Search Result

Results for "

shock

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HSP (51) Adrenergic Receptor (5) Antibiotic (8) Apoptosis (13) Autophagy (7) Bacterial (14) Bcl-2 Family (1) Beta-lactamase (1) Biochemical Assay Reagents (2) CaSR (2) COX (2) Dengue virus (1) Deubiquitinase (1) DNA/RNA Synthesis (2) Drug Metabolite (1) Endogenous Metabolite (5) Eukaryotic Initiation Factor (eIF) (1) Flavivirus (1) Fluorescent Dye (4) Fungal (1) GABA Receptor (1) HDAC (2) Hedgehog (1) Histamine Receptor (1) HMG-CoA Reductase (HMGCR) (6) HSV (1) IFNAR (1) IKK (1) Influenza Virus (2) Integrin (1) Interleukin Related (1) IRE1 (1) Isotope-Labeled Compounds (1) JNK (1) Liposome (1) Melanocortin Receptor (3) MicroRNA (1) Monoamine Oxidase (1) NF-κB (1) NO Synthase (6) NOD-like Receptor (NLR) (2) Orthopoxvirus (2) p38 MAPK (2) Parasite (3) PGE synthase (1) PKC (1) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (8) Pyroptosis (3) Reactive Oxygen Species (1) SARS-CoV (2) Sirtuin (1) TGF-beta/Smad (1) TNF Receptor (2) Toll-like Receptor (TLR) (3) Vasopressin Receptor (5)
By Research Areas:	Cancer (52) Cardiovascular Disease (28) Endocrinology (7) Infection (22) Inflammation/Immunology (34) Metabolic Disease (19) Neurological Disease (18)

By Targets:

HSP (51)

Adrenergic Receptor (5)

Antibiotic (8)

Apoptosis (13)

Autophagy (7)

Bacterial (14)

Bcl-2 Family (1)

Beta-lactamase (1)

Biochemical Assay Reagents (2)

CaSR (2)

COX (2)

Dengue virus (1)

Deubiquitinase (1)

DNA/RNA Synthesis (2)

Drug Metabolite (1)

Endogenous Metabolite (5)

Eukaryotic Initiation Factor (eIF) (1)

Flavivirus (1)

Fluorescent Dye (4)

Fungal (1)

GABA Receptor (1)

HDAC (2)

Hedgehog (1)

Histamine Receptor (1)

HMG-CoA Reductase (HMGCR) (6)

HSV (1)

IFNAR (1)

IKK (1)

Influenza Virus (2)

Integrin (1)

Interleukin Related (1)

IRE1 (1)

Isotope-Labeled Compounds (1)

JNK (1)

Liposome (1)

Melanocortin Receptor (3)

MicroRNA (1)

Monoamine Oxidase (1)

NF-κB (1)

NO Synthase (6)

NOD-like Receptor (NLR) (2)

Orthopoxvirus (2)

p38 MAPK (2)

Parasite (3)

PGE synthase (1)

PKC (1)

Platelet-activating Factor Receptor (PAFR) (1)

Potassium Channel (8)

Pyroptosis (3)

Reactive Oxygen Species (1)

SARS-CoV (2)

Sirtuin (1)

TGF-beta/Smad (1)

TNF Receptor (2)

Toll-like Receptor (TLR) (3)

Vasopressin Receptor (5)

By Research Areas:

Cancer (52)

Cardiovascular Disease (28)

Endocrinology (7)

Infection (22)

Inflammation/Immunology (34)

Metabolic Disease (19)

Neurological Disease (18)

132

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: HSP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-79457

S-Methylisothiourea sulfate 1 Publications Verification	NO Synthase HSV	Infection Inflammation/Immunology
S-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of inducible nitric oxide synthase (iNOS). S-Methylisothiourea sulfate exerts beneficial effects in rodent models of septic shock .

HY-144867

CCT245232	HSP	Cancer
CCT245232 is a potent inhibitor of heat shock factor 1 (HSF1). HSF1 is the master regulator of the heat shock response, in which multiple genes are induced in response to temperature increase and other stresses. CCT245232 has the potential for the research of proliferative diseases, such as cancer (extracted from patent WO2015049535A1) .

HY-106690

Centhaquin Centhaquine; PMZ-2010	Others	Cardiovascular Disease Inflammation/Immunology
Centhaquine (Centhaquin; PMZ-2010) is a novel agent has the potential for treatment of haemorrhagic shock. Centhaquine (Centhaquin; PMZ-2010) can augment cardiac output, reduce systemic vascular resistance in haemorrhagic models .

HY-P4984

*Toxic Shock* Syndrome Toxin-1 (TSST-1) (58-78)**	Biochemical Assay Reagents	Inflammation/Immunology Cancer
Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) is a T cell proliferation activator. Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) promotes the in vitro proliferation of human peripheral blood mononuclear cells (PBMC) in a dose-dependent manner. Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) can be used in research on inflammatory and immunity, as well as cancer .

HY-144830

6BrCaQ	HSP	Cancer
6BrCaQ is a potent *mitochondrial heat shock* protein TRAP1** inhibitor, with antiproliferative activity. 6BrCaQ can be used in the synthesis of 6BrCaQ-TPP conjugates .

HY-125974

HM03

2 Publications Verification

HSP Cancer

HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity .

HM03 2 Publications Verification	HSP	Cancer
HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity .

HY-125974A

HM03 trihydrochloride	HSP	Cancer
HM03 trihydrochloride is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 trihydrochloride has anticancer activity .

HY-163035

EM-163	TNF Receptor IFNAR	Inflammation/Immunology
EM-163 is a summative BB-Loop analog. EM-163 can alleviate inflammation and prevent death from toxic shock by targeting the TIR domain of MyD88. EM-163 can be used in the study of SEB poisoning (SEB: Staphylococcal enterotoxin B) .

HY-W014102

L-Alanyl-L-glutamine	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations .

HY-115447

Clobenpropit	Histamine Receptor	Neurological Disease
Clobenpropit is a potent histamine H3-receptor antagonist. Clobenpropit decreases dopamine release and increases histamine levels in the hypothalamus. Clobenpropit shows antipsychotic-like activities. Clobenpropit causes a resuscitating effect in rats subjected to the hemorrhagic shock .

HY-P99177

Enibarcimab	SARS-CoV	Infection Cardiovascular Disease
Enibarcimab is a humanised murine monoclonal immunoglobulin G1 (IgG1) antibody, could be used for acute heart failure, COVID-19 infections and septic shock research .

HY-18734A

Carboxy-PTIO potassium 3 Publications Verification	NO Synthase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Carboxy-PTIO potassium is a potent nitric oxide (NO) scavenger that can make a quick reaction with NO to produce NO₂. Carboxy-PTIO potassium can prevent hypotension and endotoxic shock through the direct scavenging action against NO in lipopolysaccharide-stimulated rat model .

HY-18734

Carboxy-PTIO	NO Synthase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Carboxy-PTIO is a potent nitric oxide (NO) scavenger that can make a quick reaction with NO to produce NO₂. Carboxy-PTIO can prevent hypotension and endotoxic shock through the direct scavenging action against NO in lipopolysaccharide-stimulated rat model .

HY-156374

D359-0396	NOD-like Receptor (NLR) Pyroptosis	Inflammation/Immunology
D359-0396 is an orally active NLRP3 inflammasome inhibitor. D359-0396 inhibits pyroptosis and IL-1β release in macrophages. D359-0396 also inhibits the oligomerization of NLRP3, ASC and the cleavage of GSDMD. D359-0396 alleviates EAE, and also improves survival after septic shock in mice .

