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Results for "

resistant+strain

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA synthetase (1) ADC Payload (1) Akt (1) Antibiotic (31) Antifolate (1) Apoptosis (2) Bacterial (79) Beta-lactamase (3) CCR (1) CDK (1) Cuproptosis (1) Cytochrome P450 (3) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (7) Drug Metabolite (1) EGFR (1) Endogenous Metabolite (3) Environmental Pollutants (1) Farnesyl Transferase (1) Fructose-1,6-bisphosphate aldolase (1) Fungal (15) GABA Receptor (1) HCV (2) HDAC (1) HIV (12) HIV Protease (2) HSV (3) Influenza Virus (2) Insecticide (1) Isotope-Labeled Compounds (3) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) P-glycoprotein (2) p38 MAPK (1) Parasite (23) Penicillin-binding protein (PBP) (1) PROTACs (1) Reactive Oxygen Species (ROS) (1) Reference Standards (10) Reverse Transcriptase (3) SARS-CoV (2) Succinate Dehydrogenase (1) Thymidylate Synthase (1) Topoisomerase (1) TrxR (1) VD/VDR (2) Virus Protease (1)
By Research Areas:	Cancer (20) Cardiovascular Disease (1) Infection (133) Inflammation/Immunology (9) Metabolic Disease (2) Neurological Disease (1)

By Targets:

Acetyl-CoA synthetase (1)

ADC Payload (1)

Akt (1)

Antibiotic (31)

Antifolate (1)

Apoptosis (2)

Bacterial (79)

Beta-lactamase (3)

CCR (1)

CDK (1)

Cuproptosis (1)

Cytochrome P450 (3)

Dihydrofolate reductase (DHFR) (1)

DNA/RNA Synthesis (7)

Drug Metabolite (1)

EGFR (1)

Endogenous Metabolite (3)

Environmental Pollutants (1)

Farnesyl Transferase (1)

Fructose-1,6-bisphosphate aldolase (1)

Fungal (15)

GABA Receptor (1)

HCV (2)

HDAC (1)

HIV (12)

HIV Protease (2)

HSV (3)

Influenza Virus (2)

Insecticide (1)

Isotope-Labeled Compounds (3)

Microtubule/Tubulin (1)

Mitochondrial Metabolism (1)

P-glycoprotein (2)

p38 MAPK (1)

Parasite (23)

Penicillin-binding protein (PBP) (1)

PROTACs (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (10)

Reverse Transcriptase (3)

SARS-CoV (2)

Succinate Dehydrogenase (1)

Thymidylate Synthase (1)

Topoisomerase (1)

TrxR (1)

VD/VDR (2)

Virus Protease (1)

By Research Areas:

Cancer (20)

Cardiovascular Disease (1)

Infection (133)

Inflammation/Immunology (9)

Metabolic Disease (2)

Neurological Disease (1)

145

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0509A

Amikacin Maximum Cited Publications 26 Publications Verification BAY 41-6551	Bacterial Antibiotic	Infection Cancer
Amikacin (BAY 41-6551) is a semisynthetic kanamycin analog that is active against most Gram-negative bacteria, including gentamicin- and tobramycin-resistant strains. Significant inhibitory effect. Amikacin is ototoxic and nephrotoxic. Amikacin can be used in bacteriostatic, anti-cancer and analgesic studies .

HY-N0315

Allicin Maximum Cited Publications 17 Publications Verification Diallyl thiosulfinate	Bacterial Antibiotic	Infection
Allicin (diallyl thiosulfinate) is isolated from garlic including Diallyl monosulfide, Diallyl disulfide, Diallyl trisulfide, Diallyl tetrasulfide, and Methyl allyl disulphide etc. They accounts for 98% of the extract. Allicin (diallyl thiosulfinate) has highly potent antimicrobial activity, and inhibits growth of a variety of microorganisms, among them antibiotic-resistant strains .

HY-N0402

Artemether 3 Publications Verification Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224	Parasite	Infection Inflammation/Immunology Cancer
Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria .

HY-B1268

Docusate Sodium 2 Publications Verification Dioctyl sulfosuccinate sodium salt	Environmental Pollutants HSV	Others
Docusate Sodium (Dioctyl sulfosuccinate sodium salt) is one of the main components in stool softeners. Docusate Sodium is a sulfated surfactant and may inactivate viral pathogens by disrupting viral envelopes and/or denaturing/disassociating proteins. Docusate Sodium is effective in vitro against wild type and drug-resistant strains of HSV type 1 and 2. Docusate Sodium is an obesogen. Docusate Sodium with developmental exposure leads to increased adult adiposity, inflammation, metabolic disorder and dyslipidemia in offspring fed a standard diet in mice .

