β-glucuronidase

By Targets:	Bacterial (5) Biochemical Assay Reagents (2) Carbonic Anhydrase (3) Drug-Linker Conjugates for ADC (1) Endogenous Metabolite (1) Fluorescent Dye (4) Platelet-activating Factor Receptor (PAFR) (1)
By Research Areas:	Cancer (10) Infection (3) Inflammation/Immunology (4) Metabolic Disease (8) Neurological Disease (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103081

β-Glucuronidase-IN-1	Bacterial	Infection Cancer
β-Glucuronidase-IN-1 is a potent, selective, uncompetitive, and orally active E. coli bacterial β-glucuronidase inhibitor, exhibiting an IC₅₀ and a K_i of 283 nM and 164 nM, respectively .

HY-161341

β-Glucuronidase responsive conjugate 1	Others	Cancer
β-Glucuronidase responsive conjugate 1 (compound 3) is a well-balanced photosensitizer which has photodynamic activity. β-Glucuronidase responsive conjugate 1 inhibits T-24 cell viability and growth with an IC₅₀ of 0.2 μM. β-Glucuronidase responsive conjugate 1 can used to study bladder cancers .

HY-150977

β-Glucuronidase/hCAII-IN-2	Carbonic Anhydrase	Neurological Disease Metabolic Disease Cancer
β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a potent *β-glucuronidase* and hCA II inhibitor with an IC₅₀ of 670.7 μM and 21.77 μM, respectively .

HY-150976

β-Glucuronidase/hCAII-IN-1	Carbonic Anhydrase	Neurological Disease Metabolic Disease Cancer
β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a potent *β-glucuronidase* and hCA II inhibitor with an IC₅₀ of 440.1 μM and 4.91 μM, respectively .

HY-151166

β-Glucuronidase-IN-2	Bacterial	Cancer
β-Glucuronidase-IN-2 is a potent E. coli *β-glucuronidase* inhibitor with an IC₅₀ value of 0.24 μM, an K_i value of 1.09 μM. β-Glucuronidase-IN-2 shows antiproliferative activity. β-Glucuronidase-IN-2 has the potential for the research of anti-cancer and anti-inflammatory therapies .

HY-D1460

Fluorescein Di-β-D-Glucuronide	Bacterial	Infection
Fluorescein Di-β-D-Glucuronide, a fluorescent probe, can be utilized to non-invasively image the intestinal bacterial β-glucuronidase activity in nude mice. Fluorescein Di-β-D-Glucuronide-based imaging reveals the in vitro and in vivo activity of intestinal bacterial β-glucuronidase, which would facilitate pharmacodynamic studies of specific bacterial β-glucuronidase inhibitors in animal studies .

HY-D1578

C12FDGlcU	Fluorescent Dye	Others
C12FDGlcU is a lipophilic analog of fluorescein di-β-D-glucuronic acid. C12FDGlcU can be useful for the detection of *β-glucuronidase* (GUS) gene expression. C12FDGlcU can enter the cells and then be cleaved by β-glucuronidase, generating the yellow-colored, green-fluorescent fluorescein (Abs/Em of the reaction product: 495/518 nm) .

HY-N1322

Sanggenol A	Others	Others
Sanggenol A acts as a dual inhibitor of nitrofuranone reduction mediated by the intestinal microbial nitrification reductases EcNfsA and EcNfsB. In addition, Sanggenol A is also an effective inhibitor of intestinal bacterial β-glucuronidase .

HY-N3413

Kushenol X	Others	Metabolic Disease
Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent *β-glucuronidase* and human carboxylesterase 2 (hCE2) inhibitor with IC₅₀s of 2.07 μM and 3.05 μM, respectively .

HY-150973

hCAII-IN-4	Carbonic Anhydrase	Neurological Disease Metabolic Disease Cancer
hCAII-IN-4 (Compound 12j) is a potent hCA II inhibitor with an IC₅₀ of 7.78 μM. hCAII-IN-4 also inhibits *β-glucuronidase* with an IC₅₀ of 773.9 μM .

