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Results for "

tyrosinase

" in MCE Product Catalog:

By Targets:	Tyrosinase (89) AMPK (2) Antibiotic (1) Apoptosis (3) Autophagy (4) Bacterial (6) Biochemical Assay Reagents (1) COX (1) DNA/RNA Synthesis (1) Elastase (1) Endogenous Metabolite (12) ERK (1) Fungal (3) Glucosidase (2) HDAC (1) HSV (1) Interleukin Related (2) MAPKAPK2 (MK2) (1) Melanocortin Receptor (3) NF-κB (1) Parasite (1) Phosphatase (1) PPAR (1) Raf (1) Ras (1) Sirtuin (1) TGF-beta/Smad (1) TNF Receptor (2)
By Research Areas:	Cancer (35) Cardiovascular Disease (2) Endocrinology (5) Infection (11) Inflammation/Immunology (17) Metabolic Disease (23) Neurological Disease (2)

By Targets:

Tyrosinase (89)

AMPK (2)

Antibiotic (1)

Apoptosis (3)

Autophagy (4)

Bacterial (6)

Biochemical Assay Reagents (1)

COX (1)

DNA/RNA Synthesis (1)

Elastase (1)

Endogenous Metabolite (12)

ERK (1)

Fungal (3)

Glucosidase (2)

HDAC (1)

HSV (1)

Interleukin Related (2)

MAPKAPK2 (MK2) (1)

Melanocortin Receptor (3)

NF-κB (1)

Parasite (1)

Phosphatase (1)

PPAR (1)

Raf (1)

Ras (1)

Sirtuin (1)

TGF-beta/Smad (1)

TNF Receptor (2)

By Research Areas:

Cancer (35)

Cardiovascular Disease (2)

Endocrinology (5)

Infection (11)

Inflammation/Immunology (17)

Metabolic Disease (23)

Neurological Disease (2)

108

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: Tyrosinase

Cat. No.	Product Name	Target	Research Areas

HY-125860

*Tyrosinase* Polyphenol oxidase	Tyrosinase	Metabolic Disease
Tyrosinase (Polyphenol oxidase) is a rate-limiting enzyme that controls the production of melanin and is encoded by TYR gene. Tyrosinase is mainly found in melanosomes synthesized by skin melanocytes.

HY-143459

Tyrosinase-IN-5	Tyrosinase	Cancer
Tyrosinase-IN-5 (compound 16c) is a potent inhibitor of *tyrosinase* with an IC₅₀ of 0.02 μM. Tyrosinase-IN-5 efficiently suppresses the melanogenesis without significant toxicity on cells.

HY-149207

Tyrosinase-IN-11	Tyrosinase	Metabolic Disease
Tyrosinase-IN-11 is a potent *tyrosinase* inhibitor with IC₅₀s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research.

HY-P3813

Tyrosinase (206-214), human	Tyrosinase	Cancer Inflammation/Immunology
Tyrosinase (206-214), human (AFLPWHRLF), a 9-amino acid peptide, is a tyrosinase epitope. Tyrosinase (206-214), human can be recognized by HLA-A24 restricted, tumor-infiltrating lymphocytes (TIL).

HY-143448

Tyrosinase-IN-1	Tyrosinase	Others
Tyrosinase-IN-1 (compound 90) is a potent inhibitor of *tyrosinase. Tyrosinase* is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-1 has the potential for the research of skin whitening agents and food preservatives.

HY-143450

Tyrosinase-IN-3	Tyrosinase	Others
Tyrosinase-IN-3 (compound 54) is a potent inhibitor of *tyrosinase. Tyrosinase* is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-3 has the potential for the research of skin whitening agents and food preservatives.

HY-143451

Tyrosinase-IN-4	Tyrosinase	Others
Tyrosinase-IN-4 (compound 34) is a potent inhibitor of *tyrosinase. Tyrosinase* is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-4 has the potential for the research of skin whitening agents and food preservatives.

HY-143449

Tyrosinase-IN-2	Tyrosinase	Others
Tyrosinase-IN-2 (compound 67) is a potent inhibitor of *tyrosinase. Tyrosinase* is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-2 has the potential for the research of skin whitening agents and food preservatives.

HY-151977

Tyrosinase-IN-7
Tyrosinase Cancer

Tyrosinase-IN-7 is a potent tyrosinase inhibitor with an IC₅₀ value of 1.57 µM. Tyrosinase-IN-7 inhibits cell growth with low cytotoxicity.
HY-151979

Tyrosinase-IN-8
Tyrosinase Cancer

Tyrosinase-IN-8 is a potent tyrosinase inhibitor with an IC₅₀ value of 1.6 µM. Tyrosinase-IN-8 inhibits cell growth with low cytotoxicity.

Tyrosinase-IN-7	Tyrosinase	Cancer
Tyrosinase-IN-7 is a potent *tyrosinase* inhibitor with an IC₅₀ value of 1.57 µM. Tyrosinase-IN-7 inhibits cell growth with low cytotoxicity.

Tyrosinase-IN-8	Tyrosinase	Cancer
Tyrosinase-IN-8 is a potent *tyrosinase* inhibitor with an IC₅₀ value of 1.6 µM. Tyrosinase-IN-8 inhibits cell growth with low cytotoxicity.

HY-152194

Tyrosinase-IN-10	Tyrosinase	Cancer
Tyrosinase-IN-10 (Compound 23) is a partially competitive *tyrosinase* inhibitor with an IC₅₀ of 1.6 μM against tyrosinase activity from human melanoma cell lysates.

HY-143206

Tyrosinase/elastase-IN-1
Elastase Others

Tyrosinase/elastase-IN-1 a triterpenoid from Rubus fraxinifolius leaves, has tyrosinase and elastase inhibitory activities.
HY-147709

Tyrosinase-IN-6
Tyrosinase Others

Compound 4B proved to be the most effective tyrosinase inhibitor (ic₅₀= 3.80 μ M) It also showed good antioxidant activity.

Tyrosinase/elastase-IN-1	Elastase	Others
Tyrosinase/elastase-IN-1 a triterpenoid from Rubus fraxinifolius leaves, has tyrosinase and elastase inhibitory activities.

Tyrosinase-IN-6	Tyrosinase	Others
Compound 4B proved to be the most effective tyrosinase inhibitor (ic₅₀= 3.80 μ M) It also showed good antioxidant activity.

HY-122933

Kurarinol	Tyrosinase Apoptosis	Cancer Cardiovascular Disease
Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive *tyrosinase* inhibitor, with IC₅₀ of 0.1 μM for mushroom tyrosinase.

HY-N3002

α-Arbutin 4-Hydroxyphenyl α-D-glucopyranoside	Tyrosinase	Metabolic Disease
α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is emerging as popular and effective skin whiteners, acting as *tyrosinase* inhibitor.

HY-N10219

Dihydroaltenuene B	Tyrosinase Fungal	Infection
Dihydroaltenuene B is a potent mushroom tyrosinase inhibitor with an IC₅₀ of 38.33 µM. Dihydroaltenuene B shows the hydrogen bonding interactions between the 3-OH and 4’-OH and the His244, Met280 and Gly281 residues of tyrosinase.

HY-W015782

4-Ethylresorcinol	Others	Metabolic Disease
4-Ethylresorcinol, a derivative of resorcinol, can act as substrates of tyrosinase. 4-Ethylresorcinol possess hypopigmentary effects. 4-Ethylresorcinol attenuates mRNA and protein expression of tyrosinase-related protein (TRP)-2, and possessed antioxidative effect by inhibiting lipid peroxidation.

HY-P3452

Tetrapeptide-30	Tyrosinase	Inflammation/Immunology
Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation.

HY-W013571

4-Isopropylbenzoic acid	Fungal	Infection
4-Isopropylbenzoic acid, an aromatic monoterpenoid, is isolated from the stem bark of Bridelia retusa. 4-Isopropylbenzoic acid exhibits antifungal activities. 4-Isopropylbenzoic acid is also a reversible and uncompetitive inhibitor of mushroom tyrosinase.

HY-N2134

Mirificin Puerarin apioside	Tyrosinase	Endocrinology
Mirificin (Puerarin apioside) is a isoflavone in Puerariae Lobatae Radix. Mirificin inhibits tyrosinase (TYR) with an IC₅₀ of 12.66 μM.

