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racemate

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By Targets:	11β-HSD (1) Acyltransferase (1) Amino Acid Derivatives (1) Apoptosis (2) CFTR (1) COX (2) EGFR (1) Endogenous Metabolite (2) GSK-3 (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Lactate Dehydrogenase (1) mAChR (1) Molecular Glues (1) nAChR (2) Serotonin Transporter (1) Sodium Channel (1) VEGFR (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (5) Metabolic Disease (5) Neurological Disease (9)
Click Chemistry:	Azide (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124540B

(Rac)-ABT-202 dihydrochloride	nAChR	Neurological Disease
(Rac)-ABT-202 dihydrochloride is a racemate of ABT-202. ABT-202 is an agonist of nicotinic acetylcholine receptors (nAChRs) and can be used as an analgesic .

HY-15029

(±)-Naproxen (Rac)-Naproxen	COX	Inflammation/Immunology Cancer
(±)-Naproxen ((Rac)-Naproxen) is a racemate of Naproxen (HY-15030). Naproxen is a COX-1 and COX-2 inhibitor with IC₅₀s of 8.72 and 5.15 μM, respectively.

HY-104065A

(Rac)-Pyrotinib

(Rac)-SHR-1258
Others Cancer

(Rac)-Pyrotinib ((Rac)-SHR-1258) is the racemate of Pyrotinib (HY-104065). Pyrotinib is a potent and selective EGFR/HER2 dual inhibitor.

(Rac)-Pyrotinib (Rac)-SHR-1258	Others	Cancer
(Rac)-Pyrotinib ((Rac)-SHR-1258) is the racemate of Pyrotinib (HY-104065). Pyrotinib is a potent and selective EGFR/HER2 dual inhibitor.

HY-116830A

(Rac)-BRD0705	GSK-3	Cancer
(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC₅₀ of 66 nM and a K_d of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC₅₀ of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML) .

HY-15846A

(Rac)-CPI-203

Others Cancer

(Rac)-CPI-203 is a racemate of CPI-203 (HY-15846) (BET bromodomain inhibitor)

(Rac)-CPI-203	Others	Cancer
(Rac)-CPI-203 is a racemate of CPI-203 (HY-15846) (BET bromodomain inhibitor)

HY-N0075

(Rac)-Byakangelicin	Others	Metabolic Disease
(Rac)-Byakangelicin is a racemate of Byakangelicin mainly isolated from the genus Angelica. Byakangelicin is an aldose-reductase inhibitor with an IC₅₀ value of 6.2 μM .

HY-111540A

(Rac)-LY-3381916 (Rac)-IDO1-IN-5	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
(Rac)-LY-3381916 ((Rac)-IDO1-IN-5; Example 1) is a racemate of LY-3381916 . LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 .

HY-119738A

(Rac)-OSMI-1	Acyltransferase	Metabolic Disease
(Rac)-OSMI-1 is the racemate of OSMI-1. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC₅₀ value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .

HY-117526

(-)-Mesembrine

Endogenous Metabolite Neurological Disease

(-)-Mesembrine, a psychoactive alkaloid, is a partial racemate in S. strictum and S. tortuosum in smaller amounts .
HY-50722A

(Rac)-NNC 55-0396

Others Neurological Disease

(Rac)-NNC 55-0396 is the racemate of NNC 55-0396 (HY-50722) .

(-)-Mesembrine	Endogenous Metabolite	Neurological Disease
(-)-Mesembrine, a psychoactive alkaloid, is a partial racemate in S. strictum and S. tortuosum in smaller amounts .

(Rac)-NNC 55-0396	Others	Neurological Disease
(Rac)-NNC 55-0396 is the racemate of NNC 55-0396 (HY-50722) .

