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Results for "

responsiveness

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Androgen Receptor (2) Apoptosis (1) Biochemical Assay Reagents (1) Calcium Channel (1) Dipeptidyl Peptidase (2) Drug Metabolite (1) Drug-Linker Conjugates for ADC (1) EGFR (1) Endogenous Metabolite (1) Epigenetic Reader Domain (1) Estrogen Receptor/ERR (1) Fluorescent Dye (5) G protein-coupled Bile Acid Receptor 1 (1) Glucocorticoid Receptor (1) HIF/HIF Prolyl-Hydroxylase (2) HIV (1) HSP (1) IGF-1R (1) IRE1 (1) Liposome (1) p38 MAPK (1) PROTACs (1) Protein Arginine Deiminase (1) Topoisomerase (1) Wnt (3) β-catenin (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (2) Endocrinology (1) Infection (2) Inflammation/Immunology (4) Metabolic Disease (5) Neurological Disease (2)

By Targets:

Androgen Receptor (2)

Apoptosis (1)

Biochemical Assay Reagents (1)

Calcium Channel (1)

Dipeptidyl Peptidase (2)

Drug Metabolite (1)

Drug-Linker Conjugates for ADC (1)

EGFR (1)

Endogenous Metabolite (1)

Epigenetic Reader Domain (1)

Estrogen Receptor/ERR (1)

Fluorescent Dye (5)

G protein-coupled Bile Acid Receptor 1 (1)

Glucocorticoid Receptor (1)

HIF/HIF Prolyl-Hydroxylase (2)

HIV (1)

HSP (1)

IGF-1R (1)

IRE1 (1)

Liposome (1)

p38 MAPK (1)

PROTACs (1)

Protein Arginine Deiminase (1)

Topoisomerase (1)

Wnt (3)

β-catenin (1)

By Research Areas:

Cancer (14)

Cardiovascular Disease (2)

Endocrinology (1)

Infection (2)

Inflammation/Immunology (4)

Metabolic Disease (5)

Neurological Disease (2)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16665

iCRT 14 Maximum Cited Publications 10 Publications Verification	Wnt	Cancer
iCRT 14 is a novel potent inhibitor of *β-catenin-responsive* transcription (CRT), with IC₅₀** of 40.3 nM against Wnt responsive STF16 luciferase.

HY-116553

FzM1	Wnt β-catenin	Cancer
FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC_50inh=−6.2). FzM1 binds to an allosteric binding site located in intracellular loop 3 (ICL3) of FZD4 and alters the conformation of the receptor, ultimately inhibiting the WNT/β-catenin cascade .

HY-103705

iCRT3

5+ Cited Publications

Wnt Apoptosis Cancer

iCRT3 is an inhibitor of both Wnt and β-catenin-responsive transcription.

iCRT3 5+ Cited Publications	Wnt Apoptosis	Cancer
iCRT3 is an inhibitor of both Wnt and *β-catenin-responsive* transcription**.

HY-161341

*β-Glucuronidase responsive* conjugate 1**	Others	Cancer
β-Glucuronidase responsive conjugate 1 (compound 3) is a well-balanced photosensitizer which has photodynamic activity. β-Glucuronidase responsive conjugate 1 inhibits T-24 cell viability and growth with an IC₅₀ of 0.2 μM. β-Glucuronidase responsive conjugate 1 can used to study bladder cancers .

HY-157157

PAD4-IN-3	Protein Arginine Deiminase	Cancer
PAD4-IN-3 (compound 4B) is a PAD4 inhibitor with antitumor activity in vitro and in vivo. PAD4-IN-3 was covalently linked to RGD sequence peptide-modified chitosan (K-CRGDV), resulting in an enhanced oxidative stress-responsive nanoagent. K-CRGDV-PAD4-IN-3 can actively target tumors, inhibit PAD4 activity, block the formation of neutrophil extracellular traps (NETs), and improve the tumor immune microenvironment in response to the tumor microenvironment .

HY-144768

(R)-Chol-TPP

Liposome Others

(R)-Chol-TPP a mitochondria targeting liposome ligand could be used in pH-redox responsive .
HY-139623

A4B17

Androgen Receptor Cancer

A4B17 is an androgen receptor N-terminal inhibitor for researching androgen-responsive prostate cancer.

(R)-Chol-TPP	Liposome	Others
(R)-Chol-TPP a mitochondria targeting liposome ligand could be used in pH-redox responsive .

A4B17	Androgen Receptor	Cancer
A4B17 is an androgen receptor N-terminal inhibitor for researching androgen-responsive prostate cancer.

HY-107961

Diflorasone diacetate	Others	Inflammation/Immunology
Diflorasone diacetate is an anti-inflammatory steroid compound used as locally or topically agent. Diflorasone diacetate is being used for skin disorders to control corticosteroid-responsive dermatoses .

HY-110135

NBI-31772	IGF-1R	Others
NBI-31772 is the potent and nonselective inhibitor of IGFBP with a K_i value of 47 nM. NBI-31772 has the potential for the research of IGF-responsive diseases .

HY-111896

7-Methoxyrosmanol 7-O-Methoxyrosmanol	Others	Others
7-Methoxyrosmanol (7-O-Methoxyrosmanol), a phenolic diterpene isolated from rosemary, suppresses the cAMP responsiveness of PEPCK and G6Pase promoters .

HY-B1616

Clobetasone butyrate 1 Publications Verification	Glucocorticoid Receptor	Inflammation/Immunology
Clobetasone butyrate is a synthetic glucocorticoid and has topical anti-inflammatory activity especially in skin. Clobetasone butyrate can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis and psoriasis .

HY-W127770

Pararosaniline hydrochloride	Fluorescent Dye	Others
Pararosaniline hydrochloride is a pH-responsive basic dye, as a biological stain to track certain proteins. Pararosaniline hydrochloride has been used in the analysis of SO₂ and formaldehyde and staining of bacteria or other organisms .

HY-156518

Glucose-malemide	Biochemical Assay Reagents	Metabolic Disease
Glucose-malemide is a glycoconjugate consisting of a glucose molecule and a maleimide group of a linker molecule. Glucose-malemide can be used in the preparation of glucose-responsive insulin delivery compositions, thereby conjugating glucose to insulin .

HY-152102

BTCy	Fluorescent Dye	Cancer
BTCy is a near-infrared (NIR) fluorescence probe with polarity-responsive and cell plasma membrane-targeting properties. BTCy can be used for in vivo imaging of tumor tissue (λ_ex = 561 nm, λ_em = 600-700 nm) .

HY-P1586

HIV-1 Rev (34-50) HIV-1 rev Protein (34-50)	HIV	Infection
HIV-1 Rev (34-50) is a 17-aa peptide derived from the Rev-responsive element (RRE)-binding domains of Rev in HIV-1, with anti-HIV-1 activity.

HY-109564

5α-Pregnane-3β,6α-diol-20-one	Drug Metabolite	Cancer
5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells.

HY-111444

Auxinole Maximum Cited Publications 10 Publications Verification	Others	Others
Auxinole is a potent auxin antagonist of TIR1/AFB receptors, binding TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex and so inhibits auxin-responsive gene expression.

HY-129736A

P32/98	Dipeptidyl Peptidase	Metabolic Disease
P32/98 a potent inhibitor of dipeptidyl peptidase IV with a K_i value of 130 nM. P32/98 improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model .

HY-19337

Ketodarolutamide 1 Publications Verification BAY 1896953; ORM-15341	Androgen Receptor	Endocrinology
Ketodarolutamide (ORM-15341) is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct.

HY-A0150

Alclometasone 7a-Chloro-16a-methyl prednisolone
Alclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory mediators from leukocytes. Alclometasone can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis, eczema, psoriasis and allergic dermatitis .

HY-129736

P32/98 hemifumarate	Dipeptidyl Peptidase	Metabolic Disease
P32/98 hemifumarateis a potent inhibitor of dipeptidyl peptidase IV with a K_i value of 130 nM. P32/98 hemifumarate improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model .

HY-148335

IRG1-IN-1	Others	Infection Inflammation/Immunology Cancer
IRG1-IN-1 is an itaconic acid derivative. IRG1-IN-1 can inhibit *immune-responsive* gene 1 (IRG1)** activity. IRG1-IN-1 can be used for the research of cancer, inflammation and autoimmune diseases .

HY-128943

MAC glucuronide phenol-linked SN-38	Drug-Linker Conjugates for ADC	Cancer
MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) agent linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC₅₀ values of 113 and 67 ng/mL, respectively.Albumin-coupled MAC glucosidol-linked SN-38 shows good stability in mouse plasma .

HY-144769

SDOX	Topoisomerase	Cancer
SDOX is the Doxorubicin (DOX) proagent. The loaded DOX proagents (SDOX) which can release the parent agents DOX triggered by excessive GSH in tumor cells, minimize the unexpected side effects on normal tissues without compromising the potency .

HY-19399B

Iroxanadine sulfate (-)-BRX 005 sulfate; (-)-BRX 235 sulfate	p38 MAPK HSP	Cardiovascular Disease
Iroxanadine ((-)-BRX 005) sulfate is a potent activator of p38 kinase, and an enhancer of stress-responsive heat shock protein (Hsp) expression. Iroxanadine sulfate also is a vasculoprotector against atherosclerosis. Iroxanadine sulfate may improve survival of vascular endothelial cells (ECs) following ischemia/reperfusion stress .

HY-144304

PROTAC EGFR degrader 2	PROTACs EGFR	Cancer
PROTAC EGFR degrader 2 is a potent PROTAC EGFR degrader. PROTAC EGFR degrader 2 exhibits excellent antiproliferative activity with IC₅₀ of 4.0 nM and good EGFR degradation activity with DC50 of 36.51 nM. PROTAC EGFR degrader 2 can be used for the synthesis of nitroreductase (NTR)-responsive PROTAC .

HY-N6901

Luteolin 7-sulfate	Epigenetic Reader Domain	Metabolic Disease
Luteolin 7-sulfate is isolated from Phyllospadix iwatensis Makino, a marine plant. Luteolin 7-sulfate attenuates TYR gene expression through the intervention of a cAMP-responsive element binding protein (CREB)- and microphthalmia-associated transcription factor (MITF)-mediated signaling pathway, leading to the decreased melanin synthesis .

HY-118543

TM6089	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
TM6089 is a unique Prolyl Hydroxylase (PHD) inhibitor which stimulates HIF activity without iron chelation and induces angiogenesis and exerts organ protection against ischemia. Local administration of TM6089 enhances angiogenesis, and oral administration stimulates HIF activity in transgenic rats expressing a hypoxia-responsive reporter vector .

HY-149318

VRT-534	Others	Others
VRT-534 targets connexin 26 (Cx26). Vrt-534 exhibits dose-responsive binding to recombinant WT Cx26 and mutant Cx26 K188N with EC₅₀ value of 19 μM and 5 μM, respectively. Vrt-534 can be used in research related to hearing impairment .

HY-W187305

MASM7	Others	Others
MASM7 is a mitofusin activator, and can achieve mitochondrial fusion via mitofusins. MASM7 can increase Mito AR with an EC₅₀ value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN. MASM7 also demonstrates direct binding to the HR2 domain of MFN2 with K_d value of 1.1 μM .

HY-D1547

1-(3',6'-Bis(ethylamino)-2',7'-dimethyl-3-oxospiro[isoindoline-1,9'-xanthen]-2-yl)-3-phenylurea	Fluorescent Dye	Others
1-(3',6'-Bis(ethylamino)-2',7'-dimethyl-3-oxospiro[isoindoline-1,9'-xanthen]-2-yl)-3-phenylurea (compound 1a) can be used as a fast-responsive fluorescent gold ion probe for detection of gold ions in water and synthetic products .

HY-W017050

2-Hydroxypropyl acrylate	Others	Others
2-Hydroxypropyl acrylate (HPA) is a severe irritant and corrosive to the skin. 2-Hydroxypropyl acrylate (HPA) is extensively applied in fibre, adhesives, rubber industry, paints and coatings industry .

HY-151536

meso-Benzothiazole-BODIPY 505/515	Fluorescent Dye	Neurological Disease
meso-Benzothiazole-BODIPY 505/515 is a boron dipyrromethenes (BODIPY) -based fluorescent proberesponsive and aggregation-induced emission (AIE) properties. meso-Benzothiazole-BODIPY 505/515 can monitor cellular viscosity changes and autophagy. meso-Benzothiazole-BODIPY 505/515 can be used for the research of Alzheimer’s diseases, lysosomal storage diseases and neural degeneration diseases .

HY-116953

Lipoxin B4 LXB4	Endogenous Metabolite	Inflammation/Immunology
Lipoxin B4 (LXB4) is a structurally distinct product of arachidonic acid metabolism. Lipoxin B4 reduces leukocyte infiltration and mucus secretion in the nasal mucosa and decreases mast cell and eosinophil degranulation in the upper airway. Lipoxin B4 decreases airway inflammation, mucus metaplasia and hyper- responsiveness in the lower airway. Lipoxin B4 shows mucosal protective actions and has the potential for the research of allergic inflammation in the upper and lower airways .

HY-139214

IXA4 2 Publications Verification	IRE1	Neurological Disease
IXA4 is a highly selective, non-toxic IRE1/XBP1s activator. IXA4 activates IRE1/XBP1s signaling without globally activating the unfolded protein response (UPR) or other stress-responsive signaling pathways (e.g., the heat shock response or oxidative stress response). IXA4 reduces secretion of APP through IRE1 activation .

HY-147507

SBP-1	Fluorescent Dye	Others
SBP-1 is a sulfite bioluminescent probe (SBP). SBP-1 exhibits the excellent responsivity, selectivity and sensitivity towards sulfite. The recognition of SBP-1 towards sulfite is based on the mechanism of a sulfite-mediated intramolecular cleavage reaction. SBP-1 can be used for detection of exogenous and endogenous sulfite in living animal. SBP-1 also possesses a capability for quantitatively detecting sulfite within a certain concentration range in solution .

HY-136748

HIF-2α-IN-4 1 Publications Verification	HIF/HIF Prolyl-Hydroxylase	Cancer
HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC₅₀ of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5'UTR iron-responsive element to oxygen sensing .

HY-131404

TPBM	Estrogen Receptor/ERR	Cancer
TPBM is a potent estrogen receptor α (ERα) inhibitor with an IC₅₀ value of 9 μM for 17β-estradiol (E2)-ERα. TPBM reduces E2·ERα recruitment to an endogenous estrogen-responsive gene. TPBM inhibits E2-dependent growth of ERα-positive cancer cells (IC₅₀=5 μM). TPBM is not toxic to cells and does not affect estrogen-independent cell growth .

HY-14229

TGR5 Receptor Agonist 1 Publications Verification CCDC	G protein-coupled Bile Acid Receptor 1 Calcium Channel	Metabolic Disease
TGR5 Receptor Agonist (CCDC), a potent Takeda G protein-coupled receptor 5 (TGR5; GPCR19) agonist, shows improved potency in the U2-OS cells and melanophore cells with pEC₅₀s of 6.8 and 7.5, respectively. TGR5 Receptor Agonist can induce peripheral and central hypersensitivity to bladder distension in mice, and increase intracellular Ca ²⁺ concentration. TGR5 Receptor Agonist can also reduces food intake and improves insulin responsiveness, in diet-induced obese mice. TGR5 Receptor Agonist can be used to research diabetes, bladder hypersensitivity and anti-obesity .

Pararosaniline hydrochloride	Dyes
Pararosaniline hydrochloride is a pH-responsive basic dye, as a biological stain to track certain proteins. Pararosaniline hydrochloride has been used in the analysis of SO₂ and formaldehyde and staining of bacteria or other organisms .

1-(3',6'-Bis(ethylamino)-2',7'-dimethyl-3-oxospiro[isoindoline-1,9'-xanthen]-2-yl)-3-phenylurea	Fluorescent Dyes/Probes
1-(3',6'-Bis(ethylamino)-2',7'-dimethyl-3-oxospiro[isoindoline-1,9'-xanthen]-2-yl)-3-phenylurea (compound 1a) can be used as a fast-responsive fluorescent gold ion probe for detection of gold ions in water and synthetic products .

(R)-Chol-TPP	Drug Delivery
(R)-Chol-TPP a mitochondria targeting liposome ligand could be used in pH-redox responsive .

GHGVYGHGVYGHGPYGHGPYGHGLYW DgHBP-2	Peptides	Others
GHGVYGHGVYGHGPYGHGPYGHGLYW (DgHBP-2) is 26-amino-acid-long consensus peptide derived from histidine-rich beak protein-2 (DgHBP-2). GHGVYGHGVYGHGPYGHGPYGHGLYW can be used fabricated glucose-responsive insulin delivery system .

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