1. Immunology/Inflammation
    NF-κB
  2. NOD-like Receptor (NLR)
    NF-κB
    Keap1-Nrf2

seco-Isolariciresinol Diglucoside (Synonyms: LGM2605)

Cat. No.: HY-N0727 Purity: 99.74%
Handling Instructions

seco-Isolariciresinol Diglucoside, a synthetic lignin, which is derived from the natural plant flaxseed. seco-Isolariciresinol Diglucoside reduces asbestos-induced NLRP3 expression, and NF-κB activation in macrophages (MF). seco-Isolariciresinol Diglucoside also activates Nrf2.

For research use only. We do not sell to patients.

seco-Isolariciresinol Diglucoside Chemical Structure

seco-Isolariciresinol Diglucoside Chemical Structure

CAS No. : 148244-82-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 143 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg USD 440 In-stock
Estimated Time of Arrival: December 31
100 mg USD 750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of seco-Isolariciresinol Diglucoside:

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  • Biological Activity

  • Technical Information

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  • References

Description

seco-Isolariciresinol Diglucoside, a synthetic lignin, which is derived from the natural plant flaxseed. seco-Isolariciresinol Diglucoside reduces asbestos-induced NLRP3 expression, and NF-κB activation in macrophages (MF). seco-Isolariciresinol Diglucoside also activates Nrf2.

IC50 & Target

NLRP3, NF-κB, Nrf2[1]

In Vitro

seco-Isolariciresinol Diglucoside (LGM2605) is a nontoxic lignan with anti-inflammatory and antioxidant properties and is evaluated for protection from asbestos in murine peritoneal macrophages (MF). seco-Isolariciresinol Diglucoside significantly reduces NLRP3 ranging from 40 to 81%, IL-1β by 89-96%, and TNFα by 67-78%, as well as activated NF-κB by 48-49% while decreasing levels of nitrates/nitrites by 85-93%. seco-Isolariciresinol Diglucoside reduces asbestos-induced NLRP3 expression, proinflammatory cytokine release, NF-κB activation, and nitrosative stress in macrophages (MF) supporting its possible use in preventing the asbestos-induced inflammatory cascade leading to malignancy. seco-Isolariciresinol Diglucoside inhibits NF-κB expression and prevents asbestos-induced iNOS expression and nitric oxide production by murine peritoneal macrophages. seco-Isolariciresinol Diglucoside activates Nrf2 and induces the expression of cellular antioxidant and detoxification enzymes[1].

Solvent & Solubility
In Vitro: 

DMSO : ≥ 83.33 mg/mL (115.30 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3836 mL 6.9182 mL 13.8364 mL
5 mM 0.2767 mL 1.3836 mL 2.7673 mL
10 mM 0.1384 mL 0.6918 mL 1.3836 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

722.73

Formula

C₃₂H₅₀O₁₈

CAS No.

148244-82-0

SMILES

OC[[email protected]@H](O[[email protected]@H](O)[[email protected]](O)[[email protected]]1O)[[email protected]]1O.OC[[email protected]@H]([[email protected]](CO)CC2=CC(OC)=C(O)C=C2)CC3=CC(OC)=C(O)C=C3.OC[[email protected]@H](O[[email protected]@H](O)[[email protected]](O)[[email protected]]4O)[[email protected]]4O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
seco-Isolariciresinol Diglucoside
Cat. No.:
HY-N0727
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seco-Isolariciresinol Diglucoside

Cat. No.: HY-N0727