β-tubulin

By Targets:	Microtubule/Tubulin (17) Apoptosis (6) Autophagy (2) Bcr-Abl (1) CRISPR/Cas9 (1) Fluorescent Dye (1) HPV (1) VEGFR (1)
By Research Areas:	Cancer (16)

Targets Recommended: Microtubule/Tubulin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13598

Valecobulin CKD-516	Microtubule/Tubulin	Cancer
Valecobulin (CKD516) is a valine proagent of (S516) and a vascular disrupting agent (VDA). Valecobulin is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors .

HY-13598A

Valecobulin hydrochloride CKD-516 hydrochloride	Microtubule/Tubulin	Cancer
Valecobulin hydrochloride (CKD-516 hydrochloride) is a valine proagent of S516 (HY-130233) and a vascular disrupting agent (VDA). Valecobulin hydrochloride is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors .

HY-13563

Batabulin T138067	Microtubule/Tubulin Apoptosis	Cancer
Batabulin (T138067) is an antitumor agent, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to cell-cycle arrest ultimately induces apoptotic cell death .

HY-13563A

Batabulin sodium T138067 sodium	Microtubule/Tubulin Apoptosis	Cancer
Batabulin sodium (T138067 sodium) is an antitumor agent, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin sodium affects cell morphology and leads to cell-cycle arrest ultimately induces apoptotic cell death .

HY-155350

Tubulin polymerization-IN-53	Microtubule/Tubulin	Others
Tubulin polymerization-IN-53 (compound 4b) is an inhibitor of β-tubulin polymerization. Tubulin polymerization-IN-53 can arrest the cell cycle at the G2/M stage. Tubulin polymerization-IN-53 has antiproliferative efficacy against the MDA-MB-231 cell line with an IC₅₀ value of 3.24 μM .

HY-16777

Entasobulin

2 Publications Verification

Microtubule/Tubulin Cancer

Entasobulin is a β-tubulin polymerization inhibitor with potential anticancer activity.
HY-N2146

Combretastatin A4

2 Publications Verification

CRC 87-09
Microtubule/Tubulin Cancer

Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with K_d of 0.4 μM.

Entasobulin 2 Publications Verification	Microtubule/Tubulin	Cancer
Entasobulin is a *β-tubulin* polymerization inhibitor with potential anticancer activity.

Combretastatin A4 2 Publications Verification CRC 87-09	Microtubule/Tubulin	Cancer
Combretastatin A4 is a microtubule-targeting agent that binds *β-tubulin* with K_d of 0.4 μM.

HY-116915

Synstab A	Microtubule/Tubulin	Cancer
Synstab A is a mitosis modulator to promote interactions between α- and β-tubulin. Synstab A can polymerizes microtubules from purified tubulin, and produces microtubule bundles in interphase cells .

HY-106825

Clanfenur	Microtubule/Tubulin	Cancer
Clanfenur is a substituted benzoylphenylurea, an analogue of the pesticide fenfluramide, with potential antineoplastic activity. Clanfenur can bind to the colchicine-binding site on β-tubulin, inhibit microtubule polymerization, and thus prevent tumor cell replication .

HY-147872

VEGFR-2-IN-22	VEGFR Microtubule/Tubulin Apoptosis	Cancer
VEGFR-2-IN-22 (Compound 25) is a dual VEGFR-2 and *β-tubulin* polymerization inhibitor with an IC₅₀ of 19.82 nM against VEGFR-2. VEGFR-2-IN-22 induces apoptosis .

HY-13520

Nocodazole Maximum Cited Publications 53 Publications Verification Oncodazole; R17934	Microtubule/Tubulin Bcr-Abl CRISPR/Cas9 Autophagy Apoptosis	Cancer
Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl, and activates CRISPR/Cas9.

HY-14444

Plinabulin NPI-2358	Microtubule/Tubulin	Cancer
Plinabulin (NPI-2358) is a vascular disrupting agen (VDA) against *tubulin-depolymerizing* with an IC₅₀ of 9.8 nM against HT-29 cells . Plinabulin binds the colchicine binding site of *β-tubulin* preventing polymerization and has potent inhibitory to tumor cells .

HY-143247

Tubulin polymerization-IN-2	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-2 is a potent anticancer agent targeting to *β-tubulin* with an IC₅₀ value of 0.92 μM. Tubulin polymerization-IN-2 shows promising activity against various leukemia, non-small lung, renal, prostate, and breast cancer cell lines .

HY-114302

CCB02	Microtubule/Tubulin	Cancer
CCB02 is a selective *CPAP-tubulin* interaction** inhibitor, binding to tubulin and competing for the CPAP binding site of β-tubulin, with an IC₅₀ of 689 nM, and shows potent anti-tumor activity. CCB02 shows no inhibition on the cell cycle- and centrosome-related kinases, or the phosphorylation status of Aurora A, Plk1, Plk2, CDK2, and CHK1 .