HY-B0509B

Amikacin disulfate Maximum Cited Publications 26 Publications Verification BAY 41-6551 disulfate	Bacterial Antibiotic	Infection Cancer
Amikacin disulfate (BAY 41-6551 dissulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin disulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria .

HY-A0086

Netilmicin sulfate SCH-20569 sulfate	Bacterial Antibiotic	Infection
Netilmicin (Sch 20569) sulfate is a broad-spectrum semisynthetic aminoglycoside antibiotic. Netilmicin sulfate exhibits antibacterial activity against aminoglycoside-susceptible gram-negative strains and aminoglycoside-resistant strain, such as Escherichia coli, Pseudomonas aeruginosa, Proteus, Staphylococcus aureus, Streptococcus, Serratia, and Enterobacter, with MIC of 0.125-8 μg/mL .

HY-107813

Amikacin sulfate Maximum Cited Publications 26 Publications Verification BAY 41-6551 sulfate	Bacterial Antibiotic	Infection Cancer
Amikacin sulfate (BAY 41-6551 sulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin sulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin sulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin sulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria .

HY-14267

Lersivirine UK-453061	HIV Reverse Transcriptase	Infection
Lersivirine (UK-453061) is potent and selective non-nucleoside reverse transcription inhibitor (NNRTI; IC₅₀=119 nM) with excellent efficacy against NNRTI-resistant viruses. Lersivirine exhibits potent antiretroviral activity against wild-type HIV virus and clinically relevant NNRTI-resistant strains .

HY-14800

Radezolid 10+ Cited Publications RX-1741	Bacterial Antibiotic	Infection
Radezolid (RX-1741) is a oxazolidinone antibiotic. Radezolid is active against *Staphylococcus, Chlamydia, and Legionella* species, and remains active against Linezolid-resistant strains .

HY-B0343A

Sarafloxacin hydrochloride 2 Publications Verification A-56620 hydrochloride	Bacterial	Infection Inflammation/Immunology
Sarafloxacin hydrochloride (A-56620 hydrochloride) is a fluoroquinolone Antibacterial agent. Sarafloxacin inhibits the growth of Staphylococcus aureus, Enterobacteriaceae, and both aminoglycoside-sensitive and aminoglycoside-resistant strains of Pseudomonas aeruginosa .

HY-15975

GNF179	Parasite	Infection
GNF179 is an optimized 8,8-dimethyl imidazolopiperazine analog that exhibits antimalarial potency (IC₅₀ of 4.8 nM against the multidrug resistant strain W2). GNF179 is orally active .

HY-B0509

Amikacin hydrate Maximum Cited Publications 26 Publications Verification BAY 41-6551 hydrate	Bacterial Antibiotic	Infection Cancer
Amikacin hydrate (BAY 41-6551 hydrate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin hydrate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin hydrate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin hydrate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria .

HY-117766

PC945	Fungal Cytochrome P450	Infection
PC945, a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. PC945 is also a potent, tightly binding inhibitor of A. fumigatus sterol 14α-demethylase activity, CYP51A and CYP51B, with IC₅₀s of 0.23 μM and 0.22 μM, respectively .

HY-128914

Tubulysin	ADC Payload Microtubule/Tubulin Apoptosis	Cancer
Tubulysin is a microtubule destabilizer that binds to the β-tubulin peptide site adjacent to the vinca alkaloid binding site and inhibits tubulin polymerization. Tubulysin induces apoptosis and exhibits antiproliferative activity against a variety of human cancer cells, including multidrug-resistant strains. Tubulysin can be conjugated to antibodies via a disulfide-containing quaternary ammonium linker for ADC synthesis . Tubulysin is applicable to tumor-related research .

HY-125576

Griselimycin	Bacterial	Infection
Griselimycin is a cyclic lipopeptide produced by Streptomyces. Griselimycin specifically binds to the sliding clamp of bacterial DNA polymerase and does not interact with human PCNA. Griselimycin exhibits potent antibacterial activity against Mycobacterium tuberculosis (including drug-resistant strains) and a variety of Gram-negative bacteria .

HY-A0248B

Polymyxin B2	Antibiotic Bacterial	Infection
Polymyxin B2 is a polypeptide antibiotic that has antibacterial activity, particularly against gram-negative bacteria. Polymyxin B2 kills the bacteria by binding to lipopolysaccharide molecules on the bacterial cell membrane, disrupting the integrity of the cell membrane and causing the cell contents to leak. Polymyxin B2 can be used in antibiotic development and treatment of drug-resistant strains .

HY-N3386

Licoricone	Bacterial	Infection
Licoricone is an flavonoid extracted from licorice, exhibits anti-helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains .

HY-143899

FBA-IN-1	Fructose-1,6-bisphosphate aldolase Fungal	Infection
FBA-IN-1 (compound 2a11) is a first-in-class, covalent and allosteric inhibitor of fructose-1,6-bisphosphate aldolase from Candida albicans (CaFBA). FBA-IN-1 inhibits the growth of Azole-resistant strains 103 with the MIC₈₀ of 1 μg/mL .

