β-hexosaminidase

By Targets:	Calcium Channel (1) Fluorescent Dye (1) Histamine Receptor (1) Influenza Virus (1) Interleukin Related (1) Monoamine Oxidase (1) TNF Receptor (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-104050

M-31850	Others	Metabolic Disease
M-31850 is a potent, selective and competitive β-hexosaminidase (Hex) inhibitor with IC₅₀s of 6.0 µM and 3.1 µM for human HexA and human HexB, respectively. M-31850 also competitively inhibits β-N-acetyl-D-hexosaminidase OfHex2 with a K_i of 2.5 μM .

HY-113242

5-Nonadecylresorcinol

Others Others

5-Nonadecylresorcinol is an alkylresorcinol and has inhibitory effects on the release of β-hexosaminidase in vitro .

5-Nonadecylresorcinol	Others	Others
5-Nonadecylresorcinol is an alkylresorcinol and has inhibitory effects on the release of *β-hexosaminidase* in vitro .

HY-N12116

Maceneolignan A	TNF Receptor	Cancer
Maceneolignan A is a natural product that can be isolated from mace, the aril of Myristica fragrans (Myristicaceae). Maceneolignan A inhibits the release of *β-hexosaminidase* in RBL-2H3 cells, with an IC₅₀ of 48.4 μM. Maceneolignan A inhibits the release of TNF-α in antigen stimulated RBL-2H3 cells, with an IC₅₀ of 63.7 μM .

HY-N8426

4'-O-Methylnyasol Ellisinin A	Histamine Receptor	Cancer
4'-O-Methylnyasol is an inhibitor of *β-hexosaminidase. 4'-O-Methylnyasol inhibits β-hexosaminidase* release from rat basophilic leukemia-2H3 cells with an IC₅₀ of 52.67 μM .

HY-N3815

ent-16-Kaurene-3b,15b,18-triol	Others	Inflammation/Immunology
ent-16-Kaurene-3b,15b,18-triol is a ent-kaurene diterpene. ent-16-Kaurene-3b,15b,18-triol has significant antiallergic activity on β-hexosaminidase release induced by Polyginseng antigen .

HY-143285

AMC-GlcNAc	Fluorescent Dye
AMC-GlcNAc (compound 1) is a potent fluorogenic probe for detection and characterization of β-hexosaminidase enzyme activity. AMC-GlcNAc enables continuous monitoring by turn-on fluorescence and fluorescence signal is constant over a wide pH range (Ex=325 nm, Em=390 nm). AMC-GlcNAc enables ratiometric fluorescence detection with high sensitivity and low background, which can be used to screen for recombinant dispersin B activity in E. coli cell lysate .

HY-N2426

Clerodendrin	Interleukin Related	Inflammation/Immunology
Clerodendrin is a nature product could be isolated from Lobelia chinensis. Clerodendrin is a potent dual Interleukin-4 (IL-4) inhibitor and β-hexosaminidase (Hex) inhibitor .

HY-N4267

Yangambin	Calcium Channel	Infection Cardiovascular Disease
Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca ²⁺ influx through voltage-gated Ca ²⁺ channels, leading to the reduction in [Ca ²⁺]i in vascular smooth muscle cells and consequent peripheral vasodilation . Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC₅₀ of 33.8 μM and for anti-inflammatory activity with an IC₅₀ of 37.4 μM .

HY-114203

Eckol	Monoamine Oxidase Influenza Virus	Infection Neurological Disease Inflammation/Immunology
Eckol is a potent hMAO-A (Mixed) and hMAO-B (non-competitive) inhibitor with IC₅₀s of 7.20 and 83.44 μM, respectively. Eckol shows stimulatory effects in maize and can be used as a plant biostimulant. Eckol also shows antiallergic and antiviral effects .

