sialic

By Targets:	Apoptosis (1) Biochemical Assay Reagents (2) Endogenous Metabolite (9) Influenza Virus (3) Sialyltransferase (2)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (3) Metabolic Disease (8) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112942A

*CMP-Sialic* acid sodium salt** CMP-Neu5Ac sodium salt	Endogenous Metabolite	Metabolic Disease
CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium salt is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .

HY-E70024

*CMP-sialic* acid synthetase (NmCSS)**	Sialyltransferase	Others
CMP-sialic acid synthetase (NmCSS) is an essential enzyme involved in the biosynthesis of carbohydrates and glycoconjugates containing sialic acids. CMP-sialic acid synthetase (NmCSS) activates free Sia, converting it to CMP-Sia, which is the only donor substrate for all sialyltransferases .

HY-P2988A

α2-3,6 Neuraminidase, Bifidobacterium infantis	Others	Metabolic Disease
α2-3,6 Neuraminidase, Bifidobacterium infantis is a highly specific exoglycosidase that catalyzes the hydrolysis of non-reducing terminal α2-3 and α2-6 unbranched sialic acid residues from complex carbohydrates and glycoproteins. α2-3,6 Neuraminidase does not exhibit activity on α2-8 or branched sialic acids .

HY-P2977

N-Acetylneuraminate lyase (CgNal) sialic acid aldolase (CgNal)	Endogenous Metabolite	Others
N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)) is a class I aldolase, is often used in biochemical studies. N-Acetylneuraminate lyase (CgNal) catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac) .

HY-112942

*CMP-Sialic* acid** CMP-Neu5Ac	Endogenous Metabolite	Metabolic Disease
CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .

HY-147168

Biocytin hydrazide

Others Metabolic Disease

Biocytin hydrazide is a selective label for sialic acids, galactose, and other sugars in glycoconjugates using avidin-biotin technology .

Biocytin hydrazide	Others	Metabolic Disease
Biocytin hydrazide is a selective label for sialic acids, galactose, and other sugars in glycoconjugates using avidin-biotin technology .

HY-161160

Ac4ManNDAz	Others	Others
Ac4ManNDAz is a cell-permeable photocross-linking probe. Ac4ManNDAz can effectively compete with endogenous sialic acid for incorporation into cell surface glycoproteins and form cross-links with glycoprotein ligands under UV light irradiation. Ac4ManNDAz can be used to study interactions between glycoproteins .

HY-110288

3FAx-Neu5Ac	Sialyltransferase	Metabolic Disease
3FAx-Neu5Ac (compound 8), a Sialic acid peracetylated analog, is a sialyltransferase inhibitor. 3FAx-Neu5Ac substantially reduces expression of the sialylated ligand sialyl Lewis X on myeloid cells .

HY-I0400

N-Acetylneuraminic acid 2 Publications Verification NANA; Lactaminic acid	Influenza Virus Endogenous Metabolite	Cardiovascular Disease
N-Acetylneuraminic acid is a nine-carbon, sialic acid monosaccharide commonly found in glycoproteins on cell membranes and in glycolipids such as gangliosides in mammalian cells.

HY-128965

N-Glycolylneuraminic acid NeuGc; GcNeu	Influenza Virus Endogenous Metabolite	Inflammation/Immunology
N-Glycolylneuraminic acid is a nonhuman sialic acid molecule synthesized in pigs but not in humans. N-Glycolylneuraminic acid works as a decoy receptor of N-Glycolylneuraminic acid-binding influenza A viruses (IAVs) .

HY-D0871

CHES N-Cyclohexyltaurine	Biochemical Assay Reagents	Others
CHES (N-Cyclohexyltaurine) is a zwitterionic buffer. CHES can bind to hemagglutinin (HA) emulating with sialic acid (SA) and receptor binding site (RBS)-targeting broadly neutralizing antibodies .

HY-P2988B

Neuraminidase, arthrobacter ureafaciens	Others	Infection
Neuraminidase, arthrobacter ureafaciens is an exosialidase which cleaves α-ketosidic linkage between the sialic (N-acetylneuraminic) acid and an adjacent sugar residue. Neuraminidase can facilitate virus release from infected cells .