HY-16745

Lascufloxacin KRP-AM1977	Beta-lactamase Bacterial Antibiotic	Infection
Lascufloxacin (KRP-AM1977X) is a potent and orally active fluoroquinolone antibacterial agent. Lascufloxacin potently inhibits infections caused by various pathogens, including quinolone-resistant strains. Lascufloxacin has the potential for various infectious diseases treatment, including lower respiratory tract infections .

HY-131981

TP0586532 2 Publications Verification	Bacterial	Infection Cardiovascular Disease
TP0586532 is a non-hydroxamate LpxC inhibitor (IC₅₀=0.101 μM). TP0586532 as a compound with a low cardiovascular risk that is effective against K. pneumoniae, including resistant strains . TP0586532 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-100358

AQ-13 dihydrochloride	Parasite	Infection
AQ-13 dihydrochloride is an aminoquinoline antimalarial agent that is effective against drug-resistant strains of Plasmodium falciparum.

HY-N0402S

Artemether-d3 Dihydroqinghaosu methyl ether-d₃; Dihydroartemisinin methyl ether-d₃; SM224-d₃	Isotope-Labeled Compounds Parasite	Infection Cancer
Artemether-d₃ is the deuterium labeled Artemether. Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.

HY-135578

Artelinic acid	Parasite	Infection
Artelinic acid, a derivative of Artemisinin, is an antimalarial agent for the treatment of multidrug resistant strains of Plasmodium falciparum. Artelinic acid can be administered by various routes of administration, including intravenous, intramuscular and oral routes .

HY-146145

Metyltetraprole	Fungal Mitochondrial Metabolism	Infection
Metyltetraprole is a promising fungicide with EC₅₀ values of both 0.002 ppm against sensitive wild-type and G143A mutant of Zymoseptoria tritici. Metyltetraprole is effective against QoI (quinone outside inhibitor) resistant strains. Metyltetraprole inhibits the respiratory chain via complex III .

HY-B0509AR

Amikacin (Standard) BAY 41-6551 (Standard)	Reference Standards Bacterial Antibiotic	Infection Cancer
Amikacin (Standard) is the analytical standard of Amikacin. This product is intended for research and analytical applications. Amikacin (BAY 41-6551), a semisynthetic analog of kanamycin, is very active against most gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin (BAY 41-6551) is ototoxic and nephrotoxic .

HY-127054

Netilmicin Sch 20569	Antibiotic Bacterial	Infection
Netilmicin (Sch 20569) is a broad-spectrum semisynthetic aminoglycoside antibiotic. Netilmicin exhibits antibacterial activity against aminoglycoside-susceptible gram-negative strains and aminoglycoside-resistant strain, such as Escherichia coli, Pseudomonas aeruginosa, Proteus, Staphylococcus aureus, Streptococcus, Serratia, and Enterobacter, with MIC of 0.125-8 μg/mL .

HY-N7634

Tectol	Farnesyl Transferase Parasite	Infection Cancer
Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM . Tectol is a farnesyltransferase (FTase) inhibitor with IC₅₀s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC₅₀ of 3.44 μM .

HY-N10430

Patentiflorin A	HIV	Infection
Patentiflorin A is a potent, broadspectrum HIV-1 inhibitor. Patentiflorin A also inhibits HIV drug-resistant strains .

HY-B0343

Sarafloxacin A-56620	Bacterial	Infection Inflammation/Immunology
Sarafloxacin (A-56620) is a fluoroquinolone Antibacterial agent. Sarafloxacin inhibits the growth of Staphylococcus aureus, Enterobacteriaceae, and both aminoglycoside-sensitive and aminoglycoside-resistant strains of Pseudomonas aeruginosa .

HY-172734

FG-2101	Bacterial	Infection
FG-2101 is a selective and orally active non-hydroxamate LpxC inhibitor with an IC₅₀ of ~1 nM. FG-2101 exhibits exquisite selectivity over other bacterial and human metalloenzymes. FG-2101 can be used for the study of Gram-negative bacteria infections including drug-resistant strains .

HY-130613

MAC-545496	Bacterial	Infection
MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR). MAC-545496 displays strong binding affinity to the full-length GraR protein (K_d ≤ 0.1 nM). MAC-545496 is an antivirulence agent that reverses β-lactam resistance in Methicillin-resistant strains (MRSA) .

HY-116271

Sperabillin C	Antibiotic Bacterial	Infection
Sperabillin C is an antibacterial antibiotic with activity against both Gram-negative and Gram-positive bacteria, including resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus .

HY-113958

Difethialone LM-2219	VD/VDR	Others
Difethialone (LM-2219) is an anticoagulant rodenticide. Difethialone shows high rodenticide activity in warfarin-sensitive and resistant strains of rats and mice. Difethialone interferes with the circulation of vitamin K in the liver, preventing the synthesis of coagulation factors, resulting in the inability of the blood to coagulate properly, ultimately causing internal bleeding and death. Difethialone can be used in studies of ecological impacts .

HY-E70077

Penicillinase (from calf stomach)	Endogenous Metabolite	Infection Metabolic Disease
Penicillinase (from calf stomach) is an enzyme that degrades penicillin by hydrolyzing the cyclic amide bonds in the lactam ring of penicillin, which can inactivate penicillin. Penicillinase (from calf stomach) can be isolated from penicillin resistant strains. Penicillinase (from calf stomach) has potential application as a marker for steroid hormone enzyme linked immunosorbent assay .

HY-P991653

HGS004	CCR HIV	Infection
HGS004 is a humanized IgG4 monoclonal antibody inhibitor targeting CCR5. HGS004 has potent antivival activity against a diverse panel of CCR5-tropic HIV-1 and durg (such as Maraviroc (HY-13004))-resistant strains. HGS004 can be used for HIV-1 infections research .

HY-153696

MRL-436	DNA/RNA Synthesis Bacterial	Infection
MRL-436 is a RNA polymerase inhibitor with antibacterial activity. MRL-436 exerts its antibacterial activity dependent on residue 622 of the RNA polymerase β' subunit and the RNAP ω subunit. MRL-436 inhibits Rifampicin (HY-B0272)-resistant RNA polymerase derivatives and exhibits antibacterial activity against Rifampicin-resistant strains .

HY-16745A

Lascufloxacin hydrochloride KRP-AM1977 hydrochloride	Bacterial	Infection
Lascufloxacin (KRP-AM1977) hydrochloride is a potent antibacterial compound candidate with broad-spectrum activity against various clinical isolates. Lascufloxacin hydrochloride shows the most potent activity against Gram-positive bacteria compared to other tested quinolones. Lascufloxacin hydrochloride demonstrates incomplete cross-resistance against existing quinolone-resistant strains. Lascufloxacin hydrochloride has potent inhibitory activity against both wild-type and mutated target enzymes.

HY-121348

Ficellomycin U-47929	Antibiotic Bacterial DNA/RNA Synthesis	Infection
Ficellomycin is a nitrogen-containing bicyclic antibiotic with strong activity against Gram-positive bacteria, including multidrug-resistant strains of Staphylococcus aureus. Ficellomycin works by inducing the formation of defective 34S DNA fragments, which interfere with the semi-conservative DNA replication process. These fragments lack the ability to integrate into larger DNA segments and eventually form a complete bacterial chromosome. Ficellomycin can be used in research for various bacterial diseases .

HY-178436

Antituberculosis agent-16	Bacterial	Infection
Antituberculosis agent-16 is an orally active antituberculosis agent. Antituberculosis agent-16 exhibits stable antituberculosis activity with a MIC of 0.48 μg/mL against Mycobacterium tuberculosis H37Rv sensitive strain and 0.49 μg/mL against multidrug-resistant strain 14862. Antituberculosis agent-16 shows high Caco-2 permeability. Antituberculosis agent-16 can be used for the research of infection .

HY-126640

Phomoxanthone A	Parasite	Infection Cancer
Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC₅₀ is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC₅₀ is 0.99, 0.51 and 1.4 µg/mL, respectively .

HY-N14902

Mimosamycin	Antibiotic Bacterial	Infection
Mimosamycin is an antibiotic. Mimosamycin has activity against mycobacteria and streptomyces resistant strains .

HY-N15059

Cissetin	Bacterial	Infection
Cissetin shows activity against Gram-positive bacteria, including drug-resistant strains .

HY-122551

Chlorfenethol	Insecticide	Others
Chlorfenethol is a dehydrochlorinase inhibitor. Chlorfenethol can be used as a synergist for insecticide DDT to increase its effect on resistant strains .

HY-N15526

Austroside A	Bacterial	Infection
Austroside A is found in Evodia austrosinensis. Austroside A shows antibacterial activity against the Staphylococcus aureus antibiotic resistant strain .

HY-136384

Diethofencarb	Fungal	Infection
Diethofencarb is a fungicide with strong activity against Botrytis cinerea and Benzimidazole-resistant strains of Botryis spp. Diethofencarb has a role as an antifungal agrochemical .

HY-122073

Furalazine	Bacterial	Infection
Furalazine is an antimicrobial agent. Furalazine shows activity against drug-resistant strains of cholera bacteria. Furalazine has the potential for the research of cholera .

HY-N14706

Kibdelin A	Bacterial	Infection
Kibdelin A is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .

HY-N0402R

Artemether (Standard) Dihydroqinghaosu methyl ether (Standard); Dihydroartemisinin methyl ether (Standard); SM224 (Standard)	Reference Standards Parasite	Infection Inflammation/Immunology Cancer
Artemether (Standard) is the analytical standard of Artemether. This product is intended for research and analytical applications. Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria .

HY-N14707

Kibdelin B	Bacterial	Infection
Kibdelin B is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .

HY-N8455

Isocudraniaxanthone A Assiguxanthone A	Parasite	Infection
Isocudraniaxanthone A is a xanthone that can be isolated from Garcinia vieillardii. Isocudraniaxanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC₅₀ of 2.3 μg/mL .

Cat. No.	Product Name

HY-L940

Antiviral Lead-like compound library

5,813 compounds

Owing to the widespread transmission and frequent mutation of viral diseases, as well as the continuous emergence of new viruses and drug-resistant strains, antiviral drug development is facing increasingly stringent requirements. Antiviral compound libraries serve as important tools for drug screening, mechanism research and development, enabling the discovery and investigation of various antiviral drugs.

These compounds act through diverse antiviral mechanisms, targeting key steps in viral replication, assembly and invasion. They exert antiviral effects by inhibiting viral nucleic acid synthesis, blocking viral protein processing, and preventing viral binding to host cells. This library covers various types of antiviral compounds, including nucleosides, non-nucleosides, protease inhibitors and integrase inhibitors. It supports research on influenza virus, herpes virus, hepatitis virus, emerging respiratory viruses and other pathogens, and enables high-throughput screening of novel antiviral candidates to rapidly identify potential active compounds against diverse viruses. It also facilitates mechanistic studies to elucidate drug-target interactions and viral resistance mechanisms, and supports the screening of effective compounds against mutant strains for research on viral variation and drug resistance.

This antiviral library consists of 6,804 compounds with lead-like physicochemical properties. The core sources of the compounds include analogs of known antiviral molecues with a similarity score ≥ 0.6. MCE has collected more than 1450 antiviral molecules. As a small-molecule collection with both activity potential and structural modifiability, it provides strong support for antiviral drug research and development.

Cat. No.	Product Name	Target	Research Area

HY-125576

Griselimycin	Bacterial	Infection
Griselimycin is a cyclic lipopeptide produced by Streptomyces. Griselimycin specifically binds to the sliding clamp of bacterial DNA polymerase and does not interact with human PCNA. Griselimycin exhibits potent antibacterial activity against Mycobacterium tuberculosis (including drug-resistant strains) and a variety of Gram-negative bacteria .

HY-A0248B

Polymyxin B2	Antibiotic Bacterial	Infection
Polymyxin B2 is a polypeptide antibiotic that has antibacterial activity, particularly against gram-negative bacteria. Polymyxin B2 kills the bacteria by binding to lipopolysaccharide molecules on the bacterial cell membrane, disrupting the integrity of the cell membrane and causing the cell contents to leak. Polymyxin B2 can be used in antibiotic development and treatment of drug-resistant strains .

HY-P11027

Thiazoplanomicin	Bacterial Antibiotic	Infection
Thiazoplanomicin (Compound 1) is a thiazolyl peptide antibiotic. Thiazoplanomicin can be isolated from the leaf-litter actinomycete Actinoplanes sp. MM794L-181F6. Thiazoplanomicin has potent antimicrobial activities against gonococcal strains (especially drug-resistant strains) and Gram-positive bacterium with MICs of 31.2-125 and 0.5-15.6 ng/mL, respectively. Thiazoplanomicin has no antibacterial activity against E.coli. Thiazoplanomicin can be used for bacterial infections research .

HY-P11102

Temporin-SHa	Bacterial Fungal HIV Parasite	Infection Cancer
Temporin-Sha is an antibacterial peptide with extensive biological activity. Temporin-Sha exhibits broad-spectrum antibacterial activity (e.g., against L. ivanovii, MIC = 6.25 μM), and is effective against Gram-negative bacteria (such as Escherichia coli, MIC = 10 μM), including drug-resistant strains (such as Methicillin (HY-121544)-resistant Staphylococcus aureus). Temporin-Sha also has inhibitory effects on Candida albicans (MIC = 25 μM), Saccharomyces cerevisiae (MIC = 12 μM), the pre-flagellated and non-flagellated forms of Leishmania infantum (IC₅₀ = 5-20 μM), and Trypanosoma cruzi (IC₅₀ = 17 μM). Temporin-Sha exhibits antiviral activity against HSV-1 and has anti-cancer effects (cytotoxicity against breast cancer cells MCF-7 and lung cancer cells H460, etc.) .