Cat. No.	Product Name	Type

HY-143285

AMC-GlcNAc	Fluorescent Dyes/Probes
AMC-GlcNAc (compound 1) is a potent fluorogenic probe for detection and characterization of β-hexosaminidase enzyme activity. AMC-GlcNAc enables continuous monitoring by turn-on fluorescence and fluorescence signal is constant over a wide pH range (Ex=325 nm, Em=390 nm). AMC-GlcNAc enables ratiometric fluorescence detection with high sensitivity and low background, which can be used to screen for recombinant dispersin B activity in E. coli cell lysate .

AMC-GlcNAc

Fluorescent Dyes/Probes

AMC-GlcNAc (compound 1) is a potent fluorogenic probe for detection and characterization of β-hexosaminidase enzyme activity. AMC-GlcNAc enables continuous monitoring by turn-on fluorescence and fluorescence signal is constant over a wide pH range (Ex=325 nm, Em=390 nm). AMC-GlcNAc enables ratiometric fluorescence detection with high sensitivity and low background, which can be used to screen for recombinant dispersin B activity in E. coli cell lysate .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2426

Clerodendrin	Clerodendrum trichotomum Thunb. Flavonoids Verbenaceae Plants Isoflavones	Interleukin Related
Clerodendrin is a nature product could be isolated from Lobelia chinensis. Clerodendrin is a potent dual Interleukin-4 (IL-4) inhibitor and β-hexosaminidase (Hex) inhibitor .

HY-113242

5-Nonadecylresorcinol	Structural Classification Source classification Agrostidoideae Phenols Polyphenols Plants Triticum aestivum L.	Others
5-Nonadecylresorcinol is an alkylresorcinol and has inhibitory effects on the release of *β-hexosaminidase* in vitro .

HY-N12116

Maceneolignan A	Structural Classification Monophenols Source classification Phenols Myristicaceae Plants Myristica fragrans Houtt.	TNF Receptor
Maceneolignan A is a natural product that can be isolated from mace, the aril of Myristica fragrans (Myristicaceae). Maceneolignan A inhibits the release of *β-hexosaminidase* in RBL-2H3 cells, with an IC₅₀ of 48.4 μM. Maceneolignan A inhibits the release of TNF-α in antigen stimulated RBL-2H3 cells, with an IC₅₀ of 63.7 μM .

HY-N8426

4'-O-Methylnyasol Ellisinin A	Structural Classification Natural Products Liliaceae Source classification Anemarrhena asphodeloides Bunge Plants	Histamine Receptor
4'-O-Methylnyasol is an inhibitor of *β-hexosaminidase. 4'-O-Methylnyasol inhibits β-hexosaminidase* release from rat basophilic leukemia-2H3 cells with an IC₅₀ of 52.67 μM .

HY-N3815

ent-16-Kaurene-3b,15b,18-triol	Structural Classification Suregada multiflora (Jussieu) Baillon Terpenoids Source classification Diterpenoids Euphorbiaceae Plants	Others
ent-16-Kaurene-3b,15b,18-triol is a ent-kaurene diterpene. ent-16-Kaurene-3b,15b,18-triol has significant antiallergic activity on β-hexosaminidase release induced by Polyginseng antigen .

HY-N4267

Yangambin	Cardiovascular Disease other families Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Disease Research Fields	Calcium Channel
Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca ²⁺ influx through voltage-gated Ca ²⁺ channels, leading to the reduction in [Ca ²⁺]i in vascular smooth muscle cells and consequent peripheral vasodilation . Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC₅₀ of 33.8 μM and for anti-inflammatory activity with an IC₅₀ of 37.4 μM .

HY-114203

Eckol	Eisenia bicyclis Structural Classification other families Source classification Phenols Polyphenols Plants	Monoamine Oxidase Influenza Virus
Eckol is a potent hMAO-A (Mixed) and hMAO-B (non-competitive) inhibitor with IC₅₀s of 7.20 and 83.44 μM, respectively. Eckol shows stimulatory effects in maize and can be used as a plant biostimulant. Eckol also shows antiallergic and antiviral effects .

