type-I

By Targets:	5 alpha Reductase (5) ADAMTS (2) Adenylate Cyclase (2) AMPK (2) Androgen Receptor (1) Angiotensin Receptor (3) Antibiotic (2) Apoptosis (8) Autophagy (4) Bacterial (8) Biochemical Assay Reagents (6) Calcium Channel (3) CD20 (1) CDK (1) Cholinesterase (ChE) (1) Constitutive Androstane Receptor (1) DGK (1) DNA/RNA Synthesis (3) Endogenous Metabolite (26) Fatty Acid Synthase (FASN) (2) FLT3 (3) Fluorescent Dye (1) FXR (1) GABA Receptor (1) Glucosylceramide Synthase (GCS) (4) GlyT (2) GnRH Receptor (1) HCV (1) Histone Methyltransferase (6) IFNAR (4) Influenza Virus (2) Insulin Receptor (1) Interleukin Related (3) Isotope-Labeled Compounds (5) JAK (1) MDM-2/p53 (1) Mineralocorticoid Receptor (1) Mucin (1) nAChR (1) NO Synthase (2) Notch (1) Nucleoside Antimetabolite/Analog (38) Organoid (8) PACAP Receptor (6) Parasite (4) Phosphodiesterase (PDE) (3) Pim (1) PKA (2) PKC (2) Reactive Oxygen Species (1) SARS-CoV (1) Sodium Channel (3) STING (13) TAM Receptor (1) TGF-beta/Smad (3) TGF-β Receptor (18) Toll-like Receptor (TLR) (2) Topoisomerase (1) Trk Receptor (1) TRP Channel (1)
By Research Areas:	Cancer (91) Cardiovascular Disease (13) Endocrinology (7) Infection (12) Inflammation/Immunology (31) Metabolic Disease (25) Neurological Disease (17)
Click Chemistry:	Alkynes (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1584

Halofuginone 5+ Cited Publications RU-19110	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-E70005A

Collagenase, Type I EC 3.4.24.3	Biochemical Assay Reagents	Others
Collagenase, Type I is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type I breaks down collagens 1, 3, 7, 8, 10, gelatin, proteoglycans, aggrecan .

HY-N1584A

Halofuginone hydrobromide 5+ Cited Publications RU-19110 hydrobromide	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N1584B

Halofuginone hydrochloride RU-19110 hydrochloride	Calcium Channel DNA/RNA Synthesis Parasite Sodium Channel TGF-beta/Smad	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-153118

*Deoxyribonucleic acid sodium, from calf thymus, Type I, fibers* ctDNA sodium, type I, fibers; DNA sodium, from calf thymus, type I, fibers; Thymonucleic acid sodium, type I, fibers	Biochemical Assay Reagents	Others Cancer
Deoxyribonucleic acid sodium, from calf thymus, Type I, fibers is the sodium salts form of Calf thymus DNA (HY-109517). Calf thymus DNA is a double-stranded template DNA isolated from calf thymus. It can be used to study the interaction between DNA and DNA binding agents, as well as the structure and function of DNA, for DNA quantification and used as a substrate for DNA polymerase analysis, etc .

HY-155003

TPEQM-DMA	Fluorescent Dye	Cancer
TPEQM-DMA is a NIR-II photosensitizer. TPEQM-DMA accumulates in cancerous mitochondria, and inhibits cancer cell growth. TPEQM-DMA has potent type-I phototherapeutic efficacy to overcome the intrinsic pitfalls of PDT in combating hypoxic tumors .

HY-P1934

Cyclo(Phe-Pro) 4 Publications Verification Cyclo(phenylalanylprolyl); A-64863	HCV	Infection
Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)), a Vibrio vulnificus quorum-sensing molecule, inhibits retinoic acid-inducible gene-I (RIG-I) polyubiquitination, through its specific interaction with RIG-I, to blunt IRF-3 activation and type-I IFN production. Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) enhances susceptibility to hepatitis C virus (HCV), as well as Sendai and influenza viruses .

HY-A0104B

*HPMC (Type I,Viscosity:100mPa.s)* Hypromellose (type I,Viscosity:100mPa.s); (Hydroxypropyl)methyl cellulose (type I,Viscosity:100mPa.s); Celacol HPM 5000 (type I,Viscosity:100mPa.s)	Biochemical Assay Reagents	Others
Hypromellose (Type I,Viscosity:100mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104A

*HPMC (Type I,Viscosity:30mPa.s)* Hypromellose (type I,Viscosity:30mPa.s); (Hydroxypropyl)methyl cellulose (type I,Viscosity:30mPa.s); Celacol HPM 5000 (type I,Viscosity:30mPa.s)	Biochemical Assay Reagents	Others
Hydroxypropylmethylcellulose (Type I,Viscosity:30mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104D

*HPMC (Type I,Viscosity:4000mPa.s)* Hypromellose (type I,Viscosity:4000mPa.s); (Hydroxypropyl)methyl cellulose (type I,Viscosity:4000mPa.s); Celacol HPM 5000 (type I,Viscosity:4000mPa.s)	Biochemical Assay Reagents	Others
Hydroxypropylmethylcellulose (Type I,Viscosity:4000mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104C

*HPMC (Type I,Viscosity:400mPa.s)* Hypromellose (type I,Viscosity:400mPa.s); (Hydroxypropyl)methyl cellulose (type I,Viscosity:400mPa.s); Celacol HPM 5000 (type I,Viscosity:400mPa.s)	Biochemical Assay Reagents	Others
Hydroxypropylmethylcellulose (Type I,Viscosity:400mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-10432

A 83-01 35+ Cited Publications	Organoid TGF-β Receptor	Cancer
A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC₅₀s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively .

HY-108834

Laronidase

Others Metabolic Disease

Laronidase is an enzyme for the study of mucopolysaccharide type I disease research .
HY-U00432

S-MTC

S-Methyl-L-thiocitrulline
NO Synthase Neurological Disease

S-MTC is a selective type I nitric oxide synthase (NOS) inhibitor.
HY-136969

RU 752

Mineralocorticoid Receptor Cardiovascular Disease

RU 752 is a potent mineralocorticoid receptors (type I or MR) antagonist .

Laronidase	Others	Metabolic Disease
Laronidase is an enzyme for the study of mucopolysaccharide type I disease research .

S-MTC S-Methyl-L-thiocitrulline	NO Synthase	Neurological Disease
S-MTC is a selective type I nitric oxide synthase (NOS) inhibitor.

RU 752	Mineralocorticoid Receptor	Cardiovascular Disease
RU 752 is a potent *mineralocorticoid receptors (type I* or MR)** antagonist .

HY-W015346

Desaminotyrosine 3-(4-Hydroxyphenyl)propionic acid	Influenza Virus Endogenous Metabolite	Infection
Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.

HY-U00432A

S-MTC dihydrochloride S-Methyl-L-thiocitrulline dihydrochloride	NO Synthase	Neurological Disease
S-MTC (S-Methyl-L-thiocitrulline) dihydrochloride is a selective type I nitric oxide synthase (NOS) inhibitor.

HY-P9913

Rituximab 5+ Cited Publications Anti-Human CD20 type I, Chimeric Antibody	CD20	Inflammation/Immunology Cancer
Rituximab is an anti-CD20 chimeric monoclonal antibody used for research of certain autoimmune diseases and cancer.

HY-P4003

Adamtsostatin 16

ADAMTS Cardiovascular Disease

Adamtsostatin 16 is an anti-angiogenic 17-amino acid peptide containing type I thrombospondin motifs .

Adamtsostatin 16	ADAMTS	Cardiovascular Disease
Adamtsostatin 16 is an anti-angiogenic 17-amino acid peptide containing type I thrombospondin motifs .

HY-P2972

Arylsulfatase	Endogenous Metabolite	Others
Arylsulfatase is a type I enzyme of prokaryotes and eukaryotes. Arylsulfatase is a sulfatase enzyme, is often used in biochemical studies .

HY-12777

Asivatrep

PAC-14028
TRP Channel Inflammation/Immunology

Asivatrep (PAC-14028) is a potent and selective transient receptor potential vanilloid type I (TRPV1) antagonist.
HY-118091B

LY300503

Others Others

LY300503 is an enantiomer of LY191704. LY191704 is a human type I 5α-reductase inhibitor .
HY-P99509

Zelminemab

AMG-301
Adenylate Cyclase Neurological Disease

Zelminemab (AMG-301) is a humanized monoclonal antibody that inhibits PACAP type I (PAC1) receptor .

Asivatrep PAC-14028	TRP Channel	Inflammation/Immunology
Asivatrep (PAC-14028) is a potent and selective transient receptor potential vanilloid type I (TRPV1) antagonist.

