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Results for "

receptor-related

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ROR (12) 5-HT Receptor (1) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (2) Autophagy (1) Reactive Oxygen Species (1) Thyroid Hormone Receptor (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Endocrinology (2) Inflammation/Immunology (9) Neurological Disease (3)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Targets Recommended: Interleukin Related Mas-related G-protein-coupled Receptor (MRGPR) Trk Receptor ROR NEKs Kallikrein Atg4 CGRP Receptor Atg8/LC3 Arp2/3 Complex ATM/ATR sFRP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-133552

RORγt Inverse agonist 10	ROR	Inflammation/Immunology
RORγt Inverse agonist 10 is a potent and orally bioavailable *RORγt (retinoic acid receptor-related* orphan nuclear receptor gamma t) inverse agonist, with an IC₅₀** of 51 nM. RORγt is a major transcription factor of genes related to psoriasis pathogenesis such as IL-17A, IL-22, and IL-23R

HY-119366

S18-000003	ROR	Inflammation/Immunology
S18-000003 is a potent, selective and orally active inhibitor of *retinoic acid receptor-related* orphan receptor-gamma-t (RORγt), with an IC₅₀** of <30 nM towards human RORγt in competitive binding assays. S18-000003 shows selectivity for RORγt over other ROR family members (IC₅₀>10 μM). S18-000003 can be used for the research of psoriasis with low risk of thymic aberrations .

HY-139847

RORγt inverse agonist 23	ROR	Inflammation/Immunology
RORγt inverse agonist 23 is a potent, selective, and orally available novel *retinoic acid receptor-related* orphan receptor γt** inverse agonist.

HY-112706

PF-06747711	ROR	Inflammation/Immunology
PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC₅₀ of 4.1 nM. Anti-skin inflammatory activity .

HY-128353

ROR agonist-1	ROR	Inflammation/Immunology
ROR agonist-1 is a potent and orally bioavailable inverse agonist of the *retinoic acid receptor-related* orphan receptor C2 (RORC2)**, inhibition of IL-17A production from human primary T_H 17 cells with a pIC₅₀ of 7.5 .

HY-133128

FM26	ROR	Cancer
FM26 (compound 25) is a potent and allosteric *retinoic acid receptor-related* orphan receptor γt (RORγt) inverse agonists with an IC₅₀** of 264 nM. FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells .

HY-119464

MRL-871 1 Publications Verification	ROR	Cancer
MRL-871 (compound 3) is a potent and allosteric *retinoic acid receptor-related* orphan receptor γt (RORγt) inverse agonists with an IC₅₀** of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells .

HY-155548

RORγt inverse agonist 31	ROR	Inflammation/Immunology
RORγt inverse agonist 31 (14g) is a potent *retinoic acid receptor-related* orphan receptor γt (RORγt) inverse agonist, with an IC₅₀** of 0.428 μM. RORγt inverse agonist 31 can alleviate the severity of Imiquimod (HY-B0180)-induced psoriasis in mice .

HY-14422

SR1078 10+ Cited Publications	ROR	Cancer
SR1078 is a selective agonist of retinoic acid receptor-related orphan receptor α/γ (RORα/RORγ). SR1078 directly binds to the ligand binding domain of RORα and RORγ and increases the transcriptional activity of these receptors, leading to stimulation of RORα/γ target gene transcription .

HY-120785

SR1555	ROR	Inflammation/Immunology
SR1555 is a specific *retinoic acid receptor-related* orphan nuclear receptor γ (RORγ) inverse agonist with an IC₅₀** value of 1 μM. SR1555 not only inhibits TH17 cell development and function but also increases the frequency of T regulatory cells, as well as inhibits the expression of IL-17. SR1555 can be used for researching autoimmune diseases .

HY-142441

THR-β agonist 1	Others	Endocrinology
THR-β Agonist 1 is a potent and selective agonist of THRβ. Thyroid hormone receptor mediates the physiological activity of thyroid hormones which plays a key role in normal growth and development of the body and in maintaining metabolic balance. THR-β Agonist 1 has the potential for the research of thyroid hormone receptor-related diseases (extracted from patent WO2021104288A1, compound 2) .

