tractable

By Targets:	Apoptosis (1) ROR (1) STAT (1) VDAC (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-102075B

TMP780	ROR	Inflammation/Immunology
TMP780 is an inverse agonist of RORγt with an IC₅₀ of 13 nM. RORγt is a tractable agent target for the treatment of cutaneous inflammatory disorders .

HY-128777

WEHI-9625 1 Publications Verification	VDAC Apoptosis	Cancer
WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC₅₀ of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX .

HY-P10115

APT STAT3	STAT	Cancer
APT _STAT3 is a specific STAT3-binding peptide. APT _STAT3 can bind STAT3 with high specificity and affinity (～231 nmol/L). APT _STAT3 is a tractable agent for translation to target the broad array of cancers harboring constitutively activated STAT3 .

Cat. No.	Product Name

HY-L063

Chemical Probe Library	273 compounds
Chemical probes are simply reagents with high potency, selectivity and cell-permeability which play important roles in both fundamental and applied biological research. In their most common application, chemical probes can establish the tractability of a specific target. They are used to interrogate the relationship between a target and its phenotype (biological tractability) as well as an ability to modulate that phenotype using a small molecule. Otherwise, chemical probes also have had a major impact in enabling and accelerating discoveries along the path to pioneer medicines. They have helped to improve the understanding of targets and pathways and have created opportunities for proprietary drug discovery efforts to an extent that would not have been possible otherwise. MCE provides a unique collection of 273 chemical probes with high potency (at least 100 nM potency), selectivity (at least 10-fold selectivity against any other target) and cell-permeability (at least 10 μM potency). MCE Chemical probe library is a useful tool for target identification and mechanism research.

Chemical Probe Library

273 compounds

Chemical probes are simply reagents with high potency, selectivity and cell-permeability which play important roles in both fundamental and applied biological research. In their most common application, chemical probes can establish the tractability of a specific target. They are used to interrogate the relationship between a target and its phenotype (biological tractability) as well as an ability to modulate that phenotype using a small molecule. Otherwise, chemical probes also have had a major impact in enabling and accelerating discoveries along the path to pioneer medicines. They have helped to improve the understanding of targets and pathways and have created opportunities for proprietary drug discovery efforts to an extent that would not have been possible otherwise.

MCE provides a unique collection of 273 chemical probes with high potency (at least 100 nM potency), selectivity (at least 10-fold selectivity against any other target) and cell-permeability (at least 10 μM potency). MCE Chemical probe library is a useful tool for target identification and mechanism research.

Cat. No.	Product Name	Target	Research Area

HY-P10115

APT STAT3	STAT	Cancer
APT _STAT3 is a specific STAT3-binding peptide. APT _STAT3 can bind STAT3 with high specificity and affinity (～231 nmol/L). APT _STAT3 is a tractable agent for translation to target the broad array of cancers harboring constitutively activated STAT3 .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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Screening Libraries

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