LY300503	Others	Others
LY300503 is an enantiomer of LY191704. LY191704 is a human type I 5α-reductase inhibitor .

Zelminemab AMG-301	Adenylate Cyclase	Neurological Disease
Zelminemab (AMG-301) is a humanized monoclonal antibody that inhibits *PACAP type I* (PAC1) receptor** .

HY-12075

LY2109761 40+ Cited Publications	TGF-β Receptor Autophagy	Cancer
LY2109761 is an orally active, selective TGF-β receptor type I/II inhibitor with K_is of 38 nM and 300 nM, respectively.

HY-13226

Galunisertib 35+ Cited Publications LY2157299	TGF-β Receptor	Cancer
Galunisertib (LY2157299) is an oral and selective *TGF-β receptor type I* (TGF-βRI) kinase inhibitor with an IC₅₀** of 56 nM.

HY-132893

AZ14145845

TAM Receptor Cancer

AZ14145845 is a highly selective type I1/2 dual Mer/Axl kinase inhibitor with in vivo efficacy.

AZ14145845	TAM Receptor	Cancer
AZ14145845 is a highly selective type I1/2 dual Mer/Axl kinase inhibitor with in vivo efficacy.

HY-12071

LDN193189 45+ Cited Publications DM-3189	Organoid TGF-β Receptor	Cancer
LDN193189 is a potent selective *BMP type I* receptor (BMP I)** inhibitor. LDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC₅₀ values of 5 nM and 30 nM, respectively. LDN-193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva .

HY-113005

Glutarylcarnitine	Endogenous Metabolite	Metabolic Disease
Glutarylcarnitine is the diagnostic metabolite for malonic aciduria and glutaric aciduria type I monitored in most tandem mass spectrometry newborn screening programmes.

HY-12071B

LDN-193189 dihydrochloride 45+ Cited Publications DM-3189 dihydrochloride	TGF-β Receptor Organoid	Cancer
LDN-193189 (dihydrochloride) is a potent selective *BMP type I* receptor (BMP I)** inhibitor. LDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC₅₀ values of 5 nM and 30 nM, respectively. LDN-193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva .

HY-17020

Miglustat 3 Publications Verification N-Butyldeoxynojirimycin; NB-DNJ; OGT 918	Glucosylceramide Synthase (GCS)	Neurological Disease Inflammation/Immunology
Miglustat (N-Butyldeoxynojirimycin) is an orally active and reversible ceramide glucosyltransferase inhibitor. Miglustat can be used for the research of type I gaucher disease .

HY-13783

BIBF0775

TGF-β Receptor Cancer

BIBF0775 is a potent and selective transforming growth factor β (TGFβ) type I receptor (Alk5) inhibitor with an IC₅₀ of 34 nM.

BIBF0775	TGF-β Receptor	Cancer
BIBF0775 is a potent and selective *transforming growth factor β (TGFβ) type I* receptor (Alk5) inhibitor with an IC₅₀** of 34 nM.

HY-111634

Epsilon-momfluorothrin	Constitutive Androstane Receptor	Cancer
Epsilon-momfluorothrin is a type I synthetic pyrethroid insecticide, activates constitutive androstane receptor (CAR), and induces hepatocellular tumors in rats .

HY-17020A

Miglustat hydrochloride 3 Publications Verification N-Butyldeoxynojirimycin hydrochloride; NB-DNJ hydrochloride; OGT 918 hydrochloride	Glucosylceramide Synthase (GCS)	Neurological Disease Inflammation/Immunology
Miglustat (N-Butyldeoxynojirimycin) hydrochloride is an orally active and reversible ceramide glucosyltransferase inhibitor. Miglustat hydrochloride can be used for the research of type I gaucher disease .

HY-113005A

Glutarylcarnitine lithium	Endogenous Metabolite	Metabolic Disease
Glutarylcarnitine lithium is the diagnostic metabolite for malonic aciduria and glutaric aciduria type I monitored in most tandem mass spectrometry newborn screening programmes .

HY-113378

3-Hydroxybutyric acid 5+ Cited Publications β-Hydroxybutyric acid	Endogenous Metabolite	Metabolic Disease
3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids .

HY-W010452

3-Hydroxybutyric acid sodium 5+ Cited Publications β-Hydroxybutyric acid sodium	Endogenous Metabolite	Metabolic Disease
3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids .

HY-P3884

Arylomycin A2	Bacterial Antibiotic	Infection
Arylomycin A2, an antibiotic (Antibiotic), is a lipopeptide type I signal peptidase (SPase I) inhibitor. Arylomycin A2 has antibacterial effects .

HY-139070

D-Glyceric acid	Endogenous Metabolite	Metabolic Disease
D-Glyceric acid is an endogenous metabolite present in urine that can be used for the research of primary hyperoxaluria type I and glutaric acidemia type 2 .

HY-P99478

Bifarcept

IFNAR Inflammation/Immunology

Bifarcept is a recombinant antibody of interferon receptor type I (IFN-RI). Bifarcept can bind IFN-β and prolong its serum half-life .

Bifarcept	IFNAR	Inflammation/Immunology
Bifarcept is a recombinant antibody of interferon receptor type I (IFN-RI). Bifarcept can bind IFN-β and prolong its serum half-life .

HY-P4002

Adamtsostatin 18	ADAMTS	Cancer
Adamtsostatin 18 is an anti-angiogenic peptide derived from proteins containing type I thrombospondin motifs. Adamtsostatin 18 inhibits cell migration and proliferation .

HY-162266

C3TD879

Others Metabolic Disease

C3TD879 is a potent Type I kinase inhibitor. C3TD879 inhibits CITK catalytic activity with an IC₅₀ of 12 nM .

C3TD879	Others	Metabolic Disease
C3TD879 is a potent Type I kinase inhibitor. C3TD879 inhibits CITK catalytic activity with an IC₅₀ of 12 nM .

HY-78349

A 77-01 1 Publications Verification	TGF-β Receptor	Cancer
A 77-01 is a potent inhibitor of transforming growth factor (TGF)-β type I receptor superfamily activin-like kinase ALK5 with an IC₅₀ of 25 nM .

HY-13218

Acitazanolast WP-871	Others	Inflammation/Immunology
Acitazanolast is an orally active antiallergic agent, can inhibit histamine release. Acitazanolast can be used in study of type I anaphylaxis (immediate) caused by IgE antibodies .

HY-18623

VI 16832	Others	Cancer
VI 16832 is a broad spectrum Type I kinase inhibitor which can be used as an enrichment tool for the comparative expression analysis of protein kinases in different cancer cell lines.

HY-110363

Miglustat-d9 hydrochloride N-Butyldeoxynojirimycin-d₉ hydrochloride; NB-DNJ-d₉ hydrochloride; OGT 918-d₉ hydrochloride	Isotope-Labeled Compounds Glucosylceramide Synthase (GCS)	Neurological Disease
Miglustat-d₉ (hydrochloride) is the deuterium labeled Miglustat (hydrochloride). Miglustat hydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1)[1][2].

HY-150258

TRK-IN-22

Trk Receptor Others

TRK-IN-22 (compound 11) is a TRK inhibitor. TRK-IN-22 (compound 11), a typical type I inhibitor, covers the ATP-binding pocket of TRKA .

TRK-IN-22	Trk Receptor	Others
TRK-IN-22 (compound 11) is a TRK inhibitor. TRK-IN-22 (compound 11), a typical type I inhibitor, covers the ATP-binding pocket of TRKA .

HY-17020S

Miglustat-d9 N-Butyldeoxynojirimycin-d₉; NB-DNJ-d₉; OGT 918-d₉	Isotope-Labeled Compounds Glucosylceramide Synthase (GCS)	Neurological Disease
Miglustat-d9 is the deuterium labeled Miglustat. Miglustat (N-Butyldeoxynojirimycin) is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1) .

HY-B0199A

Mycophenolate mofetil hydrochloride RS 61443 hydrochloride; TM-MMF hydrochloride	Endogenous Metabolite Bacterial	Cancer
Mycophenolate mofetil (RS 61443) hydrochloride is a immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPD) type I/II with IC₅₀s of 39 nM and 27 nM, respectively.

HY-W008820

Glutaric acid	Endogenous Metabolite	Metabolic Disease
Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I .

HY-113005S

Glutarylcarnitine-d9 chloride	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Glutarylcarnitine-d₉ (chloride) is the deuterium labeled Glutarylcarnitine chloride. Glutarylcarnitine is the diagnostic metabolite for malonic aciduria and glutaric aciduria type I monitored in most tandem mass spectrometry newborn screening programmes.

