzyme form of Vitamin B1, and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Thiamine pyrophosphate is necessary for oxidative phosphorylation and the pentose phosphate pathway by acting as a cofactor for α-ketoacid dehydrogenases .

HY-128851

Coenzyme A	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Fatty Acid Synthase (FASN) Endogenous Metabolite
Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids .

HY-126585

SAICAR 1 Publications Verification	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC₅₀ of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions .

HY-128851A

Coenzyme A trilithium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Fatty Acid Synthase (FASN)
Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids .

HY-128851B

Coenzyme A sodium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Fatty Acid Synthase (FASN)
Coenzyme A (CoASH) sodium is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids .

HY-N12016

Fulvotomentoside B	Triterpenes Structural Classification Caprifoliaceae Terpenoids Source classification Plants Lonicera macrantha (D. Don) Spreng. Saccharides Monosaccharides	Others
Fulvotomentoside B is a saponin isolated from Lactobacillus flavus. Fulvotomentoside compounds can significantly reduce serum glutamate pyruvate transaminase (SGPT) and triacylglycerol (GT) levels in mice poisoned by CCl₄, d-galactosamine (d-gal) and acetaminophen, and significantly alleviate liver pathology. damage .

HY-112948

2-Methylbutyrylcarnitine	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2-Methylbutyrylcarnitine is a fatty acid metabolite. 2-Methylbutyrylcarnitine is found mainly in the blood and urine of humans and animals and is produced through the pyruvate carboxylation pathway. 2-Methylbutyrylcarnitine exhibits high level in the plasma of subjects with steatohepatitis (NASH) and can be used as an indicator for the diagnosis of metabolic diseases .

HY-N0822

Shikonin Maximum Cited Publications 31 Publications Verification C.I. 75535; Isoarnebin 4	Quinones Structural Classification Classification of Application Fields Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Disease Research Fields Boraginaceae Cancer	Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits AIM2 inflammasome activation .

Species:	Human (7) Rat (1) Mouse (5) E.coli (1)
Tag:	SUMO (1) His (13) Myc (1) GST (2)
Source:	HEK293 (2) P. pastoris (1) Sf9 insect cells (5) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P71210

	PKLR Protein, Human (HEK293, His) pyruvate Kinase Isozymes R/L; pyruvate Kinase 1; R-Type/L-Type pyruvate Kinase; Red Cell/Liver pyruvate Kinase; PKLR; PK1; PKL	Human	HEK293
	The PKLR protein is a key enzyme in cellular metabolism that acts as a pyruvate kinase, converting phosphoenolpyruvate to pyruvate. This process is an integral part of glycolysis, the fundamental pathway for cellular energy production. PKLR Protein, Human (HEK293, His) is the recombinant human-derived PKLR protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PKLR Protein, Human (HEK293, His) is 574 a.a., with molecular weight of ~62.0 kDa.

HY-P71458

	PpsA Protein, E.coli (His-SUMO) ppsA; pps; b1702; JW1692Phosphoenolpyruvate synthase; PEP synthase; EC 2.7.9.2; pyruvate; water dikinase	E.coli	E. coli
	The PpsA protein plays a crucial role in cellular metabolism by catalyzing the conversion of pyruvate to phosphoenolpyruvate, a key step in glycolysis and gluconeogenesis. This enzyme activity is the basis for the interconversion of metabolic intermediates and contributes to the regulation of intracellular energy production and utilization. PpsA Protein, E.coli (His-SUMO) is the recombinant E. coli-derived PpsA protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of PpsA Protein, E.coli (His-SUMO) is 791 a.a., with molecular weight of ~103.3 kDa.