HY-N0155

Nobiletin Maximum Cited Publications 16 Publications Verification	ROR Reactive Oxygen Species Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Cancer
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a *retinoid acid receptor-related* orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis** .

HY-122816

HLY78 5+ Cited Publications	Wnt β-catenin Apoptosis	Cardiovascular Disease Neurological Disease Cancer
HLY78, a Lycorine (HY-N0288) derivative, is a potent activator of the Wnt/β-catenin signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylation and Wnt signal transduction. HLY78 can be used for subarachnoid hemorrhage (SAH) research .

HY-P4073

ANG1005 GRN1005; Paclitaxel trevatide	Antibody-Drug Conjugates (ADCs)	Cancer
ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system .

HY-111509

TAK-828F	ROR	Inflammation/Immunology
TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (binding IC₅₀=1.9 nM, reporter gene IC₅₀=6.1 nM). TAK-828F shows excellent RORγt isoforms selectivity (>5000-fold selectivity against human RORα and RORβ) .

HY-153637

THR-β modulator-1	Thyroid Hormone Receptor	Endocrinology
THR-β modulator-1 (compound 1a) is a potent *thyroid hormone receptor* β** modulator. THR-β modulator-1 can be used in research of thyroid hormone receptor related disorders .

HY-109527

5-HT7 agonist 1	5-HT Receptor	Neurological Disease
5-HT7 agonist 1 is a selective 5-HT7 receptor agonist, with an IC₅₀ of 222.93 nM, can be used for the 5-HT7 receptor related disease, such as CNS disorders.

HY-101060

FGIN 1-43
FGIN 1-43 is an effective and specific ligand for the mitochondrial diazepam binding inhibitor (DBI) receptor (related to the production of neurosteroids). FGIN 1-43 enhances the transmission of GABA by inducing the production of neurosteroids, which can be used for research on anti-anxiety .

HY-100047

Nα,Nα-Bis(carboxymethyl)-L-lysine
Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of *bitter taste receptor* 4, with an IC₅₀** of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study .

Cat. No.	Product Name

HY-L165

*Dopamine Receptor* Compound Library**	195 compounds
Dopamine receptor (DAR), widely distributed in the brain, plays a key role in regulating motor function, motivation, driving force and cognition. The role of DA is mediated by D1-type (D1, D5) and D2-type receptors (D2S, D2L, D3, D4), which are distributed in presynaptic, postsynaptic and extrasynaptic, projection neurons and interneurons. Each receptor has a different function. D1 and D5 receptors couple with G stimulation sites and activate Adenylyl cyclase. The activation of Adenylyl cyclase leads to the production of the second messenger cAMP, which leads to the production of protein kinase A (PKA), which leads to further transcription in the nucleus. D2 to D4 receptors are coupled to G inhibitory sites to inhibit adenylyl cyclase and activate potassium Ion channel. These receptors utilize phosphorylation cascades or direct membrane interactions to affect the functions of voltage-gated and neurotransmitter-gated channels, cytoplasmic enzymes, and transcription factors. Dopamine receptor plays an important role in daily life. MCE designs a unique collection of 195 small molecules related to dopamine receptor. It is a good tool for screening drugs from nervous system disease.

Dopamine Receptor Compound Library

195 compounds

Dopamine receptor (DAR), widely distributed in the brain, plays a key role in regulating motor function, motivation, driving force and cognition. The role of DA is mediated by D1-type (D1, D5) and D2-type receptors (D2S, D2L, D3, D4), which are distributed in presynaptic, postsynaptic and extrasynaptic, projection neurons and interneurons. Each receptor has a different function. D1 and D5 receptors couple with G stimulation sites and activate Adenylyl cyclase. The activation of Adenylyl cyclase leads to the production of the second messenger cAMP, which leads to the production of protein kinase A (PKA), which leads to further transcription in the nucleus. D2 to D4 receptors are coupled to G inhibitory sites to inhibit adenylyl cyclase and activate potassium Ion channel. These receptors utilize phosphorylation cascades or direct membrane interactions to affect the functions of voltage-gated and neurotransmitter-gated channels, cytoplasmic enzymes, and transcription factors. Dopamine receptor plays an important role in daily life.