Cat. No.	Product Name

HY-L018

TGF-beta/Smad Compound Library

223 compounds

The transforming growth factor beta (TGF-β) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD (e.g. SMAD4). R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. Deregulation of TGF-β signaling contributes to developmental defects and human diseases, including cancers, some bone diseases, chronic kidney disease, etc.

MCE designs a unique collection of 223 TGF-beta/Smad signaling pathway compounds. TGF-beta/Smad Compound Library acts as a useful tool for TGF-beta/Smad-related drug screening and disease research.

HY-L040

Anti-diabetic Compound Library

740 compounds

Diabetes mellitus, usually called diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. The most common types are Type I and Type II. Type I diabetes (T1D), also called juvenile onset diabetes mellitus or insulin-dependent diabetes mellitus, is characterized by destruction of the β-cells of the pancreas and insulin is not produced, whereas type II diabetes (T2D), also called non-insulin-dependent diabetes mellitus, is characterized by a progressive impairment of insulin secretion and relative decreased sensitivity of target tissues to the action of this hormone. Type 2 diabetes accounts for the vast majority of all diabetes mellitus. Diabetes of all types can lead to complications in many parts of the body and can increase the overall risk of dying prematurely. Possible complications include kidney failure, leg amputation, vision loss and nerve damage.

The pathogenesis of diabetes is complicated, and development of the safe and effective drugs against diabetes is full of challenge. Increasing studies have confirmed that the pathogenesis of diabetes is related to various signaling pathways, such as insulin signaling pathway, AMPK pathway, PPAR regulation and chromatin modification pathways. These signaling pathways have thus become the major source of the promising novel drug targets to treat metabolic diseases and diabetes.

MCE Anti-diabetic Compound Library owns a unique collection of 740 compounds, which mainly target SGLT, PPAR, DPP-4, AMPK, Dipeptidyl Peptidase, Glucagon Receptor, etc. This library is a useful tool for discovery anti-diabetes drugs.

Cat. No.	Product Name	Type

HY-12071G

LDN193189 (GMP) DM-3189 (GMP)	Fluorescent Dye
LDN193189 (DM-3189) (GMP) is LDN193189 (HY-12071) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. LDN193189 is selective *BMP type I* receptor** inhibitor .

Cat. No.	Product Name	Type

HY-A0104D

*HPMC (Type I,Viscosity:4000mPa.s)* Hypromellose (type I,Viscosity:4000mPa.s); (Hydroxypropyl)methyl cellulose (type I,Viscosity:4000mPa.s); Celacol HPM 5000 (type I,Viscosity:4000mPa.s)	Biochemical Assay Reagents
Hydroxypropylmethylcellulose (Type I,Viscosity:4000mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104C

*HPMC (Type I,Viscosity:400mPa.s)* Hypromellose (type I,Viscosity:400mPa.s); (Hydroxypropyl)methyl cellulose (type I,Viscosity:400mPa.s); Celacol HPM 5000 (type I,Viscosity:400mPa.s)	Biochemical Assay Reagents
Hydroxypropylmethylcellulose (Type I,Viscosity:400mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104B

*HPMC (Type I,Viscosity:100mPa.s)* Hypromellose (type I,Viscosity:100mPa.s); (Hydroxypropyl)methyl cellulose (type I,Viscosity:100mPa.s); Celacol HPM 5000 (type I,Viscosity:100mPa.s)	Biochemical Assay Reagents
Hypromellose (Type I,Viscosity:100mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104A

*HPMC (Type I,Viscosity:30mPa.s)* Hypromellose (type I,Viscosity:30mPa.s); (Hydroxypropyl)methyl cellulose (type I,Viscosity:30mPa.s); Celacol HPM 5000 (type I,Viscosity:30mPa.s)	Biochemical Assay Reagents
Hydroxypropylmethylcellulose (Type I,Viscosity:30mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P2972

Arylsulfatase

Biochemical Assay Reagents

Arylsulfatase is a type I enzyme of prokaryotes and eukaryotes. Arylsulfatase is a sulfatase enzyme, is often used in biochemical studies .
HY-E70153

Fucosyltransferase 2

EC:2.4.1.69; FUT2
Enzyme Substrates

Fucosyltransferase 2 (EC:2.4.1.69; FUT2) adds a fucose to the terminal galactose of a type I chain in an α1-2 linkage .

HY-12071G

LDN193189 (GMP) DM-3189 (GMP)	Biochemical Assay Reagents
LDN193189 (DM-3189) (GMP) is LDN193189 (HY-12071) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. LDN193189 is selective *BMP type I* receptor** inhibitor .

Cat. No.	Product Name	Target	Research Area

HY-P1934

Cyclo(Phe-Pro) 4 Publications Verification Cyclo(phenylalanylprolyl); A-64863	HCV	Infection
Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)), a Vibrio vulnificus quorum-sensing molecule, inhibits retinoic acid-inducible gene-I (RIG-I) polyubiquitination, through its specific interaction with RIG-I, to blunt IRF-3 activation and type-I IFN production. Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) enhances susceptibility to hepatitis C virus (HCV), as well as Sendai and influenza viruses .

HY-P1912

Alpha 1(I) Collagen (614-639), human

Peptides Endocrinology

Alpha 1(I) Collagen (614-639), human is a peptide fragment of alpha-1 type I collagen.
HY-P4003

Adamtsostatin 16

ADAMTS Cardiovascular Disease

Adamtsostatin 16 is an anti-angiogenic 17-amino acid peptide containing type I thrombospondin motifs .

HY-P4812

Prepro-von Willebrand factor (641-650) (bovine)	Peptides	Metabolic Disease
Prepro-von Willebrand factor (641-650) (bovine) is a fragment of Prepro-von Willebrand factor, which binds to type I collagen .

HY-P0284

C-telopeptide	Peptides	Inflammation/Immunology
C-telopeptide, a cross-linked peptide of type I collagen, is released during bone resorption and has been correlated with bone mineral density (BMD).

HY-P4016

Semastatin 5A.2

Peptides Cardiovascular Disease

Semastatin 5A.2 is an anti-angiogenic 19-amino acid peptides that are derived from proteins containing type I thrombospondin motifs .
HY-P4017

Semastatin 5A.1

Peptides Cardiovascular Disease

Semastatin 5A.1 is an anti-angiogenic 19-amino acid peptides that are derived from proteins containing type I thrombospondin motifs .

HY-P3884

Arylomycin A2	Bacterial Antibiotic	Infection
Arylomycin A2, an antibiotic (Antibiotic), is a lipopeptide type I signal peptidase (SPase I) inhibitor. Arylomycin A2 has antibacterial effects .

HY-P4002

Adamtsostatin 18	ADAMTS	Cancer
Adamtsostatin 18 is an anti-angiogenic peptide derived from proteins containing type I thrombospondin motifs. Adamtsostatin 18 inhibits cell migration and proliferation .

HY-P3974

Semastatin-5B	Peptides	Cardiovascular Disease
Semastatin-5B is an anti-angiogenic 17-amino acid peptide. Semastatin-5B can be derived from proteins containing type I thrombospondin motifs .

HY-P3674

LH-RH (7-10)	GnRH Receptor	Endocrinology
LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes .

HY-W010452S1

3-Hydroxybutyric acid-13C4 sodium β-Hydroxybutyric acid-¹³C₄ sodium	Endogenous Metabolite	Metabolic Disease
3-Hydroxybutyric acid- ¹³C₄ (sodium) is the ¹³C labeled 3-Hydroxybutyric acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium is a metabolite that is elevated in type I diabetes, and can modulate the properties of membrane lipids[1].

HY-P2508

MUC1, mucin core	Mucin	Cancer
MUC1, mucin core is the region of the MUC1 mucin core. MUC1 is a type I transmembrane glycoprotein, and is overexpressed and aberrantly glycosylated in carcinoma cells. MUC1, mucin core protein binds to domain 1 of ICAM-1 .

HY-P0220

PACAP (6-38), human, ovine, rat	PACAP Receptor	Neurological Disease
PACAP (6-38), human, ovine, rat is a potent PACAP receptor antagonist with IC₅₀s of 30, 600, and 40 nM for *PACAP type I* receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂**, respectively.

HY-P0220A

PACAP (6-38), human, ovine, rat TFA 1 Publications Verification	PACAP Receptor	Neurological Disease
PACAP (6-38), human, ovine, rat TFA is a potent PACAP receptor antagonist with IC₅₀s of 30, 600, and 40 nM for *PACAP type I* receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂**, respectively.