HY-W011303A

(Rac)-Phytosphingosine (Rac)-4-Hydroxysphinganine	Others	Others
(Rac)-Phytosphingosine ((Rac)-4-Hydroxysphinganine) is the racemate of Phytosphingosine (HY-W011303). Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

HY-103700B

(Rac)-Azide-phenylalanine	Amino Acid Derivatives	Others
(Rac)-Azide-phenylalanine is a racemate of Azide-phenylalanine. Azide-phenylalanine is a phenylalanine derivative and a non-natural amino acid. Azide-phenylalanine can be site-specifically incorporated into proteins and used to label proteins . (Rac)-Azide-phenylalanine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-123050

(Rac)-SAR131675

VEGFR Neurological Disease

(Rac)-SAR131675 is the racemate of SAR131675. SAR131675 is a potent and selective VEGFR3 inhibitor with an IC₅₀ of 23 nM .

(Rac)-SAR131675	VEGFR	Neurological Disease
(Rac)-SAR131675 is the racemate of SAR131675. SAR131675 is a potent and selective VEGFR3 inhibitor with an IC₅₀ of 23 nM .

HY-139126

(±)-Muscarine chloride DL-Muscarin chloride	mAChR	Neurological Disease
(±)-Muscarine chloride is the racemate of Muscarine chloride. Muscarine is a prototype muscarinic acetylcholine receptor agonist .

HY-15448A

(Rac)-Tezacaftor (Rac)-VX-661	CFTR	Inflammation/Immunology
(Rac)-Tezacaftor ((Rac)-VX-661) is a racemate of Tezacaftor (HY-15448). Tezacaftor is a F508del CFTR corrector. (Rac)-Tezacaftor can be used for the research of cystic fibrosis .

HY-135805A

(Rac)-JBJ-04-125-02

EGFR Cancer

(Rac)-JBJ-04-125-02 is the racemate of JBJ-04-125-02. JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor .

(Rac)-JBJ-04-125-02	EGFR	Cancer
(Rac)-JBJ-04-125-02 is the racemate of JBJ-04-125-02. JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor .

HY-101930A

(Rac)-BMS-816336	11β-HSD	Metabolic Disease
(Rac)-BMS-816336 (Compound 6n) is a racemate of BMS-816336. (Rac)-BMS-816336 is a potent inhibitor of human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC₅₀s of 10 nM and 68 nM, respectively. (Rac)-BMS-816336 has good metabolic stability .

HY-108695B

(±)-Enterodiol	Apoptosis Endogenous Metabolite	Cancer
(±)-Enterodiol is the racemate of Enterodiol (HY-108695). Enterodiol is transformed by human intestinal bacteria from lignans contained in various whole-grain cereals, nuts, legumes, flaxseed, and vegetables. Enterodiol has an apoptotic effect in colorectal cancer (CRC) cells. Enterodiol has anti-cancer activities .

HY-100742

GNE-140 racemate 5 Publications Verification	Lactate Dehydrogenase	Cancer
GNE-140 racemate is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor .

HY-14658B

(R)-Thalidomide (R)-(+)-Thalidomide	Others	Metabolic Disease
(R)-Thalidomide ((R)-(+)-Thalidomide) is the R-enantiomer of Thalidomide. (R)-Thalidomide has psychomotor stabilizing properties .

HY-138879A

(Rac)-CP-601927 hydrochloride	nAChR	Neurological Disease
(Rac)-CP-601927 hydrochloride is the racemate of CP-601927. CP-601927 is a nAChR agonist with Ki values 1.2 nM and 102 nM for α4β2 and α3β4 nAChR, respectively .

HY-B0161E

(±)-Duloxetine hydrochloride (Rac)-Duloxetine hydrochloride	Serotonin Transporter	Neurological Disease
(±)-Duloxetine ((Rac)-Duloxetine) hydrochloride is the racemate of Duloxetine hydrochloride. Duloxetine hydrochloride, a serotonin-norepinephrine reuptake inhibitor, can be used for diabetic neuropathic pain and fibromyalgia as well as major depressive disorder research .

HY-131670

(±)9,10-DiHOME	Others	Inflammation/Immunology
(±)9,10-DiHOME is the racemate of 9,10-DiHOME. 9,10-DiHOME is a leukotoxin derivative of linoleic acid diol that has been reported to be toxic in human's tissue preparations, and is produced by inflammatory leukocytes such as neutrophils and macrophages .

