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Results for "

transferrin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Transferrin Receptor (6) Amyloid-β (1) Apoptosis (1) DNA/RNA Synthesis (2) Dynamin (1) Ferroportin (1) Lipoxygenase (1)
By Research Areas:	Cancer (5) Endocrinology (1) Inflammation/Immunology (1) Metabolic Disease (3) Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Targets Recommended: Transferrin Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3267

Transferrins	Transferrin Receptor	Others
Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Transferrins can bind to and mediate the transport of iron .

HY-P3267A

Apo-Transferrin	Ferroportin Transferrin Receptor	Others
Apo-Transferrin refers to iron free Transferrin (HY-P3267), serves as Transferrin receptor ligand and mediates iron release from endothelial cells. Apo-Transferrin indicates an iron deficient environment, can directly bind to hephaestin, which can convert Fe ²⁺ to Fe ³⁺. Apo-Transferrin mediates iron efflux most likely in cooperation with ferroportin 1 .

HY-P2297A

TfR-T12 TFA

Transferrin Receptor Metabolic Disease

TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .

TfR-T12 TFA	Transferrin Receptor	Metabolic Disease
TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .

HY-115832

Ap44mSe	Others	Cancer
Ap44mSe is a selenosemicarbazone that effectively depletes cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1. Ap44mSe forms redox active Cu complexes that target the lysosome to induce lysosomal membrane permeabilization .

HY-P2297

TfR-T12

Transferrin Receptor Metabolic Disease

TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .

TfR-T12	Transferrin Receptor	Metabolic Disease
TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .

HY-D0256A

Direct Black 38 free acid Chlorazol Black E free acid; Ferristatin II; C.I. 30235 free acid	DNA/RNA Synthesis	Inflammation/Immunology
Direct Black 38 free acid is a polysulphonated dye. Direct Black 38 free acid promotes degradation of transferrin receptor-1 in vitro and in vivo .

HY-P2314

HAIYPRH hydrochloride	Transferrin Receptor	Cancer
HAIYPRH hydrochloride, a targeting ligand, can specially bind to transferrin receptor (TfR). HAIYPRH hydrochloride can mediate the transport of nanocarriers across the blood-brain barrier .

HY-P99797

Pabinafusp alfa JR-141	Transferrin Receptor	Neurological Disease
Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice .

HY-P9999

Trontinemab RG6102; RO-7126209	Amyloid-β	Neurological Disease
Trontinemab is a bispecific and humanizedized IgG1-κ antibody, targeting to amyloid beta A4 precursor protein (APP) and transferrin receptor, p90, CD71 (TFRC). Trontinemab can be used for research on Alzheimer disease (AD) .

HY-A0060

Malotilate NKK 105	Lipoxygenase	Cancer
Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC₅₀=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes .

HY-108017

Ferric maltol	Others	Metabolic Disease
Ferric maltol is an orally active complex of a single ferric ion (Fe ³⁺). Ferric maltol has tha potential for iron deficiency anemia treatment in inflammatory bowel disease .

HY-13863

Hydroxy-Dynasore 3 Publications Verification Dyngo-4a	Dynamin	Neurological Disease
Hydroxy Dynasore (Dyngo-4a), a structural analog of Dynasore (HY-15304), is an potency improved, low cytotoxicity and non‐specific binding dynamin inhibitor with IC₅₀ values of 0.38 μM and 2.3 μM for brain dynamin I and recombinant rat dynamin II, respectively. Hydroxy Dynasore inhibits dynamin‐dependent endocytosis of transferrin with an IC₅₀ of 5.7 μM in vitro.

HY-131683

ES9-17	Others	Others
ES9-17 is an analog of ES9 (endosidin9), which is an inhibitor of clathrin heavy chain (CHC). ES9-17 is an inhibitor of clathrin-mediated endocytosis (CME), a major route for internalization of plasma membrane proteins and molecules from the extracellular environment in plants. ES9-17 inhibits the uptake of transferrin and FM4-64. ES9-17 also inhibits root growth of Arabidopsis seedings .

HY-16350

BOLD-100 NKP-1339; IT-139; KP-1339	DNA/RNA Synthesis Apoptosis	Cancer
BOLD-100 (NKP-1339; IT-139) is the first-in-class ruthenium-based anticancer agent in development against solid cancer with limited side effects. BOLD-100 induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway. BOLD-100 has a high tumor targeting potential, strongly binds to serum proteins such as albumin and transferrin and activates in the reductive tumor milieu .

Cat. No.	Product Name	Type

HY-D0256A

Direct Black 38 free acid Chlorazol Black E free acid; Ferristatin II; C.I. 30235 free acid	Dyes
Direct Black 38 free acid is a polysulphonated dye. Direct Black 38 free acid promotes degradation of transferrin receptor-1 in vitro and in vivo .

Cat. No.	Product Name	Type

HY-P3267

Transferrins

Native Proteins

Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Transferrins can bind to and mediate the transport of iron .

Transferrins	Native Proteins
Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Transferrins can bind to and mediate the transport of iron .