HY-P0221

PACAP (1-38), human, ovine, rat 3 Publications Verification Pituitary Adenylate Cyclase Activating Polypeptide 38	PACAP Receptor	Neurological Disease
PACAP (1-38), human, ovine, rat is a neuropeptide with 38 amino acid residues. PACAP (1-38) binds to *PACAP type I* receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂ with IC₅₀**s of 4 nM, 2 nM, and 1 nM, respectively.

HY-P5323

Dabcyl-AGHDAHASET-Edans	Peptides	Others
Dabcyl-AGHDAHASET-Edans is a biological active peptide. (This is a type I signal peptidase (SPase1) substrate peptide labeled with EDANS/ DABCYL FRET pair, and contains a crucial cleavage site derived from the C-terminal region of the Staphylococcus epidermidis pre-SceD protein. Abs/Em = 340/490 nm.)

HY-P1110

AF12198 1 Publications Verification	Interleukin Related	Inflammation/Immunology
AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC₅₀=8 nM) but not the human type II receptor (IC₅₀=6.7 µM) or the murine type I receptor (IC₅₀>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC₅₀=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC₅₀=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo .

HY-P0221A

PACAP (1-38), human, ovine, rat TFA Pituitary Adenylate Cyclase Activating Polypeptide 38 TFA	PACAP Receptor	Neurological Disease
PACAP (1-38), human, ovine, rat TFA is a neuropeptide with 38 amino acid residues. PACAP (1-38) binds to *PACAP type I* receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂ with IC₅₀**s of 4 nM, 2 nM, and 1 nM, respectively.

HY-P5305A

GAD65(247-266) epitope TFA	GABA Receptor	Metabolic Disease
GAD65(247-266) epitope TFA is the T cell epitopes of islet antigens，binding to I-A ^g7 (type I diabetes-associated molecule) competitively with poor affinity. GAD65 refers to Glutamic Acid Decarboxylase 65，involved in the conversion of glutamate to gamma-aminobutyric acid (GABA) .

HY-P2525

GAD65 (206-220)	Peptides	Inflammation/Immunology
GAD65 (206-220) is glutamic acid decarboxylase (GAD) 65-derived peptide, corresponding to residues 180-188. GAD65 is presented to T cells in association with I-Ag7 MHC class II molecules and a major pancreatic antigens targeted by self-reactive T cells in type I diabetes mellitus .

HY-P10153

gH625	Peptides	Others
gH625 is a cell-penetrating viral peptide which is a part of glycoprotein H of Herpes simplex virus type I. gH625 is able to cross the cell membrane and to transport many conjugated cargoes into the cytosol. gH625 is permeable to the blood-brain barrier (BBB) and can enter the rat brain in vivo without toxic effects. gH625 can be used for siRNA delivery research .

HY-P5472

Tumour-associated MUC1 epitope	Peptides	Others
Tumour-associated MUC1 epitope is a biological active peptide. (This sequence is the hallmark of MUC1 mucin. MUC1 is a highly glycosylated type I transmembrane glycoprotein with a unique extracellular domain consisting of a variable number of tandem repeats (VNTR) of this 20 amino acid peptide. It is overexpressed on the cell surface of many human adenocarcinomas and hematological malignancies, including multiple myeloma and B-cell lymphoma, making MUC1 broadly applicable target for immunotherapeutic strategies.)

HY-13948

Angiotensin II human Maximum Cited Publications 93 Publications Verification Angiotensin II; Ang II; DRVYIHPF	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

HY-13948A

Angiotensin II human acetate Maximum Cited Publications 93 Publications Verification Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

HY-13948B

Angiotensin II human TFA Maximum Cited Publications 93 Publications Verification Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Angiotensin II human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

Cat. No.	Product Name	Target	Research Area

HY-P99168

Anifrolumab	Inhibitory Antibodies	Inflammation/Immunology
Anifrolumab is a type I interferon (IFN) receptor antagonist, a human monoclonal antibody. Anifrolumab blocks the activity of type I interferon. Anifrolumab can be used in systemic lupus erythematosus (SLE) research .

HY-P9913

Rituximab 5+ Cited Publications Anti-Human CD20 type I, Chimeric Antibody	CD20	Inflammation/Immunology Cancer
Rituximab is an anti-CD20 chimeric monoclonal antibody used for research of certain autoimmune diseases and cancer.

HY-P99509

Zelminemab

AMG-301
Adenylate Cyclase Neurological Disease

Zelminemab (AMG-301) is a humanized monoclonal antibody that inhibits PACAP type I (PAC1) receptor .

HY-P990251

*Anti-Human/Mouse denatured collagen type-I* Antibody (XL313)**	Inhibitory Antibodies	Others
Anti-Human/Mouse denatured collagen type-I Antibody (XL313) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to human/mouse denatured collagen type-I.

HY-P99478

Bifarcept

IFNAR Inflammation/Immunology

Bifarcept is a recombinant antibody of interferon receptor type I (IFN-RI). Bifarcept can bind IFN-β and prolong its serum half-life .

HY-P99530

Valanafusp alfa AGT-181; HIRMAb-IDUA	Insulin Receptor	Metabolic Disease
Valanafusp alfa (AGT-181) is a brain penetrating recombinant fusion protein of a chimeric monoclonal antibody against the human insulin receptor (HIR) and human iduronidase (IDUA). Valanafusp alfa can be used for the research of Mucopolysaccharidosis type I (MPS I) .

HY-P99694

Lepunafusp alfa JR-171	Inhibitory Antibodies	Neurological Disease
Lepunafusp alfa (JR-171) is a BBB-penetrable fusion protein consisting of J-Brain Cargo and IDUA (a lysosomal enzyme, α-L-iduronidase). Lepunafusp alfa can reduce concentration of heparan sulfate (HS) and dermatan sulfate (DS). Lepunafusp alfa can be used for research of mucopolysaccharidosis type I .

HY-P99008

Atibuclimab 1 Publications Verification	Inhibitory Antibodies	Inflammation/Immunology
Atibuclimab, is a chimeric monoclonal antibody directed against CD14 and is composed of murine variable and human IgG4 Fc regions. Atibuclimab can be used for the research of amyotrophic lateral sclerosis . Atibuclimab attenuates LPS-induced symptoms and strongly inhibits LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist .

HY-P99171

Gevokizumab	Interleukin Related	Inflammation/Immunology
Gevokizumab is a potent anti-IL-1β antibody, negatively modulates IL-1β signaling through an allosteric mechanism. Gevokizumab selectively decreases the binding affinity of IL-1β for the IL-1 receptor type I (IL-1RI) signaling receptor instead of IL-1 counter-regulatory decoy receptor (IL-1 receptor type II) .

HY-P99666

Interferon alfa	IFNAR	Infection
Albinterferon alfa-2b is a type I interferon that activates novel genes and exerts potent antiviral and antiproliferative activity on target cells. Signaling by Albinterferon alfa-2b requires receptor-dependent activation of Stat1 and Stat2 to form a heterodimeric STAT that binds to the DNA-binding protein IRF-9 (p48) and forms ISGF-3 (IFN-stimulated gene factor 3). The driver genes are then further activated by ISGF-3 to achieve antiviral function .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1584

Halofuginone 5+ Cited Publications RU-19110	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Dichroa febrifuga Lour Source classification Saxifragaceae Plants Inflammation/Immunology Disease Research Fields	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N1584A

Halofuginone hydrobromide 5+ Cited Publications RU-19110 hydrobromide	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Dichroa febrifuga Lour Source classification Saxifragaceae Plants Inflammation/Immunology Disease Research Fields	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-W015346

Desaminotyrosine 3-(4-Hydroxyphenyl)propionic acid	Infection Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Disease Research Fields	Influenza Virus Endogenous Metabolite
Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.

HY-113005

Glutarylcarnitine	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Glutarylcarnitine is the diagnostic metabolite for malonic aciduria and glutaric aciduria type I monitored in most tandem mass spectrometry newborn screening programmes.

HY-113005A

Glutarylcarnitine lithium	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Glutarylcarnitine lithium is the diagnostic metabolite for malonic aciduria and glutaric aciduria type I monitored in most tandem mass spectrometry newborn screening programmes .

HY-113378

3-Hydroxybutyric acid 5+ Cited Publications β-Hydroxybutyric acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids .

HY-W010452

3-Hydroxybutyric acid sodium 5+ Cited Publications β-Hydroxybutyric acid sodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids .

HY-139070

D-Glyceric acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
D-Glyceric acid is an endogenous metabolite present in urine that can be used for the research of primary hyperoxaluria type I and glutaric acidemia type 2 .