HY-P700578

	PKLR Protein, Rat (P. pastoris, His) PKLR; pyruvate kinase, liver and RBC; PK1; PKL; PKR; RPK; PKRL; pyruvate kinase isozymes R/L; pyruvate kinase 1; OTTHUMP00000034069; pyruvate kinase type L; pyruvate kinase isozyme R/L; R-type/L-type pyruvate kinase; red cell/liver pyruvate kinase; pyruvate kinase, liver and blood cell; EC 2.7.1.40	Rat	P. pastoris
	PKLR Protein, a pyruvate kinase, plays a crucial role in glycolysis, converting phosphoenolpyruvate to pyruvate and generating ATP. As a key enzyme, PKLR mediates the final steps of glycolysis, contributing to energy production. Its catalytic activity influences pyruvate, a central metabolite with implications for cellular processes, including energy metabolism and the tricarboxylic acid (TCA) cycle. PKLR's significance in glycolytic flux underscores its essential role in cellular energy homeostasis, presenting potential for therapeutic interventions in metabolic pathways. PKLR Protein, Rat (P. pastoris, His) is the recombinant rat-derived PKLR protein, expressed by P. pastoris, with N-6*His labeled tag. The total length of PKLR Protein, Rat (P. pastoris, His) is 574 a.a., with molecular weight of 64.2 kDa.

HY-P701737

	PDK4 Protein, Human (GST) PDK4; [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4; mitochondrial; pyruvate dehydrogenase kinase isoform 4	Human	E. coli
	PDK4 Protein phosphorylates PDHA1 and PDHA2, inhibiting pyruvate dehydrogenase activity. This reduces glucose utilization, enhances fat metabolism, and helps maintain blood glucose levels during fasting. PDK4 also regulates fatty acid oxidation and biosynthesis, generates reactive oxygen species, protects epithelial cells, and regulates cell proliferation through metabolic regulation. PDK4 Protein, Human (GST) is the recombinant human-derived PDK4 protein, expressed by E. coli , with N-GST labeled tag. The total length of PDK4 Protein, Human (GST) is 411 a.a., .

HY-P71676

	PDCE2 Protein, Mouse (HEK293, His) Dlat; Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2	Mouse	HEK293
	PDCE2 Protein, a vital element in the pyruvate dehydrogenase complex, is integral to cellular metabolism. It catalyzes the conversion of pyruvate to acetyl-CoA and CO2, connecting glycolysis to the tricarboxylic acid (TCA) cycle. PDCE2's catalytic function is essential for efficient pyruvate utilization, ensuring the flow of carbon compounds through key metabolic pathways crucial for energy production and cellular homeostasis. PDCE2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived PDCE2 protein, expressed by HEK293 , with N-10*His labeled tag. The total length of PDCE2 Protein, Mouse (HEK293, His) is 557 a.a., with molecular weight of 75-95 kDa.

HY-P71614

	PDK3 Protein, Mouse (His) Pdk3; pyruvate dehydrogenase kinase isoform 3	Mouse	E. coli
	PDK3 is a metabolic regulator that inhibits pyruvate dehydrogenase through PDHA1 phosphorylation to fine-tune glucose metabolism and affect aerobic respiration. Phosphorylation of PDHA2 adds another layer of control. PDK3 Protein, Mouse (His) is the recombinant mouse-derived PDK3 protein, expressed by E. coli , with N-His labeled tag. The total length of PDK3 Protein, Mouse (His) is 232 a.a., with molecular weight of ~30.3 kDa.

HY-P70599

	PKM2 Protein, Human (530a.a, His) pyruvate kinase PKM; CTHBP; OIP-3; THBP1	Human	E. coli
	PKM2 Protein, Human (530a.a, His) is a recombinant PKM2 protein with a His-Flag. PKM2 Protein is one of the rate-limiting enzymes in glycolysis.

HY-P73718

	PDK1 Protein, Human (sf9, His) pyruvate dehydrogenase kinase isoform 1; PDK1; PDHK1	Human	Sf9 insect cells
	PDK1 protein is a key kinase that controls glucose and fatty acid metabolism by phosphorylating pyruvate dehydrogenase subunits PDHA1 and PDHA2. This molecular switch inhibits pyruvate dehydrogenase, fine-tunes metabolite flux and downregulates aerobic respiration. PDK1 Protein, Human (sf9, His) is the recombinant human-derived PDK1 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of PDK1 Protein, Human (sf9, His) is 408 a.a., with molecular weight of ~45 kDa.