HY-128965R

N-Glycolylneuraminic acid (Standard) NeuGc (Standard); GcNeu (Standard)	Influenza Virus Endogenous Metabolite	Inflammation/Immunology
N-Glycolylneuraminic acid (Standard) is the analytical standard of N-Glycolylneuraminic acid. This product is intended for research and analytical applications. N-Glycolylneuraminic acid is a nonhuman sialic acid molecule synthesized in pigs but not in humans. N-Glycolylneuraminic acid works as a decoy receptor of N-Glycolylneuraminic acid-binding influenza A viruses (IAVs) .

HY-P2988

Neuraminidase, Microorganism Exo-α-sialidase	Endogenous Metabolite	Infection
Neuraminidase, Microorganism (Exo-α-sialidase) is an exosialidase, is often used in biochemical studies. Neuraminidase cleaves α-ketosidic linkage between the sialic (N-acetylneuraminic) acid and an adjacent sugar residue. Neuraminidase, derived from mucosal pathogens, is a virulence factor that modifies the host's response to infection .

HY-E70062

α-2,3-Sialyltransferase, pasteurella multocida Fh8-PmST3	Endogenous Metabolite	Metabolic Disease
alpha-2,3-Sialyltransferase (PmST3) (EC 2.4.99.4) is a beta-galactoside. alpha-2,3-Sialyltransferase (PmST3) catalyzes the transfer of sialic acid to carbohydrate groups of glycoproteins and glycolipids .

HY-P99371

Lirentelimab AK002; Anti-Siglec-8 Reference Antibody (lirentelimab)	Apoptosis	Inflammation/Immunology
Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis .

HY-E70063

alpha-2,3-Sialyltransferase (Phα2,3SiaT)	Endogenous Metabolite	Metabolic Disease
alpha-2,3-Sialyltransferase (Phα2,3SiaT) is a beta-galactoside. alpha-2,3-Sialyltransferase (Phα2,3SiaT) catalyzes the transfer of sialic acid to carbohydrate groups of glycoproteins and glycolipids .

HY-E70132

Endo-β-N-acetylglucosaminidase D Endo D	Others	Metabolic Disease
Endo-β-N-acetylglucosaminidase D (Endo D), isolated from Streptococcus pneumoniae. Endo-β-N-acetylglucosaminidase D hydrolyzes Fc N-glycan of intact IgG antibodies after sequential removal of the sialic acid, galactose, and internal GlcNAc residues in the N-glycan. Endo-β-N-acetylglucosaminidase D possesses transglycosylation activity with sugar oxazoline as the donor substrate .

HY-E70097

Sialidase (α2-3-6-8-9)	Others	Others
Sialidase (α2-3-6-8-9) is a broadly specific sialidase that cuts linear and branched non-reducing terminal sialic acid residues from glycoproteins, glycopeptides, and oligosaccharides. Sialidase (α2-3-6-8-9) can be used for in vitro and in vivo polysaccharide analysis and characterization as well as complete glycoprotein remodeling .

HY-145533

3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid KDN	Others	Others
3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) is a sialic acid. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid protects the oligo/(poly)sialyl chains from exosialidases at nonreducing terminal, and plays a role in egg activation of salmonid fish . 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid is abundant in fetal cord red blood cells and malignant human ovarian cancer cells .

HY-W127461

Ganglioside GM2, Asialo Gangliotriosylceramide	Biochemical Assay Reagents	Others
Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.

Cat. No.	Product Name	Type

HY-D0871

CHES N-Cyclohexyltaurine	Dyes
CHES (N-Cyclohexyltaurine) is a zwitterionic buffer. CHES can bind to hemagglutinin (HA) emulating with sialic acid (SA) and receptor binding site (RBS)-targeting broadly neutralizing antibodies .

Cat. No.	Product Name	Type

HY-P2977

N-Acetylneuraminate lyase (CgNal) sialic acid aldolase (CgNal)	Biochemical Assay Reagents
N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)) is a class I aldolase, is often used in biochemical studies. N-Acetylneuraminate lyase (CgNal) catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac) .

