tPA

By Targets:	Androgen Receptor (1) Antibiotic (1) AP-1 (1) Biochemical Assay Reagents (2) EBV (5) ERK (1) Ferroptosis (1) Fluorescent Dye (2) GABA Receptor (1) Glucosidase (1) HSV (2) Isotope-Labeled Compounds (1) NF-κB (1) PAI-1 (5) PKC (4) Progesterone Receptor (1) Prostaglandin Receptor (1) Reactive Oxygen Species (1) Ser/Thr Protease (8) SphK (1) STAT (2)
By Research Areas:	Cancer (15) Cardiovascular Disease (6) Endocrinology (1) Infection (6) Inflammation/Immunology (15) Metabolic Disease (2) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18739

Phorbol 12-myristate 13-acetate Maximum Cited Publications 243 Publications Verification PMA; tPA; Phorbol myristate acetate	PKC SphK NF-κB	Inflammation/Immunology
Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator . Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells .

HY-19505

TPA-023B
TPA-023B is a high-affinity and orally active GABA_A receptor α2/α3 subtype (K_is of 0.73 nM/2 nM) partial agonist and a α1 subtype (K_i of 1.8 nM) antagonist. TPA-023B has non-sedating anxiolytic-like properties .

HY-101640

TPA 023

GABA Receptor Neurological Disease

TPA 023 is a GABAA α2/α3 subtype-selective agonist, with K_i of 0.19-0.41 nM.

TPA 023	GABA Receptor	Neurological Disease
TPA 023 is a GABAA α2/α3 subtype-selective agonist, with K_i of 0.19-0.41 nM.

HY-157779

TPA-NAC	Reactive Oxygen Species	Metabolic Disease
TPA-NAC is a nonfluorogenic prodrug by introducing N-acetyl-L-cysteine (NAC) into a conjugated acceptor skeleton. TPA-NAC is capable of fluorogenic selective labeling of HSA .

HY-106029

4α-TPA

α-tPA
Others Cancer

4α-TPA is an inactive form of TPA, and is used as a negative control for TPA-activated events .
HY-P5981

Chromozym t-PA

Biochemical Assay Reagents Others

Chromozym t-PA can be used for determination of t-PA (tissue plasminogen activator) concentration

4α-TPA α-tPA	Others	Cancer
4α-TPA is an inactive form of TPA, and is used as a negative control for TPA-activated events .

Chromozym t-PA	Biochemical Assay Reagents	Others
Chromozym t-PA can be used for determination of t-PA (tissue plasminogen activator) concentration

HY-108845

Tenecteplase TNK-tPA	Others	Metabolic Disease
Tenecteplase (TNK-tPA) is a modified tissue plasminogen activator. Tenecteplase (TNK-tPA) can be used for acute ischaemic stroke diseases research .

HY-163286

BODIQPy-TPA	Fluorescent Dye Ferroptosis	Others
BODIQPy-TPA is a lipophilic probes, which induces ferroptosis in B16 and HepG2 cells upon light irradiation through lipid peroxidation. BODIQPy-TPA reveals a maximum absorption wavelength of 488 nm and a maximum emission wavelength above 640 nm .

HY-163287

QPy-TPA	Fluorescent Dye	Others
QPy-TPA is a lipopjilc probes, which induces non-ferroptotic cell death and lipid dynamic regularion in B16 and HepG2 cells upon light irradiation. QPy-TPA reveals a maximum absorption wavelength of 400 nm and a maximum emission wavelength of 590 nm .

HY-108602

Bryostatin 3	PKC	Cancer
Bryostatin 3, a macrocyclic lactone, is a protein kinase C activator, with a K_i of 2.75 nM. Bryostatin 3 can block 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibition of cell proliferation, yet did not block TPA-enhanced cell-substratum adhesion .

HY-N7563

α-Toxicarol	EBV	Infection Cancer
α-Toxicarol is a potent inhibitor of EBV.α-Toxicarol significantly inhibits mouse skin tumor in vivo. α-Toxicarol inhibits the TPA-induced EBV-EA activation .

HY-N4024

Hyptadienic acid	Others	Inflammation/Immunology
Hyptadienic acid is a triterpene acid that can be isolated from the leaves of Perilla frutescens. Hyptadienic acid inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice with an ID₅₀ value of 0.13 mg/ear. Hyptadienic acid can be used for the research of inflammation .

HY-114015

APC-6860	Ser/Thr Protease	Cancer
APC-6860 is a trypsin-like serine proteases inhibitor with k_i values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has k_i values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer .

HY-N7691

3,29-O-Dibenzoyloxykarounidiol Karounidiol dibenzoate	EBV	Infection Cancer
3,29-O-Dibenzoyloxykarounidiol (Karounidiol dibenzoate) is a triterpene benzoate isolated from the fruit of Momordica grosvenori. 3,29-O-Dibenzoyloxykarounidiol has potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induced by tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) .

HY-120516

CDE-096	PAI-1	Cardiovascular Disease
CDE-096 is a potent inhibitor of PAI-1. CDE-096 prevents PAI-1 from inactivating tPA and uPA with similar potency (IC₅₀=30 and 25 nM, respectively) and is active against glycosylated PAI-1, as well as PAI-1 derived from several species (IC₅₀=19, 22 and 18 nM for murine, rat, and Porcine PAI-1, respectively) .

HY-111056

UK122	Ser/Thr Protease	Cancer
UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC₅₀ of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC₅₀>100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion .

HY-N11020

Cabenoside D	EBV	Infection Inflammation/Immunology
Cabenoside D (compound 8) is a triterpenoid glycoside, which can be isolated from the methanol extract of lichen root. Cabenoside D shows anti-inflammatory activity and inhibits inflammation induced by 12-O-tetracylacyl hormone-13-acetate (TPA) in mice. Cabenoside D also inhibits TPA-induced Epstein-Barr virus (EBV) early antigen (EBV-EA) activation .

HY-160070

Phorbol-12,13-didecanoate

Others Cancer

Phorbol-12,13-didecanoate is an anti-viral TPA compound and a tumor promoter. It can cause changes in actin-containing structures ^{[1] ^.}

Phorbol-12,13-didecanoate	Others	Cancer
Phorbol-12,13-didecanoate is an anti-viral TPA compound and a tumor promoter. It can cause changes in actin-containing structures ^{[1] ^.}

HY-N12467

24-Methylcholesterol	Others	Inflammation/Immunology
24-Methylcholesterol is a trans-ferulate ester that can be isolated from rice bran. 24-Methylcholesterol significantly inhibited TPA-induced inflammation .

HY-13772

Valrubicin 1 Publications Verification AD-32	PKC Antibiotic	Inflammation/Immunology Cancer
Valrubicin is a chemotherapy agent, inhibits TPA- and PDBu-induced PKC activation with IC₅₀s of 0.85 and 1.25 μM, respectively, and has antitumor and antiinflammatory activity.

HY-W018781

Benzamidine hydrochloride 2 Publications Verification	Ser/Thr Protease	Cancer
Benzamidine hydrochloride is a trypsin-like serine proteases with K_is of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively .

HY-I0508

Phthalic acid 2 Publications Verification	Biochemical Assay Reagents	Others
Phthalic acid is the final common metabolite of phthalic acid esters (PAEs). Phthalic acid can be used for the synthesis of synthetic agents, such as isophthalic acid (IPA), and terephthalic acid (TPA). Phthalic acid has applications in the preparation of phthalate ester plasticizers .

HY-114330A

ZK824859 hydrochloride	PAI-1 Ser/Thr Protease	Inflammation/Immunology
ZK824859 hydrochloride is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC₅₀s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively .

HY-126361

ZK824190	Ser/Thr Protease PAI-1	Inflammation/Immunology
ZK824190 is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC₅₀s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively .

HY-114330

ZK824859	PAI-1 Ser/Thr Protease	Inflammation/Immunology
ZK824859 is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC₅₀s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively .

HY-126361A

ZK824190 hydrochloride	Ser/Thr Protease PAI-1	Inflammation/Immunology
ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC₅₀s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively .

HY-N8873

Silychristin B	Others	Cancer
Silychristin B is an antitumor promoter. Silychristin B inhibits TPA induced Epstein-Barr virus early antigen (EBV-EA) induction. Silychristin B can be isolated from milk thistle .

HY-W087937

Benzamidine hydrochloride hydrate 2 Publications Verification Benzenecarboximidamide hydrochloride hydrate	Ser/Thr Protease	Cancer
Benzamidine (Benzenecarboximidamide) hydrochloride hydrate is a reversible competitive trypsin-like serine proteases inhibitor with K_is of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively .

HY-N3261

Methyllinderone	AP-1 ERK STAT	Inflammation/Immunology Cancer
Methyllinderone is an inhibitor of AP-1/STAT/ERK. Methyllinderone has anti-inflammatory effect. Methyllinderone reduce the invasion and migration rate of TPA-stimulated MCF-7 cells. Methyllinderone can be used in study breast cancer metastasis .

HY-I0508S

Phthalic acid-d4	Isotope-Labeled Compounds	Others
Phthalic acid-d₄ is the deuterium labeled Phthalic acid. Phthalic acid is the final common metabolite of phthalic acid esters (PAEs). Phthalic acid can be used for the synthesis of synthetic agents, such as isophthalic acid (IPA), and terephthalic acid (TPA). Phthalic acid has applications in the preparation of phthalate ester plasticizers[1].

HY-160615

TP receptor antagonist-1	Prostaglandin Receptor	Cardiovascular Disease Inflammation/Immunology
TP receptor antagonist-1 (compound 7m) is a thromboxane A₂ receptor (TP receptor) antagonist, with IC₅₀ values of 9.46 μM for *TPa* and 8.49 μM for TPb, respectively. TP receptor antagonist-1 can be used for the research of cardiovascular disease .

HY-100983

Protein kinase inhibitor H-7 dihydrochloride	PKC	Cancer
Protein kinase inhibitor H-7 dihydrochloride is a potent PKC (protein kinase C) inhibitor. At 100 μM, Protein kinase inhibitor H-7 dihydrochloride completely inhibits both *TPA* (skin tumour promoter, 12-O-tetradecanoylphorbol-13-acetate) and phospholipase C-induced ODC (ornithine decarboxylase) .

HY-163176

WB518	STAT	Inflammation/Immunology
WB518 is a potent STAT3 inhibitor. WB518 effectively inhibits STAT3 activation and Keratin 17 expression. WB518 effectively alleviates imiquimod (HY-B0180) and TPA (HY-18739)-induced animal psoriasis by inhibiting STAT3 phosphorylation and Keratin 17 .

HY-P2821

Plasminogen, Human plasma	Others	Inflammation/Immunology
Plasminogen, Human plasma is a secreted protein that upon cleavage by urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA) is converted to plasmin, a broad range protease capable of cleaving fibrin and other ECM components. Plasminogen also is a proinflammatory regulator that accelerates the healing of acute and diabetic wounds. Plasminogen can be used in studies of wound healing, inflammation and hypoplasminogenemia .

HY-B0111

Drospirenone Dihydrospirorenone	Progesterone Receptor Androgen Receptor	Endocrinology Cancer
Drospirenone (Dihydrospirorenone) is an orally active fourth-generation progestin that interacts with the progesterone receptor (PR) and androgen receptor (AR). Drospirenone significantly decreases both plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) via the AR. Drospirenone can produce DNA damage in bone marrow cells of female mice. .

HY-N7040

11-Deoxymogroside IIE	HSV	Infection
11-Deoxymogroside IIE is a cucurbitane glycoside, isolated from Siraitia grosvenorii fruits. 11-Deoxymogroside IIE has inhibitory effect against Epstein Barr virus (EBV-EA) activation induced by TPA, shows weak inhibitory effect on (+/-)-(E)-methyl1-2-[E-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR1), a NO donor .

HY-B1231

Heptaminol hydrochloride RP-2831 hydrochloride	Others	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Heptaminol (RP-2831) hydrochloride is a vasoconstrictor used in the study of hypotension, especially orthostatic hypotension. Heptaminol is also a skin cancer proliferation inhibitor that inhibits immune inflammation induced by the tumor promoting factor 12-O-tetradecanoylphorbol-13-acetate (TPA) in an NO-dependent manner. Heptaminol also acts as a sympathomimetic amine, exerting indirect sympathetic effects. Heptaminol is also an antagonist of catecholamine release and uptake and can increase intracellular free calcium levels .

HY-N10439

3β-Acetoxy-hop-22(29)-ene	Glucosidase	Inflammation/Immunology
3β-Acetoxy-hop-22(29)-ene (compound 1) is a potent anti-inflammatory agent. 3β-Acetoxy-hop-22(29)-ene shows high inhibitory activity of yeast α-glucosidase, with an IC₅₀ of 5.74 μM. 3β-Acetoxy-hop-22(29)-ene inhibits MPO (myeloperoxidase) activity in a dose-dependent manner in mouse ear edema model induced by 12-O-tetradecanoylphorbol acetate (TPA), with an IC₅₀ of 0.23 μmol/ear .