MCE designs a unique collection of 195 small molecules related to dopamine receptor. It is a good tool for screening drugs from nervous system disease.

HY-L047

Endocrinology Compound Library	883 compounds
The endocrine system is a chemical messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs. Hormones are chemicals that serve to communicate between organs and tissues for physiological regulation and behavioral activities. Hormones affect distant cells by binding to specific receptor proteins in the target cell, resulting in a change in cell function. The endocrine system is concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioral activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones. Irregulated hormone release, inappropriate response to signaling or lack of a gland can lead to endocrine disease. MCE offers a unique collection of 883 endocrinology related compounds targeting varieties of hormone receptors such as thyroid hormone receptor, TSH receptor, GNRH receptor, adrenergic receptor, etc. MCE Endocrinology Compound Library is a useful tool for the discovery of endocrinology drugs.

Endocrinology Compound Library

883 compounds

The endocrine system is a chemical messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs. Hormones are chemicals that serve to communicate between organs and tissues for physiological regulation and behavioral activities. Hormones affect distant cells by binding to specific receptor proteins in the target cell, resulting in a change in cell function.

The endocrine system is concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioral activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones. Irregulated hormone release, inappropriate response to signaling or lack of a gland can lead to endocrine disease.

MCE offers a unique collection of 883 endocrinology related compounds targeting varieties of hormone receptors such as thyroid hormone receptor, TSH receptor, GNRH receptor, adrenergic receptor, etc. MCE Endocrinology Compound Library is a useful tool for the discovery of endocrinology drugs.

Cat. No.	Product Name	Target	Research Area

HY-P4073

ANG1005 GRN1005; Paclitaxel trevatide	Antibody-Drug Conjugates (ADCs)	Cancer
ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system .

Nobiletin 15+ Cited Publications	Structural Classification Flavonoids Neurological Disease Classification of Application Fields Flavones Source classification Rutaceae Plants Inflammation/Immunology Disease Research Fields Citrus reticulata Blanco	ROR Reactive Oxygen Species Apoptosis Autophagy
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a *retinoid acid receptor-related* orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis** .

Species:	Human (17) Mouse (4) Rat (2) Cynomolgus (1)
Tag:	His (21) Avi (3) Fc (3)
Source:	HEK293 (24)

Cat. No.	Compare	Product Name	Species	Source

HY-P76477

LRP-11 Protein, Human (HEK293, His)

Low-density lipoprotein receptor-related protein 11; LRP-11
Human HEK293

HY-P71263

	ROR2 Protein, Human (HEK293, His) Tyrosine-protein kinase transmembrane receptor ROR2; Neurotrophic tyrosine kinase, receptor-related 2; ROR2; NTRKR2	Human	HEK293
	The ROR2 protein is a tyrosine protein kinase receptor that plays a critical role in early chondrocyte formation and is essential for cartilage and growth plate development. Phosphorylated YWHAB induces osteogenesis and bone formation. ROR2 Protein, Human (HEK293, His) is the recombinant human-derived ROR2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ROR2 Protein, Human (HEK293, His) is 370 a.a., with molecular weight of 50-60 kDa.

HY-P70188

	Nectin-4 Protein, Cynomolgus (HEK293, His) rCynPoliovirus receptor-related protein 4-like/Nectin-4, His; PVRL4; Nectin-4; Ig superfamily receptor LNIR; Poliovirus receptor-related protein 4; PRR4; LNIR	Cynomolgus	HEK293
	Nectin-4 protein is an important member of the Nectin family and plays a vital role in cell adhesion and signaling, thereby affecting physiological functions. Its role in mediating cell-cell interactions emphasizes its importance in tissue organization. Nectin-4 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Nectin-4 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Nectin-4 Protein, Cynomolgus (HEK293, His) is 318 a.a., with molecular weight of 38-50 kDa.