HY-149891

HSP90-IN-23	HSP	Cancer
HSP90-IN-23 (Comp 12-1) is an inhibitor of *heat shock* protein 90(HSP90) with an IC₅₀** of 9 nM. HSP90-IN-23 induces apoptosis of tumor cells and arrests the tumor cell cycle in G0/G1 phase. HSP90-IN-23 can be used for cancer research .

HY-108486

Herbimycin A	Bacterial Antibiotic	Infection
Herbimycin A, an ansamycin antibiotic, acts as a Src family kinase inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60 ^v-src and p210 ^BCR-ABL Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro.

HY-108295

Pivagabine CXB-722	GABA Receptor	Neurological Disease
Pivagabine (CXB 722) is a hydrophobic 4-aminobutyric acid derivative with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain .

HY-18669

ML346 3 Publications Verification	HSP	Cancer
ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC₅₀ of 4.6 μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27 .

HY-P99891

Rovelizumab	Integrin	Cardiovascular Disease
Rovelizumab is a humanized monoclonal leukointegrin antibody. Rovelizumab is a monoclonal antibody directed against the CD11/CD18 cell adhesion proteins. Rovelizumab can be used for research of multiple sclerosis (MS), hemorrhagic shock, myocardial infarction (MI) and stroke .

HY-107599

AEG3482	JNK Apoptosis	Neurological Disease
AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25 .

HY-P1208

PG-931	Melanocortin Receptor	Inflammation/Immunology
PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R (IC₅₀=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-152027

HSP90-IN-18	HSP Apoptosis	Infection Neurological Disease Inflammation/Immunology Cancer
HSP90-IN-18 is an effective *heat shock* protein 90 (Hsp90) inhibitor. HSP90-IN-18 has effective Hsp90 inhibitory activity with an IC₅₀** value of 0.39 μM. HSP90-IN-18 can be used for the research of viral infection, neurodegenerative disease, and inflammation .

HY-152028

HSP90-IN-19	HSP	Infection Neurological Disease Inflammation/Immunology Cancer
HSP90-IN-19 is an effective *heat shock* protein 90 (Hsp90) inhibitor. HSP90-IN-19 has effective Hsp90 inhibitory activity with an IC₅₀** value of 0.27 μM. HSP90-IN-19 can be used for the research of viral infection, neurodegenerative disease, and inflammation .

HY-138454

MEG hemisulfate Mercaptoethylguanidine hemisulfate	NO Synthase	Inflammation/Immunology
MEG (Mercaptoethylguanidine) hemisulfate is a potent and selective inhibitor of the inducible NO synthase (iNOS), with EC₅₀s of 11.5, 110, and 60 μM for iNOS, ecNOS, and bNOS respectively in tissue homogenates. MEG hemisulfate is also a potent scavenger of peroxynitrite and inhibits peroxynitrite-induced oxidative processes. MEG hemisulfate has a protective effect in many experimental models of inflammation, including ischemia/reperfusion injury, periodontitis, hemorrhagic shock, inflammatory bowel disease, and endotoxic and septic shock .

HY-118487

OB-24	Others	Cancer
OB-24 is a potent inhibitor of heme oxygenase-1 (HO-1). Heme oxygenase-1, a member of the heat shock protein family, plays a key role as a sensor and regulator of oxidative stress. OB-24 significantly inhibited cell proliferation in vitro and tumor growth and lymph node/lung metastases in vivo. OB-24 has potential for the research of advanced prostate cancer (PCA) .

HY-P1208A

PG-931 TFA	Melanocortin Receptor	Inflammation/Immunology
PG-931 TFA, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R(IC₅₀=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-145559

Cemdomespib KU-596	HSP	Metabolic Disease
Cemdomespib (KU-596) is a highly bioavailable second-generation Hsp90 modulator. Cemdomespib has shown efficacy in improving sensory deficits in models of diabetic peripheral neuropathy. Cemdomespib induces Hsp70 levels and manifest neuroprotective activity through induction of the heat shock response .

HY-13479

EC144	HSP	Cancer
EC144 is a potent and selective inhibitor of heat shock protein 90 (Hsp90) with an IC₅₀ of 1.1 nM. EC144 inhibits tumor growth and causes partial tumor regressions. EC144 has the potential for the research of cancer diseases . EC144 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-146723

IKKβ-IN-1	IKK	Inflammation/Immunology
IKKβ-IN-1 is a potent and orally active IkappaB (IKK-β) inhibitor with IC₅₀ of 0.20 μM. IKKβ-IN-1 can reduce PGE₂ and TNF-α production in mouse macrophage cells. IKKβ-IN-1 has the ability to protect mice against septic shock induced mortality .

HY-P3434

Ac-FEID-CMK	Pyroptosis	Inflammation/Immunology
Ac-FEID-CMK is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK can suppress the caspy2-mediated noncanonical inflammasome pathway .

HY-103320

Calhex 231	CaSR	Metabolic Disease
Calhex 231 is a potent negative allosteric modulator that blocks (IC₅₀ = 0.39 μM) increases in [ ³H]inositol phosphates elicited by activating the human wild-type CaSR transiently Ca ²⁺-sensing receptor. Calhex 231 can be used in the study of traumatic hemorrhagic shock (THS) and diabetic cardiomyopathy (DCM) .

HY-P3434A

Ac-FEID-CMK TFA	Pyroptosis	Inflammation/Immunology
Ac-FEID-CMK TFA is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK TFA can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK TFA inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK TFA can suppress the caspy2-mediated noncanonical inflammasome pathway .

HY-N0584B

Anisodamine hydrochloride 6-Hydroxyhyoscyamine hydrochloride	Adrenergic Receptor	Inflammation/Immunology
Anisodamine hydrochloride is an anticholinergic and α1 adrenergic receptor antagonist. Anisodamine hydrochloride can be used for improving blood flow in circulatory disorders such as septic shock, Anisodamine hydrochloride displays a spectrum of pharmacological effects similar to Atropine (HY-B1205) and Sopolamine (HY-B2065) including inhibition of salivation, gastrointestinal and sweat secretion, gastrointestinal motility, respiratory secretion and urinary bladder contraction in vivo .

HY-N8267

Territrem A

Others Others

Territrem A is a shock-causing mycotoxin isolated from Aspergillus terreus .
HY-B0779

Teprenone

3 Publications Verification

Geranylgeranylacetone
HSP Neurological Disease Cancer

Teprenone is an anti-ulcer agent, and works as an inducer of heat shock proteins (HSPs).
HY-U00398

Bimoclomol

HSP Cardiovascular Disease

Bimoclomol is a heat shock protein (HSP) coinducer, used for treatment of cardiovascular diseases.
HY-13313

XL888

2 Publications Verification

HSP Cancer

XL888 is a heat shock protein-90 (HSP90) inhibitor, with an IC₅₀ of 24 nM.
HY-100872

KRIBB11

15+ Cited Publications

HSP Apoptosis Cancer

KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC₅₀ of 1.2 μM.
HY-100110

KNK437

2 Publications Verification

Heat shock Protein Inhibitor I
HSP Cancer

KNK437 is a HSP inhibitor, and inhibits the induction of HSP105, HSP70, and HSP40.
HY-N10604

Dihydromaniwamycin E

Influenza Virus SARS-CoV Infection

Dihydromaniwamycin E is a heat-shock metabolite with antiviral activity against influenza and SARS-CoV-2 viruses .

Territrem A	Others	Others
Territrem A is a shock-causing mycotoxin isolated from Aspergillus terreus .

Teprenone 3 Publications Verification Geranylgeranylacetone	HSP	Neurological Disease Cancer
Teprenone is an anti-ulcer agent, and works as an inducer of heat shock proteins (HSPs).

Bimoclomol	HSP	Cardiovascular Disease
Bimoclomol is a *heat shock* protein (HSP)** coinducer, used for treatment of cardiovascular diseases.

XL888 2 Publications Verification	HSP	Cancer
XL888 is a heat shock protein-90 (HSP90) inhibitor, with an IC₅₀ of 24 nM.

KRIBB11 15+ Cited Publications	HSP Apoptosis	Cancer
KRIBB11 is an inhibitor of *Heat shock* factor 1 (HSF1), with IC₅₀** of 1.2 μM.

KNK437 2 Publications Verification Heat shock Protein Inhibitor I	HSP	Cancer
KNK437 is a HSP inhibitor, and inhibits the induction of HSP105, HSP70, and HSP40.

Dihydromaniwamycin E	Influenza Virus SARS-CoV	Infection
Dihydromaniwamycin E is a heat-shock metabolite with antiviral activity against influenza and SARS-CoV-2 viruses .

HY-N0512

Loganin 2 Publications Verification Loganoside	Apoptosis	Cancer
Loganin, a major iridoid glycoside obtained from Corni fructus, has been shown to have anti-inflammatory and anti-shock effects.

HY-B0459

Scopine 6,7-Epoxytropine	Adrenergic Receptor	Neurological Disease Endocrinology
Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.

HY-B1425

Ethoxyquin

HSP Reactive Oxygen Species Cancer

Ethoxyquin is an antioxidant which has been used in animal feed for many years and also an inhibitor of heat shock protein 90 (Hsp90).

Ethoxyquin	HSP Reactive Oxygen Species	Cancer
Ethoxyquin is an antioxidant which has been used in animal feed for many years and also an inhibitor of *heat shock* protein 90 (Hsp90**).

HY-105239A

Selepressin acetate FE 202158 acetate	Vasopressin Receptor	Cardiovascular Disease
Selepressin (FE 202158) acetate is a selective vasopressin V_1A receptor agonist. Selepressin acetate is a potent vasopressin. Selepressin acetate can be used in the study of septic shock.

HY-12622

HSP70-IN-1

1 Publications Verification

HSP Cancer

HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC₅₀ of 2.3 μM.

HSP70-IN-1 1 Publications Verification	HSP	Cancer
HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC₅₀ of 2.3 μM.

HY-160099

5,14-HEDGE	Others	Cardiovascular Disease
5,14-HEDGE, a 20-HETE mimetic, prevents vascular hyporeactivity, hypotension, tachycardia, inflammation, and mortality in a rodent model of septic shock .

HY-105239

Selepressin FE 202158	Vasopressin Receptor	Cardiovascular Disease
Selepressin (FE 202158) is a selective vasopressin V_1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock .

HY-B0459A

Scopine hydrochloride 6,7-Epoxytropine hydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology
Scopine hydrochloride (6,7-Epoxytropine hydrochloride) is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.

HY-132995

DP-1	Drug Metabolite	Others
DP-1, a degradation product of SDC-TRAP-0063, is a fragment of Ganetespib. Ganetespib is a heat shock protein 90 (HSP90) inhibitor with anti-tumor activity .

HY-145927

NXP800

CCT361814
HSP Cancer

NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 has the potential for cancer research .

Cat. No.	Product Name	Type

HY-128868

FITC-Dextran (MW 10000)

Maximum Cited Publications

28 Publications Verification

Fluorescent Dyes/Probes

FITC-Dextran (MW 10000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 10000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 10000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .

HY-128868A

FITC-Dextran (MW 4000)

Maximum Cited Publications

28 Publications Verification

Fluorescent Dyes/Probes

FITC-Dextran (MW 4000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 4000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 4000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .

HY-128868D

FITC-Dextran (MW 40000)

1 Publications Verification

Fluorescent Dyes/Probes

FITC-Dextran (MW 40000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 40000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 40000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .

HY-128868G

FITC-Dextran (MW 150000)

Fluorescent Dyes/Probes

FITC-Dextran (MW 150000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=491 nm; Em=518 nm). FITC-Dextran (MW 150000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 150000) can be used in perfusion studies in animals or in fluorescence microlymphography, to study processes that affect the permeability of the blood brain barrier (BBB) . FITC-Dextran (MW 150000) can be used as fluorescent probe to study cell permeability .

HY-128868B

FITC-Dextran (MW 3000-5000)

Dyes

FITC-Dextran (MW 3000-5000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 3000-5000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 3000-5000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption . Storage: protect from light.

Cat. No.	Product Name	Target	Research Area

HY-W014102

L-Alanyl-L-glutamine	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations .

HY-P1208

PG-931	Melanocortin Receptor	Inflammation/Immunology
PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R (IC₅₀=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-P4984

*Toxic Shock* Syndrome Toxin-1 (TSST-1) (58-78)**	Biochemical Assay Reagents	Inflammation/Immunology Cancer
Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) is a T cell proliferation activator. Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) promotes the in vitro proliferation of human peripheral blood mononuclear cells (PBMC) in a dose-dependent manner. Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) can be used in research on inflammatory and immunity, as well as cancer .

HY-P3068

ACTH (1-16) (human) Adrenocorticotropic hormone (1-16)	Peptides	Cardiovascular Disease
ACTH (1-16) (human) (Adrenocorticotropic hormone (1-16)) is an ACTH fragment. ACTH (1-16) (human) improves cardiovascular function and survival in experimental hemorrhagic shock .

HY-P1208A

PG-931 TFA	Melanocortin Receptor	Inflammation/Immunology
PG-931 TFA, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R(IC₅₀=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-P3434

Ac-FEID-CMK	Pyroptosis	Inflammation/Immunology
Ac-FEID-CMK is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK can suppress the caspy2-mediated noncanonical inflammasome pathway .

HY-P3434A

Ac-FEID-CMK TFA	Pyroptosis	Inflammation/Immunology
Ac-FEID-CMK TFA is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK TFA can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK TFA inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK TFA can suppress the caspy2-mediated noncanonical inflammasome pathway .

HY-105239A

Selepressin acetate FE 202158 acetate	Vasopressin Receptor	Cardiovascular Disease
Selepressin (FE 202158) acetate is a selective vasopressin V_1A receptor agonist. Selepressin acetate is a potent vasopressin. Selepressin acetate can be used in the study of septic shock.

HY-105239

Selepressin FE 202158	Vasopressin Receptor	Cardiovascular Disease
Selepressin (FE 202158) is a selective vasopressin V_1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock .

HY-P5236

Acetyl tetrapeptide-22

Peptides Others

Acetyl tetrapeptide-22 is a bioactive peptide with repair skin effect and has been reported used as a cosmetic ingredient .

HY-12554A

Terlipressin diacetate 1 Publications Verification	Vasopressin Receptor	Cardiovascular Disease Inflammation/Immunology Endocrinology
Terlipressin diacetate is a vasopressin analogue with potent vasoactive properties. Terlipressin diacetate is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin diacetate exerts anti-inflammatory and anti-oxidative effects. Terlipressin diacetate has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research .