HY-133680

β-Tocopherol	Tyrosinase	Metabolic Disease
β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit *tyrosinase* activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol.

HY-P0096

Decapeptide-12	Tyrosinase Sirtuin	Endocrinology Inflammation/Immunology
Decapeptide-12, a small oligopeptide, is a *tyrosinase* inhibitor that interacts with C-terminal residue of tyrosinase (K_d: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC₅₀: 40 µM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .

HY-W019829

Polyphyllin C	Tyrosinase Parasite	Infection
Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC₅₀=36.87 µM) activities against the *tyrosinase* and moderate (IC₅₀=1.59 µg/mL) antileishmanial activities.

HY-N10286

Chetoseminudin B
Tyrosinase Others

Chetoseminudin B possesses mushroom tyrosinase inhibitory activity with IC₅₀ of 31.7 μM.

Chetoseminudin B	Tyrosinase	Others
Chetoseminudin B possesses mushroom tyrosinase inhibitory activity with IC₅₀ of 31.7 μM.

HY-116750

6-Hydroxykaempferol	Others	Others
6-Hydroxykaempferol, a flavonoid, is a competitive *tyrosinase* inhibitor with an IC₅₀ value of 124 μM. 6-Hydroxykaempferol has a K_i value of 148 μM relative to L-DOPA as a substrate and effectively inhibits the activity of the enzyme by binding to the active site of the enzyme.

HY-N10285

Phaeosphaone D	Tyrosinase	Infection
Phaeosphaone D is a thiodiketopiperazine alkaloid compound isolated from Phaeosphaeria fuckelii, an endophytic fungus. Phaeosphaone D displays mushroom tyrosinase inhibitory activity with an IC₅₀ value of 33.2 μM.

HY-N7135

Tropolone	Tyrosinase	Others
Tropolone, a tropone derivative with a hydroxyl group in the 2-position, is a precursor of manyazulene derivatives such as methyl 2-methylazulene-1-carboxylate. Tropolone is a potent inhibitor of mushroom tyrosinase with a IC₅₀ of 0.4 μM, and the inhibition can be reversed by dialysis or by excess CU²⁺.

HY-N0637A

(±)-Eriodictyol (±)-Huazhongilexone	Melanocortin Receptor	Metabolic Disease
(±)-Eriodictyol ((±)-Huazhongilexone), a flavonoid, is a potent melanogenesis inhibitor with an IC₅₀ of 48 μM. (±)-Eriodictyol suppresses tyrosinase, TRP-1, and TRP-2 mRNA expression. (±)-Eriodictyol has strong anti-plasmin activities.

HY-Y0444

D-Tyrosine	Tyrosinase	Metabolic Disease
D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting *tyrosinase* activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth.

HY-N3023

3,4-Dihydroxybenzylamine hydrobromide NSC 263475 hydrobromide	DNA/RNA Synthesis	Cancer
3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) is an improved dopamine analog cytotoxic and inhibits DNA polymerase activity in melanoma cells. 3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity.

HY-N1658

2,3-Dihydroisoginkgetin	Tyrosinase	Others
2,3-Dihydroisoginkgetin, a biflavonoid, is a inhibitor of *Tyrosinase, with 36.84% inhibition at 0.1 mM. 2,3-Dihydroisoginkgetin shows less toxicity in HEMn (human epidermal melanocytes) cells, with an IC₅₀* of 86.16 μM.

HY-143452

MtTMPK-IN-4	Tyrosinase Bacterial	Inflammation/Immunology
MtTMPK-IN-4 (compound 2), a para-piperidine, is a potent mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC₅₀ of 6.1 μM. MtTMPK-IN-4 is a potent *tyrosinase* inhibitor. MtTMPK-IN-4 is a potent antibacterial agent.

HY-134046

(-)-Isodocarpin Isodocarpin	Melanocortin Receptor	Metabolic Disease
(-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC₅₀ of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA.

HY-N1780

3,4-Dimethoxyphenol	Tyrosinase	Endocrinology Metabolic Disease
3,4-Dimethoxyphenol is a plant-derived phenylpropanoid compound and can use as a whitening agent in cosmetics. 3,4-Dimethoxyphenol has *tyrosinase*-inhibiting activity. 3,4-Dimethoxyphenol has potent antioxidant effect isolated from the bacterial fermentation broth.

HY-B0856

Validamycin A	Fungal Tyrosinase Antibiotic	Infection
Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL. Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC₅₀ of 72 μM. Validamycin A is a reversible *tyrosinase* inhibitor, with a K_i of 5.893 mM.

HY-P4497

Prolylserine	ERK Others	Cancer
Prolylserine, a dipeptide, is an inhibitor of melanogenesis production in Mel-Ab cells. Prolylserine decreases expression of microphthalmia-associated transcription factor (MITF) and *tyrosinase, induces phorphosylation of ERK, but not cAMP response element binding protein (CREB)*.

HY-N10503

Norartocarpetin	Tyrosinase Ras Raf MAPKAPK2 (MK2) Apoptosis	Cancer
Norartocarpetin is a *tyrosinase* inhibitor. Norartocarpetin has strong tyrosinase inhibitory activity with an IC₅₀ value of 0.47 μM. Norartocarpetin as an antibrowning agent can be used for the research of food systems. Norartocarpetin also has a significant anticancer activity in lung carcinoma cells (NCI-H460) with an IC₅₀ value of 22 μM. Norartocarpetin has antiproliferative effects are mediated via targeting Ras/Raf/MAPK signalling pathway, mitochondrial mediated apoptosis, S-phase cell cycle arrest and suppression of cell migration and invasion in human lung carcinoma cells.

HY-N1386

2-Methoxycinnamic acid
Tyrosinase Metabolic Disease

2-Methoxycinnamic acid is a noncompetitive inhibitor of tyrosinase.

2-Methoxycinnamic acid	Tyrosinase	Metabolic Disease
2-Methoxycinnamic acid is a noncompetitive inhibitor of *tyrosinase*.

HY-N6244

Isolindleyin	Tyrosinase	Inflammation/Immunology
Isolindleyin, a butyrophenone, is a *tyrosinase* inhibitor, with a K_d of 54.8 μM for human tyrosinase. Isolindleyin exhibits anti-inflammatory, analgesic and anti-melanogenic activities.

HY-N2278

Kushenol A Leachianone E	Tyrosinase Glucosidase	Cancer
Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive *tyrosinase* inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC₅₀ and K_ivalues of 1.1 μM and 0.4 μM, respectively. Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC₅₀: 45 μM; K_i: 6.8 μM) and β-amylase. Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging.

HY-N3266

Methyl rosmarinate	Tyrosinase	Cancer
Methyl rosmarinate is a noncompetitive *tyrosinase* inhibitor which is isolated from Rabdosia serra, with an IC₅₀ of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase.

HY-N2204

Swertiajaponin	Tyrosinase	Inflammation/Immunology
Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC₅₀ of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity.

HY-N10623

5-epi-Arvestonate A	Tyrosinase	Cancer
5-epi-Arvestonate A is a sesquiterpenoid isolated from the whole plants of Seriphidium transiliense. 5-epi-Arvestonate A promotes melanogenic production by activating the transcription of microphthalmia-associated transcription factor (MITF) and tyrosinase family genes. 5-epi-Arvestonate A inhibits the expression of IFN-γ-chemokine through the JAK/STAT signaling pathway in immortalized human keratinocyte (HaCaT) cells.

HY-N3748

Dihydromorin
Tyrosinase Cancer

Dihydromorin, a natural flavanonol compound, is a tyrosinase inhibitor.

Dihydromorin	Tyrosinase	Cancer
Dihydromorin, a natural flavanonol compound, is a *tyrosinase* inhibitor.

HY-N3200

Neorauflavane	Tyrosinase	Cancer
Neorauflavane is a potent *tyrosinase* inhibitor derived from Campylotropis hirtella, with an IC₅₀ value of 30 nM for tyrosinase monophenolase activity and an IC₅₀ value of 500 nM for diphenolase activity. Neorauflavane can effectively reduce the melanin content of B16 melanoma cells.

HY-W015967

Glycolic acid Hydroxyethanoic acid	Endogenous Metabolite Tyrosinase	Metabolic Disease
Glycolic acid is an inhibitor of *tyrosinase*, suppressing melanin formation and lead to a lightening of skin colour.