HY-P72410

	ROR1 Protein, Human (Biotinylated, HEK293, His-Avi) Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophictyrosine kinase, receptor-related 1; NTRKR1	Human	HEK293
	ROR1 protein's minimal kinase activity in vitro suggests an improbable role as a tyrosine kinase in vivo. It serves as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Notably, ROR1 plays a vital role in the inner ear, facilitating innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived ROR1 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of ROR1 Protein, Human (Biotinylated, HEK293, His-Avi) is 374 a.a., with molecular weight of 55-80 kDa.

HY-P70732

	ROR1 Protein, Human (HEK293, His) Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophic tyrosine kinase, receptor-related 1; ROR1; NTRKR1	Human	HEK293
	ROR1 protein's minimal kinase activity in vitro suggests an improbable role as a tyrosine kinase in vivo. It serves as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Notably, ROR1 plays a vital role in the inner ear, facilitating innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Human (HEK293, His) is the recombinant human-derived ROR1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ROR1 Protein, Human (HEK293, His) is 374 a.a., with molecular weight of 60-80 kDa.

HY-P71263A

	ROR2 Protein, Human (HEK293, C-His) Tyrosine-protein kinase transmembrane receptor ROR2; Neurotrophic tyrosine kinase, receptor-related 2; ROR2; NTRKR2	Human	HEK293
	The ROR2 protein is a tyrosine protein kinase receptor that plays a critical role in early chondrocyte formation and is essential for cartilage and growth plate development. Phosphorylated YWHAB induces osteogenesis and bone formation. ROR2 Protein, Human (HEK293, C-His) is the recombinant human-derived ROR2 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of ROR2 Protein, Human (HEK293, C-His) is 370 a.a., with molecular weight of ~55 kDa.

HY-P76475

	LRP-10 Protein, Human (HEK293, Fc) Low-density lipoprotein receptor-related protein 10; LRP-10; MSTP087; SP220	Human	HEK293
	The LRP-10 protein is a possible receptor that may mediate internalization and/or signaling of lipophilic molecules. It is speculated that LRP-10 can promote the uptake of lipoprotein APOE in the liver and may play a role in lipid metabolism and processes related to lipoprotein transport. LRP-10 Protein, Human (HEK293, Fc) is the recombinant human-derived LRP-10 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of LRP-10 Protein, Human (HEK293, Fc) is 440 a.a., with molecular weight of 80-90 KDa.

HY-P76476

	LRP-10 Protein, Human (HEK293, His) Low-density lipoprotein receptor-related protein 10; LRP-10; MSTP087; SP220	Human	HEK293
	The LRP-10 protein is a possible receptor that may mediate internalization and/or signaling of lipophilic molecules. It is speculated that LRP-10 can promote the uptake of lipoprotein APOE in the liver and may play a role in lipid metabolism and processes related to lipoprotein transport. LRP-10 Protein, Human (HEK293, His) is the recombinant human-derived LRP-10 protein, expressed by HEK293 , with C-His labeled tag. The total length of LRP-10 Protein, Human (HEK293, His) is 424 a.a., with molecular weight of ~55 KDa.

HY-P70880

	Nectin-4 Protein, Mouse (HEK293, His) PVRL4; Nectin-4; Ig superfamily receptor LNIR; Poliovirus receptor-related protein 4; PRR4; LNIR	Mouse	HEK293
	Nectin-4 Protein participates in cell adhesion, engaging in trans-homophilic interactions with other Nectin-4 molecules and trans-heterophilic interactions, notably with NECTIN1. It can self-associate, with its Ig-like V-type domain interacting with NECTIN1's Ig-like V-type domain and its C-terminus interacting with AFDN. Nectin-4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Nectin-4 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Nectin-4 Protein, Mouse (HEK293, His) is 319 a.a., with molecular weight of 40-50 kDa.

HY-P70616

	Nectin-4 Protein, Human (HEK293, His) PVRL4; Nectin-4; Ig superfamily receptor LNIR; Poliovirus receptor-related protein 4; PRR4; LNIR; Nectin4	Human	HEK293
	The Nectin-4 Protein IgV domain is pivotal in cell adhesion, participating in trans-homophilic and -heterophilic interactions, notably with NECTIN1. While it doesn't serve as an alpha-herpesvirus entry receptor, it functions as a receptor for measles virus, enabling virus entry into host cells. This dual role underscores the importance of Nectin-4 in cell adhesion and its specific role as a measles virus infection receptor. Nectin-4 Protein, Human (HEK293, His) is the recombinant human-derived Nectin-4 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Nectin-4 Protein, Human (HEK293, His) is 320 a.a., with molecular weight of 40-47 kDa.