HY-B0199A

Mycophenolate mofetil hydrochloride RS 61443 hydrochloride; TM-MMF hydrochloride	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Bacterial
Mycophenolate mofetil (RS 61443) hydrochloride is a immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPD) type I/II with IC₅₀s of 39 nM and 27 nM, respectively.

HY-W008820

Glutaric acid	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Metabolic Disease Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I .

HY-127167

3',4'-Dihydroxyflavone	Structural Classification Flavonoids Flavones Labiatae Source classification Plants Pluchea indica (L.) Less.	Others
3',4'-Dihydroxyflavone is a flavonoid. 3',4'-Dihydroxyflavone has antiallergic activity with an IC₅₀ value of 30 μM. 3',4'-Dihydroxyflavone can be used for the research of type I allergy .

HY-N12653

Exserohilone (-)-Exserohilone	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Reactive Oxygen Species
Exserohilone ((-)-Exserohilone) is a thiodiketopiperazine derivative that exhibits the inhibition of TNF-α-induced ROS generation and MMP-1 secretion. Exserohilone increases the procollagen type I α1 secretion in human dermal fibroblasts .

HY-110385

cGAMP disodium 5+ Cited Publications Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Endogenous Metabolite
cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-110385A

cGAMP diammonium 5+ Cited Publications Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium	Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology	STING Endogenous Metabolite
cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-N0331

Ziyuglycoside I	Triterpenes Structural Classification Classification of Application Fields Sanguisorba officinalis Linn. Terpenoids Source classification Rosaceae Plants Disease Research Fields Cancer	MDM-2/p53 Apoptosis
Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics . Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential agent candidate for treating triple-negative breast cancer (TNBC) .

HY-15371

Forskolin Maximum Cited Publications 94 Publications Verification Coleonol; Colforsin; HL 362	Structural Classification Classification of Application Fields Terpenoids Labiatae Source classification Metabolic Disease Diterpenoids Plants Inflammation/Immunology Disease Research Fields Endocrinology Gochnatia polymorpha (Less) Cabr.	Organoid Adenylate Cyclase FXR Autophagy PKC
Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀ of 0.5 μM for type I adenylyl cyclase . Forskolin is also an inducer of intracellular cAMP formation . Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR . Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy .

HY-N10661

Ipomoeassin F Ipom-F	Structural Classification Natural Products Ipomoea squamosa Choisy Plants Convolvulaceae	SARS-CoV
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .

HY-12326A

c-di-AMP disodium 2 Publications Verification Cyclic diadenylate disodium; Cyclic-di-AMP disodium	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Bacterial Endogenous Metabolite
c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-12326B

c-di-AMP diammonium 2 Publications Verification Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Bacterial Endogenous Metabolite
c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-12326

c-di-AMP Cyclic diadenylate; Cyclic-di-AMP	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Bacterial Endogenous Metabolite
c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-N2038

3,5,6,7,8,3',4'-Heptemthoxyflavone	Structural Classification Flavonols Flavonoids Rutaceae Plants Citrus reticulata Blanco	Phosphodiesterase (PDE)
3,5,6,7,8,3',4'-Heptemthoxyflavone, a flavonoid from satsuma peel, is an orally available CREB activator with anti-tumor and anti-neuroinflammatory activity. 3,5,6,7,8,3',4'-Heptemthoxyflavone inhibits collagenase activity and increases the content of type I procollagen in human dermal fibroblast neoblast (HDFn) cells. 3,5,6,7,8,3',4'-Heptemthoxyflavone induces brain-derived neurotrophic factor (BDNF) expression through the cAMP/ERK/CREB signaling pathway and reduces phosphodiesterase activity in C6 glioma .

HY-12326R

c-di-AMP (Standard) Cyclic diadenylate (Standard); Cyclic-di-AMP (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	STING Bacterial Endogenous Metabolite
c-di-AMP (Standard) is the analytical standard of c-di-AMP. This product is intended for research and analytical applications. c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-13948

Angiotensin II human 90+ Cited Publications Angiotensin II; Ang II; DRVYIHPF	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Cancer	Angiotensin Receptor Apoptosis
Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

Species:	Human (21) Mouse (3) Rat (1)
Tag:	SUMO (2) His (20) Tag Free (3) Strep (1) Myc (1) Fc (2)
Source:	HEK293 (8) E. coli Cell-free (1) P. pastoris (2) Sf9 insect cells (3) E. coli (11)

Cat. No.	Compare	Product Name	Species	Source

HY-P700090AF

	Animal-Free IFN-beta Protein, Human (His) IFNB1; type I Interferon	Human	E. coli
	PDGF R beta protein is a receptor protein that binds to platelet-derived growth factor (PDGF). It is expressed in a variety of cells, including fibroblasts and smooth muscle cells. Animal-Free IFN-beta Protein, Human (His) is the recombinant human-derived animal-FreeIFN-beta protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IFN-beta Protein, Human (His) is 166 a.a., with molecular weight of ~20.84 kDa.

HY-P700183AF

	Animal-Free IFN alpha 1a Protein, Mouse (His) Leukocyte Interferon; IFNA2; B cell Interferon; type I Interferon	Mouse	E. coli
	IFN alpha 1a Protein, synthesized by macrophages, exhibits robust antiviral activities by stimulating key enzymes—a protein kinase and an oligoadenylate synthetase. This orchestrated molecular response enhances the host's immune defenses against viral threats. Animal-Free IFN alpha 1a Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIFN alpha 1a protein, expressed by E. coli, with N-His labeled tag. The total length of Animal-Free IFN alpha 1a Protein, Mouse (His) is 166 a.a., with molecular weight of ~19.93 kDa.

HY-P71618

	KRT35 Protein, Human (His-SUMO) Hair keratin; Hair keratin; type I Ha5; HHA5; HKA5; K35; Keratin; Keratin; type I cuticular Ha5; Keratin-35; KRT35; KRTHA5; type I cuticular Ha5; type I Ha5	Human	E. coli
	KRT35 Protein shows early expression in the hair follicle, primarily localized in supramatricial and lowermost cortical cells of the hair bulb. KRT35 Protein, Human (His-SUMO) is the recombinant human-derived KRT35 protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of KRT35 Protein, Human (His-SUMO) is 455 a.a., with molecular weight of ~66.4 kDa.

HY-P70834

	INPP5A Protein, Human (HEK293, His) type I inositol 1; 4; 5-trisphosphate 5-phosphatase; INPP5A	Human	HEK293
	INPP5A Protein, a phosphatase, catalyzes the hydrolysis of inositol phosphates, converting inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate. This enzymatic action underscores its role in inositol phosphate metabolism. INPP5A is crucial for the survival of cerebellar Purkinje cells, emphasizing its significance in cellular processes and neuronal function. INPP5A Protein, Human (HEK293, His) is the recombinant human-derived INPP5A protein, expressed by HEK293 , with C-6*His labeled tag. The total length of INPP5A Protein, Human (HEK293, His) is 410 a.a., with molecular weight of ~48.0 kDa.

HY-P74624

	Podoplanin Protein, Rat (HEK293, hFc) Podoplanin; T1-alpha; T1A; type I cell 40 kDa protein; PDPN	Rat	HEK293
	The Podoplanin protein coordinates migration and adhesion by interacting with partners such as CLEC1B and CD9. It aids in blood vessel separation, platelet activation and platelet aggregation. Podoplanin Protein, Rat (HEK293, hFc) is the recombinant rat-derived Podoplanin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Podoplanin Protein, Rat (HEK293, hFc) is 113 a.a., with molecular weight of ~38.6 kDa.

HY-P71833

	Arginase-1/ARG1 Protein, Mouse (P.pastoris, His) Arg1Arginase-1; EC 3.5.3.1; Liver-type arginase; type I arginase	Mouse	P. pastoris
	Arginase-1 (ARG1) plays a key role in the urea cycle, converting L-arginine into urea and L-ornithine. This cycle maintains L-arginine homeostasis, which is critical for nitric oxide synthase to compete for arginine. Arginase-1/ARG1 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Arginase-1/ARG1 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Arginase-1/ARG1 Protein, Mouse (P.pastoris, His) is 323 a.a., with molecular weight of ~36.8 kDa.

HY-P701885

	FNTA Protein, Human FNTA; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; CAAX farnesyltransferase subunit alpha; FTase-alpha; Ras proteins prenyltransferase subunit alpha; type I protein geranyl-geranyltransferase subunit alpha; GGTase-I-alpha	Human	E. coli
	FNTA protein is a key subunit in the farnesyltransferase and geranylgeranyltransferase complexes, which can transfer farnesyl or geranylgeranyl moieties to proteins with Cys-aliphatic-aliphatic-X sequence cysteine residues in proteins. This enzymatic activity contributes to post-translational protein modifications. FNTA Protein, Human is the recombinant human-derived FNTA protein, expressed by E. coli , with tag free. The total length of FNTA Protein, Human is 379 a.a., .