HY-14658A

(S)-Thalidomide (S)-(-)-Thalidomide	Apoptosis Molecular Glues	Metabolic Disease Inflammation/Immunology
(S)-Thalidomide ((S)-(-)-Thalidomide) is the S-enantiomer of Thalidomide. (S)-Thalidomide has immunomodulatory, anti-inflammatory, antiangiogenic and pro-apoptotic effects . (S)-Thalidomide induces teratogenic effects by binding to cereblon (CRBN) .

HY-108425B

(Rac)-AMG8379 (Rac)-AMG8380	Sodium Channel	Neurological Disease
(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. AMG8379 is a potent, orally active and selective sulfonamide antagonist of NaV1.7, with IC₅₀s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively .

HY-B1890

(±)-Catechin 1 Publications Verification rel-Cianidanol; rel-Catechuic acid	COX	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
(±)-Catechin (rel-Cianidanol) This is a green tea polyester. Catechin possesses anti-cancer activity, which has led to its demise. (±)-Catechin 具有两种forms (+)-Catechin and its reflection body (-)-Catechin. (+)-Catechin inhibitory environment-1 (COX-1) IC₅₀ 为 1.4 μM. (-)-Catechin has the effect of promoting hBM-MSC adipose cell differentiation, increasing adipose tissue, and PPARγ horizontal. (±)-Catechin has anti-diabetic, anti-hypertrophic, anti-diabetic, anti-cardiovascular, anti-infective, and liver-protecting effects.

(Rac)-Byakangelicin	Classification of Application Fields Source classification Ruta graveolens Linn. Rutaceae Coumarins Metabolic Disease Phenylpropanoids Plants Disease Research Fields	Others
(Rac)-Byakangelicin is a racemate of Byakangelicin mainly isolated from the genus Angelica. Byakangelicin is an aldose-reductase inhibitor with an IC₅₀ value of 6.2 μM .

(±)-Catechin 1 Publications Verification rel-Cianidanol; rel-Catechuic acid	Cardiovascular Disease Structural Classification Neurological Disease Classification of Application Fields Source classification Plants Camellia sinensis (L.) O. Ktze. Infection Phenols Polyphenols Inflammation/Immunology Disease Research Fields Theaceae	COX
(±)-Catechin (rel-Cianidanol) This is a green tea polyester. Catechin possesses anti-cancer activity, which has led to its demise. (±)-Catechin 具有两种forms (+)-Catechin and its reflection body (-)-Catechin. (+)-Catechin inhibitory environment-1 (COX-1) IC₅₀ 为 1.4 μM. (-)-Catechin has the effect of promoting hBM-MSC adipose cell differentiation, increasing adipose tissue, and PPARγ horizontal. (±)-Catechin has anti-diabetic, anti-hypertrophic, anti-diabetic, anti-cardiovascular, anti-infective, and liver-protecting effects.

(-)-Mesembrine	Alkaloids Source classification Aizoaceae Mesembryanthemum tortuosum Plants Indole Alkaloids	Endogenous Metabolite
(-)-Mesembrine, a psychoactive alkaloid, is a partial racemate in S. strictum and S. tortuosum in smaller amounts .

(Rac)-Phytosphingosine (Rac)-4-Hydroxysphinganine	Structural Classification Natural Products other families Source classification Plants	Others
(Rac)-Phytosphingosine ((Rac)-4-Hydroxysphinganine) is the racemate of Phytosphingosine (HY-W011303). Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

(±)-Enterodiol	Structural Classification Source classification Phenols Polyphenols Endogenous metabolite	Apoptosis Endogenous Metabolite
(±)-Enterodiol is the racemate of Enterodiol (HY-108695). Enterodiol is transformed by human intestinal bacteria from lignans contained in various whole-grain cereals, nuts, legumes, flaxseed, and vegetables. Enterodiol has an apoptotic effect in colorectal cancer (CRC) cells. Enterodiol has anti-cancer activities .

(Rac)-Azide-phenylalanine		Azide
(Rac)-Azide-phenylalanine is a racemate of Azide-phenylalanine. Azide-phenylalanine is a phenylalanine derivative and a non-natural amino acid. Azide-phenylalanine can be site-specifically incorporated into proteins and used to label proteins . (Rac)-Azide-phenylalanine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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racemate

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