HY-P72401

	Nectin-4 Protein, Human (Biotinylated, HEK293, His-Avi) PVRL4; Nectin-4; Ig superfamily receptor LNIR; Poliovirus receptor-related protein 4; PRR4; LNIR	Human	HEK293
	The Nectin-4 Protein IgV domain is pivotal in cell adhesion, participating in trans-homophilic and -heterophilic interactions, notably with NECTIN1. While it doesn't serve as an alpha-herpesvirus entry receptor, it functions as a receptor for measles virus, enabling virus entry into host cells. This dual role underscores the importance of Nectin-4 in cell adhesion and its specific role as a measles virus infection receptor. Nectin-4 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Nectin-4 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of Nectin-4 Protein, Human (Biotinylated, HEK293, His-Avi) is 320 a.a., with molecular weight of 40-50 kDa.

HY-P70946

	LRP-12 Protein, Human (HEK293, His) Low-Density Lipoprotein receptor-related Protein 12; LRP-12; Suppressor of Tumorigenicity 7 Protein; LRP12; ST7	Human	HEK293
	LRP-12, a probable receptor, potentially facilitates the internalization of lipophilic molecules and signal transduction. It may function as a tumor suppressor and interacts with proteins RACK1, ZFYVE9, and NMRK2. LRP-12 Protein, Human (HEK293, His) is the recombinant human-derived LRP-12 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of LRP-12 Protein, Human (HEK293, His) is 456 a.a., with molecular weight of ~64-85 kDa.

HY-P73306

	Nectin-3/CD113 Protein, Human (400a.a, HEK293, His) Poliovirus receptor-related Protein 3; CDw113; Nectin-3; CD113; PVRL3; PRR3	Human	HEK293
	Nectin-3/CD113 is a multifunctional cell adhesion protein that mediates cell-cell interactions through heterophilic trans binding to nectin-like proteins or nectins. It interacts with NECTIN2 at the Sertoli cell-spermatocyte junction and triggers CDC42 and RAC small G protein activation through common signaling molecules such as SRC and RAP1. Nectin-3/CD113 Protein, Human (400a.a, HEK293, His) is the recombinant human-derived Nectin-3/CD113 protein, expressed by HEK293 , with C-His labeled tag. The total length of Nectin-3/CD113 Protein, Human (400a.a, HEK293, His) is 400 a.a., with molecular weight of 65-75 kDa.

HY-P72400

	Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, His-Avi) Poliovirus receptor-related Protein 2; Herpesvirus Entry Mediator B; HveB; CD112; PVRL2; HVEB; PRR2	Human	HEK293
	Nectin-2/CD112 protein has dual roles in T-cell signaling: as a costimulator with CD226, promoting proliferation and cytokine production, and as a coinhibitor with PVRIG, inhibiting proliferation. It also acts as a cell adhesion protein and a receptor for certain viruses. Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Nectin-2/CD112 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, His-Avi) is 329 a.a., with molecular weight of 45-60 kDa.

HY-P7782

	Nectin-3/CD113 Protein, Human (309a.a, HEK293, His) rHuCD113, His; Poliovirus receptor-related Protein 3; CDw113; Nectin-3; CD113; PVRL3; PRR3	Human	HEK293
	CD113 Protein, Human (HEK293, His) is a recombinant human CD113 expressed in HEK 293 cells with a His tag at the N-terminus. CD113 Protein is a member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities.

HY-P7780

	Nectin-2/CD112 Protein, Human (HEK293, His) rHuCD112, His; Poliovirus receptor-related Protein 2; Herpes Virus Entry Mediator B; Herpesvirus Entry Mediator B; CD112; PVRL2; HVEB; PRR2	Human	HEK293
	CD112 Protein, Human (HEK293, His) is a recombinant human CD112 expressed in HEK 293 cells with a His tag at the N-terminus. Recombinant Human CD112 can be used as cell surface ligands for the human DNAM-1 (CD226) activating molecule.