HY-P10411

BING	Bacterial	Infection
BING is an antimicrobial peptide that can be isolated from Japanese medaka fish. BING shows a broad-spectrum toxicity against pathogenic bacteria including drug-resistant strains. BING induces a deregulation of periplasmic peptidyl-prolyl isomerases in gram-negative bacteria, and reduces the RNA level of cpxR, which plays a crucial role in the development of antimicrobial resistance .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991653

HGS004	CCR HIV	Infection
HGS004 is a humanized IgG4 monoclonal antibody inhibitor targeting CCR5. HGS004 has potent antivival activity against a diverse panel of CCR5-tropic HIV-1 and durg (such as Maraviroc (HY-13004))-resistant strains. HGS004 can be used for HIV-1 infections research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0315

Allicin Maximum Cited Publications 17 Publications Verification Diallyl thiosulfinate	Infection Natural Products Liliaceae Classification of Application Fields Plants Disease Research Fields A．Sativam L. var．Viviparum Regel Source Classification	Bacterial Antibiotic
Allicin (diallyl thiosulfinate) is isolated from garlic including Diallyl monosulfide, Diallyl disulfide, Diallyl trisulfide, Diallyl tetrasulfide, and Methyl allyl disulphide etc. They accounts for 98% of the extract. Allicin (diallyl thiosulfinate) has highly potent antimicrobial activity, and inhibits growth of a variety of microorganisms, among them antibiotic-resistant strains .

HY-N0402

Artemether 3 Publications Verification Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224	Classification of Application Fields Terpenoids Sesquiterpenes Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Disease Research Fields Source Classification Cancer	Parasite
Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria .

HY-N7922

Urolithin M5 1 Publications Verification Decarboxyellagic acid	Structural Classification Canarium album (Lour.) Rauesch. Phenols Polyphenols Plants Burseraceae Source Classification	Influenza Virus p38 MAPK EGFR Akt Reactive Oxygen Species (ROS) Apoptosis
Urolithin M5 (Decarboxyellagic acid) is an orally active influenza virus neuraminidase inhibitor and neuroprotective agent, with IC₅₀ values of 174.8 μM (HK68), 191.5 μM (pdm09), 243.2 μM (WSN) and 257.1 μM (PR8) against four influenza virus neuraminidases, respectively. Urolithin M5 inhibits viral neuraminidase activity, thereby blocking influenza virus replication (including oseltamivir (HY-13317)-resistant strains), protecting infected mammals from death and improving pulmonary edema. Urolithin M5 forms a hydrogen-bond stabilized complex with IGF1R, and binds to MAPK14, AKT1, NFKB1 and EGFR. Urolithin M5 reduces reactive oxygen species production, inhibits neuronal apoptosis, restores mitochondrial transmembrane potential, and promotes neurite outgrowth of damaged neuronal cells. Urolithin M5 can be used in research related to influenza virus infection and Alzheimer's disease .

HY-N1136

(+)-Totarol	Infection Animals Classification of Application Fields Terpenoids Diterpenoids Disease Research Fields Source Classification	Bacterial
(+)-Totarol is a diterpenoid membrane-disrupting agent and membrane structure regulator found in plants of the genus Podocarpus spp. (+)-Totarol inserts into phospholipid model membranes, disrupts phospholipid packing, and impairs the functional integrity of membranes. (+)-Totarol exhibits antibacterial activity against a variety of bacterial species and β-lactam-resistant strains, and its action is associated with changes in membrane physical properties. (+)-Totarol can be used in studies related to bacterial infections .

HY-N0248

Saikosaponin B2 2 Publications Verification	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Umbelliferae Plants Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	HCV P-glycoprotein
Saikosaponin B2 is an antiviral and anticancer agent that regulates multiple transporters (such as various solute carriers and ATP-binding cassette transporters including MRP1, MRP2, and OCT2). Saikosaponin B2 is isolated from the plant glycoside component of the roots of Bupleurum scorzonerifolium. Saikosaponin B2 enhances the liver targeting of anticancer drugs via vinegar-baked Radix Bupleuri. Saikosaponin B2 inhibits HCV entry, replication, and translation, is effective against Daclatasvir (HY-10466)-resistant strains, and exerts a synergistic effect when used in combination with Daclatasvir. Saikosaponin B2 is commonly used in studies related to hepatocellular carcinoma and HCV infection .

HY-103249

Reutericyclin Reutericycline	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial
Reutericyclin (Reutericycline) is an orally active antibacterial and anti-obesity agent that selectively inhibits Gram-positive bacteria. By selectively dissipating transmembrane potential, Reutericyclin exerts non-lytic bactericidal or bacteriostatic activity against pathogens such as Clostridium difficile and Staphylococcus aureus, and rapidly kills vegetative cells and spores of Clostridium difficile. Reutericyclin possesses favorable properties including resistance to enzymatic hydrolysis, iron-chelating function, and poor absorption by colonic epithelium. Reutericyclin not only eradicates staphylococcal biofilms and inhibits drug-resistant strains, but also counteracts Risperidone (HY-11018)-induced weight gain by inducing changes in gut microbiota composition and restoring energy utilization efficiency. Reutericyclin can be used in research related to Clostridium difficile infection, Risperidone-induced weight gain, and staphylococcal superficial skin infections .