HY-101445A

(R)-Trolox	Tyrosinase	Cancer
(R)-Trolox is a vitamin E analogue and a competitive *tyrosinase* inhibitor with a K_i value of 0.83 mM and a ID₅₀ value of 1.88 mM. The (R)-Trolox has stronger *tyrosinase* affinity than the (S) enantiomer (K_i value of 0.61 mM).

HY-N2101

Benzoyloxypaeoniflorin	Tyrosinase NF-κB	Inflammation/Immunology
Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a *tyrosinase* inhibitor against mushroom tyrosinase with IC₅₀ of 0.453 mM. Benzoyloxypaeoniflorin is NF-κB Inhibitor and contributes to improving blood circulation through its inhibitory effect on both platelet aggregation and blood coagulation.

HY-139857

Piceid 6″-O-azelaic acid ester
Others Others

Piceid 6″-O-azelaic acid ester shows high intracellular tyrosinase inhibitory and depigmentating activities.
HY-N10287

Leptosin D
Tyrosinase Infection

Leptosin D, a thiodiketopiperazine alkaloid, is a mushroom tyrosinase inhibitor, with an IC₅₀ of 28.4 μM.
HY-107369

4-Butylresorcinol
Butylresorcinol
Tyrosinase Others

4-Butylresorcinol is a phenol derivative which can inhibit tyrosinase with IC₅₀ of 11.27 μM.
HY-131327

Azo-resveratrol
Tyrosinase Cancer

Azo-resveratrol, an Azo compound, inhibits Mushroom tyrosinase (IC₅₀=36.28 μM).
HY-N3425

Kazinol U
AMPK Others

Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK activation.
HY-N7929

5-Feruloylquinic acid
Tyrosinase Cancer

5-Feruloylquinic acid (5-FQA) possesses antioxidative effects and tyrosinase inhibitory activities.
HY-N11521

7-Methoxy obtusifolin
Tyrosinase Cancer

7-Methoxy obtusifolin (Compound 4) is a competitive tyrosinase inhibitor with an IC₅₀ of 7.0 μM.
HY-N3101

Pedalitin
Endogenous Metabolite Tyrosinase Glucosidase Endocrinology

Pedalitin is a inhibitor of tyrosinase（IC₅₀=0.28 mM） and α-glucosidase（IC₅₀=0.29 mM）.

HY-B1461

Deoxyarbutin	Tyrosinase	Others
Deoxyarbutin is a new effective lighten ingredient, can effectively inhibit tyrosinase activity and melanin synthesis to get significant and lasting lightening effect.

HY-N5118

Chimonanthine (-)-Chimonanthine	Tyrosinase	Cancer
Chimonanthine is an alkaloid of Chimonanthus praecox, inhibits tyrosinase and tyrosine-related protein-1 mRNA expression, amd inhibits melanogenesis.

HY-W015967S

Glycolic acid-d2	Endogenous Metabolite Tyrosinase	Metabolic Disease
Glycolic acid-d₂ is the deuterium labeled Glycolic acid. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

HY-N1430

Oxyresveratrol trans-Oxyresveratrol	Tyrosinase HSV Autophagy	Others
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC₅₀ of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive *tyrosinase* inhibitor with an IC₅₀ value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects.

HY-N8223

Viscumneoside III	Tyrosinase	Cardiovascular Disease
Viscumneoside III, a dihydroflavone O-glycoside, is a potent *tyrosinase* inhibitor with an IC₅₀ of 0.5 mM. Viscumneoside III has anti-angina pectoris.

HY-N3943

Glabrene
Tyrosinase Neurological Disease

Glabrene, an isoflavene derived from licorice root, shows estrogen-like activity. Glabrene is a tyrosinase inhibitor with an IC₅₀ of 3.5 μM.

HY-126052

Gnetol	COX Tyrosinase HDAC	Cancer Metabolic Disease
Gnetol is a phenolic compound isolated from the root of Gnetum montanum . Gnetol potently inhibits COX-1 (IC₅₀ of 0.78 μM) and HDAC. Gnetol is a potent *tyrosinase* inhibitor with an IC₅₀ of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities.

HY-N3517

Oxyresveratrol 3'-O-β-D-glucopyranoside	Tyrosinase	Metabolic Disease
Oxyresveratrol 3'-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective *tyrosinase* inhibitor with an IC₅₀ of 1.64 μM.

HY-N3516

Oxyresveratrol 2-O-β-D-glucopyranoside	Tyrosinase	Metabolic Disease
Oxyresveratrol 2-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective *tyrosinase* inhibitor with an IC₅₀ of 29.75 μM.

HY-N3773

Dodoviscin A	Tyrosinase	Cancer
Dodoviscin A is a pigmentation-altering agent, which can be isolated from the aerial parts of Dodonaea viscosa. Dodoviscin A inhibits melanin production in B16-F10 melanoma cells. Dodoviscin A suppresses mushroom tyrosinase activity, and tyrosinase activity induced by 3-isobutyl-1-methylxanthine. Dodoviscin A also inhibits the phorphosylation of cAMP response element binding protein, induced by 3-isobutyl-1-methylxanthine and forskolin.

HY-N2460

Aloesin Aloeresin	Tyrosinase Apoptosis	Cancer Infection Inflammation/Immunology
Aloesin (Aloeresin) is a *tyrosinase* inhibitor, and shows anti-inflammatory activity, ultraviolet protection, and antibacterium effects. Aloesin can induce apoptosis and be used in ovarian cancer research.

HY-N3912

Furomollugin	Bacterial	Cancer Infection
Furomollugin is a natural product with antioxidant and antibacterial activities, can be isolated from Rubia cordifolia. Furomollugin lacks potent anti-tyrosinase activity, but also exhibits significant anticancer property.

HY-N3674

Dalbergioidin	TGF-beta/Smad	Inflammation/Immunology
Dalbergioidin, a well-known anthocyanin, ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-β signal pathway. Dalbergioidin exhibits tyrosinase inhibitory activity with an IC₅₀ of 20 mM.

HY-117761

MHY908
PPAR Cancer Metabolic Disease

MHY908 is a potent dual agonist of PPARα and PPARγ. MHY908 also inhibits melanogenesis through inhibition of mushroom tyrosinase activity.

HY-N1481

Methyl linoleate	Others	Metabolic Disease
Methyl linoleate, a major active constituent of Sageretia thea fruit (HFSF), is a major anti-melanogenic compound. Methyl linoleate downregulates microphthalmia-associated transcription factor (MITF) and tyrosinase-related proteins.

HY-N1750

3-(2,4-Dihydroxyphenyl)propanoic acid	Tyrosinase Endogenous Metabolite	Others
3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) is a potent and competitive *tyrosinase* inhibitor, inhibits L-Tyrosine and DL-DOPA with an IC₅₀ and a K_i of 3.02 μM and 11.5 μM, respectively.

HY-136595

3,5-Difluoro-L-tyrosine	Phosphatase	Others
3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine. 3,5-Difluoro-L-tyrosine can be used to analyze the substrate specificity of protein tyrosine phosphatases (PTPs).

HY-W003607

3-O-Ethyl-L-ascorbic acid	Tyrosinase	Others
3-O-Ethyl-L-ascorbic acid, a stable vitamin C derivative, is a cosmetic *tyrosinase* tnhibitor with a whitening capacity. 3-O-Ethyl-L-ascorbic acid also has antioxidant abilities.

HY-N0616

Trifolirhizin	Tyrosinase	Cancer Inflammation/Immunology
Trifolirhizin is a pterocarpan flavonoid isolated from the roots of Sophora flavescens. Trifolirhizin possesses potent *tyrosinase* inhibitory activity with an IC₅₀ of 506 μM. Trifolirhizin exhibits potential anti-inflammatory and anticancer activities.

HY-N11063

Obtusifolin-2-O-glucoside	Tyrosinase	Cancer
Obtusifolin-2-O-glucoside (compound 7) is a *Tyrosinase* inhibitor (IC₅₀=9.2 μM). Obtusifolin-2-O-glucoside can be isolated from cassia seed.

HY-N10437

6-Acetylnimbandiol 6-O-Acetylnimbandiol	Tyrosinase	Cancer
6-Acetylnimbandiol (6-O-Acetylnimbandiol) is a non-cytotoxic *tyrosinase* inhibitor (IC₅₀=69.85 μM) that effectively inhibits melanin production and MITF expression. 6-Acetylnimbandiol can be used in melanoma research.

HY-N0136

Taxifolin (+)-Dihydroquercetin; (+)-Taxifolin	Autophagy Tyrosinase	Inflammation/Immunology
Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.

HY-N3518

Mulberroside F	Tyrosinase	Metabolic Disease
Mulberroside F is one of the main bioactive constituents in mulberry (Morus alba L.). Mulberroside F shows inhibitory effects on *tyrosinase* activity and on the melanin formation. Mulberroside F also exhibits superoxide scavenging activity that is involved in the protection against auto-oxidation.

HY-W099579

Kojic acid dipalmitate Kojic dipalmitate	Tyrosinase	Endocrinology
Kojic acid dipalmitate (Kojic dipalmitate) is a derivative of Kojic acid (HY-W050154), a fungal metabolite that can be produced by species of Aspergillus, Acetobacter and Penicillium. Kojic acid dipalmitate is a slow and reversible competitive inhibitor of *tyrosinase*. Kojic acid dipalmitate can be used for skin‐lightening agent research.

HY-W013636

2-Ketoglutaric acid Alpha-Ketoglutaric acid	Tyrosinase Endogenous Metabolite	Others
2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of *tyrosinase* (IC₅₀=15 mM).

HY-N2472

Medicagenic acid Castanogenin	Bacterial	Infection
Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes. Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE.

HY-W013636B

Calcium 2-oxoglutarate	Tyrosinase Endogenous Metabolite	Metabolic Disease
Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of *tyrosinase* (IC₅₀=15 mM).

HY-W013636A

2-Ketoglutaric acid Sodium Alpha-Ketoglutaric acid Sodium	Tyrosinase Endogenous Metabolite	Metabolic Disease
2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of *tyrosinase* (IC₅₀=15 mM).

HY-N0136A

(±)-Taxifolin (±)-Dihydroquercetin	Autophagy Tyrosinase	Inflammation/Immunology
(±)-Taxifolin ((±)-Dihydroquercetin) is the racemate of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.

HY-N1775

3',4'-Dihydroxyacetophenone 3,4-DHAP	Tyrosinase	Cancer
3',4'-Dihydroxyacetophenone (3,4-DHAP), isolated from Picea Schrenkiana Needles exhibits a strong suppressive action against *tyrosinase* activity, with an IC₅₀ of 10 μM. 3',4'-Dihydroxyacetophenone (3,4-DHAP) is a vasoactive agent and antioxidant.

HY-N0136B

(-)-Taxifolin (-)-Dihydroquercetin	Tyrosinase	Inflammation/Immunology
(-)-Taxifolin is the less active enantiomer of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.

HY-Y0444S

D-Tyrosine-d2	Tyrosinase
D-Tyrosine-d₂ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-Y0444S1

D-Tyrosine-d4	Tyrosinase
D-Tyrosine-d₄ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-Y0444S2

D-Tyrosine-d7	Tyrosinase
D-Tyrosine-d₇ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-N4005

Isoastilbin	Bacterial Tyrosinase	Infection Neurological Disease
Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC₅₀ value of 54.3 μg/mL, and also inhibits *tyrosinase* activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research.

HY-N0192

Arbutin β-Arbutin	Tyrosinase Endogenous Metabolite	Cancer
Arbutin (β-Arbutin) is a competitive inhibitor of *tyrosinase, with K_i^app* values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties.

HY-N0136S

Taxifolin-d3 (+)-Dihydroquercetin-d₃; (+)-Taxifolin-d₃	Autophagy Tyrosinase	Inflammation/Immunology
Taxifolin-d₃ is deuterium labeled Taxifolin. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].

HY-113068

(rel)-β-Tocopherol	Tyrosinase	Metabolic Disease
(rel)-β-Tocopherol is a relative configuration of β-Tocopherol.(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol.

HY-N0445

2-Hydroxy-4-methoxybenzaldehyde	Tyrosinase Bacterial	Others
2-Hydroxy-4-methoxybenzaldehyde, a chemical compound and an isomer of Vanillin, could be used to synthesis Urolithin M7. 2-hydroxy-4-methoxybenzaldehyde is a potent *tyrosinase* inhibitor from three East African medicinal plants, Mondia whitei, Rhus vulgaris Meikle, and Sclerocarya caffra Sond.

HY-P99622

Flanvotumab IMC-20D7S	Tyrosinase	Cancer
Flanvotumab (IMC-20D7S) is a human monoclonal antibody targeting to tyrosinase-related protein (TYRP1), specifically expressed in melanocytes and melanoma cells. Flanvotumab acts function via natural killing-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). Flanvotumab has potent anti-tumor activity and good tolerance.

HY-P3645

(Nle4)-α-MSH	Melanocortin Receptor	Others
(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment.

HY-113068S

β-Tocopherol-d3	Tyrosinase	Metabolic Disease
β-Tocopherol-d₃ is the deuterium labeled β-Tocopherol. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol can also prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol[1][2][3].

HY-W013636S1

2-Ketoglutaric acid-d4 Alpha-Ketoglutaric acid-d₄	Tyrosinase Endogenous Metabolite	Others
2-Ketoglutaric acid-d₄ is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

HY-N0192S

Arbutin-d4 β-Arbutin-d₄	Tyrosinase Endogenous Metabolite	Cancer
Arbutin-d₄ is deuterium labeled Arbutin. Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents[1]. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[2][3].

HY-W013636S2

2-Ketoglutaric acid-d6	Tyrosinase Endogenous Metabolite	Others
2-Ketoglutaric acid-d₆ is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

HY-W013636S

2-Ketoglutaric acid-13C5	Tyrosinase Endogenous Metabolite	Others
2-Ketoglutaric acid-¹³C₅ is the ¹³C labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

HY-P3662

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2	Tyrosinase	Cancer
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates *tyrosinase* and exhibits thermoregulatory effect in rats model.

HY-W017212

Methyl cinnamate Methyl 3-phenylpropenoate	Tyrosinase Bacterial AMPK	Infection Metabolic Disease
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a *tyrosinase* inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway.

HY-N0619

Mulberroside A	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.). Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects. Mulberroside A shows inhibitory activity against mushroom *tyrosinase* with an IC₅₀ of 53.6 μM.

HY-N2983

Cajanin	Others	Others
Cajanin is a potent and orally active anti-melanogenic agent. Cajanin shows antiproliferative activity in MNT1 Cells. Cajanin efficiently decreases the melanin content. Cajanin down-regulates the mRNA and protein expression levels of MITF, tyrosinase, TRP-1 and Dct (TRP-2). Cajanin induces cell cycle arrest at G2/M and S phase. Cajanin stimulates osteoblast proliferation. Cajanin has the potential for the research of human hyperpigmented disorders and menopausal osteoporosis.

HY-D1840

Tyramide Amplification Buffer	Biochemical Assay Reagents	Others
Tyramide Amplification Buffer is a ready-to-use buffer primarily intended for immunostaining of cells and tissues by the technique of tyramide signal amplification (TSA). TSA Technology is based on a tyrosinase labeling system that reacts a tyrosine-labeled antibody with a fluorescently labeled tyramide using peroxidase to form a highly amplified fluorescent signal. For example, horseradish peroxidase (HRP) can catalyze the reaction of tyrosine and hydrogen peroxide under milder conditions to generate epoxy groups. Epoxy groups promote the binding of tyramide to adjacent amino acids to form fluorescently labeled products.

HY-N0619A

cis-Mulberroside A Mulberroside D	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.). Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects. Mulberroside A shows inhibitory activity against mushroom *tyrosinase* with an IC₅₀ of 53.6 μM.

Cat. No.	Product Name	Type

HY-D1840

Tyramide Amplification Buffer

Dyes

Tyramide Amplification Buffer is a ready-to-use buffer primarily intended for immunostaining of cells and tissues by the technique of tyramide signal amplification (TSA). TSA Technology is based on a tyrosinase labeling system that reacts a tyrosine-labeled antibody with a fluorescently labeled tyramide using peroxidase to form a highly amplified fluorescent signal. For example, horseradish peroxidase (HRP) can catalyze the reaction of tyrosine and hydrogen peroxide under milder conditions to generate epoxy groups. Epoxy groups promote the binding of tyramide to adjacent amino acids to form fluorescently labeled products.

