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Results for "

skin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Akt (2) Amino Acid Derivatives (2) AMPK (1) Androgen Receptor (3) Angiotensin Receptor (2) Antibiotic (45) Apoptosis (24) Aryl Hydrocarbon Receptor (3) Aurora Kinase (1) Autophagy (8) Bacterial (91) Beta-lactamase (3) Biochemical Assay Reagents (16) Bombesin Receptor (1) c-Kit (1) Cannabinoid Receptor (3) Casein Kinase (1) Caspase (3) CDK (1) CFTR (1) COX (6) CRFR (2) Cytochrome P450 (2) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (5) Drug Metabolite (2) EBV (1) Elastase (1) Endogenous Metabolite (23) ERK (1) Estrogen Receptor/ERR (6) Eukaryotic Initiation Factor (eIF) (1) FAK (1) Ferroptosis (5) Filovirus (2) FKBP (1) Fluorescent Dye (2) Free Fatty Acid Receptor (1) Fungal (29) Glucocorticoid Receptor (9) Glucosidase (1) GSK-3 (1) HBV (1) HCV (1) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (9) HIV (1) HSP (3) HSV (1) Imidazoline Receptor (2) Interleukin Related (4) IRAK (1) Isotope-Labeled Compounds (10) JAK (8) JNK (1) Keap1-Nrf2 (1) Liposome (1) Lipoxygenase (3) LRRK2 (1) MAP3K (1) Mas-related G-protein-coupled Receptor (MRGPR) (6) MDM-2/p53 (2) MEK (2) Melanocortin Receptor (7) Mitochondrial Metabolism (1) Mitophagy (2) MMP (3) Monoamine Oxidase (4) Necroptosis (1) Neurokinin Receptor (1) NF-κB (4) NO Synthase (1) Opioid Receptor (5) Organoid (1) p38 MAPK (2) Parasite (8) PARP (1) PD-1/PD-L1 (1) Penicillin-binding protein (PBP) (4) PGE synthase (1) Phosphatase (2) Phosphodiesterase (PDE) (2) PI3K (4) PKC (3) Prostaglandin Receptor (1) RAR/RXR (4) Ras (2) Reactive Oxygen Species (4) ROCK (1) ROR (3) SHP2 (1) Sirtuin (1) Smo (1) Sodium Channel (2) SphK (1) Src (1) Stearoyl-CoA Desaturase (SCD) (2) Syk (1) TGF-beta/Smad (2) Thyroid Hormone Receptor (1) TOPK (2) TRP Channel (3) Tyrosinase (15) VEGFR (2) Wnt (2) YAP (1) β-catenin (1)
By Research Areas:	Cancer (80) Cardiovascular Disease (13) Endocrinology (21) Infection (127) Inflammation/Immunology (130) Metabolic Disease (28) Neurological Disease (26)
Click Chemistry:	Alkynes (2)

382

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

117

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Sericoside	Others	Inflammation/Immunology
Sericoside is a triterpenoid with anti-inflammatory activity, can be isolated form Terminalia. Sericoside has a strong lipolytic activity. Sericoside can also reduce skin wrinkles and ameliorating skin texture .

Diethyl fumarate	Others	Inflammation/Immunology
Diethyl fumarate is a decomposition product of Malathion (an insecticide). Diethyl fumarate is a reputed skin irritant. Diethyl fumarate can causes non-immunologic contact urticaria on skin .

Myristyl nicotinate Tetradecyl nicotinate	Others	Cancer
Myristyl nicotinate (Tetradecyl nicotinate) is an ester proagent and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier .

Diflucortolone valerate	Fungal Bacterial	Infection Inflammation/Immunology
Diflucortolone valerate is a powerful corticosteroid used topically for the research of various skin diseases .

Decamethylcyclopentasiloxane	Others	Others
Decamethylcyclopentasiloxane (D5), an organosilicon compound that is used as a skin emollient in cosmetics and personal products .

1-Deoxy-Cer	Others	Others
1-Deoxy-Cer is a Ceramide which is essential component of the skin permeability barrier.

α-Arbutin 4-Hydroxyphenyl α-D-glucopyranoside	Tyrosinase	Metabolic Disease
α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is emerging as popular and effective skin whiteners, acting as tyrosinase inhibitor .

Monobenzone	Others	Inflammation/Immunology
Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and active human vitiligo and exhibits good potential for vitiligo research .

Idrevloride P-1037	Sodium Channel	Others
Idrevloride, an epithelial sodium channel (ENaC) inhibitor (WO2016133967), can be used for the research of skin disorders .

Graveoline Rutamine	Apoptosis Autophagy Fungal	Infection Cancer
Graveoline (Rutamine) is an anti-cancer agent that can trigger apoptosis and autophagy in skin melanoma cells. Graveoline also exhibits antifungal activity .

Elubiol Dichlorophenyl imidazoldioxolan	Others	Others
Elubiol (Dichlorophenyl imidazoldioxolan) has moderate sebum-inhibiting activity and can be used in the treatment of oily skin or dandruff .