HY-N3386

Licoricone	Infection Flavonoids Monophenols Classification of Application Fields Leguminosae Phenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Isoflavones Source Classification	Bacterial
Licoricone is an flavonoid extracted from licorice, exhibits anti-helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains .

HY-N7634

Tectol	Infection other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification	Farnesyl Transferase Parasite
Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM . Tectol is a farnesyltransferase (FTase) inhibitor with IC₅₀s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC₅₀ of 3.44 μM .

HY-N10430

Patentiflorin A	Infection Classification of Application Fields Acanthaceae Justicia gendarussa N. L. Burman Lignans Phenylpropanoids Plants Disease Research Fields Source Classification	HIV
Patentiflorin A is a potent, broadspectrum HIV-1 inhibitor. Patentiflorin A also inhibits HIV drug-resistant strains .

HY-116271

Sperabillin C	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Sperabillin C is an antibacterial antibiotic with activity against both Gram-negative and Gram-positive bacteria, including resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus .

HY-121348

Ficellomycin U-47929	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial DNA/RNA Synthesis
Ficellomycin is a nitrogen-containing bicyclic antibiotic with strong activity against Gram-positive bacteria, including multidrug-resistant strains of Staphylococcus aureus. Ficellomycin works by inducing the formation of defective 34S DNA fragments, which interfere with the semi-conservative DNA replication process. These fragments lack the ability to integrate into larger DNA segments and eventually form a complete bacterial chromosome. Ficellomycin can be used in research for various bacterial diseases .

HY-126640

Phomoxanthone A	Quinones Microorganisms Anthraquinones Source Classification	Parasite
Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC₅₀ is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC₅₀ is 0.99, 0.51 and 1.4 µg/mL, respectively .

HY-N16422

Mer-NF5003E	Microorganisms Terpenoids Sesquiterpenes Source Classification	HIV HIV Protease
Mer-NF5003E is a non-nucleoside reverse transcriptase inhibitor targeting HIV-1 reverse transcriptase (RT) (EC₅₀=50 μM). Mer-NF5003E exhibits inhibitory activity against wild-type HIV-1 and multiple NNRTI-resistant strains (e.g., K103N, Y181C). Mer-NF5003E is promising for research of HIV infections .

HY-158721

Penicinoline Marinamide	Structural Classification Alkaloids Microorganisms Indole Alkaloids Source Classification	Endogenous Metabolite Parasite
Penicinoline (Marinamide) (Compound 1), a pyrrolyl 4-quinolinone alkaloid, is a microbial secondary metabolite. Penicinoline can be isolated from endophytic fungus Penicillium sp. Penicinoline has antimalarial activity against Chloroquine (HY-17589A) sensitive strain (pf3d7) and against Chloroquine resistant strain (pfDd2) of plasmodium falciparum. Penicinoline also has strong insecticidal activity against Aphis gossypii and selective anticancer effect with significant cytotoxicity for 95-D and HepG2 cells .

HY-N14902

Mimosamycin	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Mimosamycin is an antibiotic. Mimosamycin has activity against mycobacteria and streptomyces resistant strains .

HY-N15059

Cissetin	Natural Products Microorganisms Source Classification	Bacterial
Cissetin shows activity against Gram-positive bacteria, including drug-resistant strains .

HY-N15526

Austroside A	Annona squamosa L. Plants Annonaceae Saccharides Monosaccharides Source Classification	Bacterial
Austroside A is found in Evodia austrosinensis. Austroside A shows antibacterial activity against the Staphylococcus aureus antibiotic resistant strain .

HY-N14706

Kibdelin A	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Kibdelin A is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .

HY-N0402R

Artemether (Standard) Dihydroqinghaosu methyl ether (Standard); Dihydroartemisinin methyl ether (Standard); SM224 (Standard)	Structural Classification Terpenoids Sesquiterpenes Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Source Classification	Reference Standards Parasite
Artemether (Standard) is the analytical standard of Artemether. This product is intended for research and analytical applications. Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria .

HY-N14707

Kibdelin B	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Kibdelin B is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .

HY-N8455

Isocudraniaxanthone A Assiguxanthone A	Flavonoids Xanthones Calophyllum caledonicum Vieill. ex Planch. & Triana Phenols Plants Calophyllaceae Other Flavonoids Source Classification	Parasite
Isocudraniaxanthone A is a xanthone that can be isolated from Garcinia vieillardii. Isocudraniaxanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC₅₀ of 2.3 μg/mL .

