1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Solriamfetol

Solriamfetol (Synonyms: JZP-110; ADX-N05; R228060)

Cat. No.: HY-109043 Purity: 98.01%
Handling Instructions

Solriamfetol (JZP-110) is an orally active and selective dopamine and norepinephrine reuptake inhibitor with IC50s of 2.9 μM and 4.4 μM for dopamine and norepinephrine transporters, respectively. Solriamfetol has robust wake-promoting effects.

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Solriamfetol Chemical Structure

Solriamfetol Chemical Structure

CAS No. : 178429-62-4

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10mM/1ml USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 230 In-stock
Estimated Time of Arrival: December 31
100 mg USD 375 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Solriamfetol (JZP-110) is an orally active and selective dopamine and norepinephrine reuptake inhibitor with IC50s of 2.9 μM and 4.4 μM for dopamine and norepinephrine transporters, respectively. Solriamfetol has robust wake-promoting effects[1][2].

IC50 & Target

IC50: 2.9 μM (dopamine transporter) and 4.4 μM (norepinephrine transporter)[1]

In Vitro

Solriamfetol (JZP-110) binds to dopamine and norepinephrine transporters. Solriamfetol has the binding affinity for dopamine transporter (DAT; Ki=14,200 nM) and norepinephrine transporter (NET; Ki=3700 nM)[1].

In Vivo

Solriamfetol (JZP-110; s.c.; 10, 30 mg/kg; eight consecutive 50-minute) increases DA and NE levels in the striatum and prefrontal cortex, respectively[1].
Solriamfetol (i.p.; 3, 10, 30, 100 mg/kg) dose dependently decreases the rate of responding. Solriamfetol of 100 mg/kg results in a significant decrease in response rate to approximately 40% of control[1].
solriamfetol (po; 35 mg/kg) produces a plasma Cmax of 23.1 μM[1].

Animal Model: Male Sprague-Dawley rats weighing 200-400 g[1]
Dosage: 10 and 30 mg/kg
Administration: S.c.; eight consecutive 50-minute
Result: Increased DA and NE levels in the striatum and prefrontal cortex, respectively.
Clinical Trial
Molecular Weight

194.23

Formula

C₁₀H₁₄N₂O₂

CAS No.

178429-62-4

SMILES

N[[email protected]@H](COC(N)=O)CC1=CC=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1287.13 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.1485 mL 25.7427 mL 51.4854 mL
5 mM 1.0297 mL 5.1485 mL 10.2971 mL
10 mM 0.5149 mL 2.5743 mL 5.1485 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.25 mg/mL (11.58 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.25 mg/mL (11.58 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.25 mg/mL (11.58 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SolriamfetolJZP-110ADX-N05R228060JZP110JZP 110R 228060R-228060Dopamine Receptordopaminenorepinephrinereuptaketransportersrobustwake-promotingeffectsInhibitorinhibitorinhibit

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Solriamfetol
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HY-109043
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