HY-N7041

11-Oxomogroside IIa	EBV HSV	Infection
11-Oxomogroside IIa (11-oxomogroside II A1) is a cucurbitane glycoside extracted from the fruits of Siraitia grosVenorii. 11-Oxomogroside IIa has inhibitory effects against the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), shows weak inhibitory effects on activation of (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor .

HY-N11009

11-Oxomogroside II A1	EBV	Infection
11-Oxomogroside II A1 (compound 7) is an oxidized cucurbitin. It can be isolated from the ethanol extract of Rohanberry fruit. 11-Oxomogroside II A1 inhibits the activation of Epstein-Barr virus (EBV) early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). 11-Oxomogroside II A1 also weakly inhibits the activation of (±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor .

Cat. No.	Product Name	Type

HY-163286

BODIQPy-TPA	Dyes
BODIQPy-TPA is a lipophilic probes, which induces ferroptosis in B16 and HepG2 cells upon light irradiation through lipid peroxidation. BODIQPy-TPA reveals a maximum absorption wavelength of 488 nm and a maximum emission wavelength above 640 nm .

HY-163287

QPy-TPA	Dyes
QPy-TPA is a lipopjilc probes, which induces non-ferroptotic cell death and lipid dynamic regularion in B16 and HepG2 cells upon light irradiation. QPy-TPA reveals a maximum absorption wavelength of 400 nm and a maximum emission wavelength of 590 nm .

Cat. No.	Product Name	Type

HY-W087937

Benzamidine hydrochloride hydrate 2 Publications Verification Benzenecarboximidamide hydrochloride hydrate	Biochemical Assay Reagents
Benzamidine (Benzenecarboximidamide) hydrochloride hydrate is a reversible competitive trypsin-like serine proteases inhibitor with K_is of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively .

Cat. No.	Product Name	Target	Research Area

HY-P2333A

LCKLSL hydrochloride 3 Publications Verification	Peptides	Cardiovascular Disease
LCKLSL hydrochloride is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL hydrochloride potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL hydrochloride also inhibits the generation of plasmin and has anti-angiogenic roles .

HY-P5981

Chromozym t-PA

Biochemical Assay Reagents Others

Chromozym t-PA can be used for determination of t-PA (tissue plasminogen activator) concentration

HY-P2333

LCKLSL	Peptides	Cardiovascular Disease
LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles .

HY-P10005

D-Val-Gly-Arg-pNA	Peptides	Cardiovascular Disease
D-Val-Gly-Arg-pNA is a chromogenic substrate of TPA (tissue plasminogen activator). D-Val-Gly-Arg-pNA can be used to detect the amidolytic activity of TPA I and TPA II .

HY-114150

D-Val-Leu-Arg-pNA	Peptides	Others
D-Val-Leu-Arg-pNA is a glandular kininoreleasing enzyme substrate that also acts as a substrate for tissue-type plasminogen activator (t-PA) with no apparent affinity for fibrin .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18739

Phorbol 12-myristate 13-acetate 240+ Cited Publications PMA; tPA; Phorbol myristate acetate	Ketones, Aldehydes, Acids Croton tiglium Linn. Source classification Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields	PKC SphK NF-κB
Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator . Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells .

HY-N7691

3,29-O-Dibenzoyloxykarounidiol Karounidiol dibenzoate	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields	EBV
3,29-O-Dibenzoyloxykarounidiol (Karounidiol dibenzoate) is a triterpene benzoate isolated from the fruit of Momordica grosvenori. 3,29-O-Dibenzoyloxykarounidiol has potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induced by tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) .

HY-N7563

α-Toxicarol	Structural Classification Flavonoids Leguminosae Source classification Derris trifoliata Lour. Plants Other Flavonoids	EBV
α-Toxicarol is a potent inhibitor of EBV.α-Toxicarol significantly inhibits mouse skin tumor in vivo. α-Toxicarol inhibits the TPA-induced EBV-EA activation .