HY-E70073

Ganglioside sialidase (AuSialidase M2) Sialidase isoenzyme M2; AuSialidase M2	Biochemical Assay Reagents
Ganglioside sialidase (AuSialidase M2) from Arthrobacter ureafaciens. Ganglioside sialidase is a highly specific N-acetylneuraminidase. Ganglioside sialidase can hydrolyze the internal sialic acid of GM1 under optimal condition with sodium cholate .

HY-E70148

ST6 Gal Sialyltransferase 1 EC:2.4.3.1; ST6GAL1	Enzyme Substrates
ST6 Gal Sialyltransferase 1 (EC:2.4.3.1, ST6GAL1) catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates .

HY-E70146

ST3 β-Gal α-2,3-Sialyltransferase 2 EC:2.4.3.4; ST3GAL2	Enzyme Substrates
ST3 beta-Gal alpha-2,3-Sialyltransferase 2 (EC:2.4.3.4, ST3GAL2) catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates .

HY-E70152

ST6 Sialyltransferase 4 EC:2.4.3.7; ST6GALNAC4; SIAT3-C	Enzyme Substrates
ST6 Sialyltransferase 4 (EC:2.4.3.7; ST6GALNAC4; SIAT3-C; SIAT3C; SIAT7-D; SIAT7D) catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. ST6 Sialyltransferase 4 promotes hepatocellular carcinogenesis by inducing abnormal glycosylation. .

HY-E70151

ST6 Sialyltransferase 2

EC:2.4.3.3; ST6GALNAC2
Enzyme Substrates

ST6 Sialyltransferase 2 (EC:2.4.3.3, ST6GALNAC2) add sialic acids to the nonreducing ends of glycoconjugates .

ST6 Sialyltransferase 2 EC:2.4.3.3; ST6GALNAC2	Enzyme Substrates
ST6 Sialyltransferase 2 (EC:2.4.3.3, ST6GALNAC2) add sialic acids to the nonreducing ends of glycoconjugates .

HY-D0871

CHES N-Cyclohexyltaurine	Dyes
CHES (N-Cyclohexyltaurine) is a zwitterionic buffer. CHES can bind to hemagglutinin (HA) emulating with sialic acid (SA) and receptor binding site (RBS)-targeting broadly neutralizing antibodies .

HY-E70149

ST6 Gal Sialyltransferase 2 EC:2.4.3.1; ST6GAL2	Enzyme Substrates
ST6 Gal Sialyltransferase 2 (EC:2.4.3.1, ST6GAL2) catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. ST6 Gal Sialyltransferase 2 plays an important role in schizophrenic research .

HY-E70039

alpha-2-3,6,8-Sialidosidase (SpNanA)	Biochemical Assay Reagents
alpha-2-3,6,8-Sialidosidase (SpNanA) catalyses hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates .

HY-E70063

alpha-2,3-Sialyltransferase (Phα2,3SiaT)	Biochemical Assay Reagents
alpha-2,3-Sialyltransferase (Phα2,3SiaT) is a beta-galactoside. alpha-2,3-Sialyltransferase (Phα2,3SiaT) catalyzes the transfer of sialic acid to carbohydrate groups of glycoproteins and glycolipids .

HY-E70150

ST6 Sialyltransferase 1 EC:2.4.3.3; Alpha-N-Acetylgalactosaminide alpha-2,6-sialyltransferase 1	Enzyme Substrates
ST6 Sialyltransferase 1 (EC:2.4.3.3, ST6GALNAC1, SIAT7A, Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1)? transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. ST6 Sialyltransferase 1 plays an important role in cancer .

HY-E70147

ST3 β-Gal α-2,3-Sialyltransferase 6 EC:2.4.99.; ST3GAL6; Type 2 lactosamine α-2,3-sialyltransferase	Enzyme Substrates
ST3 beta-Gal alpha-2,3-Sialyltransferase 6 (EC:2.4.99., ST3GAL6; SIAT10, Type 2 lactosamine alpha-2,3-sialyltransferase) transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. ST3 beta-Gal alpha-2,3-Sialyltransferase 6 play an important role in cancer .

ST3 β-Gal α-2,3-Sialyltransferase 6

EC:2.4.99.; ST3GAL6; Type 2 lactosamine α-2,3-sialyltransferase

Enzyme Substrates

ST3 beta-Gal alpha-2,3-Sialyltransferase 6 (EC:2.4.99., ST3GAL6; SIAT10, Type 2 lactosamine alpha-2,3-sialyltransferase) transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. ST3 beta-Gal alpha-2,3-Sialyltransferase 6 play an important role in cancer .