Cat. No.	Product Name	Type

HY-125860

*Tyrosinase* Polyphenol oxidase	Enzyme
Tyrosinase (Polyphenol oxidase) is a rate-limiting enzyme that controls the production of melanin and is encoded by TYR gene. Tyrosinase is mainly found in melanosomes synthesized by skin melanocytes.

Cat. No.	Product Name	Target	Research Area

HY-P3813

Tyrosinase (206-214), human	Tyrosinase	Cancer Inflammation/Immunology
Tyrosinase (206-214), human (AFLPWHRLF), a 9-amino acid peptide, is a tyrosinase epitope. Tyrosinase (206-214), human can be recognized by HLA-A24 restricted, tumor-infiltrating lymphocytes (TIL).

HY-P3742

Tyrosinase (192-200), human mouse	Peptides	Cancer
Tyrosinase (192-200), human mouse is a nonapeptide. Tyrosinase (192-200), human mouse can be recognized by cytolytic T cell (CTL) on the HLA-B44 molecule. Tyrosinase (192-200), human mouse can be used in research of melanoma associated cancers.

HY-P2527

Tyrosinase-related Protein 2 (TRP-2) (181-188)	Peptides	Inflammation/Immunology
Tyrosinase-related Protein 2 (TRP-2) (181-188) is a tyrosinase-related protein 2 (TRP-2)-derived peptide, corresponding to residues 180-188. Tyrosinase-related Protein 2 (TRP-2) (181-188) is the major reactive epitope within TRP-2 recognized by anti-B16 CTLs. Tyrosinase-related Protein 2 (TRP-2) (181-188) is a peptide conforming to the MHC class I H2-Kb binding motif.

HY-P1919

*[Asp371]-Tyrosinase* (369-377), human**	Peptides	Cancer
Tyrosinase 369-377, human is a HLA-A2.1-restricted epitope derived from tyrosinase, has been used to develop tumor-targeted vaccines with mixed efficacy.

HY-P3452

Tetrapeptide-30	Tyrosinase	Inflammation/Immunology
Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation.

HY-P0096

Decapeptide-12	Tyrosinase Sirtuin	Endocrinology Inflammation/Immunology
Decapeptide-12, a small oligopeptide, is a *tyrosinase* inhibitor that interacts with C-terminal residue of tyrosinase (K_d: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC₅₀: 40 µM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .

HY-P4497

Prolylserine	ERK Peptides	Cancer
Prolylserine, a dipeptide, is an inhibitor of melanogenesis production in Mel-Ab cells. Prolylserine decreases expression of microphthalmia-associated transcription factor (MITF) and *tyrosinase, induces phorphosylation of ERK, but not cAMP response element binding protein (CREB)*.

HY-P3639

SYLQDSVPDSFQD
Peptides Others

SYLQDSVPDSFQD, anchor-modified for high-affinity binding to DR4, is a DR4-restricted MHC class II peptide Tyrosinase.

HY-P1827

mTRP-2 (180-188)	Peptides	Cancer
mTRP-2 (180-188) is a murine tyrosinase-related protein 2 (TRP-2) -derived peptide, corresponding to residues 180-188. TRP-2 (180-188) is identified as the major reactive epitope within TRP-2 recognized by anti-B16 CTLs.

HY-P3645

(Nle4)-α-MSH	Melanocortin Receptor	Others
(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment.

HY-P3662

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2	Tyrosinase	Cancer
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates *tyrosinase* and exhibits thermoregulatory effect in rats model.

Cat. No.	Product Name	Target	Research Area

HY-P99622

Flanvotumab IMC-20D7S	Tyrosinase	Cancer
Flanvotumab (IMC-20D7S) is a human monoclonal antibody targeting to tyrosinase-related protein (TYRP1), specifically expressed in melanocytes and melanoma cells. Flanvotumab acts function via natural killing-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). Flanvotumab has potent anti-tumor activity and good tolerance.

Cat. No.	Product Name	Target	Category

HY-122933

Kurarinol	Tyrosinase Apoptosis	Flavonoids Flavonones Phenols Polyphenols Classification of Application Fields Disease Research Fields Cardiovascular Disease Source classification Plants Leguminosae Sophora flavescens
Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive *tyrosinase* inhibitor, with IC₅₀ of 0.1 μM for mushroom tyrosinase.

HY-N3002

α-Arbutin 4-Hydroxyphenyl α-D-glucopyranoside	Tyrosinase	Phenols Monophenols Classification of Application Fields Disease Research Fields Metabolic Disease Cosmetic Research Source classification Plants Ericaceae
α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is emerging as popular and effective skin whiteners, acting as *tyrosinase* inhibitor.

HY-N10219

Dihydroaltenuene B	Tyrosinase Fungal	Phenols Monophenols Classification of Application Fields Disease Research Fields Infection Source classification Microorganisms
Dihydroaltenuene B is a potent mushroom tyrosinase inhibitor with an IC₅₀ of 38.33 µM. Dihydroaltenuene B shows the hydrogen bonding interactions between the 3-OH and 4’-OH and the His244, Met280 and Gly281 residues of tyrosinase.

HY-W015782

4-Ethylresorcinol	Others	Phenols Polyphenols Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Plants Umbelliferae Angelica sinensis (Oliv.) Diels
4-Ethylresorcinol, a derivative of resorcinol, can act as substrates of tyrosinase. 4-Ethylresorcinol possess hypopigmentary effects. 4-Ethylresorcinol attenuates mRNA and protein expression of tyrosinase-related protein (TRP)-2, and possessed antioxidative effect by inhibiting lipid peroxidation.

HY-W013571

4-Isopropylbenzoic acid	Fungal	Ketones, Aldehydes, Acids Infection Disease Research Fields Classification of Application Fields Source classification Plants other families Euphorbiaceae Bridelia retusa
4-Isopropylbenzoic acid, an aromatic monoterpenoid, is isolated from the stem bark of Bridelia retusa. 4-Isopropylbenzoic acid exhibits antifungal activities. 4-Isopropylbenzoic acid is also a reversible and uncompetitive inhibitor of mushroom tyrosinase.

HY-N2134

Mirificin Puerarin apioside	Tyrosinase	Flavonoids Isoflavones Phenols Polyphenols Classification of Application Fields Disease Research Fields Endocrinology Source classification Plants other families
Mirificin (Puerarin apioside) is a isoflavone in Puerariae Lobatae Radix. Mirificin inhibits tyrosinase (TYR) with an IC₅₀ of 12.66 μM.

HY-133680

β-Tocopherol	Tyrosinase	Phenols Monophenols Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Plants Palmae Trachycarpus fortunei (Hook.) H. Wendl.
β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit *tyrosinase* activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol.

HY-W019829

Polyphyllin C	Tyrosinase Parasite	Steroids Classification of Application Fields Disease Research Fields Infection Source classification Plants other families
Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC₅₀=36.87 µM) activities against the *tyrosinase* and moderate (IC₅₀=1.59 µg/mL) antileishmanial activities.

HY-N10286

Chetoseminudin B	Tyrosinase	Alkaloids Indole Alkaloids Classification of Application Fields Disease Research Fields Other Diseases Source classification Microorganisms
Chetoseminudin B possesses mushroom tyrosinase inhibitory activity with IC₅₀ of 31.7 μM.

HY-116750

6-Hydroxykaempferol	Others	Structural Classification Flavonols Flavonoids Leguminosae Trifolium repens Linn. Plants Source classification
6-Hydroxykaempferol, a flavonoid, is a competitive *tyrosinase* inhibitor with an IC₅₀ value of 124 μM. 6-Hydroxykaempferol has a K_i value of 148 μM relative to L-DOPA as a substrate and effectively inhibits the activity of the enzyme by binding to the active site of the enzyme.

HY-N10285

Phaeosphaone D	Tyrosinase	Alkaloids Indole Alkaloids Classification of Application Fields Disease Research Fields Infection Source classification Microorganisms
Phaeosphaone D is a thiodiketopiperazine alkaloid compound isolated from Phaeosphaeria fuckelii, an endophytic fungus. Phaeosphaone D displays mushroom tyrosinase inhibitory activity with an IC₅₀ value of 33.2 μM.

HY-N7135

Tropolone	Tyrosinase	Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Other Diseases Source classification Plants Olacaceae Olax imbricata
Tropolone, a tropone derivative with a hydroxyl group in the 2-position, is a precursor of manyazulene derivatives such as methyl 2-methylazulene-1-carboxylate. Tropolone is a potent inhibitor of mushroom tyrosinase with a IC₅₀ of 0.4 μM, and the inhibition can be reversed by dialysis or by excess CU²⁺.

HY-N0637A

(±)-Eriodictyol (±)-Huazhongilexone	Melanocortin Receptor	Structural Classification Flavones Flavonoids Source classification Plants Lythraceae Lawsonia inermis L.
(±)-Eriodictyol ((±)-Huazhongilexone), a flavonoid, is a potent melanogenesis inhibitor with an IC₅₀ of 48 μM. (±)-Eriodictyol suppresses tyrosinase, TRP-1, and TRP-2 mRNA expression. (±)-Eriodictyol has strong anti-plasmin activities.

HY-Y0444

D-Tyrosine	Tyrosinase	Phenols Monophenols Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Endogenous metabolite
D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting *tyrosinase* activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth.

HY-N1658

2,3-Dihydroisoginkgetin	Tyrosinase	Flavonoids Biflavones Phenols Polyphenols Classification of Application Fields Disease Research Fields Other Diseases Source classification Plants Podocarpaceae Podocarpus macrophyllus (Thunb.) Sweet
2,3-Dihydroisoginkgetin, a biflavonoid, is a inhibitor of *Tyrosinase, with 36.84% inhibition at 0.1 mM. 2,3-Dihydroisoginkgetin shows less toxicity in HEMn (human epidermal melanocytes) cells, with an IC₅₀* of 86.16 μM.

HY-134046

(-)-Isodocarpin Isodocarpin	Melanocortin Receptor	Source classification Plants Labiatae Isodon trichocarpus (Maxim.) Kudô
(-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC₅₀ of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA.

HY-N1780

3,4-Dimethoxyphenol	Tyrosinase	Monophenols Phenols Metabolic Disease Cosmetic Research Disease Research Fields Classification of Application Fields Source classification Microorganisms
3,4-Dimethoxyphenol is a plant-derived phenylpropanoid compound and can use as a whitening agent in cosmetics. 3,4-Dimethoxyphenol has *tyrosinase*-inhibiting activity. 3,4-Dimethoxyphenol has potent antioxidant effect isolated from the bacterial fermentation broth.

HY-B0856

Validamycin A	Fungal Tyrosinase Antibiotic	Antibiotics Other Antibiotics Infection Disease Research Fields Classification of Application Fields Source classification Microorganisms
Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL. Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC₅₀ of 72 μM. Validamycin A is a reversible *tyrosinase* inhibitor, with a K_i of 5.893 mM.

HY-N10503

Norartocarpetin	Tyrosinase Ras Raf MAPKAPK2 (MK2) Apoptosis	Flavones Structural Classification Flavonoids Plants Moraceae
Norartocarpetin is a *tyrosinase* inhibitor. Norartocarpetin has strong tyrosinase inhibitory activity with an IC₅₀ value of 0.47 μM. Norartocarpetin as an antibrowning agent can be used for the research of food systems. Norartocarpetin also has a significant anticancer activity in lung carcinoma cells (NCI-H460) with an IC₅₀ value of 22 μM. Norartocarpetin has antiproliferative effects are mediated via targeting Ras/Raf/MAPK signalling pathway, mitochondrial mediated apoptosis, S-phase cell cycle arrest and suppression of cell migration and invasion in human lung carcinoma cells.

HY-N1386

2-Methoxycinnamic acid	Tyrosinase	Phenylpropanoids Simple Phenylpropanols Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Plants Ranunculaceae Pulsatilla chinensis (Bunge) Regel
2-Methoxycinnamic acid is a noncompetitive inhibitor of *tyrosinase*.

HY-N6244

Isolindleyin	Tyrosinase	Phenols Polyphenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Polygonaceae Rheum officinale Baill.
Isolindleyin, a butyrophenone, is a *tyrosinase* inhibitor, with a K_d of 54.8 μM for human tyrosinase. Isolindleyin exhibits anti-inflammatory, analgesic and anti-melanogenic activities.

HY-N2278

Kushenol A Leachianone E	Tyrosinase Glucosidase	Flavonoids Flavonones Phenols Polyphenols Classification of Application Fields Disease Research Fields Cancer Source classification Plants Leguminosae Sophora flavescens
Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive *tyrosinase* inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC₅₀ and K_ivalues of 1.1 μM and 0.4 μM, respectively. Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC₅₀: 45 μM; K_i: 6.8 μM) and β-amylase. Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging.

HY-N3266

Methyl rosmarinate	Tyrosinase	Phenylpropanoids Phenols Polyphenols Simple Phenylpropanols Disease Research Fields Cancer Classification of Application Fields Source classification Plants Labiatae Baccharis darwinii Hook. & Arn.
Methyl rosmarinate is a noncompetitive *tyrosinase* inhibitor which is isolated from Rabdosia serra, with an IC₅₀ of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase.

HY-N2204

Swertiajaponin	Tyrosinase	Flavonoids Flavones Phenols Polyphenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants other families
Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC₅₀ of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity.

HY-N10623

5-epi-Arvestonate A	Tyrosinase	Sesquiterpenes Terpenoids
5-epi-Arvestonate A is a sesquiterpenoid isolated from the whole plants of Seriphidium transiliense. 5-epi-Arvestonate A promotes melanogenic production by activating the transcription of microphthalmia-associated transcription factor (MITF) and tyrosinase family genes. 5-epi-Arvestonate A inhibits the expression of IFN-γ-chemokine through the JAK/STAT signaling pathway in immortalized human keratinocyte (HaCaT) cells.

HY-N3748

Dihydromorin	Tyrosinase	Flavonoids Flavanonols Phenols Polyphenols Classification of Application Fields Disease Research Fields Cancer Source classification Plants other families
Dihydromorin, a natural flavanonol compound, is a *tyrosinase* inhibitor.

HY-N3200

Neorauflavane	Tyrosinase	Structural Classification Phenols Polyphenols Leguminosae Plants Source classification Campylotropis hirtella (Franch.) Schindl.
Neorauflavane is a potent *tyrosinase* inhibitor derived from Campylotropis hirtella, with an IC₅₀ value of 30 nM for tyrosinase monophenolase activity and an IC₅₀ value of 500 nM for diphenolase activity. Neorauflavane can effectively reduce the melanin content of B16 melanoma cells.

HY-W015967

Glycolic acid Hydroxyethanoic acid	Endogenous Metabolite Tyrosinase	Ketones, Aldehydes, Acids Structural Classification Nervous System Disorder Immune System Disorder Disease markers Cancer Endocrine diseases Endogenous metabolite Source classification Metabolic Disease Disease Research Fields Classification of Application Fields
Glycolic acid is an inhibitor of *tyrosinase*, suppressing melanin formation and lead to a lightening of skin colour.

HY-N2101

Benzoyloxypaeoniflorin	Tyrosinase NF-κB	Monophenols Terpenoids Phenols Other Monoterpenes Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Paeoniaceae Paeonia lactiflora Pall.
Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a *tyrosinase* inhibitor against mushroom tyrosinase with IC₅₀ of 0.453 mM. Benzoyloxypaeoniflorin is NF-κB Inhibitor and contributes to improving blood circulation through its inhibitory effect on both platelet aggregation and blood coagulation.

HY-N10287

Leptosin D	Tyrosinase	Alkaloids Indole Alkaloids Classification of Application Fields Disease Research Fields Infection Source classification Microorganisms
Leptosin D, a thiodiketopiperazine alkaloid, is a mushroom tyrosinase inhibitor, with an IC₅₀ of 28.4 μM.

HY-N3425

Kazinol U	AMPK	Flavonoids Flavanols Phenols Polyphenols Classification of Application Fields Disease Research Fields Other Diseases Source classification Plants other families
Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK activation.

HY-N7929

5-Feruloylquinic acid	Tyrosinase	Phenylpropanoids Other Phenylpropanoids Phenols Monophenols Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Cancer Source classification Plants other families
5-Feruloylquinic acid (5-FQA) possesses antioxidative effects and tyrosinase inhibitory activities.

