1. GPCR/G Protein Neuronal Signaling
  2. Somatostatin Receptor
  3. Somatostatin-28 (sheep, human rat mouse)

Somatostatin-28 (sheep, human rat mouse) is a biologically active polypeptide, synthesised in the proximal intestinal epithelial cells. Somatostatin-28 (sheep, human rat mouse) suppresses glucose-stimulated insulin secretion without affecting circulating basal insulin concentration. Somatostatin-28 (sheep, human rat mouse) also targets to somatostatin receptor subtype 5 (SSTR5) to regulate GLP-1 secretion.

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Somatostatin-28 (sheep, human rat mouse) Chemical Structure

Somatostatin-28 (sheep, human rat mouse) Chemical Structure

CAS No. : 73032-94-7

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Description

Somatostatin-28 (sheep, human rat mouse) is a biologically active polypeptide, synthesised in the proximal intestinal epithelial cells. Somatostatin-28 (sheep, human rat mouse) suppresses glucose-stimulated insulin secretion without affecting circulating basal insulin concentration. Somatostatin-28 (sheep, human rat mouse) also targets to somatostatin receptor subtype 5 (SSTR5) to regulate GLP-1 secretion[1][2].

IC50 & Target[2]

SSTR5

 

In Vitro

Somatostatin-28 dose-dependently inhibits GLP-1 secretion stimulated by gastrin-releasing peptide with an EC50 value of 0.01 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Somatostatin-28 (sheep) (1.1 pmol/kg/min; i.v. via a jugular catheter; 15 min) inhibits insulin secretion induced by 25 μg/kg/min glucose in sheep[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Finn-Dorset Horn cross bred sheep (2-5 years old, 70-75 kg)[2]
Dosage: 1.1 pmol/kg/min for 15 min, with or without 25 μg/kg/min glucose;
Administration: Intravenous injection via a jugular catheter;
Result: Significantly inhibited insulin secretion, resulted serum concentrations decreasing from about 200 to 150 pmol/L.
Molecular Weight

3148.56

Formula

C137H207N41O39S3

CAS No.
Sequence

Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys (Disulfide bridge:Cys17-Cys28)

Sequence Shortening

SANSNPAMAPRERKAGCKNFFWKTFTSC (Disulfide bridge: Cys17-Cys28)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Somatostatin-28 (sheep, human rat mouse) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Somatostatin-28 (sheep, human rat mouse)
Cat. No.:
HY-P3954
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