HY-W127461

Ganglioside GM2, Asialo Gangliotriosylceramide	Biochemical Assay Reagents
Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.

Ganglioside GM2, Asialo

Gangliotriosylceramide

Biochemical Assay Reagents

Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.

Cat. No.	Product Name	Target	Research Area

HY-P2977

N-Acetylneuraminate lyase (CgNal) sialic acid aldolase (CgNal)	Endogenous Metabolite	Others
N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)) is a class I aldolase, is often used in biochemical studies. N-Acetylneuraminate lyase (CgNal) catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac) .

Cat. No.	Product Name	Target	Research Area

HY-P99371

Lirentelimab AK002; Anti-Siglec-8 Reference Antibody (lirentelimab)	Apoptosis	Inflammation/Immunology
Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-112942A

*CMP-Sialic* acid sodium salt** CMP-Neu5Ac sodium salt	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium salt is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .

HY-I0400

N-Acetylneuraminic acid 2 Publications Verification NANA; Lactaminic acid	Cardiovascular Disease Structural Classification Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Monosaccharides	Influenza Virus Endogenous Metabolite
N-Acetylneuraminic acid is a nine-carbon, sialic acid monosaccharide commonly found in glycoproteins on cell membranes and in glycolipids such as gangliosides in mammalian cells.

HY-128965

N-Glycolylneuraminic acid NeuGc; GcNeu	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Influenza Virus Endogenous Metabolite
N-Glycolylneuraminic acid is a nonhuman sialic acid molecule synthesized in pigs but not in humans. N-Glycolylneuraminic acid works as a decoy receptor of N-Glycolylneuraminic acid-binding influenza A viruses (IAVs) .

HY-112942

*CMP-Sialic* acid** CMP-Neu5Ac	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .

HY-128965R

N-Glycolylneuraminic acid (Standard) NeuGc (Standard); GcNeu (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Influenza Virus Endogenous Metabolite
N-Glycolylneuraminic acid (Standard) is the analytical standard of N-Glycolylneuraminic acid. This product is intended for research and analytical applications. N-Glycolylneuraminic acid is a nonhuman sialic acid molecule synthesized in pigs but not in humans. N-Glycolylneuraminic acid works as a decoy receptor of N-Glycolylneuraminic acid-binding influenza A viruses (IAVs) .

Species:	Human (18) Mouse (5) Cynomolgus (2)
Tag:	His (16) Avi (2) Myc (1) MBP (1) Fc (11) Flag (2)
Source:	HEK293 (22) Sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71314

	Siglec-E Protein, Mouse (HEK293, Fc) SiglecE; Siglec-E; sialic Acid Binding Ig-like Lectin E	Mouse	HEK293
	Siglec-E Protein is a mouse orthologue of human Siglec-9 and functions as a key immunosuppressive checkpoint molecule. Siglec-E interacts with CD36 to inhibits downstream VAV signaling involved in modified LDL uptake, thereby delaying atherosclerosis. The endogenous inducible Siglec-E plays crucial anti-inflammatory and neuroprotective roles following ischemic stroke. Siglec-E Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Siglec-E protein, expressed by HEK293, with C-hFc labeled tag. The total length of Siglec-E Protein, Mouse (HEK293, Fc) is 336 a.a., with molecular weight of ~95 kDa.

HY-P71309

	SIAE Protein, Human (HEK293, His) Sialate O-Acetylesterase; H-Lse; sialic Acid-Specific 9-O-Acetylesterase; SIAE; YSG2	Human	HEK293
	SIAE proteins play a key role in cellular processes by catalyzing the removal of the O-acetyl ester group specifically from the 9-position of the parent sialic acid N-acetylneuraminic acid. Through this enzymatic activity, SIAE helps regulate sialic acid modifications, affecting various biological functions associated with cell surface glycoconjugates. SIAE Protein, Human (HEK293, His) is the recombinant human-derived SIAE protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SIAE Protein, Human (HEK293, His) is 500 a.a., with molecular weight of 64-77 kDa.

