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tryptase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Complement System (1) Factor Xa (2) Fluorescent Dye (1) Proteasome (1) Ser/Thr Protease (8) Syk (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Inflammation/Immunology (7)

14

Inhibitors & Agonists

2

Biochemical Assay Reagents

3

Peptides

8

Recombinant Proteins

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

BMS-262084	Factor Xa Ser/Thr Protease	Cardiovascular Disease
BMS-262084 is a potent, selective and irreversible inhibitor of factor XIa, with an IC₅₀ of 2.8 nM against human factor XIa. BMS-262084 also inhibits human *tryptase* (IC₅₀=5 nM). BMS-262084 exhibits antithrombotic effects .

HY-P4366

Tos-Gly-Pro-Lys-AMC

Ser/Thr Protease Others

Tos-Gly-Pro-Lys-AMC is a fluorogenic peptide substrate of tryptase .
HY-105999B

APC 366 TFA

Others Others

APC 366 (TFA) is an irreversible mast cell tryptase inhibitor. APC 366 (TFA) can be used for the research of allergic diseases .

APC 366	Ser/Thr Protease	Inflammation/Immunology
APC 366 is a selective inhibitor of mast cell *tryptase* (K_i=7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma .

Ac-Orn-Phe-Arg-AMC	Fluorescent Dye	Others
Ac-Orn-Phe-Arg-AMC is a potent fluorescent substrate of *cd–Tryptase* and β 1-Tryptase. Ac-Orn-Phe-Arg-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection .

HY-19303

CRA-2059

CRA-2059 is a highly specific and selective tryptase inhibitor, with a K_i of 620 pM for recombinant human tryptase-β (rHTβ) .

CRA-2059 hydrochloride	Ser/Thr Protease	Inflammation/Immunology
CRA-2059 hydrochloride is a highly specific and selective *tryptase* inhibitor, with a K_i of 620 pM for recombinant human tryptase-β (rHTβ) .

HY-19303B

CRA-2059 TFA

Ser/Thr Protease Inflammation/Immunology

CRA-2059 is a highly specific and selective tryptase inhibitor, with a K_i of 620 pM for recombinant human tryptase-β (rHTβ) .

Gabexate mesylate 4 Publications Verification FOY	Proteasome Factor Xa	Inflammation/Immunology
Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with K_is of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with K_is of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation .

Benzamidine hydrochloride 2 Publications Verification	Ser/Thr Protease	Cancer
Benzamidine hydrochloride is a trypsin-like serine proteases with K_is of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively .

Benzamidine hydrochloride hydrate 2 Publications Verification Benzenecarboximidamide hydrochloride hydrate	Ser/Thr Protease	Cancer
Benzamidine (Benzenecarboximidamide) hydrochloride hydrate is a reversible competitive trypsin-like serine proteases inhibitor with K_is of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively .

APC-6860	Ser/Thr Protease	Cancer
APC-6860 is a trypsin-like serine proteases inhibitor with k_i values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has k_i values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer .

FD-IN-1	Complement System	Inflammation/Immunology
FD-IN-1 (Compound 12) is an orally bioavailable and selective factor D (FD) inhibitor with an IC₅₀ of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC₅₀s of 7.7 and 6.5 µM, respectively .

R112	Syk	Inflammation/Immunology
R112 is a fast and reversible inhibitor of spleen tyrosine kinase (Syk) kinase. R112 inhibits Syk kinase activity with an IC₅₀ value of 226 nM and a Ki value of 96 nM. R112 inhibits IgE-FcεRI signaling pathway. R112 can be used for the research of allergic rhinitis .

