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Results for "

thymidylate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Thymidylate Synthase (24) Antifolate (7) Apoptosis (10) Autophagy (7) Bacterial (12) Dihydrofolate reductase (DHFR) (2) DNA Methyltransferase (1) DNA/RNA Synthesis (1) EGFR (2) Endogenous Metabolite (18) HIV (5) HSV (2) Isotope-Labeled Compounds (7) Nucleoside Antimetabolite/Analog (9) Orthopoxvirus (2) Parasite (1) Tyrosinase (1)
By Research Areas:	Cancer (33) Infection (23) Inflammation/Immunology (1) Metabolic Disease (2)
Click Chemistry:	Alkynes (5)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: Thymidylate Synthase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16110

Tegafur-Uracil UFT; BMS-200604	Others	Cancer
Tegafur-Uracil is an orally active fluoropyrimidines anticancer agent. Tegafur-Uracil inhibits thymidylate synthase. Tegafur-Uracil can be used for researching anti solid tumors .

HY-13728B

(Rac)-Plevitrexed (Rac)-ZD 9331; (Rac)-BGC9331	Thymidylate Synthase	Cancer
(Rac)-Plevitrexed ((Rac)-ZD 9331; (Rac)-BGC9331)?is a racemate of Plevitrexed. Plevitrexed is an orally active and potent thymidylate synthase (TS) inhibitor. (Rac)-Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-149849

TS-IN-2	Thymidylate Synthase	Cancer
TS-IN-2 (compound 17) is a thymidylate synthase (TS) inhibitor with an IC₅₀ of 0.81 μM. TS-IN-2 induces cancer cell apoptosis and cell cycle arrest in S phase, and also inhibit DNA synthesis, resulting in DNA damage .

HY-W142014

N,O-Didansyl-L-tyrosine cyclohexylammonium	Thymidylate Synthase	Cancer
N,O-Didansyl-L-tyrosine cyclohexylammonium is a potent selective thymidylate synthase (TS) inhibitor, acts on TS of Escherichia coli, Lactobacillus casei and human with the IC₅₀ values of 5.0, 3.4 and 119 μM, respectively .

HY-143452

MtTMPK-IN-4	Tyrosinase Bacterial	Inflammation/Immunology
MtTMPK-IN-4 (compound 2), a para-piperidine, is a potent *mycobacterium tuberculosis thymidylate* kinase (MtTMPK) inhibitor with an IC₅₀ of 6.1 μM. MtTMPK-IN-4 is a potent tyrosinase** inhibitor. MtTMPK-IN-4 is a potent antibacterial agent .

HY-106168

Thymectacin NB1011	Others	Cancer
Thymectacin (NB1011) is an agent selectively targeting tumor cells that have a high expression of thymidylate synthase (TS). Thymectacin is an aryloxy phosphoramidate derivative of BVdU (brivudin) .

HY-103396

Trimetrexate glucuronate CI-898 glucuronate	Antifolate Bacterial	Infection Cancer
Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential antitumour activity and can also be used to inhibit Pneumocystis carinii pneumonia .

HY-16478

Trifluridine/tipiracil hydrochloride mixture 1 Publications Verification TAS-102; FTD/TPI	Nucleoside Antimetabolite/Analog Thymidylate Synthase	Cancer
Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA .

HY-156122

DHFR-IN-8	Dihydrofolate reductase (DHFR) Bacterial	Infection
DHFR-IN-8 (compound 6r) is a dihydrofolate reductase (DHFR) inhibitor that affects purine and thymidylate biosynthesis in cell proliferation and growth. DHFR-IN-8 inhibits methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 (IC₅₀=15.6 ng/mL) in mouse models of systemic infection and thigh infection .

HY-10822

Idetrexed BGC 945; ONX-0801	Thymidylate Synthase	Others
Idetrexed is a thymidylate synthase inhibitor specifically transported into alpha-folate receptor (alpha-FR)-overexpressing tumors. BGC 945 inhibited thymidylate synthase with a K_i of 1.2 nmol/L .

HY-146239

EGFR/HER2/TS-IN-2	EGFR Thymidylate Synthase	Cancer
EGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC₅₀ values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC₅₀ of 1.69 µM .

HY-10821

Raltitrexed 5 Publications Verification ZD1694; D1694; ICI-D1694	Thymidylate Synthase Nucleoside Antimetabolite/Analog	Cancer
Raltitrexed is an antimetabolite agent used in chemotherapy, acting by inhibiting thymidylate synthase.