Abacavir hydroxyacetate	Others	Inflammation/Immunology
Abacavir hydroxyacetate is an orally active inhibitor of IL-20 and PRINS. Abacavir hydroxyacetate reduces proliferation rate of skin in psoriasis as an immune modulator. Abacavir hydroxyacetate can be used for the research of inflammatory skin problems .

Tetrapeptide-30	Tyrosinase	Inflammation/Immunology
Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation .

Esculentin 1A	Bacterial	Infection
Esculentin 1A is a frog skin-derived antimicrobial peptide (AMP) with potent in vitro anti-Pseudomonas activity .

GSK2646264	Syk Src LRRK2 GSK-3 JAK VEGFR Aurora Kinase	Inflammation/Immunology
GSK2646264 (Compound 44) is a potent and selective spleen tyrosine kinase (SYK) inhibitor with a pIC₅₀ of 7.1. GSK2646264 also inhibits other kinases with pIC₅₀ values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 against LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B and Aurora A, respectively. GSK2646264 is penetrable into the epidermis and dermis of the skin .

Telavancin TD-6424	Antibiotic Bacterial	Infection
Telavancin (TD-6424) is a semisynthetic lipoglycopeptide vancomycin-derivative, is a novel antimicrobial agent developed by Theravance for overcoming resistant Gram-positive bacterial infections, specifically methicillin-resistant Staphylococcus aureus (MRSA). Telavancin disrupts cell membrane integrity, can be used for research of complicated skin and skin structure infections (cSSSIs) caused by Gram-positive bacteria .

Menthyl acetate L-Menthyl acetate; (-)-Menthyl acetate	Others	Others
Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation .

Oligopeptide-20	Bacterial	Others
Oligopeptide-20 is a bioactive peptide with skin repair effect and has been reported used as a cosmetic ingredient .

Anti-inflammatory agent 32	Others	Inflammation/Immunology
Anti-inflammatory agent 32 (compound C3) has anti-oxidative and anti-inflammatory activity. Anti-inflammatory agent 32 can be used for skin care products research and development .

Sapienic acid	Bacterial	Infection
Sapienic acid is a fatty acid commonly found on the skin and in mucosa. Sapienic acid has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid is active against *Streptococcus sanguinis, Streptococcus mitis* and *Fusobacterium nucleatum* with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively .

JAK-IN-18	JAK	Inflammation/Immunology
JAK-IN-18 is a potent inhibitor of JAK. JAK-IN-18 is useful for the research of multiple diseases, particularly ocular, skin, and respiratory diseases (extracted from patent WO2018204238A1, compound 1) .

MrgprX2 antagonist-5	Mas-related G-protein-coupled Receptor (MRGPR)	Inflammation/Immunology
MrgprX2 antagonist-5 is an MrgprX2 antagonist extracted from patent WO2020223255A1, example 16. MrgprX2 antagonist-5 can be used for the research of inflammatory disorders of the skin .

JAK-IN-17	JAK	Inflammation/Immunology
JAK-IN-17 is a potent inhibitor of JAK. JAK-IN-17 is useful for the research of multiple diseases, particularly ocular, skin, and respiratory diseases (extracted from patent WO2021185305A1, compound 9-1) .

Ceftaroline fosamil hydrate TAK-599 hydrate; PPI0903 hydrate	Antibiotic Bacterial	Infection
Ceftaroline fosamil hydrate is a potent cephalosporin antibiotic. Ceftaroline fosamil hydrateshows broad-spectrum activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Streptococcus pneumoniae, and common Gram-negative organisms. Ceftaroline fosamil hydrate has anti-infective activity, and can be used for the research of complicated skin and skin structure infections (cSSSIs) and community-acquired bacterial pneumonia (CABP) .

MrgprX2 antagonist-1 1 Publications Verification	Mas-related G-protein-coupled Receptor (MRGPR)	Inflammation/Immunology
MrgprX2 antagonist-1 is an MrgprX2 antagonist extracted from patent WO2021092264A1, example E23. MrgprX2 antagonist-1 can be used for the research of inflammatory disorders of the skin .

MrgprX2 antagonist-2	Mas-related G-protein-coupled Receptor (MRGPR)	Inflammation/Immunology
MrgprX2 antagonist-2 is an MrgprX2 antagonist extracted from patent WO2021092262A1, example E163. MrgprX2 antagonist-2 can be used for the research of inflammatory disorders of the skin .

MrgprX2 antagonist-3	Mas-related G-protein-coupled Receptor (MRGPR)	Inflammation/Immunology
MrgprX2 antagonist-3 is an MrgprX2 antagonist extracted from patent WO2021092240A1, example E117. MrgprX2 antagonist-3 can be used for the research of inflammatory disorders of the skin .