HY-P74548

	SIAE Protein, Human (sf9, His) Sialate O-Acetylesterase; H-Lse; sialic Acid-Specific 9-O-Acetylesterase; SIAE; YSG2	Human	Sf9 insect cells
	SIAE proteins play a key role in cellular processes by catalyzing the removal of the O-acetyl ester group specifically from the 9-position of the parent sialic acid N-acetylneuraminic acid. Through this enzymatic activity, SIAE helps regulate sialic acid modifications, affecting various biological functions associated with cell surface glycoconjugates. SIAE Protein, Human (sf9, His) is the recombinant human-derived SIAE protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of SIAE Protein, Human (sf9, His) is 523 a.a., with molecular weight of ~61 kDa.

HY-P70959

	NANS Protein, Human (His) sialic Acid Synthase; N-Acetylneuraminate Synthase; N-Acetylneuraminate-9-Phosphate Synthase; N-Acetylneuraminic Acid Phosphate Synthase; N-Acetylneuraminic Acid Synthase; NANS; SAS	Human	E. coli
	NANS Protein is an enzyme that functions in the biosynthetic pathways of sialic acids. NANS protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively. NANS Protein, Human (His) is the recombinant human-derived NANS protein, expressed by E. coli , with N-6*His labeled tag. The total length of NANS Protein, Human (His) is 359 a.a., with molecular weight of ~42.0 kDa.

HY-P70960

	Siglec-5 Protein, Cynomolgus (HEK293, His) sialic acid-binding Ig-like lectin 5; Siglec-5	Cynomolgus	HEK293
	Siglec-5 Protein is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. Siglec-5 is a member of the CD33-related subset of Siglecs and is expressed on myeloid cells of the hemopoietic system. Siglec-5 inhibits the response of innate immune cells, such as monocytes and neutrophils against pathogens. Siglec-5 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Siglec-5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-5 Protein, Cynomolgus (HEK293, His) is 419 a.a., with molecular weight of ~90.0 kDa.

HY-P72476

	Siglec-10 Protein, Human (HEK293, Fc) sialic acid-binding Ig-like lectin 10; Siglec-10; SIGLEC10; SLG2	Human	HEK293
	Siglec-10 protein is thought to be a putative adhesion molecule that mediates sialic acid-dependent cell binding, preferentially selecting α-2,3- or α-2,6-linked sialic acid. Its sialic acid recognition site may be masked by cis interactions. Siglec-10 Protein, Human (HEK293, Fc) is the recombinant human-derived Siglec-10 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Siglec-10 Protein, Human (HEK293, Fc) is 530 a.a., with molecular weight of 110-130 kDa.

HY-P76642

	Siglec-10 Protein, Human (HEK293, His) sialic acid-binding Ig-like lectin 10; Siglec-10; SIGLEC10; SLG2	Human	HEK293
	Siglec-10 protein is thought to be a putative adhesion molecule that mediates sialic acid-dependent cell binding, preferentially selecting α-2,3- or α-2,6-linked sialic acid. Its sialic acid recognition site may be masked by cis interactions. Siglec-10 Protein, Human (HEK293, His) is the recombinant human-derived Siglec-10 protein, expressed by HEK293 , with C-His labeled tag. The total length of Siglec-10 Protein, Human (HEK293, His) is 534 a.a., with molecular weight of ~59.5 kDa.

HY-P71311

	Siglec-7 Protein, Human (HEK293, His) sialic acid-binding Ig-like lectin 7; AIRM-1; D-siglec; CD328; SIGLEC7	Human	HEK293
	Siglec-7 protein is a putative adhesion molecule that mediates sialic acid-dependent cell binding with preference for α-2,3- and α-2,6-linked sialic acids. It interacts with disialoganglioside and may be masked by cis interactions. Siglec-7 Protein, Human (HEK293, His) is the recombinant human-derived Siglec-7 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-7 Protein, Human (HEK293, His) is 335 a.a., with molecular weight of 50-70 kDa.