HY-108474

Nolatrexed dihydrochloride 1 Publications Verification AG 337; Thymitaq	Thymidylate Synthase	Cancer
Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a K_i of 11 nM for human thymidylate synthase . Nolatrexed dihydrochloride (AG 337) induces cell cycle arrest in S phase of cancer cells. Anti-cancer activity .

HY-129125

YMU1

Others Cancer

YMU1 is a selective inhibitor of human thymidylate kinase (hTMPK) with an IC₅₀ of 610 nM .

YMU1	Others	Cancer
YMU1 is a selective inhibitor of human thymidylate kinase (hTMPK) with an IC₅₀ of 610 nM .

HY-156123

DHFR-IN-9	Dihydrofolate reductase (DHFR) Bacterial	Infection Cancer
DHFR-IN-9 (compound 8A) is a dihydrofolate reductase (DHFR) inhibitor that affects purine and thymidylate biosynthesis in cell proliferation and growth. DHFR-IN-9 inhibits methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 (IC₅₀=0.25 μg/mL) and has anti-infective effects in mouse models of systemic infection and thigh infection caused by it (dose: 2.5 mg /kg, 5 mg/kg; ip). DHFR-IN-9 has stronger anticancer activity than paclitaxel (Y-B0015) in a mouse model of breast cancer (dose: 2.5 mg/kg; ip; once every 3 days) .

HY-143207

10-Formyl-5,8-dideazafolic acid

Thymidylate Synthase Cancer

10-Formyl-5,8-dideazafolic acid is a thymidylate synthase inhibitor .

10-Formyl-5,8-dideazafolic acid	Thymidylate Synthase	Cancer
10-Formyl-5,8-dideazafolic acid is a thymidylate synthase inhibitor .

HY-10822A

ONX 0801 trisodium BGC 945 trisodium; Idetrexed trisodium; CB 300945 trisodium	Thymidylate Synthase	Cancer
ONX 0801 (BGC 945) trisodium is a thymidylate synthase (TS) inhibitor, targeted to α-folate receptor–overexpressing tumors .

HY-162155

Diarctigenin	Parasite	Infection
Diarctigenin is a selective Leishmania major dihydrofolate reductase-thymidylate synthase (LmDHFR-TS) inhibitor. Diarctigenin can be used for the research of tropical disease .

HY-D0186

2'-Deoxyuridine	Endogenous Metabolite	Infection
2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine.

HY-146700

MtTMPK-IN-6	Bacterial Thymidylate Synthase	Infection
MtTMPK-IN-6 (compound 1) is a potent M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor with an IC₅₀ value of 29 μM. MtTMPK-IN-6 can be used for researching tuberculosis .

HY-13781

Pemetrexed disodium hemipenta hydrate 15+ Cited Publications LY231514 disodium hemipenta hydrate	Antifolate Autophagy Apoptosis	Cancer
Pemetrexed disodium hemipenta hydrate is a novel antifolate, the K_i values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.

HY-10820B

Pemetrexed disodium heptahydrate 15+ Cited Publications LY231514 disodium heptahydrate	Antifolate Autophagy	Cancer
Pemetrexed disodium heptahydrate is a novel antifolate, the K_i values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.

HY-10820

Pemetrexed 15+ Cited Publications LY231514	Antifolate Autophagy	Cancer
Pemetrexed (LY231514) is an antifolate, the K_i values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively .

HY-10820A

Pemetrexed disodium 15+ Cited Publications LY231514 disodium	Antifolate Autophagy Apoptosis	Cancer
Pemetrexed disodium (LY231514 disodium) is an antifolate, the K_is of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively .

HY-W011142

2'-Deoxyuridine 5'-monophosphate disodium	Endogenous Metabolite	Metabolic Disease
2'-Deoxyuridine 5'-monophosphate disodium is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis .

HY-109115

Fosifloxuridine nafalbenamide NUC-3373	Thymidylate Synthase	Cancer
Fosifloxuridine nafalbenamide (NUC-3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. Fosifloxuridine nafalbenamide has anticancer activity. Fosifloxuridine nafalbenamide has the potential to evoke a host immune response and enhance immunoresearch .

HY-D0186S5

2'-Deoxyuridine-d	Isotope-Labeled Compounds Endogenous Metabolite	Infection
2'-Deoxyuridine-d is the deuterium labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]<

HY-D0186S4

2'-Deoxyuridine-d2	Isotope-Labeled Compounds Endogenous Metabolite	Infection
2'-Deoxyuridine-d₂ is the deuterium labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]

HY-D0186S

2'-Deoxyuridine-1′-13C	Isotope-Labeled Compounds Endogenous Metabolite	Infection
2'-Deoxyuridine-1′- ¹³C is the ¹³C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]

HY-D0186S1

2'-Deoxyuridine-2′-13C	Isotope-Labeled Compounds Endogenous Metabolite	Infection
2'-Deoxyuridine-2′- ¹³C is the ¹³C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]

HY-D0186S2

2'-Deoxyuridine-3′-13C	Isotope-Labeled Compounds Endogenous Metabolite	Infection
2'-Deoxyuridine-3′- ¹³C is the ¹³C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]

HY-D0186S3

2'-Deoxyuridine-5′-13C	Isotope-Labeled Compounds Endogenous Metabolite	Infection
2'-Deoxyuridine-5′- ¹³C is the ¹³C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]

HY-10820S

Pemetrexed-d5 LY231514-d₅	Antifolate Autophagy	Cancer
Pemetrexed-d₅ is the deuterium labeled Pemetrexed[1]. Pemetrexed (LY231514) is an antifolate, the Ki values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively[2].

HY-D0186S8

2'-Deoxyuridine-d2-1	Endogenous Metabolite	Infection
2'-Deoxyuridine-d₂-1 is the deuterium labeled 2'-Deoxyuridine[1]. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine[2].

HY-116217

5-Fluoro-2'-deoxycytidine	DNA Methyltransferase	Cancer
5-Fluoro-2'-deoxycytidine, a fluoropyrimidine nucleoside analogue, is a DNA methyltransferase (DNMT) inhibitor. 5-Fluoro-2'-deoxycytidine is a tumor-selective proagent of the potent thymidylate synthase inhibitor 5-fluoro-2′-dUMP .

HY-10820AS

Pemetrexed-d5 disodium LY231514-dd₅ disodium	Isotope-Labeled Compounds Antifolate Autophagy Apoptosis	Cancer
Pemetrexed-d₅ (disodium) is the deuterium labeled Pemetrexed disodium. Pemetrexed disodium (LY231514 disodium) is an antifolate, the Kis of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively[1].

HY-146702

MtTMPK-IN-8	Bacterial Thymidylate Synthase	Infection
MtTMPK-IN-8 (compound 27) is a moderate M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor. MtTMPK-IN-8 has sub-micromolar activity against mycobacteria (MICs = 0.78~9.4 μM) without significant cytotoxicity. MtTMPK-IN-8 can be used for researching tuberculosis .

HY-A0061

Trifluridine 1 Publications Verification Trifluorothymidine; 5-Trifluorothymidine; TFT	Thymidylate Synthase HSV Nucleoside Antimetabolite/Analog Orthopoxvirus DNA/RNA Synthesis Apoptosis Autophagy	Cancer
Trifluridine (Trifluorothymidine) is an irreversible and orally active thymidylate synthase inhibitor, and thereby suppressing DNA synthesis. Trifluridine is an antiviral molecule used for research of HSV, rhabdovirus and orthopoxvirus infection. Trifluridine induces cell apoptosis and autophagy. Trifluridine is also an anticancer agent used in studies of metastatic colorectal cancer, gastrointestinal tumors .

HY-146699

MtTMPK-IN-5	Bacterial Thymidylate Synthase	Infection
MtTMPK-IN-5 (compound 17) is a potent M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor with an IC₅₀ value of 34 μM. MtTMPK-IN-5 combines favorable enzyme inhibitory activity with significant activity against M. tuberculosis (MIC = 12.5 μM). MtTMPK-IN-5 can be used for researching tuberculosis .

HY-D0186S7

2'-Deoxyuridine-13C,15N2	Endogenous Metabolite	Infection
2'-Deoxyuridine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled 2'-Deoxyuridine[1]. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine[2].

HY-90006

5-Fluorouracil Maximum Cited Publications 176 Publications Verification 5-FU	Nucleoside Antimetabolite/Analog HIV Apoptosis Endogenous Metabolite	Cancer
5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer . 5-Fluorouracil also inhibits HIV .

HY-146703

MtTMPK-IN-9	Bacterial Thymidylate Synthase	Infection
MtTMPK-IN-9 (compound 28) is a moderate M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor with an IC₅₀ value of 48 μM. MtTMPK-IN-9 has sub-micromolar activity against mycobacteria (MICs = 6.25~9.4 μM) without significant cytotoxicity. MtTMPK-IN-9 can be used for researching tuberculosis .

HY-146701

MtTMPK-IN-7	Bacterial Thymidylate Synthase	Infection
MtTMPK-IN-7 (compound 26) is a moderate M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor with an IC₅₀ value of 47 μM. MtTMPK-IN-7 has sub-micromolar activity against mycobacteria (MICs = 2.3~4.7 μM) without significant cytotoxicity. MtTMPK-IN-7 can be used for researching tuberculosis .

HY-14520A

(6S)-Tetrahydrofolic acid (6S)-5,6,7,8-Tetrahydrofolic acid; (6S)-Tetrahydrofolic acid	Endogenous Metabolite	Metabolic Disease
(6S)-Tetrahydrofolic acid is 1000-fold more active than the (6R) form at promoting the binding of fluorodeoxyuridylate to thymidylate synthase and 600-fold more active as a growth factor of P. cerevisiae. (6S)-Tetrahydrofolic acid also has a low affinity and high dissociation rate for folate-binding protein .

HY-144663

MtTMPK-IN-1	Bacterial Thymidylate Synthase	Infection
MtTMPK-IN-1 (compound 3) is a potent Mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC₅₀ value of 2.5 μM. MtTMPK-IN-1 has moderate to weak activity against Mtb H37Rv and low cytotoxicity in human fibroblast cells MRC-5. MtTMPK-IN-1 can be used for researching tuberculosis .

HY-A0061S

Trifluridine-13C,15N2 Trifluorothymidine-¹³C,¹⁵N₂; 5-Trifluorothymidine-¹³C,¹⁵N₂; TFT-¹³C,¹⁵N₂	Thymidylate Synthase Nucleoside Antimetabolite/Analog HSV Orthopoxvirus	Cancer
Trifluridine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Trifluridine[1]. Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity[2].

HY-149352

DG1	Thymidylate Synthase	Cancer
DG1 (Compound 8Nc) is a Thymidylate Synthase (TS) inhibitor that affects cancer angiogenesis and metabolic reprogramming in NSCLC cells. DG1 can effectively inhibit the expression of CD26, ET-1, FGF-1 and EGF. DG1 also effectively inhibits the proliferation of cancer tissue in the A549 xenograft mouse model .

HY-146238

EGFR/HER2/TS-IN-1	EGFR Thymidylate Synthase Apoptosis	Cancer
EGFR/HER2/TS-IN-1 (Compound 4d) is an EGFR, HER2 and *TS (Thymidylate* synthase) inhibitor with IC₅₀ values of 0.203, 0.088 and 0.168 μM against EGFR, HER2 and TS, respectively. EGFR/HER2/TS-IN-1 induces MCF7 cell apoptosis** .

HY-13728

Plevitrexed ZD 9331; BGC9331	Thymidylate Synthase	Cancer
Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a K_i of 0.44 nM. Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical . Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-131576

Thymidine 5′-diphosphate dTDP	Endogenous Metabolite	Infection
Thymidine 5′-diphosphate (dTDP) is the key product of pyrimidine synthesis in organisms. Thymidine 5′-diphosphate is produced by thymidylate kinase (TMPK) catalyzed phosphorylation of 5′-thymidine monophosphate (dTMP), which requires ATP and Mg ²⁺. Thymidine 5′-diphosphate is further catalyzed by TMPK to thymidine 5′-triphosphate (dTTP). TMPK activity can be detected by measuring the level of Thymidine 5′-diphosphate .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-D0186

2'-Deoxyuridine	Infection Structural Classification Natural Products Microorganisms Immune System Disorder Classification of Application Fields Source classification Disease markers Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine.

HY-W011142

2'-Deoxyuridine 5'-monophosphate disodium	Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2'-Deoxyuridine 5'-monophosphate disodium is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis .

HY-90006

5-Fluorouracil 175+ Cited Publications 5-FU	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Nucleoside Antimetabolite/Analog HIV Apoptosis Endogenous Metabolite
5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer . 5-Fluorouracil also inhibits HIV .

HY-14520A

(6S)-Tetrahydrofolic acid (6S)-5,6,7,8-Tetrahydrofolic acid; (6S)-Tetrahydrofolic acid	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite
(6S)-Tetrahydrofolic acid is 1000-fold more active than the (6R) form at promoting the binding of fluorodeoxyuridylate to thymidylate synthase and 600-fold more active as a growth factor of P. cerevisiae. (6S)-Tetrahydrofolic acid also has a low affinity and high dissociation rate for folate-binding protein .