HY-P701886

	FNTA Protein, Human (His, Strep) FNTA; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; CAAX farnesyltransferase subunit alpha; FTase-alpha; Ras proteins prenyltransferase subunit alpha; type I protein geranyl-geranyltransferase subunit alpha; GGTase-I-alpha	Human	E. coli
	FNTA protein is a key subunit in the farnesyltransferase and geranylgeranyltransferase complexes, which can transfer farnesyl or geranylgeranyl moieties to proteins with Cys-aliphatic-aliphatic-X sequence cysteine residues in proteins. This enzymatic activity contributes to post-translational protein modifications. FNTA Protein, Human (His, Strep) is the recombinant human-derived FNTA protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of FNTA Protein, Human (His, Strep) is 379 a.a., .

HY-P700089AF

	Animal-Free IFN-alpha 1a/IFNA1 Protein, Human (His) Leukocyte Interferon; IFNA1; B cell Interferon; type I Interferon; Interferon alpha-1/13; IFN-alpha-1/13; LeIF D; IFNA1a; IFNA13	Human	E. coli
	IFN-alpha 1a/IFNA1 Protein, produced by macrophages, demonstrates robust antiviral activities. It stimulates essential enzymes—a protein kinase and an oligoadenylate synthetase—contributing to the intricate molecular response that fortifies the host's immune defenses against viral threats. Animal-Free IFN-alpha 1a/IFNA1 Protein, Human (His) is the recombinant human-derived animal-FreeIFN-alpha 1a/IFNA1 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free IFN-alpha 1a/IFNA1 Protein, Human (His) is 166 a.a., with molecular weight of ~20.19 kDa.

HY-P701881

	FASN Protein, Human (Sf9) FASN; Fatty acid synthase; type I fatty acid synthase; [Acyl-carrier-protein] S-acetyltransferase; [Acyl-carrier-protein] S-malonyltransferase; 3-oxoacyl-[acyl-carrier-protein] synthase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Enoyl-[acyl-carrier-protein] reductase; Acyl-[acyl-carrier-protein] hydrolase	Human	Sf9 insect cells
	FASN (fatty acid synthase) is a multifunctional enzyme that is key to the de novo biosynthesis of long-chain saturated fatty acids from acetyl-CoA and malonyl-CoA using NADPH. This multifunctional protein contains seven catalytic activities and has an acyl carrier protein (ACP) domain with a binding site for the prosthetic group 4'-phosphopantetheine. FASN Protein, Human (Sf9) is the recombinant human-derived FASN protein, expressed by Sf9 insect cells , with tag free. The total length of FASN Protein, Human (Sf9) is 416 a.a., .

HY-P701882

	FASN Protein, Human (Sf9, His) FASN; Fatty acid synthase; type I fatty acid synthase; [Acyl-carrier-protein] S-acetyltransferase; [Acyl-carrier-protein] S-malonyltransferase; 3-oxoacyl-[acyl-carrier-protein] synthase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Enoyl-[acyl-carrier-protein] reductase; Acyl-[acyl-carrier-protein] hydrolase	Human	Sf9 insect cells
	FASN (fatty acid synthase) is a multifunctional enzyme that is key to the de novo biosynthesis of long-chain saturated fatty acids from acetyl-CoA and malonyl-CoA using NADPH. This multifunctional protein contains seven catalytic activities and has an acyl carrier protein (ACP) domain with a binding site for the prosthetic group 4'-phosphopantetheine. FASN Protein, Human (Sf9, His) is the recombinant human-derived FASN protein, expressed by Sf9 insect cells , with N-8*His labeled tag. The total length of FASN Protein, Human (Sf9, His) is 416 a.a., .

HY-P70483

	IFNAR1 Protein, Human (HEK293, His) Interferon Alpha/Beta Receptor 1; IFN-R-1; IFN-Alpha/Beta Receptor 1; Cytokine Receptor Class-II Member 1; Cytokine Receptor Family 2 Member 1; CRF2-1; type I Interferon Receptor 1; IFNAR1; IFNAR	Human	HEK293
	IFNAR1, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFNAR1 forms the heterodimeric receptor with IFNAR2. IFNAR1 mediates IFN-induced STAT signaling by interacting with tyrosine kinase 2 (Tyk2). Upon activation by these IFNs, IFNAR1 and IFNAR2 undergo a conformational change to promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2. IFNAR1 Protein, Human (HEK293, His) is a recombinant human IFNAR1 (K28-K436) with C-terminal 6*His tag, which is produced in HEK293 cells.

HY-P7411

	TGF alpha/TGFA Protein, Human rHuTGF-α; ETGF; TGF-type I	Human	E. coli
	TGF-alpha Protein, Human is a 50-amino-acid polypeptide that binds to the epidermal growth factor (EGF) receptor and stimulates cell growth.

HY-P77120

	ADCYAP1R1 Protein, Human (HEK293, Fc) Pituitary adenylate cyclase-activating polypeptide type I receptor; PACAP-R1; ADCYAP1R1	Human	HEK293
	The ADCYAP1R1 protein is a receptor for pituitary adenylate cyclase-activating polypeptide (PACAP) and recognizes PACAP-27 and PACAP-38. Through the G protein, this receptor activates adenylyl cyclase, initiating multiple downstream signaling pathways. ADCYAP1R1 Protein, Human (HEK293, Fc) is the recombinant human-derived ADCYAP1R1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ADCYAP1R1 Protein, Human (HEK293, Fc) is 155 a.a., with molecular weight of ~65 kDa.

HY-P700580

	HK1/Hexokinase-1 Protein, Human (463a.a, His) Hexokinase-1; HK1; Brain form hexokinase; Hexokinase type I; HK I; Hexokinase-A	Human	E. coli
	The HK1/hexokinase-1 protein phosphorylates hexose sugars, including D-glucose, D-glucosamine, D-fructose, D-mannose, and 2-deoxy-D-glucose, to form the corresponding hexose 6-phosphate. HK1/Hexokinase-1 Protein, Human (463a.a, His) is the recombinant human-derived HK1/Hexokinase-1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HK1/Hexokinase-1 Protein, Human (463a.a, His) is 463 a.a., with molecular weight of 55.9 kDa.

HY-P700581

	HK1/Hexokinase-1 Protein, Human (463a.a, P. pastoris, His) Hexokinase-1; HK1; Brain form hexokinase; Hexokinase type I; HK I; Hexokinase-A	Human	P. pastoris
	The HK1/hexokinase-1 protein phosphorylates hexose sugars, including D-glucose, D-glucosamine, D-fructose, D-mannose, and 2-deoxy-D-glucose, to form the corresponding hexose 6-phosphate. HK1/Hexokinase-1 Protein, Human (463a.a, P. pastoris, His) is the recombinant human-derived HK1/Hexokinase-1 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of HK1/Hexokinase-1 Protein, Human (463a.a, P. pastoris, His) is 463 a.a., with molecular weight of 53.9 kDa.

HY-P78044

	THSD7A Protein, Human (HEK293, His) Thrombospondin type-1 domain-containing protein 7A; Gm837; KIAA0960; thrombospondin,type I,domain containing 7A	Human	HEK293
	THSD7A Protein orchestrates actin cytoskeleton rearrangement, actively influencing cellular dynamics. Its soluble form facilitates endothelial cell migration and filopodia formation in sprouting angiogenesis, relying on Focal Adhesion Kinase (FAK) activation. This emphasizes THSD7A's role in modulating key cellular processes associated with angiogenesis, highlighting its potential as a regulator of vascular development. THSD7A Protein, Human (HEK293, His) is the recombinant human-derived THSD7A protein, expressed by HEK293 , with C-His labeled tag. The total length of THSD7A Protein, Human (HEK293, His) is 1560 a.a., with molecular weight of 180-240 kDa.

HY-P7604

	AKR1C3 Protein, Human (HEK293, His) rHuAKR1C3, His; AKR1C3; HA1753; Dihydrodiol Dehydrogenase type I; Indanol Dehydrogenase; Prostaglandin F Synthase	Human	HEK293
	AKR1C3 Protein, Human (HEK293, His) expresses in HEK293 cells with a His tag. Aldo-keto reductase family 1 member C3 (AKR1C3) is a steroidogenic enzyme that plays a crucial role in the conversion of adrenal androgen dehydroepiandrosterone (DHEA) into high-affinity ligands for the androgen receptor (testosterone [T] and dihydrotestosterone [DHT]).

