Shishijimicin B 

Shishijimicin B is an active compound of the enediyne class. Shishijimicin B shows extremely potent cytotoxicity with IC₅₀ values of 2.0-3.3 nM. Shishijimicin B has antitumor activity and can be used for the research of cancer^[1]. Shishijimicin B is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50: 3.1 nM (3Y1 cells); 3.3 nM (Hela cells); 2.0 nM (P388 cells)^[1]

Shishijimicin B (compound 2) has high cytotoxicity for 3Y1, Hela and P388 cells with IC₅₀ values of 3.1 nM, 3.3 nM and 2.0 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

935.09

C₄₅H₅₀N₄O₁₂S₃

503860-51-3

CSSSC/C=C([C@]1(C2)O)\C([C@H](C#C/C=C\C#C1)O[C@H](O[C@@H]3C)[C@@H]([C@H]([C@@H]3C(C4=C(NC5=CC=C6O)C(C5=C6)=CC=N4)=O)O)O[C@H](OC[C@@H]7NC(C)C)C[C@@H]7OC)=C(C2=O)NC(OC)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Naoya Oku, et al. Shishijimicins A-C, novel enediyne antitumor antibiotics from the ascidian Didemnum proliferum(1). J Am Chem Soc. 2003 Feb 26;125(8):2044-5.  [Content Brief]