HY-12554B

Terlipressin acetate	Vasopressin Receptor	Cardiovascular Disease Inflammation/Immunology Endocrinology
Terlipressin acetate is a vasopressin analogue with potent vasoactive properties. Terlipressin acetate is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin acetate exerts anti-inflammatory and anti-oxidative effects. Terlipressin acetate has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research .

HY-106275

FX-06 Fibrin-derived peptide Bβ15-42	Flavivirus Dengue virus	Cardiovascular Disease
FX-06 (Fibrin-derived peptide Bβ15-42) is a fibrin Bbeta chain-derived peptide. FX-06 binds to VE-cadherin and inhibits leukocyte transmigration and initiates VE-cadherin-mediated signaling. FX-06 can be used in the research of ischemia/reperfusion injury, Dengue shock syndrome (DSS) .

HY-P10186

Myristoylated ARF6 (2-13), scrambled	Peptides	Cardiovascular Disease
Myristoylated ARF6 (2-13), scrambled?is a peptide , and is composed of amino acids 2–13 of ARF6 (MyrARF6 2–13) .

HY-P2242A

RO27-3225 TFA	Melanocortin Receptor	Neurological Disease Inflammation/Immunology
RO27-3225 TFA is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC₅₀ of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R. RO27-3225 TFA has neuroprotective and anti-inflammatory effects .

HY-105088

Pexiganan MSI 78 free base	Bacterial	Infection
Pexiganan (MSI 78 free base) is a synthetic analog of magainin 2. Pexiganan is a potent and orally active broad-spectrum antimicrobial peptide. Pexiganan can be used in the research of infections, such as diabetic foot ulcer infections .

HY-P2317A

Cecropin P1, porcine acetate	Bacterial Endogenous Metabolite	Infection
Cecropin P1, porcine acetate is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine acetate shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine acetate shows antiviral activity and inhibits PRRSV infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W014102

L-Alanyl-L-glutamine	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations .

HY-108486

Herbimycin A	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Benzene Quinones Disease Research Fields	Bacterial Antibiotic
Herbimycin A, an ansamycin antibiotic, acts as a Src family kinase inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60 ^v-src and p210 ^BCR-ABL Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro.

HY-N0584B

Anisodamine hydrochloride 6-Hydroxyhyoscyamine hydrochloride	Structural Classification Alkaloids Pyrrole Alkaloids Anisodus tanguticus (Maxinowicz) Pascher Source classification Plants Solanaceae	Adrenergic Receptor
Anisodamine hydrochloride is an anticholinergic and α1 adrenergic receptor antagonist. Anisodamine hydrochloride can be used for improving blood flow in circulatory disorders such as septic shock, Anisodamine hydrochloride displays a spectrum of pharmacological effects similar to Atropine (HY-B1205) and Sopolamine (HY-B2065) including inhibition of salivation, gastrointestinal and sweat secretion, gastrointestinal motility, respiratory secretion and urinary bladder contraction in vivo .

HY-N8267

Territrem A

Structural Classification Natural Products Microorganisms Source classification

Others

Territrem A is a shock-causing mycotoxin isolated from Aspergillus terreus .

HY-N10604

Dihydromaniwamycin E	Natural Products Microorganisms	Influenza Virus SARS-CoV
Dihydromaniwamycin E is a heat-shock metabolite with antiviral activity against influenza and SARS-CoV-2 viruses .

HY-N0512

Loganin 2 Publications Verification Loganoside	Structural Classification Iridoids Classification of Application Fields Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants Disease Research Fields Cancer	Apoptosis
Loganin, a major iridoid glycoside obtained from Corni fructus, has been shown to have anti-inflammatory and anti-shock effects.

HY-B0459

Scopine 6,7-Epoxytropine	Alkaloids Classification of Application Fields Neurological Disease Datura stramonium L. Source classification Plants Solanaceae Disease Research Fields Endocrinology	Adrenergic Receptor
Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.

HY-N6850

Calenduloside E 1 Publications Verification	Triterpenes other families Classification of Application Fields Terpenoids Source classification Other Diseases Aralia elata (Miq.) Seem. Plants Endogenous metabolite Disease Research Fields Araliaceae	HSP Endogenous Metabolite
Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has anti-apoptotic potent by targeting heat shock protein 90 (Hsp90) .

HY-N3866

Esculentic acid	Triterpenes Structural Classification Terpenoids Labiatae Source classification Plants Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	COX
Esculentic acid is a selective COX-2 inhibitor and has anti-inflammatory effect. Esculentic acid is a pentacyclic triterpenoid that can be extracted from the Chinese herb Phytolacca esculenta .

HY-N6679A

10,11-Dehydrocurvularin	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Phenols Polyphenols Disease Research Anticancer Disease Research Fields	HSP TGF-beta/Smad
10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the *heat shock* response. 10,11-Dehydrocurvularin inhibits TGF-β signalling** pathway. Anti-tumorous activity .

HY-N10352

4-epi-Withaferin A	Classification of Application Fields Source classification Withania somnifera Plants Solanaceae Disease Research Fields Steroids Cancer	Others
4-epi-Withaferin A (compound 28) is the analogue of Withaferin A. 4-epi-Withaferin A enhances cytotoxicity and cytoprotective heat-shock-inducing activity (HSA). 4-epi-Withaferin A has the potential for the research of protein aggregation-associated diseases by stimulating cellular defense mechanisms .

HY-B0425A

Novobiocin sodium 5 Publications Verification Albamycin sodium; Cathomycin sodium	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Classification of Application Fields Antibiotics Source classification Antiviral Antibacterial Disease Research Disease Research Fields Other Antibiotics Cancer	Bacterial Antibiotic Orthopoxvirus Apoptosis DNA/RNA Synthesis HSP
Novobiocin (Albamycin) sodium is a potent and orally active antibiotic. Novobiocin sodium also is a DNA gyrase inhibitor and a *heat shock* protein 90 (Hsp90)** antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity .

HY-N0293

Paeoniflorin 15+ Cited Publications Peoniflorin	Structural Classification Other Monoterpenes Paeonia lactiflora Pall. Terpenoids Source classification Plants Paeoniaceae	HSP
Paeoniflorin is a *heat shock* protein*-inducing compound and commonly exists in the plants of Paeoniaceae* family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity .

HY-N6712

Thiolutin 2 Publications Verification Acetopyrrothin	Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Metabolic Disease Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic Endogenous Metabolite Deubiquitinase
Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36 . Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation .

HY-19356

Rocaglamide Maximum Cited Publications 20 Publications Verification Roc-A; MG-002	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Source classification Plants Meliaceae Disease Research Fields Aglaia elliptifolia Cancer	NF-κB HSP Eukaryotic Initiation Factor (eIF)
Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective *heat shock* factor 1 (HSF1) activation inhibitor with an IC₅₀** of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia .

HY-N2359

Chelerythrine	Alkaloids Structural Classification Classification of Application Fields Source classification Metabolic Disease Macleaya cordata (Willd.) R. Br. Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Papaveraceae	Beta-lactamase PKC Bcl-2 Family Apoptosis Autophagy
Chelerythrine is a natural alkaloid, acts as a potent and selective Ca ²⁺/phospholopid-dependent PKC antagonist, with an IC₅₀ of 0.7 μM . Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity . Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy .

HY-105088

Pexiganan MSI 78 free base	Infection Structural Classification Natural Products Animals Classification of Application Fields Source classification Disease Research Fields	Bacterial
Pexiganan (MSI 78 free base) is a synthetic analog of magainin 2. Pexiganan is a potent and orally active broad-spectrum antimicrobial peptide. Pexiganan can be used in the research of infections, such as diabetic foot ulcer infections .