HY-P70739

	Siglec-9 Protein, Human (HEK293, His) sialic acid-binding Ig-like lectin 9; Siglec-9; CDw329; Protein FOAP-9; SIGLEC9	Human	HEK293
	Siglec-9 Protein is a member of the Siglec cell surface immunoglobulin family. Siglec-9 is highly expressed on human neutrophils and monocytes and low on natural killer cells, and sub-populations of T and B lymphocytes. Siglec-9 induces human neutrophil apoptosis and autophagy-like cell death and also inhibits tumor activity. Siglec-9 Protein, Human (HEK293, His) is the recombinant human-derived Siglec-9 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-9 Protein, Human (HEK293, His) is 331 a.a., with molecular weight of 55-90 kDa.

HY-P72470

	Siglec-F Protein, Mouse (HEK293, His) SAF2; sialic acid binding Ig like lectin 8; SIGLEC-8; SIGLEC8L; SiglecF; Siglec-F	Mouse	HEK293
	Siglec-F Protein, a putative adhesion molecule, crucially mediates sialic-acid dependent binding to cells with a preferential affinity for alpha-2,3-linked sialic acid. Notably, its sialic acid recognition site may be concealed through cis interactions with sialic acids on the same cell surface. Siglec-F Protein, Mouse (HEK293, His) is the recombinant mouse-derived Siglec-F protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-F Protein, Mouse (HEK293, His) is 420 a.a., with molecular weight of 55-70 kDa.

HY-P70448

	Siglec-10 Protein, Mouse (HEK293, Fc) SIGLEC10; SiglecG; Siglec-G; MGC126774; PRO940; Siglec10; SLG2; sialic acid-binding Ig-like lectin 10; Siglec-10; siglec-like gene 2; Siglec-like protein 2; SLG2sialic acid binding Ig-like lectin 10 Ig-like lectin 7	Mouse	HEK293
	Siglec-10 protein is an adhesion molecule that mediates sialic acid-dependent cell binding, preferentially selecting α-2,3- or α-2,6-linked sialic acid. Its sialic acid recognition site may be masked through cis interactions. Siglec-10 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Siglec-10 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Siglec-10 Protein, Mouse (HEK293, Fc) is 525 a.a., with molecular weight of 110-135 kDa.

HY-P72021

	Siglec-3/CD33 Protein, Human (HEK293, Fc-Myc) sialic acid-binding Ig-like lectin 3 Siglec-3; gp67; CD33; SIGLEC3	Human	HEK293
	Siglec-3/CD33 protein is a sialic acid-binding lectin that mediates cell-cell interactions and maintains immune cell quiescence. It prefers α-2,3- and α-2,6-linked glycans with sialic acid. Siglec-3/CD33 Protein, Human (HEK293, Fc-Myc) is the recombinant human-derived Siglec-3/CD33 protein, expressed by HEK293 , with C-Myc, C-Fc labeled tag. The total length of Siglec-3/CD33 Protein, Human (HEK293, Fc-Myc) is 242 a.a., with molecular weight of ~92 kDa.

HY-P70738

	Siglec-15 Protein, Human (HEK293, mFc) sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3	Human	HEK293
	The Siglec-15 protein plays a critical role in cellular interactions, selectively binding to sialylated glycoproteins with affinity for sialic acid residues. Binding to TYROBP and HCST suggests involvement in complex signaling pathways. Siglec-15 Protein, Human (HEK293, mFc) is the recombinant human-derived Siglec-15 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of Siglec-15 Protein, Human (HEK293, mFc) is 244 a.a., with molecular weight of 50-70 kDa.

HY-P70742

	Siglec-15 Protein, Human (HEK293, Fc) sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3	Human	HEK293
	The Siglec-15 protein plays a critical role in cellular interactions, selectively binding to sialylated glycoproteins with affinity for sialic acid residues. Binding to TYROBP and HCST suggests involvement in complex signaling pathways. Siglec-15 Protein, Human (HEK293, Fc) is the recombinant human-derived Siglec-15 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Siglec-15 Protein, Human (HEK293, Fc) is 244 a.a., with molecular weight of ~50-80 kDa.

HY-P70743

	Siglec-15 Protein, Cynomolgus (HEK293, His) sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3	Cynomolgus	HEK293
	Siglec-15 Protein, a Siglec family member and type-1 transmembrane protein, is constitutively expressed in osteoclasts, macrophages and dendritic cells. Siglec-15 plays a pivotal role in the development and differentiation of osteoclastogenesis, inhibiting antigen-specific T cell responses in vitro and in vivo. Siglec-15 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Siglec-15 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-15 Protein, Cynomolgus (HEK293, His) is 244 a.a., with molecular weight of 30-40 kDa.

