spin

By Targets:	Angiotensin-converting Enzyme (ACE) (1) COX (2) Epigenetic Reader Domain (3) NO Synthase (1) Reactive Oxygen Species (6) SARS-CoV (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (4) Infection (1) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114713

POBN

4-POBN
Others Others

POBN (4-POBN) is a cell permeable, hydrophilic spin trap that can be used to detect free radical adducts .

POBN 4-POBN	Others	Others
POBN (4-POBN) is a cell permeable, hydrophilic spin trap that can be used to detect free radical adducts .

HY-135152

CYPMPO	Reactive Oxygen Species	Cancer
CYPMPO is a spin-trapping reagent. CYPMPO, a cyclic DEPMPO-type nitrone, is evaluated for spin-trapping capabilities toward hydroxyl and superoxide radicals. anti-oxidant and anti-tumor activity .

HY-RS13675

SPIN1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SPIN1 Human Pre-designed siRNA Set A contains three designed siRNAs for SPIN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SPIN1 Human Pre-designed siRNA Set A SPIN1 Human Pre-designed siRNA Set A

HY-RS13676

SPIN3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SPIN3 Human Pre-designed siRNA Set A contains three designed siRNAs for SPIN3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SPIN3 Human Pre-designed siRNA Set A SPIN3 Human Pre-designed siRNA Set A

HY-RS13677

SPIN4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SPIN4 Human Pre-designed siRNA Set A contains three designed siRNAs for SPIN4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SPIN4 Human Pre-designed siRNA Set A SPIN4 Human Pre-designed siRNA Set A

HY-23033

Tempone-H	Others	Neurological Disease
Tempone-H may be used as a spin trap in chemical and biological systems to quantify peroxynitrite and superoxide radical formation. Ferric and cupric ions are effective oxidants of Tempone-H .

HY-129214

(2S,3R)-DEPMPO-Biotin	Reactive Oxygen Species	Inflammation/Immunology
(2S,3R)-DEPMPO-Biotin is a spin trapping agent consists of DEPMPO (HY-120976) and Biotin (HY-B0511). (2S,3R)-DEPMPO-Biotin captures macromolecule free radicals in lesions .

HY-121137

BMPO BocMPO	Others	Others
BMPO (BocMPO) is a cell-permeable superior spin trap with favorable chemical and spectroscopic features. BMPO (BocMPO) can be used for detecting thiyl radicals, hydroxyl radicals, superoxide anions and glutathiyl radicals .

HY-128463

N-tert-Butyl-α-phenylnitrone	COX Reactive Oxygen Species	Neurological Disease Metabolic Disease Inflammation/Immunology
N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier .

HY-125837A

MS31 trihydrochloride	Epigenetic Reader Domain	Cancer
MS31 trihydrochloride is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 trihydrochloride potently inhibits the interactions between SPIN1 and H3K4me3 (IC₅₀=77 nM, AlphaLISA; 243 nM, FP). MS31 trihydrochloride selectively binds Tudor domain II of SPIN1 (K_d=91 nM). MS31 trihydrochloride potently inhibits binding of trimethyllysine-containing peptides to SPIN1, and is not toxic to nontumorigenic cells .

HY-114207

VinSpinIn	Epigenetic Reader Domain	Others
VinSpinIn is a Spindlin1 inhibitor (K_D: 9.9 nM for SPIN1_49-262). VinSpinIn is a chemical probe for tudor domain of Spindlin1. VinSpinIn can be used to study chromatin function .

HY-125837

MS31	Epigenetic Reader Domain	Cancer
MS31 is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 potently inhibits the interactions between SPIN1 and H3K4me3 (IC₅₀=77 nM, AlphaLISA; 243 nM, FP). MS31 selectively binds Tudor domain II of SPIN1 (K_d=91 nM). MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1. MS31 is not toxic to nontumorigenic cells .

HY-107690

DMPO

Reactive Oxygen Species NO Synthase Inflammation/Immunology

DMPO is a cell permeable hydrophillic spin trap agent for superoxide detection .
HY-163460

MS8535

Others Others

MS8535 is a SPIN1 selective inhibitor, with an IC₅₀ of 0.2 μM .

DMPO	Reactive Oxygen Species NO Synthase	Inflammation/Immunology
DMPO is a cell permeable hydrophillic spin trap agent for superoxide detection .

MS8535	Others	Others
MS8535 is a *SPIN1* selective inhibitor, with an IC₅₀ of 0.2 μM .