HY-13270

ABT-751 E7010	Microtubule/Tubulin Autophagy Apoptosis	Cancer
ABT-751 (E7010) is a novel, highly orally bioavailable sulfonamides antimitotic compound and tubulin binder. It prevents tubulin aggregation by binding to the colchicine site on β-tubulin, leading to cell cycle arrest in G2/M phase and inducing apoptosis, thus effectively preventing cell division. ABT-751 induces autophagy by inhibiting the AKT/MTOR signaling pathway. ABT-751 showed significant inhibition against various types of cancer cells, including lung, gastric, colon, and breast cancer .

HY-131010

Flutax-2 (5/6-mixture)	Fluorescent Dye Microtubule/Tubulin	Cancer
Flutax-2 (5/6-mixture) is an active fluorescent derivative of paclitaxel. Flutax-2 (5/6-mixture) binds to a polymerized α,β tubulin dimer. Excitation/emission wavelength: 496/524 nm. Paclitaxel, a diterpenoid secondary metabolite produced by Taxus species, can be used for the research of a variety of cancers .

HY-120599

Sabizabulin 2 Publications Verification VERU-111; ABI-231	Microtubule/Tubulin Apoptosis HPV	Cancer
VERU-111 (ABI-231) is a potent and orally active α and β tubulin inhibitor, which displays strong antiproliferative activity, with an average IC₅₀ of 5.2 nM against panels of melanoma and prostate cancer cell lines. VERU-111 (ABI-231) suppresses tumor growth and metastatic phenotypes of cervical cancer cells via targeting HPV E6 and E7, and has potential for the treatment of prostate cancer .

Cat. No.	Product Name	Type

HY-131010

Flutax-2 (5/6-mixture)	Dyes
Flutax-2 (5/6-mixture) is an active fluorescent derivative of paclitaxel. Flutax-2 (5/6-mixture) binds to a polymerized α,β tubulin dimer. Excitation/emission wavelength: 496/524 nm. Paclitaxel, a diterpenoid secondary metabolite produced by Taxus species, can be used for the research of a variety of cancers .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2146

Combretastatin A4 2 Publications Verification CRC 87-09	Structural Classification Monophenols other families Stilbenes Classification of Application Fields Source classification Phenols Plants Disease Research Fields Cancer	Microtubule/Tubulin
Combretastatin A4 is a microtubule-targeting agent that binds *β-tubulin* with K_d of 0.4 μM.

Cat. No.	Compare	Product Name	Species	Source

HY-P71075

	TUBB4A Protein, Human (His) tubulin Beta-4A Chain; tubulin 5 Beta; tubulin Beta-4 Chain; TUBB4A; TUBB4; TUBB5	Human	E. coli
	TUBB4A protein, the main constituent of microtubules, forms cylindrical structures via lateral association of alpha- and beta-tubulin protofilaments. Microtubule growth, facilitated by GTP-tubulin dimers, leads to a stabilizing cap. Below this, TUBB4A dimers transition to a GDP-bound state, regulated by alpha-tubulin's GTPase activity. This intricate mechanism highlights TUBB4A's crucial role in governing microtubule assembly and stability. TUBB4A Protein, Human (His) is the recombinant human-derived TUBB4A protein, expressed by E. coli , with N-6*His labeled tag. The total length of TUBB4A Protein, Human (His) is 444 a.a., with molecular weight of ~58.0 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P80487

beta Tubulin Antibody	WB, ICC, IHC-P, FC	Human, Mouse, Rat
beta Tubulin Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 50 kDa, targeting to beta Tubulin. It can be used for WB,ICC,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80955

beta Tubulin Antibody (YA839) Human,Mouse,Monkey,Goat,Hamster,Rat,ChlamydomonasReinhardtii	WB, ICC/IF	Human, Mouse, Monkey, Goat, Hamster, Rat, Chlamydomonas Reinhardtii
beta Tubulin Antibody (YA839) is a non-conjugated and Mouse origined monoclonal antibody about 50-55 kDa, targeting to Tubulin beta chain (TUBB). It can be used for WB,ICC/IF assays in the background of Human, Mouse, Monkey, Goat, Hamster, Rat, Chlamydomonas Reinhardtii.

HY-P80955A

beta Tubulin Antibody (HRP) (YA865)	WB	Human, Mouse, Monkey, Hamster, Rat
beta Tubulin Antibody (HRP) (YA865) is an approximately 50-55 kDa, mouse-derived, anti-beta Tubulin (HRP) (YA865) monoclonal antibody. beta Tubulin Antibody (HRP) (YA865) can be used for: WB expriments in human, mouse, monkey, hamster, rat background with HRP labeling.

HY-P83265

beta II Tubulin Antibody (YA3010)

class II beta tubulin isotype; Beta2; tubulin beta 2 chain; TUBB; TUBB2
WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

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β-tubulin

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