HY-P70744

	Siglec-15 Protein, Mouse (HEK293, His) sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3	Mouse	HEK293
	Siglec-15 Protein, a Siglec family member and type-1 transmembrane protein, is constitutively expressed in osteoclasts, macrophages and dendritic cells. Siglec-15 plays a pivotal role in the development and differentiation of osteoclastogenesis, inhibiting antigen-specific T cell responses in vitro and in vivo. Siglec-15 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Siglec-15 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-15 Protein, Mouse (HEK293, His) is 239 a.a., with molecular weight of 30-40 kDa.

HY-P72475

	Siglec-15 Protein, Human (HEK293, His) sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3	Human	HEK293
	The Siglec-15 protein plays a critical role in cellular interactions, selectively binding to sialylated glycoproteins with affinity for sialic acid residues. Binding to TYROBP and HCST suggests involvement in complex signaling pathways. Siglec-15 Protein, Human (HEK293, His) is the recombinant human-derived Siglec-15 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-15 Protein, Human (HEK293, His) is 244 a.a., with molecular weight of 30-40 kDa.

HY-P70767

	Siglec-15 Protein, Human (Biotinylated, HEK293, Fc-Avi) sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3	Human	HEK293
	The Siglec-15 protein plays a critical role in cellular interactions, selectively binding to sialylated glycoproteins with affinity for sialic acid residues. Binding to TYROBP and HCST suggests involvement in complex signaling pathways. Siglec-15 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived Siglec-15 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of Siglec-15 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 244 a.a., with molecular weight of 58-75 kDa.

HY-P72411

	Siglec-10 Protein, Human (Biotinylated, HEK293, Fc-Avi) MGC126774; PRO940; Siglec10; SLG2; sialic acid-binding Ig-like lectin 10; siglec-like gene 2	Human	HEK293
	Siglec-10 Protein, identified as a putative adhesion molecule, mediates sialic-acid dependent cellular binding, preferring alpha-2,3- or alpha-2,6-linked sialic acid. Its sialic acid recognition site may undergo masking through cis interactions. In immune responses, Siglec-10 acts as an inhibitory receptor, inducing ligand-induced tyrosine phosphorylation, recruiting SH2 domain-containing phosphatases, and negatively regulating B-cell antigen receptor signaling via PTPN6/SHP-1. In collaboration with CD24, it selectively suppresses the immune response to DAMPs, regulates NK cell response, controls autoimmunity, and inhibits cross-presentation during adaptive immune responses by CD8-alpha(+) dendritic cells. Siglec-10 interacts with proteins including PTPN6/SHP-1, NCF1, CD24, HMGB1, RIGI, CBL, and PTPN11. Siglec-10 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived Siglec-10 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of Siglec-10 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 530 a.a., with molecular weight of 100-130 kDa.

HY-P72472

	Siglec-3/CD33 Protein, Human (HEK293, Fc-His) Myeloid Cell Surface Antigen CD33; sialic Acid-Binding Ig-Like Lectin 3; Siglec-3; gp67; CD33; SIGLEC3	Human	HEK293
	Siglec-3/CD33, a sialic-acid-binding lectin, crucially mediates cell-cell interactions and immune cell quiescence. Preferring sialic acid on specific mucins, it forms homodimers, interacting with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation. CD33 also engages C1QA through its C-terminus, activating CD33 inhibitory motifs. Siglec-3/CD33 Protein, Human (HEK293, Fc-His) is the recombinant human-derived Siglec-3/CD33 protein, expressed by HEK293 , with C-hFc, C-6*His labeled tag. The total length of Siglec-3/CD33 Protein, Human (HEK293, Fc-His) is 242 a.a., with molecular weight of ~80 kDa.