HY-P75982

	PRKAR1A Protein, Mouse (sf9, His) cAMP-dependent protein kinase type I-alpha regulatory subunit; Tissue-specific extinguisher 1; TSE1; PKR1; PRKAR1	Mouse	Sf9 insect cells
	PRKAR1A protein is a regulatory subunit of cAMP-dependent protein kinase that mediates cellular responses to cAMP signaling. The inactive holoenzyme has two regulatory chains and two catalytic chains. PRKAR1A Protein, Mouse (sf9, His) is the recombinant mouse-derived PRKAR1A protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of PRKAR1A Protein, Mouse (sf9, His) is 381 a.a., with molecular weight of ~44.6 kDa.

HY-P70066

	*CDO1/Cysteine dioxygenase type* 1 Protein, Human (His)** 1 Publications Verification rHuCysteine dioxygenase type 1/CDO1, His; Cysteine Dioxygenase type 1; Cysteine Dioxygenase type I; CDO; CDO-I; CDO1	Human	E. coli
	Cysteine dioxygenase (CDO1) plays a crucial role in cellular metabolism by catalyzing the oxidation of cysteine to cysteine sulfenic acid, a key step involving the addition of molecular dioxygen . This enzymatic process underlies cysteine catabolism and helps regulate sulfur amino acid metabolism. CDO1/Cysteine dioxygenase type 1 Protein, Human (His) is the recombinant human-derived CDO1/Cysteine dioxygenase type 1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CDO1/Cysteine dioxygenase type 1 Protein, Human (His) is 200 a.a., with molecular weight of 20-28 kDa.

HY-P71668

	KRT18 Protein, Human (HEK293, His) Cell proliferation inducing gene 46 protein; Cell proliferation inducing protein 46 ; Keratin D ; keratin, type I cytoskeletal 18; Keratin-18; Krt18	Human	HEK293
	The KRT18 protein is a heterotetramer with KRT8 that has multiple roles, including uptake of thrombin-antithrombin complexes and assisting in the delivery of mutated CFTR to the plasma membrane. It cooperates with KRT8 in IL-6-mediated barrier protection and interacts with PLEC isoform 1C. KRT18 Protein, Human (HEK293, His) is the recombinant human-derived KRT18 protein, expressed by HEK293 , with N-10*His labeled tag. The total length of KRT18 Protein, Human (HEK293, His) is 429 a.a., with molecular weight of ~50.8 kDa.

HY-P71244

	PTH1R Protein, Human (HEK293, His) Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHrP type I receptor; PTH/PTHr receptor; Parathyroid hormone 1 receptor; PTH1 receptor; PTH1R	Human	HEK293
	PTH1R Protein, Human (HEK 293, His) is a recombinant PTH1R protein with a His-Flag. PTH1R plays an important role in skeletal development and homeostasis.

HY-P70801

	TNFRSF1A Protein, Human (His) Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; TNFAR; TNFR1	Human	E. coli
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNFRSF1A Protein, Human (His) is expressed by E. coli and has a transmembrane region (I22-T211) with a 6*His tag at the N-terminus.

HY-P702336

	IL1R1 Protein, Human (Cell-Free, His, SUMO, Myc) Interleukin-1 receptor type 1; CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha; Interleukin-1 receptor type I; p80	Human	E. coli Cell-free
	IL1R1 protein is the receptor for IL1A, IL1B and IL1RN and forms a high-affinity complex with IL1RAP upon ligand binding. This complex activates NF-kappa-B, MAPK and other pathways, recruiting adapter molecules such as TOLLIP, MYD88 and IRAK1 or IRAK2. IL1R1 Protein, Human (Cell-Free, His, SUMO, Myc) is the recombinant human-derived IL1R1 protein, expressed by E. coli Cell-free , with N-10*His, C-Myc, N-SUMO labeled tag. The total length of IL1R1 Protein, Human (Cell-Free, His, SUMO, Myc) is 552 a.a., with molecular weight of 83.5 kDa.

HY-P71565

	FCRL6 Protein, Human (His) Fc receptor homolog 6; Fc receptor-like 6; Fc receptor-like protein 6; Fc receptor-like protein 7; FcR-like protein 6; FcRH6; FcRL6; FCRL6_HUMAN; FLJ16056; IFGP6; IgSF type I transmembrane receptor; leukocyte receptor	Human	E. coli
	FCRL6 Protein serves as a receptor for MHC class II, interacting with HLA-DR when specific beta chains are associated. Although independent stimulation of FCRL6 doesn't contribute to cytokine production or cytotoxic activities, it exhibits tyrosine-phosphorylated interactions with proteins like PTPN11, PTPN6, INPP5D, INPPL1, and GRB2. These associations suggest FCRL6's potential regulatory role in signaling pathways involving tyrosine phosphorylation events with various cellular proteins. FCRL6 Protein, Human (His) is the recombinant human-derived FCRL6 protein, expressed by E. coli, with N-His labeled tag. The total length of FCRL6 Protein, Human (His) is 288 a.a., with molecular weight of ~35.7 kDa.

Cat. No.	Product Name	Chemical Structure

HY-113005S

Glutarylcarnitine-d9 chloride
Glutarylcarnitine-d₉ (chloride) is the deuterium labeled Glutarylcarnitine chloride. Glutarylcarnitine is the diagnostic metabolite for malonic aciduria and glutaric aciduria type I monitored in most tandem mass spectrometry newborn screening programmes.

HY-W008820S

Glutaric acid-d6
Glutaric acid-d₆ is the deuterium labeled Glutaric acid. Glutaric acid is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].

HY-110363

Miglustat-d9 hydrochloride
Miglustat-d₉ (hydrochloride) is the deuterium labeled Miglustat (hydrochloride). Miglustat hydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1)[1][2].

HY-17020S

Miglustat-d9
Miglustat-d9 is the deuterium labeled Miglustat. Miglustat (N-Butyldeoxynojirimycin) is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1) .

HY-W010452S1

3-Hydroxybutyric acid-13C4 sodium
3-Hydroxybutyric acid- ¹³C₄ (sodium) is the ¹³C labeled 3-Hydroxybutyric acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium is a metabolite that is elevated in type I diabetes, and can modulate the properties of membrane lipids[1].

HY-W010452S2

3-Hydroxybutyric acid-13C2 sodium
3-Hydroxybutyric acid- ¹³C₂ (sodium) is the ¹³C labeled 3-Hydroxybutyric acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium is a metabolite that is elevated in type I diabetes, and can modulate the properties of membrane lipids[1].

HY-W008820S1

Glutaric acid-d4
Glutaric acid-d₄ is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].

HY-113378S

3-Hydroxybutyric acid-d4 sodium
3-Hydroxybutyric acid-d₄ (sodium) is the deuterium labeled 3-Hydroxybutyric acid. 3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids[1].

HY-W008820S2

Glutaric acid-d2
Glutaric acid-d₂ is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].

HY-W010452S

3-Hydroxybutyric acid-d2 sodium
3-Hydroxybutyric acid-d₂ (sodium) is the deuterium labeled 3-Hydroxybutyric acid sodium[1]. 3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids[2].

HY-101037S1

Sarcosine-d3
Sarcosine-d₃ is the deuterium labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].

HY-101037S

Sarcosine-15N
Sarcosine- ¹⁵N is the ¹⁵N-labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].

HY-13635S

Finasteride-d9

Finasteride-d₉ is deuterium labeled Finasteride. Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia[1][2][3].

Cat. No.	Product Name	Application	Reactivity

HY-P81227

Collagen I Antibody Collagen type I; Alpha 1 type I collagen; Alpha 2 type I collagen; COL1A1; COL1A2; Collagen I alpha 1 polypeptide; Collagen I alpha 2 polypeptide; Collagen Of Skin Tendon And Bone; Collagen type 1; Collagen type I alpha 1; Collagen type I alpha 2; OI4; Osteogenesis Imperfecta type IV; Pro alpha 1(I) collagen; type I procollagen; CO1A1_HUMAN.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human, Mouse, Rat, Rabbit(predicted: Chicken, Dog, Cow, Sheep)
Collagen I Antibody is an unconjugated, approximately 130 kDa, rabbit-derived, anti-Collagen I polyclonal antibody. Collagen I Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, rat, rabbit, and predicted: chicken, dog, cow, sheep background without labeling.

HY-P80745

Liver Arginase Antibody Liver-type arginase; type I arginase	WB, IHC-P	Mouse, Rat
Liver Arginase Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 35 kDa, targeting to Liver Arginase. It can be used for WB,IHC-P assays with tag free, in the background of Mouse, Rat.