HY-N6769

Radicicol 3 Publications Verification Monorden	Structural Classification Antifungal Classification of Application Fields Source classification Marine natural products Anti-parasitic Disease Research Infection Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Disease Research Fields Marine microorganism	HSP Bacterial Antibiotic Parasite
Radicicol is an inhibitor of Hsp90 with an IC₅₀ value < 1 μM, and leads to proteasomal degradation . Radicicol exhibits inhibition on PDK with IC₅₀s of 230 μM (PDK1) and 400 μM (PDK3). Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB . Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO), with an IC₅₀ value of 16.04 μM .

Species:	Human (22) Mouse (2) E.coli (2) Staphylococcus aureus (1)
Tag:	His (24) SUMO (2) Tag Free (2) GST (2)
Source:	HEK293 (2) P. pastoris (1) Sf9 insect cells (2) E. coli (23)

Cat. No.	Compare	Product Name	Species	Source

HY-P701385

	HSPA2 Protein, Human (His) HSPA2; Heat shock-related 70 kDa protein 2; Heat shock 70 kDa protein 2	Human	E. coli
	The HSPA2 protein is a molecular chaperone that protects the proteome, aids in protein folding and transport, activates proteolysis, and regulates protein complex formation. It ensures accurate protein folding and degradation, with substrate affinity related to its nucleotide status. HSPA2 Protein, Human (His) is the recombinant human-derived HSPA2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HSPA2 Protein, Human (His) is 638 a.a., .

HY-P71824

	HSP70/DnaK Protein, E. coli (P.pastoris, His) dnaK; HSP70; Heat shock 70kDa protein; Heat shock protein 70	E.coli	P. pastoris
	HSP70/DnaK protein, a molecular chaperone, responds primarily to stress, notably heat shock. It plays a crucial role in aiding the proper folding of proteins during cellular stress, preventing misfolding or aggregation. The chaperone activity is vital for cellular homeostasis and survival under adverse conditions, where maintaining correct protein conformation becomes challenging. HSP70/DnaK's ability to recognize and assist in refolding misfolded or denatured proteins is essential for cellular resilience, preventing proteotoxicity induced by stressors, especially elevated temperatures. HSP70/DnaK Protein, E. coli (P.pastoris, His) is the recombinant E. coli-derived HSP70/DnaK protein, expressed by P. pastoris, with N-6*His labeled tag. The total length of HSP70/DnaK Protein, E. coli (P.pastoris, His) is 638 a.a., with molecular weight of ~71.1 kDa.

HY-P70406

	HSF2 Protein, Human (His) rHuHeat shock factor protein 2/HSF2, His; Heat shock Factor Protein 2; HSF 2; Heat shock Transcription Factor 2; HSTF 2; HSF2; HSTF2	Human	E. coli
	As a DNA-binding protein, HSF2 protein has specific affinity for the heat shock promoter element (HSE), thereby activating transcription. Notably, in higher eukaryotes, the ability of HSF2 to bind to HSE depends on the exposure of cells to heat shock. HSF2 Protein, Human (His) is the recombinant human-derived HSF2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HSF2 Protein, Human (His) is 126 a.a., with molecular weight of ~26.0 kDa.

HY-P71487

	HtpG Protein, E.coli htpG; b0473; JW0462; Chaperone protein HtpG; Heat shock protein C62.5; Heat shock protein HtpG; High temperature protein G	E.coli	E. coli
	HtpG protein, a molecular chaperone, functions with ATPase activity and homodimerizes, demonstrating unique oligomerization at 65 degrees Celsius. HtpG Protein, E.coli is the recombinant E. coli-derived HtpG protein, expressed by E. coli , with tag free. The total length of HtpG Protein, E.coli is 624 a.a., with molecular weight of ~71.4 kDa.

HY-P72238

	HSP90AA1 Protein, Human (His-SUMO) Heat shock 86 kDa; Heat shock protein 90kDa alpha cytosolic class A member 1; Heat shock protein 90kDa alpha cytosolic class B member 1; Heat shock protein HSP 90 alpha ; Heat shock protein HSP 90 beta; Heat shock protein HSP 90-alpha; HS90A_HUMAN; HSP 84; HSP 86; Hsp 90; HSP86; HSP90A; HSP90AA1; HSP90AB1; HSP90B; HSPC1; HSPC2; HSPCAL1 ; HSPCAL4; Renal carcinoma antigen NY-REN-38	Human	E. coli
	The HSP90AA1 protein is an important molecular chaperone that coordinates the maturation and regulation of specific target proteins critical for cell cycle control and signal transduction. Its ATPase activity drives a functional cycle that induces conformational changes in client proteins for activation. HSP90AA1 Protein, Human (His-SUMO) is the recombinant human-derived HSP90AA1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of HSP90AA1 Protein, Human (His-SUMO) is 224 a.a., with molecular weight of ~43 kDa.

HY-P73105

	HSP70/HSPA1B Protein, Human (SF9, His) Heat shock 70 kDa protein 1B; HSP70-2; HSPA1B; HSP72	Human	Sf9 insect cells
	HSP70/HSPA1B protein, a vital molecular chaperone, ensures proteome integrity by protecting from stress, aiding protein folding, activating proteolysis, and regulating protein complex assembly. It maintains accurate folding through ATP cycles and co-chaperones like HSP40s, BAG1/2/3, HOPX, and STUB1. Its acetylation state modulates competitive binding with HOPX and STUB1, dictating roles in protein refolding and degradation during stress. Beyond protein homeostasis, HSP70 regulates centrosome integrity, influences SMAD3 and FOXP3 degradation, and acts as a post-attachment receptor in rotavirus A infection. HSP70/HSPA1B Protein, Human (SF9, His) is the recombinant human-derived HSP70/HSPA1B protein, expressed by Sf9 insect cells, with N-His labeled tag. The total length of HSP70/HSPA1B Protein, Human (SF9, His) is 640 a.a., with molecular weight of ~72.2 kDa.

HY-P74877

	HSP70/HSPA1A Protein, Human (HEK293, His) Heat shock 70 kDa protein 1A; HSP70-1; HSPA1A; HSP72	Human	HEK293
	The HSP70/HSPA1A protein is an important molecular chaperone that protects proteome integrity by counteracting stress, aiding protein folding, activating misfolded proteolysis, and regulating protein complex dynamics. In protein quality control systems, it ensures accurate protein folding, controls substrate targeting for degradation through the ATP cycle, and interacts with co-chaperones such as HSP40, BAG1/2/3, HOPX, and STUB1. HSP70/HSPA1A Protein, Human (HEK293, His) is the recombinant human-derived HSP70/HSPA1A protein, expressed by HEK293 , with N-His labeled tag. The total length of HSP70/HSPA1A Protein, Human (HEK293, His) is 640 a.a., with molecular weight of ~85 kDa.

HY-P71508

	TSST-1 Protein, S. aureus (His-SUMO) tst; Toxic shock syndrome toxin-1; TSST-1	Staphylococcus aureus	E. coli
	TSST-1 protein induces symptoms related to toxic shock syndrome. TSST-1 Protein, S. aureus (His-SUMO) is the recombinant Staphylococcus aureus-derived TSST-1 protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of TSST-1 Protein, S. aureus (His-SUMO) is 194 a.a., with molecular weight of ~37.9 kDa.