HY-P7781

	Nectin-2/CD112 Protein, Mouse (HEK293, His) rMuCD112, His; Poliovirus receptor-related Protein 2; Herpes Virus Entry Mediator B; Herpesvirus Entry Mediator B; CD112; PVRL2; HVEB; PRR2	Mouse	HEK293
	Nectin-2/CD112 Protein, Mouse (HEK293, His) is a recombinant mouse CD112 expressed in HEK 293 cells with a His tag at the N-terminus. Nectin-2/CD112 Protein can be used as cell surface ligands for the DNAM-1 (CD226) activating molecule.

HY-P70494

	Nectin-1 Protein, Human (HEK293, His) Poliovirus receptor-related Protein 1; Herpes Virus Entry Mediator C; Herpesvirus Entry Mediator C; HveC; Herpesvirus Ig-Like receptor; HIgR; Nectin-1; CD111; PVRL1; HVEC; PRR1	Human	HEK293
	Nectin-1 Protein mediates cell-cell contacts through homophilic or heterophilic trans-dimer formation, engaging in heterophilic interactions with Nectin-3 and Nectin-4. It also promotes neurite outgrowth. In microbial infection, Nectin-1 serves as a receptor for herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV). Nectin-1 Protein, Human (HEK293, His) is the recombinant human-derived Nectin-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Nectin-1 Protein, Human (HEK293, His) is 304 a.a., with molecular weight of 40-60 kDa.

HY-P77468

	Nectin-1 Protein, Mouse (HEK293, Fc) Poliovirus receptor-related Protein 1; Herpes Virus Entry Mediator C; Herpesvirus Entry Mediator C; HveC; Herpesvirus Ig-Like receptor; HIgR; Nectin-1; CD111; PVRL1; HVEC; PRR1	Mouse	HEK293
	Nectin-1 is critical in cell adhesion and synaptogenesis, promotes neurite outgrowth, and serves as a receptor for alphaherpesviruses, including HSV-1, HSV-2, and pseudorabies virus. It promotes viral entry and is involved in homodimerization, trans-heterodimerization with NECTIN3, and interactions with FGFR, AFDN, and HSV glycoprotein D. Nectin-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Nectin-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Nectin-1 Protein, Mouse (HEK293, Fc) is 354 a.a., with molecular weight of ~62.9 KDa.

HY-P77469

	Nectin-1 Protein, Mouse (HEK293, His) Poliovirus receptor-related Protein 1; Herpes Virus Entry Mediator C; Herpesvirus Entry Mediator C; HveC; Herpesvirus Ig-Like receptor; HIgR; Nectin-1; CD111; PVRL1; HVEC; PRR1	Mouse	HEK293
	Nectin-1 is critical in cell adhesion and synaptogenesis, promotes neurite outgrowth, and serves as a receptor for alphaherpesviruses, including HSV-1, HSV-2, and pseudorabies virus. It promotes viral entry and is involved in homodimerization, trans-heterodimerization with NECTIN3, and interactions with FGFR, AFDN, and HSV glycoprotein D. Nectin-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Nectin-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Nectin-1 Protein, Mouse (HEK293, His) is 324 a.a., with molecular weight of ~37.6 KDa.

HY-P77470

	Nectin-1 Protein, Rat (HEK293, Fc) Poliovirus receptor-related Protein 1; Herpes Virus Entry Mediator C; Herpesvirus Entry Mediator C; HveC; Herpesvirus Ig-Like receptor; HIgR; Nectin-1; CD111; PVRL1; HVEC; PRR1	Rat	HEK293
	Nectin-1 Protein, with carbohydrate and virion binding activities, plays pivotal roles in axon guidance, synapse assembly, and viral entry. Located in dendrites, growth cone membranes, and synapses, Nectin-1 is implicated in human conditions like cleft lip and ectodermal dysplasia. Its biased expression, especially in Kidney (RPKM 45.4) and Brain (RPKM 31.3), underscores its significance in diverse physiological contexts. Nectin-1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived Nectin-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Nectin-1 Protein, Rat (HEK293, Fc) is 354 a.a., with molecular weight of 88-98 kDa.

