1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Solriamfetol hydrochloride

Solriamfetol hydrochloride (Synonyms: JZP-110 hydrochloride; ADX-N05 hydrochloride; R228060 hydrochloride)

Cat. No.: HY-109043A
Handling Instructions

Solriamfetol hydrochloride (JZP-110 hydrochloride) is an orally active and selective dopamine and norepinephrine reuptake inhibitor with IC50s of 2.9 μM and 4.4 μM for dopamine and norepinephrine transporters, respectively. Solriamfetol hydrochloride has robust wake-promoting effects.

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Solriamfetol hydrochloride Chemical Structure

Solriamfetol hydrochloride Chemical Structure

CAS No. : 178429-65-7

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Description

Solriamfetol hydrochloride (JZP-110 hydrochloride) is an orally active and selective dopamine and norepinephrine reuptake inhibitor with IC50s of 2.9 μM and 4.4 μM for dopamine and norepinephrine transporters, respectively. Solriamfetol hydrochloride has robust wake-promoting effects[1][2].

IC50 & Target

IC50: 2.9 μM (dopamine transporter) and 4.4 μM (norepinephrine transporter)[1]

In Vitro

Solriamfetol hydrochloride (JZP-110 hydrochloride) has the binding affinity for dopamine transporter (DAT; Ki=14,200 nM) and norepinephrine transporter (NET; Ki=3700 nM)[1].

In Vivo

Solriamfetol hydrochloride (JZP-110 hydrochloride; s.c.; 10, 30 mg/kg; eight consecutive 50-minute) increases DA and NE levels in the striatum and prefrontal cortex, respectively[1].
Solriamfetol hydrochloride (i.p.; 3, 10, 30, 100 mg/kg) dose dependently decreases the rate of responding. Solriamfetol of 100 mg/kg results in a significant decrease in response rate to approximately 40% of control[1].
solriamfetol hydrochloride (po; 35 mg/kg) produces a plasma Cmax of 23.1 μM[1].

Animal Model: Male Sprague-Dawley rats weighing 200-400 g[1]
Dosage: 10 and 30 mg/kg
Administration: S.c.; eight consecutive 50-minute
Result: Increased DA and NE levels in the striatum and prefrontal cortex, respectively.
Molecular Weight

230.69

Formula

C₁₀H₁₅ClN₂O₂

CAS No.

178429-65-7

SMILES

N[[email protected]@H](COC(N)=O)CC1=CC=CC=C1.[H]Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SolriamfetolJZP-110ADX-N05R228060JZP110JZP 110R 228060R-228060Dopamine Receptordopaminenorepinephrinereuptaketransportersrobustwake-promotingeffectsInhibitorinhibitorinhibit

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Solriamfetol hydrochloride
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HY-109043A
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