HY-P70844

	HSPB2 Protein, Human (His) Heat shock protein beta-2; HspB2; DMPK-binding protein; MKBP;	Human	E. coli
	HSPB2 Protein potentially regulates the kinase DMPK, enhancing its activity and influencing cellular processes. The specific mechanisms and broader implications in cellular signaling pathways require elucidation. Comprehensive studies are essential to unravel the precise molecular pathways and functional significance of the HSPB2-DMPK interplay, shedding light on its potential contributions to cellular regulation and signaling cascades. HSPB2 Protein, Human (His) is the recombinant human-derived HSPB2 protein, expressed by E. coli , with C-6*His labeled tag. The total length of HSPB2 Protein, Human (His) is 182 a.a., with molecular weight of ~22.0 kDa.

HY-P73916

	HSP60 Protein, Mouse (His) 60 kDa heat shock protein, mitochondrial; CPN60; HSP-60; HSPD1	Mouse	E. coli
	The HSP60 protein, together with Hsp10, contributes to the import and assembly of mitochondrial proteins. It ensures correct folding and prevents incorrect folding under stressful conditions. HSP60 Protein, Mouse (His) is the recombinant mouse-derived HSP60 protein, expressed by E. coli , with N-His labeled tag. The total length of HSP60 Protein, Mouse (His) is 572 a.a., with molecular weight of ~58 kDa.

HY-P73917

	HSP60 Protein, Human (His-GST) 60 kDa heat shock protein, mitochondrial; CPN60; HSP-60; HSPD1	Human	E. coli
	The HSP60 protein is a mitochondrial chaperone that facilitates protein import and assembly. HSP60 Protein, Human (His-GST) is the recombinant human-derived HSP60 protein, expressed by E. coli , with N-His, N-GST labeled tag. The total length of HSP60 Protein, Human (His-GST) is 572 a.a., with molecular weight of 52-65 kDa.

HY-P73918

	HSF1 Protein, Human (His) Heat shock factor protein 1; HSF1; HSTF 1	Human	E. coli
	HSF1, a stress-inducible transcription factor, orchestrates the heat shock response by activating heat shock genes through binding to heat shock elements (HSEs). In unstressed cells, it remains inactive in a multichaperone complex. Upon stress, HSF1 undergoes homotrimerization, binds to HSEs, and activates HSP gene transcription. It also participates in various cellular functions, including regulation of mitotic progression, repression of c-fos gene, and negative regulation of non-homologous end joining repair. Additionally, HSF1 plays a role in HIV-1 transcriptional reactivation. HSF1 Protein, Human (His) is the recombinant human-derived HSF1 protein, expressed by E. coli , with N-His, N-6*His labeled tag. The total length of HSF1 Protein, Human (His) is 528 a.a., with molecular weight of ~67 kDa.

HY-P73916A

HSP60 Protein, Mouse (N-His)

60 kDa heat shock protein, mitochondrial; CPN60; HSP-60; HSPD1
Mouse E. coli

HY-P70331

	HSP40/DNAJB1 Protein, Human (His) rHuDnaJ homolog subfamily B member 1/HSP40, His; DnaJ Homolog Subfamily B Member 1; DnaJ Protein Homolog 1; Heat shock 40 kDa Protein 1; HSP40; Heat shock Protein 40; Human DnaJ Protein 1; hDj-1; DNAJB1; DNAJ1; HDJ1; HSPF1	Human	E. coli
	HSP40/DNAJB1 protein, a key player in cellular processes, interacts with HSP70 to enhance ATPase activity and stimulate HSC70-HIP association. It negatively regulates HSF1 transcriptional activity in heat shock response recovery, and interacts with DNAJC3 and HSF1, inhibiting their transcriptional activity. These multifaceted interactions showcase HSP40/DNAJB1's intricate regulatory functions in stress responses and protein folding. HSP40/DNAJB1 Protein, Human (His) is the recombinant human-derived HSP40/DNAJB1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of HSP40/DNAJB1 Protein, Human (His) is 339 a.a., with molecular weight of ~38.0 kDa.

HY-P70116

	Cornulin Protein, Human (His) rHuCornulin, His; Cornulin; 53 kDa Putative Calcium-Binding Protein; 53 kDa Squamous Epithelial-Induced Stress Protein; 58 kDa Heat shock Protein; Squamous Epithelial Heat shock Protein 53; Tumor-Related Protein; CRNN; C1orf10; DRC1; PDRC1; SEP53	Human	E. coli
	Cornulin protein is critical in cell dynamics, promoting proliferation and promoting G1/S cell cycle progression, inducing the key regulator CCND1. It actively participates in the NFKB1 and PI3K/AKT pathways and responds to pro-inflammatory cytokines. Cornulin Protein, Human (His) is the recombinant human-derived Cornulin protein, expressed by E. coli , with N-6*His labeled tag. The total length of Cornulin Protein, Human (His) is 140 a.a., with molecular weight of ~17.0 kDa.

HY-P72051

	HSP90AA1 Protein, Sus scrofa (Baculovirus, His) HSP90AA1; HSP90A; HSPCAHeat shock protein HSP 90-alpha	Others	Sf9 insect cells
	HSP90AA1 is a molecular chaperone that regulates target proteins involved in cell cycle control and signal transduction. It interacts with co-chaperones to regulate substrate recognition and chaperone function. HSP90AA1 Protein, Sus scrofa (Baculovirus, His) is the recombinant HSP90AA1 protein, expressed by Sf9 insect cells , with N-6*His labeled tag. The total length of HSP90AA1 Protein, Sus scrofa (Baculovirus, His) is 146 a.a., with molecular weight of ~19.7 kDa.

HY-P73915

	HSPA8/HSC70 Protein, Human (His, Solution) Heat shock cognate 71 kDa protein; LAP-1; HSPA8; HSC70	Human	E. coli
	HSPA8/HSC70 is a molecular chaperone that protects the proteome and aids in peptide folding, transport, chaperone-mediated autophagy, and protein complex regulation. It is central to quality control, ensuring correct folding and targeting misfolded proteins for degradation through ATP-dependent cycles. HSPA8/HSC70 Protein, Human (His, Solution) is the recombinant human-derived HSPA8/HSC70 protein, expressed by E. coli , with N-His labeled tag. The total length of HSPA8/HSC70 Protein, Human (His, Solution) is 646 a.a., with molecular weight of ~65 kDa.

HY-P73915A

	HSPA8/HSC70 Protein, Human (N-His) Heat shock cognate 71 kDa protein; LAP-1; HSPA8; HSC70	Human	E. coli
	HSPA8/HSC70 is a molecular chaperone that protects the proteome and aids in peptide folding, transport, chaperone-mediated autophagy, and protein complex regulation. It is central to quality control, ensuring correct folding and targeting misfolded proteins for degradation through ATP-dependent cycles. HSPA8/HSC70 Protein, Human (N-His) is the recombinant human-derived HSPA8/HSC70 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HSPA8/HSC70 Protein, Human (N-His) is 646 a.a., with molecular weight of ~65 kDa.

HY-P76283

	HSP10/EPF Protein, Human (His) 1 Publications Verification 10 kDa heat shock protein, mitochondrial; Hsp10; Chaperonin 10; CPN10; EPF; HSPE1	Human	E. coli
	The HSP10/EPF protein is a cochaperone that plays a role in mitochondrial protein import and assembly. HSP10/EPF Protein, Human (His) is the recombinant human-derived HSP10/EPF protein, expressed by E. coli , with N-His, N-6*His labeled tag. The total length of HSP10/EPF Protein, Human (His) is 102 a.a., with molecular weight of ~13 KDa.