HY-N4024

Hyptadienic acid	Triterpenes Structural Classification Terpenoids Labiatae Source classification Plants Erigeron breviscapus (Vant.) Hand.-Mazz.	Others
Hyptadienic acid is a triterpene acid that can be isolated from the leaves of Perilla frutescens. Hyptadienic acid inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice with an ID₅₀ value of 0.13 mg/ear. Hyptadienic acid can be used for the research of inflammation .

HY-N11020

Cabenoside D	Triterpenes Structural Classification Caput nigri other families Terpenoids Source classification Cucurbitaceae Bryonia dioica Bojer Plants	EBV
Cabenoside D (compound 8) is a triterpenoid glycoside, which can be isolated from the methanol extract of lichen root. Cabenoside D shows anti-inflammatory activity and inhibits inflammation induced by 12-O-tetracylacyl hormone-13-acetate (TPA) in mice. Cabenoside D also inhibits TPA-induced Epstein-Barr virus (EBV) early antigen (EBV-EA) activation .

HY-N12467

24-Methylcholesterol	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Others
24-Methylcholesterol is a trans-ferulate ester that can be isolated from rice bran. 24-Methylcholesterol significantly inhibited TPA-induced inflammation .

HY-I0508

Phthalic acid 2 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Biochemical Assay Reagents
Phthalic acid is the final common metabolite of phthalic acid esters (PAEs). Phthalic acid can be used for the synthesis of synthetic agents, such as isophthalic acid (IPA), and terephthalic acid (TPA). Phthalic acid has applications in the preparation of phthalate ester plasticizers .

HY-N8873

Silychristin B	Structural Classification Glycine soya Source classification Phenols Polyphenols Plants Compositae	Others
Silychristin B is an antitumor promoter. Silychristin B inhibits TPA induced Epstein-Barr virus early antigen (EBV-EA) induction. Silychristin B can be isolated from milk thistle .

HY-N3261

Methyllinderone	Structural Classification Flavonoids Source classification Lindera erythrocarpa Makino Plants Lauraceae Other Flavonoids	AP-1 ERK STAT
Methyllinderone is an inhibitor of AP-1/STAT/ERK. Methyllinderone has anti-inflammatory effect. Methyllinderone reduce the invasion and migration rate of TPA-stimulated MCF-7 cells. Methyllinderone can be used in study breast cancer metastasis .

HY-N7040

11-Deoxymogroside IIE	Infection Triterpenes Classification of Application Fields Terpenoids Source classification Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields	HSV
11-Deoxymogroside IIE is a cucurbitane glycoside, isolated from Siraitia grosvenorii fruits. 11-Deoxymogroside IIE has inhibitory effect against Epstein Barr virus (EBV-EA) activation induced by TPA, shows weak inhibitory effect on (+/-)-(E)-methyl1-2-[E-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR1), a NO donor .

HY-N10439

3β-Acetoxy-hop-22(29)-ene	Cnidoscolus spinosus Lundell Triterpenes Terpenoids Source classification Euphorbiaceae Plants	Glucosidase
3β-Acetoxy-hop-22(29)-ene (compound 1) is a potent anti-inflammatory agent. 3β-Acetoxy-hop-22(29)-ene shows high inhibitory activity of yeast α-glucosidase, with an IC₅₀ of 5.74 μM. 3β-Acetoxy-hop-22(29)-ene inhibits MPO (myeloperoxidase) activity in a dose-dependent manner in mouse ear edema model induced by 12-O-tetradecanoylphorbol acetate (TPA), with an IC₅₀ of 0.23 μmol/ear .

HY-N7041

11-Oxomogroside IIa	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields	EBV HSV
11-Oxomogroside IIa (11-oxomogroside II A1) is a cucurbitane glycoside extracted from the fruits of Siraitia grosVenorii. 11-Oxomogroside IIa has inhibitory effects against the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), shows weak inhibitory effects on activation of (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor .

HY-N11009

11-Oxomogroside II A1	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants	EBV
11-Oxomogroside II A1 (compound 7) is an oxidized cucurbitin. It can be isolated from the ethanol extract of Rohanberry fruit. 11-Oxomogroside II A1 inhibits the activation of Epstein-Barr virus (EBV) early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). 11-Oxomogroside II A1 also weakly inhibits the activation of (±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor .

Species:	Human (3) Mouse (2)
Tag:	His (3) Tag Free (1) Fc (1)
Source:	HEK293 (4) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71051

	T-PA Protein, Human (HEK293, His) 1 Publications Verification T-PA; tPA; t-plasminogen activator; Tissue plasminogen activator;	Human	HEK293
	T-PA is a key proteolytic enzyme that coordinates the conversion of the abundant but inactive zymogen plasminogen to its active form plasmin via hydrolysis of a single Arg-Val bond. This enzymatic conversion helps regulate plasmin-mediated proteolysis, a key process in tissue remodeling, degradation, and various pathophysiological events. T-PA Protein, Human (HEK293, His) is the recombinant human-derived T-PA protein, expressed by HEK293 , with C-6*His labeled tag. The total length of T-PA Protein, Human (HEK293, His) is 527 a.a., with molecular weight of 60-75 kDa.

HY-P73451

	T-PA Protein, Human (HEK293) T-PA; tPA; t-plasminogen activator; Tissue plasminogen activator	Human	HEK293
	The T-PA protein encoded by this gene is a secreted serine protease that converts plasminogen into plasmin, a key enzyme involved in tissue remodeling and cell migration. The proteolytic process produces heavy and light chains, forming heterodimeric enzymes. T-PA Protein, Human (HEK293) is the recombinant human-derived T-PA protein, expressed by HEK293 , with tag free. The total length of T-PA Protein, Human (HEK293) is 252 a.a., with molecular weight of ~35 kDa.

HY-P73583

	T-PA Protein, Mouse (HEK293, Fc) Tissue-type plasminogen activator; t-PA; Plat	Mouse	HEK293
	The T-PA protein converts the inactive plasminogen to active plasmin by hydrolyzing a single Arg-Val bond. This conversion regulates plasmin-mediated proteolysis and is involved in tissue remodeling, degradation, and cell migration. T-PA also contributes to the prevention of polyspermy during oocyte activation by participating in the cortical granule reaction. T-PA Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived T-PA protein, expressed by HEK293 , with N-hFc labeled tag. The total length of T-PA Protein, Mouse (HEK293, Fc) is 251 a.a., with molecular weight of 55-60 kDa.

HY-P701312

	T-PA Protein, Mouse (HEK293, His) Tissue-type plasminogen activator; t-PA; Plat	Mouse	HEK293
	The T-PA protein converts the inactive plasminogen to active plasmin by hydrolyzing a single Arg-Val bond. This conversion regulates plasmin-mediated proteolysis and is involved in tissue remodeling, degradation, and cell migration. T-PA also contributes to the prevention of polyspermy during oocyte activation by participating in the cortical granule reaction. T-PA Protein, Mouse (HEK293, His) is the recombinant mouse-derived T-PA protein, expressed by HEK293 , with C-His labeled tag. The total length of T-PA Protein, Mouse (HEK293, His) is 527 a.a., with molecular weight of 13-15 kDa & 30-34 kDa & 35-40 kDa, respectively.

HY-P77508

	XTP3TPA Protein, Human (His) dCTP pyrophosphatase 1; dCtPAse 1; RS21C6; DCTPP1; CDA03	Human	E. coli
	XTP3TPA protein crucially hydrolyzes deoxynucleoside triphosphates (dNTPs), particularly preferring dCTP and its analogs, like 5-iodo-dCTP and 5-methyl-dCTP. This selective hydrolysis, reflecting high efficiency, likely safeguards against the incorporation of genotoxic nucleotide analogs into DNA or RNA, contributing to genomic integrity and protecting cellular nucleotide pools. XTP3TPA Protein, Human (His) is the recombinant human-derived XTP3TPA protein, expressed by E. coli , with N-His labeled tag. The total length of XTP3TPA Protein, Human (His) is 170 a.a., with molecular weight of ~19 kDa.

Cat. No.	Product Name	Chemical Structure

HY-I0508S

Phthalic acid-d4
Phthalic acid-d₄ is the deuterium labeled Phthalic acid. Phthalic acid is the final common metabolite of phthalic acid esters (PAEs). Phthalic acid can be used for the synthesis of synthetic agents, such as isophthalic acid (IPA), and terephthalic acid (TPA). Phthalic acid has applications in the preparation of phthalate ester plasticizers[1].

Cat. No.	Product Name	Application	Reactivity

HY-P83461

Tissue Type Plasminogen Activator Antibody (YA3206)

tPA; T-PA; tPA1; PLAT; Tissue plasminogen activator
WB, IHC-P Human, Mouse, Rat


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Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

tPA

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Natural
Products