Sapienic acid sodium	Bacterial	Infection
Sapienic acid sodium is a fatty acid commonly found on the skin and in mucosa. Sapienic acid sodium has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid sodium is active against *Streptococcus sanguinis, Streptococcus mitis* and *Fusobacterium nucleatum* with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively .

MrgprX2 antagonist-4	Mas-related G-protein-coupled Receptor (MRGPR)	Inflammation/Immunology
MrgprX2 antagonist-4 is an MrgprX2 antagonist extracted from patent US20210128561A1, compound B-51 E117. MrgprX2 antagonist-4 can be used for the research of inflammatory disorders of the skin .

Palmitoyl serinol N-Palmitoyl serinol	Cannabinoid Receptor	Inflammation/Immunology
Palmitoyl serinol (N-Palmitoyl serinol) is an analog of the endocannabinoid N-palmitoyl ethanolamine (PEA). Palmitoyl serinol improves the epidermal permeability barrier in both normal and inflamed skin .

PEG-8 laurate	Biochemical Assay Reagents	Others
PEG-8 laurate is a single chain surfactant. PEG-8 laurate reduces the skin barrier, and acts as a penetration enhancer. PEG-8 laurate can be used to synthesize elastic vesicles .

Nonapeptide-1 acetate salt 2 Publications Verification Melanostatine-5 acetate salt	Melanocortin Receptor	Metabolic Disease Endocrinology Cancer
Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, is a selective antagonist of MC1R (K_i: 40 nM). Nonapeptide-1 acetate salt is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC₅₀: 2.5 nM and 11 nM, respectively). Nonapeptide-1 acetate salt inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer .

Nonapeptide-1 Melanostatine-5	Melanocortin Receptor	Metabolic Disease Endocrinology Cancer
Nonapeptide-1 (Melanostatine-5), a peptide hormone, is a selective antagonist of MC1R (K_i: 40 nM). Nonapeptide-1 is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC₅₀: 2.5 nM and 11 nM, respectively). Nonapeptide-1 inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer .

3,5,7-Trimethoxyflavone	Others	Inflammation/Immunology
3,5,7-Trimethoxyflavone, a flavonoid compound, can inhibit the TNF-α-induced high expression and secretion of MMP-1 by cells. 3,5,7-Trimethoxyflavone can be used to ameliorate skin damage .

Dermcidin-1L (human)	Antibiotic	Infection
Dermcidin-1L (human) is an antibiotic peptide secreted by sweat glands. Dermcidin-1L (human) has antimicrobial activity. Dermcidin-1L (human) can be used for the research of inflammatory skin disorders .

(R)-MrgprX2 antagonist-3	Mas-related G-protein-coupled Receptor (MRGPR)	Inflammation/Immunology
(R)-MrgprX2 antagonist-3 (compound E118) is an MrgprX2 antagonist extracted from patent WO2021092240A1, example E118. (R)-MrgprX2 antagonist-3 can be used for the research of inflammatory disorders of the skin .

JAK-IN-11	JAK	Inflammation/Immunology
JAK-IN-11 is a potent and selective JAK inhibitor extracted from patent WO2012122452A1, Compound II, has the potential for the skin disorders (such as cutaneous lupus) treatment . JAK-IN-11 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Melanotan I acetate MT-I acetate; [Nle4,D-Phe7]-α-MSH acetate	Melanocortin Receptor	Cancer
Melanotan I acetate is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I acetate is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I acetate can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I acetate can be used for sunlight-induced skin cancers research .

Antitumor photosensitizer-2	Others	Cancer
Antitumor photosensitizer-2 (Compound 11) is a potent photosensitizer. Antitumor photosensitizer-2 has outstanding photodynamic anti-tumor effects without obvious skin photo-toxicity, and can act as new agent candidates for photodynamic research .

Antitumor photosensitizer-1	Others	Cancer
Antitumor photosensitizer-1 (Compound 8) is a potent photosensitizer. Antitumor photosensitizer-1 has outstanding photodynamic anti-tumor effects without obvious skin photo-toxicity, and can act as new agent candidates for photodynamic research .

GLPG2534	IRAK	Inflammation/Immunology
GLPG2534 is an orally active and selective IRAK4 inhibitor, with IC₅₀ values of 6.4 nM and 3.5 nM for human and mouse IRAK4. GLPG2534 can be used for the research of inflammatory skin diseases .

PF-00956980	JAK	Inflammation/Immunology
PF-00956980 is a reversible pan-JAK inhibitor with IC₅₀ values of 2.2, 23.1 and 59.9 μM for JAK1, JAK2 and JAK3, respectively. PF-00956980 can be used in the research of lung and skin inflammatory diseases .

Amido Black 10B Naphthol Blue Black	Fluorescent Dye	Others
Amido Black 10B (Naphthol Blue Black) is a highly toxic azo dye for amino acid staining. Amido Black 10B can create several problems in the human respiratory system and may also cause skin and eye irritations .