Species:	Human (5) Mouse (2) Cynomolgus (1)
Tag:	His (8) Myc (1)
Source:	HEK293 (5) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P71125

TPSB2 Protein, Human (HEK293, His)

tryptase Beta-2; tryptase-2; tryptase II; TPSB2; TPS2
Human HEK293

	Tryptase beta-2 Protein, Mouse (HEK293, His) 1 Publications Verification tryptase beta-2; tryptase-2; Mast cell protease 6; mMCP-6	Mouse	HEK293
	Tryptase beta-2, a neutral protease abundant in mast cells, plays a key role in innate immunity. As the primary proteolytic enzyme released during mast cell activation, Tryptase beta-2 contributes significantly to immune functions. Its involvement underscores its importance in mediating cellular responses linked to innate immunity, highlighting its role in the intricate defense mechanisms of the immune system. Tryptase beta-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Tryptase beta-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Tryptase beta-2 Protein, Mouse (HEK293, His) is 255 a.a., with molecular weight of 32-38 kDa.

	TPSAB1 Protein, Human (HEK293, His) tryptase alpha/beta 1; tryptase 1; TPS1; TPS2; TPSAB1; TPSB1	Human	HEK293
	Tryptase alpha/beta 1 protein (TPSAB1) belongs to a family of trypsin-like serine proteases, and is enzymatically active and get involved in proteolysis only as heparin-stabilized tetramers, TPSAB1 is also resistant to all known endogenous proteinase inhibitors. Beta tryptase appears to be the main isoenzymes expressed in mast cells; while alpha tryptase is predominate in basophils. TPSAB1 Protein, Human (HEK293, His) is the recombinant human-derived TPSAB1 protein, expressed by HEK293, with C-6*His labeled tag. The total length of TPSAB1 Protein, Human (HEK293, His) is 245 a.a., with molecular weight of 32-37 kDa.

HY-P701050

TPSAB1 Protein, Cynomolgus (His)

tryptase alpha/beta-1; tryptase-1; tryptase I; tryptase alpha-1; TPS1; TPS2; TPSB1
Cynomolgus E. coli

	BSSP-4 Protein, Human (HEK293, His) rHuBrain-specific serine protease 4/BSSP-4, His; Brain-Specific Serine Protease 4; BSSP-4; Serine Protease 22; Serine Protease 26; tryptase Epsilon; PRSS22; BSSP4; PRSS26	Human	HEK293
	BSSP-4 Protein is notable for its specific preference in cleaving the synthetic substrate H-D-Leu-Thr-Arg-pNA over tosyl-Gly-Pro-Arg-pNA. This enzymatic selectivity indicates BSSP-4's potential modulation of specific peptide sequences, emphasizing its relevance in biological processes. BSSP-4 Protein, Human (HEK293, His) is the recombinant human-derived BSSP-4 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of BSSP-4 Protein, Human (HEK293, His) is 285 a.a., with molecular weight of 33-35 kDa.

HY-P702811

Granzyme K Protein, Human (His)

Fragmentin-3; Granzyme-3; NK-tryptase-2 (NK-Tryp-2); GZMK
Human E. coli
HY-P702812

Granzyme K Protein, Mouse (His, Myc)

Fragmentin-3; Granzyme-3; NK-tryptase-2 (NK-Tryp-2); GZMK
Mouse E. coli

	GZMA/Granzyme A Protein, Human (HEK293, His) CTL tryptase; Cytotoxic T-lymphocyte proteinase 1; Fragmentin-1; Hanukkah factor; HF; CTLA3; HFSP	Human	HEK293
	GZMA/granzyme A is enriched in cytotoxic T cells and natural killer cells and can induce caspase-independent pyroptosis after delivery to target cells. With substrate specificity for lysine or arginine residues, GZMA cleaves APEX1 and the nucleosome assembly protein SET, thereby disrupting their activity. GZMA/Granzyme A Protein, Human (HEK293, His) is the recombinant human-derived GZMA/Granzyme A protein, expressed by HEK293 , with C-His labeled tag. The total length of GZMA/Granzyme A Protein, Human (HEK293, His) is 236 a.a., with molecular weight of ~27-33 KDa.

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