HY-137816

6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium	Others	Others
6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium salt is a chromogenic substrate for β-glucuronidase. 6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium salt produces a salmon colored precipitate upon cleavage .

HY-155313

β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE	Drug-Linker Conjugates for ADC	Cancer
β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE (compound 20) is auristatins-glucuronide conjugate. Antitumor agent-122 shows in vitro antiproliferative activities against β-glucuronidase pretreated and untreated cancer cells with an IC₅₀ value of 5.7 nM - 9.7 nM. Antitumor agent-122 shows potent antitumor efficacy in HCT-116 xenograft mouse model without inducing side effects .

HY-134453A

D-Saccharic acid 1,4-lactone hydrate	Others	Cancer
D-Saccharic acid 1,4-lactone hydrate is a potent *β-glucuronidase* inhibitor (IC₅₀=48.4 μM). D-Saccharic acid 1,4-lactone hydrate can be used as a standard agent compared with novel β-glucuronidase inhibitors. D-Saccharic acid 1,4-lactone hydrate possesses anticarcinogenic, detoxifying, and antioxidant properties .

HY-15935

*X-Gluc* Dicyclohexylamine**	Fluorescent Dye	Others
X-Gluc Dicyclohexylamine is a dye reagent for the detection of β-glucuronidase, an enzyme produced by Escherichia coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract. X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (GUS reporter system) .

HY-15935C

*X-Gluc* sodium**	Fluorescent Dye	Others
X-Gluc sodium is a dye reagent for the detection of *β-glucuronidase* (GUS), an enzyme produced by E. coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract (GUS as a specific detection indicator). X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (reacts with the GUS gene, appears blue) .

HY-148044

UNC10201652	Bacterial	Infection
UNC10201652 is a potent Loop 1 (L1)-specific gut bacterial β-glucuronidase (GUSs) inhibitor with an IC₅₀ value of 0.117 μM for E. coli GUS. UNC10201652 can block SN-38 glucuronide (HY-126373) processing only in individuals whose fecal gut microbiota is highly abundant in L1 GUS enzymes .

HY-N2998

Ganoderenic acid A	Others	Metabolic Disease
Ganoderenic acid A is a lanostane-type triterpene. Ganoderenic acid A is a potent inhibitor of *β-glucuronidase*. Ganoderenic acid A has a potent hepatoprotective effect against CCl4-induced liver injury .

HY-N7529

Siastatin B	Endogenous Metabolite	Others
Siastatin B is an effective broad-spectrum glycosidase inhibitor that can effectively inhibit the activities of sialidase, *β-D-glucuronidase, N-acetyl-glucosaminidase, β-glucuronidase, and human heparinase* .

HY-N2247A

(+)-Guaiacin	Platelet-activating Factor Receptor (PAFR)	Metabolic Disease
(+)-Guaiacin is a compound extracted of the bark of Machilus wangchiana Chun. (Lauraceae). (+)-Guaiacin shows potent in vitro activities against the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor (PAF) .

HY-W039892

4-Nitrophenyl β-D-glucuronide pNPG_1	Others	Others
4-Nitrophenyl β-D-glucuronide (pNPG_1) is aderivative of 4-nitrophenol 4-Nitrophenyl β-D-glucuronide is a chromogenic compound and is the chromogenic substrate for β-glucuronidase .

HY-N9975

4'',5''-Dehydroisopsoralidin	Others	Inflammation/Immunology Cancer
4'',5''-Dehydroisopsoralidin is a *β-glucuronidase* inhibitor (IC₅₀: 6.3 μM). 4'',5''-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4'',5''-Dehydroisopsoralidin can be used in the research of inflammation and cancners .

