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Results for "

tyrosinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Tyrosinase (113) AMPK (2) Apoptosis (3) Autophagy (5) Bacterial (7) Biochemical Assay Reagents (1) COX (1) DNA/RNA Synthesis (1) Elastase (1) Endogenous Metabolite (13) ERK (1) Fungal (3) Glucosidase (2) HDAC (1) HSV (1) Interleukin Related (2) Isotope-Labeled Compounds (7) MAPKAPK2 (MK2) (1) Melanocortin Receptor (4) NF-κB (1) Parasite (1) Phosphatase (1) PPAR (1) Raf (1) Ras (1) Reactive Oxygen Species (2) Sirtuin (1) TGF-beta/Smad (1) TNF Receptor (2)
By Research Areas:	Cancer (49) Cardiovascular Disease (2) Endocrinology (4) Infection (11) Inflammation/Immunology (18) Metabolic Disease (24) Neurological Disease (2)

By Targets:

Tyrosinase (113)

AMPK (2)

Apoptosis (3)

Autophagy (5)

Bacterial (7)

Biochemical Assay Reagents (1)

COX (1)

DNA/RNA Synthesis (1)

Elastase (1)

Endogenous Metabolite (13)

ERK (1)

Fungal (3)

Glucosidase (2)

HDAC (1)

HSV (1)

Interleukin Related (2)

Isotope-Labeled Compounds (7)

MAPKAPK2 (MK2) (1)

Melanocortin Receptor (4)

NF-κB (1)

Parasite (1)

Phosphatase (1)

PPAR (1)

Raf (1)

Ras (1)

Reactive Oxygen Species (2)

Sirtuin (1)

TGF-beta/Smad (1)

TNF Receptor (2)

By Research Areas:

Cancer (49)

Cardiovascular Disease (2)

Endocrinology (4)

Infection (11)

Inflammation/Immunology (18)

Metabolic Disease (24)

Neurological Disease (2)

140

Inhibitors & Agonists

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Tyrosinase-IN-18	Tyrosinase	Others
Tyrosinase-IN-18 (compound 6) is a potent tyrosinase inhibitor. Tyrosinase-IN-18 has strong antioxidant activities against ROS, ABTS+, and DPPH radicals .

Tyrosinase-IN-19	Tyrosinase	Metabolic Disease
Tyrosinase-IN-19 (compound 9) is a competitive *tyrosinase* inhibitor. Tyrosinase-IN-19 has strong antioxidant activities against ROS, ABTS+, and DPPH radicals. Tyrosinase-IN-19 suppresses tyrosinase expression in a dose-dependent manner .

Tyrosinase-IN-24	Tyrosinase	Cancer
Tyrosinase-IN-24 (compound 3b) is a tyrosinase inhibitor with inhibitory activity against mushroom tyrosinase .

Tyrosinase-IN-15	Tyrosinase	Cancer
Tyrosinase-IN-15 (Compound 39) is a *tyrosinase* inhibitor (IC₅₀: 7.12 μM, K_i: 11.8 μM) .

Tyrosinase-IN-5	Tyrosinase	Cancer
Tyrosinase-IN-5 (compound 16c) is a potent inhibitor of *tyrosinase* with an IC₅₀ of 0.02 μM. Tyrosinase-IN-5 efficiently suppresses the melanogenesis without significant toxicity on cells .

Tyrosinase-IN-23	Tyrosinase	Cancer
Tyrosinase-IN-23 (Compd 11m) is a *tyrosinase* inhibitor with an IC₅₀ of 55.39±4.93 µM. Tyrosinase-IN-23 can be used for research of melanin biosynthesis .

Tyrosinase-IN-20	Tyrosinase	Cancer
Tyrosinase-IN-20 (compound 6a) is a potent inhibitor of *Tyrosinase* with an IC₅₀ of 28.50 μM .

Tyrosinase-IN-21	Tyrosinase	Others
Tyrosinase-in-21 (compound 3g) is a *tyrosinase* inhibitor with IC₅₀ value of 80.93 μM .

Tyrosinase-IN-11	Tyrosinase	Metabolic Disease
Tyrosinase-IN-11 is a potent *tyrosinase* inhibitor with IC₅₀s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research .