HY-P74629

	PKM2 Protein, Mouse (sf9, His) pyruvate Kinase M2; PKM2; CTHBP; OIP-3; THBP1	Mouse	Sf9 insect cells
	PKM2 protein catalyzes the final step of glycolysis, transferring a phosphoryl group from PEP to ADP to generate ATP. In the nucleus, transcriptional activation of PKM2 contributes to cancer progression, promoting cell proliferation and tumorigenesis. PKM2 is also involved in caspase-independent cell death in tumors. PKM2 Protein, Mouse (sf9, His) is the recombinant mouse-derived PKM2 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of PKM2 Protein, Mouse (sf9, His) is 530 a.a., with molecular weight of ~59 kDa.

HY-P75286

	DLAT Protein, Human (sf9, His) pyruvate dehydrogenase complex component E2; PBC; PDC-E2; DLAT; DLTA	Human	Sf9 insect cells
	DLAT protein is an important component of the pyruvate dehydrogenase complex, which mainly promotes the conversion of pyruvate into acetyl-CoA and CO2. This enzymatic step establishes a critical link between glycolysis and the tricarboxylic acid (TCA) cycle. DLAT Protein, Human (sf9, His) is the recombinant human-derived DLAT protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of DLAT Protein, Human (sf9, His) is 561 a.a., with molecular weight of ~62.1 kDa.

HY-P74639

	PDK4 Protein, Mouse (sf9, His-GST) pyruvate dehydrogenase kinase isoform 4; PDK4; PDHK4	Mouse	Sf9 insect cells
	PDK4 protein is a key kinase that regulates glucose and fatty acid metabolism by phosphorylating pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, modulates metabolite flux and inhibits aerobic respiration. PDK4 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived PDK4 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of PDK4 Protein, Mouse (sf9, His-GST) is 412 a.a., with molecular weight of ~65 kDa.

HY-P72053

	PKM2 Protein, Mouse (Baculovirus, His-Myc) Pkm; Pk3; Pkm2; Pykmpyruvate kinase PKM; EC 2.7.1.40; pyruvate kinase muscle isozyme	Mouse	Sf9 insect cells
	PKM2 protein catalyzes the final step of glycolysis, transferring a phosphoryl group from PEP to ADP to generate ATP. In the nucleus, transcriptional activation of PKM2 contributes to cancer progression, promoting cell proliferation and tumorigenesis. PKM2 is also involved in caspase-independent cell death in tumors. PKM2 Protein, Mouse (Baculovirus, His-Myc) is the recombinant mouse-derived PKM2 protein, expressed by Sf9 insect cells , with N-10*His, C-Myc labeled tag. The total length of PKM2 Protein, Mouse (Baculovirus, His-Myc) is 531 a.a., with molecular weight of ~61.8 kDa.

HY-P7803

	PKM2 Protein, Human (420 a.a, His) rHupyruvate Kinase M2/PKM2, His; pyruvate Kinase M2; PKM2; CTHBP; OIP-3; THBP1	Human	E. coli
	PKM2 Protein, Human (420 a.a, His) is a multifunctional protein, is exclusively expressed in embryonic and adult dividing/tumor cells. PKM2 can catabolize glucose and involved in many nonglycolytic pathways.

