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Serelaxin (Synonyms: RLX-030)

Cat. No.: HY-112999
Handling Instructions

Serelaxin (RLX-030), a recombinant form of human gene-2 relaxin targeting the RLN receptor, is a vasoactive peptide hormone with an antifibrotic activity.

For research use only. We do not sell to patients.

Serelaxin Chemical Structure

Serelaxin Chemical Structure

CAS No. : 99489-94-8

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Serelaxin (RLX-030), a recombinant form of human gene-2 relaxin targeting the RLN receptor, is a vasoactive peptide hormone with an antifibrotic activity[1][2][3].

In Vivo

Serelaxin (0.5 mg/kg per day, subcutaneous administration) produces 20 to 40 ng/mL of circulating hormone, which successfully prevents and reduces fibrosis progression in various experimental models of injury. The doses do not exhibit significant toxicity[1].
Serelaxin restores endothelial function by increasing nitric oxide (NO)-mediated relaxation but not endothelium-derived hyperpolarisation (EDH)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six- to 8-week-old male mice (on a 129sv or 129sv×C57B6J background, which were equally sensitive to tissue injury and fibrosis)[1].
Dosage: 0.5 mg/kg.
Administration: Subcutaneous administration per day for 7 days.
Result: Produced 20 to 40 ng/mL of circulating hormone.
Clinical Trial



Chain 1:{Asp}{Ser}{Trp}{Met}{Glu}{Glu}{Val}{Ile}{Lys}{Leu}{Cys}{Gly}{Arg}{Glu}{Leu}{Val}{Arg}{Ala}{Gln}{Ile}{Ala}{Ile}{Cys}{Gly}{Met}{Ser}{Thr}{Trp}{Ser} Chain 2:{Glp}{Leu}{Tyr}{Ser}{Ala}{Leu}{Ala}{Asn}{Lys}{Cys}{Cys}{His}{Val}{Gly}{Cys}{Thr}{Lys}{Arg}{Ser}{Leu}{Ala}{Arg}{Phe}{Cys} (Disulfide bridge:Cys11-Cys11';Cys23-Cys-24';Cys10'-Cys15')

Sequence Shortening

Chain 1:DSWMEEVIKLCGRELVRAQIAICGMSTWS Chain 2:{Glp}LYSALANKCCHVGCTKRSLARFC (Disulfide bridge:Cys11-Cys11';Cys23-Cys-24';Cys10'-Cys15')




Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

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