trypsin-like

By Targets:	Apoptosis (1) Factor Xa (1) Fluorescent Dye (2) PROTACs (1) Proteasome (6) Ras (1) Ser/Thr Protease (6)
By Research Areas:	Cancer (7) Infection (1) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (1)

Targets Recommended: Polo-like Kinase (PLK) NOD-like Receptor (NLR) Toll-like Receptor (TLR) KLF PERK ULK METTL3 ADAMTS IGF-1R LOX-1 Nuclear Hormone Receptor 4A/NR4A FLT3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-137784

Boc-Val-Pro-Arg-AMC hydrochloride	Fluorescent Dye	Others
Boc-Val-Pro-Arg-AMC hydrochloride is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .

HY-134961

Z-Ala-Arg-Arg-AMC Fluorogenic Proteasome Substrate; Z-ARR-AMC	Proteasome	Others
Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) is a fluorogenic substrate for assaying trypsin-like activity of proteasome .

HY-137281

HMB-Val-Ser-Leu-VE	Ser/Thr Protease	Others
HMB-Val-Ser-Leu-VE is a prototype vinyl ester inhibitor. HMB-Val-Ser-Leu-VE is against trypsin-like (T-L) proteasome activity with an IC₅₀ of 0.033 μM .

HY-P4326

Boc-Val-Pro-Arg-AMC

Fluorescent Dye Others

Boc-Val-Pro-Arg-MCA is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .

Boc-Val-Pro-Arg-AMC	Fluorescent Dye	Others
Boc-Val-Pro-Arg-MCA is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .

HY-P5280

Ac-KQL-AMC	Ser/Thr Protease	Others
Ac-KQL-AMC is a fluorogenic substrate that can be used to quantify Trypsin-like activity, resulting in detectable fluorescence when cleaved by the proteasome .

HY-151611

UAMC-00050	Ser/Thr Protease	Inflammation/Immunology
UAMC-00050 is a potent trypsin-like serine protease inhibitor. UAMC-00050 can be used in research of dry eye syndrome and ocular inflammation .

HY-161177

PROTAC KRAS G12D degrader 2	PROTACs Ras	Infection
PROTAC KRAS G12D degrades SARS-CoV-2, 3-curd trypsin-like protease (3CLPro). Protac KRAS G12D degrades SARS-CoV-2, 3-curd trypsin-like protease (3CLPRO). The PROTAC molecule is designed by partially coupling a GC-376-based dipeptidyl 3CLPro ligand with pomadomide via a piperazine-piperidine linker .

HY-W018781

Benzamidine hydrochloride 2 Publications Verification	Ser/Thr Protease	Cancer
Benzamidine hydrochloride is a trypsin-like serine proteases with K_is of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively .

HY-W087937

Benzamidine hydrochloride hydrate 2 Publications Verification Benzenecarboximidamide hydrochloride hydrate	Ser/Thr Protease	Cancer
Benzamidine (Benzenecarboximidamide) hydrochloride hydrate is a reversible competitive trypsin-like serine proteases inhibitor with K_is of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively .

HY-18741

VR23	Proteasome Apoptosis	Metabolic Disease Cancer
VR23 is a small molecule that potently inhibits the activities of trypsin-like proteasomes (IC₅₀=1 nM), *chymotrypsin-like* proteasomes (IC₅₀=50-100 nM), and caspase-like proteasomes (IC₅₀**=3 μM).

HY-B0385

Gabexate mesylate 4 Publications Verification FOY	Proteasome Factor Xa	Inflammation/Immunology
Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with K_is of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with K_is of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation .

HY-10985

Marizomib Maximum Cited Publications 8 Publications Verification Salinosporamide A; NPI-0052	Proteasome	Cancer
Marizomib (Salinosporamide A) is a second-generation, irreversible, brain-penetrant, pan-proteasome inhibitor. Marizomib inhibits the CT-L (β5), CT-T-laspase-like (C-L, β1) and trypsin-like (T-L, β2) activities of the 20S proteasome (IC₅₀=3.5, 28, and 430 nM, respectively) .

HY-114015

APC-6860	Ser/Thr Protease	Cancer
APC-6860 is a trypsin-like serine proteases inhibitor with k_i values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has k_i values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer .

HY-150602

20S Proteasome activator 1	Proteasome	Neurological Disease
20S Proteasome activator 1 is a potent 20S proteasome activator with EC₂₀₀ values of 0.3 μM, 0.7 μM and 1.8 μM for trypsin-like site, chymotrypsin-like site and caspase-like site. 20S Proteasome activator 1 translates well in a cellular system, preventing the accumulation of the pathogenic A53T mutant of α-synuclein. 20S Proteasome activator 1 can be used for researching neurodegenerative diseases .

HY-112716

N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride 1 Publications Verification	Others	Cancer
N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK), a trypsin like protease inhibitor, sensitizes HeLa cells to Fas-mediated cell death.

HY-120722

TCH-165 1 Publications Verification	Proteasome	Cancer
TCH-165 is a small molecule modulator of proteasome assembly, which increases 20S levels and facilitates 20S-mediated protein degradation .

Cat. No.	Product Name	Type

HY-W087937

Benzamidine hydrochloride hydrate 2 Publications Verification Benzenecarboximidamide hydrochloride hydrate	Biochemical Assay Reagents
Benzamidine (Benzenecarboximidamide) hydrochloride hydrate is a reversible competitive trypsin-like serine proteases inhibitor with K_is of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively .

Cat. No.	Product Name	Target	Research Area

HY-134961

Z-Ala-Arg-Arg-AMC Fluorogenic Proteasome Substrate; Z-ARR-AMC	Proteasome	Others
Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) is a fluorogenic substrate for assaying trypsin-like activity of proteasome .

HY-137281

HMB-Val-Ser-Leu-VE	Ser/Thr Protease	Others
HMB-Val-Ser-Leu-VE is a prototype vinyl ester inhibitor. HMB-Val-Ser-Leu-VE is against trypsin-like (T-L) proteasome activity with an IC₅₀ of 0.033 μM .

HY-P4514

Z-Gly-Gly-Arg-βNA

Peptides Others

Z-Gly-Gly-Arg-βNA is the synthetic peptide substrate of trypsin-like activities of the proteasome .
HY-P4326

Boc-Val-Pro-Arg-AMC

Fluorescent Dye Others

Boc-Val-Pro-Arg-MCA is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .

Z-Gly-Gly-Arg-βNA	Peptides	Others
Z-Gly-Gly-Arg-βNA is the synthetic peptide substrate of trypsin-like activities of the proteasome .

Boc-Val-Pro-Arg-AMC	Fluorescent Dye	Others
Boc-Val-Pro-Arg-MCA is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .

HY-P5280

Ac-KQL-AMC	Ser/Thr Protease	Others
Ac-KQL-AMC is a fluorogenic substrate that can be used to quantify Trypsin-like activity, resulting in detectable fluorescence when cleaved by the proteasome .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-10985

Marizomib 5+ Cited Publications Salinosporamide A; NPI-0052	Marine natural products Source classification Marine microorganism	Proteasome
Marizomib (Salinosporamide A) is a second-generation, irreversible, brain-penetrant, pan-proteasome inhibitor. Marizomib inhibits the CT-L (β5), CT-T-laspase-like (C-L, β1) and trypsin-like (T-L, β2) activities of the 20S proteasome (IC₅₀=3.5, 28, and 430 nM, respectively) .

Species:	Human (4) Mouse (1)
Tag:	His (4) Tag Free (1)
Source:	HEK293 (4) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P7381

	Kallikrein-11 Protein, Human (Sf9) rHuKallikrein-11; TLSP; hK11; Hippostasin; trypsin-like protease; Serine protease 20	Human	Sf9 insect cells
	Kallikrein 11 Protein, Human (Sf9) is a possible multifunctional protease and efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin.

HY-P73263

	Kallikrein-11 Protein, Human (HEK293, His) Kallikrein-11; TLSP; hK11; Hippostasin; trypsin-like protease; Serine protease 20	Human	HEK293
	Kallikrein-11 protein is suggested to be a multifunctional protease, efficiently cleaving the substrate 'bz-Phe-Arg-4-methylcoumaryl-7-amide' and showing weak cleavage activity toward other kallikrein and trypsin substrates. It predominantly cleaves synthetic peptides after arginine residues rather than lysine residues. Kallikrein-11 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-11 protein, expressed by HEK293 , with C-His labeled tag. The total length of Kallikrein-11 Protein, Human (HEK293, His) is 232 a.a., with molecular weight of ~40 kDa.

HY-P73847

	Kallikrein-11 Protein, Mouse (HEK293, His) Kallikrein-11; TLSP; hK11; Hippostasin; trypsin-like protease; Serine protease 20	Mouse	HEK293
	Kallikrein-11 protein, a potential multifunctional protease, demonstrates efficient cleavage of the substrate 'bz-Phe-Arg-4-methylcoumaryl-7-amide,' specific to kallikrein. It also displays weaker cleavage activity toward other substrates linked to kallikrein and trypsin. This multifunctional characteristic indicates versatility in substrate recognition and cleavage, suggesting a potential role in diverse proteolytic processes. Kallikrein-11 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Kallikrein-11 protein, expressed by HEK293 , with C-His labeled tag. The total length of Kallikrein-11 Protein, Mouse (HEK293, His) is 232 a.a., with molecular weight of 35-43 kDa.

HY-P76680

	TMPRSS11D Protein, Human (HEK293, His) Transmembrane protease serine 11D; Airway trypsin-like protease; HAT	Human	HEK293
	The TMPRSS11D protein is associated with host mucosal defense and acts synergistically with substances in the airway mucosa. It critically processes ACE2, activating the human coronavirus 229E spike glycoprotein to achieve virus-cell membrane fusion. TMPRSS11D Protein, Human (HEK293, His) is the recombinant human-derived TMPRSS11D protein, expressed by HEK293 , with N-His labeled tag. The total length of TMPRSS11D Protein, Human (HEK293, His) is 232 a.a., with molecular weight of ~27.6 kDa.

HY-P70869

	TMPRSS11B Protein, Human (HEK293, His) Transmembrane Protease Serine 11B; Airway trypsin-like Protease 5; TMPRSS11B; HATL5	Human	HEK293
	TMPRSS11B, a serine protease, is susceptible to inhibition by aprotinin, leupeptin, benzamidine, SERPINA1, SPINT1, and SPINT2, highlighting its susceptibility to various regulatory mechanisms. TMPRSS11B Protein, Human (HEK293, His) is the recombinant human-derived TMPRSS11B protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TMPRSS11B Protein, Human (HEK293, His) is 378 a.a., with molecular weight of ~61.0 kDa.


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trypsin-like

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