1. Others
  2. Others
  3. Serelaxin

Serelaxin (Synonyms: RLX-030)

Cat. No.: HY-112999
Handling Instructions

Serelaxin (RLX-030), a recombinant form of human gene-2 relaxin targeting the RLN receptor, is a vasoactive peptide hormone with an antifibrotic activity.

For research use only. We do not sell to patients.

Serelaxin Chemical Structure

Serelaxin Chemical Structure

CAS No. : 99489-94-8

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Serelaxin (RLX-030), a recombinant form of human gene-2 relaxin targeting the RLN receptor, is a vasoactive peptide hormone with an antifibrotic activity[1][2][3].

In Vivo

Serelaxin (0.5 mg/kg per day, subcutaneous administration) produces 20 to 40 ng/mL of circulating hormone, which successfully prevents and reduces fibrosis progression in various experimental models of injury. The doses do not exhibit significant toxicity[1].
Serelaxin restores endothelial function by increasing nitric oxide (NO)-mediated relaxation but not endothelium-derived hyperpolarisation (EDH)[2].

Animal Model: Six- to 8-week-old male mice (on a 129sv or 129sv×C57B6J background, which were equally sensitive to tissue injury and fibrosis)[1].
Dosage: 0.5 mg/kg.
Administration: Subcutaneous administration per day for 7 days.
Result: Produced 20 to 40 ng/mL of circulating hormone.
CAS No.

99489-94-8

Sequence

Chain 1:{Asp}{Ser}{Trp}{Met}{Glu}{Glu}{Val}{Ile}{Lys}{Leu}{Cys}{Gly}{Arg}{Glu}{Leu}{Val}{Arg}{Ala}{Gln}{Ile}{Ala}{Ile}{Cys}{Gly}{Met}{Ser}{Thr}{Trp}{Ser} Chain 2:{Glp}{Leu}{Tyr}{Ser}{Ala}{Leu}{Ala}{Asn}{Lys}{Cys}{Cys}{His}{Val}{Gly}{Cys}{Thr}{Lys}{Arg}{Ser}{Leu}{Ala}{Arg}{Phe}{Cys} (Disulfide bridge:Cys11-Cys11';Cys23-Cys-24';Cys10'-Cys15')

Sequence Shortening

Chain 1:DSWMEEVIKLCGRELVRAQIAICGMSTWS Chain 2:{Glp}LYSALANKCCHVGCTKRSLARFC (Disulfide bridge:Cys11-Cys11';Cys23-Cys-24';Cys10'-Cys15')

SMILES

[Serelaxin]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SerelaxinRLX-030RLX030RLX 030OthersSTZNOfibrosishormoneacuteheartfailureInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Serelaxin
Cat. No.:
HY-112999
Quantity:
MCE Japan Authorized Agent: