s100a9

By Targets:	Aryl Hydrocarbon Receptor (1) Cytochrome P450 (1) HDAC (3) Interleukin Related (1) Isotope-Labeled Compounds (3) Reactive Oxygen Species (ROS) (1) Reference Standards (2) ROCK (1) SARS-CoV (4) Small Interfering RNA (siRNA) (3) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Inflammation/Immunology (5) Metabolic Disease (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100442

Paquinimod 30+ Cited Publications ABR-215757; ABR 25757	SARS-CoV	Metabolic Disease Inflammation/Immunology
Paquinimod (ABR 215757) is a specific and orally active inhibitor of *S100A8/S100A9*. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .

HY-10528

Tasquinimod 15+ Cited Publications ABR-215050	HDAC	Cancer
Tasquinimod is an oral antiangiogenic agent, which has the potential for castration-resistant prostate cancer treatment. Tasquinimod binds to the regulatory Zn ²⁺ binding domain of HDAC4 with K_d of 10-30 nM. Tasquinimod also is a *S100A9* inhibitor .

HY-RS12386

S100A9 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
S100A9 Human Pre-designed siRNA Set A contains three designed siRNAs for S100A9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

S100A9 Human Pre-designed siRNA Set A S100A9 Human Pre-designed siRNA Set A

HY-P991517

BI-836858	Transmembrane Glycoprotein Reactive Oxygen Species (ROS)	Cardiovascular Disease Cancer
BI-836858 is a fully human anti-CD33 monoclonal antibody. BI-836858 reduces CD33+ cells via antibody-dependent cellular cytotoxicity (ADCC), blocks downstream signaling of *S100A9/CD33*, decreases the secretion of immunosuppressive cytokines and reactive oxygen species-induced genomic instability, and restores bone marrow hematopoietic function. BI-836858 is applicable to the research of myelodysplastic syndrome (MDS) and AML .

HY-RS16579

S100a9 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
S100a9 Mouse Pre-designed siRNA Set A contains three designed siRNAs for S100a9 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

S100a9 Mouse Pre-designed siRNA Set A S100a9 Mouse Pre-designed siRNA Set A

HY-RS23013

S100a9 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
S100a9 Rat Pre-designed siRNA Set A contains three designed siRNAs for S100a9 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

S100a9 Rat Pre-designed siRNA Set A S100a9 Rat Pre-designed siRNA Set A

HY-100442S1

Paquinimod-d5-1 ABR-215757-d₅-1; ABR 25757-d₅-1	SARS-CoV Isotope-Labeled Compounds	Metabolic Disease Inflammation/Immunology
Paquinimod-d5-1 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of *S100A8/S100A9*. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .

HY-10528S

Tasquinimod-d3 ABR-215050-d₃	HDAC Isotope-Labeled Compounds	Cancer
Tasquinimod-d3 (ABR-215050-d3) is the deuterium labeled Tasquinimod (HY-10528). Tasquinimod is an oral antiangiogenic agent, which plays an important role in castration-resistant prostate cancer. Tasquinimod binds to the regulatory Zn ²⁺ binding domain of HDAC4 with K_d of 10-30 nM. Tasquinimod also is a *S100A9* inhibitor .

HY-178053

AHR agonist 10	Aryl Hydrocarbon Receptor Cytochrome P450 Interleukin Related	Inflammation/Immunology
AHR agonist 10 is a potent AHR agonist (EC₅₀ = 2.01 nM). AHR agonist 10 can elevate the transcript levels of key AHR downstream pathway target genes, including CYP1A1 and CYP1B1. AHR agonist 10 can downregulate the expression levels of CD36, IL-18 and shows low cytotoxicity (>40 μM) to normal cells. AHR agonist 10 can suppress the expression of CCL5, CCL20, IL-6, IL-8, S100A9, TLR4, TNF-α, and TNFR1, demonstrating that AHR agonist 10 effectively modulate inflammatory responses through AHR dependent signaling pathways. AHR agonist 10 can be used for psoriasis research .

HY-100442S

Paquinimod-d5 ABR-215757-d₅; ABR 25757-d₅	SARS-CoV Isotope-Labeled Compounds	Metabolic Disease
Paquinimod-d5 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of *S100A8/S100A9*. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .

HY-100442R

Paquinimod (Standard) ABR-215757 (Standard); ABR 25757 (Standard)	Reference Standards SARS-CoV	Metabolic Disease Inflammation/Immunology
Paquinimod (Standard) is the analytical standard of Paquinimod. This product is intended for research and analytical applications. Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .

HY-10528R

Tasquinimod (Standard) ABR-215050 (Standard)	Reference Standards HDAC	Cancer
Tasquinimod (Standard) is the analytical standard of Tasquinimod. This product is intended for research and analytical applications. Tasquinimod is an oral antiangiogenic agent, which has the potential for castration-resistant prostate cancer treatment. Tasquinimod binds to the regulatory Zn2+ binding domain of HDAC4 with Kd of 10-30 nM. Tasquinimod also is a S100A9 inhibitor .