HY-N14710

Kibdelin D	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Kibdelin D is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .

HY-N8338

Pancixanthone A	Flavonoids Guttiferae Garcinia vieillardii Pierre Plants Other Flavonoids Source Classification	Parasite
Pancixanthone A is a xanthone that can be isolated from Garcinia vieillardii. Pancixanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC₅₀ of 1.6 μg/mL .

HY-165272

Antibiotic SF-2132	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial Antibiotic
Antibiotic SF-2132 is a peptide antibiotic identified in Nocardiopsis sp., which exhibits inhibitory activity against β-lactam antibiotic-resistant strains, such as Pseudomonas and Escherichia .

HY-N14709

Kibdelin C2	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Kibdelin C2 is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .

HY-N2894

Piperolactam A	Alkaloids Piper betle L. Piperaceae Plants Source Classification	Parasite
Piperolactam A is a natural product that can be isolated from root of Piper betle. Piperolactam A exhibits promising leishmanicidal action against wild type and drug resistant strains of Leishmania donovani .

HY-N14708

Kibdelin C1	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Kibdelin C1 is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .

HY-N14955

3-O-α-D-Forosaminyl-(+)-griseusin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
3-O-α-D-Forosaminyl-(+)-griseusin is a memberof naphthoquinone antibiotic. 3-O-α-D-Forosaminyl-(+)-griseusin is active against Gram-positive bacteria including methicillin-resistant strain of Staphylococcus aureus (MRSA) .

HY-N15374

Hypercalin B	Natural Products Hypericum acmosepalum N. Robson Hypericaceae Plants Source Classification	Bacterial
Hypercalin B is an antibacterial agent that can be isolated from the hexane and chloroform extracts of the plant Hypericum acmosepalum. Hypercalin B exhibits inhibitory activity against multidrug-resistant strains of Staphylococcus aureus, with a MIC range of 0.5-128 mg/L .

HY-N8489

1-Methoxyphaseollidin	Infection Structural Classification Classification of Application Fields Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification	Endogenous Metabolite Bacterial
1-Methoxyphaseollidin, a flavonoid compound, is a lysoPAF acetyltransferase inhibitor, with an IC₅₀ of 48 μM. 1-Methoxyphaseollidin exhibits anti-H.pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains .

HY-119387

Chevalone B	Other Terpenoids Microorganisms Terpenoids Source Classification	Bacterial
Chevalone B was isolated from the ethyl acetate extract of the marine sponge-associated fungus Aspergillus similanensis. The structure of Chevalone B was confirmed by 1D and 2D NMR spectroscopy. Chevalone B showed antimicrobial activity against Gram-positive and Gram-negative bacteria, Candida albicans, and multidrug-resistant strains from the environment. Studies on Chevalone B have shown its potential value in antimicrobial applications.

HY-N0248R

Saikosaponin B2 (Standard)	Triterpenes Structural Classification Terpenoids Umbelliferae Plants Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	Reference Standards P-glycoprotein HCV
Saikosaponin B2 (Standard) is the analytical standard of Saikosaponin B2. This product is intended for research and analytical applications. Saikosaponin B2 is an antiviral and anticancer agent that regulates multiple transporters (such as various solute carriers and ATP-binding cassette transporters including MRP1, MRP2, and OCT2). Saikosaponin B2 is isolated from the plant glycoside component of the roots of Bupleurum scorzonerifolium. Saikosaponin B2 enhances the liver targeting of anticancer drugs via vinegar-baked Radix Bupleuri. Saikosaponin B2 inhibits HCV entry, replication, and translation, is effective against Daclatasvir (HY-10466)-resistant strains, and exerts a synergistic effect when used in combination with Daclatasvir. Saikosaponin B2 is commonly used in studies related to hepatocellular carcinoma and HCV infection .

Cat. No.	Product Name	Chemical Structure

HY-N0402S

Artemether-d3
Artemether-d₃ is the deuterium labeled Artemether. Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.

HY-W768856

Artemether-13C,d3
Artemether- ¹³C,d₃ (Dihydroqinghaosu methyl ether- ¹³C,d₃) is the deuterium and ¹³C-labeled Artemether (HY-N0402). Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria .

HY-113958S

Difethialone-d4

Difethialone-d₄ (Baraki-d₄; LM 2219-d₄) is the deuterium labeled Difethialone (HY-113958). Difethialone (LM-2219) is an anticoagulant rodenticide. Difethialone shows high rodenticide activity in warfarin-sensitive and resistant strains of rats and mice. Difethialone interferes with the circulation of vitamin K in the liver, preventing the synthesis of coagulation factors, resulting in the inability of the blood to coagulate properly, ultimately causing internal bleeding and death. Difethialone can be used in studies of ecological impacts .

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