HY-N11521

7-Methoxy obtusifolin	Tyrosinase	Quinones Anthraquinones Structural Classification Leguminosae Plants Source classification Cassia tora Linn.
7-Methoxy obtusifolin (Compound 4) is a competitive *tyrosinase* inhibitor with an IC₅₀ of 7.0 μM.

HY-N3101

Pedalitin	Endogenous Metabolite Tyrosinase Glucosidase	Flavonoids Flavones Phenols Polyphenols Classification of Application Fields Disease Research Fields Endocrinology Source classification Plants other families
Pedalitin is a inhibitor of tyrosinase（IC₅₀=0.28 mM） and α-glucosidase（IC₅₀=0.29 mM）.

HY-B1461

Deoxyarbutin	Tyrosinase	Phenols Monophenols Natural Products Classification of Application Fields Disease Research Fields Other Diseases Source classification Plants other families
Deoxyarbutin is a new effective lighten ingredient, can effectively inhibit tyrosinase activity and melanin synthesis to get significant and lasting lightening effect.

HY-N5118

Chimonanthine (-)-Chimonanthine	Tyrosinase	Alkaloids Alkaloid Dimers Classification of Application Fields Disease Research Fields Cancer Source classification Plants Calycanthaceae Chimonanthus nitens Oliv.
Chimonanthine is an alkaloid of Chimonanthus praecox, inhibits tyrosinase and tyrosine-related protein-1 mRNA expression, amd inhibits melanogenesis.

HY-N1430

Oxyresveratrol trans-Oxyresveratrol	Tyrosinase HSV Autophagy	Phenols Stilbenes Polyphenols Other Diseases Disease Research Fields Anti-aging Classification of Application Fields Source classification Plants other families
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC₅₀ of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive *tyrosinase* inhibitor with an IC₅₀ value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects.

HY-N8223

Viscumneoside III	Tyrosinase	Flavonoids Flavonones Phenols Polyphenols Classification of Application Fields Disease Research Fields Cardiovascular Disease Source classification Plants Loranthaceae Viscum coloratum (Kom.) Nakai
Viscumneoside III, a dihydroflavone O-glycoside, is a potent *tyrosinase* inhibitor with an IC₅₀ of 0.5 mM. Viscumneoside III has anti-angina pectoris.

HY-N3943

Glabrene	Tyrosinase	Stilbenes Phenols Polyphenols Source classification Plants Leguminosae Glycyrrhiza uralensis Fisch.
Glabrene, an isoflavene derived from licorice root, shows estrogen-like activity. Glabrene is a *tyrosinase* inhibitor with an IC₅₀ of 3.5 μM.

HY-126052

Gnetol	COX Tyrosinase HDAC	Phenols Stilbenes Polyphenols Structural Classification Gnetaceae Plants Source classification Gnetum montanum Markgr. Metabolic Disease Disease Research Fields Classification of Application Fields
Gnetol is a phenolic compound isolated from the root of Gnetum montanum . Gnetol potently inhibits COX-1 (IC₅₀ of 0.78 μM) and HDAC. Gnetol is a potent *tyrosinase* inhibitor with an IC₅₀ of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities.

HY-N3517

Oxyresveratrol 3'-O-β-D-glucopyranoside	Tyrosinase	Stilbenes Phenols Polyphenols Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Plants Polygonaceae Reynoutria japonica Houtt.
Oxyresveratrol 3'-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective *tyrosinase* inhibitor with an IC₅₀ of 1.64 μM.

HY-N3516

Oxyresveratrol 2-O-β-D-glucopyranoside	Tyrosinase	Stilbenes Phenols Polyphenols Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Plants Moraceae Morus alba Linn.
Oxyresveratrol 2-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective *tyrosinase* inhibitor with an IC₅₀ of 29.75 μM.

HY-N3773

Dodoviscin A	Tyrosinase	Structural Classification Flavones Flavonoids Sapindaceae Dodonaea viscosa (L.) Jacq. Plants Source classification
Dodoviscin A is a pigmentation-altering agent, which can be isolated from the aerial parts of Dodonaea viscosa. Dodoviscin A inhibits melanin production in B16-F10 melanoma cells. Dodoviscin A suppresses mushroom tyrosinase activity, and tyrosinase activity induced by 3-isobutyl-1-methylxanthine. Dodoviscin A also inhibits the phorphosylation of cAMP response element binding protein, induced by 3-isobutyl-1-methylxanthine and forskolin.

HY-N2460

Aloesin Aloeresin	Tyrosinase Apoptosis	Ketones, Aldehydes, Acids Monophenols Phenols Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Liliaceae Aloe vera (Linn.) N. L. Burman var. chinensis (Haw.) Berg.
Aloesin (Aloeresin) is a *tyrosinase* inhibitor, and shows anti-inflammatory activity, ultraviolet protection, and antibacterium effects. Aloesin can induce apoptosis and be used in ovarian cancer research.

HY-N3912

Furomollugin	Bacterial	Natural Products Source classification Plants Rubiaceae Rubia podantha
Furomollugin is a natural product with antioxidant and antibacterial activities, can be isolated from Rubia cordifolia. Furomollugin lacks potent anti-tyrosinase activity, but also exhibits significant anticancer property.

HY-N3674

Dalbergioidin	TGF-beta/Smad	Structural Classification Phenols Polyphenols Phaseolus vulgaris Linn. Leguminosae Plants Source classification
Dalbergioidin, a well-known anthocyanin, ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-β signal pathway. Dalbergioidin exhibits tyrosinase inhibitory activity with an IC₅₀ of 20 mM.

HY-N1481

Methyl linoleate	Others	Natural Products Metabolic Disease Disease Research Fields Classification of Application Fields Source classification Plants other families
Methyl linoleate, a major active constituent of Sageretia thea fruit (HFSF), is a major anti-melanogenic compound. Methyl linoleate downregulates microphthalmia-associated transcription factor (MITF) and tyrosinase-related proteins.

HY-N1750

3-(2,4-Dihydroxyphenyl)propanoic acid	Tyrosinase Endogenous Metabolite	Phenols Polyphenols Natural Products Other Diseases Disease Research Fields Classification of Application Fields Source classification Plants Moraceae Ficus carica L.
3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) is a potent and competitive *tyrosinase* inhibitor, inhibits L-Tyrosine and DL-DOPA with an IC₅₀ and a K_i of 3.02 μM and 11.5 μM, respectively.

HY-N0616

Trifolirhizin	Tyrosinase	Other Flavonoids Flavonoids Inflammation/Immunology Disease Research Fields Cancer Classification of Application Fields Source classification Plants Leguminosae Trifolium pratense Linn. Sophora flavescens
Trifolirhizin is a pterocarpan flavonoid isolated from the roots of Sophora flavescens. Trifolirhizin possesses potent *tyrosinase* inhibitory activity with an IC₅₀ of 506 μM. Trifolirhizin exhibits potential anti-inflammatory and anticancer activities.

HY-N11063

Obtusifolin-2-O-glucoside	Tyrosinase	Quinones Anthraquinones Structural Classification Monophenols Phenols Leguminosae Plants Source classification Cassia tora Linn.
Obtusifolin-2-O-glucoside (compound 7) is a *Tyrosinase* inhibitor (IC₅₀=9.2 μM). Obtusifolin-2-O-glucoside can be isolated from cassia seed.

HY-N10437

6-Acetylnimbandiol 6-O-Acetylnimbandiol	Tyrosinase	Terpenoids Structural Classification Diterpenoids Azadirachta indica A. Juss. Meliaceae Plants Source classification
6-Acetylnimbandiol (6-O-Acetylnimbandiol) is a non-cytotoxic *tyrosinase* inhibitor (IC₅₀=69.85 μM) that effectively inhibits melanin production and MITF expression. 6-Acetylnimbandiol can be used in melanoma research.

HY-N0136

Taxifolin (+)-Dihydroquercetin; (+)-Taxifolin	Autophagy Tyrosinase	Flavonoids Flavanonols Phenols Polyphenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Anti-aging Source classification Plants other families
Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.

HY-N3518

Mulberroside F	Tyrosinase	Phenols Monophenols Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Plants other families
Mulberroside F is one of the main bioactive constituents in mulberry (Morus alba L.). Mulberroside F shows inhibitory effects on *tyrosinase* activity and on the melanin formation. Mulberroside F also exhibits superoxide scavenging activity that is involved in the protection against auto-oxidation.