Arotinoid Ro 13-6298; Arotinoid ethyl ester	RAR/RXR	Inflammation/Immunology Cancer
Arotinoid (RO 13-6298) is a retinoid, and acts as an orally active and highly potent agonist of retinoic acid receptors (RARs) with antipsoriatic effects. Arotinoid has antipapiltoma activity with an ED₅₀ of 0.05 mg/kg. Arotinoid can be used for the research of skin carcinomas .

AhR agonist 2	Aryl Hydrocarbon Receptor	Others
AhR agonist 2 (Compound 12a) is a potent agonist of aryl hydrocarbon receptor (AhR) with an EC₅₀ of 0.03 nM. AhR agonist 2 induces rapid nuclear enrichment of AhR, triggers the transcription of downstream genes and promote skin barrier repair. AhR agonist 2 has the potential for the research of psoriasis .

Clobetasone butyrate 1 Publications Verification	Glucocorticoid Receptor	Inflammation/Immunology
Clobetasone butyrate is a synthetic glucocorticoid and has topical anti-inflammatory activity especially in skin. Clobetasone butyrate can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis and psoriasis .

Cat. No.	Product Name

HY-L126

Nuclear Receptor Compound Library

665 compounds

Nuclear receptors (NR) are proteins found in cells that sense androgen and thyroid hormones and certain other molecules. They are ligand-activated transcription factors that participate in many aspects of human physiology and pathology, and regulate the expression of various important genes.

Nuclear receptors have become one of the main targets in the development of new drug strategies, providing a unique type of receptors for studying a variety of human diseases, such as breast cancers, skin disorders and diabetes. 13% of U.S. Food and Drug Administration (FDA) approved drugs target nuclear receptors.

MCE supplies a unique collection of 665 nuclear receptor inhibitors and activators, all of which have the identified inhibitory or activated effect on nuclear receptor. MCE Nuclear Receptor Library is a useful tool for drugs research related to cancer, skin disease and diabetes.

HY-L095

Mechanoreceptors Compound Library

254 compounds

Mechanoreceptors convert different stimuli from the outside into electrical signals, enabling us to quickly respond to our environment. Mechanoreceptors are distributed throughout the body, including in the skin, tendons, muscles, joint capsules and viscera. In addition to the channels of TRP and Piezo mentioned in the Nobel Prize, there are also targets such as KCNK, ENaC and ASIC2, which play an important role in the environment perception and homeostasis of living organisms.

MCE offers a unique collection of 254 compounds related to mechanoreceptors, which targeting different mechanoreceptors, such as TRP, Piezo, KCNK, ENaC, etc. MCE mechanoreceptors compound library is a powerful tool for studying mechanoreceptors and life perception.

HY-L060

Cytoskeleton Compound Library

1242 compounds

The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases.

MCE designs a unique collection of 1242 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

Cat. No.	Product Name	Type

HY-Y0695

Amido Black 10B Naphthol Blue Black	Protein Labeling
Amido Black 10B (Naphthol Blue Black) is a highly toxic azo dye for amino acid staining. Amido Black 10B can create several problems in the human respiratory system and may also cause skin and eye irritations .

HY-D1228

Pigment Red 22

Dyes

Pigment Red 22, a coloring agent, is used in the formulation of cleansing products, makeup, moisturizers, and night skin care products.

Cat. No.	Product Name	Type

HY-125809

4-(1-Phenylethyl)resorcinol	Biochemical Assay Reagents
4-(1-Phenylethyl)resorcinol is a skin lightening agent used in cosmetics. It works by inhibiting the production of melanin, the pigment that gives skin its color. This helps reduce the appearance of dark spots, hyperpigmentation and uneven skin tone. 4-(1-Phenylethyl)resorcinol is considered safe for cosmetic use and is approved for use in several countries.

HY-W010807

Hexadecyl palmitate

Biochemical Assay Reagents

Hexadecyl palmitate is an organic compound commonly used in the cosmetic industry as an emollient, thickener and skin conditioning agent. Cetyl palmitate is derived from a mixture of cetyl alcohol (a fatty alcohol) and palmitic acid (a saturated fatty acid). It is often used in skin care products such as moisturizers, lotions, and creams to improve their texture and Helps them glide smoothly on the skin. In addition to its use in cosmetics, cetyl palmitate is used in other industries including pharmaceuticals, food additives and lubricants. Overall, it's considered safe for use in personal care products, but like any other ingredient, it may cause irritation or an allergic reaction in some people.

HY-B1024

DL-Panthenol DL-Pantothenol; DL-Pantothenyl alcohol	Biochemical Assay Reagents
DL-Panthenol (DL-Pantothenol) is an alcohol derivative of pantothenyl acid. DL-Panthenol exerts eyelash protection effect. DL-Panthenol is widely used in the Skin and hair conditioner research .

HY-P2738

Collagens	Native Proteins
Collagens are extracellular matrix proteins and show many applications in food, cosmetic, pharmaceutical and biomedical industries. Collagens play an important role in the structure and function of skin, cartilage, bone and connective tissue .

HY-125920

Lauroylsarcosine sodium

Biochemical Assay Reagents

Lauroylsarcosine sodium is a surfactant commonly used in personal care and cosmetics such as shampoos, facial cleansers and toothpaste. It works by lowering the surface tension of water, allowing it to better penetrate and clean surfaces. Lauroylsarcosine sodium is considered safe for cosmetic use and is approved for use in several countries. However, it can cause skin irritation in high concentrations or with prolonged exposure.

HY-141582

Ceramide 3

N-Stearoyl phytosphingosine

Biochemical Assay Reagents

C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation.

HY-W127530

α-Tocopherol phosphate disodium

3 Publications Verification

alpha-Tocopherol phosphate disodium; TocP disodium; Vitamin E phosphate disodium

Biochemical Assay Reagents

α-Tocopherol phosphate (alpha-Tocopherol phosphate) disodium, a promising antioxidant, can protect against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate disodium possesses therapeutic potential in the inhibition of apoptosis and increases the migratory capacity of endothelial progenitor cells under high-glucose/hypoxic conditions and promotes angiogenesis .

HY-W250194

Luviquat FC 550

Biochemical Assay Reagents

Luviquat FC 550 is a cationic polymer commonly used in a variety of personal care and cosmetics. It is a viscous liquid containing quaternary ammonium groups which give it a positive charge. Luviquat FC 550 has a variety of properties suitable for these applications including its ability to provide conditioning, antistatic and film-forming properties to hair and skin. In addition, it is used as a binder in oral care products and as a flocculant in industrial water treatment.

HY-P3021

Human milk lysozyme	Biochemical Assay Reagents
Human milk lysozyme is the lysozyme found in human milk. Human milk lysozyme is thought to be a key defense factor in protecting the gastrointestinal tract of newborns against bacterial infection .

HY-W131101

Sorbitan tristearate

Drug Delivery

Sorbitan tristearate is a non-ionic surfactant, with a synergistic effect on skin permeability. Sorbitan tristearate can be used as an excipient, such as emulsifier. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .

HY-W099594

Benzalkonium bromide

Benzyldimethyldodecylammonium bromide

Biochemical Assay Reagents

N-Benzyl-N, N-dimethyldodecan-1-aminium bromide, also known as Benzalkonium Chloride (BAC), is a quaternary ammonium compound widely used as an antimicrobial and surfactant in various industries. BAC is commonly used as a disinfectant and antiseptic in a variety of products including hand sanitizers, disinfectant wipes and eye drops. Its ability to kill bacteria, viruses and fungi makes it an effective tool in preventing the spread of infection. BAC is also used as a preservative and disinfectant in the food industry. It is added to food packaging and processing equipment to prevent the growth of microorganisms and increase the shelf life of foods. Additionally, BACs are found in many household products such as cleaning solutions, fabric softeners and personal care products. Its surfactant properties allow it to be used to reduce surface tension and increase the effectiveness of cleaning agents. Although BAC has many uses, ingestion or exposure to high concentrations of BAC can cause skin irritation and other adverse effects.

Cat. No.	Product Name	Target	Research Area

HY-P3163

Hexapeptide-9	Peptides	Others
Hexapeptide-9 is a collagen peptide, with anti-aging activity. Hexapeptide-9 is commonly used as the ingredient in skin care products for improving the appearance of the skin .

HY-P0123

SPACE peptide 3 Publications Verification	Peptides	Others
SPACE peptide is a skin penetrating peptide (SPPs). SPACE peptide can enhance topical delivery of a macromolecule, hyaluronic acid .

HY-P5263

YYRADDA	Peptides	Others
YYRADDA is a polypeptide. YYRADDA stimulates the growth of collagen in the extracellular matrix of the skin. YYRADDA improves the appearance of the skin and promotes the healing of damaged skin .

HY-P5230

Manganese tripeptide-1	Peptides	Others
Manganese tripeptide-1 is a bioactive peptide with anti-wrinkle and reducing skin hyperpigmentation effect, and has been reported used as a cosmetic ingredient .

HY-P5236

Acetyl tetrapeptide-22

Peptides Others

Acetyl tetrapeptide-22 is a bioactive peptide with repair skin effect and has been reported used as a cosmetic ingredient .

HY-P3452

Tetrapeptide-30	Tyrosinase	Inflammation/Immunology
Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation .

HY-P3915

Esculentin 1A

Bacterial Infection

Esculentin 1A is a frog skin-derived antimicrobial peptide (AMP) with potent in vitro anti-Pseudomonas activity .

HY-A0299

H-Gly-Pro-Hyp-OH Tripeptide 29	Peptides	Others
HGly-Pro-Hyp-OH (Tripeptide 29) is an orally active bioactive peptide against UVB-induced skin aging and has been reported used as a cosmetic ingredient ^[1]

HY-P5256

Oligopeptide-20

Bacterial Others

Oligopeptide-20 is a bioactive peptide with skin repair effect and has been reported used as a cosmetic ingredient .
HY-P5257

Oligopeptide-24

CG-EDP3
Peptides Others

Oligopeptide-24 (CG-EDP3) s a bioactive peptide with skin repair effect and has been reported used as a cosmetic ingredient .

HY-P5232

Tetrapeptide-21	Peptides	Others
Tetrapeptide-21 is a bioactive peptide with anti-wrinkle and and reducing skin hyperpigmentation effect, and has been reported used as a cosmetic ingredient .

HY-P5254

Hexapeptide-3

Peptides Metabolic Disease

Hexapeptide-3isa bioactive peptide with repair skin effect and has been reported used as a cosmetic ingredient .

HY-P0097A

Nonapeptide-1 acetate salt 2 Publications Verification Melanostatine-5 acetate salt	Melanocortin Receptor	Metabolic Disease Endocrinology Cancer
Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, is a selective antagonist of MC1R (K_i: 40 nM). Nonapeptide-1 acetate salt is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC₅₀: 2.5 nM and 11 nM, respectively). Nonapeptide-1 acetate salt inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer .

HY-P0097

Nonapeptide-1 Melanostatine-5	Melanocortin Receptor	Metabolic Disease Endocrinology Cancer
Nonapeptide-1 (Melanostatine-5), a peptide hormone, is a selective antagonist of MC1R (K_i: 40 nM). Nonapeptide-1 is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC₅₀: 2.5 nM and 11 nM, respectively). Nonapeptide-1 inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer .

HY-P4848

Dermcidin-1L (human)	Antibiotic	Infection
Dermcidin-1L (human) is an antibiotic peptide secreted by sweat glands. Dermcidin-1L (human) has antimicrobial activity. Dermcidin-1L (human) can be used for the research of inflammatory skin disorders .

HY-N2466A

Melanotan I acetate MT-I acetate; [Nle4,D-Phe7]-α-MSH acetate	Melanocortin Receptor	Cancer
Melanotan I acetate is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I acetate is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I acetate can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I acetate can be used for sunlight-induced skin cancers research .

HY-P0046

Glycyl-L-histidyl-L-lysine 2 Publications Verification	Peptides	Neurological Disease Inflammation/Immunology
Glycyl-L-histidyl-L-lysine is a tripeptide consisting of glycine, L-histidine and L-lysine residues joined in sequence. Glycyl-L-histidyl-L-lysine is a hepatotropic immunosuppressor and shows anxiolytic effect. Glycyl-L-histidyl-L-lysine and its copper complexes show good skin tolerance .

HY-P3121

Caprooyl-tetrapeptide-3 acetate	Peptides	Metabolic Disease
Caprooyl-tetrapeptide-3 acetate is used for fine lines and wrinkle reduction. Caprooyl-tetrapeptide-3 acetate stimulates the expression of collagen VII and laminin-5 in a model of corticoid-induced skin ageing .

HY-P4088

LyP-2	Peptides	Cancer
LyP-2 is a peptide that homes to tumor lymphatics. LyP2 homes to lymphatics of C8161 melanomas and cervical carcinomas and K14-HPV16 skin, but not to MDA-MB435 tumors, showing heterogeneity in the molecular markers of tumor cells and lymphatics .

HY-P3410

Trichomide A	SHP2 Phosphatase	Inflammation/Immunology
Trichomide A is a potent activator of SHP2. Trichomide A is a natural cyclodepsipeptide. Trichomide A displays immunosuppressive activity against activated T lymphocyte–mediated immune responses in Con A-activated T cells. Trichomide A have the potential for the research of immune-related skin diseases .

HY-W141881

N-Lauroylsarcosine	Biochemical Assay Reagents	Others
N-lauroylsarcosine is an anionic surfactant, and can be used as a permeation enhancer. The mixture of N-lauroylsarcosine in 25-50% ethanol acts synergistically to increase skin permeability, which may be useful for transdermal drug delivery research .

HY-N2466

Melanotan I 1 Publications Verification MT-I; [Nle4,D-Phe7]-α-MSH	Melanocortin Receptor	Neurological Disease Cancer
Melanotan I is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I can be used for the research of sun-induced skin cancer, melanoma, inflammation and male erectile dysfunction .

HY-P0244

Dermorphin

Opioid Receptor Neurological Disease

Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain .
HY-P0244A

Dermorphin TFA

Opioid Receptor Neurological Disease

Dermorphin TFA is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain .

HY-P3645

(Nle4)-α-MSH	Melanocortin Receptor	Others
(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment .

HY-P1626

Acetyl tetrapeptide-15	Opioid Receptor	Neurological Disease
Acetyl tetrapeptide-15 is a synthetic peptide used in the cosmetics for sensitive skin. Acetyl tetrapeptide-15 is derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist with selective anti-nociceptive effect. Acetyl tetrapeptide-15 reduces skin hyperreactivity producing inflammatory, chronic and neuropathic pain, by increasing the threshold of neuronal excitability in μ-opioid receptor via an endorphin-like pathway .