Tyrosinase-IN-14	Tyrosinase	Others
Tyrosinase-IN-14 (compound 7m) is a tyrosinase inhibitor that reduces the catalytic activity of tyrosinase by changing its secondary structure. Tyrosinase-IN-14 has low cytotoxicity and anti-browning activity in fruits. Tyrosinase-IN-14 effectively inhibits banana browning during storage .

Tyrosinase (206-214), human	Tyrosinase	Inflammation/Immunology Cancer
Tyrosinase (206-214), human (AFLPWHRLF), a 9-amino acid peptide, is a tyrosinase epitope. Tyrosinase (206-214), human can be recognized by HLA-A24 restricted, tumor-infiltrating lymphocytes (TIL) .

Tyrosinase-IN-22 5-Chloro-2-mercaptobenzimidazole	Reactive Oxygen Species Tyrosinase	Cancer
Tyrosinase-IN-22 (compound 4) is an inhibitor of tyrosinase substrates (L-tyrosine and L-dopa) with IC₅₀s of 60 nM and 30 nM, respectively. Tyrosinase-IN-22 also shows potent antioxidant and anti-melanogenic properties, thus can be used for relevant researches .

Tyrosinase-IN-3	Tyrosinase	Others
Tyrosinase-IN-3 (compound 54) is a potent inhibitor of *tyrosinase. Tyrosinase* is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-3 has the potential for the research of skin whitening agents and food preservatives .

Tyrosinase-IN-4	Tyrosinase	Others
Tyrosinase-IN-4 (compound 34) is a potent inhibitor of *tyrosinase. Tyrosinase* is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-4 has the potential for the research of skin whitening agents and food preservatives .

Tyrosinase-IN-1	Tyrosinase	Others
Tyrosinase-IN-1 (compound 90) is a potent inhibitor of *tyrosinase. Tyrosinase* is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-1 has the potential for the research of skin whitening agents and food preservatives .

Tyrosinase-IN-2	Tyrosinase	Others
Tyrosinase-IN-2 (compound 67) is a potent inhibitor of *tyrosinase. Tyrosinase* is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-2 has the potential for the research of skin whitening agents and food preservatives .

Tyrosinase-IN-13	Tyrosinase	Cancer
Tyrosinase-IN-13 (compound 3c), a derivative of Flurbiprofen (HY-10582), is a potent, non-competitive tyrosinase inhibitor (IC₅₀=68 μM; Ki=36.3 μM). Tyrosinase-IN-13 is cytotoxic against hepatocellular carcinoma (HepG2), colorectal cancer (HT-29), and melanoma (B16F10) .

Tyrosinase-IN-12	Reactive Oxygen Species Tyrosinase	Others
Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) is a potent, non-competitive *tyrosinase* inhibitor with an IC₅₀ value of 49.33 ± 2.64 µM and K_i value of 31.25 ± 0.25 µM. Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) have the highest radical scavenging activity to reduce the production of reactive oxygen species (ROS) with an IC₅₀ value of 25.39 ± 0.77 µM. Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) can be used for anti-browning substances in the food and agricultural sectors .

Tyrosinase-IN-8	Tyrosinase	Cancer
Tyrosinase-IN-8 is a potent *tyrosinase* inhibitor with an IC₅₀ value of 1.6 µM. Tyrosinase-IN-8 inhibits cell growth with low cytotoxicity .

Tyrosinase-IN-7	Tyrosinase	Cancer
Tyrosinase-IN-7 is a potent *tyrosinase* inhibitor with an IC₅₀ value of 1.57 µM. Tyrosinase-IN-7 inhibits cell growth with low cytotoxicity .

Tyrosinase-IN-26	Tyrosinase	Cancer
Tyrosinase-IN-26 (compound 13) is a uncompetitive *tyrosinase* inhibitor with the an IC₅₀ value of 68.86 µM. Tyrosinase-IN-26 can suppresses melanogenesis .

Tyrosinase-IN-10	Tyrosinase	Cancer
Tyrosinase-IN-10 (Compound 23) is a partially competitive *tyrosinase* inhibitor with an IC₅₀ of 1.6 μM against tyrosinase activity from human melanoma cell lysates .