HY-P74878

	HSP27/HSPB1 Protein, Human (His) Heat shock protein beta-1; HspB1; HSP 27; SRP27; HSPB1; HSP28	Human	E. coli
	The HSP27/HSPB1 protein is a small heat shock protein that acts as a molecular chaperone, possibly maintaining denatured proteins in a foldable state. In addition to its chaperone role, it crucially enhances stress resistance and contributes to actin organization. HSP27/HSPB1 Protein, Human (His) is the recombinant human-derived HSP27/HSPB1 protein, expressed by E. coli , with C-His labeled tag. The total length of HSP27/HSPB1 Protein, Human (His) is 205 a.a., with molecular weight of ~28 kDa.

HY-P71537

	TRAP1 Protein, Human (GST) Heat shock protein 75kDa; Heat shock protein 75kDa, mitochondrial; HSP 75; HSP75; HSP90L; mitochondrial; TNF receptor associated protein 1; TNFR-associated protein 1; TRAP-1; Trap1; TRAP1_HUMAN; Tumor necrosis factor type 1 receptor-associated protein	Human	E. coli
	As a chaperone with ATPase activity, TRAP1 protein plays a crucial role in protecting mitochondrial function and polarization, especially downstream of PINK1 and mitochondrial complex I. TRAP1 acts as a negative regulator of mitochondrial respiration, affecting the balance between oxidative phosphorylation and aerobic glycolysis. TRAP1 Protein, Human (GST) is the recombinant human-derived TRAP1 protein, expressed by E. coli , with N-GST labeled tag. The total length of TRAP1 Protein, Human (GST) is 249 a.a., with molecular weight of ~54.5 kDa.

HY-P70945

	HSPB11 Protein, Human (His) Heat shock Protein Beta-11; Hspb11; Placental Protein 25; PP25; HSPB11; C1orf41	Human	E. coli
	The HSPB11 protein is an important component of IFT complex B and is indispensable for sonic eager/SHH signaling. It promotes intraflagellar transport in ciliated tissues such as kidney and testis, mediating the transport of SHH components. HSPB11 Protein, Human (His) is the recombinant human-derived HSPB11 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HSPB11 Protein, Human (His) is 144 a.a., with molecular weight of ~21.0 kDa.

HY-P7872

	Alpha-crystallin A chain/CRYAA Protein, Human (His) rHuAlpha-crystallin A chain/CRYAA, His; Alpha-Crystallin A Chain; Heat shock Protein Beta-4; HspB4; Alpha-Crystallin A Chain; Short Form; CRYAA; CRYA1; HSPB4	Human	E. coli
	Alpha-crystallin A chain/CRYAA Protein, Human (His) is a recombinant Alpha-crystallin A chain protein with a His tag. Alpha-crystallin A chain/CRYAA is a small heat shock protein and molecular chaperone that prevents nonspecific aggregation of denaturing proteins. Several point mutations in the alphaA-crystallin gene cause congenital human cataracts by unknown mechanisms.

HY-P7873

	Alpha-crystallin B chain/CRYAB Protein, Human (His) rHuAlpha-crystallin B chain/CRYAB, His; Alpha-Crystallin B Chain; Alpha(B)-Crystallin; Heat shock Protein Beta-5; HspB5; Renal Carcinoma Antigen NY-REN-27; Rosenthal Fiber Component; CRYAB; CRYA2	Human	E. coli
	Alpha-crystallin B chain/CRYAB Protein, Human (His) expresses in E. coli with a His tag at the N-terminus. CRYAB is an important member of the small heat shock protein family, and plays a protective role in neurological inflammation.

HY-P70933

	HSPB8 Protein, Human (His) Heat shock protein beta-8; HspB8; Alpha-crystallin C chain; E2-induced gene 1 protein; Protein kinase H11; Small stress protein-like protein HSP22; HSPB8; CRYAC; E2IG1; HSP22	Human	E. coli
	The HSPB8 protein exhibits temperature-dependent chaperone activity and functions as a monomer in its molecular form. It interacts with other cellular proteins to form complexes critical for cellular homeostasis. HSPB8 Protein, Human (His) is the recombinant human-derived HSPB8 protein, expressed by E. coli , with C-6*His labeled tag. The total length of HSPB8 Protein, Human (His) is 196 a.a., with molecular weight of ~23.0 kDa.

HY-P701386

	HSPBP1 Protein, Human HSPBP1; Hsp70-binding protein 1; HspBP1; Heat shock protein-binding protein 1; Hsp70-binding protein 2; HspBP2; Hsp70-interacting protein 1; Hsp70-interacting protein 2	Human	E. coli
	HSPBP1 protein regulates HSPA1A chaperone activity by inducing conformational changes in the ATP-binding domain and disrupting ATP binding. This interference inhibits the STUB1-mediated ubiquitination process and blocks chaperone-assisted degradation of immature CFTR. HSPBP1 Protein, Human is the recombinant human-derived HSPBP1 protein, expressed by E. coli , with tag free. The total length of HSPBP1 Protein, Human is 276 a.a., .

HY-P701387

	HSPBP1 Protein, Human (His) HSPBP1; Hsp70-binding protein 1; HspBP1; Heat shock protein-binding protein 1; Hsp70-binding protein 2; HspBP2; Hsp70-interacting protein 1; Hsp70-interacting protein 2	Human	E. coli
	HSPBP1 protein regulates HSPA1A chaperone activity by inducing conformational changes in the ATP-binding domain and disrupting ATP binding. This interference inhibits the STUB1-mediated ubiquitination process and blocks chaperone-assisted degradation of immature CFTR. HSPBP1 Protein, Human (His) is the recombinant human-derived HSPBP1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HSPBP1 Protein, Human (His) is 276 a.a., .

HY-P71298

	Serpin H1 Protein, Human (HEK293, His) Serpin H1; 47 kDa Heat shock Protein; Arsenic-Transactivated Protein 3; AsTP3; Cell Proliferation-Inducing Gene 14 Protein; Collagen-Binding Protein; Colligin; Rheumatoid Arthritis-Related Antigen RA-A47; SERPINH1; CBP1; CBP2; HSP47; SERPINH2	Human	HEK293
	Serpin H1 protein exhibits a specific affinity for collagen, indicating its role as a chaperone in the biosynthetic pathway of collagen. This suggests its potential contribution to collagen synthesis, emphasizing its importance in maintaining tissue integrity and modulating cellular responses related to collagen metabolism. Serpin H1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin H1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin H1 Protein, Human (HEK293, His) is 400 a.a., with molecular weight of ~51.0 kDa.

Cat. No.	Product Name	Chemical Structure

HY-B1455S1

Clindamycin-13C,d3

Clindamycin- ¹³C,d₃ is the ¹³C- and deuterium labeled Clindamycin. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria[1][2][3].

HY-B1455S

Clindamycin-d3 hydrochloride

Clindamycin-d₃ (hydrochloride) is the deuterium labeled Clindamycin. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria[1][2].

Cat. No.	Product Name	Application	Reactivity

HY-P80708

Hsc70 Antibody Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)	WB, IHC-P, IP	Human, Mouse, Rat, Hamster
Hsc70 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 71 kDa, targeting to Hsc70. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat, Hamster.