Species:	Human (2) Mouse (1)
Tag:	His (4)
Source:	HEK293 (2) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P74890

	*HEXB/Hexosaminidase* B Protein, Human (HEK293, His)** Beta-hexosaminidase subunit beta; HCC-7; HEXB	Human	HEK293
	HEXB (hexosaminidase B) proteolytically hydrolyzes N-acetyl-D-hexosamine and/or sulfated residues in glycoconjugates, including oligosaccharides, glycolipids, and mucopolysaccharides. B isoenzymes efficiently hydrolyze neutral oligosaccharides, making them unique. HEXB/Hexosaminidase B Protein, Human (HEK293, His) is the recombinant human-derived HEXB/Hexosaminidase B protein, expressed by HEK293 , with C-His labeled tag. The total length of HEXB/Hexosaminidase B Protein, Human (HEK293, His) is 514 a.a., with molecular weight of 60-66 kDa.

HY-P75808

	*HEXB/Hexosaminidase* B Protein, Mouse (HEK293, His)** Beta-hexosaminidase subunit beta; HCC-7; HEXB	Mouse	HEK293
	HEXB, or Hexosaminidase B protein, hydrolyzes N-acetyl-D-hexosamine in glycoconjugates. It selectively acts on neutral oligosaccharides, not degrading other substrates. HEXB does not degrade GM2 gangliosides; only isozyme A does. During fertilization, HEXB contributes to the zona block to polyspermy by inactivating the sperm galactosyltransferase-binding site. This mechanism prevents sperm binding to the zona pellucida. HEXB/Hexosaminidase B Protein, Mouse (HEK293, His) is the recombinant mouse-derived HEXB/Hexosaminidase B protein, expressed by HEK293 , with C-His labeled tag. The total length of HEXB/Hexosaminidase B Protein, Mouse (HEK293, His) is 505 a.a., with molecular weight of ~59.4 kDa.

HY-P79242

	O-GlcNAcase/OGA Protein, B. thetaiotaomicron (His) O-GlcNAcase BT_4395; Beta-N-acetylglucosaminidase; Beta-N-acetylhexosaminidase; Beta-hexosaminidase; hexosaminidase B; N-acetyl-beta-glucosaminidase	Others	E. coli
	O-GlcNAcase (OGA) is an enzyme with the capability to hydrolyze the glycosidic link in O-GlcNAcylated proteins. In vitro, it demonstrates the ability to utilize substrates such as p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc. O-GlcNAcase/OGA Protein, B. thetaiotaomicron (His) is the recombinant O-GlcNAcase/OGA protein, expressed by E. coli , with N-6*His labeled tag. The total length of O-GlcNAcase/OGA Protein, B. thetaiotaomicron (His) is 716 a.a., with molecular weight of 80-95 kDa.

HY-P73099

	*HEXA/Hexosaminidase* A Protein, Human (sf9, His)** Beta-hexosaminidase subunit alpha; HEXA; hexosaminidase A; TSD	Human	Sf9 insect cells
	HEXA (hexosaminidase A) proteolytically hydrolyzes N-acetyl-D-hexosamine and/or sulfated residues in glycocomplexes, including oligosaccharides, glycolipids, and mucopolysaccharides. The activity of isoenzyme S towards anionic disulfated glycans is comparable to that of isoenzyme A, while isoenzyme B can effectively hydrolyze neutral oligosaccharides but cannot hydrolyze anionic disulfated substrates. HEXA/Hexosaminidase A Protein, Human (sf9, His) is the recombinant human-derived HEXA/Hexosaminidase A protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of HEXA/Hexosaminidase A Protein, Human (sf9, His) is 529 a.a., with molecular weight of ~64 kDa.


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Fluorescent Dye

Natural
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Recombinant Proteins