Tyrosinase-IN-16	Tyrosinase	Cancer
Tyrosinase-IN-16 (compound 19a) is a tyrosine kinase (Tyrosinase) inhibitor with Ki=470 nM. Tyrosinase-IN-16 is cytotoxic to B16F10 cells, with >90% inhibition at 20 μM .

Tyrosinase-IN-25	Tyrosinase	Cancer
Tyrosinase-IN-25 (compound 1l) is an inhibitor of tyrosinase and melanin biosynthesis in human melanoma cells .

Tyrosinase-IN-17	Tyrosinase	Cancer
Tyrosinase-IN-17 (Compound 5b) is a lipophilic, skin-permeable, and non-cytotoxic *Tyrosinase* inhibitor (pIC₅₀=4.99). Tyrosinase-IN-17 can be used for research on melanin-related diseases, such as melanoma, melanogenesis, etc .

Tyrosinase/elastase-IN-1	Elastase	Others
Tyrosinase/elastase-IN-1 a triterpenoid from Rubus fraxinifolius leaves, has tyrosinase and elastase inhibitory activities.

Tyrosinase, Mushroom Polyphenol oxidase	Tyrosinase	Metabolic Disease
Tyrosinase (EC 1.14.18.1) (Polyphenol oxidase) is a rate-limiting enzyme that controls the production of melanin and is encoded by TYR gene. Tyrosinase is mainly found in melanosomes synthesized by skin melanocytes .

Tyrosinase-IN-6	Tyrosinase	Others
Compound 4B proved to be the most effective tyrosinase inhibitor (ic₅₀= 3.80 μ M) It also showed good antioxidant activity.

Kurarinol	Tyrosinase Apoptosis	Cardiovascular Disease Cancer
Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive *tyrosinase* inhibitor, with IC₅₀ of 0.1 μM for mushroom tyrosinase .

Persiconin	Tyrosinase	Others
Persiconin is a tyrosinase Inhibitor. Persiconin can be isolated from Prunus persica. Persiconin has tyrosinase inhibitory activity of 46% at 500 μM. Persiconin can be used in whitening research .

α-Arbutin 4-Hydroxyphenyl α-D-glucopyranoside	Tyrosinase	Metabolic Disease
α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is emerging as popular and effective skin whiteners, acting as *tyrosinase* inhibitor .

Litchinol B	Tyrosinase	Cancer
Litchinol B (compound 2) is a non-competitive tyrosinase inhibitor with an inhibition constant of 5.70 μM .

4-Ethylresorcinol	Tyrosinase	Metabolic Disease
4-Ethylresorcinol, a derivative of resorcinol, can act as substrates of tyrosinase. 4-Ethylresorcinol possess hypopigmentary effects. 4-Ethylresorcinol attenuates mRNA and protein expression of tyrosinase-related protein (TRP)-2, and possessed antioxidative effect by inhibiting lipid peroxidation .

Tetrapeptide-30	Tyrosinase	Inflammation/Immunology
Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation .

Dihydroaltenuene B	Tyrosinase Fungal	Infection
Dihydroaltenuene B is a potent mushroom tyrosinase inhibitor with an IC₅₀ of 38.33 µM. Dihydroaltenuene B shows the hydrogen bonding interactions between the 3-OH and 4’-OH and the His244, Met280 and Gly281 residues of tyrosinase .

Mirificin Puerarin apioside	Tyrosinase	Endocrinology
Mirificin (Puerarin apioside) is a isoflavone in Puerariae Lobatae Radix. Mirificin inhibits tyrosinase (TYR) with an IC₅₀ of 12.66 μM .

β-Tocopherol	Tyrosinase	Metabolic Disease
β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit *tyrosinase* activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

Chetoseminudin B	Tyrosinase	Others
Chetoseminudin B possesses mushroom tyrosinase inhibitory activity with IC₅₀ of 31.7 μM .

Decapeptide-12	Tyrosinase Sirtuin	Inflammation/Immunology Endocrinology
Decapeptide-12, a small oligopeptide, is a *tyrosinase* inhibitor that interacts with C-terminal residue of tyrosinase (K_d: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC₅₀: 40 µM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .

Polyphyllin C	Tyrosinase Parasite	Infection
Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC₅₀=36.87 µM) activities against the *tyrosinase* and moderate (IC₅₀=1.59 µg/mL) antileishmanial activities .

6-Hydroxykaempferol	Tyrosinase	Others
6-Hydroxykaempferol, a flavonoid, is a competitive *tyrosinase* inhibitor with an IC₅₀ value of 124 μM. 6-Hydroxykaempferol has a K_i value of 148 μM relative to L-DOPA as a substrate and effectively inhibits the activity of the enzyme by binding to the active site of the enzyme .

Phaeosphaone D	Tyrosinase	Infection
Phaeosphaone D is a thiodiketopiperazine alkaloid compound isolated from Phaeosphaeria fuckelii, an endophytic fungus. Phaeosphaone D displays mushroom tyrosinase inhibitory activity with an IC₅₀ value of 33.2 μM .

Broussonin C	Tyrosinase	Inflammation/Immunology
Broussonin C is a competitive inhibitor of *Tyrosinase* that can be isolated from Broussonetia kazinoki. Broussonin C inhibits monophenolase and diphenolase with IC₅₀s of 0.43 and 0.57 μM, respectively .

Tropolone	Tyrosinase	Others
Tropolone is a Tropone derivative with a hydroxyl group at the 2-position, and is the precursor of many Azulene derivatives, such as 2-methylazulene-1-carboxylate. Tropolone is a potent mushroom tyrosinase inhibitor with an IC₅₀ of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU ²⁺ Reversal .

(±)-Eriodictyol (±)-Huazhongilexone; Dihydroluteolin	Melanocortin Receptor	Metabolic Disease
(±)-Eriodictyol ((±)-Huazhongilexone), a flavonoid, is a potent melanogenesis inhibitor with an IC₅₀ of 48 μM. (±)-Eriodictyol suppresses tyrosinase, TRP-1, and TRP-2 mRNA expression. (±)-Eriodictyol has strong anti-plasmin activities .

3,4-Dihydroxybenzylamine hydrobromide 1 Publications Verification NSC 263475 hydrobromide	DNA/RNA Synthesis	Cancer
3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) is an improved dopamine analog cytotoxic and inhibits DNA polymerase activity in melanoma cells . 3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity .

Cat. No.	Product Name	Type

HY-D1840

Tyramide Amplification Buffer

Dyes

Tyramide Amplification Buffer is a ready-to-use buffer primarily intended for immunostaining of cells and tissues by the technique of tyramide signal amplification (TSA). TSA Technology is based on a tyrosinase labeling system that reacts a tyrosine-labeled antibody with a fluorescently labeled tyramide using peroxidase to form a highly amplified fluorescent signal. For example, horseradish peroxidase (HRP) can catalyze the reaction of tyrosine and hydrogen peroxide under milder conditions to generate epoxy groups. Epoxy groups promote the binding of tyramide to adjacent amino acids to form fluorescently labeled products .

Cat. No.	Product Name	Target	Research Area

HY-P3813

Tyrosinase (206-214), human	Tyrosinase	Inflammation/Immunology Cancer
Tyrosinase (206-214), human (AFLPWHRLF), a 9-amino acid peptide, is a tyrosinase epitope. Tyrosinase (206-214), human can be recognized by HLA-A24 restricted, tumor-infiltrating lymphocytes (TIL) .

HY-P2527

Tyrosinase-related Protein 2 (TRP-2) (181-188)	Peptides	Inflammation/Immunology
Tyrosinase-related Protein 2 (TRP-2) (181-188) is a tyrosinase-related protein 2 (TRP-2)-derived peptide, corresponding to residues 180-188. Tyrosinase-related Protein 2 (TRP-2) (181-188) is the major reactive epitope within TRP-2 recognized by anti-B16 CTLs. Tyrosinase-related Protein 2 (TRP-2) (181-188) is a peptide conforming to the MHC class I H2-Kb binding motif .

HY-P3452

Tetrapeptide-30	Tyrosinase	Inflammation/Immunology
Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation .

HY-P3742

Tyrosinase (192-200), human mouse	Peptides	Cancer
Tyrosinase (192-200), human mouse is a nonapeptide. Tyrosinase (192-200), human mouse can be recognized by cytolytic T cell (CTL) on the HLA-B44 molecule. Tyrosinase (192-200), human mouse can be used in research of melanoma associated cancers .

HY-P1919

*[Asp371]-Tyrosinase* (369-377), human**	Peptides	Cancer
Tyrosinase 369-377, human is a HLA-A2.1-restricted epitope derived from tyrosinase, has been used to develop tumor-targeted vaccines with mixed efficacy .

HY-P0096

Decapeptide-12	Tyrosinase Sirtuin	Inflammation/Immunology Endocrinology
Decapeptide-12, a small oligopeptide, is a *tyrosinase* inhibitor that interacts with C-terminal residue of tyrosinase (K_d: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC₅₀: 40 µM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .

HY-P4497

Prolylserine	ERK	Cancer
Prolylserine, a dipeptide, is an inhibitor of melanogenesis production in Mel-Ab cells. Prolylserine decreases expression of microphthalmia-associated transcription factor (MITF) and *tyrosinase, induces phorphosylation of ERK, but not cAMP response element binding protein (CREB)* .

HY-P3639

SYLQDSVPDSFQD

Peptides Others

SYLQDSVPDSFQD, anchor-modified for high-affinity binding to DR4, is a DR4-restricted MHC class II peptide Tyrosinase .
HY-P5251

Oligopeptide-68

Peptides Metabolic Disease

Oligopeptide-68 is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .

HY-P1827

mTRP-2 (180-188)	Peptides	Cancer
mTRP-2 (180-188) is a murine tyrosinase-related protein 2 (TRP-2) -derived peptide, corresponding to residues 180-188. TRP-2 (180-188) is identified as the major reactive epitope within TRP-2 recognized by anti-B16 CTLs .

HY-P3662

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2	Tyrosinase	Cancer
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates *tyrosinase* and exhibits thermoregulatory effect in rats model .

HY-P3645

(Nle4)-α-MSH	Melanocortin Receptor	Others
(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment .

Cat. No.	Product Name	Target	Research Area

HY-P99622

Flanvotumab IMC-20D7S	Tyrosinase	Cancer
Flanvotumab (IMC-20D7S) is a human monoclonal antibody targeting to tyrosinase-related protein (TYRP1), specifically expressed in melanocytes and melanoma cells. Flanvotumab acts function via natural killing-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). Flanvotumab has potent anti-tumor activity and good tolerance .

Species:	Human (2) Mouse (2)
Tag:	His (4) SUMO (2)
Source:	E. coli Cell-free (1) P. pastoris (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P71792

	TYR Protein, Human (P.pastoris, His) ATN; CMM8; LB24 AB; LB24-AB; OCA1; OCA1A; OCAIA; Oculocutaneous albinism IA; SHEP3; SK29 AB; SK29-AB; Tumor rejection antigen AB; TYR; tyrosinase	Human	P. pastoris
	TYR protein, a copper-containing oxidase, initiates melanin production by catalyzing the hydroxylation of tyrosine to DOPA. This essential step is rate-limiting in the synthesis of melanins and polyphenolic compounds. TYR further enables the oxidation of DOPA to DOPA-quinone and potentially mediates the conversion of DHI to indole-5,6 quinone, playing a crucial role in the intricate cascade of reactions involved in melanin biosynthesis. TYR Protein, Human (P.pastoris, His) is the recombinant human-derived TYR protein, expressed by P. pastoris , with N-His, N-6*His labeled tag. The total length of TYR Protein, Human (P.pastoris, His) is 359 a.a., with molecular weight of ~48 kDa.