HY-N1733

2′-Hydroxydaidzein	Others	Inflammation/Immunology
2′-Hydroxydaidzein is a metabolite. 2′-Hydroxydaidzein inhibits the release of chemical mediator from inflammatory cells. 2′-Hydroxydaidzein significantly inhibits lysozyme and β-glucuronidase release from rat neutrophils, which is stimulated with fMLP/CB, respectively .

HY-D0935A

4-Methylumbelliferyl-β-D-glucuronide hydrate MUG	Fluorescent Dye	Others
4-Methylumbelliferyl-β-D-glucuronide hydrate is a fluorogenic substrat (λ_ex=362 nm, λ_em=445 nm). 4-Methylumbelliferyl-β-D-glucuronide hydrate has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli .

HY-D0935

4-Methylumbelliferyl-β-D-glucuronide
4-Methylumbelliferyl-β-D-glucuronide is a fluorogenic substrat (λ_ex=362 nm, λ_em=445 nm). 4-Methylumbelliferyl-β-D-glucuronide has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli .

HY-151168

3-Chlorogentisyl alcohol	Bacterial	Inflammation/Immunology Cancer
3-Chlorogentisyl alcohol is a potent E. coli *β-glucuronidase* inhibitor with an IC₅₀ value of 0.74 μM, an K_i value of 0.58 μM. 3-Chlorogentisyl alcohol shows antiproliferative activity. 3-Chlorogentisyl alcohol has the potential for the research of anti-cancer and anti-inflammatory therapies .

HY-N1735

2′-Hydroxygenistein
2′-Hydroxygenistein is a natural product that can be isolated from Crotalaria pallida and C. assamica. 2′-Hydroxygenistein shows anti-inflammatory activity. 2′-Hydroxygenistein shows significant concentration-dependent inhibitory effects on the release of *β-glucuronidase* and lysozyme from rat neutrophils, with IC₅₀ values of 5.9 ± 1.4 and 9.7 ± 3.5 μM, respectively .

HY-15935B

*X-Gluc* cyclohexanamine**
X-Gluc cyclohexanamine is a dye reagent for the detection of *β-glucuronidase* (GUS), an enzyme produced by E. coli. X-Gluc cyclohexanamine can be used to detect E. coli contamination in food, water and the urinary tract (GUS as a specific detection indicator). X-Gluc cyclohexanamine is also widely used in molecular biology experiments to label and detect the expression of target genes (reacts with the GUS gene, appears blue) .

HY-W154341

3-Indolyl-β-D-glucuronide cyclohexanamine	Biochemical Assay Reagents	Others
3-Indolyl-β-D-glucuronide cyclohexanamine is the glucose component of X-Gluc staining buffer. 3-Indolyl-β-D-glucuronide cyclohexanamine can be used to detect gene expression. The active ingredient of the stain, β-Glucuronidase (GUS), reacts with the enzyme, causing the target gene to appear blue-purple in tissues or cells, so that the expression level and tissue distribution of the gene can be visually observed .

HY-137426A

Phenolphthalein glucuronide sodium

Biochemical Assay Reagents Others

Phenolphthalein glucuronide sodium is a substrate to determine the β –glucuronidase .

Phenolphthalein glucuronide sodium	Biochemical Assay Reagents	Others
Phenolphthalein glucuronide sodium is a substrate to determine the β –glucuronidase .

HY-N6851

Glycyrrhetic acid 3-O-β-D-glucuronide Glycyrrhetic acid 3-O-mono-β-D-glucuronide; 3-monoglucuronyl-glycyrrhetinic acid	Others	Inflammation/Immunology
Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity . Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β-glucuronidases (β-GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG .Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener.

HY-N9248

6-Hydroxywogonin

Others Others

6-Hydroxywogonin (compound 26) is a flavonoid compound .

6-Hydroxywogonin	Others	Others
6-Hydroxywogonin (compound 26) is a flavonoid compound .