HY-P1447

Exendin-3/4 (64-86)	Peptides	Metabolic Disease
Exendin-3/4 (64-86) is a polypeptide from patent CN 106029087 A. The incretin receptor ligands are derived from multiple skin toxicity Shan exosomes -3 skin of SDGTFTSDLSKQM Di EAVRLFIEWLKNGGPSSGAPPPS.

HY-P5641

Pleurocidin

Bacterial Infection

Pleurocidin is an antibacterial peptide derived from skin secretions of Winter Flounder .
HY-P5659

Brevinin-1

Peptides Infection

Brevinin-1 is an antimicrobial peptide derived from the skin secretions of Rana esculenta .
HY-P5660

Brevinin-2

Peptides Infection

Brevinin-2 is an antimicrobial peptide derived from the skin secretions of Rana esculenta .
HY-P5674

Bombinin H2

Bacterial Infection

Bombinin H2 is an antimicrobial peptide derived from the skin of moth Bombina variegata .
HY-P5677

Bombinin H5

Bacterial Infection

Bombinin H5 is an antimicrobial peptide derived from the skin of moth Bombina variegata .
HY-P5662

Brevinin-2EC

Peptides Infection

Brevinin-2EC is an antimicrobial peptide derived from the skin secretions of Rana esculenta .

HY-P4200

Lugdunin	Antibiotic Bacterial	Infection
Lugdunin is an antibiotic peptide. Lugdunin inhibits bacteria by dissipating their membrane potential. Lugdunin is active against Gram-positive bacteria, such as S. aureus, and reduces S. aureus skin and nasal colonization. Lugdunin induces LL-37 and CXCL8/MIP-2 in human keratinocytes and mouse skin .

HY-P5587

Dermaseptin-S5

Fungal Infection

Dermaseptin-S5 is an antimicrobial peptide derived from frog skin against filamentous fungi .
HY-P5588

Dermaseptin-S4

Fungal Infection

Dermaseptin-S4 is an antimicrobial peptide derived from frog skin against filamentous fungi .
HY-P5590

Dermaseptin-S3

Fungal Infection

Dermaseptin-S3 is an antimicrobial peptide derived from frog skin against filamentous fungi .
HY-P5593

Dermaseptin-S2

Fungal Infection

Dermaseptin-S2 is an antimicrobial peptide derived from frog skin against filamentous fungi .
HY-P5594

Dermaseptin-S1

Fungal Infection

Dermaseptin-S1 is an antimicrobial peptide derived from frog skin against filamentous fungi .
HY-P5656

Brevinin-1Ea

Peptides Infection

Brevinin-1Ea is an antimicrobial peptide derived from the skin secretions of Rana esculenta .
HY-P5658

Brevinin-1E

Peptides Infection

Brevinin-1E is an antimicrobial peptide derived from the skin secretions of Rana esculenta .

HY-P1577

Dermorphin Analog	Opioid Receptor	Inflammation/Immunology
Dermorphin Analog is an analog of Dermorphin. Dermorphin is a natural heptapeptide μ-opioid receptor agonist found in amphibian skin.

HY-P5633

Bombinin-like peptide 2

BLP-2
Peptides Infection

Bombinin-like peptide 2 is an antimicrobial peptide derived from skin secretions of asian toad Bombina orientalis .
HY-P5634

Bombinin-like peptide 3

BLP-3
Peptides Infection

Bombinin-like peptide 3 is an antimicrobial peptide derived from skin secretions of asian toad Bombina orientalis .
HY-P5635

Bombinin-like peptide 4

BLP-4
Peptides Infection

Bombinin-like peptide 4 is an antimicrobial peptide derived from skin secretions of asian toad Bombina orientalis .
HY-P0253

Xenopsin

Peptides Metabolic Disease

Xenopsin, a neurotensin-like octapeptide from Xenopus laevis skin . Xenopsin is an inhibitor of Tetragastrin stimulated gastric acid secretion .
HY-P5585

Dermaseptin-B4

Peptides Infection

Dermaseptin-B4 is an antimicrobial peptide derived from the skin secretions of the South American frog Phyllomedusa bicolor .
HY-P5586

Dermaseptin-B5

Peptides Infection

Dermaseptin-B5 is an antimicrobial peptide derived from the skin secretions of the South American frog Phyllomedusa bicolor .

HY-P0263

Dermaseptin	Bacterial Fungal Antibiotic	Infection
Dermaseptin, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration .

HY-P0253A

Xenopsin TFA	Peptides	Metabolic Disease
Xenopsin TFA, a neurotensin-like octapeptide from Xenopus laevis skin . Xenopsin TFA is an inhibitor of Tetragastrin stimulated gastric acid secretion .