HY-P702479

TYR/Tyrosinase Protein, Mouse (Cell-Free, His)

tyrosinase; Albino locus protein; Monophenol monooxygenase
Mouse E. coli Cell-free

HY-P72168

	DCT Protein, Human (His-SUMO) L dopachrome tautomerase; DCT; Dopachrome delta isomerase; Dopachrome tautomerase; Dopachrome tautomerase dopachrome delta isomerase; tyrosine related protein 2; DT; EC 5.3.3.12; L dopachrome Delta isomerase; L-dopachrome Delta-isomerase; L-dopachrome tautomerase; TRP 2; TRP-2; TRP2; tyrosinase related protein 2; tyrosinase-related protein 2; TYRP2; TYRP2_HUMAN	Human	E. coli
	DCT Protein is essential in melanin biosynthesis, catalyzing the conversion of L-dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA), a pivotal step in melanin synthesis. DCT Protein, Human (His-SUMO) is the recombinant human-derived DCT protein, expressed by E. coli , with N-SUMO, N-10*His labeled tag. The total length of DCT Protein, Human (His-SUMO) is 449 a.a., with molecular weight of ~71.3 kDa.

HY-P72169

	DCT Protein, Mouse (His-SUMO) Dct; Tyrp-2; Tyrp2; L-dopachrome tautomerase; DCT; DT; EC 5.3.3.12; DOPAchrome conversion factor; DOPAchrome isomerase; DOPAchrome oxidoreductase; L-dopachrome Delta-isomerase; SLATY locus protein; tyrosinase-related protein 2; TRP-2; TRP2	Mouse	E. coli
	DCT (Dopachrome tautomerase) is pivotal in melanin biosynthesis, catalyzing the conversion of L-dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA), a critical step in melanin synthesis. DCT's enzymatic activity is integral to the complex processes governing melanin production, emphasizing its role in skin pigmentation and the regulation of melanin-related functions. DCT Protein, Mouse (His-SUMO) is the recombinant mouse-derived DCT protein, expressed by E. coli , with N-10*His, N-SUMO labeled tag. The total length of DCT Protein, Mouse (His-SUMO) is 449 a.a., with molecular weight of ~69.7 kDa.

Cat. No.	Product Name	Chemical Structure

HY-W015967S

Glycolic acid-d2
Glycolic acid-d₂ is the deuterium labeled Glycolic acid. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

HY-Y0444S1

D-Tyrosine-d4
D-Tyrosine-d₄ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-W778203

Glycolic acid-13C2
Glycolic acid- ¹³C₂ is the ¹³C-labeled Glycolic acid (HY-W015967). Glycolic acid- ¹³C₂ is an inhibitor of *tyrosinase*, suppressing melanin formation and lead to a lightening of skin colour.

HY-Y0444S

D-Tyrosine-d2
D-Tyrosine-d₂ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-Y0444S2

D-Tyrosine-d7
D-Tyrosine-d₇ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-N0136S

Taxifolin-d3
Taxifolin-d₃ is deuterium labeled Taxifolin. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].

HY-113068S

β-Tocopherol-d3
β-Tocopherol-d₃ is the deuterium labeled β-Tocopherol. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol can also prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol[1][2][3].

HY-N0192S

Arbutin-d4

Arbutin-d₄ is deuterium labeled Arbutin. Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents[1]. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[2][3].

HY-W013636S

2-Ketoglutaric acid-13C5
2-Ketoglutaric acid- ¹³C₅ is the ¹³C labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

HY-W013636S1

2-Ketoglutaric acid-d4
2-Ketoglutaric acid-d₄ is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

HY-W013636S2

2-Ketoglutaric acid-d6
2-Ketoglutaric acid-d₆ is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

HY-N0136S1

(±)-Taxifolin-13C3

(±)-Taxifolin-13C3 ((±)-Dihydroquercetin-13C3) is a derivative of (±)-Taxifolin, labeled with 13C3. (±)-Taxifolin is the racemate of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .

HY-W013636S3

2-Ketoglutaric acid-13C

2-Ketoglutaric acid- ¹³C (Alpha-Ketoglutaric acid- ¹³C) is a ¹³C labeled 2-Ketoglutaric acid (HY-W013636) . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

Cat. No.	Product Name	Application	Reactivity

HY-P82777

Tyrosinase Antibody (YA2522)

ATN; CMM8; LB24 AB; SHEP3; SK29 AB; Tumor rejection antigen AB; TYR
WB, IHC-P, ICC/IF Human

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