HY-P77471

	Nectin-1 Protein, Rat (HEK293, His) Poliovirus receptor-related Protein 1; Herpes Virus Entry Mediator C; Herpesvirus Entry Mediator C; HveC; Herpesvirus Ig-Like receptor; HIgR; Nectin-1; CD111; PVRL1; HVEC; PRR1	Rat	HEK293
	Nectin-1 Protein, with carbohydrate and virion binding activities, plays pivotal roles in axon guidance, synapse assembly, and viral entry. Located in dendrites, growth cone membranes, and synapses, Nectin-1 is implicated in human conditions like cleft lip and ectodermal dysplasia. Its biased expression, especially in Kidney (RPKM 45.4) and Brain (RPKM 31.3), underscores its significance in diverse physiological contexts. Nectin-1 Protein, Rat (HEK293, His) is the recombinant rat-derived Nectin-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Nectin-1 Protein, Rat (HEK293, His) is 324 a.a., with molecular weight of 55-60 kDa.

HY-P70923

	IL1RAPL1 Protein, Human (HEK293, His) Interleukin-1 receptor Accessory Protein-Like 1; IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; Oligophrenin-4; Three Immunoglobulin Domain-Containing IL-1 receptor-related 2; TIGIRR-2; X-Linked Interleukin-1 receptor Accessory Protein-Like 1; IL1RAPL1; OPHN4	Human	HEK293
	IL1RAPL1 protein is a multifaceted regulator that may inhibit N-type calcium channels, affecting secretion and presynaptic differentiation. It may activate MAP kinase JNK, suggesting involvement in intracellular signaling. IL1RAPL1 Protein, Human (HEK293, His) is the recombinant human-derived IL1RAPL1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IL1RAPL1 Protein, Human (HEK293, His) is 339 a.a., with molecular weight of 50-70 kDa.

HY-P71159

	RTN4RL1/NgR3 Protein, Human (395a.a, HEK293, His) Reticulon-4 receptor-Like 1; Nogo receptor-Like 2; Nogo-66 receptor Homolog 2; Nogo-66 receptor-related Protein 3; NgR3; RTN4RL1; NGRH2; NGRL2	Human	HEK293
	The RTN4RL1/NgR3 protein is a cell surface receptor that functionally affects postnatal brain development and axonal regeneration in the adult central nervous system. It aids in axonal migration across the midline of the brain and formation of the corpus callosum. RTN4RL1/NgR3 Protein, Human (395a.a, HEK293, His) is the recombinant human-derived RTN4RL1/NgR3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of RTN4RL1/NgR3 Protein, Human (395a.a, HEK293, His) is 395 a.a., with molecular weight of ~63.0 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P83622

DDR2 Antibody (YA3367) DDR2; NTRKR3; TKT; TYRO10; Discoidin domain-containing receptor 2; Discoidin domain receptor 2; CD167 antigen-like family member B; Discoidin domain-containing receptor tyrosine kinase 2; Neurotrophic tyrosine kinase; receptor-related 3; Re	WB	Human, Mouse, Rat

HY-P81390

ROR2 Antibody (YA1135)

NTRKR; ROR2; Tyrosine-protein kinase transmembrane receptor ROR2; Neurotrophic tyrosine kinase, receptor-related 2
IHC-P Human
HY-P82383

ApoER2 Antibody (YA2128)

LRP8; APOER2; Low-density lipoprotein receptor-related protein 8; LRP-8; Apolipoprotein E receptor 2
WB, IP Human, Rat, Hamster
HY-P83131

LRP2 Antibody (YA2876)

Low-density lipoprotein receptor-related protein 2; LRP-2; Glycoprotein 330; gp330; Megalin; LRP2; DBS
WB Human, Mouse, Rat

HY-P81451

Nectin 2 Antibody (YA1196) NECTIN2; HVEB, PRR2, PVRL2; CD112; Nectin-2; Herpes virus entry mediator B (Herpesvirus entry mediator B; HveB); Nectin cell adhesion molecule 2; Poliovirus receptor-related protein 2	IHC-P	Human

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