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Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

Staurosporine

HY-15141

(Antibiotic AM-2282; STS; AM-2282)

Staurosporine

Staurosporine Chemical Structure

Staurosporine is a prototypical potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $113 In-stock
2 mg $80 In-stock
5 mg $110 In-stock
10 mg $150 In-stock
50 mg Get quote
100 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €111 In-stock
2 mg €78 In-stock
5 mg €108 In-stock
10 mg €147 In-stock
50 mg Get quote
100 mg Get quote

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Product name: Staurosporine
Cat. No.: HY-15141

Staurosporine Data Sheet

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    Purity: 98.80%

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    DataSheet

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Related Compound Libraries

Biological Activity of Staurosporine

Staurosporine is a prototypical potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively.
IC50 value:
Target: PKC
The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. This lack of specificity has precluded its clinical use, but has made it a valuable research tool. In research, staurosporine is used to induce apoptosis. The mechanism of how it mediates this is not well understood. It has been found that one way in which staurosporine induces apoptosis is by activating caspase-3.
 

Chemical Information

M.Wt 466.53 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C28H26N4O3
CAS No 62996-74-1
Solvent & Solubility

DMSO: ≥ 31 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.1435 mL 10.7174 mL 21.4348 mL
5 mM 0.4287 mL 2.1435 mL 4.2870 mL
10 mM 0.2143 mL 1.0717 mL 2.1435 mL

References on Staurosporine

Inhibitor Kit

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