Successful, we will reply to you quickly.

OK

Please select the quantity.

OK

Your message is being sent, please wait.

Close

test

Close

Send mail failed, please send again!

Close

Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

Staurosporine

HY-15141

(Antibiotic AM-2282; STS; AM-2282)

Staurosporine

Staurosporine Chemical Structure

Staurosporine is a prototypical potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $113 In-stock
2 mg $80 In-stock
5 mg $110 In-stock
10 mg $150 In-stock
50 mg Get quote
100 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €111 In-stock
2 mg €78 In-stock
5 mg €108 In-stock
10 mg €147 In-stock
50 mg Get quote
100 mg Get quote

* Please select Quantity before adding items.

Bulk Inquiry

Inquiry Information
Product name: Staurosporine
Cat. No.: HY-15141

Staurosporine Data Sheet

  • View current batch:

    Purity: 98.80%

  • Network Version

    DataSheet

    Pdf Version Network Version

    MSDS

    Pdf Version

    COA

Customer View

Related Compound Libraries

Biological Activity of Staurosporine

Staurosporine is a prototypical potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively.
IC50 value:
Target: PKC
The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. This lack of specificity has precluded its clinical use, but has made it a valuable research tool. In research, staurosporine is used to induce apoptosis. The mechanism of how it mediates this is not well understood. It has been found that one way in which staurosporine induces apoptosis is by activating caspase-3.
 

Chemical Information

M.Wt 466.53 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₂₈H₂₆N₄O₃
CAS No 62996-74-1
Solvent & Solubility

DMSO: ≥ 31 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.1435 mL 10.7174 mL 21.4348 mL
5 mM 0.4287 mL 2.1435 mL 4.2870 mL
10 mM 0.2143 mL 1.0717 mL 2.1435 mL

References on Staurosporine

Inhibitor Kit

Related PKA , PKC Products

  • (-)-Indolactam V

    (-)-Indolactam V (ILV) is a protein kinase C activator, which strongly directs human ES cell-derived definitive endoderm into pancreatic endoderm.

  • AZD5363

    AZD5363, a novel pyrrolopyrimidine-derived compound, inhibits all AKT isoforms (IC50 <10 nM).

  • Bisindolylmaleimide I

    Bisindolylmaleimide I (GF109203X) is a highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor with a Ki value of 14 nM.

  • CCG215022

    CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15(plusmn)0.07 (mu)M, 0.38(plusmn)0.06 (mu)M and 3.9(plusmn)1 (mu)M for GRK2, 5 and 1, respectively.

  • CGP60474

    CGP60474 is a promising inhibitor of PKC with a high degree of selectivity versus other serine/threonine and tyrosine kinases and show competitive kinetics relative to ATP.

  • Chelerythrine Chloride

    Chelerythrine is potent, cell-permeable inhibitor of protein kinase C (IC50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.

  • Enzastaurin

    Enzastaurin (LY317615) is a potent PKC(beta) selective inhibitor with IC50 of 6 nM, 6- to 20-fold selectivity against PKC(alpha), PKC(gamma) and PKC(epsilon).

  • Go 6983

    Go 6983 is a pan-PKC inhibitor against for PKC(alpha), PKC(beta), PKC(gamma) and PKC(delta) with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively; less potent to PKC(zeta) and inactive to PKC(mu).

  • Phorbol 12-myristate 13-acetate

    Phorbol 12-myristate 13-acetate (PMA) is a PKC-activating phorbol ester, increases the intracellular Ca2(addition) concentration ([Ca2(addition)]i) in a dose-dependent manner, with an EC50 of 11.7 nM.

  • PKC-IN-1

    PKC-IN-1 is a poent PKC beta II inhibitor with Ki of 14.9 nM; compound example H6 from patent WO 2008096260 A1.

MORE