HY-131576

Thymidine 5′-diphosphate dTDP	Infection Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Thymidine 5′-diphosphate (dTDP) is the key product of pyrimidine synthesis in organisms. Thymidine 5′-diphosphate is produced by thymidylate kinase (TMPK) catalyzed phosphorylation of 5′-thymidine monophosphate (dTMP), which requires ATP and Mg ²⁺. Thymidine 5′-diphosphate is further catalyzed by TMPK to thymidine 5′-triphosphate (dTTP). TMPK activity can be detected by measuring the level of Thymidine 5′-diphosphate .

Species:	Human (1)
Tag:	His (2)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70012

	Thymidylate Protein, Human (HEK293, His) rHuthymidylate /kinaseDTYMK, His; thymidylate kinase; dTMP kinase; DTYMK; CDC8; TMPK; TYMK	Human	HEK293
	Thymidylate proteins play a key role in DNA synthesis by catalyzing the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP). This enzymatic process is critical for the production of dTDP, the direct precursor of the DNA building block dTTP. Thymidylate Protein, Human (HEK293, His) is the recombinant human-derived Thymidylate protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Thymidylate Protein, Human (HEK293, His) is 212 a.a., with molecular weight of ~26.0 kDa.

HY-P72177

	TMK Protein, Bacillus anthracis (His) tmk; BAMEG_0039thymidylate kinase; EC 2.7.4.9; dTMP kinase	Others	E. coli
	TMK proteins play a central role by catalyzing the phosphorylation of deoxythymidine monophosphate (dTMP), a key step in the synthesis of deoxythymidine triphosphate (dTTP). This process converts dTMP into deoxythymidine diphosphate (dTDP), an important intermediate in dTTP biosynthesis. TMK Protein, Bacillus anthracis (His) is the recombinant TMK protein, expressed by E. coli , with N-6*His labeled tag. The total length of TMK Protein, Bacillus anthracis (His) is 208 a.a., with molecular weight of ~25 kDa.

Cat. No.	Product Name	Chemical Structure

HY-D0186S5

2'-Deoxyuridine-d
2'-Deoxyuridine-d is the deuterium labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]<

HY-D0186S4

2'-Deoxyuridine-d2
2'-Deoxyuridine-d₂ is the deuterium labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]

HY-D0186S

2'-Deoxyuridine-1′-13C
2'-Deoxyuridine-1′- ¹³C is the ¹³C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]

HY-D0186S1

2'-Deoxyuridine-2′-13C
2'-Deoxyuridine-2′- ¹³C is the ¹³C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]

HY-D0186S2

2'-Deoxyuridine-3′-13C
2'-Deoxyuridine-3′- ¹³C is the ¹³C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]

HY-D0186S3

2'-Deoxyuridine-5′-13C
2'-Deoxyuridine-5′- ¹³C is the ¹³C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]

HY-10820S

Pemetrexed-d5
Pemetrexed-d₅ is the deuterium labeled Pemetrexed[1]. Pemetrexed (LY231514) is an antifolate, the Ki values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively[2].

HY-D0186S8

2'-Deoxyuridine-d2-1
2'-Deoxyuridine-d₂-1 is the deuterium labeled 2'-Deoxyuridine[1]. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine[2].

HY-10820AS

Pemetrexed-d5 disodium
Pemetrexed-d₅ (disodium) is the deuterium labeled Pemetrexed disodium. Pemetrexed disodium (LY231514 disodium) is an antifolate, the Kis of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively[1].

HY-D0186S7

2'-Deoxyuridine-13C,15N2
2'-Deoxyuridine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled 2'-Deoxyuridine[1]. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine[2].

HY-A0061S

Trifluridine-13C,15N2
Trifluridine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Trifluridine[1]. Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity[2].

HY-90006S

5-Fluorouracil-d1
5-Fluorouracil-d is the deuterium labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[1][2]. 5-Fluorouracil also inhibits HIV[3].

HY-90006S2

5-Fluorouracil-15N2
5-Fluorouracil- ¹⁵N₂ is the ¹⁵N-labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[1][2]. 5-Fluorouracil also inhibits HIV[3].

HY-90006S1

5-Fluorouracil-13C,15N2

5-Fluorouracil- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled 5-Fluorouracil[1]. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[2][3]. 5-Fluorouracil also inhibits HIV[4].

HY-90006S3

5-Fluorouracil-13C4,15N2

5-Fluorouracil- ¹³C₄, ¹⁵N₂ is the ¹³C and ¹⁵N labeled 5-Fluorouracil[1]. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[2][3]. 5-Fluorouracil also inhibits HIV[4].

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