HY-181576

ROCK2-IN-14	ROCK	Inflammation/Immunology
ROCK2-IN-14 is an orally active, selective ROCK2 inhibitor (IC₅₀=4.8 nM) with 212-fold selectivity over ROCK1 (IC₅₀=1.01 μM). By inhibiting the *ROCK2/S100A9* signaling pathway, ROCK2-IN-14 downregulates S100A9 expression, inhibits NM2 phosphorylation and restores cytoskeletal abnormalities. Furthermore, ROCK2-IN-14 reduces inflammatory cytokine levels, alleviates skin inflammation and exerts anti-inflammatory activity. ROCK2-IN-14 also significantly inhibits ear thickening in a mouse model of atopic dermatitis (AD), and decreases the levels of IgE, TNF-α, IL-6 and TSLP. ROCK2-IN-14 can be used for research on atopic dermatitis .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991517

BI-836858	Transmembrane Glycoprotein Reactive Oxygen Species (ROS)	Cardiovascular Disease Cancer
BI-836858 is a fully human anti-CD33 monoclonal antibody. BI-836858 reduces CD33+ cells via antibody-dependent cellular cytotoxicity (ADCC), blocks downstream signaling of *S100A9/CD33*, decreases the secretion of immunosuppressive cytokines and reactive oxygen species-induced genomic instability, and restores bone marrow hematopoietic function. BI-836858 is applicable to the research of myelodysplastic syndrome (MDS) and AML .

Species:	Human (4) Rat (1) Mouse (2) Cynomolgus (1) Canine (1)
Tag:	His (8) Tag Free (1)
Source:	Sf9 insect cells (1) E. coli (8)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P77830

	S100A9 Protein, Canine (His) S100-A9; Calgranulin-B; Calprotectin L1H subunit; MRP-14; p14; CAGB; MRP14	Canine	E. coli
	The S100A9 protein is a calcium and zinc binder that plays a critical regulatory role in inflammation and immune responses. Its diverse functions include induction of neutrophil chemotaxis, adhesion, enhanced bactericidal activity through SYK, PI3K/AKT and ERK1/2 activation, and promotion of phagocytosis. S100A9 Protein, Canine (His) is the recombinant canine-derived S100A9 protein, expressed by E. coli , with N-His labeled tag.

HY-P77829

	S100A9 Protein, Cynomolgus (His) S100-A9; Calgranulin-B; Calprotectin L1H subunit; MRP-14; p14; CAGB; MRP14	Cynomolgus	E. coli
	The S100A9 protein is a calcium and zinc binder that plays a critical regulatory role in inflammation and immune responses. Its diverse functions include induction of neutrophil chemotaxis, adhesion, enhanced bactericidal activity through SYK, PI3K/AKT and ERK1/2 activation, and promotion of phagocytosis. S100A9 Protein, Cynomolgus (His) is the recombinant cynomolgus-derived S100A9 protein, expressed by E. coli , with N-His labeled tag.

HY-P74583

	S100A9 Protein, Mouse (His) Maximum Cited Publications 8 Publications Verification Protein S100-A9; Calgranulin-B; MRP-14; CAGB; CFAG	Mouse	E. coli
	S100A9 Protein is a calcium- and zinc-binding protein which belongs to the S100 family that primarily expresses in neutrophils and monocytes.S100A9 can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2.S100A9 has pro-inflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities which plays an important role in the regulation of inflammatory processes and immune response.S100A9 Protein, Mouse (His) is the recombinant mouse-derived S100A9 protein, expressed by E.coli , with N-6*His labeled tag.

HY-P76587

	S100A9 Protein, Human (sf9, His) Protein S100-A9; Calgranulin-B; MRP-14; CAGB; CFAG	Human	Sf9 insect cells
	The S100A9 protein is a calcium and zinc binder that plays a critical regulatory role in inflammation and immune responses. Its diverse functions include induction of neutrophil chemotaxis, adhesion, enhanced bactericidal activity through SYK, PI3K/AKT and ERK1/2 activation, and promotion of phagocytosis. S100A9 Protein, Human (sf9, His) is the recombinant human-derived S100A9 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P70532

	S100A9 Protein, Human 1 Publications Verification Protein S100-A9; Calgranulin-B; Calprotectin L1H subunit; Leukocyte L1 complex heavy chain; MRP-14; CAGB; CFAG	Human	E. coli
	S100A9 Protein is an acidic protein. S100A9 Protein activates pro-inflammatory signaling pathways by binding to TLR4/MD2 and RAGE receptors, regulating transcription factors such as NF-κB, CREB-1, STAT3/STAT5, etc. S100A9 Protein forms a heterodimer (calprotectin) with S100A8. S100A9 Protein enhances cytokine secretion under inflammatory stimulation, promotes immune cell migration, regulates vascular endothelial permeability, induces tumor cell apoptosis, and exerts antibacterial effects through metal ion chelation.

HY-P70532A

	S100A9 Protein, Human (His) Protein S100-A9; Calgranulin-B; Calprotectin L1H subunit; Leukocyte L1 complex heavy chain; MRP-14; CAGB; CFAG	Human	E. coli
	The S100A9 protein is a calcium and zinc binder that plays a critical regulatory role in inflammation and immune responses. Its diverse functions include induction of neutrophil chemotaxis, adhesion, enhanced bactericidal activity through SYK, PI3K/AKT and ERK1/2 activation, and promotion of phagocytosis. S100A9 Protein, Human (His) is the recombinant human-derived S100A9 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P7S1354

	S100A9 Protein, Rat (His) Calgranulin-B; Migration inhibitory factor-related protein 14 (MRP-14; p14); Myeloid-related protein 14; S100 calcium-binding protein A9; Mrp14	Rat	E. coli

HY-P705438

	*S100A8-S100A9* Heterodimer Protein, Mouse (His)** S100A8-s100a9	Mouse	E. coli
	S100A8, composed of calcium- and zinc-bound S100A8, plays a crucial regulatory role in inflammation and immune responses. As a calprotectin, it contributes to leukocyte function, regulates the cytoskeleton, and activates intracellular NADPH oxidase. The S100A8-S100A9 Heterodimer Protein, Mouse (His), is a recombinant protein dimer complex containing the S100A8-S100A9 heterodimer protein, expressed by E.coli and tagged with His.

HY-P71076

	*S100A8-S100A9* Heterodimer Protein, Human (His, solution)** 1 Publications Verification S100A8/s100a9 Heterodimer	Human	E. coli
	S100A8 consists of calcium and zinc bound S100A8, which plays a critical regulatory role in inflammation and immune responses. As calprotectin, it contributes to leukocyte function, regulates the cytoskeleton, and activates intracellular NADPH oxidase. S100A8-S100A9 Heterodimer Protein, Human (His, solution) is a recombinant protein dimer complex containing human-derived S100A8-S100A9 Heterodimer protein, expressed by E. coli , with C-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-100442S1

Paquinimod-d5-1
Paquinimod-d5-1 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of *S100A8/S100A9*. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .

HY-10528S

Tasquinimod-d3
Tasquinimod-d3 (ABR-215050-d3) is the deuterium labeled Tasquinimod (HY-10528). Tasquinimod is an oral antiangiogenic agent, which plays an important role in castration-resistant prostate cancer. Tasquinimod binds to the regulatory Zn ²⁺ binding domain of HDAC4 with K_d of 10-30 nM. Tasquinimod also is a *S100A9* inhibitor .

HY-100442S

Paquinimod-d5
Paquinimod-d5 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of *S100A8/S100A9*. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .

Host:	Mouse (2) Rabbit (1)
Reactivity:	Human (3)
Application:	IHC-P (3) mIHC (1) IF-Tissue (1) WB (1) FC (2) ELISA (2)
Isotype:	IgG (1) IgG1 (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83974

	S100A9 Antibody (YA3671) MIF; NIF; P14; CAGB; CFAG; CGLB; L1AG; LIAG; MRP14; 60B8AG; MAC387	IHC-P, FC, ELISA	Human
	S100A9 Antibody (YA3671) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to S100A9.

HY-P83974A

	S100A9 Antibody (YA3671)(PBS only) MIF; NIF; P14; CAGB; CFAG; CGLB; L1AG; LIAG; MRP14; 60B8AG; MAC387	IHC-P, FC, ELISA	Human
	S100A9 Antibody (YA3671) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to S100A9.

HY-P83734

	S100A9 Antibody(YA3464) Leukocyte L1 complex heavy chain antibody; 60B8AG antibody; CAGB antibody; Calgranulin B antibody; Calgranulin-B antibody; Calprotectin L1H subunit antibody; CFAG antibody; CGLB antibody; Cystic fibrosis antigen B antibody; L1AG antibody; Leukocyte L1 complex heavy chain antibody; LIAG antibody; MAC387 antibody; MIF antibody; Migration inhibitory factor related protein 14 antibody; Migration inhibitory factor-related protein 14 antibody; MRP 14 antibody; MRP-14 antibody; MRP14 antibody; Myeloid-related protein 14 antibody; NIF antibody; OTTHUMP00000015331 antibody; p14 antibody; Protein S100-A9 antibody; S100 A9 antibody; S100 calcium binding protein A9 antibody; S100 calcium binding protein A9 calgranulin B antibody; S100 calcium-binding protein A9 antibody; s100a9 antibody; S10A9_HUMAN antibody;	WB, IHC-P, IF-Tissue, mIHC	Human
	S100A9 Antibody(YA3464) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to S100A9.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS12386

S100A9 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
S100A9 Human Pre-designed siRNA Set A contains three designed siRNAs for S100A9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16579

S100a9 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
S100a9 Mouse Pre-designed siRNA Set A contains three designed siRNAs for S100a9 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23013

S100a9 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
S100a9 Rat Pre-designed siRNA Set A contains three designed siRNAs for S100a9 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides