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Steroid sulfatase/17β-HSD1-IN-1 

Cat. No.: HY-151199
Handling Instructions

Steroid sulfatase/17β-HSD1-IN-1 is a potent steroid sulfatase and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitor with an IC50 value of 28 nM for cellular human steroid sulfatase. Steroid sulfatase/17β-HSD1-IN-1 can be used to research estrogen-dependent diseases.

For research use only. We do not sell to patients.

Steroid sulfatase/17β-HSD1-IN-1 Chemical Structure

Steroid sulfatase/17β-HSD1-IN-1 Chemical Structure

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Description

Steroid sulfatase/17β-HSD1-IN-1 is a potent steroid sulfatase and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitor with an IC50 value of 28 nM for cellular human steroid sulfatase. Steroid sulfatase/17β-HSD1-IN-1 can be used to research estrogen-dependent diseases[1].

IC50 & Target

IC50: 28 nM (cellular human steroid sulfatase)[1]

In Vitro

Steroid sulfatase/17β-HSD1-IN-1 (compound 13) (20 μM; 48 h) has a low cytotoxicity in HEK-293 cells[1].
Steroid sulfatase/17β-HSD1-IN-1 (50-750 nM; 0-25 min) can inhibit T47D cells growth and 17β-HSD1 in a time-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: HEK-293 cells
Concentration: 20 μM
Incubation Time: 48 h
Result: Exhibited a low cytotoxicity with the cell growth inhibition of 12.8%.

Cell Proliferation Assay[1]

Cell Line: T47D
Concentration: 50, 100, 250, 500 and 750 nM
Incubation Time: 0-25 min
Result: Inhibited cell growth and 17β-HSD1 in a time-dependent manner.
In Vivo

Steroid sulfatase/17β-HSD1-IN-1 shows good metabolic stability in human hepatic S9 fraction (t1/2=47 min) and low intrinsic clearance Clint (15 μL/min/mg protein)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

386.42

Formula

C19H18N2O5S

SMILES

CC1=CC=CC=C1N(C(C2=CC=C(O2)C3=CC=C(C=C3)OS(N)(=O)=O)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
Steroid sulfatase/17β-HSD1-IN-1
Cat. No.:
HY-151199
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