HY-161068

hACE2/SP-IN-1	SARS-CoV Angiotensin-converting Enzyme (ACE)	Infection
hACE2/SP-IN-1 (compound 7a) is a dual inhibitor of hACE2 and coronavirus spike protein. hACE2/SP-IN-1 can bind to the spike protein and block cell entry, preventing SARS-CoV-2 from infecting human cells .

HY-147166

2-Carboxyanthracene MTSEA amide

Others Others

2-Carboxyanthracene MTSEA amide is an MTS derivative of anthracene. 2-Carboxyanthracene MTSEA Amide is a special spin-marker .

2-Carboxyanthracene MTSEA amide	Others	Others
2-Carboxyanthracene MTSEA amide is an MTS derivative of anthracene. 2-Carboxyanthracene MTSEA Amide is a special spin-marker .

HY-13244

Disufenton sodium NXY-059	Reactive Oxygen Species	Neurological Disease
Disufenton sodium (NXY-059) is the disulfonyl derivative of the neuroprotective spin trap phenylbutynitrone(PBN), both NXY-059, its parent PBN and their hydrolysis/oxidation product MNT are very powerful scavengers of free radicals.

HY-120976

DEPMPO	Others	Cancer
cDEPMPO is a potent anticancer proagent. High concentrations of DEPMPO spin-trap the ·OH radical together with aryl radicals arising from one-electron reduced BTO (benzotriazine 1,4-di-N-oxide) compounds .

HY-128463S

N-tert-Butyl-α-phenylnitrone-d14	COX Reactive Oxygen Species
N-tert-Butyl-α-phenylnitrone-d₁₄ is the deuterium labeled N-tert-Butyl-α-phenylnitrone[1]. N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier[2][3][4][5].

Species:	Human (3)
Tag:	His (1) Tag Free (1) GST (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P77099

	NCKIPSD Protein, Human (His) NCK-interacting protein with SH3 domain; VIP54; WISH; AF3P21; spin90	Human	E. coli
	NCKIPSD Protein, vital for stress fiber formation induced by active DRF1, stimulates N-WASP-induced ARP2/3 complex activation, independent of CDC42. Implicated in sarcomere maintenance, myofibril assembly, actin polymerization, and angiogenesis. Associates with vimentin, desmin, NCK, GRB2, and interacts with Helicobacter pylori toxin vacA, FHOD1, FASLG, and TMIGD2, showcasing its diverse cellular interactions. NCKIPSD Protein, Human (His) is the recombinant human-derived NCKIPSD protein, expressed by E. coli, with N-His labeled tag. The total length of NCKIPSD Protein, Human (His) is 244 a.a., with molecular weight of ~33-45 kDa.

HY-P701841

	SPIN4 Protein, Human spin4; spindlin-4	Human	E. coli
	The SPIN4 protein exhibits H3K4me3 binding activity, demonstrating affinity for lysine 4 trimethylated histone H3. This unique combination suggests a role in recognizing specific chromatin modifications, potentially regulating gene expression or chromatin dynamics. SPIN4 Protein, Human is the recombinant human-derived SPIN4 protein, expressed by E. coli , with tag free. The total length of SPIN4 Protein, Human is 248 a.a., .

HY-P701840

	SPIN4 Protein, Human (His) spin4; spindlin-4	Human	E. coli
	The SPIN4 protein exhibits H3K4me3 binding activity, demonstrating affinity for lysine 4 trimethylated histone H3. This unique combination suggests a role in recognizing specific chromatin modifications, potentially regulating gene expression or chromatin dynamics. SPIN4 Protein, Human (His) is the recombinant human-derived SPIN4 protein, expressed by E. coli , with N-6*His labeled tag. The total length of SPIN4 Protein, Human (His) is 248 a.a., .


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Cat. No.	Product Name	Chemical Structure

HY-128463S

N-tert-Butyl-α-phenylnitrone-d14
N-tert-Butyl-α-phenylnitrone-d₁₄ is the deuterium labeled N-tert-Butyl-α-phenylnitrone[1]. N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier[2][3][4][5].

N-tert-Butyl-α-phenylnitrone-d14

N-tert-Butyl-α-phenylnitrone-d₁₄ is the deuterium labeled N-tert-Butyl-α-phenylnitrone[1]. N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier[2][3][4][5].

Cat. No.	Product Name	Application	Reactivity

HY-P83523

General Transcription Factor II I Antibody (YA3268) GTF2I; BAP135; WBSCR6; General transcription factor II-I; GTFII-I; TFII-I; Bruton tyrosine kinase-associated protein 135; BAP-135; BTK-associated protein 135; SRF-Phox1-interacting protein; spin; Williams-Beuren syndrome chromosomal region	WB, IHC-F, IHC-P, ICC/IF	Human

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