1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Solriamfetol hydrochloride

Solriamfetol hydrochloride (Synonyms: JZP-110 hydrochloride; ADX-N05 hydrochloride; R228060 hydrochloride)

Cat. No.: HY-109043A Purity: 99.50%
Handling Instructions

Solriamfetol hydrochloride (JZP-110 hydrochloride) is an orally active and selective dopamine and norepinephrine reuptake inhibitor with IC50s of 2.9 μM and 4.4 μM for dopamine and norepinephrine transporters, respectively. Solriamfetol hydrochloride has robust wake-promoting effects.

For research use only. We do not sell to patients.

Solriamfetol hydrochloride Chemical Structure

Solriamfetol hydrochloride Chemical Structure

CAS No. : 178429-65-7

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10 mM * 1  mL in DMSO USD 325 In-stock
Estimated Time of Arrival: December 31
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100 mg USD 495 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Solriamfetol hydrochloride (JZP-110 hydrochloride) is an orally active and selective dopamine and norepinephrine reuptake inhibitor with IC50s of 2.9 μM and 4.4 μM for dopamine and norepinephrine transporters, respectively. Solriamfetol hydrochloride has robust wake-promoting effects[1][2].

IC50 & Target

IC50: 2.9 μM (dopamine transporter) and 4.4 μM (norepinephrine transporter)[1]

In Vitro

Solriamfetol hydrochloride (JZP-110 hydrochloride) has the binding affinity for dopamine transporter (DAT; Ki=14,200 nM) and norepinephrine transporter (NET; Ki=3700 nM)[1].

In Vivo

Solriamfetol hydrochloride (JZP-110 hydrochloride; s.c.; 10, 30 mg/kg; eight consecutive 50-minute) increases DA and NE levels in the striatum and prefrontal cortex, respectively[1].
Solriamfetol hydrochloride (i.p.; 3, 10, 30, 100 mg/kg) dose dependently decreases the rate of responding. Solriamfetol of 100 mg/kg results in a significant decrease in response rate to approximately 40% of control[1].
solriamfetol hydrochloride (po; 35 mg/kg) produces a plasma Cmax of 23.1 μM[1].

Animal Model: Male Sprague-Dawley rats weighing 200-400 g[1]
Dosage: 10 and 30 mg/kg
Administration: S.c.; eight consecutive 50-minute
Result: Increased DA and NE levels in the striatum and prefrontal cortex, respectively.
Clinical Trial
Molecular Weight

230.69

Formula

C₁₀H₁₅ClN₂O₂

CAS No.

178429-65-7

SMILES

N[[email protected]@H](COC(N)=O)CC1=CC=CC=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1083.71 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3348 mL 21.6741 mL 43.3482 mL
5 mM 0.8670 mL 4.3348 mL 8.6696 mL
10 mM 0.4335 mL 2.1674 mL 4.3348 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (9.02 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (9.02 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (9.02 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SolriamfetolJZP-110ADX-N05R228060JZP110JZP 110R 228060R-228060Dopamine Receptordopaminenorepinephrinereuptaketransportersrobustwake-promotingeffectsInhibitorinhibitorinhibit

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Product Name:
Solriamfetol hydrochloride
Cat. No.:
HY-109043A
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