1. Cell Cycle/DNA Damage Epigenetics
  2. Sirtuin
  3. SIRT1/2/3-IN-1

SIRT1/2/3-IN-1 (compound 10) is a highly potent, selective and cell permeable inhibitor of SIRT1, SIRT2 and SIRT3 with IC50s of 0.54, 0.253, and 0.72 μM, respectively. SIRT1/2/3-IN-1 (compound 10) can be used for research of cancer.

For research use only. We do not sell to patients.

SIRT1/2/3-IN-1 Chemical Structure

SIRT1/2/3-IN-1 Chemical Structure

CAS No. : 2413212-06-1

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Description

SIRT1/2/3-IN-1 (compound 10) is a highly potent, selective and cell permeable inhibitor of SIRT1, SIRT2 and SIRT3 with IC50s of 0.54, 0.253, and 0.72 μM, respectively. SIRT1/2/3-IN-1 (compound 10) can be used for research of cancer[1].

IC50 & Target

IC50: 0.54 μM (SIRT1), 0.253 μM (SIRT2), and 0.72 μM (SIRT3)[1]

In Vitro

SIRT1/2/3-IN-1 (compound 10) possesses cell growth inhibition to cancer cells with time- and concentration-dependently[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HCT116 human colon cancer cells
Concentration: 0, 0.5, 2, 10, 50, and 100 µM
Incubation Time: 8 h
Result: Inhibited deacetylation of the K382-acetylated tumor suppresser protein p53.

Cell Proliferation Assay[1]

Cell Line: Human MCF-7 breast cancer cells and human SK-MEL-2 melanoma cells
Concentration: 0, 5, 12.5, 25, 50 or 100 µM
Incubation Time: 24 h, 48 h or 72 h
Result: Concentration-dependently inhibited cell growth.
Molecular Weight

934.18

Formula

C46H63N9O8S2

CAS No.
SMILES

O=C([C@@H](NC1=O)CCSC)NCCCCCOC2=CC=C(C=C2)C[C@@H]1NC([C@H](CCCCNC(C)=S)NC([C@@H]3CC4=CC=C(OCCCC(N[C@H](C(N3)=O)CC5=CN=CN5)=O)C=C4)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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SIRT1/2/3-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
SIRT1/2/3-IN-1
Cat. No.:
HY-150568
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