HY-P702494

	GPT1 Protein, Human (His) AAT1; Alanine aminotransferase 1; Alanine aminotransferase; ALAT1_HUMAN; ALT1; Glutamate pyruvate transaminase 1; Glutamic alanine transaminase 1; Glutamic pyruvate transaminase (alanine aminotransferase); Glutamic pyruvic transaminase 1; Glutamic--alanine transaminase 1; Glutamic--pyruvic transaminase 1; GPT 1; gpt; GPT1	Human	E. coli
	The GPT1 protein is a key player that catalyzes the reversible cleavage of L-arginine succinate, which is critical in the urea cycle, aids in hepatic nitrogen detoxification and promotes de novo L-arginine synthesis. GPT1 regulates intracellular and extracellular L-arginine pools, which are critical for nitrogen homeostasis. GPT1 Protein, Human (His) is the recombinant human-derived GPT1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of GPT1 Protein, Human (His) is 495 a.a., with molecular weight of 58.5 kDa.

Cat. No.	Product Name	Chemical Structure

HY-W015913S

Sodium 2-oxopropanoate-13C3
Sodium 2-oxopropanoate- ¹³C₃ is the ¹³C-labeled Sodium 2-oxopropanoate. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[1][2].

HY-Y1362S

*Ethyl pyruvate-d3*
Ethyl pyruvate-d₃ is the deuterium labeled Ethyl pyruvate[1]. Ethyl pyruvate is a simple derivative of the endogenous metabolite, pyruvic acid. Ethyl pyruvate is an anti-inflammatory agent[2].

HY-W016203S

Sodium Phenyl-d5-pyruvate

Sodium Phenyl-d₅-pyruvate is the deuterium labeled Sodium Phenyl-pyruvate[1].

HY-W015913S1

Sodium 2-oxopropanoate-d3
Sodium 2-oxopropanoate-d₃ is the deuterium labeled Sodium 2-oxopropanoate[1]. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[2][3].

HY-113076S

Thiamine pyrophosphate-d3
Thiamine pyrophosphate-d₃ is the deuterium labeled Thiamine pyrophosphate. Thiamine pyrophosphate is the coenzyme form of Vitamin B1 and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.

HY-W015913S3

Sodium 2-oxopropanoate-13C
Sodium 2-oxopropanoate- ¹³C is the ¹³C labeled Sodium 2-oxopropanoate[1]. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[2][3].

HY-W015913S4

2-Oxopropanoate-13c2 sodium
2-Oxopropanoate- ¹³C₅ (sodium) is the ¹³C labeled Sodium 2-oxopropanoate[1]. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[2][3].

HY-126585S

SAICAR-d1
SAICAR-d is the deuterium labeled SAICAR. SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC50 of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions[1][2].

Cat. No.	Product Name	Application	Reactivity

HY-P80292

Pyruvate Dehydrogenase E2 Antibody	WB, IHC-P	Human, Mouse, Rat
Pyruvate Dehydrogenase E2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 69 kDa, targeting to Pyruvate Dehydrogenase E2. It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P83643

Phospho-PKM2(Tyr148)Antibody PKM2 (Phospho Tyr148); PKM2 (Phospho Y148); PK 1; PK 2; PK 3; PK Muscle type; PK1; PK2; Pk3; PKL; PKLR; PKM 2; PKM; PYKM; pyruvate kinase 1; pyruvate kinase 2/3; pyruvate kinase 3; pyruvate kinase isozyme R/L; pyruvate kinase isozymes M1/M2; pyruvate kinase liver and blood cell; pyruvate kinase liver and RBC; pyruvate kinase liver and RBC type; pyruvate kinase M2; pyruvate kinase muscle; pyruvate kinase muscle isozyme; pyruvate kinase type L; R type/L type pyruvate kinase; Red cell/liver pyruvate kinase; RPK; TCB; THBP 1; THBP1; Thyroid hormone binding protein cytosolic; CTHBP; Cytosolic thyroid hormone binding protein; MGC3932; OIP 3; Oip3; Tumor M2-PK; p58; OIP-3; KPYM_HUMAN.	WB, IHC-P, IHC-F, ICC, IF, Flow-Cyt, ELISA	Human (predicted: Mouse, Rat, Pig, Cow, Rabbit, Sheep, GuineaPig)

HY-P83644

Phospho-PKM2(Tyr105)Antibody PKM2 (Phospho Tyr105); PKM2 (Phospho Y105); PK 1; PK 2; PK 3; PK Muscle type; PK1; PK2; Pk3; PKL; PKLR; PKM 2; PKM; PYKM; pyruvate kinase 1; pyruvate kinase 2/3; pyruvate kinase 3; pyruvate kinase isozyme R/L; pyruvate kinase isozymes M1/M2; pyruvate kinase liver and blood cell; pyruvate kinase liver and RBC; pyruvate kinase liver and RBC type; pyruvate kinase M2; pyruvate kinase muscle; pyruvate kinase muscle isozyme; pyruvate kinase type L; R type/L type pyruvate kinase; Red cell/liver pyruvate kinase; RPK; TCB; THBP 1; THBP1; Thyroid hormone binding protein cytosolic; CTHBP; Cytosolic thyroid hormone binding protein; MGC3932; OIP 3; Oip3; Tumor M2-PK; p58; OIP-3.	IHC-P, IHC-F, IF, Flow-Cyt, ELISA	Human, Rat (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, GuineaPig)

HY-P80291

Pyruvate Dehydrogenase E1 beta subunit Antibody	WB, IHC-P, FC, IP	Human, Mouse, Rat
Pyruvate Dehydrogenase E1 beta subunit Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 39 kDa, targeting to Pyruvate Dehydrogenase E1 beta subunit. It can be used for WB,IHC-P,FC,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80878

Pyruvate Dehydrogenase E1 alpha Antibody (YA681) mitochondrial; ODPA_HUMAN; PDH; PDHA; PDHA1; PDHCE1A; PDHE1 A type I; PDHE1-A type I; PHE1A; pyruvate Dehydrogenase (lipoamide) alpha 1; pyruvate dehydrogenase complex; E1 alpha polypeptide 1; pyruvate Dehydrogenase E1 alpha; pyruvate dehydrogenase E1 com	WB, ICC/IF	Human, Mouse
Pyruvate Dehydrogenase E1 alpha Antibody (YA681) is a non-conjugated and Mouse origined monoclonal antibody about 43 kDa, targeting to Pyruvate Dehydrogenase E1 alpha (3H2). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse.

HY-P81650

PDK2 Antibody (YA1395)

PDK2; PDHK2; [pyruvate dehydrogenase [lipoamide]] kinase isozyme 2; mitochondrial; pyruvate dehydrogenase kinase isoform 2
WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P82315

PCB Antibody (YA2060)

PC; pyruvate carboxylase; mitochondrial; Pyruvic carboxylase; PCB
WB, ICC/IF Human, Mouse, Rat

HY-P80870

PKM2 Antibody PKM; OIP3; PK2; PK3; PKM2; pyruvate kinase isozymes M1/M2; Cytosolic thyroid hormone-binding protein; CTHBP; Opa-interacting protein 3; OIP-3; pyruvate kinase 2/3; pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; THBP1; Tu	WB	Human, Mouse, Rat, Monkey
PKM2 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 58 kDa, targeting to PKM2. It can be used for WB assays with tag free, in the background of Human, Mouse, Rat, Monkey.

HY-P81070

DLAT Antibody (YA912) DLAT; DLTA; E2; PBC; PDCE2; pyruvate Dehydrogenase E2	WB, ICC/IF, IP	Human, Mouse
DLAT Antibody (YA912) is an unconjugated, approximately 69 kDa, mouse-derived, anti-DLAT (YA912) monoclonal antibody. DLAT Antibody (YA912) can be used for: WB, ICC/IF, IP expriments in human, mouse background without labeling.

HY-P82629

Pyruvate Dehydrogenase E1 beta Antibody (YA2374)

pdhB; DHBD; PDHE1 B; PDHE1-B; PHE1B
WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat


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pyruvate

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