Cat. No.	Product Name	Target	Research Area

HY-P99519

Vixarelimab KPL-716	Interleukin Related	Inflammation/Immunology
Vixarelimab (KPL-716) is a human anti-oncostatin M (OSM) monoclonal antibody that binds to the beta chain of the OSM receptor and inhibits IL-31 and OSM signalling. Vixarelimab can be used in studies of inflammatory skin diseases such as atopic dermatitis and itchy nodular rash .

HY-P99203

Cemiplimab	PD-1/PD-L1	Cancer
Cemiplimab (Anti-Human PD-1) is a high-affinity programmed death receptor-1 (PD-1) monoclonal IgG4 antibody that blocks PD-1/PD-L1-mediated T-cell suppression. Cemiplimab is commonly used in squamous cell skin cancer research .

HY-P99462

Barzolvolimab CDX 0159	c-Kit	Inflammation/Immunology
Barzolvolimab (CDX 0159) is a humanized anti-KIT IgG1 monoclonal antibody. Barzolvolimab specificity and potently inhibits KIT activation by SCF. Barzolvolimab can reduce skin mast cells and disease activity in chronic inducible urticaria .

HY-P99659

Imsidolimab ANB 019	Interleukin Related	Inflammation/Immunology
Imsidolimab (ANB 019) is a high-affinity, humanized monoclonal antibody of anti-IL-36R. Imsidolimab antagonizes IL-36 cytokine signal transduction. Imsidolimab has potential application in generalized pustular psoriasis (GPP) and other inflammatory skin diseases .

Species:	Human (2)
Tag:	His (2) GST (1)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70316

	Elafin/Trappin-2 Protein, Human (HEK293, His) rHuElafin, His; Elafin; Elastase-Specific Inhibitor; ESI; Peptidase Inhibitor 3; PI-3; Protease inhibitor WAP3; skin-Derived Antileukoproteinase; SKALP; WAP Four-Disulfide Core Domain Protein 14; PI3; WAP3; WFDC14	Human	HEK293
	Elafin/Trappin-2, a skin-specific inhibitor of neutrophil and pancreatic elastase, safeguards tissues against elastase-mediated proteolysis. Its inhibitory range extends to the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor. Elafin/Trappin-2 also weakly inhibits Kv11.1/KCNH2/ERG1 and transient receptor potential cation channel subfamily V member 1 (TRPV1), as reported in studies. Elafin/Trappin-2 Protein, Human (HEK293, His) is the recombinant human-derived Elafin/Trappin-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Elafin/Trappin-2 Protein, Human (HEK293, His) is 95 a.a., with molecular weight of 13-15 kDa.

HY-P76760

	CALML5 Protein, Human (His) Calmodulin-like protein 5; Calmodulin-like skin protein; CLSP	Human	E. coli
	CALML5 Protein, known for its calcium-binding capacity, potentially participates in keratinocyte terminal differentiation, indicating a role in skin cell maturation. Its association with transglutaminase 3 suggests collaboration in skin development functions. CALML5's calcium-binding property likely contributes to its regulatory role in keratinocyte differentiation, emphasizing its significance in intricate molecular mechanisms governing skin cell maturation. CALML5 Protein, Human (His-GST) is the recombinant human-derived CALML5 protein, expressed by E. coli, with N-His, N-GST labeled tag. The total length of CALML5 Protein, Human (His-GST) is 146 a.a., with molecular weight of ~43 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P81227

Collagen I Antibody Collagen type I; Alpha 1 type I collagen; Alpha 2 type I collagen; COL1A1; COL1A2; Collagen I alpha 1 polypeptide; Collagen I alpha 2 polypeptide; Collagen Of skin Tendon And Bone; Collagen Type 1; Collagen type I alpha 1; Collagen type I alpha 2; OI4; Osteogenesis Imperfecta Type IV; Pro alpha 1(I) collagen; Type I procollagen; CO1A1_HUMAN.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human, Mouse, Rat, Rabbit(predicted: Chicken, Dog, Cow, Sheep)
Collagen I Antibody is an unconjugated, approximately 130 kDa, rabbit-derived, anti-Collagen I polyclonal antibody. Collagen I Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, rat, rabbit, and predicted: chicken, dog, cow, sheep background without labeling.

Cat. No.	Product Name		Classification

HY-U00318

JAK-IN-11		Alkynes
JAK-IN-11 is a potent and selective JAK inhibitor extracted from patent WO2012122452A1, Compound II, has the potential for the skin disorders (such as cutaneous lupus) treatment . JAK-IN-11 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-155505

AHR agonist 4		Alkynes
AHR agonist 4 (compound 24e) is an agonist of Aryl hydrocarbon receptor (AHR), assocaited with the immune balance of Th17/22 and Treg cells. AHR agonist 4 serves as a lead compound for anti-psoriasis drug, alleviates imiquimod (IMQ)-induced psoriasis-like skin lesion . AHR agonist 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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