Cat. No.	Product Name	Type

HY-15935

*X-Gluc* Dicyclohexylamine**	Chromogenic Assays
X-Gluc Dicyclohexylamine is a dye reagent for the detection of β-glucuronidase, an enzyme produced by Escherichia coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract. X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (GUS reporter system) .

HY-15935C

*X-Gluc* sodium**	Fluorescent Dyes/Probes
X-Gluc sodium is a dye reagent for the detection of *β-glucuronidase* (GUS), an enzyme produced by E. coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract (GUS as a specific detection indicator). X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (reacts with the GUS gene, appears blue) .

X-Gluc sodium

Fluorescent Dyes/Probes

X-Gluc sodium is a dye reagent for the detection of β-glucuronidase (GUS), an enzyme produced by E. coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract (GUS as a specific detection indicator). X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (reacts with the GUS gene, appears blue) .

HY-D0935A

4-Methylumbelliferyl-β-D-glucuronide hydrate MUG	Chromogenic Substrates
4-Methylumbelliferyl-β-D-glucuronide hydrate is a fluorogenic substrat (λ_ex=362 nm, λ_em=445 nm). 4-Methylumbelliferyl-β-D-glucuronide hydrate has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli .

HY-D1460

Fluorescein Di-β-D-Glucuronide	Fluorescent Dyes/Probes
Fluorescein Di-β-D-Glucuronide, a fluorescent probe, can be utilized to non-invasively image the intestinal bacterial β-glucuronidase activity in nude mice. Fluorescein Di-β-D-Glucuronide-based imaging reveals the in vitro and in vivo activity of intestinal bacterial β-glucuronidase, which would facilitate pharmacodynamic studies of specific bacterial β-glucuronidase inhibitors in animal studies .

Fluorescein Di-β-D-Glucuronide

Fluorescent Dyes/Probes

Fluorescein Di-β-D-Glucuronide, a fluorescent probe, can be utilized to non-invasively image the intestinal bacterial β-glucuronidase activity in nude mice. Fluorescein Di-β-D-Glucuronide-based imaging reveals the in vitro and in vivo activity of intestinal bacterial β-glucuronidase, which would facilitate pharmacodynamic studies of specific bacterial β-glucuronidase inhibitors in animal studies .

HY-D1578

C12FDGlcU	Fluorescent Dyes/Probes
C12FDGlcU is a lipophilic analog of fluorescein di-β-D-glucuronic acid. C12FDGlcU can be useful for the detection of *β-glucuronidase* (GUS) gene expression. C12FDGlcU can enter the cells and then be cleaved by β-glucuronidase, generating the yellow-colored, green-fluorescent fluorescein (Abs/Em of the reaction product: 495/518 nm) .

Cat. No.	Product Name	Type

HY-P2803

Beta-glucuronidase (Escherichia coli)	Biochemical Assay Reagents
Beta-glucuronidase is an important lysosomal enzyme involved in the degradation of glucuronate-containing glycosaminoglycan .

HY-P2803A

Beta-glucuronidase (bovine liver)	Biochemical Assay Reagents
Beta-glucuronidase is an important lysosomal enzyme involved in the degradation of glucuronate-containing glycosaminoglycan .

Cat. No.	Product Name	Target	Research Area

HY-P2803A

Beta-glucuronidase (bovine liver)	Peptides	Metabolic Disease
Beta-glucuronidase is an important lysosomal enzyme involved in the degradation of glucuronate-containing glycosaminoglycan .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3413

Kushenol X	Flavanonols Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Metabolic Disease Plants Sophora flavescens Aiton Disease Research Fields	Others
Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent *β-glucuronidase* and human carboxylesterase 2 (hCE2) inhibitor with IC₅₀s of 2.07 μM and 3.05 μM, respectively .

