1. NF-κB
    Apoptosis
  2. NF-κB
    Apoptosis
  3. SP-8356

SP-8356 

Cat. No.: HY-130234
Handling Instructions

SP-8356, an anti-inflammatory synthetic verbenone derivative, is a potent, orally active cluster of differentiation 147 (CD147) inhibitor. SP-8356 inhibits CD147-cyclophilin A (CypA) interaction and reduces MMP-9 activity. SP-8356 exerts anti-breast cancer effects by inhibiting NF-κB signaling. Anti-atherosclerotic effects.

For research use only. We do not sell to patients.

SP-8356 Chemical Structure

SP-8356 Chemical Structure

CAS No. : 1454885-45-0

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Description

SP-8356, an anti-inflammatory synthetic verbenone derivative, is a potent, orally active cluster of differentiation 147 (CD147) inhibitor. SP-8356 inhibits CD147-cyclophilin A (CypA) interaction and reduces MMP-9 activity. SP-8356 exerts anti-breast cancer effects by inhibiting NF-κB signaling. Anti-atherosclerotic effects[1][2][3].

In Vitro

SP-8356 (5-10 μM; 48 hours) inhibits growth of various types of breast cancer cell lines in a time- and dose-dependent manner[1].
SP-8356 (10 μM; 48 hours) increases percentage of MDA-MB231 cells in S phase and decreases casapas-3 and cleaved PARP[1].

Cell Proliferation Assay[1]

Cell Line: MDA-MB231, MDA-MB453, 4T1, and MCF-7 cells
Concentration: 5, 10 μM
Incubation Time: 48 hours
Result: Inhibited growth of various types of breast cancer cell lines in a time- and dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: MDA-MB231 cells
Concentration: 1, 5, 10 μM
Incubation Time: 48 hours
Result: Increased percentage of MDA-MB231 cells in S phase at 10 μM.

Western Blot Analysis[1]

Cell Line: MDA-MB231 cells
Concentration: 10 μM
Incubation Time: 48 hours
Result: Decrease of casapas-3 and cleaved PARP were observed.
In Vivo

SP-8356 (10 mg/kg; i.p.; every three days until the 42nd day) inhibits tumor growth in a xenograft mouse model[1].
SP-8356 (50 mg/kg; p.o.; daily one day after carotid artery ligation for three weeks) prevents the formation of plaque and attenuates its vulnerability[2].

Animal Model: Five-week-old female NOD/SCID mice (MDA-MB231 xenografts)[1]
Dosage: 10 mg/kg
Administration: I.p.; every three days until the 42nd day
Result: The tumor volumes of mice were significantly lower.
Animal Model: Male ApoE KO mice (7 weeks old, 20 g body weight)[2]
Dosage: 50 mg/kg
Administration: P.o.; daily one day after carotid artery ligation for three weeks
Result: Induced a significant reduction in plaque size and plaque/media ratiowith decreased lipid and necrotic core areas.
Molecular Weight

300.35

Formula

C₁₈H₂₀O₄

CAS No.

1454885-45-0

SMILES

O=C1[[email protected]](C2)([H])C(C)(C)[[email protected]]2([H])C(/C=C/C3=CC(OC)=C(O)C(O)=C3)=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SP-8356SP8356SP 8356NF-κBApoptosisNuclear factor-κBNuclear factor-kappaBtriple-negativebreastcancercellsTNBCmetastasisplaqueprogressionatheroscleroticMMP-9Inhibitorinhibitorinhibit

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