HY-P83311

HspA2 Antibody (YA3056)

HSPA2; Heat shock 70kD protein 2; HSP70-2; HSP70-3; Heat shock 70 kDa protein 2; Heat shock 70kDa protein 2
WB, IHC-P Human, Mouse, Rat
HY-P83427

HspA4 Antibody (YA3172)

HSPA4; APG2; Heat shock 70 kDa protein 4; HSP70RY; Heat shock 70-related protein APG-2
WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

HY-P83202

HspA12A Antibody (YA2947) FLJ13874 antibody; Heat shock 70 kDa protein 12A antibody; heat shock 70kD protein 12A antibody; heat shock 70kDa protein 12A antibody; HS12A_HUMAN antibody; Hspa12a antibody; KIAA0417 antibody	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

HY-P80714

Hsp90 alpha/beta Antibody HSP90AA1; HSP90A; HSPC1; HSPCA; Heat shock protein HSP 90-alpha; Heat shock 86 kDa; HSP 86; HSP86; Renal carcinoma antigen NY-REN-38; HSP90AB1; HSP90B; HSPC2; HSPCB; Heat shock protein HSP 90-beta; HSP 90; Heat shock 84 kDa; HSP 84; HSP84	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
Hsp90 alpha/beta Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 85 kDa, targeting to Hsp90 alpha/beta. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P83258

HspA14 Antibody (YA3003)

HSPA14; HSP60; HSP70L1; Heat shock 70 kDa protein 14; HSP70-like protein 1; Heat shock protein HSP60
WB, ICC/IF, IP Human, Mouse
HY-P83429

Hsp20 Antibody (YA3174)

HSPB6; HEL55; Hsp20; Heat-shock 20 kDa like-protein p20
WB, IHC-P, FC Human, Mouse, Rat

HY-P80709

Hsp27 Antibody (YA732) HSPB1; HSP27; HSP28; Heat shock protein beta-1; HspB1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27	WB, ICC/IF	Human, Monkey
Hsp27 Antibody (YA732) is a non-conjugated and Mouse origined monoclonal antibody about 23 kDa, targeting to Hsp27 (7E5). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Monkey.

HY-P80823

Phospho-Hsp27 (Ser78) Antibody HSPB1; HSP27; HSP28; Heat shock protein beta-1; HspB1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27	WB, IHC-P, ICC/IF	Human
Phospho-Hsp27 (Ser78) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 23 kDa, targeting to Phospho-Hsp27 (Ser78). It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human.

HY-P80824

Phospho-Hsp27 (Ser82) Antibody HSPB1; HSP27; HSP28; Heat shock protein beta-1; HspB1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27	WB, IHC-P	Human
Phospho-Hsp27 (Ser82) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 23 kDa, targeting to Phospho-Hsp27 (Ser82). It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P81052

HSF1 Antibody (YA896) HSF1; HSTF1; Heat shock factor protein 1; HSF 1; Heat shock transcription factor 1; HSTF 1	WB, IHC-P, ICC/IF, IP, FC	Human
HSF1 Antibody (YA896) is an unconjugated, approximately 57-80 kDa, rabbit-derived, anti-HSF1 (YA896) monoclonal antibody. HSF1 Antibody (YA896) can be used for: WB, IHC-P, ICC/IF, IP, FC expriments in human background without labeling.

HY-P82490

Hsf2 Antibody (YA2235)

HSF2; HSTF2; Heat shock factor protein 2; HSF 2; Heat shock transcription factor 2; HSTF 2
WB, ICC/IF, FC Human

HY-P80710

Hsp40 Antibody DNAJB1; DNAJ1; HDJ1; HSPF1; DnaJ homolog subfamily B member 1; DnaJ protein homolog 1; Heat shock 40 kDa protein 1; HSP40; Heat shock protein 40; Human DnaJ protein 1; hDj-1	WB	Human
Hsp40 Antibody is a non-conjugated and Mouse origined monoclonal antibody about 38 kDa, targeting to Hsp40. It can be used for WB assays with tag free, in the background of Human.

HY-P80822

Phospho-HSF1 (Ser303/Ser307) Antibody HSF1; HSTF1; Heat shock factor protein 1; HSF 1; Heat shock transcription factor 1; HSTF 1	WB, IHC-P	Human
Phospho-HSF1 (Ser303/Ser307) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 57 kDa, targeting to Phospho-HSF1 (Ser303/Ser307). It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P81050

Phospho-HSF1 (Ser326) Antibody(YA894) HSF1; HSTF1; Heat shock factor protein 1; HSF 1; Heat shock transcription factor 1; HSTF 1	WB, IF-Cell, IHC-P, IP, FC	Human
Phospho-HSF1 (Ser326) Antibody(YA894) is an unconjugated, approximately 57 kDa, rabbit-derived, anti-HSF1 (Ser326)(YA894) monoclonal antibody. Phospho-HSF1 (Ser326) Antibody(YA894) can be used for: WB, IF-Cell, IHC-P, IP, FC expriments in human background without labeling.

HY-P83003

DNAJA1 Antibody (YA2748) DNAJA1; DNAJ2; HDJ2; HSJ2; HSPF4; DnaJ homolog subfamily A member 1; DnaJ protein homolog 2; HSDJ; Heat shock 40 kDa protein 4; Heat shock protein J2; HSJ-2; Human DnaJ protein 2; hDj-2	WB, IP, FC	Human, Mouse, Rat

HY-P80696

GRP78 BiP Antibody (YA746) HSPA5; GRP78; 78 kDa glucose-regulated protein; GRP-78; Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP	WB, ICC/IF, IP	Human, Mouse, Rat
GRP78 BiP Antibody (YA746) is a non-conjugated and Mouse origined monoclonal antibody about 72 kDa, targeting to GRP78 BiP (4F11). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P83410

GRP75 Antibody (YA3155) HSPA9; GRP75; HSPA9B; Stress-70 protein; mitochondrial; 75 kDa glucose-regulated protein; GRP-75; Heat shock 70 kDa protein 9; Mortalin; MOT; Peptide-binding protein 74; PBP74	WB	Human, Mouse, Rat

HY-P80711

Hsp60 Antibody (YA730) HSPD1; HSP60; 60 kDa heat shock protein; mitochondrial; 60 kDa chaperonin; Chaperonin 60; CPN60; Heat shock protein 60; HSP-60; Hsp60; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein	WB, ICC/IF, IP	Human, Mouse, Rat
Hsp60 Antibody (YA730) is a non-conjugated and Mouse origined monoclonal antibody about 61 kDa, targeting to Hsp60 (6C8). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P82445

Cpn10 Antibody (YA2190)

HSPE1; 10 kDa heat shock protein; mitochondrial; Hsp10; 10 kDa chaperonin; Chaperonin 10; CPN10; Early-pregnancy factor; EPF
WB, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P82868

Hsp110 Antibody (YA2613)

Antigen NY-CO-25; Heat shock protein 105 kDa; HS105; HSP105; HSP105A; HSP105B; HSP110; HSPH1
WB, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P82278

AHA1 Antibody (YA2023)

AHSA1; C14orf3; HSPC322; Activator of 90 kDa heat shock protein ATPase homolog 1; AHA1; p38
WB, IP Human, Mouse, Rat

HY-P82872

HspB8 Antibody (YA2617) HSPB8; CRYAC; E2IG1; HSP22; PP1629; Heat shock protein beta-8; HspB8; Alpha-crystallin C chain; E2-induced gene 1 protein; Protein kinase H11; Small stress protein-like protein HSP22	WB, IHC-P, ICC/IF	Human, Mouse, Rat

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