HY-W013636

2-Ketoglutaric acid Alpha-Ketoglutaric acid	Tyrosinase Endogenous Metabolite	Ketones, Aldehydes, Acids Structural Classification Nervous System Disorder Immune System Disorder Endocrine diseases Endogenous metabolite Disease markers Source classification Other Diseases Disease Research Fields Anti-aging Classification of Application Fields
2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of *tyrosinase* (IC₅₀=15 mM).

HY-N2472

Medicagenic acid Castanogenin	Bacterial	Triterpenes Terpenoids Structural Classification Caryophyllaceae Herniaria glabra Linnaeus. Plants Infection Disease Research Fields Classification of Application Fields
Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes. Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE.

HY-W013636B

Calcium 2-oxoglutarate	Tyrosinase Endogenous Metabolite	Ketones, Aldehydes, Acids Structural Classification Endogenous metabolite Source classification Metabolic Disease Disease Research Fields Classification of Application Fields
Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of *tyrosinase* (IC₅₀=15 mM).

HY-W013636A

2-Ketoglutaric acid Sodium Alpha-Ketoglutaric acid Sodium	Tyrosinase Endogenous Metabolite	Ketones, Aldehydes, Acids Structural Classification Endogenous metabolite Source classification Metabolic Disease Disease Research Fields Classification of Application Fields
2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of *tyrosinase* (IC₅₀=15 mM).

HY-N0136A

(±)-Taxifolin (±)-Dihydroquercetin	Autophagy Tyrosinase	Flavonoids Flavanonols Phenols Polyphenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants other families
(±)-Taxifolin ((±)-Dihydroquercetin) is the racemate of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.

HY-N1775

3',4'-Dihydroxyacetophenone 3,4-DHAP	Tyrosinase	Phenols Polyphenols Classification of Application Fields Disease Research Fields Cancer Source classification Plants Pinaceae Picea schrenkiana Fisch. et Mey.
3',4'-Dihydroxyacetophenone (3,4-DHAP), isolated from Picea Schrenkiana Needles exhibits a strong suppressive action against *tyrosinase* activity, with an IC₅₀ of 10 μM. 3',4'-Dihydroxyacetophenone (3,4-DHAP) is a vasoactive agent and antioxidant.

HY-N0136B

(-)-Taxifolin (-)-Dihydroquercetin	Tyrosinase	Flavonoids Flavanonols Phenols Polyphenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants other families
(-)-Taxifolin is the less active enantiomer of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.

HY-N4005

Isoastilbin	Bacterial Tyrosinase	Phenols Flavanonols Polyphenols Flavonoids Source classification Plants other families
Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC₅₀ value of 54.3 μg/mL, and also inhibits *tyrosinase* activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research.

HY-N0192

Arbutin β-Arbutin	Tyrosinase Endogenous Metabolite	Phenols Disease Research Fields Cancer Classification of Application Fields Source classification Plants Saxifragaceae Bergenia purpurascens (Hook. f. et Thoms.) Engl.
Arbutin (β-Arbutin) is a competitive inhibitor of *tyrosinase, with K_i^app* values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties.

HY-113068

(rel)-β-Tocopherol	Tyrosinase	Structural Classification Monophenols Phenols
(rel)-β-Tocopherol is a relative configuration of β-Tocopherol.(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol.

HY-N0445

2-Hydroxy-4-methoxybenzaldehyde	Tyrosinase Bacterial	Phenylpropanoids Monophenols Phenols Simple Phenylpropanols Other Diseases Disease Research Fields Classification of Application Fields Source classification Plants other families
2-Hydroxy-4-methoxybenzaldehyde, a chemical compound and an isomer of Vanillin, could be used to synthesis Urolithin M7. 2-hydroxy-4-methoxybenzaldehyde is a potent *tyrosinase* inhibitor from three East African medicinal plants, Mondia whitei, Rhus vulgaris Meikle, and Sclerocarya caffra Sond.

HY-W017212

Methyl cinnamate Methyl 3-phenylpropenoate	Tyrosinase Bacterial AMPK	Phenylpropanoids Simple Phenylpropanols Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Plants Rutaceae Zanthoxylum armatum DC.
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a *tyrosinase* inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway.

HY-N0619

Mulberroside A	TNF Receptor Interleukin Related Tyrosinase	Phenols Stilbenes Polyphenols Structural Classification Morus alba L. Plants Source classification Moraceae Inflammation/Immunology Disease Research Fields Classification of Application Fields
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.). Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects. Mulberroside A shows inhibitory activity against mushroom *tyrosinase* with an IC₅₀ of 53.6 μM.

HY-N2983

Cajanin	Others	Flavonoids Isoflavones Phenols Polyphenols Classification of Application Fields Disease Research Fields Other Diseases Source classification Plants Leguminosae red seaweeds
Cajanin is a potent and orally active anti-melanogenic agent. Cajanin shows antiproliferative activity in MNT1 Cells. Cajanin efficiently decreases the melanin content. Cajanin down-regulates the mRNA and protein expression levels of MITF, tyrosinase, TRP-1 and Dct (TRP-2). Cajanin induces cell cycle arrest at G2/M and S phase. Cajanin stimulates osteoblast proliferation. Cajanin has the potential for the research of human hyperpigmented disorders and menopausal osteoporosis.

HY-N0619A

cis-Mulberroside A Mulberroside D	TNF Receptor Interleukin Related Tyrosinase	Phenols Stilbenes Polyphenols Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Moraceae Morus alba Linn.
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.). Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects. Mulberroside A shows inhibitory activity against mushroom *tyrosinase* with an IC₅₀ of 53.6 μM.

Species:	Human (2) Mouse (1)
Tag:	His (3) SUMO (2)
Source:	P. pastoris (1) E. coli (2)

Cat. No.	Product Name	Species	Source

HY-P71792

TYR Protein, Human (P.pastoris, His) ATN; CMM8; LB24 AB; LB24-AB; OCA1; OCA1A; OCAIA; Oculocutaneous albinism IA; SHEP3; SK29 AB; SK29-AB; Tumor rejection antigen AB; TYR; tyrosinase	Human	P. pastoris

HY-P72168

DCT Protein, Human (His-SUMO) L dopachrome tautomerase; DCT; Dopachrome delta isomerase; Dopachrome tautomerase; Dopachrome tautomerase dopachrome delta isomerase; tyrosine related protein 2; DT; EC 5.3.3.12; L dopachrome Delta isomerase; L-dopachrome Delta-isomerase; L-dopachrome tautomerase; TRP 2; TRP-2; TRP2; tyrosinase related protein 2; tyrosinase-related protein 2; TYRP2; TYRP2_HUMAN	Human	E. coli

HY-P72169

DCT Protein, Mouse (His-SUMO) Dct; Tyrp-2; Tyrp2; L-dopachrome tautomerase; DCT; DT; EC 5.3.3.12; DOPAchrome conversion factor; DOPAchrome isomerase; DOPAchrome oxidoreductase; L-dopachrome Delta-isomerase; SLATY locus protein; tyrosinase-related protein 2; TRP-2; TRP2	Mouse	E. coli

Cat. No.	Product Name

HY-W015967S

Glycolic acid-d2

Glycolic acid-d₂ is the deuterium labeled Glycolic acid. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

HY-Y0444S

D-Tyrosine-d2
D-Tyrosine-d₂ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-Y0444S1

D-Tyrosine-d4
D-Tyrosine-d₄ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-Y0444S2

D-Tyrosine-d7
D-Tyrosine-d₇ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-N0136S

Taxifolin-d3
Taxifolin-d₃ is deuterium labeled Taxifolin. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].

HY-113068S

β-Tocopherol-d3
β-Tocopherol-d₃ is the deuterium labeled β-Tocopherol. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol can also prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol[1][2][3].

HY-W013636S1

2-Ketoglutaric acid-d4
2-Ketoglutaric acid-d₄ is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

HY-N0192S

Arbutin-d4

Arbutin-d₄ is deuterium labeled Arbutin. Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents[1]. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[2][3].

HY-W013636S2

2-Ketoglutaric acid-d6
2-Ketoglutaric acid-d₆ is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

HY-W013636S

2-Ketoglutaric acid-13C5
2-Ketoglutaric acid-¹³C₅ is the ¹³C labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

tyrosinase

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