HY-P72473

	Siglec-3/CD33 Protein, Mouse (G236R, HEK293, His) Myeloid Cell Surface Antigen CD33; sialic Acid-Binding Ig-Like Lectin 3; Siglec-3; gp67; CD33; SIGLEC3	Mouse	HEK293
	Siglec-3/CD33, a sialic-acid-binding lectin, crucially mediates cell-cell interactions and immune cell quiescence. Preferring sialic acid on specific mucins, it forms homodimers, interacting with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation. CD33 also engages C1QA through its C-terminus, activating CD33 inhibitory motifs. Siglec-3/CD33 Protein, Mouse (G236R, HEK293, His) is the recombinant mouse-derived Siglec-3/CD33 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-3/CD33 Protein, Mouse (G236R, HEK293, His) is 223 a.a., with molecular weight of 30-45 kDa.

HY-P72471

	Siglec-5 Protein, Human (HEK293, Fc) sialic acid-binding Ig-like lectin 5; Siglec-5; CD33 antigen-like 2; Obesity-binding protein 2; OB-BP2; CD170	Human	HEK293
	Siglec-5 Protein, a putative adhesion molecule, participates in sialic-acid dependent cellular binding, showing equal affinity for alpha-2,3-linked and alpha-2,6-linked sialic acid. Its sialic acid recognition site may be masked through cis interactions with sialic acids on the same cell surface. Siglec-5 Protein, Human (HEK293, Fc) is the recombinant human-derived Siglec-5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Siglec-5 Protein, Human (HEK293, Fc) is 418 a.a., with molecular weight of 90-110 kDa.

HY-P71023

	Siglec-5 Protein, Human (HEK293, His-Flag-Fc) sialic acid-binding Ig-like lectin 5; Siglec-5; CD33 antigen-like 2; Obesity-binding protein 2; OB-BP2; CD170	Human	HEK293
	Siglec-5 Protein, a putative adhesion molecule, participates in sialic-acid dependent cellular binding, showing equal affinity for alpha-2,3-linked and alpha-2,6-linked sialic acid. Its sialic acid recognition site may be masked through cis interactions with sialic acids on the same cell surface. Siglec-5 Protein, Human (HEK293, His-Flag-Fc) is the recombinant human-derived Siglec-5 protein, expressed by HEK293 , with C-hFc, C-Flag, C-6*His labeled tag. The total length of Siglec-5 Protein, Human (HEK293, His-Flag-Fc) is 418 a.a., with molecular weight of 90-110 kDa.

HY-P70559

	Siglec-2/CD22 Protein, Human (668a.a, HEK293, His) B-cell receptor CD22; BL-CAM; B-lymphocyte cell adhesion molecule; CD22 antigenMGC130020; CD22 molecule; CD22; sialic acid binding Ig-like lectin 2; Siglec-2; SIGLEC2FLJ22814; T-cell surface antigen Leu-14	Human	HEK293
	The Siglec-2/CD22 protein mediates B cell interactions and may direct B cell localization within lymphoid tissues. It recognizes sialylated glycoproteins, especially α-2,6-linked sialic acid, and participates in cis-interactions at the cell surface. Siglec-2/CD22 Protein, Human (668a.a, HEK293, His) is the recombinant human-derived Siglec-2/CD22 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-2/CD22 Protein, Human (668a.a, HEK293, His) is 668 a.a., with molecular weight of 100-140 kDa.

HY-P702008

	SLC35A1 Protein, Human (Sf9, His, MBP, FLAG) SLC35A1; CMP-sialic acid transporter; CMP-SA-Tr; CMP-Sia-Tr; Solute carrier family 35 member A1	Human	Sf9 insect cells
	SLC35A1 is a key player in intracellular transport, acting as a transporter to transport CMP-sialic acid from the cytoplasm to the Golgi apparatus. As an antiporter, it exchanges CMP-sialic acid for CMP, maintaining cellular homeostasis. SLC35A1 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC35A1 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC35A1 Protein, Human (Sf9, His, MBP, FLAG) is 336 a.a., .

Cat. No.	Product Name	Application	Reactivity

HY-P81515

Sialoadhesin/CD169 Antibody (YA1260)

SIGLEC1; SN; Sialoadhesin; sialic acid-binding Ig-like lectin 1 (Siglec-1); CD169
IHC-P Human

HY-P81522

CD22 Antibody (YA1267) CD22; SIGLEC2; B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD antigen CD22	IHC-P	Human


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