HY-P83259

Cytokeratin 12 Antibody (YA3004)

K12; Keratin 12; KRT12; type I cytoskeletal 12
WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P82789

Cytokeratin 17 Antibody (YA2534)

Keratin; type I cytoskeletal 17; Cytokeratin-17; CK-17; Keratin-17; K17
WB, IHC-P, IP Human
HY-P82131

Cytokeratin 14 Antibody (YA1876)

KRT14; Keratin; type I cytoskeletal 14; Cytokeratin-14; CK-14; Keratin-14; K14
WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P82112

Cytokeratin 10 Antibody (YA1857)

KRT10; KPP; Keratin; type I cytoskeletal 10; Cytokeratin-10; CK-10; Keratin-10; K10
WB, IHC-P Human, Hamster, Mouse, Rat
HY-P81266

Cytokeratin 16 Antibody (YA948)

KRT16; KRT16A; Keratin; type I cytoskeletal 16; Cytokeratin-16; CK-16; Keratin-16; K16
WB, IHC-P Human, Mouse, Rat
HY-P81266A

Cytokeratin 16 Antibody (YA949)

KRT16; KRT16A; Keratin; type I cytoskeletal 16; Cytokeratin-16; CK-16; Keratin-16; K16
WB, IHC-P Human
HY-P82950

Cytokeratin 13 Antibody (YA2695)

Keratin; type I cytoskeletal 13; Krt1-13; Cytokeratin 13; CK13; Keratin 13; KRT13; WSN2
WB, IHC-P, ICC/IF Human, Mouse

HY-P81748

Cytokeratin 15 Antibody (YA1493) CK-15; CK15; cytokeratin15; K15; K1C15; K1CO; keratin 15; Keratin-15; keratin-15; beta; KRT15; KRTB; type I cytoskeletal 15	WB, IHC-P, ICC/IF, FC	Human, Mouse

HY-P83367

Interferon alpha/beta Receptor 1 Antibody (YA3112) IFNAR1; IFNAR; Interferon alpha/beta receptor 1; IFN-R-1; IFN-alpha/beta receptor 1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; type I interferon receptor 1	WB, IP	Human

HY-P81183

Cytokeratin 19 Antibody 40 kDa keratin intermediate filament; CK 19; ck19; CK19; CK-19; KRT19; Cytokeratin19; Cytokeratin-19; k19; k1cs; Keratin 19; Keratin-19; Keratin type I 40 kD; Keratin type i 40kD; Keratin type I cytoskeletal 19; krt19; mgc15366; K1C19_HUMAN; Keratin, type I cytoskeletal 19; Keratin, type I, 40 kd.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human, Mouse(predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit)
Cytokeratin 19 Antibody is an unconjugated, approximately 44 kDa, rabbit-derived, anti-Cytokeratin 19 polyclonal antibody. Cytokeratin 19 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, and predicted: rat, chicken, dog, pig, cow, horse, rabbit background without labeling.

HY-P81250

Cytokeratin 19 Antibody (YA924) 40 kDa keratin intermediate filament; CK 19; ck19; CK19; CK-19; KRT19; Cytokeratin19; Cytokeratin-19; k19; k1cs; Keratin 19; Keratin-19; Keratin type I 40 kD; Keratin type i 40kD; Keratin type I cytoskeletal 19; krt19; mgc15366; K1C19_HUMAN; Keratin, type I cytoskeletal 19; Keratin, type I, 40 kd	WB, IHC-P, IHC-F, ICC, IF	Rat, Mouse, Human
Cytokeratin 19 Antibody is an unconjugated, approximately 44 kDa, mouse-derived, anti-Cytokeratin 19 monoclonal antibody. Cytokeratin 19 Antibody can be used for: WB, IHC-P, IHC-F,ICC, IF expriments in human, mouse, rat background without labeling.

HY-P80702

Hexokinase I Antibody (YA739) HK1; Hexokinase-1; Brain form hexokinase; Hexokinase type I; HK I	WB	Human, Mouse, Rat
Hexokinase I Antibody (YA739) is a non-conjugated and Mouse origined monoclonal antibody about 102 kDa, targeting to Hexokinase I (6B8). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P80627

Collagen I alpha 2 Antibody Collagen alpha-2(I) chain (Alpha-2 type I collagen)	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
Collagen I alpha 2 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 129 kDa, targeting to Collagen I alpha 2. It can be used for WB,IHC-F,IHC-P,ICC/IF,ELISA assays with tag free, in the background of Human, Mouse, Rat.

HY-P80878

Pyruvate Dehydrogenase E1 alpha Antibody (YA681) mitochondrial; ODPA_HUMAN; PDH; PDHA; PDHA1; PDHCE1A; PDHE1 A type I; PDHE1-A type I; PHE1A; Pyruvate Dehydrogenase (lipoamide) alpha 1; Pyruvate dehydrogenase complex; E1 alpha polypeptide 1; Pyruvate Dehydrogenase E1 alpha; Pyruvate dehydrogenase E1 com	WB, ICC/IF	Human, Mouse
Pyruvate Dehydrogenase E1 alpha Antibody (YA681) is a non-conjugated and Mouse origined monoclonal antibody about 43 kDa, targeting to Pyruvate Dehydrogenase E1 alpha (3H2). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse.

HY-P82006

PKA RI alpha Antibody (YA1751)

PRKAR1A; PKR1; PRKAR1; TSE1; cAMP-dependent protein kinase type I-alpha regulatory subunit; Tissue-specific extinguisher 1; TSE1
WB Human, Rat

HY-P82712

ALK-1 Antibody (YA2457) ACVRL1; ACVRLK1; ALK1; Serine/threonine-protein kinase receptor R3; SKR3; Activin receptor-like kinase 1; ALK-1; TGF-B superfamily receptor type I; TSR-I	WB	Human, Mouse, Rat

HY-P81707

Parathyroid Hormone Receptor 1 Antibody (YA1452) PTH1R; PTHR; PTHR1; Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHrP type I receptor; PTH/PTHr receptor; Parathyroid hormone 1 receptor; PTH1 receptor	WB, IP	Human

HY-P81181

CK18 Antibody K1C18_HUMAN; Keratin, type I cytoskeletal 18; KRT18; CYK18; Cell proliferation-inducing gene 46 protein; Cytokeratin-18 (CK-18); Keratin-18 (K18); PIG46; Keratin 18	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; ICC; IF	Human, Mouse, Rat(predicted: Dog, Pig, Cow, Horse, Rabbit)
CK18 Antibody is an unconjugated, approximately 48 kDa, rabbit-derived, anti-CK18 polyclonal antibody. CK18 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, ICC, IF expriments in human, mouse, rat, and predicted: dog, pig, cow, horse, rabbit background without labeling.

HY-P81637

2B4 Antibody (YA1382)

CD244; 2B4; Natural killer cell receptor 2B4; NK cell activation-inducing ligand; NAIL; NK cell type I receptor protein 2B4; NKR2B4; h2B4; CD244
FC, ELISA Human

HY-P81196

HSD3B1 Antibody 3BHS1_HUMAN; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; 3-beta-hydroxy-5-ene steroid dehydrogenase 1; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase 1; EC:1.1.1.145; 3-beta-hydroxysteroid 3-dehydrogenase 1; EC:1.1.1.270; Delta-5-3-ketosteroid isomerase; Dihydrotestosterone oxidoreductase. EC:1.1.1.210; Steroid Delta-isomerase 1; EC:5.3.3.1; Trophoblast antigen FDO161G; 3BH; HSDB3A	WB; ELISA; IHC-P; IHC-F; IF	Mouse, Rat(predicted: Human, Dog, Cow, Horse)
HSD3B1 Antibody is an unconjugated, approximately 41 kDa, rabbit-derived, anti-HSD3B1 polyclonal antibody. HSD3B1 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in mouse, rat, and predicted: human, dog, cow, horse background without labeling.

Cat. No.	Product Name		Classification

HY-152478

3’-β-C-Ethynylguanosine		Alkynes
3’-β-C-Ethynylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . 3’-β-C-Ethynylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-154361

TLR7 agonist 13		Alkynes
TLR7 agonist 13 is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . TLR7 agonist 13 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-154349

N2-iso-Butyroyl-2’-O-propargylguanosine		Alkynes
N2-iso-Butyroyl-2’-O-propargylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . N2-iso-Butyroyl-2’-O-propargylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-152684

2′-O-2-Propyn-1-ylguanosine		Alkynes
2′-O-2-Propyn-1-ylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . 2′-O-2-Propyn-1-ylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.


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