HY-P3267A

Apo-Transferrin	Native Proteins
Apo-Transferrin refers to iron free Transferrin (HY-P3267), serves as Transferrin receptor ligand and mediates iron release from endothelial cells. Apo-Transferrin indicates an iron deficient environment, can directly bind to hephaestin, which can convert Fe ²⁺ to Fe ³⁺. Apo-Transferrin mediates iron efflux most likely in cooperation with ferroportin 1 .

HY-150287

*Insulin-Transferrin-Selenium, 100X* ITS-G	Biochemical Assay Reagents
Insulin-Transferrin-Selenium, 100X (ITS-G) is a mixture of Insulin, transferrin, and sodium selenite that is a general supplement designed for use in classic media such as DMEM, RPMI-1640, and nutrient media such as Ham's F-12, DMEM/F-12 . Insulin-Transferrin-Seleniu is added to basal medium to reduce the amount of fetal calf serum required to culture cells.

Cat. No.	Product Name	Target	Research Area

HY-P2297A

TfR-T12 TFA

Transferrin Receptor Metabolic Disease

TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .

TfR-T12 TFA	Transferrin Receptor	Metabolic Disease
TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .

HY-P2314

HAIYPRH hydrochloride	Transferrin Receptor	Cancer
HAIYPRH hydrochloride, a targeting ligand, can specially bind to transferrin receptor (TfR). HAIYPRH hydrochloride can mediate the transport of nanocarriers across the blood-brain barrier .

HY-P2297

TfR-T12

Transferrin Receptor Metabolic Disease

TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .
HY-P5533

CRT

Peptides Cancer

CRT, an iron peptide mimic, can bind to apo-transferrin (apo-Tf). CRT can be used to modify nanoparticles, and enhances drug delivery efficiency .

TfR-T12	Transferrin Receptor	Metabolic Disease
TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .

CRT	Peptides	Cancer
CRT, an iron peptide mimic, can bind to apo-transferrin (apo-Tf). CRT can be used to modify nanoparticles, and enhances drug delivery efficiency .

Cat. No.	Product Name	Target	Research Area

HY-P99797

Pabinafusp alfa JR-141	Transferrin Receptor	Neurological Disease
Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice .

HY-P9999

Trontinemab RG6102; RO-7126209	Amyloid-β	Neurological Disease
Trontinemab is a bispecific and humanizedized IgG1-κ antibody, targeting to amyloid beta A4 precursor protein (APP) and transferrin receptor, p90, CD71 (TFRC). Trontinemab can be used for research on Alzheimer disease (AD) .

Species:	Human (3) Mouse (4) Rat (1) Pig (2)
Tag:	His (6) Fc (4)
Source:	HEK293 (10)

Cat. No.	Compare	Product Name	Species	Source

HY-P70620

	Transferrin Protein, Human (HEK293, His) Serotransferrin; transferrin; Beta-1 metal-binding globulin; Siderophilin; TF; TRF	Human	HEK293
	Transferrin proteins, iron-binding transporters, bind two Fe(3+) ions and an anion, usually bicarbonate. They transport iron from absorption and heme degradation sites to storage and utilization locations. Serum transferrin may impact cell proliferation. In microbial infection, Neisseria species utilize transferrin as an iron source, capturing and extracting iron for their metabolic needs. Transferrin Protein, Human (HEK293, His) is the recombinant human-derived Transferrin protein, expressed by HEK293 , with C-His labeled tag. The total length of Transferrin Protein, Human (HEK293, His) is 679 a.a., with molecular weight of 68-87 kDa.

HY-P78783

	Transferrin R2 Protein, Mouse (HEK293, mFc) transferrin R2; TFR2	Mouse	HEK293
	Transferrin R2 Protein is a key player in non-iron dependent cellular uptake of transferrin-bound iron, emphasizing its role in nuanced iron metabolism. Beyond this, it may crucially impact hepatocyte function and erythrocyte differentiation. The specific molecular mechanisms and regulatory impact on iron-related pathways remain to be fully elucidated, necessitating comprehensive studies to understand Transferrin R2's broader implications in cellular and physiological processes. Transferrin R2 Protein, Mouse (HEK293, mFc) is the recombinant mouse-derived Transferrin R2 protein, expressed by HEK293, with N-mFc labeled tag. The total length of Transferrin R2 Protein, Mouse (HEK293, mFc) is 696 a.a., with molecular weight of ~116 kDa.

HY-P73453

	Transferrin Protein, Mouse (HEK293, His) Serotransferrin; transferrin; Beta-1 metal-binding globulin; Siderophilin; TF; TRF	Mouse	HEK293
	Transferrin is an important iron-binding transport protein that combines two Fe(3+) ions with an anion, usually bicarbonate. Its main function is to transport iron from the site of absorption to the site of storage and utilization. Transferrin Protein, Mouse (HEK293, His) is the recombinant mouse-derived Transferrin protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Transferrin Protein, Mouse (HEK293, His) is 678 a.a., with molecular weight of approximately 85 kDa.

HY-P73454

	Transferrin Protein, Rat (HEK293, His) Serotransferrin; transferrin; Beta-1 metal-binding globulin; Siderophilin; TF; TRF	Rat	HEK293
	Transferrin is an important iron-binding transport protein that combines two Fe(3+) ions with an anion, usually bicarbonate. Its primary function is to transport iron from the site of absorption and heme degradation to the site of storage and utilization. Transferrin Protein, Rat (HEK293, His) is the recombinant rat-derived Transferrin protein, expressed by HEK293 , with C-His labeled tag. The total length of Transferrin Protein, Rat (HEK293, His) is 679 a.a., with molecular weight of ~89 kDa.

HY-P73581

	Transferrin Protein, Mouse (HEK293, Fc) Serotransferrin; transferrin; Beta-1 metal-binding globulin; Siderophilin; TF; TRF	Mouse	HEK293
	Transferrin is an important iron-binding transport protein that combines two Fe(3+) ions with an anion, usually bicarbonate. Its main function is to transport iron from the site of absorption to the site of storage and utilization. Transferrin Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Transferrin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Transferrin Protein, Mouse (HEK293, Fc) is 697 a.a., with molecular weight of ~102 kDa.

HY-P74494

	Transferrin Protein, Pig (HEK293, His) Serotransferrin; transferrin; Beta-1 metal-binding globulin; Siderophilin; TF; TRF	Pig	HEK293
	Transferrin is an important iron-binding transport protein that binds two Fe(3+) ions, usually with anions such as bicarbonate. Crucially, it transports iron from the site of absorption and heme degradation to the site of storage and utilization. Transferrin Protein, Pig (HEK293, His) is the recombinant pig-derived Transferrin protein, expressed by HEK293 , with C-His labeled tag. The total length of Transferrin Protein, Pig (HEK293, His) is 694 a.a., with molecular weight of ~80 kDa.

HY-P74495

	Transferrin Protein, Pig (HEK293, hFc) Serotransferrin; transferrin; Beta-1 metal-binding globulin; Siderophilin; TF; TRF	Pig	HEK293
	Transferrin is an important iron-binding transport protein that binds two Fe(3+) ions, usually with anions such as bicarbonate. Crucially, it transports iron from the site of absorption and heme degradation to the site of storage and utilization. Transferrin Protein, Pig (HEK293, hFc) is the recombinant pig-derived Transferrin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Transferrin Protein, Pig (HEK293, hFc) is 715 a.a., with molecular weight of 100-110 kDa.

HY-P71069

	TFRC Protein, Human (HEK293, His) transferrin receptor protein 1; TR; TfR; Trfr; T9; p90	Human	HEK293
	TFRC protein promotes cellular iron uptake through receptor-mediated endocytosis. TFRC is essential for erythroid and nervous system development and plays a crucial role in iron homeostasis. TFRC Protein, Human (HEK293, His) is the recombinant human-derived TFRC protein, expressed by HEK293 , with N-6*His labeled tag. The total length of TFRC Protein, Human (HEK293, His) is 660 a.a., with molecular weight of 78-90 kDa.

HY-P74526

	TFRC Protein, Human (HEK293, hFc) transferrin receptor protein 1; TR; TfR; Trfr; T9; p90	Human	HEK293
	TFRC protein promotes cellular iron uptake through receptor-mediated endocytosis. TFRC is essential for erythroid and nervous system development and plays a crucial role in iron homeostasis. TFRC Protein, Human (HEK293, hFc) is the recombinant human-derived TFRC protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TFRC Protein, Human (HEK293, hFc) is 672 a.a., with molecular weight of 105-115 kDa.

HY-P72455

	TFRC Protein, Mouse (HEK293, His) transferrin receptor protein 1; TR; TfR; TfR1; Trfr; CD71; Tfrc	Mouse	HEK293
	TFRC is a key protein in cellular iron uptake, coordinating receptor-mediated endocytosis of the ligand transferrin into specialized endosomes, where endosomal acidification triggers iron release. TFRC actively regulates T and B cell proliferation through iron uptake. TFRC Protein, Mouse (HEK293, His) is the recombinant mouse-derived TFRC protein, expressed by HEK293 , with N-8*His labeled tag. The total length of TFRC Protein, Mouse (HEK293, His) is 675 a.a., with molecular weight of ~90 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P81000

Transferrin Receptor 1 Antibody	WB, IHC-P, IP, FC	Human, Mouse, Rat
Transferrin Receptor 1 Antibody is an unconjugated, approximately 85 kDa, rabbit-derived, anti-Transferrin Receptor 1 monoclonal antibody. Transferrin Receptor 1 Antibody can be used for: WB, IHC-P, IP, FC expriments in human, mouse, rat background without labeling.

HY-P82100

Transferrin Receptor 2 Antibody (YA1845)

HFE3; TfR2; TFRC2
WB, IHC-P Human

HY-P80956

Transferrin Antibody (YA840) Apotransferrin; beta 1 metal binding globulin; serotransferrin; TF	WB, IHC-P, ICC/IF	Human
Transferrin Antibody (YA840) is a non-conjugated and Mouse origined monoclonal antibody about 77 kDa. It can be used for WB,IHC-P,ICC/IF assays in the background of Human.

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