HY-N2998

Ganoderenic acid A	Triterpenes Human Gut Microbiota Metabolites other families Microorganisms Classification of Application Fields Terpenoids Source classification Metabolic Disease Plants Endogenous metabolite Disease Research Fields	Others
Ganoderenic acid A is a lanostane-type triterpene. Ganoderenic acid A is a potent inhibitor of *β-glucuronidase*. Ganoderenic acid A has a potent hepatoprotective effect against CCl4-induced liver injury .

HY-N1322

Sanggenol A	Structural Classification Flavonoids Flavones Source classification Plants Moraceae Morus alba Linn.	Others
Sanggenol A acts as a dual inhibitor of nitrofuranone reduction mediated by the intestinal microbial nitrification reductases EcNfsA and EcNfsB. In addition, Sanggenol A is also an effective inhibitor of intestinal bacterial β-glucuronidase .

HY-N2247A

(+)-Guaiacin	Structural Classification Classification of Application Fields Source classification Lignans Phenols Polyphenols Metabolic Disease Phenylpropanoids Plants Lauraceae Machilus wangchiana Chun Disease Research Fields	Platelet-activating Factor Receptor (PAFR)
(+)-Guaiacin is a compound extracted of the bark of Machilus wangchiana Chun. (Lauraceae). (+)-Guaiacin shows potent in vitro activities against the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor (PAF) .

HY-N9975

4'',5''-Dehydroisopsoralidin	Structural Classification Classification of Application Fields Solanum lyratum Thunberg Coumarins Phenylpropanoids Plants Solanaceae Inflammation/Immunology Disease Research Fields Cancer	Others
4'',5''-Dehydroisopsoralidin is a *β-glucuronidase* inhibitor (IC₅₀: 6.3 μM). 4'',5''-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4'',5''-Dehydroisopsoralidin can be used in the research of inflammation and cancners .

HY-N1733

2′-Hydroxydaidzein	Structural Classification Flavonoids Leguminosae Source classification Plants Crotalaria pallida Ait. Isoflavones	Others
2′-Hydroxydaidzein is a metabolite. 2′-Hydroxydaidzein inhibits the release of chemical mediator from inflammatory cells. 2′-Hydroxydaidzein significantly inhibits lysozyme and β-glucuronidase release from rat neutrophils, which is stimulated with fMLP/CB, respectively .

HY-N6851

Glycyrrhetic acid 3-O-β-D-glucuronide Glycyrrhetic acid 3-O-mono-β-D-glucuronide; 3-monoglucuronyl-glycyrrhetinic acid	Triterpenes Structural Classification Classification of Application Fields Leguminosae Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Sweeteners Glycyrrhiza uralensis Fisch. Food Research	Others
Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity . Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β-glucuronidases (β-GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG .Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener.

HY-N9248

6-Hydroxywogonin

Structural Classification Flavonoids Microorganisms Flavones Source classification

Others

6-Hydroxywogonin (compound 26) is a flavonoid compound .

Cat. No.	Compare	Product Name	Species	Source

HY-P70258

	Beta-glucuronidase/GUSB Protein, E.coli (N-His,Solution) rE.coBeta-glucuronidase/GUSB, His; Beta-glucuronidase; uidA; GUS	E.coli	E. coli
	The beta-glucuronidase/GUSB protein displays activity with PNPG and 4-methylumbelliferyl-glucuronide. It scavenges glucuronate from various xenobiotic and endobiotic glucuronides in the GI tract, utilizing diverse carbon sources. As part of the GI microbiome, it can reactivate glucuronide drug conjugates, potentially harming the GI tract. Beta-glucuronidase/GUSB Protein, E.coli (N-His,Solution) is the recombinant E. coli-derived Beta-glucuronidase/GUSB protein, expressed by E. coli , with N-6*His labeled tag. The total length of Beta-glucuronidase/GUSB Protein, E.coli (N-His,Solution) is 603 a.a., with molecular weight of 69-78 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P83108

beta Glucuronidase Antibody (YA2853)

GUSB; Beta-glucuronidase; Beta-G1
WB, IHC-P, ICC/IF, FC Human


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Antibodies